RHOA

Summary Top Help

Gene Description:

ras homolog gene family, member A; ras homolog family member A

Synonyms:

Arha, RHO12, RHOA, Rhoa, ARH12, ARHA, Arha2, RHOH12, Arha1

Orthologs:

Human RHOA (protein-coding), Mouse Rhoa (protein-coding), Rat Rhoa (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm3	Rat	chr2:197256223..242256223	45.00	281

Other Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm26	Rat	chr2:181710214..222281918	40.57	425

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr3:49396578..49450431 (53.85 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:108208536..108240270 (31.73 kb) View in Genome Browser

(Rat) RGSC3.4 - chr2:200048040..200054101 (66 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for RHOA:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for RHOA:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 19

Biocarta: 15

Reactome: 24

NCI-Nature Pathway Interaction Database: 47

Gene Ontology: 53

Nucleotide binding	GO:0000166
Cell morphogenesis	GO:0000902
GTPase activity	GO:0003924
Protein binding	GO:0005515
GTP binding	GO:0005525
Intracellular	GO:0005622
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Cytosol	GO:0005829
Cytoskeleton	GO:0005856
Plasma membrane	GO:0005886
Cell cortex	GO:0005938
GTP catabolic process	GO:0006184
Regulation of transcription from RNA polymerase II promoter	GO:0006357
Cell cycle	GO:0007049
Cell adhesion	GO:0007155
Cell-matrix adhesion	GO:0007160
Small GTPase mediated signal transduction	GO:0007264
Rho protein signal transduction	GO:0007266
Axon guidance	GO:0007411
Skeletal muscle tissue development	GO:0007519
Blood coagulation	GO:0007596
Myosin binding	GO:0017022
Actin cytoskeleton organization	GO:0030036
Cell differentiation	GO:0030154
Platelet activation	GO:0030168
Regulation of cell migration	GO:0030334
Midbody	GO:0030496
Androgen receptor signaling pathway	GO:0030521
Cleavage furrow	GO:0032154
Ruffle membrane	GO:0032587
Negative regulation of intracellular steroid hormone receptor signaling pathway	GO:0033144
Regulation of osteoblast proliferation	GO:0033688
Positive regulation of NF-kappaB import into nucleus	GO:0042346
Positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:0043123
Apical junction complex	GO:0043296
Apical junction assembly	GO:0043297
Negative regulation of neuron apoptosis	GO:0043524
Ossification involved in bone maturation	GO:0043931
Interspecies interaction between organisms	GO:0044419
Positive regulation of neuron differentiation	GO:0045666
Nerve growth factor receptor signaling pathway	GO:0048011
Phosphatidylinositol-mediated signaling	GO:0048015
Regulation of axonogenesis	GO:0050770
Negative regulation of axonogenesis	GO:0050771
Positive regulation of axonogenesis	GO:0050772
Regulation of small GTPase mediated signal transduction	GO:0051056
Cell division	GO:0051301
Positive regulation of stress fiber assembly	GO:0051496
Trabecula morphogenesis	GO:0061383
Positive regulation of cell cycle cytokinesis	GO:0071777
Spindle assembly involved in mitosis	GO:0090307

