Home KRAS
|
Regions Overlapping this Feature:
Mouse: 1
Linkage Regions: 1 Available
Linkage Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes | Linkage and Congenic Studies |
|---|---|---|---|---|---|
| Idd6.2 | Mouse | chr6:137388269..146377508 | 8.99 | 55 |
(Human) GRCh37 - chr12:25357723..25403870 (46.15 kb) View in Genome Browser
(Mouse) NCBIM37 - chr6:145165219..145198759 (33.54 kb) View in Genome Browser
(Rat) RGSC3.4 - chr4:182868739..182895119 (26.38 kb) View in Genome Browser
HaemAtlas Expression Table for KRAS:|
Expression Legend
|
|
|
Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Expression Legend
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for KRAS:The KRAS interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| KRAS | CDK2 | BioGRID | empirical | 22045811 |
| KRAS | CCT7 | BioGRID | empirical | 21900206 |
| KRAS | ADH6 | IntAct | empirical | 21988832 |
| KRAS | LPAR1 | IntAct | empirical | 21988832 |
| KRAS | EEF1A1 | BioGRID | empirical | 21900206 |
| KRAS | EPB42 | HPRD, BioGRID | empirical | 3276554 |
| KRAS | FNTA | HPRD, IntAct | empirical | 12374986 15451670 |
| KRAS | FNTB | HPRD | empirical | 12374986 |
| KRAS | HNRNPC | HPRD, IntAct | empirical | 16189514 |
| KRAS | ARAF | MINT, IntAct | empirical | 15102471 |
| KRAS | DDX47 | IntAct | empirical | 21988832 |
| KRAS | PGGT1B | HPRD | empirical | 15451670 |
| KRAS | PIK3CA | BioGRID | empirical | 10783161 |
| KRAS | PIK3CG | HPRD, BioGRID | empirical | 10542052 |
| KRAS | PIK3R2 | IntAct | empirical | 21988832 |
| KRAS | APBB1IP | MINT | empirical | 15642358 |
| KRAS | EGLN1 | IntAct | empirical | 21988832 |
| KRAS | RGL2 | MINT, IntAct | empirical | 21988832 15102471 |
| KRAS | RAF1 | HPRD, MINT, IntAct, BioGRID | empirical | 9446616 20802526 17229891 15102471 10783161 10882715 |
| KRAS | RALGDS | HPRD, IntAct, BioGRID, Sanger Interaction Map | empirical | 7809086 21988832 10783161 15345047 |
| KRAS | RAP1GDS1 | HPRD, BioGRID | empirical | 11948427 |
| KRAS | RASGRF2 | BioGRID | empirical | 11238945 |
| KRAS | BCL2 | HPRD | empirical | 10490827 |
| KRAS | SKP2 | BioGRID | empirical | 19533683 |
| KRAS | BRAF | MINT, IntAct, Sanger Interaction Map | empirical | 15102471 15345047 |
| KRAS | UBC | BioGRID | empirical | 19533683 21139048 21890473 21906983 |
| KRAS | DDX50 | IntAct | empirical | 21988832 |
| KRAS | CALM1 | HPRD | empirical | 12727204 11585916 |
| KRAS | SHOC2 | HPRD, BioGRID, Sanger Interaction Map | empirical | 9674433 10783161 15345047 |
| KRAS | RASSF5 | HPRD, IntAct | empirical | 11857081 |
| KRAS | IGSF21 | BioGRID | empirical | 21900206 |
| KRAS | DNAJA3 | BioGRID | empirical | 18624398 |
| KRAS | PDE4DIP | BioGRID | empirical | 21900206 |
| KRAS | FRMPD4 | Sanger Interaction Map | predicted | 15345047 |
| KRAS | RASSF2 | HPRD, IntAct, BioGRID | empirical | 12732644 |
| KRAS | CDC20 | BioGRID | empirical | 22045811 |
| KRAS | CDC27 | BioGRID | empirical | 22045811 |
|
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
|
|
Type 1 Diabetes Publications: 4
-
The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.
Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I
J Pathol. 2009
PubMed ID: 19585519
-
Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.
Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewsky B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L
PLoS Genet. 2009
PubMed ID: 19629168
-
Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia.
Seeley ES, Carrière C, Goetze T, Longnecker DS, Korc M
Cancer Res. 2009
PubMed ID: 19147554
-
Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice.
Habbe N, Shi G, Meguid RA, Fendrich V, Esni F, Chen H, Feldmann G, Stoffers DA, Konieczny SF, Leach SD, Maitra A
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19028870
Publications: 1303
-
Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice.
Lee CL, Moding EJ, Huang X, Li Y, Woodlief LZ, Rodrigues RC, Ma Y, Kirsch DG
Dis Model Mech. 2012
PubMed ID: 22228755
-
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.
Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ
Cancer Cell. 2012
PubMed ID: 22264792
-
MEK1/2 dual-specificity protein kinases: structure and regulation.
Roskoski R
Biochem Biophys Res Commun. 2012
PubMed ID: 22177953
-
MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol.
Han Z, Yang Q, Liu B, Wu J, Li Y, Yang C, Jiang Y
Carcinogenesis. 2012
PubMed ID: 22016468
-
EGFR and KRAS mutations and altered c-Met gene copy numbers in primary non-small cell lung cancer and associated stage N2 lymph node-metastasis.
Han CB, Ma JT, Li F, Zhao JZ, Jing W, Zhou Y, Zou HW
Cancer Lett. 2012
PubMed ID: 21982684
-
EGFR and KRAS mutations detection on lung cancer liquid-based cytology: a pilot study.
Malapelle U, de Rosa N, Rocco D, Bellevicine C, Crispino C, Illiano A, Piantedosi FV, Nappi O, Troncone G
J Clin Pathol. 2012
PubMed ID: 21945923
-
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
Matallanas D, Romano D, Al-Mulla F, O'Neill E, Al-Ali W, Crespo P, Doyle B, Nixon C, Sansom O, Drosten M, Barbacid M, Kolch W
Mol Cell. 2011
PubMed ID: 22195963
-
Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
Yamada K, Tamamori-Adachi M, Goto I, Iizuka M, Yasukawa T, Aso T, Okazaki T, Kitajima S
J Biol Chem. 2011
PubMed ID: 22045811
-
Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma.
Olson P, Chu GC, Perry SR, Nolan-Stevaux O, Hanahan D
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22084065
-
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
Schulten HJ, Al-Maghrabi J, Al-Ghamdi K, Salama S, Al-Muhayawi S, Chaudhary A, Hamour O, Abuzenadah A, Gari M, Al-Qahtani M
Anticancer Res. 2011
PubMed ID: 22199277
-
Identification of tumorigenic cells in Kras(G12D)-induced lung adenocarcinoma.
Cho HC, Lai CY, Shao LE, Yu J
Cancer Res. 2011
PubMed ID: 22088965
-
β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
Clark PE, Polosukhina D, Love H, Correa H, Coffin C, Perlman EJ, de Caestecker M, Moses HL, Zent R
Am J Pathol. 2011
PubMed ID: 21983638
-
Multiple stress signals activate mutant p53 in vivo.
Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G
Cancer Res. 2011
PubMed ID: 21983037
-
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Acin S, Li Z, Mejia O, Roop DR, El-Naggar AK, Caulin C
J Pathol. 2011
PubMed ID: 21952947
-
Detection of KRAS gene mutations in endoscopic ultrasound-guided fine-needle aspiration biopsy for improving pancreatic cancer diagnosis.
Wang X, Gao J, Ren Y, Gu J, Du Y, Chen J, Jin Z, Zhan X, Li Z, Huang H, Lv S, Gong Y
Am J Gastroenterol. 2011
PubMed ID: 21876563
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L
Nature. 2011
PubMed ID: 22080947
-
Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS.
Wade R, Brimer N, Lyons C, Vande Pol S
J Biol Chem. 2011
PubMed ID: 21900245
-
Molecular morphometric analysis shows relative intra-tumoural homogeneity for KRAS mutations in colorectal cancer.
Farber L, Efrati E, Elkin H, Peerless Y, Sabo E, Ben-Izhak O, Hershkovitz D
Virchows Arch. 2011
PubMed ID: 22016105
-
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Gao Q, Steine EJ, Barrasa MI, Hockemeyer D, Pawlak M, Fu D, Reddy S, Bell GW, Jaenisch R
Proc Natl Acad Sci U S A. 2011
PubMed ID: 22011581
-
EGFR mutations, gene amplification, and protein expression and KRAS mutations in primary and metastatic tumors of nonsmall cell lung cancers and their clinical implications: a meta-analysis.
Han C, Ma J, Zhao J, Zhou Y, Jing W, Zou H
Cancer Invest. 2011
PubMed ID: 22011285
-
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers.
Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Wong KK, Cantley LC, Engelman JA
J Clin Invest. 2011
PubMed ID: 21985784
-
SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.
Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO
J Clin Invest. 2011
PubMed ID: 21965329
-
Progression of human bronchioloalveolar carcinoma to invasive adenocarcinoma is modeled in a transgenic mouse model of K-ras-induced lung cancer by loss of the TGF-β type II receptor.
Borczuk AC, Sole M, Lu P, Chen J, Wilgus ML, Friedman RA, Albelda SM, Powell CA
Cancer Res. 2011
PubMed ID: 21911454
-
Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression.
Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, Goldsmith EJ, Tournier C, Kurie JM
Mol Cell Biol. 2011
PubMed ID: 21896780
-
Tumor-infiltrating lymphocytes and dendritic cells in human colorectal cancer: their relationship to KRAS mutational status and disease recurrence.
Kocián P, Šedivcová M, Drgáč J, Cerná K, Hoch J, Kodet R, Bartůňková J, Špíšek R, Fialová A
Hum Immunol. 2011
PubMed ID: 21884745
-
Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice.
Bai H, Li H, Zhang W, Matkowskyj KA, Liao J, Srivastava SK, Yang GY
Carcinogenesis. 2011
PubMed ID: 21859833
-
Multigene mutation analysis of metastatic lymph nodes in non-small cell lung cancer diagnosed by endobronchial ultrasound-guided transbronchial needle aspiration.
Nakajima T, Yasufuku K, Nakagawara A, Kimura H, Yoshino I
Chest. 2011
PubMed ID: 21527506
-
Preoperative chemoradiation with cetuximab, irinotecan, and capecitabine in patients with locally advanced resectable rectal cancer: a multicenter Phase II study.
Kim SY, Hong YS, Kim DY, Kim TW, Kim JH, Im SA, Lee KS, Yun T, Jeong SY, Choi HS, Lim SB, Chang HJ, Jung KH
Int J Radiat Oncol Biol Phys. 2011
PubMed ID: 20888703
-
EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy.
Thunnissen E, Bovée JV, Bruinsma H, van den Brule AJ, Dinjens W, Heideman DA, Meulemans E, Nederlof P, van Noesel C, Prinsen CF, Scheidel K, van de Ven PM, de Weger R, Schuuring E, Ligtenberg M
J Clin Pathol. 2011
PubMed ID: 21947301
-
Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.
Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL
J Clin Invest. 2011
PubMed ID: 21926469
-
Clinical characterization of patients with metastatic colorectal cancer depending on the KRAS status.
Modest DP, Stintzing S, Laubender RP, Neumann J, Jung A, Giessen C, Haas M, Aubele P, Schulz C, Boeck S, Stemmler HJ, Kirchner T, Heinemann V
Anticancer Drugs. 2011
PubMed ID: 21795973
-
Fluorescence in situ hybridization and K-ras analyses improve diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses.
Reicher S, Boyar FZ, Albitar M, Sulcova V, Agersborg S, Nga V, Zhou Y, Li G, Venegas R, French SW, Chung DS, Stabile BE, Eysselein VE, Anguiano A
Pancreas. 2011
PubMed ID: 21705950
-
Multiple mutations in the Kras gene in colorectal cancer: review of the literature with two case reports.
Macedo MP, Andrade Lde B, Coudry R, Crespo R, Gomes M, Lisboa BC, Aguiar S, Soares FA, Carraro DM, Cunha IW
Int J Colorectal Dis. 2011
PubMed ID: 21603900
-
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Oltedal S, Aasprong OG, Møller JH, Kørner H, Gilje B, Tjensvoll K, Birkemeyer EM, Heikkilä R, Smaaland R, Nordgård O
Int J Colorectal Dis. 2011
PubMed ID: 21573767
-
EGFR and KRAS mutations in metastatic lung adenocarcinomas.
Munfus-McCray D, Harada S, Adams C, Askin F, Clark D, Gabrielson E, Li QK
Hum Pathol. 2011
PubMed ID: 21497370
-
Frequency and clinicopathologic correlates of KRAS amplification in non-small cell lung carcinoma.
Wagner PL, Stiedl AC, Wilbertz T, Petersen K, Scheble V, Menon R, Reischl M, Mikut R, Rubin MA, Fend F, Moch H, Soltermann A, Weder W, Altorki NK, Perner S
Lung Cancer. 2011
PubMed ID: 21477882
-
Nitrative and oxidative DNA damage caused by K-ras mutation in mice.
Ohnishi S, Saito H, Suzuki N, Ma N, Hiraku Y, Murata M, Kawanishi S
Biochem Biophys Res Commun. 2011
PubMed ID: 21875576
-
Clinicopathological features of lung adenocarcinoma with KRAS mutations.
Kakegawa S, Shimizu K, Sugano M, Miyamae Y, Kaira K, Araki T, Nakano T, Kamiyoshihara M, Kawashima O, Takeyoshi I
Cancer. 2011
PubMed ID: 21387273
-
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K
Cancer Cell. 2011
PubMed ID: 21907929
-
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
-
APC and KRAS mutations in distal colorectal polyps are related to smoking habits in men: results of a cross-sectional study.
Martínez F, Fernández-Martos C, Quintana MJ, Castells A, Llombart A, Ińiguez F, Guillem V, Dasí F
Clin Transl Oncol. 2011
PubMed ID: 21865138
-
An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer.
Cohn AL, Shumaker GC, Khandelwal P, Smith DA, Neubauer MA, Mehta N, Richards D, Watkins DL, Zhang K, Yassine MR
Clin Colorectal Cancer. 2011
PubMed ID: 21855038
-
Does neoadjuvant therapy alter KRAS and/or MSI results in rectal adenocarcinoma testing?
Ondrejka SL, Schaeffer DF, Jakubowski MA, Owen DA, Bronner MP
Am J Surg Pathol. 2011
PubMed ID: 21836482
-
Heterogeneity of KRAS status may explain the subset of discordant KRAS status between primary and metastatic colorectal cancer.
Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Shibuya H, Eshima K
Dis Colon Rectum. 2011
PubMed ID: 21825899
-
STK33 kinase activity is nonessential in KRAS-dependent cancer cells.
Babij C, Zhang Y, Kurzeja RJ, Munzli A, Shehabeldin A, Fernando M, Quon K, Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F, Jackson A, Zondlo J, Sun Y, Ellison AR, Plewa CA, San MT, Robinson J, McCarter J, Schwandner R, Judd T, Carnahan J, Dussault I
Cancer Res. 2011
PubMed ID: 21742770
-
Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions.
Carrière C, Gore AJ, Norris AM, Gunn JR, Young AL, Longnecker DS, Korc M
Gastroenterology. 2011
PubMed ID: 21699781
-
Mutant KRAS promotes hyperplasia and alters differentiation in the colon epithelium but does not expand the presumptive stem cell pool.
Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER
Gastroenterology. 2011
PubMed ID: 21699772
-
Stromal cells do not share KRAS mutations that the epithelial component harbors in colorectal carcinomas.
Baloglu H, Yigit N
Cancer Lett. 2011
PubMed ID: 21624768
-
Differential gene expression signatures between colorectal cancers with and without KRAS mutations: crosstalk between the KRAS pathway and other signalling pathways.
Watanabe T, Kobunai T, Yamamoto Y, Matsuda K, Ishihara S, Nozawa K, Iinuma H, Ikeuchi H, Eshima K
Eur J Cancer. 2011
PubMed ID: 21531130
-
ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.
Luk PP, Galettis P, Links M
Lung Cancer. 2011
PubMed ID: 21277645
-
Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.
Zhang JS, Koenig A, Harrison A, Ugolkov AV, Fernandez-Zapico ME, Couch FJ, Billadeau DD
Oncogene. 2011
PubMed ID: 21441955
-
Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.
Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS
Oncogene. 2011
PubMed ID: 21423204
-
Comparison of methodologies for KRAS mutation detection in metastatic colorectal cancer.
Pinto P, Rocha P, Veiga I, Guedes J, Pinheiro M, Peixoto A, Pinto C, Fragoso M, Sanches E, Araújo A, Alves F, Coutinho C, Lopes P, Henrique R, Teixeira MR
Cancer Genet. 2011
PubMed ID: 21962894
-
A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations.
Riely GJ, Johnson ML, Medina C, Rizvi NA, Miller VA, Kris MG, Pietanza MC, Azzoli CG, Krug LM, Pao W, Ginsberg MS
J Thorac Oncol. 2011
PubMed ID: 21847063
-
Inhibition of miR-193a expression by Max and RXRα activates K-Ras and PLAU to mediate distinct aspects of cellular transformation.
Iliopoulos D, Rotem A, Struhl K
Cancer Res. 2011
PubMed ID: 21670079
-
In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer.
Kinross KM, Brown DV, Kleinschmidt M, Jackson S, Christensen J, Cullinane C, Hicks RJ, Johnstone RW, McArthur GA
Mol Cancer Ther. 2011
PubMed ID: 21632463
-
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
Hollander MC, Zhou X, Maier CR, Patterson AD, Ding X, Dennis PA
Carcinogenesis. 2011
PubMed ID: 21625009
-
KRAS-mutation positive, metastatic tonsil carcinoma with cancer stem-like cell features and long-term response to gefitinib: a case report and review of the literature.
Gottschling S, Penzel R, Pelz T, Herpel E, Schnabel PA, Dyckhoff G, Thomas M, Kuhnt T
J Clin Oncol. 2011
PubMed ID: 21555681
-
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape.
Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR
Science. 2011
PubMed ID: 21764747
-
Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.
Molinari F, Felicioni L, Buscarino M, De Dosso S, Buttitta F, Malatesta S, Movilia A, Luoni M, Boldorini R, Alabiso O, Girlando S, Soini B, Spitale A, Di Nicolantonio F, Saletti P, Crippa S, Mazzucchelli L, Marchetti A, Bardelli A, Frattini M
Clin Cancer Res. 2011
PubMed ID: 21632860
-
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.
Corcoran RB, Contino G, Deshpande V, Tzatsos A, Conrad C, Benes CH, Levy DE, Settleman J, Engelman JA, Bardeesy N
Cancer Res. 2011
PubMed ID: 21586612
-
Id3 modulates cellular localization of bHLH Ptf1-p48 protein.
Dufresne M, Clerc P, Dieng M, Edir A, Couvelard A, Delisle MB, Fourmy D, Gigoux V
Int J Cancer. 2011
PubMed ID: 20830706
-
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.
Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T
Mol Cell. 2011
PubMed ID: 21726810
-
TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression.
Seux M, Peuget S, Montero MP, Siret C, Rigot V, Clerc P, Gigoux V, Pellegrino E, Pouyet L, N'Guessan P, Garcia S, Dufresne M, Iovanna JL, Carrier A, André F, Dusetti NJ
Oncogene. 2011
PubMed ID: 21339733
-
KRAS-mediated up-regulation of RRM2 expression is essential for the proliferation of colorectal cancer cell lines.
Yoshida Y, Tsunoda T, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Takashima Y, Sasazuki T, Kuroki M, Iwasaki A, Shirasawa S
Anticancer Res. 2011
PubMed ID: 21873171
-
Oncogenic KRAS regulates miR-200c and miR-221/222 in a 3D-specific manner in colorectal cancer cells.
Tsunoda T, Takashima Y, Yoshida Y, Doi K, Tanaka Y, Fujimoto T, Machida T, Ota T, Koyanagi M, Kuroki M, Sasazuki T, Shirasawa S
Anticancer Res. 2011
PubMed ID: 21873159
-
Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration.
Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X
Mol Cell Biol. 2011
PubMed ID: 21576358
-
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Luo F, Poulogiannis G, Ye H, Hamoudi R, Arends MJ
Oncol Rep. 2011
PubMed ID: 21573497
-
Pancreatic ductal adenocarcinoma mice lacking mucin 1 have a profound defect in tumor growth and metastasis.
Besmer DM, Curry JM, Roy LD, Tinder TL, Sahraei M, Schettini J, Hwang SI, Lee YY, Gendler SJ, Mukherjee P
Cancer Res. 2011
PubMed ID: 21558393
-
Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development.
Qu X, Hertzler K, Pan Y, Grobe K, Robinson ML, Zhang X
Dev Biol. 2011
PubMed ID: 21536023
-
K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
Ahmad I, Singh LB, Foth M, Morris CA, Taketo MM, Wu XR, Leung HY, Sansom OJ, Iwata T
Dis Model Mech. 2011
PubMed ID: 21504907
-
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Schimanski CC, Moehler M, Gockel I, Zimmermann T, Lang H, Galle PR, Berger MR
J Cancer Res Clin Oncol. 2011
PubMed ID: 21468700
-
Clinicopathological and molecular features of colorectal serrated neoplasias with different mucosal crypt patterns.
Yano Y, Konishi K, Yamochi T, Katagiri A, Nozawa H, Suzuki H, Toyota M, Kubota Y, Muramoto T, Kobayashi Y, Tojo M, Konda K, Makino R, Kaneko K, Yoshikawa N, Ota H, Imawari M
Am J Gastroenterol. 2011
PubMed ID: 21427714
-
Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study.
Bokemeyer C, Bondarenko I, Hartmann JT, de Braud F, Schuch G, Zubel A, Celik I, Schlichting M, Koralewski P
Ann Oncol. 2011
PubMed ID: 21228335
-
p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation.
