ARHGDIA

Summary Top Help

Gene Description:

Rho GDP dissociation inhibitor (GDI) alpha

Synonyms:

GDIA1, RhoGDI-1, RhoDGI, RHOGDI-1, 5330430M07Rik, Rho-GDI, ARHGDIA, RHOGDI, Arhgdia, Gdi-1

Orthologs:

Human ARHGDIA (protein-coding), Mouse Arhgdia (protein-coding), Rat Arhgdia (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:79825597..79829282 (3.69 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:120438549..120442938 (4.39 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:109967771..109971260 (3.49 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ARHGDIA:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ARHGDIA:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: None available

Reactome: 7

NCI-Nature Pathway Interaction Database: 8

Gene Ontology: 18

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 125

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.
Yang W, Thompson JW, Wang Z, Wang L, Sheng H, Foster MW, Moseley MA, Paschen W
J Proteome Res. 2012
PubMed ID: 22082260
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
Giang Ho TT, Stultiens A, Dubail J, Lapière CM, Nusgens BV, Colige AC, Deroanne CF
Mol Biol Cell. 2011
PubMed ID: 21757538
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
Shibata S, Mu S, Kawarazaki H, Muraoka K, Ishizawa K, Yoshida S, Kawarazaki W, Takeuchi M, Ayuzawa N, Miyoshi J, Takai Y, Ishikawa A, Shimosawa T, Ando K, Nagase M, Fujita T
J Clin Invest. 2011
PubMed ID: 21765214
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.
Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH
Nat Cell Biol. 2011
PubMed ID: 21572420
X-linked inhibitor of apoptosis protein (XIAP) mediates cancer cell motility via Rho GDP dissociation inhibitor (RhoGDI)-dependent regulation of the cytoskeleton.
Liu J, Zhang D, Luo W, Yu Y, Yu J, Li J, Zhang X, Zhang B, Chen J, Wu XR, Rosas-Acosta G, Huang C
J Biol Chem. 2011
PubMed ID: 21402697
Loss of Rho GDIα and resistance to tamoxifen via effects on estrogen receptor α.
Barone I, Brusco L, Gu G, Selever J, Beyer A, Covington KR, Tsimelzon A, Wang T, Hilsenbeck SG, Chamness GC, Andò S, Fuqua SA
J Natl Cancer Inst. 2011
PubMed ID: 21447808
[Expression of RhoGDI alpha in human testes and sperm and its correlation with the success rate of IVF].
Shi ZH, Zhao C, Wu H, Liu XM
Zhonghua Nan Ke Xue. 2011
PubMed ID: 21548210
Genes associated with prognosis after surgery for malignant pleural mesothelioma promote tumor cell survival in vitro.
Gordon GJ, Bueno R, Sugarbaker DJ
BMC Cancer. 2011
PubMed ID: 21569526
Targeting S100P inhibits colon cancer growth and metastasis by Lentivirus-mediated RNA interference and proteomic analysis.
Jiang L, Lai YK, Zhang J, Wang H, Lin MC, He ML, Kung HF
Mol Med. 2011
PubMed ID: 21327297
[Expression of Rho-GDP dissociation inhibitor in the decidual tissues of preeclampsia patients and its clinical implication].
Feng YL, Liang XQ, Zhou CJ
Nan Fang Yi Ke Da Xue Xue Bao. 2011
PubMed ID: 21269984
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Endocytosis and toxicity of clostridial binary toxins depend on a clathrin-independent pathway regulated by Rho-GDI.
Gibert M, Monier MN, Ruez R, Hale ML, Stiles BG, Benmerah A, Johannes L, Lamaze C, Popoff MR
Cell Microbiol. 2011
PubMed ID: 20846184
Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.
Li X, Lee AY
J Biol Chem. 2010
PubMed ID: 20696765
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma.
Zhao L, Wang H, Sun X, Ding Y
FEBS J. 2010
PubMed ID: 20812987
RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migration.
Rolli-Derkinderen M, Toumaniantz G, Pacaud P, Loirand G
Mol Cell Biol. 2010
PubMed ID: 20696841
The role of ezrin-associated protein network in human sperm capacitation.
Wang L, Chen W, Zhao C, Huo R, Guo XJ, Lin M, Huang XY, Mao YD, Zhou ZM, Sha JH
Asian J Androl. 2010
PubMed ID: 20711218
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion.
Dovas A, Choi Y, Yoneda A, Multhaupt HA, Kwon SH, Kang D, Oh ES, Couchman JR
J Biol Chem. 2010
PubMed ID: 20472934
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.
Boulter E, Garcia-Mata R, Guilluy C, Dubash A, Rossi G, Brennwald PJ, Burridge K
Nat Cell Biol. 2010
PubMed ID: 20400958
Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.
Martins-de-Souza D, Schmitt A, Röder R, Lebar M, Schneider-Axmann T, Falkai P, Turck CW
J Psychiatr Res. 2010
PubMed ID: 20381070
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, Wang H, Gu J, Yao M, Li J, Tu H, He X
Nat Cell Biol. 2010
PubMed ID: 20305651
Cyclic strain modulates migration and proliferation of vascular smooth muscle cells via Rho-GDIalpha, Rac1, and p38 pathway.
Qi YX, Qu MJ, Yan ZQ, Zhao D, Jiang XH, Shen BR, Jiang ZL
J Cell Biochem. 2010
PubMed ID: 20069557
Rho GDP dissociation inhibitor alpha expression correlates with the outcome of CMF treatment in invasive ductal breast cancer.
Ronneburg H, Span PN, Kantelhardt E, Dittmer A, Schunke D, Holzhausen HJ, Sweep FC, Dittmer J
Int J Oncol. 2010
PubMed ID: 20043072
Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Bielek H, Anselmo A, Dermardirossian C
Cell Signal. 2009
PubMed ID: 19765647
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway.
Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M
J Cell Biol. 2009
PubMed ID: 19581409
Expression of Rho GDIalpha in rat osteoblasts intermittently exposed to parathyroid hormone in vitro and in vivo.
Sun ZF, Jiang H, Ye ZQ, Jia B, Zhang XL, Zhang KQ
Acta Pharmacol Sin. 2009
PubMed ID: 19575003
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma.
Gordon GJ, Dong L, Yeap BY, Richards WG, Glickman JN, Edenfield H, Mani M, Colquitt R, Maulik G, Van Oss B, Sugarbaker DJ, Bueno R
J Natl Cancer Inst. 2009
PubMed ID: 19401544
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Proteome profile of the mature rat olfactory bulb.
Maurya DK, Sundaram CS, Bhargava P
Proteomics. 2009
PubMed ID: 19343716
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI.
Abramovici H, Mojtabaie P, Parks RJ, Zhong XP, Koretzky GA, Topham MK, Gee SH
Mol Biol Cell. 2009
PubMed ID: 19211846
Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells.
Shin EY, Shim ES, Lee CS, Kim HK, Kim EG
Biochem Biophys Res Commun. 2009
PubMed ID: 19103160
Impairment of cerebello-thalamo-frontal pathway in Rab-GDI mutated patients with pure mental deficiency.
Curie A, Sacco S, Bussy G, de Saint Martin A, Boddaert N, Chanraud S, Meresse I, Chelly J, Zilbovicius M, des Portes V
Eur J Med Genet. 2009
PubMed ID: 18992375
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Shibata S, Nagase M, Yoshida S, Kawarazaki W, Kurihara H, Tanaka H, Miyoshi J, Takai Y, Fujita T
Nat Med. 2008
PubMed ID: 19029984
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK
Nat Med. 2008
PubMed ID: 19029981
Phosphorylation of GTP dissociation inhibitor by PKA negatively regulates RhoA.
Qiao J, Holian O, Lee BS, Huang F, Zhang J, Lum H
Am J Physiol Cell Physiol. 2008
PubMed ID: 18768928