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 882

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.
Badgwell DB, Lu Z, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC
Oncogene. 2012
PubMed ID: 21643014
PRL-1 protein promotes ERK1/2 and RhoA protein activation through a non-canonical interaction with the Src homology 3 domain of p115 Rho GTPase-activating protein.
Bai Y, Luo Y, Liu S, Zhang L, Shen K, Dong Y, Walls CD, Quilliam LA, Wells CD, Cao Y, Zhang ZY
J Biol Chem. 2011
PubMed ID: 22009749
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination.
Plageman TF, Chauhan BK, Yang C, Jaudon F, Shang X, Zheng Y, Lou M, Debant A, Hildebrand JD, Lang RA
Development. 2011
PubMed ID: 22031541
Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway.
Chen Z, Wang X, Shao Y, Shi D, Chen T, Cui D, Jiang X
Mol Cell Biochem. 2011
PubMed ID: 21739156
Impaired Rho GTPase activation abrogates cell polarization and migration in macrophages with defective lipolysis.
Aflaki E, Balenga NA, Luschnig-Schratl P, Wolinski H, Povoden S, Chandak PG, Bogner-Strauss JG, Eder S, Konya V, Kohlwein SD, Heinemann A, Kratky D
Cell Mol Life Sci. 2011
PubMed ID: 21533980
Balanced Rac1 and RhoA activities regulate cell shape and drive invagination morphogenesis in epithelia.
Chauhan BK, Lou M, Zheng Y, Lang RA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22021442
RhoA GTPase regulates radiation-induced alterations in endothelial cell adhesion and migration.
Rousseau M, Gaugler MH, Rodallec A, Bonnaud S, Paris F, Corre I
Biochem Biophys Res Commun. 2011
PubMed ID: 22001926
Role of epimorphin in bile duct formation of rat liver epithelial stem-like cells: involvement of small G protein RhoA and C/EBPβ.
Jia Y, Yao H, Zhou J, Chen L, Zeng Q, Yuan H, Shi L, Nan X, Wang Y, Yue W, Pei X
J Cell Physiol. 2011
PubMed ID: 21935930
Intermedin induces loss of coronary microvascular endothelial barrier via derangement of actin cytoskeleton: role of RhoA and Rac1.
Aslam M, Gündüz D, Schuler D, Li L, Sharifpanah F, Sedding D, Piper HM, Noll T
Cardiovasc Res. 2011
PubMed ID: 21816966
HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients.
Lin H, Xiao Y, Chen G, Fu D, Ye Y, Liang L, Fan J, Yang X, Sun L, Xu H
Rheumatol Int. 2011
PubMed ID: 20473500
Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity.
Soong G, Martin FJ, Chun J, Cohen TS, Ahn DS, Prince A
J Biol Chem. 2011
PubMed ID: 21878647
Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF.
Bielnicki JA, Shkumatov AV, Derewenda U, Somlyo AV, Svergun DI, Derewenda ZS
J Biol Chem. 2011
PubMed ID: 21816819
RhoA/ROCK signaling mediates plasticity of scirrhous gastric carcinoma motility.
Matsuoka T, Yashiro M, Kato Y, Shinto O, Kashiwagi S, Hirakawa K
Clin Exp Metastasis. 2011
PubMed ID: 21667311
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Choi HJ, Lee DH, Park SH, Kim J, Do KH, An TJ, Ahn YS, Park CB, Moon Y
Biochem Biophys Res Commun. 2011
PubMed ID: 21907186
Activation of RhoA in podocytes induces focal segmental glomerulosclerosis.
Zhu L, Jiang R, Aoudjit L, Jones N, Takano T
J Am Soc Nephrol. 2011
PubMed ID: 21804090
RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
Giang Ho TT, Stultiens A, Dubail J, Lapière CM, Nusgens BV, Colige AC, Deroanne CF
Mol Biol Cell. 2011
PubMed ID: 21757538
VEGF-C differentially regulates VEGF-A expression in ocular and cancer cells; promotes angiogenesis via RhoA mediated pathway.
Kumar B, Chile SA, Ray KB, Reddy GE, Addepalli MK, Kumar AS, Ramana V, Rajagopal V
Angiogenesis. 2011
PubMed ID: 21698469
Antioxidants prevent the RhoA inhibition evoked by crocidolite asbestos in human mesothelial and mesothelioma cells.
Aldieri E, Riganti C, Silvagno F, Orecchia S, Betta PG, Doublier S, Gazzano E, Polimeni M, Bosia A, Ghigo D
Am J Respir Cell Mol Biol. 2011
PubMed ID: 21257924
The atypical Guanine-nucleotide exchange factor, dock7, negatively regulates schwann cell differentiation and myelination.
Yamauchi J, Miyamoto Y, Hamasaki H, Sanbe A, Kusakawa S, Nakamura A, Tsumura H, Maeda M, Nemoto N, Kawahara K, Torii T, Tanoue A
J Neurosci. 2011
PubMed ID: 21880919
RhoA and NF-κB are involved in lipopolysaccharide-induced brain microvascular cell line hyperpermeability.
He F, Peng J, Deng XL, Yang LF, Wu LW, Zhang CL, Yin F
Neuroscience. 2011
PubMed ID: 21575689
Aldosterone induction of hepatic stellate cell contraction through activation of RhoA/ROCK-2 signaling pathway.
Ji H, Meng Y, Zhang X, Luo W, Wu P, Xiao B, Zhang Z, Li X
Regul Pept. 2011
PubMed ID: 21545816
Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice.
Harrod JS, Rada CC, Pierce SL, England SK, Lamping KG
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21558549
Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPase.
Li W, Zhang Y, Bouley R, Chen Y, Matsuzaki T, Nunes P, Hasler U, Brown D, Lu HA
Am J Physiol Renal Physiol. 2011
PubMed ID: 21511701
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
Tian M, Bai C, Lin Q, Lin H, Liu M, Ding F, Wang HR
FEBS Lett. 2011
PubMed ID: 21708152
Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.
Bongmba OY, Martinez LA, Elhardt ME, Butler K, Tejada-Simon MV
Brain Res. 2011
PubMed ID: 21645877
Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.
Wu C, Agrawal S, Vasanji A, Drazba J, Sarkaria S, Xie J, Welch CM, Liu M, Anand-Apte B, Horowitz A
J Biol Chem. 2011
PubMed ID: 21543326
Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells.
Shum WW, Da Silva N, Belleannée C, McKee M, Brown D, Breton S
Am J Physiol Cell Physiol. 2011
PubMed ID: 21411727
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.
Tkachenko E, Sabouri-Ghomi M, Pertz O, Kim C, Gutierrez E, Machacek M, Groisman A, Danuser G, Ginsberg MH
Nat Cell Biol. 2011
PubMed ID: 21572420
Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules.
Georgas KM, Chiu HS, Lesieur E, Rumballe BA, Little MH
Dev Dyn. 2011
PubMed ID: 21491542
Reactive oxygen species-dependent RhoA activation mediates collagen synthesis in hyperoxic lung fibrosis.
Kondrikov D, Caldwell RB, Dong Z, Su Y
Free Radic Biol Med. 2011
PubMed ID: 21439370
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Canet B, Pons C, Espinosa I, Prat J
Hum Pathol. 2011
PubMed ID: 21208644
[Effects of inhibiting RhoA by Stealth RNA on high glucose-induced RhoA/ROCK signaling pathway in human mesangial cells].
Ma DW, Wang QY, Chen QG, Wu D, Wang J, Hou LL
Zhonghua Yi Xue Za Zhi. 2011
PubMed ID: 21756816
Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability.
Siddiqui MR, Komarova YA, Vogel SM, Gao X, Bonini MG, Rajasingh J, Zhao YY, Brovkovych V, Malik AB
J Cell Biol. 2011
PubMed ID: 21624953
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Naji L, Pacholsky D, Aspenström P
Biochem Biophys Res Commun. 2011
PubMed ID: 21565175
Metabotropic regulation of RhoA/Rho-associated kinase by L-type Ca2+ channels: new mechanism for depolarization-evoked mammalian arterial contraction.
Fernández-Tenorio M, Porras-González C, Castellano A, Del Valle-Rodríguez A, López-Barneo J, Ureña J
Circ Res. 2011
PubMed ID: 21493898
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets.
Vega FM, Fruhwirth G, Ng T, Ridley AJ
J Cell Biol. 2011
PubMed ID: 21576392
The cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity.
Zieba BJ, Artamonov MV, Jin L, Momotani K, Ho R, Franke AS, Neppl RL, Stevenson AS, Khromov AS, Chrzanowska-Wodnicka M, Somlyo AV
J Biol Chem. 2011
PubMed ID: 21454546
Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation.
Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21502507
Hax1 regulates neutrophil adhesion and motility through RhoA.
Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A
J Cell Biol. 2011
PubMed ID: 21518791
Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.
Ocaña-Morgner C, Reichardt P, Chopin M, Braungart S, Wahren C, Gunzer M, Jessberger R
J Immunol. 2011
PubMed ID: 21421853
The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A.
Tu CL, Chang W, Bikle DD
J Invest Dermatol. 2011
PubMed ID: 21209619
Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.
Schlegel N, Meir M, Spindler V, Germer CT, Waschke J
J Cell Physiol. 2011
PubMed ID: 20945370
RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.
Melendez J, Stengel K, Zhou X, Chauhan BK, Debidda M, Andreassen P, Lang RA, Zheng Y
J Biol Chem. 2011
PubMed ID: 21454503
Activation of a RhoA/myosin II-dependent but Arp2/3 complex-independent pathway facilitates Salmonella invasion.
Hänisch J, Kölm R, Wozniczka M, Bumann D, Rottner K, Stradal TE
Cell Host Microbe. 2011
PubMed ID: 21501827
Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.
Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D
Biochemistry. 2011
PubMed ID: 21351730
SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.
Hamel B, Monaghan-Benson E, Rojas RJ, Temple BR, Marston DJ, Burridge K, Sondek J
J Biol Chem. 2011
PubMed ID: 21242305
GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.
Cullen M, Elzarrad MK, Seaman S, Zudaire E, Stevens J, Yang MY, Li X, Chaudhary A, Xu L, Hilton MB, Logsdon D, Hsiao E, Stein EV, Cuttitta F, Haines DC, Nagashima K, Tessarollo L, St Croix B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21421844
Continuous blood purification ameliorates RhoA-mediated endothelial permeability in severe acute pancreatitis patients with lung injury.
Du XG, Chen XM, Gan H, Li ZR, Wen YJ, Wang XC
Int J Artif Organs. 2011
PubMed ID: 21534245
Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis.
Yotova IY, Quan P, Leditznig N, Beer U, Wenzl R, Tschugguel W
Hum Reprod. 2011
PubMed ID: 21303778
RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.
Venkatesh D, Fredette N, Rostama B, Tang Y, Vary CP, Liaw L, Urs S
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21273559
Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts.
Verma SK, Lal H, Golden HB, Gerilechaogetu F, Smith M, Guleria RS, Foster DM, Lu G, Dostal DE
Cardiovasc Res. 2011
PubMed ID: 21131638
Heparin inhibits pulmonary artery smooth muscle cell proliferation through guanine nucleotide exchange factor-H1/RhoA/Rho kinase/p27.
Yu L, Quinn DA, Garg HG, Hales CA
Am J Respir Cell Mol Biol. 2011
PubMed ID: 20558775
RACK1 promotes breast carcinoma migration/metastasis via activation of the RhoA/Rho kinase pathway.
Cao XX, Xu JD, Xu JW, Liu XL, Cheng YY, Li QQ, Xu ZD, Liu XP
Breast Cancer Res Treat. 2011
PubMed ID: 20499158
The small GTPase RhoA is required to maintain spinal cord neuroepithelium organization and the neural stem cell pool.
Herzog D, Loetscher P, van Hengel J, Knüsel S, Brakebusch C, Taylor V, Suter U, Relvas JB
J Neurosci. 2011
PubMed ID: 21451048
PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.
Qadota H, Miyauchi T, Nahabedian JF, Stirman JN, Lu H, Amano M, Benian GM, Kaibuchi K
J Mol Biol. 2011
PubMed ID: 21277858
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling.
Pacary E, Heng J, Azzarelli R, Riou P, Castro D, Lebel-Potter M, Parras C, Bell DM, Ridley AJ, Parsons M, Guillemot F
Neuron. 2011
PubMed ID: 21435554
[Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis].
Liang LQ, Xiao YJ, Fu D, Lin HB, Yang YL, Ye YJ, Zhan ZP, Fan JJ, Yang XY, Xu HS
Zhonghua Yi Xue Za Zhi. 2011
PubMed ID: 21600098
The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.
Kakiashvili E, Dan Q, Vandermeer M, Zhang Y, Waheed F, Pham M, Szászi K
J Biol Chem. 2011
PubMed ID: 21212278
Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth.
Kouchi Z, Igarashi T, Shibayama N, Inanobe S, Sakurai K, Yamaguchi H, Fukuda T, Yanagi S, Nakamura Y, Fukami K
J Biol Chem. 2011
PubMed ID: 21187285
RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.
Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, Wang Z, Lefever T, Ochsenbein AM, Schmidt G, Aktories K, Stanley A, Quondamatteo F, Ladwein M, Rottner K, van Hengel J, Brakebusch C
Mol Biol Cell. 2011
PubMed ID: 21209320
RhoA-mediated signaling up-regulates hepatocyte growth factor gene and protein expression in response to apoptotic cells.
Park HJ, Choi YH, Cho YJ, Henson PM, Kang JL
J Leukoc Biol. 2011
PubMed ID: 21148681
Leptin-mediated cytoskeletal remodeling in chondrocytes occurs via the RhoA/ROCK pathway.
Liang J, Feng J, Wu WK, Xiao J, Wu Z, Han D, Zhu Y, Qiu G
J Orthop Res. 2011
PubMed ID: 20886658
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
Liu M, Lang N, Chen X, Tang Q, Liu S, Huang J, Zheng Y, Bi F
Cancer Lett. 2011
PubMed ID: 21186079
Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA.
Garcia MC, Williams J, Johnson K, Olden K, Roberts JD
FEBS Lett. 2011
PubMed ID: 21281639
An RNA-zipcode-independent mechanism that localizes Dia1 mRNA to the perinuclear ER through interactions between Dia1 nascent peptide and Rho-GTP.
Liao G, Ma X, Liu G
J Cell Sci. 2011
PubMed ID: 21266463
O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway.
Lima VV, Giachini FR, Carneiro FS, Carvalho MH, Fortes ZB, Webb RC, Tostes RC
Cardiovasc Res. 2011
PubMed ID: 20978008
Activation of vinculin induced by cholinergic stimulation regulates contraction of tracheal smooth muscle tissue.
Huang Y, Zhang W, Gunst SJ
J Biol Chem. 2011
PubMed ID: 21071443
Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth.
Zhang G, Lehmann HC, Manoharan S, Hashmi M, Shim S, Ming GL, Schnaar RL, Lopez PH, Bogdanova N, Sheikh KA
J Neurosci. 2011
PubMed ID: 21289175
Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.
Terry SJ, Zihni C, Elbediwy A, Vitiello E, Leefa Chong San IV, Balda MS, Matter K
Nat Cell Biol. 2011
PubMed ID: 21258369
Rho/Rho-kinase signaling pathway controls axon patterning of a specified subset of cranial motor neurons.
Kobayashi K, Masuda T, Takahashi M, Miyazaki J, Nakagawa M, Uchigashima M, Watanabe M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K
Eur J Neurosci. 2011
PubMed ID: 21219475
OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling.
Ryoo S, Bhunia A, Chang F, Shoukas A, Berkowitz DE, Romer LH
Atherosclerosis. 2011
PubMed ID: 21130456
p190 RhoGTPase-activating protein links the β1 integrin/caveolin-1 mechanosignaling complex to RhoA and actin remodeling.
Yang B, Radel C, Hughes D, Kelemen S, Rizzo V
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21051664
Chemopreventive effects of β-ionone and geraniol during rat hepatocarcinogenesis promotion: distinct actions on cell proliferation, apoptosis, HMGCoA reductase, and RhoA.
Cardozo MT, de Conti A, Ong TP, Scolastici C, Purgatto E, Horst MA, Bassoli BK, Moreno FS
J Nutr Biochem. 2011
PubMed ID: 20435455
A p27(kip1)-binding protein, p27RF-Rho, promotes cancer metastasis via activation of RhoA and RhoC.
Hoshino D, Koshikawa N, Seiki M
J Biol Chem. 2011
PubMed ID: 21087931
Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development.
Cheng PL, Lu H, Shelly M, Gao H, Poo MM
Neuron. 2011
PubMed ID: 21262463
Slit-2 repels the migration of olfactory ensheathing cells by triggering Ca2+-dependent cofilin activation and RhoA inhibition.
Huang ZH, Wang Y, Su ZD, Geng JG, Chen YZ, Yuan XB, He C
J Cell Sci. 2011
PubMed ID: 21187345
Suppression of bone formation by osteoclastic expression of semaphorin 4D.
Negishi-Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel RH, Takayanagi H
Nat Med. 2011
PubMed ID: 22019888
A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition.
Klein RM, Higgins PJ
Mol Cancer. 2011
PubMed ID: 21917148
Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCε.
Graziano F, Elia C, Laudanna C, Poli G, Alfano M
PLoS One. 2011
PubMed ID: 21858203
Interleukin-8 induces the endothelial cell migration through the activation of phosphoinositide 3-kinase-Rac1/RhoA pathway.
Lai Y, Shen Y, Liu XH, Zhang Y, Zeng Y, Liu YF
Int J Biol Sci. 2011
PubMed ID: 21750647
HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.
Ke L, Meijering RA, Hoogstra-Berends F, Mackovicova K, Vos MJ, Van Gelder IC, Henning RH, Kampinga HH, Brundel BJ
PLoS One. 2011
PubMed ID: 21731611
Crucial role of membrane type 1 matrix metalloproteinase (MT1- MMP) in RhoA/Rac1-dependent signaling pathways in thrombin- stimulated endothelial cells.
Ando K, Ishibashi T, Ohkawara H, Inoue N, Sugimoto K, Uekita H, Hu C, Okamoto Y, Takuwa Y, Takeishi Y
J Atheroscler Thromb. 2011
PubMed ID: 21628952
Rho GTPases in hematopoietic stem/progenitor cell migration.
Liu W, Feng Y, Shang X, Zheng Y
Methods Mol Biol. 2011
PubMed ID: 21618100
Dental enamel structure is altered by expression of dominant negative RhoA in ameloblasts.
Li Y, Pugach MK, Kuehl MA, Peng L, Bouchard J, Hwang SY, Gibson CW
Cells Tissues Organs. 2011
PubMed ID: 21576911
Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α.
Raheja LF, Genetos DC, Wong A, Yellowley CE
Cell Biol Int. 2011
PubMed ID: 21574962
Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction.
Peng J, He F, Zhang C, Deng X, Yin F
J Neuroinflammation. 2011
PubMed ID: 21473788
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.
Dubash AD, Guilluy C, Srougi MC, Boulter E, Burridge K, García-Mata R
PLoS One. 2011
PubMed ID: 21390328
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development. 2011
PubMed ID: 21177343
Adiponectin increases LPL activity via RhoA/ROCK-mediated actin remodelling in adult rat cardiomyocytes.
Ganguly R, Schram K, Fang X, Kim M, Rodrigues B, Thong FS, Sweeney G
Endocrinology. 2011
PubMed ID: 21147877
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.
Wallace SW, Magalhaes A, Hall A
Mol Cell Biol. 2011
PubMed ID: 20974804
Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration.
Zhang Z, Chometon G, Wen T, Qu H, Mauch C, Krieg T, Aumailley M
Eur J Cell Biol. 2011
PubMed ID: 20971525
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion.
Liu L, Das S, Losert W, Parent CA
Dev Cell. 2010
PubMed ID: 21145500
Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.
Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X, Huang S
J Biol Chem. 2010
PubMed ID: 20937815
Interplay of RhoA and motility in the programmed spreading of daughter cells postmitosis.
Mali P, Wirtz D, Searson PC
Biophys J. 2010
PubMed ID: 21112276
Effects of estrogen, raloxifene, and levormeloxifene on the expression of Rho-kinase signaling molecules in urethral smooth muscle cells.
Ning N, Lin G, Lue TF, Lin CS
Urology. 2010
PubMed ID: 20970835
RhoA and RhoC are both required for the ROCK II-dependent promotion of centrosome duplication.
Kanai M, Crowe MS, Zheng Y, Vande Woude GF, Fukasawa K
Oncogene. 2010
PubMed ID: 20697357
[The effect of hypoxia on the expression of RHO/RHO signaling pathway and CTGF of human embryonic fibroblasts].
Gao Y, Xie M, He ZP, Zhang X, Zheng JQ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2010
PubMed ID: 21265091
The transmembrane adaptor protein NTAL signals to mast cell cytoskeleton via the small GTPase Rho.
Tůmová M, Koffer A, Simíček M, Dráberová L, Dráber P
Eur J Immunol. 2010
PubMed ID: 21061444
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Carles M, Lafargue M, Goolaerts A, Roux J, Song Y, Howard M, Weston D, Swindle JT, Hedgpeth J, Burel-Vandenbos F, Pittet JF
Anesthesiology. 2010
PubMed ID: 20938335
A specific isoform of glial cell line-derived neurotrophic factor family receptor alpha 1 regulates RhoA expression and glioma cell migration.
Wan G, Too HP
J Neurochem. 2010
PubMed ID: 20807316
Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells.
Croucher DR, Rickwood D, Tactacan CM, Musgrove EA, Daly RJ
Mol Cell Biol. 2010
PubMed ID: 20805359
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
Margolis SS, Salogiannis J, Lipton DM, Mandel-Brehm C, Wills ZP, Mardinly AR, Hu L, Greer PL, Bikoff JB, Ho HY, Soskis MJ, Sahin M, Greenberg ME
Cell. 2010
PubMed ID: 21029865
Prolyl hydroxylase domain (PHD) 2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation.
Vogel S, Wottawa M, Farhat K, Zieseniss A, Schnelle M, Le-Huu S, von Ahlen M, Malz C, Camenisch G, Katschinski DM
J Biol Chem. 2010
PubMed ID: 20801873
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Zaoui K, Benseddik K, Daou P, Salaün D, Badache A
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20937854
The Lbc Rho guanine nucleotide exchange factor/{alpha}-catulin axis functions in serotonin-induced vascular smooth muscle cell mitogenesis and RhoA/ROCK activation.
Bear MD, Li M, Liu Y, Giel-Moloney MA, Fanburg BL, Toksoz D
J Biol Chem. 2010
PubMed ID: 20696764
Plakoglobin regulates cell motility through Rho- and fibronectin-dependent Src signaling.
Todorović V, Desai BV, Patterson MJ, Amargo EV, Dubash AD, Yin T, Jones JC, Green KJ
J Cell Sci. 2010
PubMed ID: 20876660
Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.
Tsuji T, Ohta Y, Kanno Y, Hirose K, Ohashi K, Mizuno K
Mol Biol Cell. 2010
PubMed ID: 20810787
Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells.
Pan H, Bachelder RE
Exp Cell Res. 2010
PubMed ID: 20655307
Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells.
Lim SM, Kreipe BA, Trzeciakowski J, Dangott L, Trache A
Exp Cell Res. 2010
PubMed ID: 20599954
Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network.
Fonseca AV, Freund D, Bornhäuser M, Corbeil D
J Biol Chem. 2010
PubMed ID: 20682776
Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency.
Henneman L, Schneiders MS, Turkenburg M, Waterham HR
J Inherit Metab Dis. 2010
PubMed ID: 20814828
RhoA protein is generally distributed in the nuclei of cancer cells.
Li Y, Chen Y, Tao Y, Xu J, Chen M
Oncol Rep. 2010
PubMed ID: 20811682
Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo.
Enciso JM, Konecny CM, Karpen HE, Hirschi KK
Dev Dyn. 2010
PubMed ID: 20737513
RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migration.
Rolli-Derkinderen M, Toumaniantz G, Pacaud P, Loirand G
Mol Cell Biol. 2010
PubMed ID: 20696841
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Mechanical strain-induced RhoA activation requires NADPH oxidase-mediated ROS generation in caveolae.
Zhang Y, Peng F, Gao B, Ingram AJ, Krepinsky JC
Antioxid Redox Signal. 2010
PubMed ID: 20380579
The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.
Zhou YT, Chew LL, Lin SC, Low BC
Mol Biol Cell. 2010
PubMed ID: 20660160
RhoA and DIAPH1 mediate adrenocorticotropin-stimulated cortisol biosynthesis by regulating mitochondrial trafficking.
Li D, Sewer MB
Endocrinology. 2010
PubMed ID: 20591975
RhoA-mediated potential regulation of blood-tumor barrier permeability by bradykinin.
Ma T, Xue Y
J Mol Neurosci. 2010
PubMed ID: 20369389
Altered expression of the small guanosine triphosphatase RhoA in human temporal lobe epilepsy.
Yuan J, Wang LY, Li JM, Cao NJ, Wang L, Feng GB, Xue T, Lu Y, Wang XF
J Mol Neurosci. 2010
PubMed ID: 20140537
Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration.
Heasman SJ, Carlin LM, Cox S, Ng T, Ridley AJ
J Cell Biol. 2010
PubMed ID: 20733052
Rho A and the Rho kinase pathway regulate fibroblast contraction: Enhanced contraction in constitutively active Rho A fibroblast cells.
Nobe K, Nobe H, Yoshida H, Kolodney MS, Paul RJ, Honda K
Biochem Biophys Res Commun. 2010
PubMed ID: 20655874
Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells.
Lee J, Moon HJ, Lee JM, Joo CK
J Biol Chem. 2010
PubMed ID: 20547485
Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA.
Godsel LM, Dubash AD, Bass-Zubek AE, Amargo EV, Klessner JL, Hobbs RP, Chen X, Green KJ
Mol Biol Cell. 2010
PubMed ID: 20554761
RhoA regulates calcium-independent periodic contractions of the cell cortex.
Costigliola N, Kapustina MT, Weinreb GE, Monteith A, Rajfur Z, Elston TC, Jacobson K
Biophys J. 2010
PubMed ID: 20712988
Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.
Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY, Zhang XM
J Clin Invest. 2010
PubMed ID: 20628200
The mechanism by which RhoA regulates vascular reactivity after hemorrhagic shock in rats.
Li T, Fang Y, Yang G, Zhu Y, Xu J, Liu L
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20472763
TM4SF5 accelerates G1/S phase progression via cytosolic p27Kip1 expression and RhoA activity.
Kim H, Kang M, Lee SA, Kwak TK, Jung O, Lee HJ, Kim SH, Lee JW
Biochim Biophys Acta. 2010
PubMed ID: 20399237
Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction.
Wang Z, Ginnan R, Abdullaev IF, Trebak M, Vincent PA, Singer HA
J Biol Chem. 2010
PubMed ID: 20442409
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
Sauzeau V, Berenjeno IM, Citterio C, Bustelo XR
Oncogene. 2010
PubMed ID: 20453885
The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.
Ordóñez-Morán P, Alvarez-Díaz S, Valle N, Larriba MJ, Bonilla F, Muñoz A
J Steroid Biochem Mol Biol. 2010
PubMed ID: 20223287
Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion.
Edelmann MJ, Kramer HB, Altun M, Kessler BM
FEBS J. 2010
PubMed ID: 20553488
Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers.
Wu M, Wu ZF, Rosenthal DT, Rhee EM, Merajver SD
Cancer. 2010
PubMed ID: 20503409
Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway.
Nethe M, Anthony EC, Fernandez-Borja M, Dee R, Geerts D, Hensbergen PJ, Deelder AM, Schmidt G, Hordijk PL
J Cell Sci. 2010
PubMed ID: 20460433
GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts.
Biz MT, Marques MR, Crema VO, Moriscot AS, dos Santos MF
Cell Tissue Res. 2010
PubMed ID: 20387077
The Rho pathway mediates transition to an alveolar type I cell phenotype during static stretch of alveolar type II cells.
Foster CD, Varghese LS, Gonzales LW, Margulies SS, Guttentag SH
Pediatr Res. 2010
PubMed ID: 20220547
Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry.
Klink BU, Barden S, Heidler TV, Borchers C, Ladwein M, Stradal TE, Rottner K, Heinz DW
J Biol Chem. 2010
PubMed ID: 20363740
Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.
Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
J Biol Chem. 2010
PubMed ID: 20348106
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20403997
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK
Nat Cell Biol. 2010
PubMed ID: 20383141
Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts.
Lutz R, Sakai T, Chiquet M
J Cell Sci. 2010
PubMed ID: 20375066
Role of the G-protein and tyrosine kinase--Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats.
Wang Y, Liang D, Wang S, Qiu Z, Chu X, Chen S, Li L, Nie X, Zhang R, Wang Z, Zhu D
J Biochem. 2010
PubMed ID: 20139061
The proximal STAT6 and NF-kappaB sites are responsible for IL-13- and TNF-alpha-induced RhoA transcriptions in human bronchial smooth muscle cells.
Goto K, Chiba Y, Matsusue K, Hattori Y, Maitani Y, Sakai H, Kimura S, Misawa M
Pharmacol Res. 2010
PubMed ID: 20006706
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, Conrad C, Comartin D, Schleiffer A, Sarov M, Pozniakovsky A, Slabicki MM, Schloissnig S, Steinmacher I, Leuschner M, Ssykor A, Lawo S, Pelletier L, Stark H, Nasmyth K, Ellenberg J, Durbin R, Buchholz F, Mechtler K, Hyman AA, Peters JM
Science. 2010
PubMed ID: 20360068
Rho-kinase inactivation prolongs survival of an intermediate SMA mouse model.
Bowerman M, Beauvais A, Anderson CL, Kothary R
Hum Mol Genet. 2010
PubMed ID: 20097679
Association analysis of 3p21 with Crohn's disease in a New Zealand population.
Morgan AR, Han DY, Lam WJ, Fraser AG, Ferguson LR
Hum Immunol. 2010
PubMed ID: 20307617
Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts.
Ding R, Hu DY, Xia K, Yang XC
Thorac Cardiovasc Surg. 2010
PubMed ID: 20376724
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD
Hum Mol Genet. 2010
PubMed ID: 20067919
RhoA/ROCK1 signaling regulates stress granule formation and apoptosis.
Tsai NP, Wei LN
Cell Signal. 2010
PubMed ID: 20004716
Role of calcium-independent phospholipase A2beta in high glucose-induced activation of RhoA, Rho kinase, and CPI-17 in cultured vascular smooth muscle cells and vascular smooth muscle hypercontractility in diabetic animals.
Xie Z, Gong MC, Su W, Xie D, Turk J, Guo Z
J Biol Chem. 2010
PubMed ID: 20086008
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
Local translation of dendritic RhoA revealed by an improved synaptoneurosome preparation.
Troca-Marín JA, Alves-Sampaio A, Tejedor FJ, Montesinos ML
Mol Cell Neurosci. 2010
PubMed ID: 20035871
CCK activates RhoA and Rac1 differentially through Galpha13 and Galphaq in mouse pancreatic acini.
Sabbatini ME, Bi Y, Ji B, Ernst SA, Williams JA
Am J Physiol Cell Physiol. 2010
PubMed ID: 19940064
Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells.
Chi AY, Waypa GB, Mungai PT, Schumacker PT
Antioxid Redox Signal. 2010
PubMed ID: 19747063
FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK.
Chorianopoulos E, Heger T, Lutz M, Frank D, Bea F, Katus HA, Frey N
Basic Res Cardiol. 2010
PubMed ID: 19629561
The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates.
Ogunjimi AA, Wiesner S, Briant DJ, Varelas X, Sicheri F, Forman-Kay J, Wrana JL
J Biol Chem. 2010
PubMed ID: 20026602
Vang-like protein 2 and Rac1 interact to regulate adherens junctions.
Lindqvist M, Horn Z, Bryja V, Schulte G, Papachristou P, Ajima R, Dyberg C, Arenas E, Yamaguchi TP, Lagercrantz H, Ringstedt T
J Cell Sci. 2010
PubMed ID: 20067994
Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA.
Broughton BR, Jernigan NL, Norton CE, Walker BR, Resta TC
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 19897743
Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells.
Chiba Y, Todoroki M, Misawa M
Pharmacol Res. 2010
PubMed ID: 19857574
Activation of RhoA and FAK induces ERK-mediated osteopontin expression in mechanical force-subjected periodontal ligament fibroblasts.
Hong SY, Jeon YM, Lee HJ, Kim JG, Baek JA, Lee JC
Mol Cell Biochem. 2010
PubMed ID: 19798549
m-Calpain antagonizes RhoA overactivation and endothelial barrier dysfunction under disturbed shear conditions.
Miyazaki T, Honda K, Ohata H
Cardiovasc Res. 2010
PubMed ID: 19752040
Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture.
Duan L, Chen G, Virmani S, Ying G, Raja SM, Chung BM, Rainey MA, Dimri M, Ortega-Cava CF, Zhao X, Clubb RJ, Tu C, Reddi AL, Naramura M, Band V, Band H
J Biol Chem. 2010
PubMed ID: 19826000
Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway.
Hirose A, Tanikawa T, Mori H, Okada Y, Tanaka Y
FEBS Lett. 2010
PubMed ID: 19944695
RhoA regulates peroxisome association to microtubules and the actin cytoskeleton.
Schollenberger L, Gronemeyer T, Huber CM, Lay D, Wiese S, Meyer HE, Warscheid B, Saffrich R, Peränen J, Gorgas K, Just WW
PLoS One. 2010
PubMed ID: 21079737
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Induction of RhoA gene expression by interleukin-4 in cultured human bronchial smooth muscle cells.
Chiba Y, Goto K, Momata M, Kobayashi T, Misawa M
J Smooth Muscle Res. 2010
PubMed ID: 20859068
A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer.
Tang YA, Wen WL, Chang JW, Wei TT, Tan YH, Salunke S, Chen CT, Chen CS, Wang YC
PLoS One. 2010
PubMed ID: 20856855
Silencing of RhoA and RhoC expression by RNA interference suppresses human colorectal carcinoma growth in vivo.
Wang H, Zhao G, Liu X, Sui A, Yang K, Yao R, Wang Z, Shi Q
J Exp Clin Cancer Res. 2010
PubMed ID: 20828398
The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.
Goh LL, Manser E
PLoS One. 2010
PubMed ID: 20811643
Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.
Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF
PLoS Biol. 2010
PubMed ID: 20808760
Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation.
Cheng HL, Su SJ, Huang LW, Hsieh BS, Hu YC, Hung TC, Chang KL
Mol Cancer. 2010
PubMed ID: 20507639
Vascular endothelial growth factor C promotes cervical cancer metastasis via up-regulation and activation of RhoA/ROCK-2/moesin cascade.
He M, Cheng Y, Li W, Liu Q, Liu J, Huang J, Fu X
BMC Cancer. 2010
PubMed ID: 20429915
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
Marshall AK, Barrett OP, Cullingford TE, Shanmugasundram A, Sugden PH, Clerk A
PLoS One. 2010
PubMed ID: 20368814
RHOA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones.
Della Peruta M, Giagulli C, Laudanna C, Scarpa A, Sorio C
Mol Cancer. 2010
PubMed ID: 20236512
Role of the RhoA/Rho-kinase pathway in the regulation of pulmonary vasoconstrictor function.
Nossaman BD, Nossaman VE, Murthy SN, Kadowitz PJ
Can J Physiol Pharmacol. 2010
PubMed ID: 20130732
Cyclic nucleotides converge on brown adipose tissue differentiation.
Amieux PS, McKnight GS
Sci Signal. 2010
PubMed ID: 20068229
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Huesa G, Baltrons MA, Gómez-Ramos P, Morán A, García A, Hidalgo J, Francés S, Santpere G, Ferrer I, Galea E
J Alzheimers Dis. 2010
PubMed ID: 20061625
Over expression of RhoA is associated with progression in invasive breast duct carcinoma.
Ma L, Liu YP, Geng CZ, Wang XL, Wang YJ, Zhang XH
Breast J. 2010
PubMed ID: 19912238
Mutation of ARHGAP9 in patients with coronary spastic angina.
Takefuji M, Asano H, Mori K, Amano M, Kato K, Watanabe T, Morita Y, Katsumi A, Itoh T, Takenawa T, Hirashiki A, Izawa H, Nagata K, Hirayama H, Takatsu F, Naoe T, Yokota M, Kaibuchi K
J Hum Genet. 2010
PubMed ID: 19911011
Involvement of aquaporin in thromboxane A2 receptor-mediated, G 12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells.
Saito M, Tanaka H, Sasaki M, Kurose H, Nakahata N
Cell Signal. 2010
PubMed ID: 19772916
Mechanical stretch-induced RhoA activation is mediated by the RhoGEF Vav2 in mesangial cells.
Peng F, Zhang B, Ingram AJ, Gao B, Zhang Y, Krepinsky JC
Cell Signal. 2010
PubMed ID: 19755152
The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.
Bristow JM, Sellers MH, Majumdar D, Anderson B, Hu L, Webb DJ
J Cell Sci. 2009
PubMed ID: 19934221
[PI3-kinase mediates activity of RhoA and interaction of RhoA with mDia1 in thrombin-induced platelet aggregation].
Gao GX, Dong HJ, Gu HT, Gao Y, Pan YZ, Yang Y, Chen XQ
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009
PubMed ID: 20030946
Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.
Swiercz JM, Worzfeld T, Offermanns S
Mol Cell Biol. 2009
PubMed ID: 19805522
Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.
Hunter JC, Zeidan A, Javadov S, Kilić A, Rajapurohitam V, Karmazyn M
J Mol Cell Cardiol. 2009
PubMed ID: 19799911
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK-dependent mechanism.
Benoit YD, Lussier C, Ducharme PA, Sivret S, Schnapp LM, Basora N, Beaulieu JF
Biol Cell. 2009
PubMed ID: 19527220
Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.
Bhavsar PJ, Vigorito E, Turner M, Ridley AJ
Exp Cell Res. 2009
PubMed ID: 19715691
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T
Int J Mol Med. 2009
PubMed ID: 19787194
Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.
Ponsioen B, van Zeijl L, Langeslag M, Berryman M, Littler D, Jalink K, Moolenaar WH
Mol Biol Cell. 2009
PubMed ID: 19776349
Cyclic GMP kinase and RhoA Ser188 phosphorylation integrate pro- and antifibrotic signals in blood vessels.
Sawada N, Itoh H, Miyashita K, Tsujimoto H, Sone M, Yamahara K, Arany ZP, Hofmann F, Nakao K
Mol Cell Biol. 2009
PubMed ID: 19737918
Angiotensin II induces RhoA activation through SHP2-dependent dephosphorylation of the RhoGAP p190A in vascular smooth muscle cells.
Bregeon J, Loirand G, Pacaud P, Rolli-Derkinderen M
Am J Physiol Cell Physiol. 2009
PubMed ID: 19692654
RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA.
Kun X, Lefeng W, Rongjing D, Xincun Y
J Card Surg. 2009
PubMed ID: 19682162
Rho GTPase activity modulates Wnt3a/beta-catenin signaling.
Rossol-Allison J, Stemmle LN, Swenson-Fields KI, Kelly P, Fields PE, McCall SJ, Casey PJ, Fields TA
Cell Signal. 2009
PubMed ID: 19482078
A novel function of heparan sulfate in the regulation of cell-cell fusion.
O'Donnell CD, Shukla D
J Biol Chem. 2009
PubMed ID: 19726670
Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding.
Goldyn AM, Rioja BA, Spatz JP, Ballestrem C, Kemkemer R
J Cell Sci. 2009
PubMed ID: 19812308
Down-regulation of miR-133a contributes to up-regulation of Rhoa in bronchial smooth muscle cells.
Chiba Y, Tanabe M, Goto K, Sakai H, Misawa M
Am J Respir Crit Care Med. 2009
PubMed ID: 19644046
Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
Cushman I, Casey PJ
J Biol Chem. 2009
PubMed ID: 19651782
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion.
Hoshino D, Tomari T, Nagano M, Koshikawa N, Seiki M
J Biol Chem. 2009
PubMed ID: 19654316
Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes.
Has C, Herz C, Zimina E, Qu HY, He Y, Zhang ZG, Wen TT, Gache Y, Aumailley M, Bruckner-Tuderman L
Am J Pathol. 2009
PubMed ID: 19762715
PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.
Ying Z, Giachini FR, Tostes RC, Webb RC
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19759375
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA.
Avalos AM, Valdivia AD, Muñoz N, Herrera-Molina R, Tapia JC, Lavandero S, Chiong M, Burridge K, Schneider P, Quest AF, Leyton L
J Cell Sci. 2009
PubMed ID: 19723805
Celiac disease IgA modulates vascular permeability in vitro through the activity of transglutaminase 2 and RhoA.
Myrsky E, Caja S, Simon-Vecsei Z, Korponay-Szabo IR, Nadalutti C, Collighan R, Mongeot A, Griffin M, Mäki M, Kaukinen K, Lindfors K
Cell Mol Life Sci. 2009
PubMed ID: 19680746
Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice.
Nuno DW, Harrod JS, Lamping KG
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19666843
Specific induction of migration and invasion of pancreatic carcinoma cells by RhoC, which differs from RhoA in its localisation and activity.
Dietrich KA, Schwarz R, Liska M, Grass S, Menke A, Meister M, Kierschke G, Längle C, Genze F, Giehl K
Biol Chem. 2009
PubMed ID: 19642867
Actin dynamics and Rho GTPases regulate the size and formation of parasitophorous vacuoles containing Coxiella burnetii.
Aguilera M, Salinas R, Rosales E, Carminati S, Colombo MI, Berón W
Infect Immun. 2009
PubMed ID: 19635823
A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme.
Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG
Mol Cell Proteomics. 2009
PubMed ID: 19620624
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Sugimoto K, Ishibashi T, Sawamura T, Inoue N, Kamioka M, Uekita H, Ohkawara H, Sakamoto T, Sakamoto N, Okamoto Y, Takuwa Y, Kakino A, Fujita Y, Tanaka T, Teramoto T, Maruyama Y, Takeishi Y
Cardiovasc Res. 2009
PubMed ID: 19487339
Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells.
Hutchison N, Hendry BM, Sharpe CC
Cell Signal. 2009
PubMed ID: 19477269
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding M, Peng HB, Shao F
Mol Cell. 2009
PubMed ID: 19782033
Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
Ye Y, Hu SJ, Li L
FEBS Lett. 2009
PubMed ID: 19716825
Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells.
Miyata M, Rikitake Y, Takahashi M, Nagamatsu Y, Yamauchi Y, Ogita H, Hirata K, Takai Y
J Biol Chem. 2009
PubMed ID: 19589776
Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity.
Carr HS, Cai C, Keinänen K, Frost JA
J Biol Chem. 2009
PubMed ID: 19586902
Coordination of Rho GTPase activities during cell protrusion.
Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G
Nature. 2009
PubMed ID: 19693013
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.
Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM
Mol Biol Cell. 2009
PubMed ID: 19625450
The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
Ford-Speelman DL, Roche JA, Bowman AL, Bloch RJ
Mol Biol Cell. 2009
PubMed ID: 19605563
N-cadherin/p120 catenin association at cell-cell contacts occurs in cholesterol-rich membrane domains and is required for RhoA activation and myogenesis.
Taulet N, Comunale F, Favard C, Charrasse S, Bodin S, Gauthier-Rouvière C
J Biol Chem. 2009
PubMed ID: 19546217
KiSS1 suppresses TNFalpha-induced breast cancer cell invasion via an inhibition of RhoA-mediated NF-kappaB activation.
Cho SG, Li D, Stafford LJ, Luo J, Rodriguez-Villanueva M, Wang Y, Liu M
J Cell Biochem. 2009
PubMed ID: 19533666
Tumor necrosis factor-alpha (TNF-alpha) induces upregulation of RhoA via NF-kappaB activation in cultured human bronchial smooth muscle cells.
Goto K, Chiba Y, Sakai H, Misawa M
J Pharmacol Sci. 2009
PubMed ID: 19602845
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.
Wu X, Guo R, Chen P, Wang Q, Cunningham PN
Am J Physiol Renal Physiol. 2009
PubMed ID: 19420112
Extracellular matrix controls insulin signaling in mammary epithelial cells through the RhoA/Rok pathway.
Lee YJ, Hsu TC, Du JY, Valentijn AJ, Wu TY, Cheng CF, Yang Z, Streuli CH
J Cell Physiol. 2009
PubMed ID: 19391109
Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27.
Garcia MC, Ray DM, Lackford B, Rubino M, Olden K, Roberts JD
J Biol Chem. 2009
PubMed ID: 19506078
RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.
Azab AK, Azab F, Blotta S, Pitsillides CM, Thompson B, Runnels JM, Roccaro AM, Ngo HT, Melhem MR, Sacco A, Jia X, Anderson KC, Lin CP, Rollins BJ, Ghobrial IM
Blood. 2009
PubMed ID: 19443661
Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation.
Khelfaoui M, Pavlowsky A, Powell AD, Valnegri P, Cheong KW, Blandin Y, Passafaro M, Jefferys JG, Chelly J, Billuart P
Hum Mol Genet. 2009
PubMed ID: 19401298
RhoA leads to up-regulation and relocalization of utrophin in muscle fibers.
Gauthier-Rouvière C, Bonet-Kerrache A
Biochem Biophys Res Commun. 2009
PubMed ID: 19409875
Patterns of Nogo-A, NgR, and RhoA expression in the brain tissues of rats with focal cerebral infarction.
Jiang W, Xia F, Han J, Wang J
Transl Res. 2009
PubMed ID: 19524873
Tetraspanin CD151 regulates RhoA activation and the dynamic stability of carcinoma cell-cell contacts.
Johnson JL, Winterwood N, DeMali KA, Stipp CS
J Cell Sci. 2009
PubMed ID: 19509057
NADPH oxidase 1 controls the persistence of directed cell migration by a Rho-dependent switch of alpha2/alpha3 integrins.
Sadok A, Pierres A, Dahan L, Prévôt C, Lehmann M, Kovacic H
Mol Cell Biol. 2009
PubMed ID: 19451223
Regulation of cellular contractile force in response to mechanical stretch by diphosphorylation of myosin regulatory light chain via RhoA signaling cascade.
Mizutani T, Kawabata K, Koyama Y, Takahashi M, Haga H
Cell Motil Cytoskeleton. 2009
PubMed ID: 19444895
Rho GTPase signaling and PTH 3-34, but not PTH 1-34, maintain the actin cytoskeleton and antagonize bisphosphonate effects in mouse osteoblastic MC3T3-E1 cells.
Kazmers NH, Ma SA, Yoshida T, Stern PH
Bone. 2009
PubMed ID: 19361585
RhoA/Rho kinase signaling in the cumulus mediates extracellular matrix assembly.
Yodoi R, Tamba S, Morimoto K, Segi-Nishida E, Nishihara M, Ichikawa A, Narumiya S, Sugimoto Y
Endocrinology. 2009
PubMed ID: 19342461
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Larrea MD, Hong F, Wander SA, da Silva TG, Helfman D, Lannigan D, Smith JA, Slingerland JM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470470
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
Wu D, Asiedu M, Wei Q
Oncogene. 2009
PubMed ID: 19421144
Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Förster R, Alon R, Fraemohs L, Dreck K, Weber C, Lämmermann T, Sixt M, Kolanus W
Blood. 2009
PubMed ID: 19346499
Dual roles for RHOA/RHO-kinase in the regulated trafficking of a voltage-sensitive potassium channel.
Stirling L, Williams MR, Morielli AD
Mol Biol Cell. 2009
PubMed ID: 19403695
Overexpression of E-cadherin on melanoma cells inhibits chemokine-promoted invasion involving p190RhoGAP/p120ctn-dependent inactivation of RhoA.
Molina-Ortiz I, Bartolomé RA, Hernández-Varas P, Colo GP, Teixidó J
J Biol Chem. 2009
PubMed ID: 19293150
Cerebral cavernous malformation 2 protein promotes smad ubiquitin regulatory factor 1-mediated RhoA degradation in endothelial cells.
Crose LE, Hilder TL, Sciaky N, Johnson GL
J Biol Chem. 2009
PubMed ID: 19318350
[Correlation between expression of RhoA and Rho kinase in uterine smooth muscle and the onset of labor].
Gao J, Ding YL
Zhonghua Fu Chan Ke Za Zhi. 2009
PubMed ID: 19573309
Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development.
Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P
Dev Dyn. 2009
PubMed ID: 19334288
Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase.
Ying Z, Yue P, Xu X, Zhong M, Sun Q, Mikolaj M, Wang A, Brook RD, Chen LC, Rajagopalan S
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19286943
Essential role of Rac1 and Rac3 GTPases in neuronal development.
Corbetta S, Gualdoni S, Ciceri G, Monari M, Zuccaro E, Tybulewicz VL, de Curtis I
FASEB J. 2009
PubMed ID: 19126596
ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK.
Khatiwala CB, Kim PD, Peyton SR, Putnam AJ
J Bone Miner Res. 2009
PubMed ID: 19113908
The fic domain: regulation of cell signaling by adenylylation.
Worby CA, Mattoo S, Kruger RP, Corbeil LB, Koller A, Mendez JC, Zekarias B, Lazar C, Dixon JE
Mol Cell. 2009
PubMed ID: 19362538
Rab35 regulates neurite outgrowth and cell shape.
Chevallier J, Koop C, Srivastava A, Petrie RJ, Lamarche-Vane N, Presley JF
FEBS Lett. 2009
PubMed ID: 19289122
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.
Yamazaki D, Kurisu S, Takenawa T
Oncogene. 2009
PubMed ID: 19234490
RhoA regulates G1-S progression of gastric cancer cells by modulation of multiple INK4 family tumor suppressors.
Zhang S, Tang Q, Xu F, Xue Y, Zhen Z, Deng Y, Liu M, Chen J, Liu S, Qiu M, Liao Z, Li Z, Luo D, Shi F, Zheng Y, Bi F
Mol Cancer Res. 2009
PubMed ID: 19372585
Optimisation of siRNA-mediated RhoA silencing in neuronal cultures.
Suggate EL, Ahmed Z, Read ML, Eaton-Charnock K, Douglas MR, Gonzalez AM, Berry M, Logan A
Mol Cell Neurosci. 2009
PubMed ID: 19340932
Ornithine decarboxylase regulates the activity and localization of rhoA via polyamination.
Mäkitie LT, Kanerva K, Andersson LC
Exp Cell Res. 2009
PubMed ID: 19331812
The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases.
Babbin BA, Sasaki M, Gerner-Schmidt KW, Nusrat A, Klapproth JM
Am J Pathol. 2009
PubMed ID: 19286565
The small GTPase RhoA is crucial for MC3T3-E1 osteoblastic cell survival.
Yoshida T, Clark MF, Stern PH
J Cell Biochem. 2009
PubMed ID: 19184980
Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1.
Mahoney CM, Morgan MR, Harrison A, Humphries MJ, Bass MD
J Biol Chem. 2009
PubMed ID: 19147498
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.
Brozzi F, Arcuri C, Giambanco I, Donato R
J Biol Chem. 2009
PubMed ID: 19147496
p120Ras-GAP binds the DLC1 Rho-GAP tumor suppressor protein and inhibits its RhoA GTPase and growth-suppressing activities.
Yang XY, Guan M, Vigil D, Der CJ, Lowy DR, Popescu NC
Oncogene. 2009
PubMed ID: 19151751
RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B.
Manukyan M, Nalbant P, Luxen S, Hahn KM, Knaus UG
J Immunol. 2009
PubMed ID: 19265130
A novel amplification target, ARHGAP5, promotes cell spreading and migration by negatively regulating RhoA in Huh-7 hepatocellular carcinoma cells.
Gen Y, Yasui K, Zen K, Nakajima T, Tsuji K, Endo M, Mitsuyoshi H, Minami M, Itoh Y, Tanaka S, Taniwaki M, Arii S, Okanoue T, Yoshikawa T
Cancer Lett. 2009
PubMed ID: 18996642
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1.
Cowell CF, Yan IK, Eiseler T, Leightner AC, Döppler H, Storz P
J Cell Biochem. 2009
PubMed ID: 19173301
Cytokine-induced F-actin reorganization in endothelial cells involves RhoA activation.
Campos SB, Ashworth SL, Wean S, Hosford M, Sandoval RM, Hallett MA, Atkinson SJ, Molitoris BA
Am J Physiol Renal Physiol. 2009
PubMed ID: 19144696
Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism.
Guo M, Daines D, Tang J, Shen Q, Perrin RM, Takada Y, Yuan SY, Wu MH
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19122172
RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets.
Jin J, Mao Y, Thomas D, Kim S, Daniel JL, Kunapuli SP
Biochem Pharmacol. 2009
PubMed ID: 19073150
Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.
Mori K, Amano M, Takefuji M, Kato K, Morita Y, Nishioka T, Matsuura Y, Murohara T, Kaibuchi K
J Biol Chem. 2009
PubMed ID: 19103606
SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells.
Ocana-Morgner C, Wahren C, Jessberger R
Blood. 2009
PubMed ID: 18802007
RhoA induces expression of inflammatory cytokine in adipocytes.
Nakayama Y, Komuro R, Yamamoto A, Miyata Y, Tanaka M, Matsuda M, Fukuhara A, Shimomura I
Biochem Biophys Res Commun. 2009
PubMed ID: 19101507
Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines.
Ma L, Liu YP, Zhang XH, Xing LX, Wang JL, Geng CZ
Chin J Cancer. 2009
PubMed ID: 19550117
Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation.
Kim WY, Gonsiorek EA, Barnhart C, Davare MA, Engebose AJ, Lauridsen H, Bruun D, Lesiak A, Wayman G, Bucelli R, Higgins D, Lein PJ
J Neurochem. 2009
PubMed ID: 19209406
PRL-3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up-regulating the levels and activities of Rho-A/C in lung cancer.
Ming J, Liu N, Gu Y, Qiu X, Wang EH
Pathology. 2009
PubMed ID: 19152186
Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.
Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, Slaugenhaupt SA
Mol Cell Biol. 2009
PubMed ID: 19015235
DLC1 tumor suppressor gene inhibits migration and invasion of multiple myeloma cells through RhoA GTPase pathway.
Ullmannova-Benson V, Guan M, Zhou X, Tripathi V, Yang XY, Zimonjic DB, Popescu NC
Leukemia. 2009
PubMed ID: 18923442
Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells.
Kim TJ, Seong J, Ouyang M, Sun J, Lu S, Hong JP, Wang N, Wang Y
J Cell Physiol. 2009
PubMed ID: 18844232
Interleukin-13 augments bronchial smooth muscle contractility with an up-regulation of RhoA protein.
Chiba Y, Nakazawa S, Todoroki M, Shinozaki K, Sakai H, Misawa M
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18688040
Differential activation of Rac1 and RhoA in neuroblastoma cell fractions.
Seifert JL, Som S, Hynds DL
Neurosci Lett. 2009
PubMed ID: 19027829
Overexpression of RhoA induces preneoplastic transformation of primary mammary epithelial cells.
Zhao X, Lu L, Pokhriyal N, Ma H, Duan L, Lin S, Jafari N, Band H, Band V
Cancer Res. 2009
PubMed ID: 19147561
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
Yarbrough ML, Li Y, Kinch LN, Grishin NV, Ball HL, Orth K
Science. 2009
PubMed ID: 19039103