Laptenko O, Beckerman R, Freulich E, Prives C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21606339
-
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.
Serres MP, Zlotek-Zlotkiewicz E, Concha C, Gurian-West M, Daburon V, Roberts JM, Besson A
Oncogene. 2011
PubMed ID: 21317921
-
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernández-Porras I, Cañamero M, Rodriguez-Justo M, Serrano M, Barbacid M
Cancer Cell. 2011
PubMed ID: 21665147
-
In vivo diagnosis of murine pancreatic intraepithelial neoplasia and early-stage pancreatic cancer by molecular imaging.
Eser S, Messer M, Eser P, von Werder A, Seidler B, Bajbouj M, Vogelmann R, Meining A, von Burstin J, Algül H, Pagel P, Schnieke AE, Esposito I, Schmid RM, Schneider G, Saur D
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21628592
-
Estimating preclinical efficacy targets utilizing cetuximab efficacy in KRAS mutant and wild-type colorectal cancer models.
Prewett M, Bassi R, Paz K, Amatulli M, Deevi D, Li H, Wang S, Witte L, Samakoglu S, Tonra JR
Anticancer Res. 2011
PubMed ID: 21737635
-
[Study on point mutations of K-ras gene in non-small cell lung cancer in Guangxi].
Zhong W, Chen M, Xian L, Li M
Zhongguo Fei Ai Za Zhi. 2011
PubMed ID: 21645454
-
Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models.
Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E
Cancer Prev Res (Phila). 2011
PubMed ID: 21636548
-
A systematic review and meta-analysis of KRAS status as the determinant of response to anti-EGFR antibodies and the impact of partner chemotherapy in metastatic colorectal cancer.
Adelstein BA, Dobbins TA, Harris CA, Marschner IC, Ward RL
Eur J Cancer. 2011
PubMed ID: 21550229
-
MicroRNA signatures differentiate melanoma subtypes.
Chan E, Patel R, Nallur S, Ratner E, Bacchiocchi A, Hoyt K, Szpakowski S, Godshalk S, Ariyan S, Sznol M, Halaban R, Krauthammer M, Tuck D, Slack FJ, Weidhaas JB
Cell Cycle. 2011
PubMed ID: 21543894
-
Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse.
Charles RP, Iezza G, Amendola E, Dankort D, McMahon M
Cancer Res. 2011
PubMed ID: 21512141
-
Uncoupling cancer mutations reveals critical timing of p53 loss in sarcomagenesis.
Young NP, Crowley D, Jacks T
Cancer Res. 2011
PubMed ID: 21512139
-
Activation of mutated K-ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis.
Cheng CW, Licence D, Cook E, Luo F, Arends MJ, Smith SK, Print CG, Charnock-Jones DS
J Pathol. 2011
PubMed ID: 21480232
-
KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer.
Li HT, Lu YY, An YX, Wang X, Zhao QC
Oncol Rep. 2011
PubMed ID: 21424126
-
The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testing.
Pharoah PD, Palmieri RT, Ramus SJ, Gayther SA, Andrulis IL, Anton-Culver H, Antonenkova N, Antoniou AC, Goldgar D, BCFR Investigators, Beattie MS, Beckmann MW, Birrer MJ, Bogdanova N, Bolton KL, Brewster W, Brooks-Wilson A, Brown R, Butzow R, Caldes T, Caligo MA, Campbell I, Chang-Claude J, Chen YA, Cook LS, Couch FJ, Cramer DW, Cunningham JM, Despierre E, Doherty JA, Dörk T, Dürst M, Eccles DM, Ekici AB, Easton D, EMBRACE Investigators, Fasching PA, de Fazio A, Fenstermacher DA, Flanagan JM, Fridley BL, Friedman E, Gao B, Sinilnikova O, GEMO Study Collaborators, Gentry-Maharaj A, Godwin AK, Goode EL, Goodman MT, Gross J, Hansen TV, Harnett P, Rookus M, HEBON Investigators, Heikkinen T, Hein R, Høgdall C, Høgdall E, Iversen ES, Jakubowska A, Johnatty SE, Karlan BY, Kauff ND, Kaye SB, Chenevix-Trench G, kConFab Investigators and the Consortium of Investigators of Modifiers of BRCA1/2, Kelemen LE, Kiemeney LA, Kjaer SK, Lambrechts D, Lapolla JP, Lázaro C, Le ND, Leminen A, Leunen K, Levine DA, Lu Y, Lundvall L, Macgregor S, Marees T, Massuger LF, McLaughlin JR, Menon U, Montagna M, Moysich KB, Narod SA, Nathanson KL, Nedergaard L, Ness RB, Nevanlinna H, Nickels S, Osorio A, Paul J, Pearce CL, Phelan CM, Pike MC, Radice P, Rossing MA, Schildkraut JM, Sellers TA, Singer CF, Song H, Stram DO, Sutphen R, Lindblom A, SWE-BRCA Investigators, Terry KL, Tsai YY, van Altena AM, Vergote I, Vierkant RA, Vitonis AF, Walsh C, Wang-Gohrke S, Wappenschmidt B, Wu AH, Ziogas A, Berchuck A, Risch HA, Ovarian Cancer Association Consortium
Clin Cancer Res. 2011
PubMed ID: 21385923
-
A novel polymorphism in codon 25 of the KRAS gene associated with gallbladder carcinoma patients of the eastern part of India.
Pramanik V, Sarkar BN, Kar M, Das G, Malay BK, Sufia KK, Lakkakula BV, Vadlamudi RR
Genet Test Mol Biomarkers. 2011
PubMed ID: 21375404
-
Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.
Shaw AT, Winslow MM, Magendantz M, Ouyang C, Dowdle J, Subramanian A, Lewis TA, Maglathin RL, Tolliday N, Jacks T
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555567
-
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M
Cancer Cell. 2011
PubMed ID: 21514245
-
Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.
Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, Kenzelmann Broz D, Basak S, Park EJ, McLaughlin ME, Karnezis AN, Attardi LD
Cell. 2011
PubMed ID: 21565614
-
Primer extension reactions as a tool to uncover folding motifs within complex G-rich sequences: analysis of the human KRAS NHE.
Paramasivam M, Cogoi S, Xodo LE
Chem Commun (Camb). 2011
PubMed ID: 21424008
-
Suppression of lung adenocarcinoma progression by Nkx2-1.
Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T
Nature. 2011
PubMed ID: 21471965
-
Oncogenic Ras/Src cooperativity in pancreatic neoplasia.
Shields DJ, Murphy EA, Desgrosellier JS, Mielgo A, Lau SK, Barnes LA, Lesperance J, Huang M, Schmedt C, Tarin D, Lowy AM, Cheresh DA
Oncogene. 2011
PubMed ID: 21242978
-
Defining the origins of Ras/p53-mediated squamous cell carcinoma.
White AC, Tran K, Khuu J, Dang C, Cui Y, Binder SW, Lowry WE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21502519
-
Identifying the cellular origin of squamous skin tumors.
Lapouge G, Youssef KK, Vokaer B, Achouri Y, Michaux C, Sotiropoulou PA, Blanpain C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21502497
-
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium.
Pacheco-Pinedo EC, Durham AC, Stewart KM, Goss AM, Lu MM, Demayo FJ, Morrisey EE
J Clin Invest. 2011
PubMed ID: 21490395
-
[Identification of K-RAS mutations in colorectal cancer patients in Israel].
Segal G, Liebermann N, Klang S, Siegelmann-Daniel N, Beit-Or A, Klien B, Shoushan-Gutman L
Harefuah. 2011
PubMed ID: 21678640
-
Correlation of polypoid colorectal adenocarcinoma with pre-existing adenomatous polyps and KRAS mutation.
Chen H, Lefferts JA, Schwab MC, Suriawinata AA, Tsongalis GJ
Cancer Genet. 2011
PubMed ID: 21665177
-
Adenosquamous carcinoma of the lung: a microdissection study of KRAS and EGFR mutational and amplification status in a western patient population.
Tochigi N, Dacic S, Nikiforova M, Cieply KM, Yousem SA
Am J Clin Pathol. 2011
PubMed ID: 21502435
-
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
Rao B, Gao Y, Huang J, Gao X, Fu X, Huang M, Yao J, Wang J, Li W, Zhang J, Liu H, Wang L, Wang J
Int J Colorectal Dis. 2011
PubMed ID: 21404058
-
Synergistic effect between erlotinib and MEK inhibitors in KRAS wild-type human pancreatic cancer cells.
Diep CH, Munoz RM, Choudhary A, Von Hoff DD, Han H
Clin Cancer Res. 2011
PubMed ID: 21385921
-
Acute sensitivity of the oral mucosa to oncogenic K-ras.
van der Weyden L, Alcolea MP, Jones PH, Rust AG, Arends MJ, Adams DJ
J Pathol. 2011
PubMed ID: 21381032
-
Activated K-Ras protein accelerates human MLL/AF4-induced leukemo-lymphomogenicity in a transgenic mouse model.
Tamai H, Miyake K, Takatori M, Miyake N, Yamaguchi H, Dan K, Shimada T, Inokuchi K
Leukemia. 2011
PubMed ID: 21311557
-
Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.
Vaughn CP, Zobell SD, Furtado LV, Baker CL, Samowitz WS
Genes Chromosomes Cancer. 2011
PubMed ID: 21305640
-
The inv(3)(q21q26)/t(3;3)(q21;q26) is frequently accompanied by alterations of the RUNX1, KRAS and NRAS and NF1 genes and mediates adverse prognosis both in MDS and in AML: a study in 39 cases of MDS or AML.
Haferlach C, Bacher U, Haferlach T, Dicker F, Alpermann T, Kern W, Schnittger S
Leukemia. 2011
PubMed ID: 21283084
-
Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis.
Zhang H, Wang X, Ma Q, Zhou Z, Fang J
Lab Invest. 2011
PubMed ID: 21242956
-
Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells.
Chan G, Cheung LS, Yang W, Milyavsky M, Sanders AD, Gu S, Hong WX, Liu AX, Wang X, Barbara M, Sharma T, Gavin J, Kutok JL, Iscove NN, Shannon KM, Dick JE, Neel BG, Braun BS
Blood. 2011
PubMed ID: 21398220
-
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation.
Kim MJ, Woo SJ, Yoon CH, Lee JS, An S, Choi YH, Hwang SG, Yoon G, Lee SJ
J Biol Chem. 2011
PubMed ID: 21300795
-
Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.
Tang X, Kadara H, Behrens C, Liu DD, Xiao Y, Rice D, Gazdar AF, Fujimoto J, Moran C, Varella-Garcia M, Lee JJ, Hong WK, Wistuba II
Clin Cancer Res. 2011
PubMed ID: 21257719
-
Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
Hollander MC, Maier CR, Hobbs EA, Ashmore AR, Linnoila RI, Dennis PA
Oncogene. 2011
PubMed ID: 21242979
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H
Cancer Cell. 2011
PubMed ID: 21481788
-
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression.
Fukuda A, Wang SC, Morris JP, Folias AE, Liou A, Kim GE, Akira S, Boucher KM, Firpo MA, Mulvihill SJ, Hebrok M
Cancer Cell. 2011
PubMed ID: 21481787
-
[Clinical significance and the handling of KRAS testing on metastatic colorectal cancer].
Kawamoto Y, Yoshino T
Nihon Rinsho. 2011
PubMed ID: 22213982
-
Combined KRAS and TP53 mutation status is not predictive in CAPOX-treated metastatic colorectal cancer.
De Bruijn MT, Raats DA, Tol J, Hinrichs J, Teerenstra S, Punt CJ, Rinkes IH, Kranenburg O
Anticancer Res. 2011
PubMed ID: 21508389
-
A rapid and scalable system for studying gene function in mice using conditional RNA interference.
Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW
Cell. 2011
PubMed ID: 21458673
-
Frequent mutations of KRAS in addition to BRAF in colorectal serrated adenocarcinoma.
Stefanius K, Ylitalo L, Tuomisto A, Kuivila R, Kantola T, Sirniö P, Karttunen TJ, Mäkinen MJ
Histopathology. 2011
PubMed ID: 21457162
-
Clinically important molecular features of Peruvian colorectal tumours: high prevalence of DNA mismatch repair deficiency and low incidence of KRAS mutations.
Egoavil CM, Montenegro P, Soto JL, Casanova L, Sanchez-Lihon J, Castillejo MI, Martinez-Canto A, Perez-Carbonell L, Castillejo A, Guarinos C, Barbera VM, Jover R, Paya A, Alenda C
Pathology. 2011
PubMed ID: 21436632
-
A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis.
Paranjape T, Heneghan H, Lindner R, Keane FK, Hoffman A, Hollestelle A, Dorairaj J, Geyda K, Pelletier C, Nallur S, Martens JW, Hooning MJ, Kerin M, Zelterman D, Zhu Y, Tuck D, Harris L, Miller N, Slack F, Weidhaas J
Lancet Oncol. 2011
PubMed ID: 21435948
-
The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice.
Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, Alvarez CA, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JM
J Clin Invest. 2011
PubMed ID: 21403400
-
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer.
Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, Richman S, Chambers P, Seymour M, Kerr D, Gray R, Quirke P
J Clin Oncol. 2011
PubMed ID: 21383284
-
Context dependence of checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumor suppressor.
Hattori H, Skoulidis F, Russell P, Venkitaraman AR
Mol Cancer Ther. 2011
PubMed ID: 21289082
-
Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.
Cellurale C, Sabio G, Kennedy NJ, Das M, Barlow M, Sandy P, Jacks T, Davis RJ
Mol Cell Biol. 2011
PubMed ID: 21282468
-
KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib.
Kurtze I, Sonnemann J, Beck JF
Oncol Rep. 2011
PubMed ID: 21271222
-
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
Xu D, Allsop SA, Witherspoon SM, Snider JL, Yeh JJ, Fiordalisi JJ, White CD, Williams D, Cox AD, Baines AT
Carcinogenesis. 2011
PubMed ID: 21262926
-
Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice.
Rowley M, Ohashi A, Mondal G, Mills L, Yang L, Zhang L, Sundsbak R, Shapiro V, Muders MH, Smyrk T, Couch FJ
Gastroenterology. 2011
PubMed ID: 21199651
-
Tissue-specific signatures of activating PIK3CA and RAS mutations in carcinosarcomas of gynecologic origin.
Growdon WB, Roussel BN, Scialabba VL, Foster R, Dias-Santagata D, Iafrate AJ, Ellisen LW, Tambouret RH, Rueda BR, Borger DR
Gynecol Oncol. 2011
PubMed ID: 21168197
-
Genetic aberrations in primary esophageal melanomas: molecular analysis of c-KIT, PDGFR, KRAS, NRAS and BRAF in a series of 10 cases.
Langer R, Becker K, Feith M, Friess H, Höfler H, Keller G
Mod Pathol. 2011
PubMed ID: 21131919
-
A MEK inhibitor abrogates myeloproliferative disease in Kras mutant mice.
Lyubynska N, Gorman MF, Lauchle JO, Hong WX, Akutagawa JK, Shannon K, Braun BS
Sci Transl Med. 2011
PubMed ID: 21451123
-
Activation of NF-kappaB is a novel target of KRAS-induced endometrial carcinogenesis.
Mizumoto Y, Kyo S, Kiyono T, Takakura M, Nakamura M, Maida Y, Mori N, Bono Y, Sakurai H, Inoue M
Clin Cancer Res. 2011
PubMed ID: 21411444
-
Activated KrasG¹²D is associated with invasion and metastasis of pancreatic cancer cells through inhibition of E-cadherin.
Rachagani S, Senapati S, Chakraborty S, Ponnusamy MP, Kumar S, Smith LM, Jain M, Batra SK
Br J Cancer. 2011
PubMed ID: 21364589
-
KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients.
Knijn N, Mekenkamp LJ, Klomp M, Vink-Börger ME, Tol J, Teerenstra S, Meijer JW, Tebar M, Riemersma S, van Krieken JH, Punt CJ, Nagtegaal ID
Br J Cancer. 2011
PubMed ID: 21364579
-
Protein kinase C δ is a downstream effector of oncogenic K-ras in lung tumors.
Symonds JM, Ohm AM, Carter CJ, Heasley LE, Boyle TA, Franklin WA, Reyland ME
Cancer Res. 2011
PubMed ID: 21335545
-
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism.
Sureban SM, May R, Lightfoot SA, Hoskins AB, Lerner M, Brackett DJ, Postier RG, Ramanujam R, Mohammed A, Rao CV, Wyche JH, Anant S, Houchen CW
Cancer Res. 2011
PubMed ID: 21285251
-
Oncogenic synergism between ErbB1, nucleolin, and mutant Ras.
Farin K, Schokoroy S, Haklai R, Cohen-Or I, Elad-Sfadia G, Reyes-Reyes ME, Bates PJ, Cox AD, Kloog Y, Pinkas-Kramarski R
Cancer Res. 2011
PubMed ID: 21257709
-
IMP-1 displays cross-talk with K-Ras and modulates colon cancer cell survival through the novel proapoptotic protein CYFIP2.
Mongroo PS, Noubissi FK, Cuatrecasas M, Kalabis J, King CE, Johnstone CN, Bowser MJ, Castells A, Spiegelman VS, Rustgi AK
Cancer Res. 2011
PubMed ID: 21252116
-
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis.
Niemela JE, Lu L, Fleisher TA, Davis J, Caminha I, Natter M, Beer LA, Dowdell KC, Pittaluga S, Raffeld M, Rao VK, Oliveira JB
Blood. 2011
PubMed ID: 21079152
-
Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation.
Takagi M, Shinoda K, Piao J, Mitsuiki N, Takagi M, Matsuda K, Muramatsu H, Doisaki S, Nagasawa M, Morio T, Kasahara Y, Koike K, Kojima S, Takao A, Mizutani S
Blood. 2011
PubMed ID: 21063026
-
Oncogenic Ras abrogates MEK SUMOylation that suppresses the ERK pathway and cell transformation.
Kubota Y, O'Grady P, Saito H, Takekawa M
Nat Cell Biol. 2011
PubMed ID: 21336309
-
Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.
Kaji E, Kato J, Suzuki H, Akita M, Horii J, Saito S, Higashi R, Ishikawa S, Kuriyama M, Hiraoka S, Uraoka T, Yamamoto K
J Gastroenterol Hepatol. 2011
PubMed ID: 21332555
-
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression.
Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM
Nat Genet. 2011
PubMed ID: 21317887
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E
Genes Dev. 2011
PubMed ID: 21317241
-
Mutations in the RAS/RAF/MAP kinase pathway commonly occur in gallbladder adenomas but are uncommon in gallbladder adenocarcinomas.
Pai RK, Mojtahed K, Pai RK
Appl Immunohistochem Mol Morphol. 2011
PubMed ID: 21307665
-
Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.
Parker LA, Porta M, Lumbreras B, López T, Guarner L, Hernández-Aguado I, Carrato A, Corominas JM, Rifà J, Fernandez E, Alguacil J, Malats N, Real FX
Eur J Epidemiol. 2011
PubMed ID: 21298467
-
Vascular smooth muscle cell proliferation is influenced by let-7d microRNA and its interaction with KRAS.
Yu ML, Wang JF, Wang GK, You XH, Zhao XX, Jing Q, Qin YW
Circ J. 2011
PubMed ID: 21266788
-
KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.
Tie J, Lipton L, Desai J, Gibbs P, Jorissen RN, Christie M, Drummond KJ, Thomson BN, Usatoff V, Evans PM, Pick AW, Knight S, Carne PW, Berry R, Polglase A, McMurrick P, Zhao Q, Busam D, Strausberg RL, Domingo E, Tomlinson IP, Midgley R, Kerr D, Sieber OM
Clin Cancer Res. 2011
PubMed ID: 21239505
-
KRAS(G12V) enhances proliferation and initiates myelomonocytic differentiation in human stem/progenitor cells via intrinsic and extrinsic pathways.
Fatrai S, van Gosliga D, Han L, Daenen SM, Vellenga E, Schuringa JJ
J Biol Chem. 2011
PubMed ID: 21169357
-
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.
Kiessling MK, Oberholzer PA, Mondal C, Karpova MB, Zipser MC, Lin WM, Girardi M, Macconaill LE, Kehoe SM, Hatton C, French LE, Garraway LA, Polier G, Süss D, Klemke CD, Krammer PH, Gülow K, Dummer R
Blood. 2011
PubMed ID: 21209378
-
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
Shen H, Yuan Y, Hu HG, Zhong X, Ye XX, Li MD, Fang WJ, Zheng S
World J Gastroenterol. 2011
PubMed ID: 21390154
-
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers.
Ting DT, Lipson D, Paul S, Brannigan BW, Akhavanfard S, Coffman EJ, Contino G, Deshpande V, Iafrate AJ, Letovsky S, Rivera MN, Bardeesy N, Maheswaran S, Haber DA
Science. 2011
PubMed ID: 21233348
-
Detection of precursor lesions of pancreatic adenocarcinoma in PET-CT in a genetically engineered mouse model of pancreatic cancer.
Fendrich V, Schneider R, Maitra A, Jacobsen ID, Opfermann T, Bartsch DK
Neoplasia. 2011
PubMed ID: 21403843
-
Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy.
Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H, Soh J, Sato M, Yanagitani N, Kaira K, Xie Y, Gazdar AF, Mori M, Minna JD
Mol Cancer Ther. 2011
PubMed ID: 21306997
-
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53.
Timpson P, McGhee EJ, Morton JP, von Kriegsheim A, Schwarz JP, Karim SA, Doyle B, Quinn JA, Carragher NO, Edward M, Olson MF, Frame MC, Brunton VG, Sansom OJ, Anderson KI
Cancer Res. 2011
PubMed ID: 21266354
-
Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas.