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Rho-GDP dissociation inhibitor alpha downregulated by low shear stress promotes vascular smooth muscle cell migration and apoptosis: a proteomic analysis.
Qi YX, Qu MJ, Long DK, Liu B, Yao QP, Chien S, Jiang ZL
Cardiovasc Res. 2008
PubMed ID: 18540023
Interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.
Ho C, Shanmugasundararaj S, Miller KW, Malinowski SA, Cook AC, Slater SJ
Biochemistry. 2008
PubMed ID: 18702520
Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer.
Zhao L, Wang H, Li J, Liu Y, Ding Y
J Proteome Res. 2008
PubMed ID: 18651761
Role of Rac and Rho-GDI alpha in the frequency-dependent expression of h1-calponin in vascular smooth muscle cells under cyclic mechanical strain.
Qu MJ, Liu B, Qi YX, Jiang ZL
Ann Biomed Eng. 2008
PubMed ID: 18566890
Dissociation of Rac1(GDP).RhoGDI complexes by the cooperative action of anionic liposomes containing phosphatidylinositol 3,4,5-trisphosphate, Rac guanine nucleotide exchange factor, and GTP.
Ugolev Y, Berdichevsky Y, Weinbaum C, Pick E
J Biol Chem. 2008
PubMed ID: 18505730
RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha.
Ho TT, Merajver SD, Lapière CM, Nusgens BV, Deroanne CF
J Biol Chem. 2008
PubMed ID: 18524772
Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles.
Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M
Biochim Biophys Acta. 2008
PubMed ID: 18442487
Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin.
Larsen AK, Lametsch R, Elce J, Larsen JK, Thomsen B, Larsen MR, Lawson MA, Greer PA, Ertbjerg P
Biochem J. 2008
PubMed ID: 18076376
Rho GDP dissociation inhibitor-mediated disruption of Rho GTPase activity impairs lens fiber cell migration, elongation and survival.
Maddala R, Reneker LW, Pendurthi B, Rao PV
Dev Biol. 2008
PubMed ID: 18234179
Activity of the Bcr GTPase-activating domain is regulated through direct protein/protein interaction with the Rho guanine nucleotide dissociation inhibitor.
Kweon SM, Cho YJ, Minoo P, Groffen J, Heisterkamp N
J Biol Chem. 2008
PubMed ID: 18070886
A proteomic analysis of aorta from spontaneously hypertensive rat: RhoGDI alpha upregulation by angiotensin II via AT(1) receptor.
Bian YL, Qi YX, Yan ZQ, Long DK, Shen BR, Jiang ZL
Eur J Cell Biol. 2008
PubMed ID: 17963997
Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression.
Park CK, Kim JH, Moon MJ, Jung JH, Lim SY, Park SH, Kim JH, Kim DG, Jung HW, Cho BK, Paek SH
J Cancer Res Clin Oncol. 2008
PubMed ID: 17653765
Rho GDP dissociation inhibitor alpha interacts with estrogen receptor alpha and influences estrogen responsiveness.
El Marzouk S, Schultz-Norton JR, Likhite VS, McLeod IX, Yates JR, Nardulli AM
J Mol Endocrinol. 2007
PubMed ID: 17909265
RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs.
Gorovoy M, Neamu R, Niu J, Vogel S, Predescu D, Miyoshi J, Takai Y, Kini V, Mehta D, Malik AB, Voyno-Yasenetskaya T
Circ Res. 2007
PubMed ID: 17525371
Proteomics study reveals cross-talk between Rho guanidine nucleotide dissociation inhibitor 1 post-translational modifications in epidermal growth factor stimulated fibroblasts.
Guerrera IC, Keep NH, Godovac-Zimmermann J
J Proteome Res. 2007
PubMed ID: 17506542
Roles of glial p75NTR in axonal regeneration.
Zhou XF, Li HY
J Neurosci Res. 2007
PubMed ID: 17335080
Differential protein expression profile in the intestinal epithelium from patients with inflammatory bowel disease.
Shkoda A, Werner T, Daniel H, Gunckel M, Rogler G, Haller D
J Proteome Res. 2007
PubMed ID: 17330946
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta.
