LAMC2

Summary from T1DBase Top Help

Gene Description:

laminin, gamma 2

Synonyms:

BM600, Lamc2, LAMC2, EBR2, MGC141938, MGC138491, LAMB2T, LAMNB2, AA589349, EBR2A, B2T, CSF

Orthologs:

Human LAMC2 (protein-coding), Mouse Lamc2 (protein-coding), Rat Lamc2 (protein-coding)

Sources

Regions of Interest Overlapping this feature from T1DBase Top Help

Regions Overlapping this Feature: Mouse: 2

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.4	Mouse	chr1:77143053..147306684	70.16	608
Idd5.4b	Mouse	chr1:152631809..157938163	5.31	58

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr1:183155174..183214262 (599 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:154969886..155033577 (63.69 kb) View in Genome Browser

(Rat) RGSC3.4 - chr13:68151074..68211117 (604 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
										no data		no data

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker	EB	MK	CD66b	CD14	CD19	CD8	CD4	CD56
Expression Pattern									HaemAtlasProfile

Expression Legend

Interactions from T1DBase Top Help

Interactions Table for LAMC2:

The LAMC2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
LAMC2	COL7A1	HPRD, BioGRID	empirical	9989793
LAMC2	FBLN2	HPRD	empirical	11733994
LAMC2	PDIA3	MINT	empirical	17170699
LAMC2	LAMA3	IntAct, Reactome	empirical	14681455
LAMC2	LAMA5	IntAct	empirical	14681455
LAMC2	LAMB3	HPRD, Reactome	empirical	10964684
LAMC2	NID1	HPRD	empirical	11733994
LAMC2	BMP1	HPRD	empirical	10806203
LAMC2	SLA2	BioGRID	empirical	17353186