Ishii T, Notohara K, Umapathy A, Mallitt KA, Chikuba H, Moritani Y, Tanaka N, Rosty C, Matsubara N, Jass J, Leggett B, Whitehall V
Am J Surg Pathol. 2011
PubMed ID: 21263241
-
KRAS gene mutation in colorectal cancer is correlated with increased proliferation and spontaneous apoptosis.
Liu X, Jakubowski M, Hunt JL
Am J Clin Pathol. 2011
PubMed ID: 21228365
-
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Luo F, Poulogiannis G, Ye H, Hamoudi R, Zhang W, Dong G, Arends MJ
J Pathol. 2011
PubMed ID: 21171084
-
NKX2.2 suppresses self-renewal of glioma-initiating cells.
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
Cancer Res. 2011
PubMed ID: 21169405
-
Tumor KRAS status predicts responsiveness to panitumumab in Japanese patients with metastatic colorectal cancer.
Doi T, Tahara M, Yoshino T, Yamazaki K, Tamura T, Yamada Y, Yang BB, Oliner KS, Otani S, Asahi D
Jpn J Clin Oncol. 2011
PubMed ID: 21169348
-
Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling.
Mukhopadhyay A, Krishnaswami SR, Yu BD
J Invest Dermatol. 2011
PubMed ID: 20944652
-
Reflex testing of resected stage I through III lung adenocarcinomas for EGFR and KRAS mutation: report on initial experience and clinical utility at a single center.
D'Angelo SP, Park B, Azzoli CG, Kris MG, Rusch V, Ladanyi M, Zakowski MF
J Thorac Cardiovasc Surg. 2011
PubMed ID: 20933246
-
Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression.
DuPage M, Cheung AF, Mazumdar C, Winslow MM, Bronson R, Schmidt LM, Crowley D, Chen J, Jacks T
Cancer Cell. 2011
PubMed ID: 21251614
-
Co-expression of matrix metalloproteinase-7 (MMP-7) and phosphorylated insulin growth factor receptor I (pIGF-1R) correlates with poor prognosis in patients with wild-type KRAS treated with cetuximab or panitumumab: a GEMCAD study.
Hörndler C, Gallego R, García-Albeniz X, Alonso-Espinaco V, Alonso V, Escudero P, Jimeno M, Ortego J, Codony-Servat J, Fernández-Martos C, Calatrava A, Marín-Aguilera M, Muñoz J, Castellví-Bel S, Castells A, Rubini M, Gascón P, Maurel J
Cancer Biol Ther. 2011
PubMed ID: 21099348
-
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP
PLoS One. 2011
PubMed ID: 22022614
-
Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR.
Santis G, Angell R, Nickless G, Quinn A, Herbert A, Cane P, Spicer J, Breen R, McLean E, Tobal K
PLoS One. 2011
PubMed ID: 21949883
-
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, Pintzas A
Mol Cancer. 2011
PubMed ID: 21943101
-
Interferon-β signaling contributes to Ras transformation.
Tsai YC, Pestka S, Wang LH, Runnels LW, Wan S, Lyu YL, Liu LF
PLoS One. 2011
PubMed ID: 21897875
-
KRAS mutation in metastatic pancreatic ductal adenocarcinoma: results of a multicenter phase II study evaluating efficacy of cetuximab plus gemcitabine/oxaliplatin (GEMOXCET) in first-line therapy.
Kullmann F, Hartmann A, Stöhr R, Messmann H, Dollinger MM, Trojan J, Fuchs M, Hollerbach S, Harder J, Troppmann M, Kutscheidt A, Endlicher E
Oncology. 2011
PubMed ID: 21894049
-
Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer.
LaConti JJ, Shivapurkar N, Preet A, Deslattes Mays A, Peran I, Kim SE, Marshall JL, Riegel AT, Wellstein A
PLoS One. 2011
PubMed ID: 21738581
-
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
-
Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas.
Al-Ghamdi S, Albasri A, Cachat J, Ibrahem S, Muhammad BA, Jackson D, Nateri AS, Kindle KB, Ilyas M
PLoS One. 2011
PubMed ID: 21698197
-
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-κB signaling pathways.
Wang Z, Banerjee S, Ahmad A, Li Y, Azmi AS, Gunn JR, Kong D, Bao B, Ali S, Gao J, Mohammad RM, Miele L, Korc M, Sarkar FH
PLoS One. 2011
PubMed ID: 21673986
-
Plasma proteome profiles associated with inflammation, angiogenesis, and cancer.
Kelly-Spratt KS, Pitteri SJ, Gurley KE, Liggitt D, Chin A, Kennedy J, Wong CH, Zhang Q, Buson TB, Wang H, Hanash SM, Kemp CJ
PLoS One. 2011
PubMed ID: 21589862
-
Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice.
Kamisawa T, Takuma K, Tabata T, Egawa N, Yamaguchi T
Hepatogastroenterology. 2011
PubMed ID: 21510309
-
Intra-tumoral heterogeneity of KRAS and BRAF mutation status in patients with advanced colorectal cancer (aCRC) and cost-effectiveness of multiple sample testing.
Richman SD, Chambers P, Seymour MT, Daly C, Grant S, Hemmings G, Quirke P
Anal Cell Pathol (Amst). 2011
PubMed ID: 21483104
-
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.
Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ
Sci Signal. 2011
PubMed ID: 21447798
-
Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice.
Sun L, Zhang Q, Luan H, Zhan Z, Wang C, Sun B
J Exp Clin Cancer Res. 2011
PubMed ID: 21414214
-
In vivo fluorescence-based endoscopic detection of colon dysplasia in the mouse using a novel peptide probe.
Miller SJ, Joshi BP, Feng Y, Gaustad A, Fearon ER, Wang TD
PLoS One. 2011
PubMed ID: 21408169
-
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.
van Eijk R, Licht J, Schrumpf M, Talebian Yazdi M, Ruano D, Forte GI, Nederlof PM, Veselic M, Rabe KF, Annema JT, Smit V, Morreau H, van Wezel T
PLoS One. 2011
PubMed ID: 21408138
-
Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors.
Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC
Sci Signal. 2011
PubMed ID: 21386094
-
Effect of p21Ras in vitro intervention on the phenotype of airway smooth muscle cells from asthmatic rats.
Qiu C, Li N, Chen DD, Li FR
Chin Med J (Engl). 2011
PubMed ID: 21362304
-
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
Samuel MS, Lourenço FC, Olson MF
PLoS One. 2011
PubMed ID: 21358804
-
Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model.
Ray KC, Bell KM, Yan J, Gu G, Chung CH, Washington MK, Means AL
PLoS One. 2011
PubMed ID: 21311774
-
Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition.
Shankar S, Nall D, Tang SN, Meeker D, Passarini J, Sharma J, Srivastava RK
PLoS One. 2011
PubMed ID: 21304978
-
KRAS mutation analysis helps to differentiate between pulmonary metastasis from colon adenocarcinoma in situ and primary lung adenocarcinoma.
Ortiz TM, Cohen DW, Kent MS, Jänne PA, Costa DB
J Thorac Oncol. 2011
PubMed ID: 21178719
-
Hepatocellular carcinoma with persistent hepatitis B virus infection shows unusual downregulation of Ras expression and differential response to Ras mediated signaling.
Bose S, Sakhuja P, Bezawada L, Agarwal AK, Kazim SN, Khan LA, Sarin SK, Ramakrishna G
J Gastroenterol Hepatol. 2011
PubMed ID: 21175807
-
Evaluation of Kras gene mutation and copy number gain in non-small cell lung cancer.
Sasaki H, Hikosaka Y, Kawano O, Moriyama S, Yano M, Fujii Y
J Thorac Oncol. 2011
PubMed ID: 21150464
-
Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue.
Ekelund S, Papadogiannakis N, Olivecrona H, Lindforss U
Oncol Rep. 2011
PubMed ID: 21109984
-
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Onozato W, Yamashita K, Yamashita K, Kuba T, Katoh H, Nakamura T, Sato T, Ihara A, Okayasu I, Watanabe M
J Surg Oncol. 2011
PubMed ID: 21031422
-
Inactivating GGTase-I reduces disease phenotypes in a mouse model of K-RAS-induced myeloproliferative disease.
Sjogren AK, Andersson KM, Khan O, Olofsson FJ, Karlsson C, Bergo MO
Leukemia. 2011
PubMed ID: 20975663
-
Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.
Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR
Hum Mutat. 2011
PubMed ID: 20949621
-
Repression of the miR-143/145 cluster by oncogenic Ras initiates a tumor-promoting feed-forward pathway.
Kent OA, Chivukula RR, Mullendore M, Wentzel EA, Feldmann G, Lee KH, Liu S, Leach SD, Maitra A, Mendell JT
Genes Dev. 2010
PubMed ID: 21159816
-
Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3.
da Cunha Santos G, Dhani N, Tu D, Chin K, Ludkovski O, Kamel-Reid S, Squire J, Parulekar W, Moore MJ, Tsao MS
Cancer. 2010
PubMed ID: 20824720
-
Impact of KRAS mutation and PTEN expression on cetuximab-treated colorectal cancer.
Li FH, Shen L, Li ZH, Luo HY, Qiu MZ, Zhang HZ, Li YH, Xu RH
World J Gastroenterol. 2010
PubMed ID: 21155011
-
Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.
Kosakowska EA, Stec R, Charkiewicz R, Skoczek M, Chyczewski L
Folia Histochem Cytobiol. 2010
PubMed ID: 21478103
-
KRAS genotyping as biomarker in colorectal cancer: a comparison of three commercial kits on histologic material.
Cavallini A, Valentini AM, Lippolis C, Campanella D, Guerra V, Caruso ML
Anticancer Res. 2010
PubMed ID: 21187522
-
Prognostic and predictive implications of EGFR mutations, EGFR copy number and KRAS mutations in advanced stage lung adenocarcinoma.
Bonanno L, Schiavon M, Nardo G, Bertorelle R, Bonaldi L, Galligioni A, Indraccolo S, Pasello G, Rea F, Favaretto A
Anticancer Res. 2010
PubMed ID: 21187500
-
Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer.
Hoque MO, Brait M, Rosenbaum E, Poeta ML, Pal P, Begum S, Dasgupta S, Carvalho AL, Ahrendt SA, Westra WH, Sidransky D
J Thorac Oncol. 2010
PubMed ID: 21102258
-
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner.
Gilad O, Nabet BY, Ragland RL, Schoppy DW, Smith KD, Durham AC, Brown EJ
Cancer Res. 2010
PubMed ID: 21098704
-
Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.
de Launay D, Vreijling J, Hartkamp LM, Karpus ON, Abreu JR, van Maanen MA, Sanders ME, Grabiec AM, Hamann J, Ørum H, Vervoordeldonk MJ, Fluiter K, Tak PP, Reedquist KA
Am J Pathol. 2010
PubMed ID: 20971740
-
Increased sensitivity of KRAS mutation detection by high-resolution melting analysis of COLD-PCR products.
Kristensen LS, Daugaard IL, Christensen M, Hamilton-Dutoit S, Hager H, Hansen LL
Hum Mutat. 2010
PubMed ID: 20848649
-
MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.
Zhang X, Yang H, Lee JJ, Kim E, Lippman SM, Khuri FR, Spitz MR, Lotan R, Hong WK, Wu X
Carcinogenesis. 2010
PubMed ID: 20819778
-
KRAS mutation testing of colorectal cancer for anti-EGFR therapy: dogmas versus evidence.
Tímár J, Hegedüs B, Rásó E
Curr Cancer Drug Targets. 2010
PubMed ID: 20718705
-
Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.
Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK
Biochimie. 2010
PubMed ID: 20713122
-
KRAS mutation analysis on cytological specimens of metastatic colo-rectal cancer.
Troncone G, Malapelle U, Cozzolino I, Palombini L
Diagn Cytopathol. 2010
PubMed ID: 20049979
-
Stage-specific sensitivity to p53 restoration during lung cancer progression.
Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, Sanchez-Rivera FJ, Resnick R, Bronson R, Hemann MT, Jacks T
Nature. 2010
PubMed ID: 21107428
-
Selective activation of p53-mediated tumour suppression in high-grade tumours.
Junttila MR, Karnezis AN, Garcia D, Madriles F, Kortlever RM, Rostker F, Brown Swigart L, Pham DM, Seo Y, Evan GI, Martins CP
Nature. 2010
PubMed ID: 21107427
-
Cooperative interactions of PTEN deficiency and RAS activation in melanoma metastasis.
Nogueira C, Kim KH, Sung H, Paraiso KH, Dannenberg JH, Bosenberg M, Chin L, Kim M
Oncogene. 2010
PubMed ID: 20711233
-
Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.
Bhagatji P, Leventis R, Rich R, Lin CJ, Silvius JR
Biophys J. 2010
PubMed ID: 21081081
-
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Chen HC, Chen HJ, Khan MA, Rao ZZ, Wan XX, Tan B, Zhang DZ
Tumour Biol. 2010
PubMed ID: 21080251
-
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.
Lee KE, Bar-Sagi D
Cancer Cell. 2010
PubMed ID: 21075310
-
Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer.
Skoulidis F, Cassidy LD, Pisupati V, Jonasson JG, Bjarnason H, Eyfjord JE, Karreth FA, Lim M, Barber LM, Clatworthy SA, Davies SE, Olive KP, Tuveson DA, Venkitaraman AR
Cancer Cell. 2010
PubMed ID: 21056012
-
Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients.
Winder T, Zhang W, Yang D, Ning Y, Bohanes P, Gerger A, Wilson PM, Pohl A, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ
Clin Cancer Res. 2010
PubMed ID: 20935157
-
The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients.
Camps C, Jantus-Lewintre E, Cabrera A, Blasco A, Sanmartín E, Gallach S, Caballero C, Del Pozo N, Rosell R, Guijarro R, Sirera R
Lung Cancer. 2010
PubMed ID: 21074889
-
KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis.
Deschoolmeester V, Boeckx C, Baay M, Weyler J, Wuyts W, Van Marck E, Peeters M, Lardon F, Vermorken JB
Br J Cancer. 2010
PubMed ID: 20959826
-
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
-
KRAS and PIK3CA but not BRAF genes are frequently mutated in Chinese cholangiocarcinoma patients.
Xu RF, Sun JP, Zhang SR, Zhu GS, Li LB, Liao YL, Xie JM, Liao WJ
Biomed Pharmacother. 2010
PubMed ID: 21051183
-
LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling.
Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, Fang Z, Wu J, Han X, Zhang J, Sun Y, Wu G, Padera R, Chen H, Wong KK, Ge G, Ji H
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20956321
-
Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?
Rizzo S, Bronte G, Fanale D, Corsini L, Silvestris N, Santini D, Gulotta G, Bazan V, Gebbia N, Fulfaro F, Russo A
Cancer Treat Rev. 2010
PubMed ID: 21129611
-
Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma.
Bronte G, Rizzo S, La Paglia L, Adamo V, Siragusa S, Ficorella C, Santini D, Bazan V, Colucci G, Gebbia N, Russo A
Cancer Treat Rev. 2010
PubMed ID: 21129606
-
Therapeutic implications of resistance to molecular therapies in metastatic colorectal cancer.
Sartore-Bianchi A, Bencardino K, Cassingena A, Venturini F, Funaioli C, Cipani T, Amatu A, Pietrogiovanna L, Schiavo R, Di Nicolantonio F, Artale S, Bardelli A, Siena S
Cancer Treat Rev. 2010
PubMed ID: 21129603
-
The epidermal growth factor receptor inhibitor gefitinib prevents the progression of pancreatic lesions to carcinoma in a conditional LSL-KrasG12D/+ transgenic mouse model.
Mohammed A, Janakiram NB, Li Q, Madka V, Ely M, Lightfoot S, Crawford H, Steele VE, Rao CV
Cancer Prev Res (Phila). 2010
PubMed ID: 21084261
-
Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.
Vicent S, Chen R, Sayles LC, Lin C, Walker RG, Gillespie AK, Subramanian A, Hinkle G, Yang X, Saif S, Root DE, Huff V, Hahn WC, Sweet-Cordero EA
J Clin Invest. 2010
PubMed ID: 20972333
-
K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia.
Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC
Cancer Res. 2010
PubMed ID: 20959488
-
Identification of susceptibility loci in a mouse model of KRASG12D-driven pancreatic cancer.
Jorgenson TC, Williams BR, Wendland A, Bilger A, Sandgren EP, Drinkwater NR
Cancer Res. 2010
PubMed ID: 20959479
-
Somatic mutations of signaling genes in non-small-cell lung cancer.
Sanders HR, Albitar M
Cancer Genet Cytogenet. 2010
PubMed ID: 20951313
-
Somatic mutations in epidermal growth factor receptor signaling pathway genes in non-small cell lung cancers.
Lee SY, Kim MJ, Jin G, Yoo SS, Park JY, Choi JE, Jeon HS, Cho S, Lee EB, Cha SI, Park TI, Kim CH, Jung TH, Park JY
J Thorac Oncol. 2010
PubMed ID: 20881644
-
ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia.
Gelsi-Boyer V, Trouplin V, Roquain J, Adélaïde J, Carbuccia N, Esterni B, Finetti P, Murati A, Arnoulet C, Zerazhi H, Fezoui H, Tadrist Z, Nezri M, Chaffanet M, Mozziconacci MJ, Vey N, Birnbaum D
Br J Haematol. 2010
PubMed ID: 20880116
-
Mutational analyses of the BRAF, KRAS, and PIK3CA genes in oral squamous cell carcinoma.
Bruckman KC, Schönleben F, Qiu W, Woo VL, Su GH
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010
PubMed ID: 20813562
-
A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
-
Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas.
Gaedcke J, Grade M, Jung K, Camps J, Jo P, Emons G, Gehoff A, Sax U, Schirmer M, Becker H, Beissbarth T, Ried T, Ghadimi BM
Genes Chromosomes Cancer. 2010
PubMed ID: 20725992
-
Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy.
Moses W, Weng J, Sansano I, Peng M, Khanafshar E, Ljung BM, Duh QY, Clark OH, Kebebew E
World J Surg. 2010
PubMed ID: 20703476
-
The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer.
El-Serafi MM, Bahnassy AA, Ali NM, Eid SM, Kamel MM, Abdel-Hamid NA, Zekri AR
Cancer. 2010
PubMed ID: 20652953
-
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
Zhao S, Wang Y, Cao L, Ouellette MM, Freeman JW
Int J Cancer. 2010
PubMed ID: 20473902
-
Somatic p16(INK4a) loss accelerates melanomagenesis.
Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE
Oncogene. 2010
PubMed ID: 20697345
-
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.
De Roock W, Jonker DJ, Di Nicolantonio F, Sartore-Bianchi A, Tu D, Siena S, Lamba S, Arena S, Frattini M, Piessevaux H, Van Cutsem E, O'Callaghan CJ, Khambata-Ford S, Zalcberg JR, Simes J, Karapetis CS, Bardelli A, Tejpar S
JAMA. 2010
PubMed ID: 20978259
-
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.
Chang MH, Lee IK, Si Y, Lee KS, Woo IS, Byun JH
Cancer Chemother Pharmacol. 2010
PubMed ID: 20972872
-
Phase II study of dasatinib in patients with advanced non-small-cell lung cancer.
Johnson FM, Bekele BN, Feng L, Wistuba I, Tang XM, Tran HT, Erasmus JJ, Hwang LL, Takebe N, Blumenschein GR, Lippman SM, Stewart DJ
J Clin Oncol. 2010
PubMed ID: 20855820
-
Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.
Lee da Y, Yeh TH, Emnett RJ, White CR, Gutmann DH
Genes Dev. 2010
PubMed ID: 20876733
-
Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia.
Wiemels JL, Kang M, Chang JS, Zheng L, Kouyoumji C, Zhang L, Smith MT, Scelo G, Metayer C, Buffler P, Wiencke JK
Blood Cells Mol Dis. 2010
PubMed ID: 20688547
-
Genetic variation in C-reactive protein in relation to colon and rectal cancer risk and survival.
Slattery ML, Curtin K, Poole EM, Duggan DJ, Samowitz WS, Peters U, Caan BJ, Potter JD, Ulrich CM
Int J Cancer. 2010
PubMed ID: 20949557
-
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.
Zlobec I, Molinari F, Martin V, Mazzucchelli L, Saletti P, Trezzi R, De Dosso S, Vlajnic T, Frattini M, Lugli A
World J Gastroenterol. 2010
PubMed ID: 20939111
-
KRAS and BRAF Mutations and PTEN Expression Do Not Predict Efficacy of Cetuximab-Based Chemoradiotherapy in Locally Advanced Rectal Cancer.
Erben P, Ströbel P, Horisberger K, Popa J, Bohn B, Hanfstein B, Kähler G, Kienle P, Post S, Wenz F, Hochhaus A, Hofheinz RD
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20947270
-
Oncogenic mutations in gastric cancer with microsatellite instability.
Corso G, Velho S, Paredes J, Pedrazzani C, Martins D, Milanezi F, Pascale V, Vindigni C, Pinheiro H, Leite M, Marrelli D, Sousa S, Carneiro F, Oliveira C, Roviello F, Seruca R
Eur J Cancer. 2010
PubMed ID: 20937558
-
Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer.
Bennani B, Gilles S, Fina F, Nanni I, Ibrahimi SA, Riffi AA, Nejjari C, Benajeh DA, El Abkari M, Martin PM, Ouafik L
Int J Biol Markers. 2010
PubMed ID: 21161938
-
Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis.
Mariani P, Lae M, Degeorges A, Cacheux W, Lappartient E, Margogne A, Pierga JY, Girre V, Mignot L, Falcou MC, Salmon RJ, Delattre O, De Cremoux P
Anticancer Res. 2010
PubMed ID: 21036746
-
Inhibition of Myc effectively targets KRAS mutation-positive lung cancer expressing high levels of Myc.