Ishizaki H, Togawa A, Tanaka-Okamoto M, Hori K, Nishimura M, Hamaguchi A, Imai T, Takai Y, Miyoshi J
J Immunol. 2006
PubMed ID: 17142749
A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes.
Su L, Lineberry N, Huh Y, Soares L, Fathman CG
J Immunol. 2006
PubMed ID: 17114425
Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling.
DerMardirossian C, Rocklin G, Seo JY, Bokoch GM
Mol Biol Cell. 2006
PubMed ID: 16943322
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Mol Cell. 2006
PubMed ID: 16916647
Rac3-induced neuritogenesis requires binding to Neurabin I.
Orioli D, Colaluca IN, Stefanini M, Riva S, Dotti CG, Peverali FA
Mol Biol Cell. 2006
PubMed ID: 16525025
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression.
Coiras M, Camafeita E, Ureña T, López JA, Caballero F, Fernández B, López-Huertas MR, Pérez-Olmeda M, Alcamí J
Proteomics. 2006
PubMed ID: 16526095
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY
Biochem Biophys Res Commun. 2005
PubMed ID: 16236267
Multiple signals regulate axon regeneration through the Nogo receptor complex.
Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F
Mol Neurobiol. 2005
PubMed ID: 16215275
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B
Proteomics. 2005
PubMed ID: 16130169
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIgamma.
Ferland RJ, Li X, Buhlmann JE, Bu X, Walsh CA, Lim B
Brain Res. 2005
PubMed ID: 16054116
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.
Papaharalambus C, Sajjad W, Syed A, Zhang C, Bergo MO, Alexander RW, Ahmad M
J Biol Chem. 2005
PubMed ID: 15647276
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
Gajate C, Mollinedo F
J Biol Chem. 2005
PubMed ID: 15659383
Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors.
Dransart E, Morin A, Cherfils J, Olofsson B
J Biol Chem. 2005
PubMed ID: 15513926
RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes.
Yatani A, Irie K, Otani T, Abdellatif M, Wei L
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15471984
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase.
DerMardirossian C, Schnelzer A, Bokoch GM
Mol Cell. 2004
PubMed ID: 15225553
p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity.
Gehler S, Gallo G, Veien E, Letourneau PC
J Neurosci. 2004
PubMed ID: 15128850
Rho localization in cells and tissues.
Yonemura S, Hirao-Minakuchi K, Nishimura Y
Exp Cell Res. 2004
PubMed ID: 15093731
Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.
Wei L, Taffet GE, Khoury DS, Bo J, Li Y, Yatani A, Delaughter MC, Klevitsky R, Hewett TE, Robbins J, Michael LH, Schneider MD, Entman ML, Schwartz RJ
FASEB J. 2004
PubMed ID: 15033930
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.
Filbin MT
Nat Rev Neurosci. 2003
PubMed ID: 12951563
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.
Yamashita T, Tohyama M
Nat Neurosci. 2003
PubMed ID: 12692556
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ
Development. 2002
PubMed ID: 11923206
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.
Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B
Mol Cell Biol. 2002
PubMed ID: 11809807
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.
Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI
Immunity. 2001
PubMed ID: 11728336
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.
Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A
Science. 2001
PubMed ID: 11546872
Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.
Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC
Biochemistry. 2001