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 6

Biocarta: None available

Reactome: 2

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 13

Publications Top Help

Type 1 Diabetes Publications: 2

Publications: 153

Regional differences in the expression of laminin isoforms during mouse neural tube development.
Copp AJ, Carvalho R, Wallace A, Sorokin L, Sasaki T, Greene ND, Ybot-Gonzalez P
Matrix Biol. 2011
PubMed ID: 21524702
Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer.
Kwon OH, Park JL, Kim M, Kim JH, Lee HC, Kim HJ, Noh SM, Song KS, Yoo HS, Paik SG, Kim SY, Kim YS
Biochem Biophys Res Commun. 2011
PubMed ID: 21345334
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, SLEGEN, Petri M, Demirci FY, Kamboh MI, Manzi S, Gregersen PK, Langefeld CD, Behrens TW, Criswell LA
PLoS Genet. 2011
PubMed ID: 21408207
Type XVII collagen (BP180) can function as a cell-matrix adhesion molecule via binding to laminin 332.
Van den Bergh F, Eliason SL, Giudice GJ
Matrix Biol. 2011
PubMed ID: 21034821
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Mokkapati S, Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, Nischt R
J Biol Chem. 2011
PubMed ID: 21084308
Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing.
Nishiyama T, Kii I, Kashima TG, Kikuchi Y, Ohazama A, Shimazaki M, Fukayama M, Kudo A
PLoS One. 2011
PubMed ID: 21490918
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, Farlow DN, Folsom AR, Fornage M, Forrester T, Fox E, Haiman CA, Hartiala J, Harris TB, Hazen SL, Heckbert SR, Henderson BE, Hirschhorn JN, Keating BJ, Kritchevsky SB, Larkin E, Li M, Rudock ME, McKenzie CA, Meigs JB, Meng YA, Mosley TH, Newman AB, Newton-Cheh CH, Paltoo DN, Papanicolaou GJ, Patterson N, Post WS, Psaty BM, Qasim AN, Qu L, Rader DJ, Redline S, Reilly MP, Reiner AP, Rich SS, Rotter JI, Liu Y, Shrader P, Siscovick DS, Tang WH, Taylor HA, Tracy RP, Vasan RS, Waters KM, Wilks R, Wilson JG, Fabsitz RR, Gabriel SB, Kathiresan S, Boerwinkle E
PLoS Genet. 2011
PubMed ID: 21347282
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Cytoplasmic and stromal expression of laminin γ 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal type.
Okuma E, Ohishi Y, Oda Y, Aishima S, Kurihara S, Nishimura I, Yasunaga M, Kobayashi H, Wake N, Tsuneyoshi M
Oncol Rep. 2010
PubMed ID: 21042753
Expression of laminin gamma2 chain monomer enhances invasive growth of human carcinoma cells in vivo.
Tsubota Y, Ogawa T, Oyanagi J, Nagashima Y, Miyazaki K
Int J Cancer. 2010
PubMed ID: 20143393
ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells.
Drake JM, Barnes JM, Madsen JM, Domann FE, Stipp CS, Henry MD
J Biol Chem. 2010
PubMed ID: 20729552
The transcription factor GATA-6 regulates pathological cardiac hypertrophy.
van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2010
PubMed ID: 20705924
Histopathologic features of the tumor budding in adenocarcinoma of the lung: tumor budding as an index to predict the potential aggressiveness.
Yamaguchi Y, Ishii G, Kojima M, Yoh K, Otsuka H, Otaki Y, Aokage K, Yanagi S, Nagai K, Nishiwaki Y, Ochiai A
J Thorac Oncol. 2010
PubMed ID: 20631633
Gene expression and dental enamel structure in developing mouse incisor.
Sehic A, Risnes S, Khan QE, Khuu C, Osmundsen H
Eur J Oral Sci. 2010
PubMed ID: 20487000
A Mouse Model of Generalized Non-Herlitz Junctional Epidermolysis Bullosa.
Bubier JA, Sproule TJ, Alley LM, Webb CM, Fine JD, Roopenian DC, Sundberg JP
J Invest Dermatol. 2010
PubMed ID: 20336083
Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3-dependent keratinocyte motility.
Kariya Y, Kawamura C, Tabei T, Gu J
J Biol Chem. 2010
PubMed ID: 19940114
Uncoupled responses of Smad4-deficient cancer cells to TNFalpha result in secretion of monomeric laminin-gamma2.
Zboralski D, Warscheid B, Klein-Scory S, Malas MB, Becker H, Böckmann M, Meyer HE, Schmiegel W, Simon-Assmann P, Schwarte-Waldhoff I
Mol Cancer. 2010
PubMed ID: 20307265
Over-expression of thymosin beta 4 promotes abnormal tooth development and stimulation of hair growth.
Cha HJ, Philp D, Lee SH, Moon HS, Kleinman HK, Nakamura T