Fukazawa T, Maeda Y, Matsuoka J, Yamatsuji T, Shigemitsu K, Morita I, Faiola F, Durbin ML, Soucek L, Naomoto Y
Anticancer Res. 2010
PubMed ID: 21036740
-
Endocervical-like (Müllerian) mucinous borderline tumours of the ovary are frequently associated with the KRAS mutation.
Kim KR, Choi J, Hwang JE, Baik YA, Shim JY, Kim YM, Robboy SJ
Histopathology. 2010
PubMed ID: 20955384
-
Evaluation of Kras gene mutation and copy number in thymic carcinomas and thymomas.
Sasaki H, Yano M, Fujii Y
J Thorac Oncol. 2010
PubMed ID: 20871271
-
A brief retrospective report on the feasibility of epidermal growth factor receptor and KRAS mutation analysis in transesophageal ultrasound- and endobronchial ultrasound-guided fine needle cytological aspirates.
Schuurbiers OC, Looijen-Salamon MG, Ligtenberg MJ, van der Heijden HF
J Thorac Oncol. 2010
PubMed ID: 20871266
-
Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.
Rivera M, Ricarte-Filho J, Tuttle RM, Ganly I, Shaha A, Knauf J, Fagin J, Ghossein R
Thyroid. 2010
PubMed ID: 20860430
-
Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.
Davies CC, Chakraborty A, Cipriani F, Haigh K, Haigh JJ, Behrens A
Nat Cell Biol. 2010
PubMed ID: 20852630
-
KRAS gene mutations in lung cancer: particulars established and issues unresolved.
Okudela K, Woo T, Kitamura H
Pathol Int. 2010
PubMed ID: 20846262
-
BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas.
Wong KK, Tsang YT, Deavers MT, Mok SC, Zu Z, Sun C, Malpica A, Wolf JK, Lu KH, Gershenson DM
Am J Pathol. 2010
PubMed ID: 20802181
-
The miR-217 microRNA functions as a potential tumor suppressor in pancreatic ductal adenocarcinoma by targeting KRAS.
Zhao WG, Yu SN, Lu ZH, Ma YH, Gu YM, Chen J
Carcinogenesis. 2010
PubMed ID: 20675343
-
p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma.
Doyle B, Morton JP, Delaney DW, Ridgway RA, Wilkins JA, Sansom OJ
J Pathol. 2010
PubMed ID: 20662002
-
Predictive and prognostic value of KRAS mutations in metastatic colorectal cancer patients treated with cetuximab: a meta-analysis of 22 studies.
Qiu LX, Mao C, Zhang J, Zhu XD, Liao RY, Xue K, Li J, Chen Q
Eur J Cancer. 2010
PubMed ID: 20580219
-
Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations.
Hiramatsu M, Ninomiya H, Inamura K, Nomura K, Takeuchi K, Satoh Y, Okumura S, Nakagawa K, Yamori T, Matsuura M, Morikawa T, Ishikawa Y
Lung Cancer. 2010
PubMed ID: 20117855
-
EGFR FISH Pattern of Chromosome 7 Disomy Predicts Resistance to Cetuximab in KRAS Wild-type Metastatic Colorectal Cancer Patients.
Li YH, Wang F, Shen L, Deng YM, Shao Q, Feng F, An X, Wang FH, Wang ZQ, Xu RH, Shao JY
Clin Cancer Res. 2010
PubMed ID: 20884623
-
Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Bengala C, Bettelli S, Bertolini F, Sartori G, Fontana A, Malavasi N, Depenni R, Zironi S, Del Giovane C, Luppi G, Conte PF
Br J Cancer. 2010
PubMed ID: 20842128
-
[Comparison of EGFR and KRAS status between primary non-small cell lung cancer and corresponding metastases: a systematic review and meta-analysis].
Han C, Zou H, Ma J, Zhou Y, Zhao J
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20840818
-
PTEN loss accelerates KrasG12D-induced pancreatic cancer development.
Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H
Cancer Res. 2010
PubMed ID: 20807812
-
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.
Hatley ME, Patrick DM, Garcia MR, Richardson JA, Bassel-Duby R, van Rooij E, Olson EN
Cancer Cell. 2010
PubMed ID: 20832755
-
The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.
Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI
Oncogene. 2010
PubMed ID: 20581865
-
NRAS mutations are rare in colorectal cancer.
Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S
Diagn Mol Pathol. 2010
PubMed ID: 20736745
-
PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling.
Halilovic E, She QB, Ye Q, Pagliarini R, Sellers WR, Solit DB, Rosen N
Cancer Res. 2010
PubMed ID: 20699365
-
Chemoradiotherapy and gefitinib in stage III non-small cell lung cancer with epidermal growth factor receptor and KRAS mutation analysis: cancer and leukemia group B (CALEB) 30106, a CALGB-stratified phase II trial.
Ready N, Jänne PA, Bogart J, Dipetrillo T, Garst J, Graziano S, Gu L, Wang X, Green MR, Vokes EE, Cancer, Leukemia Group B, Chicago, IL
J Thorac Oncol. 2010
PubMed ID: 20686428
-
Gene methylation of SFRP2, P16, DAPK1, HIC1, and MGMT and KRAS mutations in sporadic colorectal cancer.
Pehlivan S, Artac M, Sever T, Bozcuk H, Kilincarslan C, Pehlivan M
Cancer Genet Cytogenet. 2010
PubMed ID: 20682398
-
Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers.
Liao W, Liao Y, Zhou JX, Xie J, Chen J, Huang W, Luo R
Anat Rec (Hoboken). 2010
PubMed ID: 20652941
-
Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.
Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL
Am J Pathol. 2010
PubMed ID: 20639455
-
Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415).
Gold PJ, Goldman B, Iqbal S, Leichman LP, Zhang W, Lenz HJ, Blanke CD
J Thorac Oncol. 2010
PubMed ID: 20631636
-
Involvement of RAGE, NADPH oxidase, and Ras/Raf-1 pathway in glycated LDL-induced expression of heat shock factor-1 and plasminogen activator inhibitor-1 in vascular endothelial cells.
Sangle GV, Zhao R, Mizuno TM, Shen GX
Endocrinology. 2010
PubMed ID: 20630999
-
The use of COLD-PCR and high-resolution melting analysis improves the limit of detection of KRAS and BRAF mutations in colorectal cancer.
Mancini I, Santucci C, Sestini R, Simi L, Pratesi N, Cianchi F, Valanzano R, Pinzani P, Orlando C
J Mol Diagn. 2010
PubMed ID: 20616366
-
Immunoglobulin G fragment C receptor polymorphisms and KRAS mutations: are they useful biomarkers of clinical outcome in advanced colorectal cancer treated with anti-EGFR-based therapy?
Paez D, Paré L, Espinosa I, Salazar J, del Rio E, Barnadas A, Marcuello E, Baiget M
Cancer Sci. 2010
PubMed ID: 20550522
-
A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk.
Ratner E, Lu L, Boeke M, Barnett R, Nallur S, Chin LJ, Pelletier C, Blitzblau R, Tassi R, Paranjape T, Hui P, Godwin AK, Yu H, Risch H, Rutherford T, Schwartz P, Santin A, Matloff E, Zelterman D, Slack FJ, Weidhaas JB
Cancer Res. 2010
PubMed ID: 20647319
-
First-line erlotinib and bevacizumab in patients with locally advanced and/or metastatic non-small-cell lung cancer: a phase II study including molecular imaging.
Dingemans AM, de Langen AJ, van den Boogaart V, Marcus JT, Backes WH, Scholtens HT, van Tinteren H, Hoekstra OS, Pruim J, Brans B, Thunnissen FB, Smit EF, Groen HJ
Ann Oncol. 2010
PubMed ID: 20702788
-
HIF-2alpha deletion promotes Kras-driven lung tumor development.
Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC, Keith B
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660313
-
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Bennecke M, Kriegl L, Bajbouj M, Retzlaff K, Robine S, Jung A, Arkan MC, Kirchner T, Greten FR
Cancer Cell. 2010
PubMed ID: 20708155
-
Feasibility and Robustness of Amplification Refractory Mutation System (ARMS)-based KRAS Testing Using Clinically Available Formalin-fixed, Paraffin-embedded Samples of Colorectal Cancers.
Ogasawara N, Bando H, Kawamoto Y, Yoshino T, Tsuchihara K, Ohtsu A, Esumi H
Jpn J Clin Oncol. 2010
PubMed ID: 20696815
-
[K-ras gene mutation in colorectal cancer and its clinicopathologic significance.]
Yuan Y, Hu HG, Ye XX, Shen H, Zheng S
Zhonghua Wai Ke Za Zhi. 2010
PubMed ID: 21055216
-
Detection of KRAS mutations in colorectal carcinoma patients with an integrated PCR/sequencing and real-time PCR approach.
Carotenuto P, Roma C, Rachiglio AM, Tatangelo F, Pinto C, Ciardiello F, Nappi O, Iaffaioli RV, Botti G, Normanno N
Pharmacogenomics. 2010
PubMed ID: 20712532
-
Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
Levy R, Grafi-Cohen M, Kraiem Z, Kloog Y
Mol Cancer Ther. 2010
PubMed ID: 20682656
-
Frequency of EGFR and KRAS mutations in Japanese patients with lung adenocarcinoma with features of the mucinous subtype of bronchioloalveolar carcinoma.
Hata A, Katakami N, Fujita S, Kaji R, Imai Y, Takahashi Y, Nishimura T, Tomii K, Ishihara K
J Thorac Oncol. 2010
PubMed ID: 20661086
-
Transplanting normal vascular proangiogenic cells to tumor-bearing mice triggers vascular remodeling and reduces hypoxia in tumors.
Sasajima J, Mizukami Y, Sugiyama Y, Nakamura K, Kawamoto T, Koizumi K, Fujii R, Motomura W, Sato K, Suzuki Y, Tanno S, Fujiya M, Sasaki K, Shimizu N, Karasaki H, Kono T, Kawabe J, Ii M, Yoshiara H, Kamiyama N, Ashida T, Bardeesy N, Chung DC, Kohgo Y
Cancer Res. 2010
PubMed ID: 20631070
-
Alcohol consumption and rectal tumor mutations and epigenetic changes.
Slattery ML, Wolff RK, Herrick JS, Curtin K, Caan BJ, Samowitz W
Dis Colon Rectum. 2010
PubMed ID: 20628283
-
Cycleave polymerase chain reaction method is practically applicable for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)/V-raf murine sarcoma viral oncogene homolog B1 (BRAF) genotyping in colorectal cancer.
Yokota T, Shibata N, Ura T, Takahari D, Shitara K, Muro K, Yatabe Y
Transl Res. 2010
PubMed ID: 20627194
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, Penault-Llorca F, Rougier P, Vincenzi B, Santini D, Tonini G, Cappuzzo F, Frattini M, Molinari F, Saletti P, De Dosso S, Martini M, Bardelli A, Siena S, Sartore-Bianchi A, Tabernero J, Macarulla T, Di Fiore F, Gangloff AO, Ciardiello F, Pfeiffer P, Qvortrup C, Hansen TP, Van Cutsem E, Piessevaux H, Lambrechts D, Delorenzi M, Tejpar S
Lancet Oncol. 2010
PubMed ID: 20619739
-
Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase.
Lee J, Choi KJ, Lim MJ, Hong F, Choi TG, Tak E, Lee S, Kim YJ, Chang SG, Cho JM, Ha J, Kim SS
Cell Res. 2010
PubMed ID: 20603646
-
Prognostic implications of epidermal growth factor receptor and KRAS gene mutations and epidermal growth factor receptor gene copy numbers in patients with surgically resectable non-small cell lung cancer in Taiwan.
Liu HP, Isaac Wu HD, Chang JW, Wu YC, Yang HY, Chen YT, Hsieh WY, Chen YT, Chen YR, Huang SF
J Thorac Oncol. 2010
PubMed ID: 20559151
-
Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas.
Gao B, Sun Y, Zhang J, Ren Y, Fang R, Han X, Shen L, Liu XY, Pao W, Chen H, Ji H
J Thorac Oncol. 2010
PubMed ID: 20559149
-
Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas.
Kuboki Y, Shiratori K, Hatori T, Fujita I, Kimijima A, Yamamoto M, Kobayashi M, Furukawa T
Mod Pathol. 2010
PubMed ID: 20495538
-
A novel mutant-enriched liquidchip technology for the qualitative detection of somatic mutations in KRAS gene from both serum and tissue samples.
Wu S, Zhu Z, He J, Luo X, Xu J, Ren-Heidenreich L
Clin Chem Lab Med. 2010
PubMed ID: 20482381
-
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest.
Morton JP, Jamieson NB, Karim SA, Athineos D, Ridgway RA, Nixon C, McKay CJ, Carter R, Brunton VG, Frame MC, Ashworth A, Oien KA, Evans TR, Sansom OJ
Gastroenterology. 2010
PubMed ID: 20452353
-
Diet, physical activity, and body size associations with rectal tumor mutations and epigenetic changes.
Slattery ML, Curtin K, Wolff RK, Herrick JS, Caan BJ, Samowitz W
Cancer Causes Control. 2010
PubMed ID: 20383576
-
EGFR fluorescence in situ hybridization-positive lung adenocarcinoma: incidence of coexisting KRAS and BRAF mutations.
Chiosea S, Shuai Y, Cieply K, Nikiforova MN, Dacic S
Hum Pathol. 2010
PubMed ID: 20381121
-
High sensitivity of both sequencing and real-time PCR analysis of KRAS mutations in colorectal cancer tissue.
Tol J, Dijkstra JR, Vink-Börger ME, Nagtegaal ID, Punt CJ, Van Krieken JH, Ligtenberg MJ
J Cell Mol Med. 2010
PubMed ID: 19453520
-
Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families.
Hollestelle A, Pelletier C, Hooning M, Crepin E, Schutte M, Look M, Collee JM, Nieuwlaat A, Dorssers LC, Seynaeve C, Aulchenko YS, Martens JW, van den Ouweland AM, Weidhaas JB
Breast Cancer Res Treat. 2010
PubMed ID: 20676756
-
Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells.
Cassano S, Agnese S, D'Amato V, Papale M, Garbi C, Castagnola P, Ruocco MR, Castellano I, De Vendittis E, Santillo M, Amente S, Porcellini A, Avvedimento EV
J Biol Chem. 2010
PubMed ID: 20495008
-
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma.
Mazur PK, Einwächter H, Lee M, Sipos B, Nakhai H, Rad R, Zimber-Strobl U, Strobl LJ, Radtke F, Klöppel G, Schmid RM, Siveke JT
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20624967
-
Distribution of some activating KRAS and BRAF mutations in Slovene patients with colorectal cancer.
Ličar A, Cerkovnik P, Novaković S
Med Oncol. 2010
PubMed ID: 20645028
-
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.
Zhang N, Bai H, David KK, Dong J, Zheng Y, Cai J, Giovannini M, Liu P, Anders RA, Pan D
Dev Cell. 2010
PubMed ID: 20643348
-
Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study.
Lubner SJ, Mahoney MR, Kolesar JL, Loconte NK, Kim GP, Pitot HC, Philip PA, Picus J, Yong WP, Horvath L, Van Hazel G, Erlichman CE, Holen KD
J Clin Oncol. 2010
PubMed ID: 20530271
-
The KRAS promoter responds to Myc-associated zinc finger and poly(ADP-ribose) polymerase 1 proteins, which recognize a critical quadruplex-forming GA-element.
Cogoi S, Paramasivam M, Membrino A, Yokoyama KK, Xodo LE
J Biol Chem. 2010
PubMed ID: 20457603
-
miRNA-96 suppresses KRAS and functions as a tumor suppressor gene in pancreatic cancer.
Yu S, Lu Z, Liu C, Meng Y, Ma Y, Zhao W, Liu J, Yu J, Chen J
Cancer Res. 2010
PubMed ID: 20610624
-
Genomic and biological characterization of exon 4 KRAS mutations in human cancer.
Janakiraman M, Vakiani E, Zeng Z, Pratilas CA, Taylor BS, Chitale D, Halilovic E, Wilson M, Huberman K, Ricarte Filho JC, Persaud Y, Levine DA, Fagin JA, Jhanwar SC, Mariadason JM, Lash A, Ladanyi M, Saltz LB, Heguy A, Paty PB, Solit DB
Cancer Res. 2010
PubMed ID: 20570890
-
The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice.
Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M
Oncogene. 2010
PubMed ID: 20473331
-
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M
Cancer Cell. 2010
PubMed ID: 20609353
-
A let-7 microRNA-binding site polymorphism in 3'-untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with cetuximab monotherapy.
Zhang W, Winder T, Ning Y, Pohl A, Yang D, Kahn M, Lurje G, Labonte MJ, Wilson PM, Gordon MA, Hu-Lieskovan S, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ
Ann Oncol. 2010
PubMed ID: 20603437
-
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.
Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsch DG, Wong KK, Kim CF
Cell Stem Cell. 2010
PubMed ID: 20621056
-
Noonan syndrome and systemic lupus erythematosus in a patient with a novel KRAS mutation.
Leventopoulos G, Denayer E, Makrythanasis P, Papapolychroniou C, Fryssira H
Clin Exp Rheumatol. 2010
PubMed ID: 20810036
-
Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.
Rogosnitzky M, Danks R
Anticancer Res. 2010
PubMed ID: 20683036
-
Use of cetuximab after failure of gefitinib in patients with advanced non-small-cell lung cancer.
Wu JY, Yang CH, Hsu YC, Yu CJ, Chang SH, Shih JY, Yang PC
Clin Lung Cancer. 2010
PubMed ID: 20630828
-
p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.
Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW
Genes Dev. 2010
PubMed ID: 20595231
-
KRAS mutation and microsatellite instability in endometrial adenocarcinomas showing MELF-type myometrial invasion.
Stewart CJ, Amanuel B, Grieu F, Carrello A, Iacopetta B
J Clin Pathol. 2010
PubMed ID: 20591910
-
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
Chen H, Tu H, Meng ZQ, Chen Z, Wang P, Liu LM
Eur J Surg Oncol. 2010
PubMed ID: 20542658
-
A mouse model of melanoma driven by oncogenic KRAS.
Milagre C, Dhomen N, Geyer FC, Hayward R, Lambros M, Reis-Filho JS, Marais R
Cancer Res. 2010
PubMed ID: 20516123
-
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Lee S, Choi H, Kim E, Kim H, Park YH, Yu DY, Yoon SJ, Kim J, Sheen Y, Park SN, Yoon DY
Int J Oncol. 2010
PubMed ID: 20514414
-
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
-
Correlation of FCGR3A and EGFR germline polymorphisms with the efficacy of cetuximab in KRAS wild-type metastatic colorectal cancer.
Pander J, Gelderblom H, Antonini NF, Tol J, van Krieken JH, van der Straaten T, Punt CJ, Guchelaar HJ
Eur J Cancer. 2010
PubMed ID: 20418097
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab.
Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Börger ME, van Cleef PH, van Krieken JH, Punt CJ, Nagtegaal ID
Eur J Cancer. 2010
PubMed ID: 20413299
-
TP53, EGFR, and KRAS mutations in relation to VHL inactivation and lifestyle risk factors in renal-cell carcinoma from central and eastern Europe.
Szymańska K, Moore LE, Rothman N, Chow WH, Waldman F, Jaeger E, Waterboer T, Foretova L, Navratilova M, Janout V, Kollarova H, Zaridze D, Matveev V, Mates D, Szeszenia-Dabrowska N, Holcatova I, Bencko V, Le Calvez-Kelm F, Villar S, Pawlita M, Boffetta P, Hainaut P, Brennan P
Cancer Lett. 2010
PubMed ID: 20137853
-
PIK3CA mutations in KRAS and BRAF wild type colorectal cancer patients. A study of Spanish population.
Herreros-Villanueva M, Gomez-Manero N, Muñiz P, García-Girón C, Coma Del Corral MJ
Mol Biol Rep. 2010
PubMed ID: 20571907
-
Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake.
Repunte-Canonigo V, van der Stap LD, Chen J, Sabino V, Wagner U, Zorrilla EP, Schumann G, Roberts AJ, Sanna PP
Brain Res. 2010
PubMed ID: 20388501
-
KRAS, BRAF, EGFR and HER2 gene status in a Spanish population of colorectal cancer.
Herreros-Villanueva M, Rodrigo M, Claver M, Muñiz P, Lastra E, García-Girón C, Coma Del Corral MJ
Mol Biol Rep. 2010
PubMed ID: 20563851
-
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors.
Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK
Cancer Cell. 2010
PubMed ID: 20541700
-
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA
Mod Pathol. 2010
PubMed ID: 20526288
-
Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.
Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K
Blood. 2010
PubMed ID: 20233966
-
Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis.
Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE, Ryeom S
Blood. 2010
PubMed ID: 20086246
-
[K-RAS gene mutations in patients with non-small cell lung cancer].
Zhang Y, Pan Z, Zhang X, Xu F, Zhang L
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20681447
-
PTPN11 and KRAS gene analysis in patients with Noonan and Noonan-like syndromes.
Brasil AS, Pereira AC, Wanderley LT, Kim CA, Malaquias AC, Jorge AA, Krieger JE, Bertola DR
Genet Test Mol Biomarkers. 2010
PubMed ID: 20578946
-
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS.
Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, Toftgård R
Nat Struct Mol Biol. 2010
PubMed ID: 20512148
-
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Hanlon L, Avila JL, Demarest RM, Troutman S, Allen M, Ratti F, Rustgi AK, Stanger BZ, Radtke F, Adsay V, Long F, Capobianco AJ, Kissil JL
Cancer Res. 2010
PubMed ID: 20484026
-
Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras.
Young NP, Jacks T
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20479239
-
A multicenter phase II study of erlotinib and sorafenib in chemotherapy-naive patients with advanced non-small cell lung cancer.