PubMed ID: 11513579
Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation.
Grizot S, Fauré J, Fieschi F, Vignais PV, Dagher MC, Pebay-Peyroula E
Biochemistry. 2001
PubMed ID: 11513578
Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI).
Fauré J, Dagher MC
Biochimie. 2001
PubMed ID: 11368848
Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI.
Longenecker KL, Garrard SM, Sheffield PJ, Derewenda ZS
Acta Crystallogr D Biol Crystallogr. 2001
PubMed ID: 11320308
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.
Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR
J Cell Biol. 2001
PubMed ID: 11149925
Database resources of the National Center for Biotechnology Information.
Wheeler DL, Church DM, Lash AE, Leipe DD, Madden TL, Pontius JU, Schuler GD, Schriml LM, Tatusova TA, Wagner L, Rapp BA
Nucleic Acids Res. 2001
PubMed ID: 11125038
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI.
Hoffman GR, Nassar N, Cerione RA
Cell. 2000
PubMed ID: 10676816
Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation.
Groysman M, Russek CS, Katzav S
FEBS Lett. 2000
PubMed ID: 10664460
Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1.
Lian LY, Barsukov I, Golovanov AP, Hawkins DI, Badii R, Sze KH, Keep NH, Bokoch GM, Roberts GC
Structure. 2000
PubMed ID: 10673424
The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.
Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W
Cell Death Differ. 2000
PubMed ID: 10713718
Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth.
Yamashita T, Tucker KL, Barde YA
Neuron. 1999
PubMed ID: 10595511
Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha.
Togawa A, Miyoshi J, Ishizaki H, Tanaka M, Takakura A, Nishioka H, Yoshida H, Doi T, Mizoguchi A, Matsuura N, Niho Y, Nishimune Y, Nishikawa S, Takai Y
Oncogene. 1999
PubMed ID: 10498891
How RhoGDI binds Rho.
Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, Walker L, Somlyo AV, Nakamoto RK, Somlyo AP, Derewenda ZS
Acta Crystallogr D Biol Crystallogr. 1999
PubMed ID: 10489445
The interaction between rac1 and its guanine nucleotide dissociation inhibitor (GDI), monitored by a single fluorescent coumarin attached to GDI.
Newcombe AR, Stockley RW, Hunter JL, Webb MR
Biochemistry. 1999
PubMed ID: 10346909
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl.
Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y
Oncogene. 1998
PubMed ID: 9681826
Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.
Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P
FEBS Lett. 1998
PubMed ID: 9490022
Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein.
Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y
J Biol Chem. 1997
PubMed ID: 9287351
A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.
Keep NH, Barnes M, Barsukov I, Badii R, Lian LY, Segal AW, Moody PC, Roberts GC
Structure. 1997
PubMed ID: 9195882
A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3.
Wagner T, Tommerup N, Wirth J, Leffers H, Zimmer J, Back E, Weissenbach J, Scherer G
Cytogenet Cell Genet. 1997
PubMed ID: 9186513
RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.
Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B
J Biol Chem. 1996
PubMed ID: 8939998
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.
Leffers H, Nielsen MS, Andersen AH, Honoré B, Madsen P, Vandekerckhove J, Celis JE
Exp Cell Res. 1993
PubMed ID: 8262133
Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.
Kwong CH, Malech HL, Rotrosen D, Leto TL
Biochemistry. 1993
PubMed ID: 8504089