Int J Dev Biol. 2010
PubMed ID: 20013654
Prognostic role of vasculogenic mimicry in colorectal cancer.
Baeten CI, Hillen F, Pauwels P, de Bruine AP, Baeten CG
Dis Colon Rectum. 2009
PubMed ID: 19934926
Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model.
Lugassy C, Torres-Muñoz JE, Kleinman HK, Ghanem G, Vernon S, Barnhill RL
J Cutan Pathol. 2009
PubMed ID: 19469865
Overexpression of beta3/gamma2 chains of laminin-5 and MMP7 in biliary cancer.
Oka T, Yamamoto H, Sasaki S, Ii M, Hizaki K, Taniguchi H, Adachi Y, Imai K, Shinomura Y
World J Gastroenterol. 2009
PubMed ID: 19701966
Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells.
Yamamoto H, Kitadai Y, Yamamoto H, Oue N, Ohdan H, Yasui W, Kikuchi A
Gastroenterology. 2009
PubMed ID: 19582886
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Upregulation of gamma-2 laminin-332 in the mouse ear vesicant wound model.
Chang YC, Sabourin CL, Lu SE, Sasaki T, Svoboda KK, Gordon MK, Riley DJ, Casillas RP, Gerecke DR
J Biochem Mol Toxicol. 2009
PubMed ID: 19526566
A decreased ratio of laminin-332 beta3 to gamma2 subunit mRNA is associated with poor prognosis in colon cancer.
Guess CM, Lafleur BJ, Weidow BL, Quaranta V
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19383890
Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5).
Carpenter PM, Dao AV, Arain ZS, Chang MK, Nguyen HP, Arain S, Wang-Rodriguez J, Kwon SY, Wilczynski SP
Mol Cancer Res. 2009
PubMed ID: 19351903
Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse.
Sehic A, Khuu C, Risnes S, Osmundsen H
Eur J Oral Sci. 2009
PubMed ID: 19320717
Stromal laminin-5gamma2 chain expression is associated with the wall-invasion pattern of gallbladder adenocarcinoma.
Okada K, Kijima H, Imaizumi T, Hirabayashi K, Matsuyama M, Yazawa N, Oida Y, Dowaki S, Tobita K, Ohtani Y, Tanaka M, Inokuchi S, Makuuchi H
Biomed Res. 2009
PubMed ID: 19265264
Profiling bladder cancer organ site-specific metastasis identifies LAMC2 as a novel biomarker of hematogenous dissemination.
Smith SC, Nicholson B, Nitz M, Frierson HF, Smolkin M, Hampton G, El-Rifai W, Theodorescu D
Am J Pathol. 2009
PubMed ID: 19147813
Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin.
Margadant C, Raymond K, Kreft M, Sachs N, Janssen H, Sonnenberg A
J Cell Sci. 2009
PubMed ID: 19118220
Relation between laminin-5 gamma 2 chain and cell surface metalloproteinase MT1-MMP in clear cell carcinoma of the ovary.
Kato N, Motoyama T
Int J Gynecol Pathol. 2009
PubMed ID: 19047908
Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains.
Ido H, Ito S, Taniguchi Y, Hayashi M, Sato-Nishiuchi R, Sanzen N, Hayashi Y, Futaki S, Sekiguchi K
J Biol Chem. 2008
PubMed ID: 18697739
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
HIF1 transcription factor regulates laminin-332 expression and keratinocyte migration.
Fitsialos G, Bourget I, Augier S, Ginouvès A, Rezzonico R, Odorisio T, Cianfarani F, Virolle T, Pouysségur J, Meneguzzi G, Berra E, Ponzio G, Buscà R
J Cell Sci. 2008
PubMed ID: 18713836
Transcriptome-based systematic identification of extracellular matrix proteins.
Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18757743
Gene expression profiling identifies genes predictive of oral squamous cell carcinoma.
Chen C, Méndez E, Houck J, Fan W, Lohavanichbutr P, Doody D, Yueh B, Futran ND, Upton M, Farwell DG, Schwartz SM, Zhao LP
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18669583
Expression and chain assembly of human laminin-332 in an insect cell-free translation system.
Phan HP, Ezure T, Ito M, Kadowaki T, Kitagawa Y, Niimi T
Biosci Biotechnol Biochem. 2008
PubMed ID: 18603785
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
Shou JZ, Hu N, Takikita M, Roth MJ, Johnson LL, Giffen C, Wang QH, Wang C, Wang Y, Su H, Kong LH, Emmert-Buck MR, Goldstein AM, Hewitt SM, Taylor PR
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18559558
A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.
Brinkman MB, McGill MA, Pettersson J, Rogers A, Matejková P, Smajs D, Weinstock GM, Norris SJ, Palzkill T
Infect Immun. 2008
PubMed ID: 18332212