Lind JS, Dingemans AM, Groen HJ, Thunnissen FB, Bekers O, Heideman DA, Honeywell RJ, Giovannetti E, Peters GJ, Postmus PE, van Suylen RJ, Smit EF
Clin Cancer Res. 2010
PubMed ID: 20395213
-
Cetuximab-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of K-ras mutations.
Ibrahim EM, Zekri JM, Bin Sadiq BM
Int J Colorectal Dis. 2010
PubMed ID: 20309588
-
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.
Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF, Raats DA, Sprick MR, Schaefer U, Van Houdt WJ, De Bruijn MT, Schackmann RC, Derksen PW, Medema JP, Walczak H, Borel Rinkes IH, Kranenburg O
Gastroenterology. 2010
PubMed ID: 20188103
-
Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.
Sadow PM, Heinrich MC, Corless CL, Fletcher JA, Nosé V
Endocr Pathol. 2010
PubMed ID: 20012784
-
CD95 promotes tumour growth.
Chen L, Park SM, Tumanov AV, Hau A, Sawada K, Feig C, Turner JR, Fu YX, Romero IL, Lengyel E, Peter ME
Nature. 2010
PubMed ID: 20505730
-
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients.
Fariña-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, Rutten HJ, van den Brule AJ
Ann Oncol. 2010
PubMed ID: 20501503
-
Multiple genetic alterations in papillary thyroid cancer are associated with younger age at presentation.
Moses W, Weng J, Khanafshar E, Duh QY, Clark OH, Kebebew E
J Surg Res. 2010
PubMed ID: 19765726
-
[Significance of K-ras detection in colorectal cancer].
Xu XM, Zhang GL, Li MW, Wang DY, Lin JJ
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20646601
-
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity.
Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20421486
-
Multiplicity of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitors.
Benesova L, Minarik M, Jancarikova D, Belsanova B, Pesek M
Anticancer Res. 2010
PubMed ID: 20592359
-
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
Amosenko FA, Korchagina EL, Matveeva TI, Vaganov IuE, Vlasov SB, Poltavets NV, Veselov VV, Gar'kavtseva RF, Poliakov AV
Genetika. 2010
PubMed ID: 20583607
-
Calcium, vitamin D, VDR genotypes, and epigenetic and genetic changes in rectal tumors.
Slattery ML, Wolff RK, Herrick JS, Caan BJ, Samowitz W
Nutr Cancer. 2010
PubMed ID: 20432164
-
Methylselenocysteine resets the rhythmic expression of circadian and growth-regulatory genes disrupted by nitrosomethylurea in vivo.
Fang MZ, Zhang X, Zarbl H
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20424134
-
Sorafenib in patients with advanced non-small cell lung cancer that harbor K-ras mutations: a brief report.
Smit EF, Dingemans AM, Thunnissen FB, Hochstenbach MM, van Suylen RJ, Postmus PE
J Thorac Oncol. 2010
PubMed ID: 20421765
-
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Bassères DS, Ebbs A, Levantini E, Baldwin AS
Cancer Res. 2010
PubMed ID: 20406971
-
KRAS mutations in Slovene patients with colorectal cancer: frequency, distribution and correlation with the response to treatment.
Licar A, Cerkovnik P, Ocvirk J, Novakovic S
Int J Oncol. 2010
PubMed ID: 20372787
-
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Parsons BL, Marchant-Miros KE, Delongchamp RR, Verkler TL, Patterson TA, McKinzie PB, Kim LT
Cancer Invest. 2010
PubMed ID: 20307197
-
KRAS mutations in traditional serrated adenomas from Korea herald an aggressive phenotype.
Kim KM, Lee EJ, Kim YH, Chang DK, Odze RD
Am J Surg Pathol. 2010
PubMed ID: 20305537
-
Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.
Davidsson J, Paulsson K, Lindgren D, Lilljebjörn H, Chaplin T, Forestier E, Andersen MK, Nordgren A, Rosenquist R, Fioretos T, Young BD, Johansson B
Leukemia. 2010
PubMed ID: 20237506
-
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.
Onitsuka T, Uramoto H, Ono K, Takenoyama M, Hanagiri T, Oyama T, Izumi H, Kohno K, Yasumoto K
J Thorac Oncol. 2010
PubMed ID: 20150826
-
KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications.
Italiano A, Hostein I, Soubeyran I, Fabas T, Benchimol D, Evrard S, Gugenheim J, Becouarn Y, Brunet R, Fonck M, François E, Saint-Paul MC, Pedeutour F
Ann Surg Oncol. 2010
PubMed ID: 20049644
-
The frequency of KRAS mutation detection in human colon carcinoma is influenced by the sensitivity of assay methodology: a comparison between direct sequencing and real-time PCR.
Kobunai T, Watanabe T, Yamamoto Y, Eshima K
Biochem Biophys Res Commun. 2010
PubMed ID: 20361930
-
The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.
de la Vega M, Burrows JF, McFarlane C, Govender U, Scott CJ, Johnston JA
J Biol Chem. 2010
PubMed ID: 20147298
-
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer.
Oliver TG, Mercer KL, Sayles LC, Burke JR, Mendus D, Lovejoy KS, Cheng MH, Subramanian A, Mu D, Powers S, Crowley D, Bronson RT, Whittaker CA, Bhutkar A, Lippard SJ, Golub T, Thomale J, Jacks T, Sweet-Cordero EA
Genes Dev. 2010
PubMed ID: 20395368
-
RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant.
Ricci C, Fermo E, Corti S, Molteni M, Faricciotti A, Cortelezzi A, Lambertenghi Deliliers G, Beran M, Onida F
Clin Cancer Res. 2010
PubMed ID: 20371679
-
Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
Liu M, Sjogren AK, Karlsson C, Ibrahim MX, Andersson KM, Olofsson FJ, Wahlstrom AM, Dalin M, Yu H, Chen Z, Yang SH, Young SG, Bergo MO
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20308544
-
The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer.
Gasull M, Porta M, Pumarega J, Vioque J, de Basea MB, Puigdomènech E, Morales E, Grimalt JO, Malats N
Chemosphere. 2010
PubMed ID: 20350743
-
Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.
Dineen SP, Roland CL, Greer R, Carbon JG, Toombs JE, Gupta P, Bardeesy N, Sun H, Williams N, Minna JD, Brekken RA
Cancer Res. 2010
PubMed ID: 20332237
-
KRAS and BRAF mutations in prostate carcinomas of Chinese patients.
Shen Y, Lu Y, Yin X, Zhu G, Zhu J
Cancer Genet Cytogenet. 2010
PubMed ID: 20303012
-
Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development.
Pan Y, Carbe C, Powers A, Feng GS, Zhang X
Development. 2010
PubMed ID: 20215346
-
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
Luo F, Ye H, Hamoudi R, Dong G, Zhang W, Patek CE, Poulogiannis G, Arends MJ
J Pathol. 2010
PubMed ID: 20087880
-
Distinct populations of metastases-enabling myeloid cells expand in the liver of mice harboring invasive and preinvasive intra-abdominal tumor.
Connolly MK, Mallen-St Clair J, Bedrosian AS, Malhotra A, Vera V, Ibrahim J, Henning J, Pachter HL, Bar-Sagi D, Frey AB, Miller G
J Leukoc Biol. 2010
PubMed ID: 20042467
-
KRAS mutation in colon cancer: a marker of resistance to EGFR-I therapy.
Siddiqui AD, Piperdi B
Ann Surg Oncol. 2010
PubMed ID: 19936839
-
Mitogen-activated protein kinase phosphatase-1 (MKP-1) impairs the response to anti-epidermal growth factor receptor (EGFR) antibody cetuximab in metastatic colorectal cancer patients.
Montagut C, Iglesias M, Arumi M, Bellosillo B, Gallen M, Martinez-Fernandez A, Martinez-Aviles L, Cañadas I, Dalmases A, Moragon E, Lema L, Serrano S, Rovira A, Rojo F, Bellmunt J, Albanell J
Br J Cancer. 2010
PubMed ID: 20234366
-
KRAS mutation status in primary nonsmall cell lung cancer and matched metastases.
Cortot AB, Italiano A, Burel-Vandenbos F, Martel-Planche G, Hainaut P
Cancer. 2010
PubMed ID: 20336783
-
TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity.
Liang MC, Ma J, Chen L, Kozlowski P, Qin W, Li D, Goto J, Shimamura T, Hayes DN, Meyerson M, Kwiatkowski DJ, Wong KK
Oncogene. 2010
PubMed ID: 19966866
-
Investigation of gene dosage imbalances in patients with Noonan syndrome using multiplex ligation-dependent probe amplification analysis.
Nyström AM, Ekvall S, Thuresson AC, Denayer E, Legius E, Kamali-Moghaddam M, Westermark B, Annerén G, Bondeson ML
Eur J Med Genet. 2010
PubMed ID: 20302979
-
Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development.
Cai Z, Feng GS, Zhang X
J Neurosci. 2010
PubMed ID: 20237281
-
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M
EMBO J. 2010
PubMed ID: 20150892
-
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20194733
-
Phenotype-assisted transcriptome analysis identifies FOXM1 downstream from Ras-MKK3-p38 to regulate in vitro cellular invasion.
Behren A, Mühlen S, Acuna Sanhueza GA, Schwager C, Plinkert PK, Huber PE, Abdollahi A, Simon C
Oncogene. 2010
PubMed ID: 20023695
-
Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.
Segat L, Brandão LA, Guimarães RL, Pontillo A, Athanasakis E, de Oliveira RM, Arraes LC, de Lima Filho JL, Crovella S
Vaccine. 2010
PubMed ID: 20056178
-
De novo resistance to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutation-positive patients with non-small cell lung cancer.
Takeda M, Okamoto I, Fujita Y, Arao T, Ito H, Fukuoka M, Nishio K, Nakagawa K
J Thorac Oncol. 2010
PubMed ID: 20186026
-
Clinicopathologic features of non-small-cell lung cancer with EML4-ALK fusion gene.
Takahashi T, Sonobe M, Kobayashi M, Yoshizawa A, Menju T, Nakayama E, Mino N, Iwakiri S, Sato K, Miyahara R, Okubo K, Manabe T, Date H
Ann Surg Oncol. 2010
PubMed ID: 20183914
-
H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.
Ichise T, Yoshida N, Ichise H
Development. 2010
PubMed ID: 20179099
-
Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
Giovannetti E, Zucali PA, Peters GJ, Cortesi F, D'Incecco A, Smit EF, Falcone A, Burgers JA, Santoro A, Danesi R, Giaccone G, Tibaldi C
Mol Cancer Ther. 2010
PubMed ID: 20159991
-
Identification of histologically distinct conventional adenomas that arise predominately in patients with sessile serrated adenomas.
Pai RK, Mackinnon AC, Joseph L, Noffsinger A, Hart J
Am J Surg Pathol. 2010
PubMed ID: 20118768
-
Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a phase I dose-escalation study.
Tabernero J, Cervantes A, Rivera F, Martinelli E, Rojo F, von Heydebreck A, Macarulla T, Rodriguez-Braun E, Eugenia Vega-Villegas M, Senger S, Ramos FJ, Roselló S, Celik I, Stroh C, Baselga J, Ciardiello F
J Clin Oncol. 2010
PubMed ID: 20100964
-
Are there imaging characteristics associated with epidermal growth factor receptor and KRAS mutations in patients with adenocarcinoma of the lung with bronchioloalveolar features?
Glynn C, Zakowski MF, Ginsberg MS
J Thorac Oncol. 2010
PubMed ID: 20087229
-
KRAS mutational status assessment in patients with metastatic colorectal cancer: are the clinical implications so clear?
Hebbar M, Fournier P, Romano O
Eur J Cancer Care (Engl). 2010
PubMed ID: 19702696
-
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
Calvisi DF, Pinna F, Ladu S, Muroni MR, Frau M, Demartis I, Tomasi ML, Sini M, Simile MM, Seddaiu MA, Feo F, Pascale RM
Int J Cancer. 2010
PubMed ID: 19533683
-
Genetic modulation of the Let-7 microRNA binding to KRAS 3'-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab-irinotecan.
Graziano F, Canestrari E, Loupakis F, Ruzzo A, Galluccio N, Santini D, Rocchi M, Vincenzi B, Salvatore L, Cremolini C, Spoto C, Catalano V, D'Emidio S, Giordani P, Tonini G, Falcone A, Magnani M
Pharmacogenomics J. 2010
PubMed ID: 20177422
-
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer.
Khambata-Ford S, Harbison CT, Hart LL, Awad M, Xu LA, Horak CE, Dakhil S, Hermann RC, Lynch TJ, Weber MR
J Clin Oncol. 2010
PubMed ID: 20100958
-
Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.
Zlobec I, Kovac M, Erzberger P, Molinari F, Bihl MP, Rufle A, Foerster A, Frattini M, Terracciano L, Heinimann K, Lugli A
Int J Cancer. 2010
PubMed ID: 20162668
-
Potential clinical significance of a plasma-based KRAS mutation analysis in patients with advanced non-small cell lung cancer.
Wang S, An T, Wang J, Zhao J, Wang Z, Zhuo M, Bai H, Yang L, Zhang Y, Wang X, Duan J, Wang Y, Guo Q, Wu M
Clin Cancer Res. 2010
PubMed ID: 20145159
-
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial.
Douillard JY, Shepherd FA, Hirsh V, Mok T, Socinski MA, Gervais R, Liao ML, Bischoff H, Reck M, Sellers MV, Watkins CL, Speake G, Armour AA, Kim ES
J Clin Oncol. 2010
PubMed ID: 20038723
-
Cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric cancer: a phase II study of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
Lordick F, Luber B, Lorenzen S, Hegewisch-Becker S, Folprecht G, Wöll E, Decker T, Endlicher E, Röthling N, Schuster T, Keller G, Fend F, Peschel C
Br J Cancer. 2010
PubMed ID: 20068568
-
A novel E1B-55kD-deleted oncolytic adenovirus carrying mutant KRAS-regulated hdm2 transgene exerts specific antitumor efficacy on colorectal cancer cells.
Liu CC, Liu JH, Wu SC, Yen CC, Chen WS, Tsai YC
Mol Cancer Ther. 2010
PubMed ID: 20124454
-
Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination.
Mordant P, Loriot Y, Leteur C, Calderaro J, Bourhis J, Wislez M, Soria JC, Deutsch E
Mol Cancer Ther. 2010
PubMed ID: 20124452
-
The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers.
Fritz JM, Dwyer-Nield LD, Russell BM, Malkinson AM
J Thorac Oncol. 2010
PubMed ID: 20101149
-
Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients.
Chung CH, Seeley EH, Roder H, Grigorieva J, Tsypin M, Roder J, Burtness BA, Argiris A, Forastiere AA, Gilbert J, Murphy B, Caprioli RM, Carbone DP, Cohen EE
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20086114
-
Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.
Houghton AM, Rzymkiewicz DM, Ji H, Gregory AD, Egea EE, Metz HE, Stolz DB, Land SR, Marconcini LA, Kliment CR, Jenkins KM, Beaulieu KA, Mouded M, Frank SJ, Wong KK, Shapiro SD
Nat Med. 2010
PubMed ID: 20081861
-
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.
Morris JP, Cano DA, Sekine S, Wang SC, Hebrok M
J Clin Invest. 2010
PubMed ID: 20071774
-
Genetic and proteomic features associated with survival after treatment with erlotinib in first-line therapy of non-small cell lung cancer in Eastern Cooperative Oncology Group 3503.
Amann JM, Lee JW, Roder H, Brahmer J, Gonzalez A, Schiller JH, Carbone DP
J Thorac Oncol. 2010
PubMed ID: 20035238
-
Activating KRAS mutations and overexpression of epidermal growth factor receptor as independent predictors in metastatic colorectal cancer patients treated with cetuximab.
Yen LC, Uen YH, Wu DC, Lu CY, Yu FJ, Wu IC, Lin SR, Wang JY
Ann Surg. 2010
PubMed ID: 20010090
-
K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
Schimanski CC, Zimmermann T, Schmidtmann I, Gockel I, Lang H, Galle PR, Moehler M, Berger MR
Int J Colorectal Dis. 2010
PubMed ID: 19936766
-
Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.
Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa D, Kawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K
Br J Haematol. 2010
PubMed ID: 19874312
-
Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.
Carbuccia N, Trouplin V, Gelsi-Boyer V, Murati A, Rocquain J, Adélaïde J, Olschwang S, Xerri L, Vey N, Chaffanet M, Birnbaum D, Mozziconacci MJ
Leukemia. 2010
PubMed ID: 19865112
-
Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas.
Dacic S, Shuai Y, Yousem S, Ohori P, Nikiforova M
Mod Pathol. 2010
PubMed ID: 19855375
-
Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer.
Konstantinova D, Kaneva R, Dimitrov R, Savov A, Ivanov S, Dyankova T, Kremensky I, Mitev V
DNA Cell Biol. 2010
PubMed ID: 19839777
-
KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer.
Nash GM, Gimbel M, Cohen AM, Zeng ZS, Ndubuisi MI, Nathanson DR, Ott J, Barany F, Paty PB
Ann Surg Oncol. 2010
PubMed ID: 19813061
-
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080688
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.
Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, Hussain J, Reis-Filho JS, Springer CJ, Pritchard C, Marais R
Cell. 2010
PubMed ID: 20141835
-
Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis.
Liu X, Wang X, Zhang J, Lam EK, Shin VY, Cheng AS, Yu J, Chan FK, Sung JJ, Jin HC
Oncogene. 2010
PubMed ID: 19881551
-
Activated BRAF induces gliomas in mice when combined with Ink4a/Arf loss or Akt activation.
Robinson JP, VanBrocklin MW, Guilbeault AR, Signorelli DL, Brandner S, Holmen SL
Oncogene. 2010
PubMed ID: 19855433
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial.
Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, Klingbiel D, Dietrich D, Biesmans B, Bodoky G, Barone C, Aranda E, Nordlinger B, Cisar L, Labianca R, Cunningham D, Van Cutsem E, Bosman F
J Clin Oncol. 2010
PubMed ID: 20008640
-
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Takahashi H, Ogata H, Nishigaki R, Broide DH, Karin M
Cancer Cell. 2010
PubMed ID: 20129250
-
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer.
Morton JP, Timpson P, Karim SA, Ridgway RA, Athineos D, Doyle B, Jamieson NB, Oien KA, Lowy AM, Brunton VG, Frame MC, Evans TR, Sansom OJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20018721
-
Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients.
Zlobec I, Molinari F, Kovac M, Bihl MP, Altermatt HJ, Diebold J, Frick H, Germer M, Horcic M, Montani M, Singer G, Yurtsever H, Zettl A, Terracciano L, Mazzucchelli L, Saletti P, Frattini M, Heinimann K, Lugli A
Br J Cancer. 2010
PubMed ID: 19935791
-
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Su N, Xu XY, Chen H, Gao WC, Ruan CP, Wang Q, Sun YP
Tohoku J Exp Med. 2010
PubMed ID: 21127395
-
KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice.
Sundström M, Edlund K, Lindell M, Glimelius B, Birgisson H, Micke P, Botling J
BMC Cancer. 2010
PubMed ID: 21122130
-
DNA sequence profiles of the colorectal cancer critical gene set KRAS-BRAF-PIK3CA-PTEN-TP53 related to age at disease onset.
Berg M, Danielsen SA, Ahlquist T, Merok MA, Ågesen TH, Vatn MH, Mala T, Sjo OH, Bakka A, Moberg I, Fetveit T, Mathisen Ø, Husby A, Sandvik O, Nesbakken A, Thiis-Evensen E, Lothe RA
PLoS One. 2010
PubMed ID: 21103049
-
Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes.
Chun SY, Johnson C, Washburn JG, Cruz-Correa MR, Dang DT, Dang LH
Mol Cancer. 2010
PubMed ID: 21073737
-
FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.
Kompier LC, Lurkin I, van der Aa MN, van Rhijn BW, van der Kwast TH, Zwarthoff EC
PLoS One. 2010
PubMed ID: 21072204
-
KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers.
Velho S, Corso G, Oliveíra C, Seruca R
Adv Cancer Res. 2010
PubMed ID: 21070916
-
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo.
Mazur PK, Grüner BM, Nakhai H, Sipos B, Zimber-Strobl U, Strobl LJ, Radtke F, Schmid RM, Siveke JT
PLoS One. 2010
PubMed ID: 21042537
-
Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin.
Pinheiro M, Ahlquist T, Danielsen SA, Lind GE, Veiga I, Pinto C, Costa V, Afonso L, Sousa O, Fragoso M, Santos L, Henrique R, Lopes P, Lopes C, Lothe RA, Teixeira MR
BMC Cancer. 2010
PubMed ID: 20979647
-
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Nanda MS, Sameer AS, Syeed N, Shah ZA, Murtaza I, Siddiqi MA, Ali A
Urol J. 2010
PubMed ID: 20845292
-
Suppression of lung tumorigenesis by leucine zipper/EF hand-containing transmembrane-1.
Hwang SK, Piao L, Lim HT, Minai-Tehrani A, Yu KN, Ha YC, Chae CH, Lee KH, Beck GR, Park J, Cho MH
PLoS One. 2010
PubMed ID: 20824095
-
Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases.
Sen M, Ozdemir O, Turan M, Arici S, Yildiz F, Koksal B, Goze F
Intern Med. 2010
PubMed ID: 20686305
-
Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias.
Rocquain J, Carbuccia N, Trouplin V, Raynaud S, Murati A, Nezri M, Tadrist Z, Olschwang S, Vey N, Birnbaum D, Gelsi-Boyer V, Mozziconacci MJ
BMC Cancer. 2010
PubMed ID: 20678218
-
Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.
Bavi P, Prabhakaran SE, Abubaker J, Qadri Z, George T, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Hussain AR, Uddin S, Al-Kuraya KS
Mol Cancer. 2010
PubMed ID: 20673328
-
Chronic pancreatitis in mice by treatment with choline-deficient ethionine-supplemented diet.