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	396	192662	360678
EnsEMBL Gene(s)	ENSG00000141522	ENSMUSG00000025132	ENSRNOG00000036688
Unigene	Hs.159161	Mm.30016	Rn.1801
Homologene	ARHGDIA	Arhgdia	Arhgdia
OMIM	601925	N/A	N/A
GeneCards	ARHGDIA	N/A	N/A
Beta Cell Genomics	DT.100039713 DT.100767630 DT.91684644 DT.92471322 DT.97856170 DT.97856243	DT.101224648 DT.110517951 DT.537094 DT.55201905 DT.94300412 DT.97360942	N/A
Reactome	P52565	N/A	N/A
Plasma Peptide Atlas	ENSP00000269321	N/A	N/A
WikiGenes	396	192662	360678

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
ARHGDIA	TRIM13	BioGRID	empirical	21900206
ARHGDIA	CDKN1B	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	IGF2BP1	IntAct	empirical	17353931
ARHGDIA	TWF2	BioGRID	empirical	21900206
ARHGDIA	DHX9	IntAct, BioGRID	empirical	17353931
ARHGDIA	EIF2B1	IntAct, BioGRID	empirical	17353931
ARHGDIA	EWSR1	IntAct, BioGRID	empirical	17353931
ARHGDIA	HNRNPA3	IntAct, BioGRID	empirical	17353931
ARHGDIA	FEN1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	NEDD4L	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	CBX5	BioGRID	empirical	21900206
ARHGDIA	HAAO	BioGRID	empirical	21900206
ARHGDIA	FUS	IntAct	empirical	17353931
ARHGDIA	HNRNPAB	IntAct, BioGRID	empirical	17353931
ARHGDIA	XIAP	BioGRID	empirical	21402697
ARHGDIA	FAS	BioGRID	empirical	15659383
ARHGDIA	FASLG	BioGRID	empirical	15659383
ARHGDIA	JUP	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	RHOA	HPRD, IntAct, BioGRID	empirical	10489445 17353931 15659383 11149925 9490022 11368848
ARHGDIA	SUMO4	HPRD	empirical	16236267
ARHGDIA	RHOB	IntAct	empirical	19637314
ARHGDIA	RHOC	IntAct, BioGRID	empirical	17353931
ARHGDIA	RHOG	BioGRID	empirical	11368848
ARHGDIA	ARHGDIA	HPRD, IntAct, BioGRID	empirical	11320308 9195882 17353931 11513578
ARHGDIA	RHOH	BioGRID	empirical	11809807 11368848
ARHGDIA	MAG	Reactome	predicted
ARHGDIA	MSN	BioGRID	empirical	15659383
ARHGDIA	NGFR	IntAct, Reactome	empirical	21541365 15128850 12692556 9195882
ARHGDIA	OMG	Reactome	predicted
ARHGDIA	ATP5B	IntAct	empirical	15627969
ARHGDIA	UFM1	BioGRID	empirical	21900206
ARHGDIA	UBE2R2	BioGRID	empirical	21900206
ARHGDIA	MAPK6	BioGRID	empirical	21900206
ARHGDIA	MAPK8	BioGRID	empirical	15659383
ARHGDIA	RTN4	Reactome	predicted
ARHGDIA	BAK1	BioGRID	empirical	21900206
ARHGDIA	RAC1	HPRD, MINT, IntAct, BioGRID	empirical	11513579 10673424 10346909 17245428 11513578 17353931 9490022 11368848 21900206
ARHGDIA	RAC2	HPRD, BioGRID	empirical	11513578 9490022 11368848
ARHGDIA	RAC3	MINT, IntAct, BioGRID	empirical	15102471 21900206
ARHGDIA	RDX	HPRD, MINT, BioGRID	empirical	9287351 9681826
ARHGDIA	BID	BioGRID	empirical	15659383
ARHGDIA	SDHC	BioGRID	empirical	21900206
ARHGDIA	SET	MINT	empirical	17245428
ARHGDIA	SH3GL3	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	ST3GAL4	HPRD, MINT, IntAct	empirical	16169070
ARHGDIA	SLC2A4	IntAct	empirical	16396496
ARHGDIA	SUMO3	BioGRID	empirical	22082260
ARHGDIA	TNFRSF1A	BioGRID	empirical	15659383
ARHGDIA	UBC	BioGRID	empirical	20639865 21402697 21906983
ARHGDIA	VAV1	HPRD, MIPS	empirical	10664460
ARHGDIA	EZR	BioGRID	empirical	15659383
ARHGDIA	RNF128	BioGRID	empirical	17114425
ARHGDIA	CASP8	BioGRID	empirical	15659383
ARHGDIA	CASP10	BioGRID	empirical	15659383
ARHGDIA	ACTL6A	HPRD, MINT, IntAct, BioGRID	empirical	16169070
ARHGDIA	FADD	BioGRID	empirical	15659383
ARHGDIA	TNFRSF10B	BioGRID	empirical	15659383
ARHGDIA	UBE2L6	BioGRID	empirical	21900206
ARHGDIA	HERPUD1	BioGRID	empirical	21900206
ARHGDIA	CDC42	HPRD, IntAct, BioGRID	empirical	10676816 11149925 17353931 20936779 9490022 21900206