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Prognostic value of differential expression of Laminin-5 gamma2 in oral squamous cell carcinomas: correlation with survival.
Gasparoni A, Della Casa M, Milillo L, Lorenzini G, Rubini C, Urso R, Lo Muzio L
Oncol Rep. 2007
PubMed ID: 17786338
Laminin isoforms in development and disease.
Schéele S, Nyström A, Durbeej M, Talts JF, Ekblom M, Ekblom P
J Mol Med. 2007
PubMed ID: 17426950
The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.
Pakuts B, Debonneville C, Liontos LM, Loreto MP, McGlade CJ
J Biol Chem. 2007
PubMed ID: 17353186
Mesenchymal cells contribute to the synthesis and deposition of the laminin-5 gamma2 chain in the invasive front of oral squamous cell carcinoma.
Franz M, Richter P, Geyer C, Hansen T, Acuña LD, Hyckel P, Böhmer FD, Kosmehl H, Berndt A
J Mol Histol. 2007
PubMed ID: 17390227
The short arm of laminin gamma2 chain of laminin-5 (laminin-332) binds syndecan-1 and regulates cellular adhesion and migration by suppressing phosphorylation of integrin beta4 chain.
Ogawa T, Tsubota Y, Hashimoto J, Kariya Y, Miyazaki K
Mol Biol Cell. 2007
PubMed ID: 17314405
Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.
Evsikov AV, Graber JH, Brockman JM, Hampl A, Holbrook AE, Singh P, Eppig JJ, Solter D, Knowles BB
Genes Dev. 2006
PubMed ID: 17015433
Laminin 5 regulates polycystic kidney cell proliferation and cyst formation.
Joly D, Berissi S, Bertrand A, Strehl L, Patey N, Knebelmann B
J Biol Chem. 2006
PubMed ID: 16870608
Expression of type XXIII collagen mRNA and protein.
Koch M, Veit G, Stricker S, Bhatt P, Kutsch S, Zhou P, Reinders E, Hahn RA, Song R, Burgeson RE, Gerecke DR, Mundlos S, Gordon MK
J Biol Chem. 2006
PubMed ID: 16728390
Current insights into the formation and breakdown of hemidesmosomes.
Litjens SH, de Pereda JM, Sonnenberg A
Trends Cell Biol. 2006
PubMed ID: 16757171
Expression of plasminogen activator inhibitor-1, urokinase receptor and laminin gamma-2 chain is an early coordinated event in incipient oral squamous cell carcinoma.
Lindberg P, Larsson A, Nielsen BS
Int J Cancer. 2006
PubMed ID: 16395714
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.
Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT
Hum Mol Genet. 2006
PubMed ID: 16537572
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.
Wu X, Quondamatteo F, Lefever T, Czuchra A, Meyer H, Chrostek A, Paus R, Langbein L, Brakebusch C
Genes Dev. 2006
PubMed ID: 16510873
Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium.
Tanno M, Hashimoto S, Muramatsu T, Matsuki M, Yamada S, Shimono M
J Periodontal Res. 2006
PubMed ID: 16409251
Lung development in laminin gamma2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation.
Nguyen NM, Pulkkinen L, Schlueter JA, Meneguzzi G, Uitto J, Senior RM
Respir Res. 2006
PubMed ID: 16483354
Conjugation of LG domains of agrins and perlecan to polymerizing laminin-2 promotes acetylcholine receptor clustering.
Smirnov SP, Barzaghi P, McKee KK, Ruegg MA, Yurchenco PD
J Biol Chem. 2005
PubMed ID: 16219760
Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma.
Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S
Gastroenterology. 2005
PubMed ID: 16285938
Laminin-5 suppresses chondrogenic differentiation of murine teratocarcinoma cell line ATDC5.
Hashimoto J, Ogawa T, Tsubota Y, Miyazaki K
Exp Cell Res. 2005
PubMed ID: 16165127
Suppression of laminin-5 expression leads to increased motility, tumorigenicity, and invasion.
Yuen HW, Ziober AF, Gopal P, Nasrallah I, Falls EM, Meneguzzi G, Ang HQ, Ziober BL
Exp Cell Res. 2005
PubMed ID: 15963983
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Basement membrane composition in the early mouse embryo day 7.
Gersdorff N, Müller M, Otto S, Poschadel R, Hübner S, Miosge N
Dev Dyn. 2005
PubMed ID: 15895400
Quantitative analysis of laminin 5 gene expression in human keratinocytes.
Akutsu N, Amano S, Nishiyama T
Exp Dermatol. 2005
PubMed ID: 15854126
Basement membrane distortions impair lung lobation and capillary organization in the mouse model for fraser syndrome.