F11-mediated inhibition of RhoA signalling enhances the spread of vaccinia virus in vitro and in vivo in an intranasal mouse model of infection.
Cordeiro JV, Guerra S, Arakawa Y, Dodding MP, Esteban M, Way M
PLoS One. 2009
PubMed ID: 20041165
Direct activation of RhoA by reactive oxygen species requires a redox-sensitive motif.
Aghajanian A, Wittchen ES, Campbell SL, Burridge K
PLoS One. 2009
PubMed ID: 19956681
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Aoki T, Ueda S, Kataoka T, Satoh T
BMC Cell Biol. 2009
PubMed ID: 19635168
Expression of RhoA and RhoC in colorectal carcinoma and its relations with clinicopathological parameters.
Wang HB, Liu XP, Liang J, Yang K, Sui AH, Liu YJ
Clin Chem Lab Med. 2009
PubMed ID: 19499974
Arylsulfatase B regulates colonic epithelial cell migration by effects on MMP9 expression and RhoA activation.
Bhattacharyya S, Tobacman JK
Clin Exp Metastasis. 2009
PubMed ID: 19306108
Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node.
Mahtab EA, Vicente-Steijn R, Hahurij ND, Jongbloed MR, Wisse LJ, DeRuiter MC, Uhrin P, Zaujec J, Binder BR, Schalij MJ, Poelmann RE, Gittenberger-de Groot AC
Dev Dyn. 2009
PubMed ID: 19097191
RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.
Malaval C, Laffargue M, Barbaras R, Rolland C, Peres C, Champagne E, Perret B, Tercé F, Collet X, Martinez LO
Cell Signal. 2009
PubMed ID: 18948190
Dissecting the thermodynamics of GAP-RhoA interactions.
Jelen F, Lachowicz P, Apostoluk W, Mateja A, Derewenda ZS, Otlewski J
J Struct Biol. 2009
PubMed ID: 18929667
The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L
Blood. 2009
PubMed ID: 18824598
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.
Henstridge CM, Balenga NA, Ford LA, Ross RA, Waldhoer M, Irving AJ
FASEB J. 2009
PubMed ID: 18757503
Probing the recognition properties of the antiparallel coiled coil motif from PKN by protein grafting.
Li Y, Kaur H, Oakley MG
Biochemistry. 2008
PubMed ID: 19049388
Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection.
Del Re DP, Miyamoto S, Brown JH
J Biol Chem. 2008
PubMed ID: 18854312
Specificity of interactions between mDia isoforms and Rho proteins.
Lammers M, Meyer S, Kühlmann D, Wittinghofer A
J Biol Chem. 2008
PubMed ID: 18829452
Roles of RhoA and Rac1 on actin remodeling and cell alignment and differentiation in fetal type II epithelial cells exposed to cyclic mechanical stretch.
Silbert O, Wang Y, Maciejewski BS, Lee HS, Shaw SK, Sanchez-Esteban J
Exp Lung Res. 2008
PubMed ID: 19085564
Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer.
Horiuchi A, Kikuchi N, Osada R, Wang C, Hayashi A, Nikaido T, Konishi I
Cancer Sci. 2008
PubMed ID: 19038009
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.
Liu N, Bezprozvannaya S, Williams AH, Qi X, Richardson JA, Bassel-Duby R, Olson EN
Genes Dev. 2008
PubMed ID: 19015276
Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
Orimo T, Ojima H, Hiraoka N, Saito S, Kosuge T, Kakisaka T, Yokoo H, Nakanishi K, Kamiyama T, Todo S, Hirohashi S, Kondo T
Hepatology. 2008
PubMed ID: 18937283
Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.
Chen Y, Stump RJ, Lovicu FJ, Shimono A, McAvoy JW
Dev Biol. 2008
PubMed ID: 18824165
RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.
Ordóñez-Morán P, Larriba MJ, Pálmer HG, Valero RA, Barbáchano A, Duñach M, de Herreros AG, Villalobos C, Berciano MT, Lafarga M, Muñoz A
J Cell Biol. 2008
PubMed ID: 19015318
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.
Lim WG, Chen X, Liu JP, Tan BJ, Zhou S, Smith A, Lees N, Hou L, Gu F, Yu XY, Du Y, Smith D, Verma C, Liu K, Duan W
Arch Biochem Biophys. 2008
PubMed ID: 18835241
Structure and function of Salmonella SifA indicate that its interactions with SKIP, SseJ, and RhoA family GTPases induce endosomal tubulation.
Ohlson MB, Huang Z, Alto NM, Blanc MP, Dixon JE, Chai J, Miller SI
Cell Host Microbe. 2008
PubMed ID: 18996344
AMF/PGI transactivates the MMP-3 gene through the activation of Src-RhoA-phosphatidylinositol 3-kinase signaling to induce hepatoma cell migration.
Shih WL, Liao MH, Yu FL, Lin PY, Hsu HY, Chiu SJ
Cancer Lett. 2008
PubMed ID: 18571835
Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion.
Fromigué O, Hamidouche Z, Marie PJ
J Biol Chem. 2008
PubMed ID: 18757369
RhoA GTPase and F-actin dynamically regulate the permeability of Cx43-made channels in rat cardiac myocytes.
Derangeon M, Bourmeyster N, Plaisance I, Pinet-Charvet C, Chen Q, Duthe F, Popoff MR, Sarrouilhe D, Hervé JC
J Biol Chem. 2008
PubMed ID: 18667438
Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells.
Zaoui K, Honoré S, Isnardon D, Braguer D, Badache A
J Cell Biol. 2008
PubMed ID: 18955552
MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA.
Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ
Mol Cell Biol. 2008
PubMed ID: 18794355
Staphylococcal enterotoxin B causes differential expression of Rnd3 and RhoA in renal proximal tubule epithelial cells while inducing actin stress fiber assembly and apoptosis.
Ionin B, Hammamieh R, Shupp JW, Das R, Pontzer CH, Jett M
Microb Pathog. 2008
PubMed ID: 18721871
Thrombin receptor and RhoA mediate cell proliferation through integrins and cysteine-rich protein 61.
Walsh CT, Radeff-Huang J, Matteo R, Hsiao A, Subramaniam S, Stupack D, Brown JH
FASEB J. 2008
PubMed ID: 18687805
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases.
Seifert JP, Zhou Y, Hicks SN, Sondek J, Harden TK
J Biol Chem. 2008
PubMed ID: 18765661
Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.
Gavard J, Gutkind JS
J Biol Chem. 2008
PubMed ID: 18713748
NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer.
Murray D, Horgan G, Macmathuna P, Doran P
Br J Cancer. 2008
PubMed ID: 18827818
Activated G(alpha)13 impairs cell invasiveness through p190RhoGAP-mediated inhibition of RhoA activity.
Bartolomé RA, Wright N, Molina-Ortiz I, Sánchez-Luque FJ, Teixidó J
Cancer Res. 2008
PubMed ID: 18922893
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling.
Kamanova J, Kofronova O, Masin J, Genth H, Vojtova J, Linhartova I, Benada O, Just I, Sebo P
J Immunol. 2008
PubMed ID: 18832717
Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.
Papadopoulou N, Charalampopoulos I, Alevizopoulos K, Gravanis A, Stournaras C
Exp Cell Res. 2008
PubMed ID: 18694745
MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.
Swenson-Fields KI, Sandquist JC, Rossol-Allison J, Blat IC, Wennerberg K, Burridge K, Means AR
Mol Cell. 2008
PubMed ID: 18851832
ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity.
Wu X, Kodama A, Fuchs E
Cell. 2008
PubMed ID: 18854161
ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.
Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M
J Biol Chem. 2008
PubMed ID: 18660502
[Effect of beta-elemene on the proliferation, migration and RhoA expression of hepatic stellate cells induced by angiotensin II]
Yang L, Zhu QJ, Zhou W, Ye J, Qian W, Zhu R, Hu TH, Hou XH
Zhonghua Gan Zang Bing Za Zhi. 2008
PubMed ID: 18983771
Therapeutic IMC-C225 antibody inhibits breast cancer cell invasiveness via Vav2-dependent activation of RhoA GTPase.
Molli PR, Adam L, Kumar R
Clin Cancer Res. 2008
PubMed ID: 18829495
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.
Sims SM, Chrones T, Preiksaitis HG
J Pharmacol Exp Ther. 2008
PubMed ID: 18628484
Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK.
Sun Q, Yue P, Ying Z, Cardounel AJ, Brook RD, Devlin R, Hwang JS, Zweier JL, Chen LC, Rajagopalan S
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18599801
WNK2 modulates MEK1 activity through the Rho GTPase pathway.
Moniz S, Matos P, Jordan P
Cell Signal. 2008
PubMed ID: 18593598
The role of Kalirin9 in p75/nogo receptor-mediated RhoA activation in cerebellar granule neurons.
Harrington AW, Li QM, Tep C, Park JB, He Z, Yoon SO
J Biol Chem. 2008
PubMed ID: 18625710
Inadequate activation of the GTPase RhoA contributes to the lack of fibronectin matrix assembly in von Hippel-Lindau protein-defective renal cancer cells.
Feijóo-Cuaresma M, Méndez F, Maqueda A, Esteban MA, Naranjo-Suarez S, Castellanos MC, del Cerro MH, Vazquez SN, García-Pardo A, Landázuri MO, Calzada MJ
J Biol Chem. 2008
PubMed ID: 18567581
Neurogenin 2 controls cortical neuron migration through regulation of Rnd2.
Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F
Nature. 2008
PubMed ID: 18690213
Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1.
Moore SW, Correia JP, Lai Wing Sun K, Pool M, Fournier AE, Kennedy TE
Development. 2008
PubMed ID: 18653556
Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia.
Jernigan NL, Walker BR, Resta TC
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18621909
Cdc42 and RhoA have opposing roles in regulating membrane type 1-matrix metalloproteinase localization and matrix metalloproteinase-2 activation.
Ispanovic E, Serio D, Haas TL
Am J Physiol Cell Physiol. 2008
PubMed ID: 18562481
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
Nojima H, Adachi M, Matsui T, Okawa K, Tsukita S, Tsukita S
Nat Cell Biol. 2008
PubMed ID: 18604197
Marked effect of RhoA-specific shRNA-producing plasmids on neurite growth in PC12 cells.
Fan YM, Pang CP, Harvey AR, Cui Q
Neurosci Lett. 2008
PubMed ID: 18556119
Activated RHOA and peripheral axon regeneration.
Cheng C, Webber CA, Wang J, Xu Y, Martinez JA, Liu WQ, McDonald D, Guo GF, Nguyen MD, Zochodne DW
Exp Neurol. 2008
PubMed ID: 18554585
RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha.
Ho TT, Merajver SD, Lapière CM, Nusgens BV, Deroanne CF
J Biol Chem. 2008
PubMed ID: 18524772
The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation.
Mohseni M, Chishti AH
Mol Cell Biol. 2008
PubMed ID: 18505823
Rho plays a key role in TGF-beta1-induced cytoskeletal rearrangement in human retinal pigment epithelium.
Lee J, Ko M, Joo CK
J Cell Physiol. 2008
PubMed ID: 18314880
Rho/Rho-associated kinase signal regulates myogenic differentiation via myocardin-related transcription factor-A/Smad-dependent transcription of the Id3 gene.
Iwasaki K, Hayashi K, Fujioka T, Sobue K
J Biol Chem. 2008
PubMed ID: 18477564
Pulsatile equibiaxial stretch inhibits thrombin-induced RhoA and NF-kappaB activation.
Haga JH, Kaunas R, Radeff-Huang J, Weems JM, Estrada KD, Chien S, Brown JH, Seasholtz TM
Biochem Biophys Res Commun. 2008
PubMed ID: 18474218
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
Down-regulated expression of RhoA in human conventional renal cell carcinoma.
Pu YS, Wang CW, Liu GY, Kuo YZ, Huang CY, Kang WY, Shun CT, Lin CC, Wu WJ, Hour TC
Anticancer Res. 2008
PubMed ID: 18751372
RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease.
Bellizzi A, Mangia A, Chiriatti A, Petroni S, Quaranta M, Schittulli F, Malfettone A, Cardone RA, Paradiso A, Reshkin SJ
Int J Mol Med. 2008
PubMed ID: 18575772
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Dittert DD, Kielisch C, Alldinger I, Zietz C, Meyer W, Dobrowolski F, Saeger HD, Baretton GB
Hum Pathol. 2008
PubMed ID: 18495213
Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone.
Homma N, Nagaoka T, Karoor V, Imamura M, Taraseviciene-Stewart L, Walker LA, Fagan KA, McMurtry IF, Oka M
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18469113
Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles.
Sakuma K, Akiho M, Nakashima H, Akima H, Yasuhara M
Biochim Biophys Acta. 2008
PubMed ID: 18442487
TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae.
Peng F, Zhang B, Wu D, Ingram AJ, Gao B, Krepinsky JC
Am J Physiol Renal Physiol. 2008
PubMed ID: 18434385
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Sakurai-Yageta M, Recchi C, Le Dez G, Sibarita JB, Daviet L, Camonis J, D'Souza-Schorey C, Chavrier P
J Cell Biol. 2008
PubMed ID: 18541705
The small peptide OGP(10-14) acts through Src kinases and RhoA pathways in Mo-7e cells: morphologic and immunologic evaluation.
Mattii L, Battolla B, Moscato S, Fazzi R, Galimberti S, Bernardini N, Dolfi A, Petrini M
Med Sci Monit. 2008
PubMed ID: 18509267
RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease.
Peng F, Wu D, Gao B, Ingram AJ, Zhang B, Chorneyko K, McKenzie R, Krepinsky JC
Diabetes. 2008
PubMed ID: 18356410
BNIP2 extra long inhibits RhoA and cellular transformation by Lbc RhoGEF via its BCH domain.
Soh UJ, Low BC
J Cell Sci. 2008
PubMed ID: 18445682
Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.
Kakinuma N, Roy BC, Zhu Y, Wang Y, Kiyama R
J Cell Biol. 2008
PubMed ID: 18458160
MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance.
Ogata T, Ueyama T, Isodono K, Tagawa M, Takehara N, Kawashima T, Harada K, Takahashi T, Shioi T, Matsubara H, Oh H
Mol Cell Biol. 2008
PubMed ID: 18332105
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA.
Chang YC, Nalbant P, Birkenfeld J, Chang ZF, Bokoch GM
Mol Biol Cell. 2008
PubMed ID: 18287519
Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF
Black SA, Trackman PC
J Biol Chem. 2008
PubMed ID: 18287089
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM
Exp Cell Res. 2008
PubMed ID: 18316075
Hindlimb unweighting induces changes in the RhoA-Rho-kinase pathway of the rat abdominal aorta.
Summers SM, Nguyen SV, Purdy RE
Vascul Pharmacol. 2008
PubMed ID: 18457998
Glucocorticoids ameliorate antigen-induced bronchial smooth muscle hyperresponsiveness by inhibiting upregulation of RhoA in rats.
Chiba Y, Goto K, Hirahara M, Sakai H, Misawa M
J Pharmacol Sci. 2008
PubMed ID: 18391481
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity.
Zhou S, Bachem MG, Seufferlein T, Li Y, Gross HJ, Schmelz A
Cell Signal. 2008
PubMed ID: 18207700
Lesional accumulation of RhoA(+) cells in brains of experimental autoimmune encephalomyelitis and multiple sclerosis.
Zhang Z, Schittenhelm J, Meyermann R, Schluesener HJ
Neuropathol Appl Neurobiol. 2008
PubMed ID: 17983427
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways.
Kontaridis MI, Yang W, Bence KK, Cullen D, Wang B, Bodyak N, Ke Q, Hinek A, Kang PM, Liao R, Neel BG
Circulation. 2008
PubMed ID: 18316486
RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.
Garnacho C, Shuvaev V, Thomas A, McKenna L, Sun J, Koval M, Albelda S, Muzykantov V, Muro S
Blood. 2008
PubMed ID: 18182571
Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells.
Nishimoto-Hazuku A, Hirase T, Ide N, Ikeda Y, Node K
J Cardiovasc Pharmacol. 2008
PubMed ID: 18356691
TGFBR1*6A enhances the migration and invasion of MCF-7 breast cancer cells through RhoA activation.
Rosman DS, Phukan S, Huang CC, Pasche B
Cancer Res. 2008
PubMed ID: 18316594
RhoA is involved in LFA-1 extension triggered by CXCL12 but not in a novel outside-in LFA-1 activation facilitated by CXCL9.
Pasvolsky R, Grabovsky V, Giagulli C, Shulman Z, Shamri R, Feigelson SW, Laudanna C, Alon R
J Immunol. 2008
PubMed ID: 18292502
Transcriptome and proteome analysis of early embryonic mouse brain development.
Hartl D, Irmler M, Römer I, Mader MT, Mao L, Zabel C, de Angelis MH, Beckers J, Klose J
Proteomics. 2008
PubMed ID: 18283662
Alpha2-adrenoceptors enhance angiotensin II-induced renal vasoconstriction: role for NADPH oxidase and RhoA.
Jackson EK, Gillespie DG, Zhu C, Ren J, Zacharia LC, Mi Z
Hypertension. 2008
PubMed ID: 18250367
Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control.
Kolavennu V, Zeng L, Peng H, Wang Y, Danesh FR
Diabetes. 2008
PubMed ID: 18083785
Roles of Rho guanosine 5'-triphosphatase A, Rho kinases, and extracellular signal regulated kinase (1/2) in prostaglandin E2-mediated migration of first-trimester human extravillous trophoblast.
Nicola C, Chirpac A, Lala PK, Chakraborty C
Endocrinology. 2008
PubMed ID: 18079197
Dexamethasone suppresses infiltration of RhoA+ cells into early lesions of rat traumatic brain injury.
Zhang Z, Fauser U, Schluesener HJ
Acta Neuropathol. 2008
PubMed ID: 17929039
Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.
Riddick N, Ohtani K, Surks HK
J Cell Biochem. 2008
PubMed ID: 17661354
Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901.
Tao Y, Chen YC, Li YY, Yang SQ, Xu WR
World J Gastroenterol. 2008
PubMed ID: 18300342
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Malchinkhuu E, Sato K, Maehama T, Mogi C, Tomura H, Ishiuchi S, Yoshimoto Y, Kurose H, Okajima F
Biochem Biophys Res Commun. 2008
PubMed ID: 18088600
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.
Xie Y, Tan EJ, Wee S, Manser E, Lim L, Koh CG
J Cell Sci. 2008
PubMed ID: 18230650
Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent.
Merdek KD, Jaffe AB, Dutt P, Olson MF, Hall A, Fanburg BL, Kayyali US, Toksoz D
Biochem Biophys Res Commun. 2008
PubMed ID: 18078809
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.
Fang WB, Ireton RC, Zhuang G, Takahashi T, Reynolds A, Chen J
J Cell Sci. 2008
PubMed ID: 18198190
N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway.
Zhao Y, Li J, Xing Y, Wang J, Lu C, Xin X, Geng M
Mol Cell Biochem. 2008
PubMed ID: 18060576
The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer.
Takami Y, Higashi M, Kumagai S, Kuo PC, Kawana H, Koda K, Miyazaki M, Harigaya K
Dig Dis Sci. 2008
PubMed ID: 17597401
G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
Bikkavilli RK, Feigin ME, Malbon CC
J Cell Sci. 2008
PubMed ID: 18187455
IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway.
Temporin K, Tanaka H, Kuroda Y, Okada K, Yachi K, Moritomo H, Murase T, Yoshikawa H
Biochem Biophys Res Commun. 2008
PubMed ID: 17996195
HPV16 E7-dependent transformation activates NHE1 through a PKA-RhoA-induced inhibition of p38alpha.
Cardone RA, Busco G, Greco MR, Bellizzi A, Accardi R, Cafarelli A, Monterisi S, Carratù P, Casavola V, Paradiso A, Tommasino M, Reshkin SJ
PLoS ONE. 2008
PubMed ID: 18953413
p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells.
Wang XQ, Lui EL, Cai Q, Ching WY, Liu KS, Poon RT, Fan ST
Tumour Biol. 2008
PubMed ID: 18781093
Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma.
Xiaorong L, Wei W, Liyuan Q, Kaiyan Y
BMC Cancer. 2008
PubMed ID: 18651974
A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage.
Guerra L, Carr HS, Richter-Dahlfors A, Masucci MG, Thelestam M, Frost JA, Frisan T
PLoS ONE. 2008
PubMed ID: 18509476
Regulation of phospholipase C-delta1 by ARGHAP6, a GTPase-activating protein for RhoA: possible role for enhanced activity of phospholipase C in hypertension.
Ochocka AM, Grden M, Sakowicz-Burkiewicz M, Szutowicz A, Pawelczyk T
Int J Biochem Cell Biol. 2008
PubMed ID: 18434237
Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell function.
Waiczies S, Bendix I, Zipp F
Sci Signal. 2008
PubMed ID: 18364514
[The Rho protein family and its role in the cellular cytoskeleton]
Nowak JM, Grzanka A, Zuryń A, Stepień A
Postepy Hig Med Dosw (Online). 2008
PubMed ID: 18334926
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Nie D, Guo Y, Yang D, Tang Y, Chen Y, Wang MT, Zacharek A, Qiao Y, Che M, Honn KV
Cancer Res. 2008
PubMed ID: 18172303
Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei.
Zeidan A, Javadov S, Chakrabarti S, Karmazyn M
Cardiovasc Res. 2008
PubMed ID: 18006472
MIP-2 causes differential activation of RhoA in mouse aortic versus pulmonary artery endothelial cells.
Moldobaeva A, Baek A, Wagner EM
Microvasc Res. 2008
PubMed ID: 17662312
START-GAP3/DLC3 is a GAP for RhoA and Cdc42 and is localized in focal adhesions regulating cell morphology.
Kawai K, Kiyota M, Seike J, Deki Y, Yagisawa H
Biochem Biophys Res Commun. 2007
PubMed ID: 17976533
Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs.
Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ
Science. 2007
PubMed ID: 18096806
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A
J Biol Chem. 2007
PubMed ID: 17947237
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation.
Homma N, Nagaoka T, Morio Y, Ota H, Gebb SA, Karoor V, McMurtry IF, Oka M
J Cardiovasc Pharmacol. 2007
PubMed ID: 18091588
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Sarrabayrouse G, Synaeve C, Leveque K, Favre G, Tilkin-Mariamé AF
Neoplasia. 2007
PubMed ID: 18084615
Clinical and prognostic significance of RhoA and RhoC gene expression in esophageal squamous cell carcinoma.
Faried A, Faried LS, Usman N, Kato H, Kuwano H
Ann Surg Oncol. 2007
PubMed ID: 17896152
Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility.
Basile JR, Gavard J, Gutkind JS
J Biol Chem. 2007
PubMed ID: 17855350
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.
Dubash AD, Wennerberg K, García-Mata R, Menold MM, Arthur WT, Burridge K
J Cell Sci. 2007
PubMed ID: 17971419
Geranylgeranylation but not GTP loading determines rho migratory function in T cells.
Waiczies S, Bendix I, Prozorovski T, Ratner M, Nazarenko I, Pfueller CF, Brandt AU, Herz J, Brocke S, Ullrich O, Zipp F
J Immunol. 2007
PubMed ID: 17947676
Involvement of RhoA in progression of human hepatocellular carcinoma.
Wang D, Dou K, Xiang H, Song Z, Zhao Q, Chen Y, Li Y
J Gastroenterol Hepatol. 2007
PubMed ID: 17914970
Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling.
Schreibelt G, Kooij G, Reijerkerk A, van Doorn R, Gringhuis SI, van der Pol S, Weksler BB, Romero IA, Couraud PO, Piontek J, Blasig IE, Dijkstra CD, Ronken E, de Vries HE
FASEB J. 2007
PubMed ID: 17586731
Thyroid hormones reorganize the cytoskeleton of glial cells through Gfap phosphorylation and Rhoa-dependent mechanisms.
Zamoner A, Funchal C, Jacques-Silva MC, Gottfried C, Barreto Silva FR, Pessoa-Pureur R
Cell Mol Neurobiol. 2007
PubMed ID: 17334943
RhoA, encoding a Rho GTPase, is associated with smoking initiation.
Chen X, Che Y, Zhang L, Putman AH, Damaj I, Martin BR, Kendler KS, Miles MF
Genes Brain Behav. 2007
PubMed ID: 17284169
Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.
Zhang Y, Sawada T, Jing X, Yokote H, Yan X, Sakaguchi K
J Biol Chem. 2007
PubMed ID: 17702745
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Finlay GA, Malhowski AJ, Liu Y, Fanburg BL, Kwiatkowski DJ, Toksoz D
Cancer Res. 2007
PubMed ID: 17942919
Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity.
Tani M, Kawakami A, Nagai M, Shimokado K, Kondo K, Yoshida M
FEBS Lett. 2007
PubMed ID: 17825823
Oligodendrocyte lineage transcription factor 2 inhibits the motility of a human glial tumor cell line by activating RhoA.
Tabu K, Ohba Y, Suzuki T, Makino Y, Kimura T, Ohnishi A, Sakai M, Watanabe T, Tanaka S, Sawa H
Mol Cancer Res. 2007
PubMed ID: 17951409
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension.
Bhadriraju K, Yang M, Alom Ruiz S, Pirone D, Tan J, Chen CS
Exp Cell Res. 2007
PubMed ID: 17673200
Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation.
Tas PW, Gambaryan S, Roewer N
J Cell Biochem. 2007
PubMed ID: 17492663
Lens fiber cell elongation and differentiation is associated with a robust increase in myosin light chain phosphorylation in the developing mouse.
Maddala R, Skiba N, Vasantha Rao P
Differentiation. 2007
PubMed ID: 17459090
The RhoA transcriptional program in pre-T cells.
Mullin M, Lightfoot K, Clarke R, Miller M, Lahesmaa R, Cantrell D
FEBS Lett. 2007
PubMed ID: 17716670
GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability.
Knezevic N, Roy A, Timblin B, Konstantoulaki M, Sharma T, Malik AB, Mehta D
Mol Cell Biol. 2007
PubMed ID: 17636025
RhoA regulation of NF-kappaB activation is mediated by COX-2-dependent feedback inhibition of IKK in kidney epithelial cells.
Polk WW, Ellis ME, Kushleika JV, Simmonds PL, Woods JS
Am J Physiol Cell Physiol. 2007
PubMed ID: 17615156
Actin cytoskeleton dynamics promotes leptin-induced vascular smooth muscle hypertrophy via RhoA/ROCK- and phosphatidylinositol 3-kinase/protein kinase B-dependent pathways.
Zeidan A, Paylor B, Steinhoff KJ, Javadov S, Rajapurohitam V, Chakrabarti S, Karmazyn M
J Pharmacol Exp Ther. 2007
PubMed ID: 17562852
RhoA activation contributes to sex differences in vascular contractions.
Nuno DW, Korovkina VP, England SK, Lamping KG
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17556652
Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.
Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD
Cell. 2007
PubMed ID: 17719543
Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo.
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP
J Biol Chem. 2007
PubMed ID: 17562701
Inhibitory role of RhoA on senescence-like growth arrest by a mechanism involving modulation of phosphatase activity.
Park C, Lee I, Jang JH, Kang WK
FEBS Lett. 2007
PubMed ID: 17658517
RhoA regulates dendrite branching in hippocampal neurons by decreasing cypin protein levels.
Chen H, Firestein BL
J Neurosci. 2007
PubMed ID: 17670984
Polo-like kinase 1 regulates RhoA during cytokinesis exit in human cells.
Dai BN, Yang Y, Chau Z, Jhanwar-Uniyal M
Cell Prolif. 2007
PubMed ID: 17635521
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.
Hilgers RH, Todd J, Webb RC
J Hypertens. 2007
PubMed ID: 17620967
Lipid rafts of primary endothelial cells are essential for Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8-induced phosphatidylinositol 3-kinase and RhoA-GTPases critical for microtubule dynamics and nuclear delivery of viral DNA but dispensab