Ida S, Ohmuraya M, Hirota M, Ozaki N, Hiramatsu S, Uehara H, Takamori H, Araki K, Baba H, Yamamura K
Exp Anim. 2010
PubMed ID: 20660988
-
Fusion of EML4 and ALK is associated with development of lung adenocarcinomas lacking EGFR and KRAS mutations and is correlated with ALK expression.
Zhang X, Zhang S, Yang X, Yang J, Zhou Q, Yin L, An S, Lin J, Chen S, Xie Z, Zhu M, Zhang X, Wu YL
Mol Cancer. 2010
PubMed ID: 20624322
-
Clinical relevance of KRAS in human cancers.
Jancík S, Drábek J, Radzioch D, Hajdúch M
J Biomed Biotechnol. 2010
PubMed ID: 20617134
-
Comparison of two different screening methods for the KRAS mutation in colorectal cancer.
Er TK, Chang YS, Yeh KT, Chang TJ, Chang JG
Clin Lab. 2010
PubMed ID: 20575464
-
SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene.
Sameer AS, Chowdri NA, Syeed N, Banday MZ, Shah ZA, Siddiqi MA
BMC Cancer. 2010
PubMed ID: 20565773
-
Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells.
Zeng M, Kikuchi H, Pino MS, Chung DC
PLoS One. 2010
PubMed ID: 20532039
-
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Van Damme N, Deron P, Van Roy N, Demetter P, Bols A, Van Dorpe J, Baert F, Van Laethem JL, Speleman F, Pauwels P, Peeters M
BMC Cancer. 2010
PubMed ID: 20459770
-
Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?
van Roon EH, van Puijenbroek M, Middeldorp A, van Eijk R, de Meijer EJ, Erasmus D, Wouters KA, van Engeland M, Oosting J, Hes FJ, Tops CM, van Wezel T, Boer JM, Morreau H
BMC Cancer. 2010
PubMed ID: 20444249
-
A comparability study of 5 commercial KRAS tests.
Oliner K, Juan T, Suggs S, Wolf M, Sarosi I, Freeman DJ, Gyuris T, Baron W, Bakker A, Parker A, Patterson SD
Diagn Pathol. 2010
PubMed ID: 20398393
-
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer.
Sánchez-Muñoz A, Gallego E, de Luque V, Pérez-Rivas LG, Vicioso L, Ribelles N, Lozano J, Alba E
BMC Cancer. 2010
PubMed ID: 20385028
-
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined ApcMin and KRASV12 mutations.
Nandan MO, Ghaleb AM, McConnell BB, Patel NV, Robine S, Yang VW
Mol Cancer. 2010
PubMed ID: 20298593
-
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Naguib A, Mitrou PN, Gay LJ, Cooke JC, Luben RN, Ball RY, McTaggart A, Arends MJ, Rodwell SA
BMC Cancer. 2010
PubMed ID: 20233436
-
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Yunxia Z, Jun C, Guanshan Z, Yachao L, Xueke Z, Jin L
BMC Med Genet. 2010
PubMed ID: 20184776
-
Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.
Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T, Nakamura T, Toguchida J
Anticancer Res. 2010
PubMed ID: 20150643
-
KRAS mutation screening in colorectal cancer: From paper to practice.
Fakih MM
Clin Colorectal Cancer. 2010
PubMed ID: 20100685
-
Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes.
Lurkin I, Stoehr R, Hurst CD, van Tilborg AA, Knowles MA, Hartmann A, Zwarthoff EC
PLoS One. 2010
PubMed ID: 20098682
-
Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.
Fuentes-Calvo I, Blázquez-Medela AM, Santos E, López-Novoa JM, Martínez-Salgado C
PLoS One. 2010
PubMed ID: 20090846
-
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas.
Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, Heyer J
Nat Biotechnol. 2010
PubMed ID: 20023657
-
Primary oncocytic adenocarcinomas of the lung: a clinicopathologic, immunohistochemical, and molecular biologic analysis of 16 cases.
Solis LM, Raso MG, Kalhor N, Behrens C, Wistuba II, Moran CA
Am J Clin Pathol. 2010
PubMed ID: 20023269
-
KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy.
Gaedcke J, Grade M, Jung K, Schirmer M, Jo P, Obermeyer C, Wolff HA, Herrmann MK, Beissbarth T, Becker H, Ried T, Ghadimi M
Radiother Oncol. 2010
PubMed ID: 19913317
-
AKT1 pleckstrin homology domain E17K activating mutation in endometrial carcinoma.
Cohen Y, Shalmon B, Korach J, Barshack I, Fridman E, Rechavi G
Gynecol Oncol. 2010
PubMed ID: 19853286
-
Use of epidermal growth factor receptor/Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: comparison with clinical guidelines.
Girard N, Deshpande C, Azzoli CG, Rusch VW, Travis WD, Ladanyi M, Pao W
Chest. 2010
PubMed ID: 19376842
-
LIN28B confers radio-resistance through the posttranscriptional control of KRAS.
Jeong SH, Wu HG, Park WY
Exp Mol Med. 2009
PubMed ID: 19745602
-
Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase.
Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvili M, Koshoridze N, Mikeladze D
Behav Brain Res. 2009
PubMed ID: 19616040
-
Phase II study of preoperative gefitinib in clinical stage I non-small-cell lung cancer.
Lara-Guerra H, Waddell TK, Salvarrey MA, Joshua AM, Chung CT, Paul N, Boerner S, Sakurada A, Ludkovski O, Ma C, Squire J, Liu G, Shepherd FA, Tsao MS, Leighl NB
J Clin Oncol. 2009
PubMed ID: 19884551
-
KRAS mutations and resistance to EGFR-TKIs treatment in patients with non-small cell lung cancer: A meta-analysis of 22 studies.
Mao C, Qiu LX, Liao RY, Du FB, Ding H, Yang WC, Li J, Chen Q
Lung Cancer. 2009
PubMed ID: 20022659
-
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers.
Jin G, Kim MJ, Jeon HS, Choi JE, Kim DS, Lee EB, Cha SI, Yoon GS, Kim CH, Jung TH, Park JY
Lung Cancer. 2009
PubMed ID: 20018398
-
Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer.
Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, Lecomte T, Rougier P, Lievre A, Landi B, Boige V, Ducreux M, Ychou M, Bibeau F, Bouché O, Reid J, Stone S, Penault-Llorca F
J Clin Oncol. 2009
PubMed ID: 19884556
-
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial.
Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, Taylor G, Barrett JH, Quirke P
J Clin Oncol. 2009
PubMed ID: 19884549
-
Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer.
Dobrzycka B, Terlikowski SJ, Mazurek A, Kowalczuk O, Niklinska W, Chyczewski L, Kulikowski M
Int J Cancer. 2009
PubMed ID: 19960433
-
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803.
Ogino S, Meyerhardt JA, Irahara N, Niedzwiecki D, Hollis D, Saltz LB, Mayer RJ, Schaefer P, Whittom R, Hantel A, Benson AB, Goldberg RM, Bertagnolli MM, Fuchs CS, Cancer and Leukemia Group B, North Central Cancer Treatment Group, Canadian Cancer Society Research Institute, Southwest Oncology Group
Clin Cancer Res. 2009
PubMed ID: 19934290
-
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice.
Santos AM, Jung J, Aziz N, Kissil JL, Puré E
J Clin Invest. 2009
PubMed ID: 19920354
-
Dicer1 functions as a haploinsufficient tumor suppressor.
Kumar MS, Pester RE, Chen CY, Lane K, Chin C, Lu J, Kirsch DG, Golub TR, Jacks T
Genes Dev. 2009
PubMed ID: 19903759
-
Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.
Abubaker J, Bavi P, Al-Haqawi W, Sultana M, Al-Harbi S, Al-Sanea N, Abduljabbar A, Ashari LH, Alhomoud S, Al-Dayel F, Uddin S, Al-Kuraya KS
J Pathol. 2009
PubMed ID: 19824059
-
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment?
Zampino MG, Magni E, Sonzogni A, Renne G
Cancer Chemother Pharmacol. 2009
PubMed ID: 19727729
-
Novel multiple, monoallelic KRAS mutations at codon 12 and 13.
Keller G, Geist B, Slotta-Huspenina J, Langer R, Nagl F, Fend F, Höfler H, Perren A
Int J Cancer. 2009
PubMed ID: 19521964
-
KRAS Status in Patients With Colorectal Cancer Peritoneal Carcinomatosis and Its Impact on Outcome.
Gillern SM, Chua TC, Stojadinovic A, Esquivel J
Am J Clin Oncol. 2009
PubMed ID: 19952717
-
PTEN dosage is essential for neurofibroma development and malignant transformation.
Gregorian C, Nakashima J, Dry SM, Nghiemphu PL, Smith KB, Ao Y, Dang J, Lawson G, Mellinghoff IK, Mischel PS, Phelps M, Parada LF, Liu X, Sofroniew MV, Eilber FC, Wu H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19846776
-
PIK3CA mutations predict local recurrences in rectal cancer patients.
He Y, Van't Veer LJ, Mikolajewska-Hanclich I, van Velthuysen ML, Zeestraten EC, Nagtegaal ID, van de Velde CJ, Marijnen CA
Clin Cancer Res. 2009
PubMed ID: 19903786
-
EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy.
Italiano A, Cortot AB, Ilie M, Martel-Planche G, Fabas T, Pop D, Mouroux J, Hofman V, Hofman P, Pedeutour F
Int J Cancer. 2009
PubMed ID: 19681124
-
The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.
Borie C, Colas C, Dartigues P, Lazure T, Rince P, Buhard O, Folliot P, Chalastanis A, Muleris M, Hamelin R, Mercier D, Oliveira C, Seruca R, Chadburn A, Leblond V, Barete S, Gaïdano G, Martin A, Gaulard P, Fléjou JF, Raphael M, Duval A
Int J Cancer. 2009
PubMed ID: 19551857
-
Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis.
Zlobec I, Bihl MP, Schwarb H, Terracciano L, Lugli A
Int J Cancer. 2009
PubMed ID: 19908233
-
Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.
Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T
Cancer Cell. 2009
PubMed ID: 19878870
-
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF, Schinzel AC, Sandy P, Meylan E, Scholl C, Fröhling S, Chan EM, Sos ML, Michel K, Mermel C, Silver SJ, Weir BA, Reiling JH, Sheng Q, Gupta PB, Wadlow RC, Le H, Hoersch S, Wittner BS, Ramaswamy S, Livingston DM, Sabatini DM, Meyerson M, Thomas RK, Lander ES, Mesirov JP, Root DE, Gilliland DG, Jacks T, Hahn WC
Nature. 2009
PubMed ID: 19847166
-
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.
Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C, Jacks T
Nature. 2009
PubMed ID: 19847165
-
[Effect of KRAS mutation on efficacy of Cetuximab combined with chemotherapy in advanced colorectal cancer patients]
Pu XX, Deng YH, Xu F, Xiao J, Guo HQ, Huang H, Tian Y, He YJ, Lin TY
Zhonghua Wei Chang Wai Ke Za Zhi. 2009
PubMed ID: 19921572
-
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
Oikonomou E, Makrodouli E, Evagelidou M, Joyce T, Probert L, Pintzas A
Neoplasia. 2009
PubMed ID: 19881948
-
Oncogenic KRAS and BRAF differentially regulate hypoxia-inducible factor-1alpha and -2alpha in colon cancer.
Kikuchi H, Pino MS, Zeng M, Shirasawa S, Chung DC
Cancer Res. 2009
PubMed ID: 19843849
-
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation.
Bornstein S, White R, Malkoski S, Oka M, Han G, Cleaver T, Reh D, Andersen P, Gross N, Olson S, Deng C, Lu SL, Wang XJ
J Clin Invest. 2009
PubMed ID: 19841536
-
A conditional mouse model for human MUC1-positive endometriosis shows the presence of anti-MUC1 antibodies and Foxp3+ regulatory T cells.
Budiu RA, Diaconu I, Chrissluis R, Dricu A, Edwards RP, Vlad AM
Dis Model Mech. 2009
PubMed ID: 19841240
-
A multicenter blinded study to evaluate KRAS mutation testing methodologies in the clinical setting.
Whitehall V, Tran K, Umapathy A, Grieu F, Hewitt C, Evans TJ, Ismail T, Li WQ, Collins P, Ravetto P, Leggett B, Salto-Tellez M, Soong R, Fox S, Scott RJ, Dobrovic A, Iacopetta B
J Mol Diagn. 2009
PubMed ID: 19815694
-
Ras classical effectors: new tales from in silico complexes.
Fuentes G, Valencia A
Trends Biochem Sci. 2009
PubMed ID: 19801192
-
In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations.
Porta M, López T, Pumarega J, Jariod M, Crous-Bou M, Marco E, Rifà J, Grimalt JO, Malats N, Real FX, PANKRAS II Study Group
Mutagenesis. 2009
PubMed ID: 19797353
-
Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice.
Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF
Carcinogenesis. 2009
PubMed ID: 19793800
-
The status of KRAS mutations in patients with non-small cell lung cancers from mainland China.
Li M, Liu L, Liu Z, Yue S, Zhou L, Zhang Q, Cheng S, Li RW, Smith PN, Lu S
Oncol Rep. 2009
PubMed ID: 19787214
-
A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers.
Nosho K, Kure S, Irahara N, Shima K, Baba Y, Spiegelman D, Meyerhardt JA, Giovannucci EL, Fuchs CS, Ogino S
Gastroenterology. 2009
PubMed ID: 19686742
-
RAS signaling dysregulation in human embryonal Rhabdomyosarcoma.
Martinelli S, McDowell HP, Vigne SD, Kokai G, Uccini S, Tartaglia M, Dominici C
Genes Chromosomes Cancer. 2009
PubMed ID: 19681119
-
Integrative approach for prioritizing cancer genes in sporadic colon cancer.
Reid JF, Gariboldi M, Sokolova V, Capobianco P, Lampis A, Perrone F, Signoroni S, Costa A, Leo E, Pilotti S, Pierotti MA
Genes Chromosomes Cancer. 2009
PubMed ID: 19672874
-
TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.
Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, Andera L, Zografos G, Pintzas A
Int J Cancer. 2009
PubMed ID: 19637313
-
MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer.
Paule B, Castagne V, Picard V, Saffroy R, Adam R, Guettier C, Farinotti R, Bonhomme-Faivre L
Med Oncol. 2009
PubMed ID: 19862647
-
KRAS mutation, KRAS-LCS6 polymorphism, and non-small cell lung cancer.
Nelson HH, Christensen BC, Plaza SL, Wiencke JK, Marsit CJ, Kelsey KT
Lung Cancer. 2009
PubMed ID: 19854534
-
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Kalikaki A, Koutsopoulos A, Hatzidaki D, Trypaki M, Kontopodis E, Stathopoulos E, Mavroudis D, Georgoulias V, Voutsina A
Lung Cancer. 2009
PubMed ID: 19854533
-
Nf1 deficiency cooperates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
Cutts BA, Sjogren AK, Andersson KM, Wahlstrom AM, Karlsson C, Swolin B, Bergo MO
Blood. 2009
PubMed ID: 19710506
-
Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab.
Jacobs B, De Roock W, Piessevaux H, Van Oirbeek R, Biesmans B, De Schutter J, Fieuws S, Vandesompele J, Peeters M, Van Laethem JL, Humblet Y, Pénault-Llorca F, De Hertogh G, Laurent-Puig P, Van Cutsem E, Tejpar S
J Clin Oncol. 2009
PubMed ID: 19738126
-
RAS and CSF3R mutations in severe congenital neutropenia.
Germeshausen M, Kratz CP, Ballmaier M, Welte K
Blood. 2009
PubMed ID: 19833857
-
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.
Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA
Cancer Res. 2009
PubMed ID: 19789336
-
Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer.
Kelly-Spratt KS, Philipp-Staheli J, Gurley KE, Hoon-Kim K, Knoblaugh S, Kemp CJ
Oncogene. 2009
PubMed ID: 19648963
-
K-ras expression--marker of dysplasia and cancer.
Bleotu C, Pleşa A, Botezatu A, Goia C, Drăguţel R, Socolov D, Corniţescu F, Teleman S, Anton G
Roum Arch Microbiol Immunol. 2009
PubMed ID: 20583472
-
Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer.
Kubo T, Kuroda Y, Kokubu A, Hosoda F, Arai Y, Hiraoka N, Hirohashi S, Shibata T
Pancreas. 2009
PubMed ID: 19893451
-
In situ evidence of KRAS amplification and association with increased p21 levels in non-small cell lung carcinoma.
Wagner PL, Perner S, Rickman DS, LaFargue CJ, Kitabayashi N, Johnstone SF, Weir BA, Meyerson M, Altorki NK, Rubin MA
Am J Clin Pathol. 2009
PubMed ID: 19762526
-
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP
Cancer Res. 2009
PubMed ID: 19738040
-
Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: a population-based prospective study.
Boldrini L, Alì G, Gisfredi S, Ursino S, Baldini E, Melfi F, Lucchi M, Comin CE, Maddau C, Tibaldi C, Camacci T, Servadio A, Mussi A, Fontanini G
Oncol Rep. 2009
PubMed ID: 19724844
-
A Cre/LoxP conditional luciferase reporter transgenic mouse for bioluminescence monitoring of tumorigenesis.
Woolfenden S, Zhu H, Charest A
Genesis. 2009
PubMed ID: 19603508
-
Cetuximab plus cisplatin-5-fluorouracil versus cisplatin-5-fluorouracil alone in first-line metastatic squamous cell carcinoma of the esophagus: a randomized phase II study of the Arbeitsgemeinschaft Internistische Onkologie.
Lorenzen S, Schuster T, Porschen R, Al-Batran SE, Hofheinz R, Thuss-Patience P, Moehler M, Grabowski P, Arnold D, Greten T, Müller L, Röthling N, Peschel C, Langer R, Lordick F
Ann Oncol. 2009
PubMed ID: 19549707
-
Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.
Rapozo DC, Grinmann AB, Carvalho AT, de Souza HS, Soares-Lima SC, de Almeida Simão T, de Paiva D, Abby F, Albano RM, Pinto LF
Int J Colorectal Dis. 2009
PubMed ID: 19543899
-
Prognostic significance and molecular associations of 18q loss of heterozygosity: a cohort study of microsatellite stable colorectal cancers.
Ogino S, Nosho K, Irahara N, Shima K, Baba Y, Kirkner GJ, Meyerhardt JA, Fuchs CS
J Clin Oncol. 2009
PubMed ID: 19704056
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Willson JK, Markowitz S, Zhou S, Diaz LA, Velculescu VE, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N
Science. 2009
PubMed ID: 19661383
-
Ethnic differences and functional analysis of MET mutations in lung cancer.
Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R
Clin Cancer Res. 2009
PubMed ID: 19723643
-
Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer.
Chua W, Goldstein D, Lee CK, Dhillon H, Michael M, Mitchell P, Clarke SJ, Iacopetta B
Br J Cancer. 2009
PubMed ID: 19672255
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK.
Shaw AT, Yeap BY, Mino-Kenudson M, Digumarthy SR, Costa DB, Heist RS, Solomon B, Stubbs H, Admane S, McDermott U, Settleman J, Kobayashi S, Mark EJ, Rodig SJ, Chirieac LR, Kwak EL, Lynch TJ, Iafrate AJ
J Clin Oncol. 2009
PubMed ID: 19667264
-
A comparison of EGFR and KRAS status in primary lung carcinoma and matched metastases.
Monaco SE, Nikiforova MN, Cieply K, Teot LA, Khalbuss WE, Dacic S
Hum Pathol. 2009
PubMed ID: 19740513
-
MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa.
Hawkins NJ, Lee JH, Wong JJ, Kwok CT, Ward RL, Hitchins MP
Mod Pathol. 2009
PubMed ID: 19734844
-
KRAS Mutation Correlates With Accelerated Metastatic Progression in Patients With Colorectal Liver Metastases.
Nash GM, Gimbel M, Shia J, Nathanson DR, Ndubuisi MI, Zeng ZS, Kemeny N, Paty PB
Ann Surg Oncol. 2009
PubMed ID: 19727962
-
The role of MAPK and FAS death receptor pathways in testicular germ cell apoptosis induced by lead.
Dong S, Liang D, An N, Jia L, Shan Y, Chen C, Sun K, Niu F, Li H, Fu S
Acta Biochim Biophys Sin (Shanghai). 2009
PubMed ID: 19727529
-
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes.
Porta M, Crous-Bou M, Wark PA, Vineis P, Real FX, Malats N, Kampman E
Mutat Res. 2009
PubMed ID: 19651236
-
Mutation detection of KRAS by high-resolution melting analysis in Chinese with gastric cancer.
Liu ZM, Liu LN, Li M, Zhang QP, Cheng SH, Lu S
Oncol Rep. 2009
PubMed ID: 19639197
-
Concomitant mutations and splice variants in KRAS and BRAF demonstrate complex perturbation of the Ras/Raf signalling pathway in advanced colorectal cancer.
Seth R, Crook S, Ibrahem S, Fadhil W, Jackson D, Ilyas M
Gut. 2009
PubMed ID: 19474002
-
Prognostic value of KRAS mutations and Ki-67 expression in stage I lung adenocarcinomas.
Woo T, Okudela K, Yazawa T, Wada N, Ogawa N, Ishiwa N, Tajiri M, Rino Y, Kitamura H, Masuda M
Lung Cancer. 2009
PubMed ID: 19162366
-
Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.
Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C
Cancer Lett. 2009
PubMed ID: 19344998
-
Developmental and species-divergent globin switching are driven by BCL11A.
Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH
Nature. 2009
PubMed ID: 19657335
-
KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer.
Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, Santini D, Masi G, Stasi I, Canestrari E, Rulli E, Floriani I, Bencardino K, Galluccio N, Catalano V, Tonini G, Magnani M, Fontanini G, Basolo F, Falcone A, Graziano F
Br J Cancer. 2009
PubMed ID: 19603018
-
The hypervariable region of K-Ras4B is responsible for its specific interactions with calmodulin.
Abraham SJ, Nolet RP, Calvert RJ, Anderson LM, Gaponenko V
Biochemistry. 2009
PubMed ID: 19583261
-
Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells.
Fan HY, Liu Z, Paquet M, Wang J, Lydon JP, DeMayo FJ, Richards JS
Cancer Res. 2009
PubMed ID: 19679546
-
Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials.
Jackman DM, Miller VA, Cioffredi LA, Yeap BY, Jänne PA, Riely GJ, Ruiz MG, Giaccone G, Sequist LV, Johnson BE
Clin Cancer Res. 2009
PubMed ID: 19671843
-
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.
Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A
Pathol Res Pract. 2009
PubMed ID: 19679400
-
Microsatellite instability and survival in rectal cancer.
Samowitz WS, Curtin K, Wolff RK, Tripp SR, Caan BJ, Slattery ML
Cancer Causes Control. 2009
PubMed ID: 19669908
-
Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer.
Souglakos J, Philips J, Wang R, Marwah S, Silver M, Tzardi M, Silver J, Ogino S, Hooshmand S, Kwak E, Freed E, Meyerhardt JA, Saridaki Z, Georgoulias V, Finkelstein D, Fuchs CS, Kulke MH, Shivdasani RA
Br J Cancer. 2009
PubMed ID: 19603024
-
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Tsujioka H, Hachisuga T, Fukuoka M, Ueda T, Miyahara D, Horiuchi S, Shirota K, Yoshizato T, Emoto M, Miyamoto S, Kawarabayashi T
Int J Gynecol Cancer. 2009
PubMed ID: 19820367
-
A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans.
Scholtka B, Schneider M, Melcher R, Katzenberger T, Friedrich D, Berghof-Jäger K, Scheppach W, Steinberg P
Cancer Epidemiol. 2009
PubMed ID: 19679059
-
HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice.
Kim WY, Perera S, Zhou B, Carretero J, Yeh JJ, Heathcote SA, Jackson AL, Nikolinakos P, Ospina B, Naumov G, Brandstetter KA, Weigman VJ, Zaghlul S, Hayes DN, Padera RF, Heymach JV, Kung AL, Sharpless NE, Kaelin WG, Wong KK
J Clin Invest. 2009
PubMed ID: 19662677
-
Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras.
Prante O, Maschauer S, Fremont V, Reinfelder J, Stoehr R, Szkudlinski M, Weintraub B, Hartmann A, Kuwert T
J Nucl Med. 2009
PubMed ID: 19652218
-
Genetic and molecular diversity of colon cancer hepatic metastases.
Messick CA, Sanchez J, Dejulius KL, Church JM, Kalady MF
Surgery. 2009
PubMed ID: 19628078
-
Pathogenetic pathways in ovarian endometrioid adenocarcinoma: a molecular study of 29 cases.
Geyer JT, López-García MA, Sánchez-Estevez C, Sarrió D, Moreno-Bueno G, Franceschetti I, Palacios J, Oliva E
Am J Surg Pathol. 2009
PubMed ID: 19542870
-
Molecular analysis of PIK3CA, BRAF, and RAS oncogenes in periampullary and ampullary adenomas and carcinomas.
Schönleben F, Qiu W, Allendorf JD, Chabot JA, Remotti HE, Su GH
J Gastrointest Surg. 2009
PubMed ID: 19440799
-
Detection of EGFR and KRAS Mutations on Trans-Thoracic Needle Aspiration of Lung Nodules by High Resolution Melting Analysis.
Fassina A, Gazziero A, Zardo D, Corradin M, Aldighieri E, Rossi GP
J Clin Pathol. 2009
PubMed ID: 19640859
-
Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients.
Park SR, Kook MC, Choi IJ, Kim CG, Lee JY, Cho SJ, Kim YW, Ryu KW, Lee JH, Lee JS, Park YI, Kim NK
Cancer Chemother Pharmacol. 2009
PubMed ID: 19629485
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
EGFR/KRAS/BRAF mutations in primary lung adenocarcinomas and corresponding locoregional lymph node metastases.
Schmid K, Oehl N, Wrba F, Pirker R, Pirker C, Filipits M
Clin Cancer Res. 2009
PubMed ID: 19584155
-
Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
Chan MK, Ocampo-Hafalla MT, Vartanian V, Jaruga P, Kirkali G, Koenig KL, Brown S, Lloyd RS, Dizdaroglu M, Teebor GW
DNA Repair (Amst). 2009
PubMed ID: 19346169
-
BRAF mutation in metastatic colorectal cancer.
Tol J, Nagtegaal ID, Punt CJ
N Engl J Med. 2009
PubMed ID: 19571295
-
Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice.
Koohdani F, Sasani F, Mohammad K, Mehdipour P
Singapore Med J. 2009
PubMed ID: 19644632
-
Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.
Pesek M, Benesova L, Belsanova B, Mukensnabl P, Bruha F, Minarik M
Anticancer Res. 2009
PubMed ID: 19596959
-
Novel susceptibility loci for second primary tumors/recurrence in head and neck cancer patients: large-scale evaluation of genetic variants.
Wu X, Spitz MR, Lee JJ, Lippman SM, Ye Y, Yang H, Khuri FR, Kim E, Gu J, Lotan R, Hong WK
Cancer Prev Res (Phila Pa). 2009
PubMed ID: 19584075
-
Mutation pattern of K-ras gene in colorectal cancer patients of Kashmir: a report.
Sameer AS, Chowdhri NA, Abdullah S, Shah ZA, Siddiqi MA
Indian J Cancer. 2009
PubMed ID: 19574674
-
A comparison of colon and rectal somatic DNA alterations.
Slattery ML, Curtin K, Wolff RK, Boucher KM, Sweeney C, Edwards S, Caan BJ, Samowitz W
Dis Colon Rectum. 2009
PubMed ID: 19571709
-
V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours.
Agaimy A, Terracciano LM, Dirnhofer S, Tornillo L, Foerster A, Hartmann A, Bihl MP
J Clin Pathol. 2009
PubMed ID: 19561230
-
Detection of KRAS oncogene in peripheral blood as a predictor of the response to cetuximab plus chemotherapy in patients with metastatic colorectal cancer.
Yen LC, Yeh YS, Chen CW, Wang HM, Tsai HL, Lu CY, Chang YT, Chu KS, Lin SR, Wang JY
Clin Cancer Res. 2009
PubMed ID: 19549774
-
KRAS mutation testing in colorectal cancer.
Plesec TP, Hunt JL
Adv Anat Pathol. 2009
PubMed ID: 19546608
-
Pancreatic cancer: molecular pathogenesis and new therapeutic targets.
Wong HH, Lemoine NR
Nat Rev Gastroenterol Hepatol. 2009
PubMed ID: 19506583
-
Somatic alterations, metabolizing genes and smoking in rectal cancer.
Curtin K, Samowitz WS, Wolff RK, Herrick J, Caan BJ, Slattery ML
Int J Cancer. 2009
PubMed ID: 19358278
-
Follow-up study of K-ras mutations in the plasma of patients with pancreatic cancer: correlation with clinical features and carbohydrate antigen 19-9.
Däbritz J, Preston R, Hänfler J, Oettle H
Pancreas. 2009
PubMed ID: 19295453
-
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
de Vogel S, Weijenberg MP, Herman JG, Wouters KA, de Goeij AF, van den Brandt PA, de Bruïne AP, van Engeland M
Ann Oncol. 2009
PubMed ID: 19164452
-
Repeated aerosol delivery of carboxyl-terminal modulator protein suppresses tumor in the lungs of K-rasLA1 mice.
Hwang SK, Lim HT, Minai-Tehrani A, Lee ES, Park J, Park SB, Beck GR, Cho MH
Am J Respir Crit Care Med. 2009
PubMed ID: 19286625
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA
Science. 2009
PubMed ID: 19460966
-
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Singh A, Greninger P, Rhodes D, Koopman L, Violette S, Bardeesy N, Settleman J
Cancer Cell. 2009
PubMed ID: 19477428
-
Endoscopic ultrasound-guided fine-needle aspiration biopsy coupled with KRAS mutation assay to distinguish pancreatic cancer from pseudotumoral chronic pancreatitis.
Bournet B, Souque A, Senesse P, Assenat E, Barthet M, Lesavre N, Aubert A, O'Toole D, Hammel P, Levy P, Ruszniewski P, Bouisson M, Escourrou J, Cordelier P, Buscail L
Endoscopy. 2009
PubMed ID: 19533561
-
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.
Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA
Cancer Res. 2009
PubMed ID: 19487299
-
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.
Loupakis F, Pollina L, Stasi I, Ruzzo A, Scartozzi M, Santini D, Masi G, Graziano F, Cremolini C, Rulli E, Canestrari E, Funel N, Schiavon G, Petrini I, Magnani M, Tonini G, Campani D, Floriani I, Cascinu S, Falcone A
J Clin Oncol. 2009
PubMed ID: 19398573
-
A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers.
Christensen BC, Moyer BJ, Avissar M, Ouellet LG, Plaza SL, McClean MD, Marsit CJ, Kelsey KT
Carcinogenesis. 2009
PubMed ID: 19380522
-
The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras.
Tsang WP, Kwok TT
Carcinogenesis. 2009
PubMed ID: 19372139
-
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Crous-Bou M, Porta M, López T, Jariod M, Malats N, Morales E, Guarner L, Rifà J, Carrato A, Real FX, PANKRAS II Study Group
Environ Mol Mutagen. 2009
PubMed ID: 19326463
-
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Horii J, Hiraoka S, Kato J, Saito S, Harada K, Fujita H, Kaji E, Yamamoto K
Cancer Sci. 2009
PubMed ID: 19302287
-
Lack of KRAS and BRAF mutation in renal cell carcinoma.
Gattenlöhner S, Etschmann B, Riedmiller H, Müller-Hermelink HK
Eur Urol. 2009
PubMed ID: 19282104
-
Mitofusin-2 regulates mitochondrial and endoplasmic reticulum morphology and tethering: the role of Ras.
de Brito OM, Scorrano L
Mitochondrion. 2009
PubMed ID: 19269351
-
Mutational analysis of the BRAF, RAS and EGFR genes in human adrenocortical carcinomas.
Kotoula V, Sozopoulos E, Litsiou H, Fanourakis G, Koletsa T, Voutsinas G, Tseleni-Balafouta S, Mitsiades CS, Wellmann A, Mitsiades N
Endocr Relat Cancer. 2009
PubMed ID: 19190079
-
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ
Cell. 2009
PubMed ID: 19490893
-
Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
Scholl C, Fröhling S, Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG
Cell. 2009
PubMed ID: 19490892
-
Gfi1 integrates progenitor versus granulocytic transcriptional programming.
Horman SR, Velu CS, Chaubey A, Bourdeau T, Zhu J, Paul WE, Gebelein B, Grimes HL
Blood. 2009
PubMed ID: 19346496
-
Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): Study of a comprehensive panel of molecular markers.
Tiseo M, Rossi G, Capelletti M, Sartori G, Spiritelli E, Marchioni A, Bozzetti C, De Palma G, Lagrasta C, Campanini N, Camisa R, Boni L, Franciosi V, Rindi G, Ardizzoni A
Lung Cancer. 2009
PubMed ID: 19473722
-
Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.
Raimondi AR, Molinolo A, Gutkind JS
Cancer Res. 2009
PubMed ID: 19435901
-
Acute pancreatitis markedly accelerates pancreatic cancer progression in mice expressing oncogenic Kras.
Carrière C, Young AL, Gunn JR, Longnecker DS, Korc M
Biochem Biophys Res Commun. 2009
PubMed ID: 19292977
-
PI3K/Akt pathway mutations in Retinoblastoma.
Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe'er J, Goldenberg-Cohen N
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19420344
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations.
Kratz CP, Zampino G, Kriek M, Kant SG, Leoni C, Pantaleoni F, Oudesluys-Murphy AM, Di Rocco C, Kloska SP, Tartaglia M, Zenker M
Am J Med Genet A. 2009
PubMed ID: 19396835
-
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
De Oliveira Duarte Achcar R, Nikiforova MN, Yousem SA
Am J Clin Pathol. 2009
PubMed ID: 19369630
-
PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer.
Prenen H, De Schutter J, Jacobs B, De Roock W, Biesmans B, Claes B, Lambrechts D, Van Cutsem E, Tejpar S
Clin Cancer Res. 2009
PubMed ID: 19366826
-
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.
Winder T, Mündlein A, Rhomberg S, Dirschmid K, Hartmann BL, Knauer M, Drexel H, Wenzl E, De Vries A, Lang A
Oncol Rep. 2009
PubMed ID: 19360305
-
Activation of RAS family genes in urothelial carcinoma.
Boulalas I, Zaravinos A, Karyotis I, Delakas D, Spandidos DA
J Urol. 2009
PubMed ID: 19303097
-
Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors.
Honecker F, Wermann H, Mayer F, Gillis AJ, Stoop H, van Gurp RJ, Oechsle K, Steyerberg E, Hartmann JT, Dinjens WN, Oosterhuis JW, Bokemeyer C, Looijenga LH
J Clin Oncol. 2009
PubMed ID: 19289622
-
Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription.
Paramasivam M, Membrino A, Cogoi S, Fukuda H, Nakagama H, Xodo LE
Nucleic Acids Res. 2009
PubMed ID: 19282454
-
Adenosquamous carcinoma of the pancreas harbors KRAS2, DPC4 and TP53 molecular alterations similar to pancreatic ductal adenocarcinoma.
Brody JR, Costantino CL, Potoczek M, Cozzitorto J, McCue P, Yeo CJ, Hruban RH, Witkiewicz AK
Mod Pathol. 2009
PubMed ID: 19270646
-
TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.
Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM
Gastroenterology. 2009
PubMed ID: 19208363
-
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
Mutational analysis of KRAS, BRAF, and TP53 genes of ovarian serous carcinomas in Korean women.
Cho YH, Kim DY, Kim JH, Kim YM, Kim KR, Nam JH, Kim YT
Yonsei Med J. 2009
PubMed ID: 19430562
-
TP53 mutations predict disease control in metastatic colorectal cancer treated with cetuximab-based chemotherapy.
Oden-Gangloff A, Di Fiore F, Bibeau F, Lamy A, Bougeard G, Charbonnier F, Blanchard F, Tougeron D, Ychou M, Boissière F, Le Pessot F, Sabourin JC, Tuech JJ, Michel P, Frebourg T
Br J Cancer. 2009
PubMed ID: 19367287
-
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
-
Oncogenic Kras requires simultaneous PI3K signaling to induce ERK activation and transform thyroid epithelial cells in vivo.
Miller KA, Yeager N, Baker K, Liao XH, Refetoff S, Di Cristofano A
Cancer Res. 2009
PubMed ID: 19351816
-
KRAS mutations in non-small cell lung cancer.
Riely GJ, Marks J, Pao W
Proc Am Thorac Soc. 2009
PubMed ID: 19349489
-
Significant association between EGFR-mutated lung adenocarcinoma and past illness from gastric cancer or uterine myoma: Its implication in carcinogenesis.
Okudela K, Woo T, Yazawa T, Ogawa N, Tajiri M, Masuda M, Kitamura H
Lung Cancer. 2009
PubMed ID: 19362747
-
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Iacobuzio-Donahue CA, Fu B, Yachida S, Luo M, Abe H, Henderson CM, Vilardell F, Wang Z, Keller JW, Banerjee P, Herman JM, Cameron JL, Yeo CJ, Halushka MK, Eshleman JR, Raben M, Klein AP, Hruban RH, Hidalgo M, Laheru D
J Clin Oncol. 2009
PubMed ID: 19273710
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.
Van Cutsem E, Köhne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, D'Haens G, Pintér T, Lim R, Bodoky G, Roh JK, Folprecht G, Ruff P, Stroh C, Tejpar S, Schlichting M, Nippgen J, Rougier P
N Engl J Med. 2009
PubMed ID: 19339720
-
Results of a phase I trial of 12 patients with locally advanced pancreatic carcinoma combining gefitinib, paclitaxel, and 3-dimensional conformal radiation: report of toxicity and evaluation of circulating K-ras as a potential biomarker of response to the
Olsen CC, Schefter TE, Chen H, Kane M, Leong S, McCarter MD, Chen Y, Mack P, Eckhardt SG, Stiegmann G, Raben D
Am J Clin Oncol. 2009
PubMed ID: 19307945
-
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, Bavieri M, Murer B, Meschiari E, Tamberi S, Cadioli A, Luppi F, Migaldi M, Rossi G
Am J Clin Pathol. 2009
PubMed ID: 19289583
-
Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.
Shi G, Zhu L, Sun Y, Bettencourt R, Damsz B, Hruban RH, Konieczny SF
Gastroenterology. 2009
PubMed ID: 19249398
-
EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.
Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, Mun MY, Sakao Y, Okumura S, Nakagawa K, Soda M, Choi YL, Mano H, Ishikawa Y
Mod Pathol. 2009
PubMed ID: 19234440
-
Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.
Sarkozy A, Carta C, Moretti S, Zampino G, Digilio MC, Pantaleoni F, Scioletti AP, Esposito G, Cordeddu V, Lepri F, Petrangeli V, Dentici ML, Mancini GM, Selicorni A, Rossi C, Mazzanti L, Marino B, Ferrero GB, Silengo MC, Memo L, Stanzial F, Faravelli F, Stuppia L, Puxeddu E, Gelb BD, Dallapiccola B, Tartaglia M
Hum Mutat. 2009
PubMed ID: 19206169
-
PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1.
Xia S, Chen Z, Forman LW, Faller DV
Cell Signal. 2009
PubMed ID: 19146951
-
Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model.
Moghaddam SJ, Li H, Cho SN, Dishop MK, Wistuba II, Ji L, Kurie JM, Dickey BF, Demayo FJ
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18927348
-
Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer.
Quaye L, Song H, Ramus SJ, Gentry-Maharaj A, Høgdall E, DiCioccio RA, McGuire V, Wu AH, Van Den Berg DJ, Pike MC, Wozniak E, Doherty JA, Rossing MA, Ness RB, Moysich KB, Høgdall C, Blaakaer J, Ovarian Cancer Association Consortium, Easton DF, Ponder BA, Jacobs IJ, Menon U, Whittemore AS, Krüger-Kjaer S, Pearce CL, Pharoah PD, Gayther SA
Br J Cancer. 2009
PubMed ID: 19240718
-
PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.
Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS
J Clin Oncol. 2009
PubMed ID: 19237633
-
Oncogenic Kras initiates leukemia in hematopoietic stem cells.
Sabnis AJ, Cheung LS, Dail M, Kang HC, Santaguida M, Hermiston ML, Passegué E, Shannon K, Braun BS
PLoS Biol. 2009
PubMed ID: 19296721
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19246386
-
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Ho VM, Schaffer BE, Karnezis AN, Park KS, Sage J
Oncogene. 2009
PubMed ID: 19151761
-
Role of miR-143 targeting KRAS in colorectal tumorigenesis.
Chen X, Guo X, Zhang H, Xiang Y, Chen J, Yin Y, Cai X, Wang K, Wang G, Ba Y, Zhu L, Wang J, Yang R, Zhang Y, Ren Z, Zen K, Zhang J, Zhang CY
Oncogene. 2009
PubMed ID: 19137007
-
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Khasawneh J, Schulz MD, Walch A, Rozman J, Hrabe de Angelis M, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19208810
-
[Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer]
Estrada P, Rojas-Atencio A, Zabala W, Borjas L, Soca L, Urdaneta K, Alvarez-Nava F, Cañizales J, Rojas J, Soto M
Invest Clin. 2009
PubMed ID: 19418727
-
KRAS mutations and susceptibility to cetuximab and panitumumab in colorectal cancer.
Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG
Cancer J. 2009
PubMed ID: 19390304
-
EGFR and KRAS mutations in patients with adenocarcinoma of the lung.
Jang TW, Oak CH, Chang HK, Suo SJ, Jung MH
Korean J Intern Med. 2009
PubMed ID: 19270482
-
EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort.
Varella-Garcia M, Mitsudomi T, Yatabe Y, Kosaka T, Nakajima E, Xavier AC, Skokan M, Zeng C, Franklin WA, Bunn PA, Hirsch FR
J Thorac Oncol. 2009
PubMed ID: 19247083
-
Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.
Bibeau F, Lopez-Crapez E, Di Fiore F, Thezenas S, Ychou M, Blanchard F, Lamy A, Penault-Llorca F, Frébourg T, Michel P, Sabourin JC, Boissière-Michot F
J Clin Oncol. 2009
PubMed ID: 19164213
-
Microsatellite instability-low colorectal cancer acquires a KRAS mutation during the progression from Dukes' A to Dukes' B.
Asaka S, Arai Y, Nishimura Y, Yamaguchi K, Ishikubo T, Yatsuoka T, Tanaka Y, Akagi K
Carcinogenesis. 2009
PubMed ID: 19147861
-
KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient selection.
Jimeno A, Messersmith WA, Hirsch FR, Franklin WA, Eckhardt SG
J Clin Oncol. 2009
PubMed ID: 19124802
-
NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.
Huang CC, Chien WP, Wong RH, Cheng YW, Chen MC, Lee H
Environ Mol Mutagen. 2009
PubMed ID: 19107910
-
Overexpressed vs mutated Kras in murine fibroblasts: a molecular phenotyping study.
Horsch M, Recktenwald CV, Schädler S, Hrabé de Angelis M, Seliger B, Beckers J
Br J Cancer. 2009
PubMed ID: 19190631
-
K-ras mutations and cetuximab in colorectal cancer.