Petrou P, Pavlakis E, Dalezios Y, Galanopoulos VK, Chalepakis G
J Biol Chem. 2005
PubMed ID: 15623520
Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 gamma 2 correlates with the invasiveness of human glioma.
Guo P, Imanishi Y, Cackowski FC, Jarzynka MJ, Tao HQ, Nishikawa R, Hirose T, Hu B, Cheng SY
Am J Pathol. 2005
PubMed ID: 15743799
Correlation between laminin-5 gamma2 chain and epidermal growth factor receptor expression in esophageal squamous cell carcinomas.
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Oncology. 2005
PubMed ID: 16103736
Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation.
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Dev Biol. 2005
PubMed ID: 15572153
Distribution of basement membrane anchoring molecules in normal and transformed endometrium: altered expression of laminin gamma2 chain and collagen type XVII in endometrial adenocarcinomas.
Määttä M, Salo S, Tasanen K, Soini Y, Liakka A, Bruckner-Tuderman L, Autio-Harmainen H
J Mol Histol. 2004
PubMed ID: 15609083
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Laminin-5 mutational analysis in an Italian cohort of patients with junctional epidermolysis bullosa.
Posteraro P, De Luca N, Meneguzzi G, El Hachem M, Angelo C, Gobello T, Tadini G, Zambruno G, Castiglia D
J Invest Dermatol. 2004
PubMed ID: 15373767
Laminin 5 beta3 and gamma2 chains are frequently coexpressed in cancer cells.
Akimoto S, Nakanishi Y, Sakamoto M, Kanai Y, Hirohashi S
Pathol Int. 2004
PubMed ID: 15363037
Aberrant expression of laminin gamma 2 chain and its prognostic significance in intrahepatic cholangiocarcinoma according to growth morphology.
Aishima S, Matsuura S, Terashi T, Taguchi K, Shimada M, Maehara Y, Tsuneyoshi M
Mod Pathol. 2004
PubMed ID: 15105812
Fibroblasts contribute to the deposition of laminin 5 in the extracellular matrix.
Elkhal A, Tunggal L, Aumailley M
Exp Cell Res. 2004
PubMed ID: 15149852
Evaluation of the ARMD1 locus on 1q25-31 in patients with age-related maculopathy: genetic variation in laminin genes and in exon 104 of HEMICENTIN-1.
Hayashi M, Merriam JE, Klaver CC, Zernant J, Bergen AA, Smith RT, Chang S, Merriam JC, Allikmets R
Ophthalmic Genet. 2004
PubMed ID: 15370542
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
A direct functional link between the multi-PDZ domain protein GRIP1 and the Fraser syndrome protein Fras1.
Takamiya K, Kostourou V, Adams S, Jadeja S, Chalepakis G, Scambler PJ, Huganir RL, Adams RH
Nat Genet. 2004
PubMed ID: 14730302
Thymosin beta 4 stimulates laminin-5 production independent of TGF-beta.
Sosne G, Xu L, Prach L, Mrock LK, Kleinman HK, Letterio JJ, Hazlett LD, Kurpakus-Wheater M
Exp Cell Res. 2004
PubMed ID: 14729067
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa.
Meng X, Klement JF, Leperi DA, Birk DE, Sasaki T, Timpl R, Uitto J, Pulkkinen L
J Invest Dermatol. 2003
PubMed ID: 14632187
Laminin alpha5 chain is required for intestinal smooth muscle development.
Bolcato-Bellemin AL, Lefebvre O, Arnold C, Sorokin L, Miner JH, Kedinger M, Simon-Assmann P
Dev Biol. 2003
PubMed ID: 12921739
Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus.
Fontao L, Favre B, Riou S, Geerts D, Jaunin F, Saurat JH, Green KJ, Sonnenberg A, Borradori L
Mol Biol Cell. 2003
PubMed ID: 12802069
Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells.
Olsen J, Kirkeby LT, Brorsson MM, Dabelsteen S, Troelsen JT, Bordoy R, Fenger K, Larsson LI, Simon-Assmann P
Biochem J. 2003
PubMed ID: 12519076
Laminin-5 gamma2 chain expression as a possible determinant of tumor aggressiveness in T1 colorectal carcinomas.
Masaki T, Matsuoka H, Sugiyama M, Abe N, Izumisato Y, Sakamoto A, Atomi Y
Dig Dis Sci. 2003
PubMed ID: 12643602
Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development.
Mill P, Mo R, Fu H, Grachtchouk M, Kim PC, Dlugosz AA, Hui CC
Genes Dev. 2003
PubMed ID: 12533516
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
Koster J, Geerts D, Favre B, Borradori L, Sonnenberg A
J Cell Sci. 2003
PubMed ID: 12482924
Laminin gamma2-chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion.
Katayama M, Sanzen N, Funakoshi A, Sekiguchi K