Raghu H, Sharma-Walia N, Veettil MV, Sadagopan S, Caballero A, Sivakumar R, Varga L, Bottero V, Chandran B
J Virol. 2007
PubMed ID: 17507466
Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells.
Helms WS, Jeffrey JL, Holmes DA, Townsend MB, Clipstone NA, Su L
J Leukoc Biol. 2007
PubMed ID: 17502338
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells.
Loberg RD, Tantivejkul K, Craig M, Neeley CK, Pienta KJ
J Cell Biochem. 2007
PubMed ID: 17492768
Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.
Barman SA
Am J Physiol Lung Cell Mol Physiol. 2007
PubMed ID: 17468135
Lysophosphatidic acid rescues RhoA activation and phosphoinositides levels in astrocytes exposed to ethanol.
Martínez SE, Lázaro-Diéguez F, Selva J, Calvo F, Piqueras JR, Crespo P, Claro E, Egea G
J Neurochem. 2007
PubMed ID: 17442046
Lysophosphatidic acid regulates trafficking of beta2-adrenergic receptors: the Galpha13/p115RhoGEF/JNK pathway stimulates receptor internalization.
Shumay E, Tao J, Wang HY, Malbon CC
J Biol Chem. 2007
PubMed ID: 17493936
The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.
Papakonstanti EA, Ridley AJ, Vanhaesebroeck B
EMBO J. 2007
PubMed ID: 17581634
RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs.
Gorovoy M, Neamu R, Niu J, Vogel S, Predescu D, Miyoshi J, Takai Y, Kini V, Mehta D, Malik AB, Voyno-Yasenetskaya T
Circ Res. 2007
PubMed ID: 17525371
Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices.
Gadea G, de Toledo M, Anguille C, Roux P
J Cell Biol. 2007
PubMed ID: 17606864
Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase.
Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, Nevens F, Sauerbruch T, Heller J
Hepatology. 2007
PubMed ID: 17596891
Regulation of T-type calcium channels by Rho-associated kinase.
Iftinca M, Hamid J, Chen L, Varela D, Tadayonnejad R, Altier C, Turner RW, Zamponi GW
Nat Neurosci. 2007
PubMed ID: 17558400
Rac1, RhoA, and Cdc42 participate in HeLa cell invasion by group B streptococcus.
Burnham CA, Shokoples SE, Tyrrell GJ
FEMS Microbiol Lett. 2007
PubMed ID: 17517067
Differential effects of phenylalanine on Rac1, Cdc42, and RhoA expression and activity in cultured cortical neurons.
Zhang Y, Zhang H, Yuan X, Gu X
Pediatr Res. 2007
PubMed ID: 17515837
Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury.
Zhang H, Cybulsky AV, Aoudjit L, Zhu J, Li H, Lamarche-Vane N, Takano T
Am J Physiol Renal Physiol. 2007
PubMed ID: 17376765
The functional consequence of RhoA knockdown by RNA interference in rat cerebral arteries.
Corteling RL, Brett SE, Yin H, Zheng XL, Walsh MP, Welsh DG
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17369454
The A-kinase anchoring protein (AKAP)-Lbc-signaling complex mediates alpha1 adrenergic receptor-induced cardiomyocyte hypertrophy.
Appert-Collin A, Cotecchia S, Nenniger-Tosato M, Pedrazzini T, Diviani D
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17537920
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Berto G, Camera P, Fusco C, Imarisio S, Ambrogio C, Chiarle R, Silengo L, Di Cunto F
J Cell Sci. 2007
PubMed ID: 17488780
Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration.
Su Z, Cao L, Zhu Y, Liu X, Huang Z, Huang A, He C
J Cell Sci. 2007
PubMed ID: 17488779
RhoA-mediated apical actin enrichment is required for ciliogenesis and promoted by Foxj1.
Pan J, You Y, Huang T, Brody SL
J Cell Sci. 2007
PubMed ID: 17488776
Synaptic scaffolding molecule alpha is a scaffold to mediate N-methyl-D-aspartate receptor-dependent RhoA activation in dendrites.
Iida J, Ishizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina N, Ohashi K, Mizuno K, Tsutsumi T, Mizoguchi A, Miyoshi J, Takai Y, Hata Y
Mol Cell Biol. 2007
PubMed ID: 17438139
Puromycin insensitive leucyl-specific aminopeptidase (PILSAP) affects RhoA activation in endothelial cells.
Suzuki T, Abe M, Miyashita H, Kobayashi T, Sato Y
J Cell Physiol. 2007
PubMed ID: 17385722
Cellular regulation of basal tone in internal anal sphincter smooth muscle by RhoA/ROCK.
Patel CA, Rattan S
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17379756
Roles of glial p75NTR in axonal regeneration.
Zhou XF, Li HY
J Neurosci Res. 2007
PubMed ID: 17335080
Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation.
Bulhak A, Roy J, Hedin U, Sjöquist PO, Pernow J
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17322412
Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation.
Koh E, Clair T, Hermansen R, Bandle RW, Schiffmann E, Roberts DD, Stracke ML
Cell Signal. 2007
PubMed ID: 17307336
Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.
Lartey J, Smith M, Pawade J, Strachan B, Mellor H, López Bernal A
Biol Reprod. 2007
PubMed ID: 17301291
Regulator of G-protein signalling 3 redirects prototypical Gi-coupled receptors from Rac1 to RhoA activation.
Vogt A, Lutz S, Rümenapp U, Han L, Jakobs KH, Schmidt M, Wieland T
Cell Signal. 2007
PubMed ID: 17300916
Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway.
Tumbarello DA, Turner CE
J Cell Physiol. 2007
PubMed ID: 17299801
Activators of the PKA and PKG pathways attenuate RhoA-mediated suppression of the KDR current in cerebral arteries.
Luykenaar KD, Welsh DG
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17277021
Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA.
Zhang SJ, Truskey GA, Kraus WE
Am J Physiol Cell Physiol. 2007
PubMed ID: 17267546
Load-induced focal adhesion mechanotransduction is altered with aging in the Fischer 344/NNiaHSd x Brown Norway/BiNia rat aorta.
Rice KM, Desai DH, Kinnard RS, Harris R, Wright GL, Blough ER
Biogerontology. 2007
PubMed ID: 17136425
The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin.
Arakawa Y, Cordeiro JV, Schleich S, Newsome TP, Way M
Cell Host Microbe. 2007
PubMed ID: 18005701
F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during vaccinia virus infection.
Arakawa Y, Cordeiro JV, Way M
Cell Host Microbe. 2007
PubMed ID: 18005700
Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathway.
Zhao XH, Laschinger C, Arora P, Szászi K, Kapus A, McCulloch CA
J Cell Sci. 2007
PubMed ID: 17456553
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate.
Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB
EMBO J. 2007
PubMed ID: 17446864
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.
Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM
Dev Cell. 2007
PubMed ID: 17488622
The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.
Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ
Mol Biol Cell. 2007
PubMed ID: 17332506
Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
Shi HY, Stafford LJ, Liu Z, Liu M, Zhang M
Cell Motil Cytoskeleton. 2007
PubMed ID: 17301947
Nitric oxide inhibits enterocyte migration through activation of RhoA-GTPase in a SHP-2-dependent manner.
Cetin S, Leaphart CL, Li J, Ischenko I, Hayman M, Upperman J, Zamora R, Watkins S, Ford HR, Wang J, Hackam DJ
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17272518
Rho-family small GTPases are involved in forskolin-induced cell-cell contact formation of renal glomerular podocytes in vitro.
Gao SY, Li CY, Shimokawa T, Terashita T, Matsuda S, Yaoita E, Kobayashi N
Cell Tissue Res. 2007
PubMed ID: 17265067
Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death.
Semenova MM, Mäki-Hokkonen AM, Cao J, Komarovski V, Forsberg KM, Koistinaho M, Coffey ET, Courtney MJ
Nat Neurosci. 2007
PubMed ID: 17369826
Re-expression of proteins involved in cytokinesis during cardiac hypertrophy.
Ahuja P, Perriard E, Pedrazzini T, Satoh S, Perriard JC, Ehler E
Exp Cell Res. 2007
PubMed ID: 17316608
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway.
Hatzoglou A, Ader I, Splingard A, Flanders J, Saade E, Leroy I, Traver S, Aresta S, de Gunzburg J
Mol Biol Cell. 2007
PubMed ID: 17267693
p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways.
Shang X, Moon SY, Zheng Y
J Biol Chem. 2007
PubMed ID: 17272280
RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.
Del Re DP, Miyamoto S, Brown JH
J Biol Chem. 2007
PubMed ID: 17234627
Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin.
Singh I, Knezevic N, Ahmmed GU, Kini V, Malik AB, Mehta D
J Biol Chem. 2007
PubMed ID: 17197445
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells.
Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360533
Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons.
Zhang Y, Gu X, Yuan X
Eur J Neurosci. 2007
PubMed ID: 17425560
Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility.
Xia M, Land H
Nat Struct Mol Biol. 2007
PubMed ID: 17310253
Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors.
Touge H, Chikumi H, Igishi T, Kurai J, Makino H, Tamura Y, Takata M, Yoneda K, Nakamoto M, Suyama H, Gutkind JS, Shimizu E
Int J Oncol. 2007
PubMed ID: 17273773
Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.
Guilluy C, Rolli-Derkinderen M, Tharaux PL, Melino G, Pacaud P, Loirand G
J Biol Chem. 2007
PubMed ID: 17142836
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure.
Ybot-Gonzalez P, Savery D, Gerrelli D, Signore M, Mitchell CE, Faux CH, Greene ND, Copp AJ
Development. 2007
PubMed ID: 17229766
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H
Infect Immun. 2007
PubMed ID: 17145947
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.
Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS
Blood. 2007
PubMed ID: 17018860
Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA.
Zuckerbraun BS, Stoyanovsky DA, Sengupta R, Shapiro RA, Ozanich BA, Rao J, Barbato JE, Tzeng E
Am J Physiol Cell Physiol. 2007
PubMed ID: 16914531
MAGI-3 regulates LPA-induced activation of Erk and RhoA.
Zhang H, Wang D, Sun H, Hall RA, Yun CC
Cell Signal. 2007
PubMed ID: 16904289
The full-ORF clone resource of the German cDNA Consortium.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC Genomics. 2007
PubMed ID: 17974005
Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase.
Eickholt BJ, Ahmed AI, Davies M, Papakonstanti EA, Pearce W, Starkey ML, Bilancio A, Need AC, Smith AJ, Hall SM, Hamers FP, Giese KP, Bradbury EJ, Vanhaesebroeck B
PLoS ONE. 2007
PubMed ID: 17846664
Developmental expression of three small GTPases in the mouse eye.
Mitchell DC, Bryan BA, Liu JP, Liu WB, Zhang L, Qu J, Zhou X, Liu M, Li DW
Mol Vis. 2007
PubMed ID: 17653061
Distribution and expression of RhoA in rat retina after optic nerve injury.
Wang YH, Wang Y, Wang DW, Wu N, Liu DN, Yin ZQ
Ophthalmic Res. 2007
PubMed ID: 17534117
Expression of RhoA by inflammatory macrophages and T cells in rat experimental autoimmune neuritis.
Zhang Z, Fauser U, Schluesener HJ
J Cell Mol Med. 2007
PubMed ID: 17367505
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
Sahai E, Garcia-Medina R, Pouysségur J, Vial E
J Cell Biol. 2007
PubMed ID: 17190792
PDGF signaling specificity is mediated through multiple immediate early genes.
Schmahl J, Raymond CS, Soriano P
Nat Genet. 2007
PubMed ID: 17143286
RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility.
Chang YW, Marlin JW, Chance TW, Jakobi R
Cancer Res. 2006
PubMed ID: 17178865
Inhibition of Rho A activity causes pemphigus skin blistering.
Waschke J, Spindler V, Bruggeman P, Zillikens D, Schmidt G, Drenckhahn D
J Cell Biol. 2006
PubMed ID: 17130286
Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway.
Saka M, Obata K, Ichihara S, Cheng XW, Kimata H, Noda A, Izawa H, Nagata K, Yokota M
Clin Exp Pharmacol Physiol. 2006
PubMed ID: 17184496
The armadillo protein p0071 regulates Rho signalling during cytokinesis.
Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M
Nat Cell Biol. 2006
PubMed ID: 17115030
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome.
Joshi S, Guleria RS, Pan J, Bayless KJ, Davis GE, Dipette D, Singh US
Cell Mol Life Sci. 2006
PubMed ID: 17109064
Increased Rho activation and PKC-mediated smooth muscle contractility in the absence of caveolin-1.
Shakirova Y, Bonnevier J, Albinsson S, Adner M, Rippe B, Broman J, Arner A, Swärd K
Am J Physiol Cell Physiol. 2006
PubMed ID: 17102036
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.
Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA
J Cell Sci. 2006
PubMed ID: 17077126
Hypoxia-induced upregulation of endothelial small G protein RhoA and Rho-kinase/ROCK2 inhibits eNOS expression.
Jin HG, Yamashita H, Nagano Y, Fukuba H, Hiji M, Ohtsuki T, Takahashi T, Kohriyama T, Kaibuchi K, Matsumoto M
Neurosci Lett. 2006
PubMed ID: 16996686
Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived str
Meriane M, Duhamel S, Lejeune L, Galipeau J, Annabi B
Stem Cells. 2006
PubMed ID: 16931773
RhoA protein expression correlates positively with degree of malignancy in astrocytomas.
Yan B, Chour HH, Peh BK, Lim C, Salto-Tellez M
Neurosci Lett. 2006
PubMed ID: 16978776
Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma.
Pan Q, Bao LW, Teknos TN, Merajver SD
Cancer Res. 2006
PubMed ID: 17018591
Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer.
Pillé JY, Li H, Blot E, Bertrand JR, Pritchard LL, Opolon P, Maksimenko A, Lu H, Vannier JP, Soria J, Malvy C, Soria C
Hum Gene Ther. 2006
PubMed ID: 17007568
Neuropeptide-stimulated cell migration in prostate cancer cells is mediated by RhoA kinase signaling and inhibited by neutral endopeptidase.
Zheng R, Iwase A, Shen R, Goodman OB, Sugimoto N, Takuwa Y, Lerner DJ, Nanus DM
Oncogene. 2006
PubMed ID: 16652149
Transforming growth factor-beta1 regulates macrophage migration via RhoA.
Kim JS, Kim JG, Moon MY, Jeon CY, Won HY, Kim HJ, Jeon YJ, Seo JY, Kim JI, Kim J, Lee JY, Kim PH, Park JB
Blood. 2006
PubMed ID: 16705092
Rapid translocation and insertion of the epithelial Na+ channel in response to RhoA signaling.
Pochynyuk O, Medina J, Gamper N, Genth H, Stockand JD, Staruschenko A
J Biol Chem. 2006
PubMed ID: 16829523
[Activation of RHOA gene transcription in epithelial tumors may be caused by gene amplification and/or demethylation of its promotor region]
Braga EA, Loginov VI, Klimov EA, Kilosanidze G, Khodyrev DS, Kaganova NL, Kazybskaia TP, Ermilova VD, Gar'kavtseva RF, Pronina IV, Rud'ko OI, Zabarskiĭ ER, Sulimova GE, Kiselev LL
Mol Biol (Mosk). 2006
PubMed ID: 17086988
Differential requirement for RhoA GTPase depending on the cellular localization of protein kinase D.
Mullin MJ, Lightfoot K, Marklund U, Cantrell DA
J Biol Chem. 2006
PubMed ID: 16772297
Intrahepatic upregulation of RhoA and Rho-kinase signalling contributes to increased hepatic vascular resistance in rats with secondary biliary cirrhosis.
Zhou Q, Hennenberg M, Trebicka J, Jochem K, Leifeld L, Biecker E, Sauerbruch T, Heller J
Gut. 2006
PubMed ID: 16492715
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling.
Lim WG, Tan BJ, Zhu Y, Zhou S, Armstrong JS, Li QT, Dong Q, Chan E, Smith D, Verma C, Tan SL, Duan W
Cell Signal. 2006
PubMed ID: 16427251
Transforming growth factor-beta1-induced endothelial barrier dysfunction involves Smad2-dependent p38 activation and subsequent RhoA activation.
Lu Q, Harrington EO, Jackson H, Morin N, Shannon C, Rounds S
J Appl Physiol. 2006
PubMed ID: 16645187
Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling.
Kabuyama Y, Langer SJ, Polvinen K, Homma Y, Resing KA, Ahn NG
Mol Cell Proteomics. 2006
PubMed ID: 16644720
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Dreissigacker U, Mueller MS, Unger M, Siegert P, Genze F, Gierschik P, Giehl K
Cell Signal. 2006
PubMed ID: 16257181
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front.
Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR
J Cell Biol. 2006
PubMed ID: 16864657
Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation.
Lakhe-Reddy S, Khan S, Konieczkowski M, Jarad G, Wu KL, Reichardt LF, Takai Y, Bruggeman LA, Wang B, Sedor JR, Schelling JR
J Biol Chem. 2006
PubMed ID: 16690620
PKCbeta-dependent activation of RhoA by syndecan-4 during focal adhesion formation.
Dovas A, Yoneda A, Couchman JR
J Cell Sci. 2006
PubMed ID: 16787950
RhoA and p38 MAPK mediate apoptosis induced by cellular cholesterol depletion.
Calleros L, Lasa M, Rodríguez-Alvarez FJ, Toro MJ, Chiloeches A
Apoptosis. 2006
PubMed ID: 16699960
Lysophosphatidic acid stimulates PC-3 prostate cancer cell Matrigel invasion through activation of RhoA and NF-kappaB activity.
Hwang YS, Hodge JC, Sivapurapu N, Lindholm PF
Mol Carcinog. 2006
PubMed ID: 16402387
RhoA and Rac1 contribute to type III group B streptococcal invasion of human brain microvascular endothelial cells.
Shin S, Kim KS
Biochem Biophys Res Commun. 2006
PubMed ID: 16681996
Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
Zeng Y, Zhuang S, Gloddek J, Tseng CC, Boss GR, Pilz RB
J Biol Chem. 2006
PubMed ID: 16632465
Fine regulation of RhoA and Rock is required for skeletal muscle differentiation.
Castellani L, Salvati E, Alemà S, Falcone G
J Biol Chem. 2006
PubMed ID: 16574652
Modulation by bradykinin of angiotensin type 1 receptor-evoked RhoA activation of connective tissue growth factor expression in human lung fibroblasts.
Huang Z, Taylor L, Liu B, Yu J, Polgar P
Am J Physiol Lung Cell Mol Physiol. 2006
PubMed ID: 16684954
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.
Boyer L, Turchi L, Desnues B, Doye A, Ponzio G, Mege JL, Yamashita M, Zhang YE, Bertoglio J, Flatau G, Boquet P, Lemichez E
Mol Biol Cell. 2006
PubMed ID: 16540523
RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.
Woods A, Beier F
J Biol Chem. 2006
PubMed ID: 16565087
Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.
Kurihara R, Tohyama Y, Matsusaka S, Naruse H, Kinoshita E, Tsujioka T, Katsumata Y, Yamamura H
J Biol Chem. 2006
PubMed ID: 16513651
Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling.
Asanuma K, Yanagida-Asanuma E, Faul C, Tomino Y, Kim K, Mundel P
Nat Cell Biol. 2006
PubMed ID: 16622418
Role of RhoA/ROCK-dependent actin contractility in the induction of tenascin-C by cyclic tensile strain.
Sarasa-Renedo A, Tunç-Civelek V, Chiquet M
Exp Cell Res. 2006
PubMed ID: 16448650
Role of heterotrimeric G-proteins in lysophosphatidic acid-mediated neurite retraction by RhoA-dependent and -independent mechanisms in N1E-115 cells.
Couvillon AD, Exton JH
Cell Signal. 2006
PubMed ID: 16122906
Serine phosphorylation differentially affects RhoA binding to effectors: implications to NGF-induced neurite outgrowth.
Nusser N, Gosmanova E, Makarova N, Fujiwara Y, Yang L, Guo F, Luo Y, Zheng Y, Tigyi G
Cell Signal. 2006
PubMed ID: 16109481
The DNA sequence, annotation and analysis of human chromosome 3.
Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA
Nature. 2006
PubMed ID: 16641997
Spatiotemporal dynamics of RhoA activity in migrating cells.
Pertz O, Hodgson L, Klemke RL, Hahn KM
Nature. 2006
PubMed ID: 16547516
Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.
Tanaka H, Katoh H, Negishi M
J Biol Chem. 2006
PubMed ID: 16481321
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
Zhao M, Janas JA, Niki M, Pandolfi PP, Van Aelst L
Mol Cell Biol. 2006
PubMed ID: 16537894
Cell surface transglutaminase promotes RhoA activation via integrin clustering and suppression of the Src-p190RhoGAP signaling pathway.
Janiak A, Zemskov EA, Belkin AM
Mol Biol Cell. 2006
PubMed ID: 16452636
Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism.
Wong K, Pertz O, Hahn K, Bourne H
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16537448
RhoA signaling in phorbol ester-induced apoptosis.
Chang ZF, Lee HH
J Biomed Sci. 2006
PubMed ID: 16496227
Elevated RhoA/Rho-kinase activity in the aged rat penis: mechanism for age-associated erectile dysfunction.
Jin L, Liu T, Lagoda GA, Champion HC, Bivalacqua TJ, Burnett AL
FASEB J. 2006
PubMed ID: 16396994
Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.
Dadke D, Jarnik M, Pugacheva EN, Singh MK, Golemis EA
Mol Biol Cell. 2006
PubMed ID: 16394104
SAGE reveals expression of Wnt signalling pathway members during mouse prostate development.
Zhang TJ, Hoffman BG, Ruiz de Algara T, Helgason CD
Gene Expr Patterns. 2006
PubMed ID: 16378759
Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat.
Nagaoka T, Gebb SA, Karoor V, Homma N, Morris KG, McMurtry IF, Oka M
J Appl Physiol. 2006
PubMed ID: 16322374
Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland.
Khan OY, Fu G, Ismail A, Srinivasan S, Cao X, Tu Y, Lu S, Nawaz Z
Mol Endocrinol. 2006
PubMed ID: 16254014
Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.
Niiya F, Tatsumoto T, Lee KS, Miki T
Oncogene. 2006
PubMed ID: 16247472
RhoA GTPase regulates M-cadherin activity and myoblast fusion.
Charrasse S, Comunale F, Grumbach Y, Poulat F, Blangy A, Gauthier-Rouvière C
Mol Biol Cell. 2006
PubMed ID: 16291866
Coupling of cell migration with neurogenesis by proneural bHLH factors.
Ge W, He F, Kim KJ, Blanchi B, Coskun V, Nguyen L, Wu X, Zhao J, Heng JI, Martinowich K, Tao J, Wu H, Castro D, Sobeih MM, Corfas G, Gleeson JG, Greenberg ME, Guillemot F, Sun YE
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432194
Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner.
Schubert V, Da Silva JS, Dotti CG
J Cell Biol. 2006
PubMed ID: 16449195
Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.
Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D
J Biol Chem. 2006
PubMed ID: 16308318
Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling.
Valderrama F, Cordeiro JV, Schleich S, Frischknecht F, Way M
Science. 2006
PubMed ID: 16424340
RhoA modulates Smad signaling during transforming growth factor-beta-induced smooth muscle differentiation.
Chen S, Crawford M, Day RM, Briones VR, Leader JE, Jose PA, Lechleider RJ
J Biol Chem. 2006
PubMed ID: 16317010
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
Moeller ML, Shi Y, Reichardt LF, Ethell IM
J Biol Chem. 2006
PubMed ID: 16298995
The RhoA/ROCK-I/MLC pathway is involved in the ethanol-induced apoptosis by anoikis in astrocytes.
Miñambres R, Guasch RM, Perez-Aragó A, Guerri C
J Cell Sci. 2006
PubMed ID: 16390872
RhoA signaling modulates cyclin D1 expression in human lung fibroblasts; implications for idiopathic pulmonary fibrosis.
Watts KL, Cottrell E, Hoban PR, Spiteri MA
Respir Res. 2006
PubMed ID: 16776827
Degradation of RhoA by Smurf1 ubiquitin ligase.
Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL
Methods Enzymol. 2006
PubMed ID: 16472676
Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion.
Bartolomé RA, Molina-Ortiz I, Samaniego R, Sánchez-Mateos P, Bustelo XR, Teixidó J
Cancer Res. 2006
PubMed ID: 16397238
Regulation of microtubule dynamics in 3T3 fibroblasts by Rho family GTPases.
Grigoriev I, Borisy G, Vorobjev I
Cell Motil Cytoskeleton. 2006
PubMed ID: 16362953
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.
Nishimura Y, Yonemura S
J Cell Sci. 2006
PubMed ID: 16352658
Rho-kinase as a molecular target for insulin resistance and hypertension.
Kanda T, Wakino S, Homma K, Yoshioka K, Tatematsu S, Hasegawa K, Takamatsu I, Sugano N, Hayashi K, Saruta T
FASEB J. 2006
PubMed ID: 16267124
Dissecting the role of Rho-mediated signaling in contractile ring formation.
Kamijo K, Ohara N, Abe M, Uchimura T, Hosoya H, Lee JS, Miki T
Mol Biol Cell. 2006
PubMed ID: 16236794
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment.
Wang L, Yang L, Filippi MD, Williams DA, Zheng Y
Blood. 2006
PubMed ID: 16174757
Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages.
Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park JH, Ha KS, Kim PH, Park JB
Exp Mol Med. 2005
PubMed ID: 16391519
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension.
Guilluy C, Sauzeau V, Rolli-Derkinderen M, Guérin P, Sagan C, Pacaud P, Loirand G
Br J Pharmacol. 2005
PubMed ID: 16205723
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation.
Zeng L, Xu H, Chew TL, Eng E, Sadeghi MM, Adler S, Kanwar YS, Danesh FR
FASEB J. 2005
PubMed ID: 16160062
Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner.
Niiya F, Xie X, Lee KS, Inoue H, Miki T
J Biol Chem. 2005
PubMed ID: 16118207
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity.
Leung TH, Ching YP, Yam JW, Wong CM, Yau TO, Jin DY, Ng IO
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16217026
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, Comoglio PM, Tamagnone L
J Cell Sci. 2005
PubMed ID: 16188938
GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.
Winkler S, Mohl M, Wieland T, Lutz S
Biochem Biophys Res Commun. 2005
PubMed ID: 16112081
Multiple signals regulate axon regeneration through the Nogo receptor complex.
Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F
Mol Neurobiol. 2005
PubMed ID: 16215275
Overexpression of RhoA-GTP induces activation of the Epidermal Growth Factor Receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells.
Cáceres M, Guerrero J, Martínez J
Exp Cell Res. 2005
PubMed ID: 15963982
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Control of the direction of lamellipodia extension through changes in the balance between Rac and Rho activities.
Brock AL, Ingber DE
Mol Cell Biomech. 2005
PubMed ID: 16708475
alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells.
Urbinati C, Bugatti A, Giacca M, Schlaepfer D, Presta M, Rusnati M