Cancer Res. 2003
PubMed ID: 12517801
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
Initial sequencing and comparative analysis of the mouse genome.
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Nature. 2002
PubMed ID: 12466850
Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse.
Spirito F, Charlesworth A, Linder K, Ortonne JP, Baird J, Meneguzzi G
J Invest Dermatol. 2002
PubMed ID: 12230513
Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.
Patel V, Aldridge K, Ensley JF, Odell E, Boyd A, Jones J, Gutkind JS, Yeudall WA
Int J Cancer. 2002
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Cytoplasmic expression of laminin gamma2 chain correlates with postoperative hepatic metastasis and poor prognosis in patients with pancreatic ductal adenocarcinoma.
Takahashi S, Hasebe T, Oda T, Sasaki S, Kinoshita T, Konishi M, Ochiai T, Ochiai A
Cancer. 2002
PubMed ID: 11920553
Correlation between laminin-5 gamma2 chain expression and epidermal growth factor receptor expression and its clinicopathological significance in squamous cell carcinoma of the tongue.
Katoh K, Nakanishi Y, Akimoto S, Yoshimura K, Takagi M, Sakamoto M, Hirohashi S
Oncology. 2002
PubMed ID: 12138239
Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes.
Nakano A, Chao SC, Pulkkinen L, Murrell D, Bruckner-Tuderman L, Pfendner E, Uitto J
Hum Genet. 2002
PubMed ID: 11810295
Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R
J Mol Biol. 2001
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Immunohistochemical distribution of laminin-5 gamma2 chain and its developmental change in human embryonic and foetal tissues.
Lu W, Miyazaki K, Mizushima H, Nemoto N
Histochem J. 2001
PubMed ID: 12197671
Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.
Klaffky E, Williams R, Yao CC, Ziober B, Kramer R, Sutherland A
Dev Biol. 2001
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Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor.
Kieffer-Combeau S, Meyer JM, Lesot H
Int J Dev Biol. 2001
PubMed ID: 11669375
Novel mutations in the LAMC2 gene in non-Herlitz junctional epidermolysis bullosa: effects on laminin-5 assembly, secretion, and deposition.
Castiglia D, Posteraro P, Spirito F, Pinola M, Angelo C, Puddu P, Meneguzzi G, Zambruno G
J Invest Dermatol. 2001
PubMed ID: 11564184
Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.
McArthur CP, Wang Y, Heruth D, Gustafson S
Arch Oral Biol. 2001
PubMed ID: 11311202
Reduced expression of the epithelial adhesion ligand laminin 5 in the skin causes intradermal tissue separation.
Spirito F, Chavanas S, Prost-Squarcioni C, Pulkkinen L, Fraitag S, Bodemer C, Ortonne JP, Meneguzzi G
J Biol Chem. 2001
PubMed ID: 11279058
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Differential expression of the LAMB3 and LAMC2 genes between small cell and non-small cell lung carcinomas.
Manda R, Kohno T, Niki T, Yamada T, Takenoshita S, Kuwano H, Yokota J
Biochem Biophys Res Commun. 2000
PubMed ID: 10964684
Mutation report: complete paternal uniparental isodisomy of chromosome 1: a novel mechanism for Herlitz junctional epidermolysis bullosa.
Takizawa Y, Pulkkinen L, Chao SC, Nakajima H, Nakano Y, Shimizu H, Uitto J
J Invest Dermatol. 2000
PubMed ID: 10951251
Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain.
Amano S, Scott IC, Takahara K, Koch M, Champliaud MF, Gerecke DR, Keene DR, Hudson DL, Nishiyama T, Lee S, Greenspan DS, Burgeson RE
J Biol Chem. 2000
PubMed ID: 10806203
Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5.
Hirosaki T, Mizushima H, Tsubota Y, Moriyama K, Miyazaki K
J Biol Chem. 2000
PubMed ID: 10801807
The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.
Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A
J Cell Biol. 2000
PubMed ID: 10811835
Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin gamma2-chain gene promoter by hepatocyte growth factor (scatter factor).
Olsen J, Lefebvre O, Fritsch C, Troelsen JT, Orian-Rousseau V, Kedinger M, Simon-Assmann P
Biochem J. 2000
PubMed ID: 10749670
Differential expression of laminin-5 subunits during incisor and molar development in the mouse.
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Int J Dev Biol. 2000
PubMed ID: 10853832
Differential expression of mouse laminin gamma2 and gamma2* chain transcripts.
Airenne T, Lin Y, Olsson M, Ekblom P, Vainio S, Tryggvason K
Cell Tissue Res. 2000
PubMed ID: 10805082
Inhibition of laminin-5 production in breast epithelial cells by overexpression of p300.
Miller KA, Chung J, Lo D, Jones JC, Thimmapaya B, Weitzman SA
J Biol Chem. 2000
PubMed ID: 10713141
The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.
Hopkinson SB, Jones JC
Mol Biol Cell. 2000
PubMed ID: 10637308
Localization of laminin-5, HD1/plectin, and BP230 in the submandibular glands of developing and adult mice.
Kadoya Y, Yamashina S
Histochem Cell Biol. 1999
PubMed ID: 10651091
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
An integrated somatic cell hybrid, YAC, and BAC map of the Rmc1 region of mouse chromosome 1.
Hunter K, Greenwood J, Yang YL, Cunningham JM, Birren B, Housman D
Genomics. 1999
PubMed ID: 10373331
Laminin-5 promotes adhesion and migration of epithelial cells: identification of a migration-related element in the gamma2 chain gene (LAMC2) with activity in transgenic mice.
Salo S, Haakana H, Kontusaari S, Hujanen E, Kallunki T, Tryggvason K
Matrix Biol. 1999
PubMed ID: 10372560
Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses.
Tailor CS, Nouri A, Lee CG, Kozak C, Kabat D
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9927670
NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats.
Chen M, Marinkovich MP, Jones JC, O'Toole EA, Li YY, Woodley DT
J Invest Dermatol. 1999
PubMed ID: 9989793
Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1.
Yang YL, Guo L, Xu S, Holland CA, Kitamura T, Hunter K, Cunningham JM
Nat Genet. 1999
PubMed ID: 9988277
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts.
Sahlberg C, Hormia M, Airenne T, Thesleff I
J Dent Res. 1998
PubMed ID: 9719032
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.
Murgia C, Blaikie P, Kim N, Dans M, Petrie HT, Giancotti FG
EMBO J. 1998
PubMed ID: 9670011
Expression and localization of laminin-5 subunits in the mouse incisor.
Yoshiba N, Yoshiba K, Aberdam D, Meneguzzi G, Perrin-Schmitt F, Stoetzel C, Ruch JV, Lesot H
Cell Tissue Res. 1998
PubMed ID: 9506922
Expression and localization of laminin-5 subunits during mouse tooth development.
Yoshiba K, Yoshiba N, Aberdam D, Meneguzzi G, Perrin-Schmitt F, Stoetzel C, Ruch JV, Lesot H
Dev Dyn. 1998
PubMed ID: 9489770
Wide distribution of laminin-5 gamma 2 chain in basement membranes of various human tissues.
Mizushima H, Koshikawa N, Moriyama K, Takamura H, Nagashima Y, Hirahara F, Miyazaki K
Horm Res. 1998
PubMed ID: 9721586
Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice.
Patton BL, Miner JH, Chiu AY, Sanes JR
J Cell Biol. 1997
PubMed ID: 9396756
Laminin alpha 5, a major transcript of normal and malignant rat liver epithelial cells, is differentially expressed in developing and adult liver.
Seebacher T, Medina JL, Bade EG
Exp Cell Res. 1997
PubMed ID: 9417868
IAP insertion in the murine LamB3 gene results in junctional epidermolysis bullosa.
Kuster JE, Guarnieri MH, Ault JG, Flaherty L, Swiatek PJ
Mamm Genome. 1997
PubMed ID: 9271670
Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.
Qin P, Piechocki M, Lu S, Kurpakus MA
Dev Dyn. 1997
PubMed ID: 9264260
Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons.
Lentz SI, Miner JH, Sanes JR, Snider WD
J Comp Neurol. 1997
PubMed ID: 9034910
Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors.
Mizushima H, Miyagi Y, Kikkawa Y, Yamanaka N, Yasumitsu H, Misugi K, Miyazaki K
J Biochem. 1996
PubMed ID: 9010770
Genetic mapping of the laminin gamma 2 gene on sheep chromosome 12.
Jenkins ZA, Montgomery GW
Mamm Genome. 1996
PubMed ID: 8875904
Passive transfer of anti-laminin 5 antibodies induces subepidermal blisters in neonatal mice.
Lazarova Z, Yee C, Darling T, Briggaman RA, Yancey KB
J Clin Invest. 1996
PubMed ID: 8833897
Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage.