J Cell Sci. 2005
PubMed ID: 16105876
Localized RhoA activation as a requirement for the induction of membrane ruffling.
Kurokawa K, Matsuda M
Mol Biol Cell. 2005
PubMed ID: 15987744
Glycine-extended gastrin stimulates cell proliferation and migration through a Rho- and ROCK-dependent pathway, not a Rac/Cdc42-dependent pathway.
He H, Pannequin J, Tantiongco JP, Shulkes A, Baldwin GS
Am J Physiol Gastrointest Liver Physiol. 2005
PubMed ID: 15845872
Local translation of RhoA regulates growth cone collapse.
Wu KY, Hengst U, Cox LJ, Macosko EZ, Jeromin A, Urquhart ER, Jaffrey SR
Nature. 2005
PubMed ID: 16107849
An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Yüce O, Piekny A, Glotzer M
J Cell Biol. 2005
PubMed ID: 16103226
Negative control of keratinocyte differentiation by Rho/CRIK signaling coupled with up-regulation of KyoT1/2 (FHL1) expression.
Grossi M, Hiou-Feige A, Tommasi Di Vignano A, Calautti E, Ostano P, Lee S, Chiorino G, Dotto GP
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16061799
Integrin regulation by RhoA in thymocytes.
Vielkind S, Gallagher-Gambarelli M, Gomez M, Hinton HJ, Cantrell DA
J Immunol. 2005
PubMed ID: 15972668
Nuclear translocation of the SRF co-activator MAL in cortical neurons: role of RhoA signalling.
Tabuchi A, Estevez M, Henderson JA, Marx R, Shiota J, Nakano H, Baraban JM
J Neurochem. 2005
PubMed ID: 15953360
RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation.
Patel S, Takagi KI, Suzuki J, Imaizumi A, Kimura T, Mason RM, Kamimura T, Zhang Z
J Am Soc Nephrol. 2005
PubMed ID: 15901767
Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA.
Meyer DK, Fischer C, Becker U, Göttsching I, Boutillier S, Baermann C, Schmidt G, Klugbauer N, Leemhuis J
J Biol Chem. 2005
PubMed ID: 15870074
Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines.
Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ
Mol Biol Cell. 2005
PubMed ID: 15843433
Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome-mediated degradation in vascular smooth muscle cells.
Rolli-Derkinderen M, Sauzeau V, Boyer L, Lemichez E, Baron C, Henrion D, Loirand G, Pacaud P
Circ Res. 2005
PubMed ID: 15890975
Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.
Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, Huff MW
J Biol Chem. 2005
PubMed ID: 15817453
A novel protein kinase C (PKCepsilon) is required for fMet-Leu-Phe-induced activation of NF-kappaB in human peripheral blood monocytes.
Chen LY, Doerner A, Lehmann PF, Huang S, Zhong G, Pan ZK
J Biol Chem. 2005
PubMed ID: 15809302
Rac1/Cdc42 and RhoA GTPases antagonistically regulate chondrocyte proliferation, hypertrophy, and apoptosis.
Wang G, Beier F
J Bone Miner Res. 2005
PubMed ID: 15883643
Structural and mechanistic insights into the interaction between Rho and mammalian Dia.
Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian MR, Wittinghofer A
Nature. 2005
PubMed ID: 15864301
Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.
Kiyan J, Kiyan R, Haller H, Dumler I
EMBO J. 2005
PubMed ID: 15889147
Physical and functional interactions of the lysophosphatidic acid receptors with PDZ domain-containing Rho guanine nucleotide exchange factors (RhoGEFs).
Yamada T, Ohoka Y, Kogo M, Inagaki S
J Biol Chem. 2005
PubMed ID: 15755723
BCL6 suppresses RhoA activity to alter macrophage morphology and motility.
Pixley FJ, Xiong Y, Yu RY, Sahai EA, Stanley ER, Ye BH
J Cell Sci. 2005
PubMed ID: 15860730
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, Fauq A, Koo EH, Golde TE
Nat Med. 2005
PubMed ID: 15834426
Asymmetric membrane ganglioside sialidase activity specifies axonal fate.
Da Silva JS, Hasegawa T, Miyagi T, Dotti CG, Abad-Rodriguez J
Nat Neurosci. 2005
PubMed ID: 15834419
Structural basis of Rho GTPase-mediated activation of the formin mDia1.
Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK
Mol Cell. 2005
PubMed ID: 15866170
Muscle-specific signaling mechanism that links actin dynamics to serum response factor.
Kuwahara K, Barrientos T, Pipes GC, Li S, Olson EN
Mol Cell Biol. 2005
PubMed ID: 15798203
Regulation of PTEN by Rho small GTPases.
Li Z, Dong X, Dong X, Wang Z, Liu W, Deng N, Ding Y, Tang L, Hla T, Zeng R, Li L, Wu D
Nat Cell Biol. 2005
PubMed ID: 15793569
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P
Nat Cell Biol. 2005
PubMed ID: 15793564
AT2 receptors cross talk with AT1 receptors through a nitric oxide- and RhoA-dependent mechanism resulting in decreased phospholipase D activity.
Andresen BT, Shome K, Jackson EK, Romero GG
Am J Physiol Renal Physiol. 2005
PubMed ID: 15572519
Impaired agonist-dependent myosin phosphorylation and decreased RhoA in rat portal hypertensive mesenteric vasculature.
Zhang HY, Shirasawa Y, Chen X, Yu H, Benoit JN
Am J Physiol Gastrointest Liver Physiol. 2005
PubMed ID: 15513955
RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.
Woods A, Wang G, Beier F
J Biol Chem. 2005
PubMed ID: 15665004
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
Gajate C, Mollinedo F
J Biol Chem. 2005
PubMed ID: 15659383
RhoE function is regulated by ROCK I-mediated phosphorylation.
Riento K, Totty N, Villalonga P, Garg R, Guasch R, Ridley AJ
EMBO J. 2005
PubMed ID: 15775972
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.
Saeki N, Tokuo H, Ikebe M
J Biol Chem. 2005
PubMed ID: 15644318
Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.
Ohkawara H, Ishibashi T, Sakamoto T, Sugimoto K, Nagata K, Yokoyama K, Sakamoto N, Kamioka M, Matsuoka I, Fukuhara S, Sugimoto N, Takuwa Y, Maruyama Y
J Biol Chem. 2005
PubMed ID: 15640525
Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1.
Zhou H, Kramer RH
J Biol Chem. 2005
PubMed ID: 15611088
High-throughput mapping of a dynamic signaling network in mammalian cells.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL
Science. 2005
PubMed ID: 15761153
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor.
Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ
Chem Biol. 2005
PubMed ID: 15797222
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
Satchi-Fainaro R, Mamluk R, Wang L, Short SM, Nagy JA, Feng D, Dvorak AM, Dvorak HF, Puder M, Mukhopadhyay D, Folkman J
Cancer Cell. 2005
PubMed ID: 15766663
Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A.
Ahmed Z, Dent RG, Suggate EL, Barrett LB, Seabright RJ, Berry M, Logan A
Mol Cell Neurosci. 2005
PubMed ID: 15737741
Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.
Hayashi M, Sakata M, Takeda T, Tahara M, Yamamoto T, Minekawa R, Isobe A, Tasaka K, Murata Y
J Clin Endocrinol Metab. 2005
PubMed ID: 15598682
Statins suppress oxidized low density lipoprotein-induced macrophage proliferation by inactivation of the small G protein-p38 MAPK pathway.
Senokuchi T, Matsumura T, Sakai M, Yano M, Taguchi T, Matsuo T, Sonoda K, Kukidome D, Imoto K, Nishikawa T, Kim-Mitsuyama S, Takuwa Y, Araki E
J Biol Chem. 2005
PubMed ID: 15611087
Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.
Phillips HM, Murdoch JN, Chaudhry B, Copp AJ, Henderson DJ
Circ Res. 2005
PubMed ID: 15637299
BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.
Zhou YT, Guy GR, Low BC
Exp Cell Res. 2005
PubMed ID: 15652341
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth.
Bryan B, Cai Y, Wrighton K, Wu G, Feng XH, Liu M
FEBS Lett. 2005
PubMed ID: 15710384
Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo.
Pillé JY, Denoyelle C, Varet J, Bertrand JR, Soria J, Opolon P, Lu H, Pritchard LL, Vannier JP, Malvy C, Soria C, Li H
Mol Ther. 2005
PubMed ID: 15668138
Differential effects of RhoA signaling on anticancer agent-induced cell death.
Kang WK, Lee I, Ko U, Park C
Oncol Rep. 2005
PubMed ID: 15643515
RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.
Clements RT, Minnear FL, Singer HA, Keller RS, Vincent PA
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 15475381
RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes.
Yatani A, Irie K, Otani T, Abdellatif M, Wei L
Am J Physiol Heart Circ Physiol. 2005
PubMed ID: 15471984
Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells.
Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ
FEBS Lett. 2005
PubMed ID: 15670823
RhoA inactivation is crucial to manganese-induced astrocyte stellation.
Chen CJ, Liao SL, Huang YS, Chiang AN
Biochem Biophys Res Commun. 2005
PubMed ID: 15607750
The Rho family GTPase Rif induces filopodia through mDia2.
Pellegrin S, Mellor H
Curr Biol. 2005
PubMed ID: 15668168
RhoA GTPase regulates B cell receptor signaling.
Saci A, Carpenter CL
Mol Cell. 2005
PubMed ID: 15664190
Kidney expression of RhoA, TGF-beta1, and fibronectin in human IgA nephropathy.
Mattii L, Segnani C, Cupisti A, D'Alessandro D, Moscato S, Meola M, Barsotti G, Marinò M, Bianchi F, Dolfi A, Bernardini N
Nephron Exp Nephrol. 2005
PubMed ID: 15925904
Tagging genes with cassette-exchange sites.
Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R
Nucleic Acids Res. 2005
PubMed ID: 15741177
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis.
Fernandez-Zapico ME, Gonzalez-Paz NC, Weiss E, Savoy DN, Molina JR, Fonseca R, Smyrk TC, Chari ST, Urrutia R, Billadeau DD
Cancer Cell. 2005
PubMed ID: 15652748
Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.
Cestac P, Sarrabayrouse G, Médale-Giamarchi C, Rochaix P, Balaguer P, Favre G, Faye JC, Doisneau-Sixou S
Breast Cancer Res. 2005
PubMed ID: 15642170
MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration.
Zhang L, Deng M, Parthasarathy R, Wang L, Mongan M, Molkentin JD, Zheng Y, Xia Y
Mol Cell Biol. 2005
PubMed ID: 15601830
Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.
Blumenstein L, Ahmadian MR
J Biol Chem. 2004
PubMed ID: 15475352
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Oxidized LDL induces proliferation and hypertrophy in human umbilical vein endothelial cells via regulation of p27Kip1 expression: role of RhoA.
Seibold S, Schürle D, Heinloth A, Wolf G, Wagner M, Galle J
J Am Soc Nephrol. 2004
PubMed ID: 15579505
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.
Simpson KJ, Dugan AS, Mercurio AM
Cancer Res. 2004
PubMed ID: 15574779
RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.
Anwar KN, Fazal F, Malik AB, Rahman A
J Immunol. 2004
PubMed ID: 15557193
RhoA and Rac1 are both required for efficient wound closure of airway epithelial cells.
Desai LP, Aryal AM, Ceacareanu B, Hassid A, Waters CM
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15298851
Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.
Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE
J Biol Chem. 2004
PubMed ID: 15371459
RhoA activates purified phospholipase C-epsilon by a guanine nucleotide-dependent mechanism.
Seifert JP, Wing MR, Snyder JT, Gershburg S, Sondek J, Harden TK
J Biol Chem. 2004
PubMed ID: 15322077
Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.
Kristelly R, Gao G, Tesmer JJ
J Biol Chem. 2004
PubMed ID: 15331592
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.
Derewenda U, Oleksy A, Stevenson AS, Korczynska J, Dauter Z, Somlyo AP, Otlewski J, Somlyo AV, Derewenda ZS
Structure. 2004
PubMed ID: 15530360
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Jacinto E, Loewith R, Schmidt A, Lin S, Rüegg MA, Hall A, Hall MN
Nat Cell Biol. 2004
PubMed ID: 15467718
Cell type-specific regulation of RhoA activity during cytokinesis.
Yoshizaki H, Ohba Y, Parrini MC, Dulyaninova NG, Bresnick AR, Mochizuki N, Matsuda M
J Biol Chem. 2004
PubMed ID: 15308673
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase.
Janssen LJ, Tazzeo T, Zuo J, Pertens E, Keshavjee S
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15208091
Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity.
Liu N, Bi F, Pan Y, Sun L, Xue Y, Shi Y, Yao X, Zheng Y, Fan D
Clin Cancer Res. 2004
PubMed ID: 15448013
Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes.
Avalos AM, Arthur WT, Schneider P, Quest AF, Burridge K, Leyton L
J Biol Chem. 2004
PubMed ID: 15220352
Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1.
Matsuzawa T, Kuwae A, Yoshida S, Sasakawa C, Abe A
EMBO J. 2004
PubMed ID: 15318166
RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription.
Ling L, Lobie PE
J Biol Chem. 2004
PubMed ID: 15102857
The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization.
Miyoshi K, Wakioka T, Nishinakamura H, Kamio M, Yang L, Inoue M, Hasegawa M, Yonemitsu Y, Komiya S, Yoshimura A
Oncogene. 2004
PubMed ID: 15184877
Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.
Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS
J Cell Biol. 2004
PubMed ID: 15249579
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer.
Kamai T, Yamanishi T, Shirataki H, Takagi K, Asami H, Ito Y, Yoshida K
Clin Cancer Res. 2004
PubMed ID: 15269155
Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium.
Hirakawa M, Oike M, Karashima Y, Ito Y
J Physiol. 2004
PubMed ID: 15155793
Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility.
Tashiro A, Yuste R
Mol Cell Neurosci. 2004
PubMed ID: 15234347
The low molecular weight GTPase RhoA and atypical protein kinase Czeta are required for TLR2-mediated gene transcription.
Teusch N, Lombardo E, Eddleston J, Knaus UG
J Immunol. 2004
PubMed ID: 15210811
Rho kinase regulates the intracellular micromechanical response of adherent cells to rho activation.
Kole TP, Tseng Y, Huang L, Katz JL, Wirtz D
Mol Biol Cell. 2004
PubMed ID: 15146061
Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.
Mammoto A, Huang S, Moore K, Oh P, Ingber DE
J Biol Chem. 2004
PubMed ID: 15096506
Endotoxin inhibits intestinal epithelial restitution through activation of Rho-GTPase and increased focal adhesions.
Cetin S, Ford HR, Sysko LR, Agarwal C, Wang J, Neal MD, Baty C, Apodaca G, Hackam DJ
J Biol Chem. 2004
PubMed ID: 15169791
Distinct roles of Rac1/Cdc42 and Rho/Rock for axon outgrowth and nucleokinesis of precerebellar neurons toward netrin 1.
Causeret F, Hidalgo-Sanchez M, Fort P, Backer S, Popoff MR, Gauthier-Rouvière C, Bloch-Gallego E
Development. 2004
PubMed ID: 15151987
Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion.
Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S
Mol Cell. 2004
PubMed ID: 15125835
p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity.
Gehler S, Gallo G, Veien E, Letourneau PC
J Neurosci. 2004
PubMed ID: 15128850
Role of the Rhoa/Rho kinase system in flow-related remodeling of rat mesenteric small arteries in vivo.
Wesselman JP, Kuijs R, Hermans JJ, Janssen GM, Fazzi GE, van Essen H, Evelo CT, Struijker-Boudier HA, De Mey JG
J Vasc Res. 2004
PubMed ID: 15192268
Functional role of RhoA in growth regulation of primary hepatocytes.
Dohda T, Nakamura Y, Kamihira M, Iijima S
J Biochem. 2004
PubMed ID: 15173202
Rho localization in cells and tissues.
Yonemura S, Hirao-Minakuchi K, Nishimura Y
Exp Cell Res. 2004
PubMed ID: 15093731
p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene.
Lutz S, Freichel-Blomquist A, Rümenapp U, Schmidt M, Jakobs KH, Wieland T
Naunyn Schmiedebergs Arch Pharmacol. 2004
PubMed ID: 15069594
GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions.
van Nieuw Amerongen GP, Natarajan K, Yin G, Hoefen RJ, Osawa M, Haendeler J, Ridley AJ, Fujiwara K, van Hinsbergh VW, Berk BC
Circ Res. 2004
PubMed ID: 15016733
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S
Nature. 2004
PubMed ID: 15085137
Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase.
Kobayashi K, Takahashi M, Matsushita N, Miyazaki J, Koike M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K
J Neurosci. 2004
PubMed ID: 15071095
Raf and RhoA cooperate to transform intestinal epithelial cells and induce growth resistance to transforming growth factor beta.
Du J, Jiang B, Coffey RJ, Barnard J
Mol Cancer Res. 2004
PubMed ID: 15140945
Rho A participates in the regulation of phosphatidylserine-dependent procoagulant activity at the surface of megakaryocytic cells.
Kunzelmann C, Freyssinet JM, Martínez MC
J Thromb Haemost. 2004
PubMed ID: 15102021
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.
McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS
Dev Cell. 2004
PubMed ID: 15068789
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA.
Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F
Exp Cell Res. 2004
PubMed ID: 15023524
RhoA/ROCK signaling suppresses hypertrophic chondrocyte differentiation.
Wang G, Woods A, Sabari S, Pagnotta L, Stanton LA, Beier F
J Biol Chem. 2004
PubMed ID: 14726536
Matrix-specific activation of Src and Rho initiates capillary morphogenesis of endothelial cells.
Liu Y, Senger DR
FASEB J. 2004
PubMed ID: 15003991
RhoA activation promotes transendothelial migration of monocytes via ROCK.
Honing H, van den Berg TK, van der Pol SM, Dijkstra CD, van der Kammen RA, Collard JG, de Vries HE
J Leukoc Biol. 2004
PubMed ID: 14634067
Structural insights into the interaction of ROCKI with the switch regions of RhoA.
Dvorsky R, Blumenstein L, Vetter IR, Ahmadian MR
J Biol Chem. 2004
PubMed ID: 14660612
ERK activation by mechanical strain is regulated by the small G proteins rac-1 and rhoA.
Laboureau J, Dubertret L, Lebreton-De Coster C, Coulomb B
Exp Dermatol. 2004
PubMed ID: 15009099
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways.
Jaffe AB, Aspenström P, Hall A
Mol Cell Biol. 2004
PubMed ID: 14749388
RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity.
Gallagher ED, Gutowski S, Sternweis PC, Cobb MH
J Biol Chem. 2004
PubMed ID: 14581471
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways.
Gavard J, Lambert M, Grosheva I, Marthiens V, Irinopoulou T, Riou JF, Bershadsky A, Mège RM
J Cell Sci. 2004
PubMed ID: 14657280
Protein profile of tax-associated complexes.
Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F
J Biol Chem. 2004
PubMed ID: 14530271
The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells.
Paradiso A, Cardone RA, Bellizzi A, Bagorda A, Guerra L, Tommasino M, Casavola V, Reshkin SJ
Breast Cancer Res. 2004
PubMed ID: 15535843
Imaging filopodia dynamics in the mouse blastocyst.
Salas-Vidal E, Lomelí H
Dev Biol. 2004
PubMed ID: 14697354
TGF-beta-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest.
Bhowmick NA, Ghiassi M, Aakre M, Brown K, Singh V, Moses HL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14657354
Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA.
Surks HK, Richards CT, Mendelsohn ME
J Biol Chem. 2003
PubMed ID: 14506264
Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).
Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR
J Biol Chem. 2003
PubMed ID: 14514689
Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.
Cascone I, Giraudo E, Caccavari F, Napione L, Bertotti E, Collard JG, Serini G, Bussolino F
J Biol Chem. 2003
PubMed ID: 12972426
RhoA induces MMP-9 expression at CD44 lamellipodial focal complexes and promotes HMEC-1 cell invasion.
Abécassis I, Olofsson B, Schmid M, Zalcman G, Karniguian A
Exp Cell Res. 2003
PubMed ID: 14644158
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation.
Wang HR, Zhang Y, Ozdamar B, Ogunjimi AA, Alexandrova E, Thomsen GH, Wrana JL
Science. 2003
PubMed ID: 14657501
Upregulation of rhoA mRNA in bronchial smooth muscle of antigen-induced airway hyperresponsive rats.
Chiba Y, Sakai H, Wachi H, Sugitani H, Seyama Y, Misawa M
J Smooth Muscle Res. 2003
PubMed ID: 15048014
Activation of Rho GTPases by synaptic transmission in the hippocampus.
O'Kane EM, Stone TW, Morris BJ
J Neurochem. 2003
PubMed ID: 14622110
Repressions of actin assembly and RhoA localization are involved in inhibition of tumor cell motility by lipophilic ascorbyl phosphate.
Liu JW, Kayasuga A, Nagao N, Masatsuji-Kato E, Tuzuki T, Miwa N
Int J Oncol. 2003
PubMed ID: 14612927
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1.
Shang X, Zhou YT, Low BC
J Biol Chem. 2003
PubMed ID: 12944407
A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.
Wang L, Yang L, Luo Y, Zheng Y
J Biol Chem. 2003
PubMed ID: 12939257
RhoA-Rho kinase mediates synergistic ET-1 and phenylephrine contraction of rat corpus cavernosum.
Wingard CJ, Husain S, Williams J, James S
Am J Physiol Regul Integr Comp Physiol. 2003
PubMed ID: 12893655
Direct activation of phospholipase C-epsilon by Rho.
Wing MR, Snyder JT, Sondek J, Harden TK
J Biol Chem. 2003
PubMed ID: 12900402
Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA.
Moreau V, Tatin F, Varon C, Génot E
Mol Cell Biol. 2003
PubMed ID: 12972601
RhoA stimulates IEC-6 cell proliferation by increasing polyamine-dependent Cdk2 activity.
Guo H, Ray RM, Johnson LR
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12816757
RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.
Da Silva JS, Medina M, Zuliani C, Di Nardo A, Witke W, Dotti CG
J Cell Biol. 2003
PubMed ID: 14517206
Elastin induces myofibrillogenesis via a specific domain, VGVAPG.
Karnik SK, Wythe JD, Sorensen L, Brooke BS, Urness LD, Li DY
Matrix Biol. 2003
PubMed ID: 14614988
Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS.
Filbin MT
Nat Rev Neurosci. 2003
PubMed ID: 12951563
RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.
Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB
J Biol Chem. 2003
PubMed ID: 12766172
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12897243
RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression.
Zuckerbraun BS, Shapiro RA, Billiar TR, Tzeng E
Circulation. 2003
PubMed ID: 12874183
Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation.
Kawamura S, Miyamoto S, Brown JH
J Biol Chem. 2003
PubMed ID: 12777392
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progressio
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
J Biol Chem. 2003
PubMed ID: 12748184
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11.
Vogt S, Grosse R, Schultz G, Offermanns S
J Biol Chem. 2003
PubMed ID: 12771155
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Katoh H, Negishi M
Nature. 2003
PubMed ID: 12879077
The RhoA effector mDia is induced during T cell activation and regulates actin polymerization and cell migration in T lymphocytes.
Vicente-Manzanares M, Rey M, Pérez-Martínez M, Yáñez-Mó M, Sancho D, Cabrero JR, Barreiro O, de la Fuente H, Itoh K, Sánchez-Madrid F
J Immunol. 2003
PubMed ID: 12847276
p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.
Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T
Mol Biol Cell. 2003
PubMed ID: 12857875
Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer.
Kamai T, Tsujii T, Arai K, Takagi K, Asami H, Ito Y, Oshima H
Clin Cancer Res. 2003
PubMed ID: 12855641
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP.
Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman J, Der CJ, Hansen SH
Curr Biol. 2003
PubMed ID: 12842009
A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity.
Grosse R, Copeland JW, Newsome TP, Way M, Treisman R
EMBO J. 2003
PubMed ID: 12805219
Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.
Horiuchi A, Imai T, Wang C, Ohira S, Feng Y, Nikaido T, Konishi I
Lab Invest. 2003
PubMed ID: 12808121
RhoE binds to ROCK I and inhibits downstream signaling.
Riento K, Guasch RM, Garg R, Jin B, Ridley AJ
Mol Cell Biol. 2003
PubMed ID: 12773565
Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways.
Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C
Am J Physiol Cell Physiol. 2003
PubMed ID: 12584113
Distribution of Rho family GTPases in the adult rat hippocampus and cerebellum.
O'Kane EM, Stone TW, Morris BJ
Brain Res Mol Brain Res. 2003
PubMed ID: 12782387
Serine phosphorylation negatively regulates RhoA in vivo.
Ellerbroek SM, Wennerberg K, Burridge K
J Biol Chem. 2003
PubMed ID: 12654918
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S
Oncogene. 2003
PubMed ID: 12761501
Increased RhoA translocation in renal cortex of diabetic rats.
Massey AR, Miao L, Smith BN, Liu J, Kusaka I, Zhang JH, Tang J
Life Sci. 2003
PubMed ID: 12706482
Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.
Longenecker K, Read P, Lin SK, Somlyo AP, Nakamoto RK, Derewenda ZS
Acta Crystallogr D Biol Crystallogr. 2003
PubMed ID: 12777804
Urokinase-induced migration of human vascular smooth muscle cells requires coupling of the small GTPases RhoA and Rac1 to the Tyk2/PI3-K signalling pathway.
Kiian I, Tkachuk N, Haller H, Dumler I
Thromb Haemost. 2003
PubMed ID: 12719789
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.
Yamashita T, Tohyama M
Nat Neurosci. 2003
PubMed ID: 12692556
Integral role of RhoA activation in monocyte adhesion-triggered tissue factor expression in endothelial cells.
Ishibashi T, Sakamoto T, Ohkawara H, Nagata K, Sugimoto K, Sakurada S, Sugimoto N, Watanabe A, Yokoyama K, Sakamoto N, Kurabayashi M, Takuwa Y, Maruyama Y
Arterioscler Thromb Vasc Biol. 2003
PubMed ID: 12692008
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction.
Liu TS, Musch MW, Sugi K, Walsh-Reitz MM, Ropeleski MJ, Hendrickson BA, Pothoulakis C, Lamont JT, Chang EB
Am J Physiol Cell Physiol. 2003
PubMed ID: 12490434
RhoA expression is controlled by nitric oxide through cGMP-dependent protein kinase activation.
Sauzeau V, Rolli-Derkinderen M, Marionneau C, Loirand G, Pacaud P
J Biol Chem. 2003
PubMed ID: 12524425
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
Varker KA, Phelps SH, King MM, Williams CL
Int J Oncol. 2003
PubMed ID: 12579323
Activation of phospholipase D1 by ADP-ribosylated RhoA.
Genth H, Schmidt M, Gerhard R, Aktories K, Just I
Biochem Biophys Res Commun. 2003
PubMed ID: 12593858
Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP.
Moon SY, Zang H, Zheng Y
J Biol Chem. 2003
PubMed ID: 12454018
Biochemical characterization of the Yersinia YopT protease: cleavage site and recognition elements in Rho GTPases.
Shao F, Vacratsis PO, Bao Z, Bowers KE, Fierke CA, Dixon JE
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12538863
RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.
Kamai T, Kawakami S, Koga F, Arai G, Takagi K, Arai K, Tsujii T, Yoshida KI
BJU Int. 2003
PubMed ID: 12581011
Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells.
Greenberg DL, Mize GJ, Takayama TK
Biochemistry. 2003
PubMed ID: 12534282
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.
Suzuki N, Nakamura S, Mano H, Kozasa T
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12515866
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
Habas R, Dawid IB, He X
Genes Dev. 2003
PubMed ID: 12533515
Tissue transglutaminase mediates activation of RhoA and MAP kinase pathways during retinoic acid-induced neuronal differentiation of SH-SY5Y cells.
Singh US, Pan J, Kao YL, Joshi S, Young KL, Baker KM
J Biol Chem. 2003
PubMed ID: 12401808
Human uterine epithelial RL95-2 cells reorganize their cytoplasmic architecture with respect to Rho protein and F-actin in response to trophoblast binding.
Heneweer C, Adelmann HG, Kruse LH, Denker HW, Thie M
Cells Tissues Organs. 2003
PubMed ID: 14605490
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology.
Leung T, Ng Y, Cheong A, Ng CH, Tan I, Hall C, Lim L
FEBS Lett. 2002
PubMed ID: 12482610
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Côté JF, Vuori K
J Cell Sci. 2002
PubMed ID: 12432077
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration.
Shiokawa S, Iwashita M, Akimoto Y, Nagamatsu S, Sakai K, Hanashi H, Kabir-Salmani M, Nakamura Y, Uehata M, Yoshimura Y
J Clin Endocrinol Metab. 2002
PubMed ID: 12466390
Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N
Mol Cell Biol. 2002
PubMed ID: 12446789
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.
Zhao D, Kuhnt-Moore S, Zeng H, Pan A, Wu JS, Simeonidis S, Moyer MP, Pothoulakis C
Biochem J. 2002
PubMed ID: 12169092
CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion.
Doye A, Mettouchi A, Bossis G, Clément R, Buisson-Touati C, Flatau G, Gagnoux L, Piechaczyk M, Boquet P, Lemichez E
Cell. 2002
PubMed ID: 12437928
Characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors.
Tan YC, Wu H, Wang WN, Zheng Y, Wang ZX
Anal Biochem. 2002
PubMed ID: 12423633
The RhoA-binding protein, rhophilin-2, regulates actin cytoskeleton organization.
Peck JW, Oberst M, Bouker KB, Bowden E, Burbelo PD
J Biol Chem. 2002
PubMed ID: 12221077
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K
J Biol Chem. 2002
PubMed ID: 12221096
Isoprenylation is necessary for the full invasive potential of RhoA overexpression in human melanoma cells.
Collisson EA, Carranza DC, Chen IY, Kolodney MS
J Invest Dermatol. 2002
PubMed ID: 12445208
Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation.
Heneweer C, Kruse LH, Kindhäuser F, Schmidt M, Jakobs KH, Denker HW, Thie M
Mol Hum Reprod. 2002
PubMed ID: 12397214
cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions.
Gudi T, Chen JC, Casteel DE, Seasholtz TM, Boss GR, Pilz RB
J Biol Chem. 2002
PubMed ID: 12119292
IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription.
Chen LY, Zuraw BL, Liu FT, Huang S, Pan ZK
J Immunol. 2002
PubMed ID: 12244193
A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.
Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J
Biochem J. 2002
PubMed ID: 12093360
Roles of Rho-associated kinase and myosin light chain kinase in morphological and migratory defects of focal adhesion kinase-null cells.
Chen BH, Tzen JT, Bresnick AR, Chen HC
J Biol Chem. 2002
PubMed ID: 12105199
Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.
Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B
Br J Cancer. 2002
PubMed ID: 12237774
N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.
Charrasse S, Meriane M, Comunale F, Blangy A, Gauthier-Rouvière C
J Cell Biol. 2002
PubMed ID: 12213839
Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta.
Massoumi R, Larsson C, Sjölander A
J Cell Sci. 2002
PubMed ID: 12154081
High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling.
Psichari E, Balmain A, Plows D, Zoumpourlis V, Pintzas A
J Biol Chem. 2002
PubMed ID: 12039949
Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.
Hayashi K, Ohshima T, Mikoshiba K
Mol Cell Neurosci. 2002
PubMed ID: 12213441
RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification.
Solski PA, Helms W, Keely PJ, Su L, Der CJ
Cell Growth Differ. 2002
PubMed ID: 12193475
Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB
Am J Physiol Cell Physiol. 2002
PubMed ID: 12107060
Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats.
Miao L, Calvert JW, Tang J, Zhang JH
Life Sci. 2002
PubMed ID: 12095538
Potent activation of RhoA by Galpha q and Gq-coupled receptors.
Chikumi H, Vázquez-Prado J, Servitja JM, Miyazaki H, Gutkind JS
J Biol Chem. 2002
PubMed ID: 12016230
Expression and potential function of Rho family small G proteins in cells of the mammalian seminiferous epithelium.
Freeman EA, Jani P, Millette CE
Cell Commun Adhes. 2002
PubMed ID: 12699088
Extension, retraction and contraction in the formation of a dendritic cell dendrite: distinct roles for Rho GTPases.
Swetman CA, Leverrier Y, Garg R, Gan CH, Ridley AJ, Katz DR, Chain BM
Eur J Immunol. 2002
PubMed ID: 12115629
Regulation of cadherin junctions during mouse submandibular gland development.
Menko AS, Zhang L, Schiano F, Kreidberg JA, Kukuruzinska MA
Dev Dyn. 2002
PubMed ID: 12112462
Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.
Thodeti CK, Massoumi R, Bindslev L, Sjölander A
Biochem J. 2002
PubMed ID: 12071848
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
Booden MA, Siderovski DP, Der CJ
Mol Cell Biol. 2002
PubMed ID: 12024019
TGFbeta3-induced activation of RhoA/Rho-kinase pathway is necessary but not sufficient for epithelio-mesenchymal transdifferentiation: implications for palatogenesis.
Kaartinen V, Haataja L, Nagy A, Heisterkamp N, Groffen J
Int J Mol Med. 2002
PubMed ID: 12011971
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J
Nat Struct Biol. 2002
PubMed ID: 12006984
A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.
Shao F, Merritt PM, Bao Z, Innes RW, Dixon JE
Cell. 2002
PubMed ID: 12062101
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM
J Biol Chem. 2002
PubMed ID: 11839765
NGF enhances sensory axon growth induced by laminin but not by the L1 cell adhesion molecule.
Liu RY, Schmid RS, Snider WD, Maness PF
Mol Cell Neurosci. 2002
PubMed ID: 12056835
RhoA-dependent murine prostate cancer cell proliferation and apoptosis: role of protein kinase Czeta.
Ghosh PM, Bedolla R, Mikhailova M, Kreisberg JI
Cancer Res. 2002
PubMed ID: 11980660
RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.
Schoenwaelder SM, Hughan SC, Boniface K, Fernando S, Holdsworth M, Thompson PE, Salem HH, Jackson SP
J Biol Chem. 2002
PubMed ID: 11830597
The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases.
Nancy V, Callebaut I, El Marjou A, de Gunzburg J
J Biol Chem. 2002
PubMed ID: 11786539
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Himmel KL, Bi F, Shen H, Jenkins NA, Copeland NG, Zheng Y, Largaespada DA
J Biol Chem. 2002
PubMed ID: 11839748
Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases.
Stice LL, Forman LW, Hahn CS, Faller DV
Exp Cell Res. 2002
PubMed ID: 11925102
SmgGDS displays differential binding and exchange activity towards different Ras isoforms.
Vikis HG, Stewart S, Guan KL
Oncogene. 2002
PubMed ID: 11948427
Rho proteins, mental retardation and the cellular basis of cognition.
Ramakers GJ
Trends Neurosci. 2002
PubMed ID: 11998687
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ
Development. 2002
PubMed ID: 11923206
Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation.
Booden MA, Campbell SL, Der CJ
Mol Cell Biol. 2002
PubMed ID: 11909943
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.
Holstein SA, Wohlford-Lenane CL, Hohl RJ
J Biol Chem. 2002
PubMed ID: 11788600
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J
EMBO J. 2002
PubMed ID: 11889037
RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1.
Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Muñoz-Antonia T
J Biol Chem. 2002
PubMed ID: 11741970
High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis.
Beqaj S, Jakkaraju S, Mattingly RR, Pan D, Schuger L
J Cell Biol. 2002
PubMed ID: 11877460
MgF(3)(-) as a transition state analog of phosphoryl transfer.
Graham DL, Lowe PN, Grime GW, Marsh M, Rittinger K, Smerdon SJ, Gamblin SJ, Eccleston JF
Chem Biol. 2002
PubMed ID: 11927263
Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA.
Edlund S, Landström M, Heldin CH, Aspenström P
Mol Biol Cell. 2002
PubMed ID: 11907271
The rho/rho-kinase pathway is involved in the progression of testicular germ cell tumour.
Kamai T, Arai K, Sumi S, Tsujii T, Honda M, Yamanishi T, Yoshida KI
BJU Int. 2002
PubMed ID: 11872041
Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D.
Mansfield PJ, Hinkovska-Galcheva V, Carey SS, Shayman JA, Boxer LA
Blood. 2002
PubMed ID: 11830497
Involvement of Rho GTPases and their effectors in the secretory process of PC12 cells.
Frantz C, Coppola T, Regazzi R
Exp Cell Res. 2002
PubMed ID: 11822867
Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism.
Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA
J Neurosci. 2002
PubMed ID: 11826115
Expression and modulation of Rho kinase in human pregnant myometrium.
Moran CJ, Friel AM, Smith TJ, Cairns M, Morrison JJ
Mol Hum Reprod. 2002
PubMed ID: 11818523
Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.
Calautti E, Grossi M, Mammucari C, Aoyama Y, Pirro M, Ono Y, Li J, Dotto GP
J Cell Biol. 2002
PubMed ID: 11777936
A role for the Rho-p160 Rho coiled-coil kinase axis in the chemokine stromal cell-derived factor-1alpha-induced lymphocyte actomyosin and microtubular organization and chemotaxis.
Vicente-Manzanares M, Cabrero JR, Rey M, Pérez-Martínez M, Ursa A, Itoh K, Sánchez-Madrid F
J Immunol. 2002
PubMed ID: 11751986
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
Habas R, Kato Y, He X
Cell. 2001
PubMed ID: 11779461
Differential regulation of Rho and Rac through heterotrimeric G-proteins and cyclic nucleotides.
Gratacap MP, Payrastre B, Nieswandt B, Offermanns S
J Biol Chem. 2001
PubMed ID: 11560922
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Rihet S, Vielh P, Camonis J, Goud B, Chevillard S, de Gunzburg J
J Cancer Res Clin Oncol. 2001
PubMed ID: 11768613
Kinectin is a key effector of RhoG microtubule-dependent cellular activity.
Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P
Mol Cell Biol. 2001
PubMed ID: 11689693
Interaction with podocin facilitates nephrin signaling.
Huber TB, Kottgen M, Schilling B, Walz G, Benzing T
J Biol Chem. 2001
PubMed ID: 11562357
Ht31: the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling.
Klussmann E, Edemir B, Pepperle B, Tamma G, Henn V, Klauschenz E, Hundsrucker C, Maric K, Rosenthal W
FEBS Lett. 2001
PubMed ID: 11696353
Selective expression of the small GTPase RhoB in the early developing mouse lens.
Maddala R, Peng YW, Rao PV
Dev Dyn. 2001
PubMed ID: 11747086
Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y
Cell. 2001
PubMed ID: 11672528
The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils.
Adachi T, Vita R, Sannohe S, Stafford S, Alam R, Kayaba H, Chihara J
J Immunol. 2001
PubMed ID: 11591790
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases.
Figueroa C, Taylor J, Vojtek AB
J Biol Chem. 2001
PubMed ID: 11335720
Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.
Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ
J Biol Chem. 2001
PubMed ID: 11373293
PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins for Rho family.
Shibata H, Oishi K, Yamagiwa A, Matsumoto M, Mukai H, Ono Y
J Biochem. 2001
PubMed ID: 11432776
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2.
Singh US, Kunar MT, Kao YL, Baker KM
EMBO J. 2001
PubMed ID: 11350930
Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI).
Fauré J, Dagher MC
Biochimie. 2001
PubMed ID: 11368848
Determination of interaction sites of phospholipase D1 for RhoA.
Cai S, Exton JH
Biochem J. 2001
PubMed ID: 11311142
Interaction of protein kinase C isozymes with Rho GTPases.
Slater SJ, Seiz JL, Stagliano BA, Stubbs CD
Biochemistry. 2001
PubMed ID: 11284700
Loss of alpha3beta1 integrin function results in an altered differentiation program in the mouse submandibular gland.
Menko AS, Kreidberg JA, Ryan TT, Van Bockstaele E, Kukuruzinska MA
Dev Dyn. 2001
PubMed ID: 11307167
Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules.
van Horck FP, Ahmadian MR, Haeusler LC, Moolenaar WH, Kranenburg O
J Biol Chem. 2001
PubMed ID: 11058585
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
cGMP-dependent protein kinase phosphorylates and inactivates RhoA.
Sawada N, Itoh H, Yamashita J, Doi K, Inoue M, Masatsugu K, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K
Biochem Biophys Res Commun. 2001
PubMed ID: 11162591
PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10.
Neudauer CL, Joberty G, Macara IG
Biochem Biophys Res Commun. 2001
PubMed ID: 11162552
Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding.
Michaelson D, Silletti J, Murphy G, D'Eustachio P, Rush M, Philips MR
J Cell Biol. 2001
PubMed ID: 11149925
The semaphorin 3A receptor may directly regulate the activity of small GTPases.
Rohm B, Rahim B, Kleiber B, Hovatta I, Püschel AW
FEBS Lett. 2000
PubMed ID: 11108845
Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.
Blomquist A, Schwörer G, Schablowski H, Psoma A, Lehnen M, Jakobs KH, Rümenapp U
Biochem J. 2000
PubMed ID: 11085924
The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain.
Medley QG, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien SP, Streuli M
J Biol Chem. 2000
PubMed ID: 10948190
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The PDZ protein TIP-1 interacts with the Rho effector rhotekin and is involved in Rho signaling to the serum response element.
Reynaud C, Fabre S, Jalinot P
J Biol Chem. 2000
PubMed ID: 10940294
RhoA prenylation is required for promotion of cell growth and transformation and cytoskeleton organization but not for induction of serum response element transcription.
Allal C, Favre G, Couderc B, Salicio S, Sixou S, Hamilton AD, Sebti SM, Lajoie-Mazenc I, Pradines A
J Biol Chem. 2000
PubMed ID: 10896672
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation.
Zhu K, Debreceni B, Li R, Zheng Y
J Biol Chem. 2000
PubMed ID: 10854437
Asef, a link between the tumor suppressor APC and G-protein signaling.
Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T
Science. 2000
PubMed ID: 10947987
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism.
Shimizu T, Ihara K, Maesaki R, Kuroda S, Kaibuchi K, Hakoshima T
J Biol Chem. 2000
PubMed ID: 10748207
Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA.
Prakash SK, Paylor R, Jenna S, Lamarche-Vane N, Armstrong DL, Xu B, Mancini MA, Zoghbi HY
Hum Mol Genet. 2000
PubMed ID: 10699171
The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly.
Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W
Cell Death Differ. 2000
PubMed ID: 10713718
The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T
Mol Cell. 1999
PubMed ID: 10619026
Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth.
Yamashita T, Tucker KL, Barde YA
Neuron. 1999
PubMed ID: 10595511
Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins.
Movilla N, Bustelo XR
Mol Cell Biol. 1999
PubMed ID: 10523675
Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member.
Rümenapp U, Blomquist A, Schwörer G, Schablowski H, Psoma A, Jakobs KH
FEBS Lett. 1999
PubMed ID: 10526156
How RhoGDI binds Rho.
Longenecker K, Read P, Derewenda U, Dauter Z, Liu X, Garrard S, Walker L, Somlyo AV, Nakamoto RK, Somlyo AP, Derewenda ZS
Acta Crystallogr D Biol Crystallogr. 1999
PubMed ID: 10489445
RhoA interacts with the fusion glycoprotein of respiratory syncytial virus and facilitates virus-induced syncytium formation.
Pastey MK, Crowe JE, Graham BS
J Virol. 1999
PubMed ID: 10438814
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S
Science. 1999
PubMed ID: 10436159
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.
Watanabe N, Kato T, Fujita A, Ishizaki T, Narumiya S
Nat Cell Biol. 1999
PubMed ID: 10559899
Biochemical and crystallographic characterization of a Rho effector domain of the protein serine/threonine kinase N in a complex with RhoA.
Maesaki R, Shimizu T, Ihara K, Kuroda S, Kaibuchi K, Hakoshima T
J Struct Biol. 1999
PubMed ID: 10388627
G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm).
Kiyono M, Satoh T, Kaziro Y
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10220378
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.
Houssa B, de Widt J, Kranenburg O, Moolenaar WH, van Blitterswijk WJ
J Biol Chem. 1999
PubMed ID: 10066731
The small GTPase RalA targets filamin to induce filopodia.
Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10051605
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases.
Ren Y, Li R, Zheng Y, Busch H
J Biol Chem. 1998
PubMed ID: 9857026
Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation.
Missy K, Van Poucke V, Raynal P, Viala C, Mauco G, Plantavid M, Chap H, Payrastre B
J Biol Chem. 1998
PubMed ID: 9804788
Stimulation of phospholipase C-beta2 by the Rho GTPases Cdc42Hs and Rac1.
Illenberger D, Schwald F, Pimmer D, Binder W, Maier G, Dietrich A, Gierschik P
EMBO J. 1998
PubMed ID: 9799233
Localization of RhoA GTPase to endothelial caveolae-enriched membrane domains.
Gingras D, Gauthier F, Lamy S, Desrosiers RR, Béliveau R
Biochem Biophys Res Commun. 1998
PubMed ID: 9647788
The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.
Cachero TG, Morielli AD, Peralta EG
Cell. 1998
PubMed ID: 9635436
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.
Dai Q, Choy E, Chiu V, Romano J, Slivka SR, Steitz SA, Michaelis S, Philips MR
J Biol Chem. 1998
PubMed ID: 9614111
Determination of interaction sites on the small G protein RhoA for phospholipase D.
Bae CD, Min DS, Fleming IN, Exton JH
J Biol Chem. 1998
PubMed ID: 9565577
Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.
Billuart P, Bienvenu T, Ronce N, des Portes V, Vinet MC, Zemni R, Roest Crollius H, Carrié A, Fauchereau F, Cherry M, Briault S, Hamel B, Fryns JP, Beldjord C, Kahn A, Moraine C, Chelly J
Nature. 1998
PubMed ID: 9582072
Crystal structure of human RhoA in a dominantly active form complexed with a GTP analogue.
Ihara K, Muraguchi S, Kato M, Shimizu T, Shirakawa M, Kuroda S, Kaibuchi K, Hakoshima T
J Biol Chem. 1998
PubMed ID: 9545299
Transposition of RhoA to the murine Y chromosome.
Boettger-Tong HL, Agulnik AI, Ty TI, Bishop CE
Genomics. 1998
PubMed ID: 9598304
Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1.
Zhang B, Zheng Y
Biochemistry. 1998
PubMed ID: 9548756
Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.
Zhang B, Chernoff J, Zheng Y
J Biol Chem. 1998
PubMed ID: 9535855
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7.
Alberts AS, Bouquin N, Johnston LH, Treisman R
J Biol Chem. 1998
PubMed ID: 9535835
Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity.
Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P
FEBS Lett. 1998
PubMed ID: 9490022
Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.
Flynn P, Mellor H, Palmer R, Panayotou G, Parker PJ
J Biol Chem. 1998
PubMed ID: 9446575
Rho GTPases and the actin cytoskeleton.
Hall A
Science. 1998
PubMed ID: 9438836
Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190.
Li R, Zhang B, Zheng Y
J Biol Chem. 1997
PubMed ID: 9407060
Regulation of myosin phosphatase through phosphorylation of the myosin-binding subunit in platelet activation.
Nakai K, Suzuki Y, Kihira H, Wada H, Fujioka M, Ito M, Nakano T, Kaibuchi K, Shiku H, Nishikawa M
Blood. 1997
PubMed ID: 9354661
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Crystal structure of RhoA-GDP and its functional implications.
Wei Y, Zhang Y, Derewenda U, Liu X, Minor W, Nakamoto RK, Somlyo AV, Somlyo AP, Derewenda ZS
Nat Struct Biol. 1997
PubMed ID: 9302995
Different functions of the GTPase Rho in prothymocytes and late pre-T cells.
Galandrini R, Henning SW, Cantrell DA
Immunity. 1997
PubMed ID: 9252129
Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology.
Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH
J Cell Biol. 1997
PubMed ID: 9199174
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
Watanabe N, Madaule P, Reid T, Ishizaki T, Watanabe G, Kakizuka A, Saito Y, Nakao K, Jockusch BM, Narumiya S
EMBO J. 1997
PubMed ID: 9214622
RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.
Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9113980
The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.
Vincent S, Settleman J
Mol Cell Biol. 1997
PubMed ID: 9121475
Differential expression of Rho family GTP-binding proteins and protein kinase C isozymes during C6 glial cell differentiation.
Yoshimura S, Sakai H, Nakashima S, Nozawa Y, Shinoda J, Sakai N, Yamada H
Brain Res Mol Brain Res. 1997
PubMed ID: 9105674
Assignment of the ARHA and GPX1 genes to human chromosome bands 3p21.3 by in situ hybridization and with somatic cell hybrids.
Kiss C, Li J, Szeles A, Gizatullin RZ, Kashuba VI, Lushnikova T, Protopopov AI, Kelve M, Kiss H, Kholodnyuk ID, Imreh S, Klein G, Zabarovsky ER
Cytogenet Cell Genet. 1997
PubMed ID: 9605859
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
Quilliam LA, Lambert QT, Mickelson-Young LA, Westwick JK, Sparks AB, Kay BK, Jenkins NA, Gilbert DJ, Copeland NG, Der CJ
J Biol Chem. 1996
PubMed ID: 8910519
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton.
Leung T, Chen XQ, Manser E, Lim L
Mol Cell Biol. 1996
PubMed ID: 8816443
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
Fujisawa K, Fujita A, Ishizaki T, Saito Y, Narumiya S
J Biol Chem. 1996
PubMed ID: 8798490
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor.
Hotta K, Tanaka K, Mino A, Kohno H, Takai Y
Biochem Biophys Res Commun. 1996
PubMed ID: 8769096
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
Reid T, Furuyashiki T, Ishizaki T, Watanabe G, Watanabe N, Fujisawa K, Morii N, Madaule P, Narumiya S
J Biol Chem. 1996
PubMed ID: 8662891
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.
Matsui T, Amano M, Yamamoto T, Chihara K, Nakafuku M, Ito M, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K
EMBO J. 1996
PubMed ID: 8641286
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, Watanabe N, Saito Y, Kakizuka A, Morii N, Narumiya S
EMBO J. 1996
PubMed ID: 8617235
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N.
Amano M, Mukai H, Ono Y, Chihara K, Matsui T, Hamajima Y, Okawa K, Iwamatsu A, Kaibuchi K
Science. 1996
PubMed ID: 8571127
A novel partner for the GTP-bound forms of rho and rac.
Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S
FEBS Lett. 1995
PubMed ID: 8543060
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.
Bokoch GM, Bohl BP, Chuang TH
J Biol Chem. 1994
PubMed ID: 7989340
Sequence of rho small GTP-binding protein cDNAs from human retina and identification of novel 5' end cloning artifacts.
Fagan KP, Oliveira L, Pittler SJ
Exp Eye Res. 1994
PubMed ID: 7835413
Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
Moscow JA, He R, Gudas JM, Cowan KH
Gene. 1994
PubMed ID: 8039707
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
Small GTP-binding proteins and the regulation of the actin cytoskeleton.
Hall A
Annu Rev Cell Biol. 1994
PubMed ID: 7888179
A novel role for RhoGDI as an inhibitor of GAP proteins.
Hancock JF, Hall A
EMBO J. 1993
PubMed ID: 8491184
A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.
Nemoto Y, Namba T, Teru-uchi T, Ushikubi F, Morii N, Narumiya S
J Biol Chem. 1992
PubMed ID: 1328215
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.
Ridley AJ, Hall A
Cell. 1992
PubMed ID: 1643657
Structure and function of the 5'-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1).
Moscow JA, Morrow CS, He R, Mullenbach GT, Cowan KH
J Biol Chem. 1992
PubMed ID: 1556108
Chromosome localization of human ARH genes, a ras-related gene family.
Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K
Genomics. 1990
PubMed ID: 2407642
Nucleotide sequence of human rho cDNA clone 12.
Yeramian P, Chardin P, Madaule P, Tavitian A
Nucleic Acids Res. 1987
PubMed ID: 3822842