Yotsumoto S, Fujiwara H, Horton JH, Mosby TA, Wang X, Cui Y, Ko MS
Hum Mol Genet. 1996
PubMed ID: 8872465
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.
Dowling J, Yu QC, Fuchs E
J Cell Biol. 1996
PubMed ID: 8707838
Genetic mapping of the gene encoding the alpha1 subunit of neuronal calcium channels.
Lyu M, Kozak CA, Chin H
Mamm Genome. 1996
PubMed ID: 8661716
Structure of the human laminin gamma 2 chain gene (LAMC2): alternative splicing with different tissue distribution of two transcripts.
Airenne T, Haakana H, Sainio K, Kallunki T, Kallunki P, Sariola H, Tryggvason K
Genomics. 1996
PubMed ID: 8786121
Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.
Kozak CA, Adamson MC, Buckler CE, Segovia L, Paralkar V, Wistow G
Genomics. 1995
PubMed ID: 7558020
Mouse kalinin B1 (laminin beta 3 chain): cloning and tissue distribution.
Utani A, Kopp JB, Kozak CA, Matsuki Y, Amizuka N, Sugiyama S, Yamada Y
Lab Invest. 1995
PubMed ID: 7898049
Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a subunit of epithelial cell laminin.
Sugiyama S, Utani A, Yamada S, Kozak CA, Yamada Y
Eur J Biochem. 1995
PubMed ID: 7882992
A novel homozygous nonsense mutation in the LAMC2 gene in patients with the Herlitz junctional epidermolysis bullosa.
Baudoin C, Miquel C, Gagnoux-Palacios L, Pulkkinen L, Christiano AM, Uitto J, Tadini G, Ortonne JP, Meneguzzi G
Hum Mol Genet. 1994
PubMed ID: 7849725
Junctional epidermolysis bullosa inversa (locus EBR2A) assigned to 1q31 by linkage and association to LAMC1.
Gedde-Dahl T, Dupuy BM, Jonassen R, Winberg JO, Anton-Lamprecht I, Olaisen B
Hum Mol Genet. 1994
PubMed ID: 7987320
Developmental expression of nicein adhesion protein (laminin-5) subunits suggests multiple morphogenic roles.
Aberdam D, Aguzzi A, Baudoin C, Galliano MF, Ortonne JP, Meneguzzi G
Cell Adhes Commun. 1994
PubMed ID: 8081888
Assignment of mouse nicein genes to chromosomes 1 and 18.
Aberdam D, Galliano MF, Mattei MG, Pisani-Spadafora A, Ortonne JP, Meneguzzi G
Mamm Genome. 1994
PubMed ID: 8012114
A new nomenclature for the laminins.
Burgeson RE, Chiquet M, Deutzmann R, Ekblom P, Engel J, Kleinman H, Martin GR, Meneguzzi G, Paulsson M, Sanes J
Matrix Biol. 1994
PubMed ID: 7921537
Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the gamma 2 subunit of nicein/kalinin (LAMININ-5).
Aberdam D, Galliano MF, Vailly J, Pulkkinen L, Bonifas J, Christiano AM, Tryggvason K, Uitto J, Epstein EH, Ortonne JP
Nat Genet. 1994
PubMed ID: 8012394
Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa.
Pulkkinen L, Christiano AM, Airenne T, Haakana H, Tryggvason K, Uitto J
Nat Genet. 1994
PubMed ID: 8012393
Herlitz junctional epidermolysis bullosa keratinocytes display heterogeneous defects of nicein/kalinin gene expression.
Baudoin C, Miquel C, Blanchet-Bardon C, Gambini C, Meneguzzi G, Ortonne JP
J Clin Invest. 1994
PubMed ID: 8113417
The 100-kDa chain of nicein/kalinin is a laminin B2 chain variant.
Vailly J, Verrando P, Champliaud MF, Gerecke D, Wagman DW, Baudoin C, Aberdam D, Burgeson R, Bauer E, Ortonne JP
Eur J Biochem. 1994
PubMed ID: 8306988
A large cell-adhesive scatter factor secreted by human gastric carcinoma cells.
Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8265624
A truncated laminin chain homologous to the B2 chain: structure, spatial expression, and chromosomal assignment.
Kallunki P, Sainio K, Eddy R, Byers M, Kallunki T, Sariola H, Beck K, Hirvonen H, Shows TB, Tryggvason K
J Cell Biol. 1992
PubMed ID: 1383240

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:99913	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3918	16782	192362
EnsEMBL Gene(s)	ENSG00000058085	ENSMUSG00000026479	ENSRNOG00000002667
Unigene	Hs.591484	Mm.329272	Rn.9278
Homologene	LAMC2	Lamc2	Lamc2
OMIM	150292	N/A	N/A
GeneCards	LAMC2	N/A	N/A
Beta Cell Genomics	DT.100790806 DT.442299	DT.101364278 DT.529609 DT.91309714 DT.97357086 DT.97391019	N/A
Reactome	Q13753	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:99913	N/A
WikiGenes	3918	16782	192362

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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