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	387	11848	117273
EnsEMBL Gene(s)	ENSG00000067560	ENSMUSG00000007815	ENSRNOG00000012630
Unigene	Hs.247077	Mm.757	Rn.107401
Homologene	RHOA	Rhoa	Rhoa
OMIM	165390	N/A	N/A
GeneCards	RHOA	N/A	N/A
Beta Cell Genomics	DT.100059757 DT.100695864 DT.100695868 DT.100695869 DT.100695874 DT.100695892 DT.120904554 DT.453628 DT.91777425 DT.91777456 DT.91860959 DT.97868367	DT.102545939 DT.94382596 DT.99840870	N/A
Reactome	P61586	N/A	N/A
Plasma Peptide Atlas	ENSP00000285735	N/A	N/A
WikiGenes	387	11848	117273

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
RHOA	CNKSR1	HPRD, MINT, IntAct	empirical	14749388 15670823
RHOA	CDKN1B	MINT	empirical	17581634
RHOA	NET1	BioGRID	empirical	9535835
RHOA	GNB2L1	IntAct	empirical	21988832
RHOA	VAV3	HPRD, BioGRID	empirical	10523675
RHOA	RABAC1	HPRD, IntAct	empirical	11335720
RHOA	CIT	HPRD, BioGRID	empirical	8543060 12773565
RHOA	AKAP13	HPRD, BioGRID	empirical	12423633 11696353
RHOA	RHPN1	HPRD	empirical	12221077
RHOA	ARHGEF25	HPRD, BioGRID	empirical	15069594
RHOA	ARHGEF19	MINT	empirical	18256687
RHOA	CRMP1	BioGRID	empirical	12482610
RHOA	DGKQ	HPRD, BioGRID	empirical	10066731
RHOA	DIAPH1	HPRD, BioGRID	empirical	16109481 15864301 12773565 9535835
RHOA	DVL2	HPRD	empirical	12533515
RHOA	SPRED2	HPRD	empirical	15184877
RHOA	KIN	BioGRID	empirical	9535835
RHOA	DAAM1	HPRD, MINT	empirical	11779461 16630611
RHOA	ARHGAP26	BioGRID	empirical	11432776
RHOA	FLNA	HPRD	empirical	10051605
RHOA	MPRIP	HPRD, BioGRID	empirical	14506264 9199174
RHOA	MCF2L	HPRD, IntAct, BioGRID	empirical	12006984 11889037
RHOA	ARHGEF12	HPRD, IntAct, BioGRID	empirical	11373293 15364580 12515866
RHOA	ARHGEF18	HPRD, BioGRID	empirical	11085924
RHOA	ICMT	HPRD, BioGRID	empirical	9614111
RHOA	SH3BP1	HPRD	empirical	9548756
RHOA	ARHGAP8	HPRD	empirical	12944407
RHOA	NGEF	MINT	empirical	18256687
RHOA	GNA12	BioGRID	empirical	12515866
RHOA	ARHGAP35	BioGRID	empirical	9548756 15102857
RHOA	HLA-B	IntAct	empirical	17353931
RHOA	HSPA1A	HPRD	empirical	12490434
RHOA	APLP2	IntAct	empirical	17934213
RHOA	FAS	BioGRID	empirical	15659383
RHOA	FASLG	BioGRID	empirical	15659383
RHOA	ITPR1	HPRD, BioGRID	empirical	12766172
RHOA	KCNA2	HPRD, MIPS, BioGRID	empirical	9635436
RHOA	KCNMA1	IntAct	empirical	19423573
RHOA	RHOA	HPRD, IntAct, BioGRID	empirical	15069594 20360068
RHOA	KTN1	HPRD, BioGRID	empirical	8769096 11689693 12773565 9535835 11162552
RHOA	ARHGAP1	HPRD, MINT, IntAct, BioGRID	empirical	9548756 16189514 9338791 11927263 9407060 9535855 20660160
RHOA	ARHGAP5	HPRD, BioGRID	empirical	9407060 12842009
RHOA	ARHGDIA	HPRD, IntAct, BioGRID	empirical	10489445 17353931 15659383 11149925 9490022 11368848
RHOA	ARHGDIB	HPRD	empirical	9799233
RHOA	ARHGDIG	HPRD, BioGRID	empirical	9113980
RHOA	RHOH	MINT	empirical	15670823
RHOA	SMAD2	IntAct	empirical	20195357
RHOA	MCF2	HPRD, BioGRID	empirical	10854437
RHOA	MSN	BioGRID	empirical	15659383
RHOA	PPP1R12A	HPRD	empirical	9354661
RHOA	NPHS1	BioGRID	empirical	11562357
RHOA	OPHN1	HPRD, BioGRID	empirical	11998687 9582072
RHOA	DEF6	HPRD, BioGRID	empirical	15023524
RHOA	ARHGEF4	HPRD, BioGRID	empirical	10947987
RHOA	ARHGEF3	HPRD, BioGRID	empirical	12221096
RHOA	GMIP	HPRD	empirical	12093360
RHOA	PDE6D	HPRD, BioGRID	empirical	11786539
RHOA	PLCG1	HPRD, BioGRID	empirical	12071848
RHOA	PLD1	HPRD, BioGRID	empirical	11311142 12593858 9565577
RHOA	PLXNB1	BioGRID	empirical	19805522
RHOA	RIPK4	BioGRID	empirical	9199174
RHOA	OTUB1	BioGRID	empirical	20553488
RHOA	PRKACA	HPRD	empirical	12654918
RHOA	PRKCA	HPRD	empirical	11284700
RHOA	PKN1	HPRD, MINT, IntAct	empirical	9446575 8571127 10619026
RHOA	PKN2	HPRD	empirical	8910519 9121475
RHOA	PRKCZ	HPRD	empirical	15210811
RHOA	MAPK8	BioGRID	empirical	15659383
RHOA	SMURF1	HPRD, MINT, BioGRID	empirical	16472676 15710384 16622418 21708152 21262463
RHOA	SRGAP1	HPRD, BioGRID	empirical	11672528 20856855
RHOA	ARHGAP21	HPRD	empirical	15793564
RHOA	RAC1	MINT, IntAct	empirical	15102471
RHOA	RAP1GDS1	HPRD, BioGRID	empirical	11948427
RHOA	RASGRF1	HPRD, MIPS	empirical	10220378
RHOA	ROCK1	HPRD, IntAct, BioGRID	empirical	8798490 14660612 12773565 9535835 8816443
RHOA	BCR	BioGRID	empirical	9535855
RHOA	RPN2	IntAct	empirical	21988832
RHOA	RTKN	HPRD, MINT, IntAct, BioGRID	empirical	8662891 14506264 16630611 18256687 18854161 21029865 12879077 12593858 19805522
RHOA	BID	BioGRID	empirical	15659383
RHOA	RGNEF	HPRD	empirical	9199174
RHOA	SMURF2	IntAct, BioGRID	empirical	17719543 20026602
RHOA	PLEKHG2	HPRD, BioGRID	empirical	11839748
RHOA	SLC2A4	IntAct	empirical	16396496
RHOA	TGFBR1	HPRD	empirical	15761153
RHOA	TGM2	HPRD	empirical	11350930
RHOA	TNFRSF1A	BioGRID	empirical	15659383
RHOA	TRIO	HPRD, BioGRID	empirical	10948190
RHOA	TRPC1	HPRD, BioGRID	empirical	12766172
RHOA	UBB	IntAct	empirical	17719543
RHOA	UBC	MINT, BioGRID	empirical	15710384 17719543 16622418 20553488 16196087 19782033 21262463 21987572 12938929 21906983
RHOA	VAV1	HPRD, MINT	empirical	16397238 18511940
RHOA	VAV2	HPRD	empirical	11909943
RHOA	EZR	BioGRID	empirical	15659383
RHOA	ARHGAP10	BioGRID	empirical	11432776
RHOA	ARHGEF5	IntAct	empirical	12006984
RHOA	DIAPH3	BioGRID	empirical	9535835
RHOA	CASP8	BioGRID	empirical	15659383
RHOA	CASP10	BioGRID	empirical	15659383
RHOA	CUL3	BioGRID	empirical	19782033
RHOA	CNTNAP1	HPRD, BioGRID	empirical	9407060 9535855
RHOA	ITGA8	MINT	empirical	17300786
RHOA	RHPN2	HPRD, BioGRID	empirical	12221077 12773565
RHOA	DOCK7	HPRD	empirical	12432077
RHOA	CAV1	HPRD, MIPS, BioGRID	empirical	9647788 20460433
RHOA	CBS	Sanger Interaction Map	predicted	15345047
RHOA	FADD	BioGRID	empirical	15659383
RHOA	TNFRSF10B	BioGRID	empirical	15659383
RHOA	ARHGEF1	BioGRID	empirical	12748184
RHOA	ARHGEF2	HPRD, BioGRID	empirical	9857026
RHOA	ROCK2	BioGRID	empirical	11350930
RHOA	PITPNM1	HPRD	empirical	15125835
RHOA	ARHGAP32	BioGRID	empirical	12857875 12446789 12454018
RHOA	FAM65B	IntAct	empirical	21988832
RHOA	ARHGEF11	HPRD, IntAct, BioGRID	empirical	10526156 15530360 21988832