Marchetti A, Gasparini G
N Engl J Med. 2009
PubMed ID: 19228630
-
Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans.
Kumar K, Brim H, Giardiello F, Smoot DT, Nouraie M, Lee EL, Ashktorab H
Clin Cancer Res. 2009
PubMed ID: 19190129
-
MLL5 contributes to hematopoietic stem cell fitness and homeostasis.
Zhang Y, Wong J, Klinger M, Tran MT, Shannon KM, Killeen N
Blood. 2009
PubMed ID: 18818388
-
Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer.
Tol J, Koopman M, Cats A, Rodenburg CJ, Creemers GJ, Schrama JG, Erdkamp FL, Vos AH, van Groeningen CJ, Sinnige HA, Richel DJ, Voest EE, Dijkstra JR, Vink-Börger ME, Antonini NF, Mol L, van Krieken JH, Dalesio O, Punt CJ
N Engl J Med. 2009
PubMed ID: 19196673
-
Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation.
Zhang J, Wang J, Liu Y, Sidik H, Young KH, Lodish HF, Fleming MD
Blood. 2009
PubMed ID: 19066392
-
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer]
Cvetković G, Plavec G, Tomić I, Ilić V, Magić Z, Tatomirović Z, Novković D, Milić R, Karlicić V
Vojnosanit Pregl. 2009
PubMed ID: 19281127
-
KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
Shi C, Hong SM, Lim P, Kamiyama H, Khan M, Anders RA, Goggins M, Hruban RH, Eshleman JR
Mol Cancer Res. 2009
PubMed ID: 19208745
-
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
Leedham SJ, Graham TA, Oukrif D, McDonald SA, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR, Jankowski JA, Wright NA
Gastroenterology. 2009
PubMed ID: 19103203
-
Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9.
Wang XQ, Li H, Van Putten V, Winn RA, Heasley LE, Nemenoff RA
Mol Biol Cell. 2009
PubMed ID: 19037103
-
High detection rates of colorectal neoplasia by stool DNA testing with a novel digital melt curve assay.
Zou H, Taylor WR, Harrington JJ, Hussain FT, Cao X, Loprinzi CL, Levine TR, Rex DK, Ahnen D, Knigge KL, Lance P, Jiang X, Smith DI, Ahlquist DA
Gastroenterology. 2009
PubMed ID: 19026650
-
RAS and RAF mutations in banal melanocytic aggregates contiguous with primary cutaneous melanoma: clues to melanomagenesis.
Dadzie OE, Yang S, Emley A, Keady M, Bhawan J, Mahalingam M
Br J Dermatol. 2009
PubMed ID: 18945298
-
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice.
Yin X, Cong X, Yan M, Zhang DE
Lung Cancer. 2009
PubMed ID: 18571763
-
The importance of KRAS mutations and EGF61A>G polymorphism to the effect of cetuximab and irinotecan in metastatic colorectal cancer.
Garm Spindler KL, Pallisgaard N, Rasmussen AA, Lindebjerg J, Andersen RF, Crüger D, Jakobsen A
Ann Oncol. 2009
PubMed ID: 19179548
-
Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade.
Cesarini L, Alfieri P, Pantaleoni F, Vasta I, Cerutti M, Petrangeli V, Mariotti P, Leoni C, Ricci D, Vicari S, Selicorni A, Tartaglia M, Mercuri E, Zampino G
Am J Med Genet A. 2009
PubMed ID: 19133693
-
KRAS mutations in primary colorectal cancer tumors and related metastases: a potential role in prediction of lung metastasis.
Cejas P, López-Gómez M, Aguayo C, Madero R, de Castro Carpeño J, Belda-Iniesta C, Barriuso J, Moreno García V, Larrauri J, López R, Casado E, Gonzalez-Barón M, Feliu J
PLoS One. 2009
PubMed ID: 20020061
-
Mutations in the KRAS gene in ovarian tumors.
Dobrzycka B, Terlikowski SJ, Kowalczuk O, Niklińska W, Chyczewski L, Kulikowski M
Folia Histochem Cytobiol. 2009
PubMed ID: 19995707
-
Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.
Holmes MV, Shah T, Vickery C, Smeeth L, Hingorani AD, Casas JP
PLoS One. 2009
PubMed ID: 19956635
-
Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.
Mito JK, Riedel RF, Dodd L, Lahat G, Lazar AJ, Dodd RD, Stangenberg L, Eward WC, Hornicek FJ, Yoon SS, Brigman BE, Jacks T, Lev D, Mukherjee S, Kirsch DG
PLoS One. 2009
PubMed ID: 19956606
-
Targeted KRAS mutation assessment on patient tumor histologic material in real time diagnostics.
Kotoula V, Charalambous E, Biesmans B, Malousi A, Vrettou E, Fountzilas G, Karkavelas G
PLoS One. 2009
PubMed ID: 19888477
-
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells.
Soh J, Okumura N, Lockwood WW, Yamamoto H, Shigematsu H, Zhang W, Chari R, Shames DS, Tang X, MacAulay C, Varella-Garcia M, Vooder T, Wistuba II, Lam S, Brekken R, Toyooka S, Minna JD, Lam WL, Gazdar AF
PLoS One. 2009
PubMed ID: 19826477
-
The role of KRAS mutations in predicting the efficacy of cetuximab-plus-irinotecan therapy in irinotecan-refractory Korean metastatic colorectal cancer patients.
Sohn BS, Kim TW, Lee JL, Ryu MH, Chang HM, Kang YK, Park HS, Na YS, Jang SJ, Kim JC, Lee JS
Oncology. 2009
PubMed ID: 19738388
-
Presence of activating KRAS mutations correlates significantly with expression of tumour suppressor genes DCN and TPM1 in colorectal cancer.
Mlakar V, Berginc G, Volavsek M, Stor Z, Rems M, Glavac D
BMC Cancer. 2009
PubMed ID: 19678923
-
A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.
Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
BMC Cancer. 2009
PubMed ID: 19545448
-
Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas.
Nielsen M, de Miranda NF, van Puijenbroek M, Jordanova ES, Middeldorp A, van Wezel T, van Eijk R, Tops CM, Vasen HF, Hes FJ, Morreau H
BMC Cancer. 2009
PubMed ID: 19527492
-
Fast simultaneous detection of K-RAS mutations in colorectal cancer.
Chang YS, Yeh KT, Chang TJ, Chai C, Lu HC, Hsu NC, Chang JG
BMC Cancer. 2009
PubMed ID: 19515263
-
A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations.
Kramer D, Thunnissen FB, Gallegos-Ruiz MI, Smit EF, Postmus PE, Meijer CJ, Snijders PJ, Heideman DA
Cell Oncol. 2009
PubMed ID: 19478384
-
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Efeyan A, Murga M, Martinez-Pastor B, Ortega-Molina A, Soria R, Collado M, Fernandez-Capetillo O, Serrano M
PLoS One. 2009
PubMed ID: 19421407
-
Mutations of the KRAS oncogene in endometrial hyperplasia and carcinoma.
Dobrzycka B, Terlikowski SJ, Mazurek A, Kowalczuk O, Niklińska W, Chyczewski L, Kulikowski M
Folia Histochem Cytobiol. 2009
PubMed ID: 19419940
-
KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.
Auner V, Kriegshäuser G, Tong D, Horvat R, Reinthaller A, Mustea A, Zeillinger R
BMC Cancer. 2009
PubMed ID: 19358724
-
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
Granville CA, Memmott RM, Balogh A, Mariotti J, Kawabata S, Han W, Lopiccolo J, Foley J, Liewehr DJ, Steinberg SM, Fowler DH, Hollander MC, Dennis PA
PLoS One. 2009
PubMed ID: 19330036
-
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP
PLoS One. 2009
PubMed ID: 19319189
-
Genetic analysis of KRAS mutation status in metastatic colorectal cancer patients.
Zavodna K, Konecny M, Krivulcik T, Spanik S, Behulova R, Vizvaryova M, Weismanova E, Galbavy S, Kausitz J
Neoplasma. 2009
PubMed ID: 19309232
-
Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.
Greco C, Vitelli G, Vercillo G, Vona R, Giannarelli D, Sperduti I, Pisani F, Capoluongo E, Petti MC, Ameglio F
J Exp Clin Cancer Res. 2009
PubMed ID: 19284554
-
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.
Gandhi J, Zhang J, Xie Y, Soh J, Shigematsu H, Zhang W, Yamamoto H, Peyton M, Girard L, Lockwood WW, Lam WL, Varella-Garcia M, Minna JD, Gazdar AF
PLoS One. 2009
PubMed ID: 19238210
-
Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.
Liang S, Yang N, Pan Y, Deng S, Lin X, Yang X, Katsaros D, Roby KF, Hamilton TC, Connolly DC, Coukos G, Zhang L
PLoS One. 2009
PubMed ID: 19172191
-
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer.
Hurwitz HI, Yi J, Ince W, Novotny WF, Rosen O
Oncologist. 2009
PubMed ID: 19144677
-
Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men.
Giedraitis V, Kilander L, Degerman-Gunnarsson M, Sundelöf J, Axelsson T, Syvänen AC, Lannfelt L, Glaser A
Dement Geriatr Cogn Disord. 2009
PubMed ID: 19141999
-
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.
Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D
Genes Dev. 2009
PubMed ID: 19136624
-
Role of 3'-phosphoinositides in oncogenic KRAS-induced modulation of shape and motility of airway epithelial cells.
Okudela K, Yazawa T, Suzuki T, Sugimura H, Kitamura H
Pathol Int. 2009
PubMed ID: 19121089
-
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ
Cancer Res. 2009
PubMed ID: 19118015
-
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Pearson HB, Phesse TJ, Clarke AR
Cancer Res. 2009
PubMed ID: 19117991
-
Progression of pancreatic adenocarcinoma is significantly impeded with a combination of vaccine and COX-2 inhibition.
Mukherjee P, Basu GD, Tinder TL, Subramani DB, Bradley JM, Arefayene M, Skaar T, De Petris G
J Immunol. 2009
PubMed ID: 19109152
-
Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma.
Kosaka T, Yatabe Y, Onozato R, Kuwano H, Mitsudomi T
J Thorac Oncol. 2009
PubMed ID: 19096302
-
Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC).
Lim EH, Zhang SL, Li JL, Yap WS, Howe TC, Tan BP, Lee YS, Wong D, Khoo KL, Seto KY, Tan L, Agasthian T, Koong HN, Tam J, Tan C, Caleb M, Chang A, Ng A, Tan P
J Thorac Oncol. 2009
PubMed ID: 19096301
-
Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.
Zhao B, Benson EK, Qiao R, Wang X, Kim S, Manfredi JJ, Lee SW, Aaronson SA
EMBO Rep. 2009
PubMed ID: 19079133
-
The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies.
Bansal N, Yendluri V, Wenham RM
Cancer Control. 2009
PubMed ID: 19078924
-
The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.
Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM, Nicholson AG, Zhang Q, Kraja A, Spendlove I, Osborne J, Mardis E, Longmore GD
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19060205
-
KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer.
Nakayama N, Nakayama K, Yeasmin S, Ishibashi M, Katagiri A, Iida K, Fukumoto M, Miyazaki K
Br J Cancer. 2008
PubMed ID: 19018267
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer.
Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A
J Clin Oncol. 2008
PubMed ID: 19001320
-
Distinct thresholds govern Myc's biological output in vivo.
Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA, Brown-Swigart L, Johnson L, Evan GI
Cancer Cell. 2008
PubMed ID: 19061836
-
Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia.
De La O JP, Emerson LL, Goodman JL, Froebe SC, Illum BE, Curtis AB, Murtaugh LC
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19028876
-
KRAS mutation in metastatic colorectal cancer and its impact on the use of EGFR inhibitors.
Lenz HJ, Chu E, Grothey A
Clin Adv Hematol Oncol. 2008
PubMed ID: 19378369
-
Genetic and epigenetic alterations of familial pancreatic cancers.
Brune K, Hong SM, Li A, Yachida S, Abe T, Griffith M, Yang D, Omura N, Eshleman J, Canto M, Schulick R, Klein AP, Hruban RH, Iacobuzio-Donohue C, Goggins M
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064568
-
Epidermal growth factor receptor-related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: an analysis of patients from german centers in the TRUST study.
Schneider CP, Heigener D, Schott-von-Römer K, Gütz S, Laack E, Digel W, Guschall WR, Franke A, Bodenstein H, Schmidtgen C, Reck M
J Thorac Oncol. 2008
PubMed ID: 19057271
-
High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice.
Santini D, Loupakis F, Vincenzi B, Floriani I, Stasi I, Canestrari E, Rulli E, Maltese PE, Andreoni F, Masi G, Graziano F, Baldi GG, Salvatore L, Russo A, Perrone G, Tommasino MR, Magnani M, Falcone A, Tonini G, Ruzzo A
Oncologist. 2008
PubMed ID: 19056857
-
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Lurje G, Nagashima F, Zhang W, Yang D, Chang HM, Gordon MA, El-Khoueiry A, Husain H, Wilson PM, Ladner RD, Mauro DJ, Langer C, Rowinsky EK, Lenz HJ
Clin Cancer Res. 2008
PubMed ID: 19047118
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, García-Echeverría C, Weissleder R, Mahmood U, Cantley LC, Wong KK
Nat Med. 2008
PubMed ID: 19029981
-
Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis.
Boparai KS, Dekker E, Van Eeden S, Polak MM, Bartelsman JF, Mathus-Vliegen EM, Keller JJ, van Noesel CJ
Gastroenterology. 2008
PubMed ID: 19013464
-
An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia.
Agarwal A, Eide CA, Harlow A, Corbin AS, Mauro MJ, Druker BJ, Corless CL, Heinrich MC, Deininger MW
Leukemia. 2008
PubMed ID: 18509354
-
Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia.
Yoshida N, Yagasaki H, Xu Y, Matsuda K, Yoshimi A, Takahashi Y, Hama A, Nishio N, Muramatsu H, Watanabe N, Matsumoto K, Kato K, Ueyama J, Inada H, Goto H, Yabe M, Kudo K, Mimaya J, Kikuchi A, Manabe A, Koike K, Kojima S
Pediatr Res. 2008
PubMed ID: 19047918
-
Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer.
Cheung AF, Dupage MJ, Dong HK, Chen J, Jacks T
Cancer Res. 2008
PubMed ID: 19010921
-
Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours.
Bottillo I, Ahlquist T, Brekke H, Danielsen SA, van den Berg E, Mertens F, Lothe RA, Dallapiccola B
J Pathol. 2008
PubMed ID: 19142971
-
KRAS mutational testing in the selection of patients for EGFR-targeted therapies.
Garcia J, Riely GJ, Nafa K, Ladanyi M
Semin Diagn Pathol. 2008
PubMed ID: 19013894
-
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification.
Chen S, Auletta T, Dovirak O, Hutter C, Kuntz K, El-ftesi S, Kendall J, Han H, Von Hoff DD, Ashfaq R, Maitra A, Iacobuzio-Donahue CA, Hruban RH, Lucito R
Cancer Biol Ther. 2008
PubMed ID: 18836286
-
Rapid screening assay for KRAS mutations by the modified smart amplification process.
Tatsumi K, Mitani Y, Watanabe J, Takakura H, Hoshi K, Kawai Y, Kikuchi T, Kogo Y, Oguchi-Katayama A, Tomaru Y, Kanamori H, Baba M, Ishidao T, Usui K, Itoh M, Cizdziel PE, Lezhava A, Ueda M, Ichikawa Y, Endo I, Togo S, Shimada H, Hayashizaki Y
J Mol Diagn. 2008
PubMed ID: 18832461
-
Exclusive KRAS mutation in microsatellite-unstable human colorectal carcinomas with sequence alterations in the DNA mismatch repair gene, MLH1.
Zhao Y, Miyashita K, Ando T, Kakeji Y, Yamanaka T, Taguchi K, Ushijima T, Oda S, Maehara Y
Gene. 2008
PubMed ID: 18692554
-
Mutual exclusiveness between PIK3CA and KRAS mutations in endometrial carcinoma.
Kang S, Seo SS, Chang HJ, Yoo CW, Park SY, Dong SM
Int J Gynecol Cancer. 2008
PubMed ID: 18221484
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
Karapetis CS, Khambata-Ford S, Jonker DJ, O'Callaghan CJ, Tu D, Tebbutt NC, Simes RJ, Chalchal H, Shapiro JD, Robitaille S, Price TJ, Shepherd L, Au HJ, Langer C, Moore MJ, Zalcberg JR
N Engl J Med. 2008
PubMed ID: 18946061
-
Reversed mutation rates of KRAS and EGFR genes in adenocarcinoma of the lung in Taiwan and their implications.
Wu CC, Hsu HY, Liu HP, Chang JW, Chen YT, Hsieh WY, Hsieh JJ, Hsieh MS, Chen YR, Huang SF
Cancer. 2008
PubMed ID: 18932251
-
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
Chin LJ, Ratner E, Leng S, Zhai R, Nallur S, Babar I, Muller RU, Straka E, Su L, Burki EA, Crowell RE, Patel R, Kulkarni T, Homer R, Zelterman D, Kidd KK, Zhu Y, Christiani DC, Belinsky SA, Slack FJ, Weidhaas JB
Cancer Res. 2008
PubMed ID: 18922928
-
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.
Kindler T, Cornejo MG, Scholl C, Liu J, Leeman DS, Haydu JE, Fröhling S, Lee BH, Gilliland DG
Blood. 2008
PubMed ID: 18663146
-
Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth.
Eisenberg S, Giehl K, Henis YI, Ehrlich M
J Biol Chem. 2008
PubMed ID: 18693247
-
Modelling Myc inhibition as a cancer therapy.
Soucek L, Whitfield J, Martins CP, Finch AJ, Murphy DJ, Sodir NM, Karnezis AN, Swigart LB, Nasi S, Evan GI
Nature. 2008
PubMed ID: 18716624
-
A prospective study of dietary folate and vitamin B and colon cancer according to microsatellite instability and KRAS mutational status.
Schernhammer ES, Giovannuccci E, Fuchs CS, Ogino S
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18843035
-
CpG island methylator phenotype in colorectal cancers: comparison of the new and classic CpG island methylator phenotype marker panels.
Lee S, Cho NY, Yoo EJ, Kim JH, Kang GH
Arch Pathol Lab Med. 2008
PubMed ID: 18834226
-
Transformation by oncogenic Ras expands the early genomic response to transforming growth factor beta in intestinal epithelial cells.
Allen CE, Du J, Jiang B, Huang Q, Yakovich AJ, Barnard JA
Neoplasia. 2008
PubMed ID: 18813357
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
-
A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.
Ren XY, Liang ZY, Shi XH, Liu TH
Cancer Biol Ther. 2008
PubMed ID: 18769120
-
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer.
To MD, Wong CE, Karnezis AN, Del Rosario R, Di Lauro R, Balmain A
Nat Genet. 2008
PubMed ID: 18758463
-
Stabilization of beta-catenin induces pancreas tumor formation.
Heiser PW, Cano DA, Landsman L, Kim GE, Kench JG, Klimstra DS, Taketo MM, Biankin AV, Hebrok M
Gastroenterology. 2008
PubMed ID: 18725219
-
Loss of heterozygosity predicts poor survival after resection of pancreatic adenocarcinoma.
Franko J, Krasinskas AM, Nikiforova MN, Zarnescu NO, Lee KK, Hughes SJ, Bartlett DL, Zeh HJ, Moser AJ
J Gastrointest Surg. 2008
PubMed ID: 18677542
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
-
Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis.
Hegedus B, Yeh TH, Lee da Y, Emnett RJ, Li J, Gutmann DH
Hum Mol Genet. 2008
PubMed ID: 18614544
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW
Science. 2008
PubMed ID: 18772397
-
Cis-acting genomic elements of the Pas1 locus control Kras mutability in lung tumors.
Manenti G, Trincucci G, Pettinicchio A, Amendola E, Scarfò M, Dragani TA
Oncogene. 2008
PubMed ID: 18560355
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.
Linardou H, Dahabreh IJ, Kanaloupiti D, Siannis F, Bafaloukos D, Kosmidis P, Papadimitriou CA, Murray S
Lancet Oncol. 2008
PubMed ID: 18804418
-
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Kalikaki A, Koutsopoulos A, Trypaki M, Souglakos J, Stathopoulos E, Georgoulias V, Mavroudis D, Voutsina A
Br J Cancer. 2008
PubMed ID: 19238633
-
Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS.
Guha U, Chaerkady R, Marimuthu A, Patterson AS, Kashyap MK, Harsha HC, Sato M, Bader JS, Lash AE, Minna JD, Pandey A, Varmus HE
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18776048
-
Clinical usefulness of EGFR gene copy number as a predictive marker in colorectal cancer patients treated with cetuximab: a fluorescent in situ hybridization study.
Personeni N, Fieuws S, Piessevaux H, De Hertogh G, De Schutter J, Biesmans B, De Roock W, Capoen A, Debiec-Rychter M, Van Laethem JL, Peeters M, Humblet Y, Van Cutsem E, Tejpar S
Clin Cancer Res. 2008
PubMed ID: 18794099
-
The effects of common genetic variants in oncogenes on ovarian cancer survival.
Quaye L, Gayther SA, Ramus SJ, Di Cioccio RA, McGuire V, Hogdall E, Hogdall C, Blaakr J, Easton DF, Ponder BA, Jacobs I, Kjaer SK, Whittemore AS, Pearce CL, Pharoah PD, Song H
Clin Cancer Res. 2008
PubMed ID: 18794094
-
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.
Riely GJ, Kris MG, Rosenbaum D, Marks J, Li A, Chitale DA, Nafa K, Riedel ER, Hsu M, Pao W, Miller VA, Ladanyi M
Clin Cancer Res. 2008
PubMed ID: 18794081
-
Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer.
Artale S, Sartore-Bianchi A, Veronese SM, Gambi V, Sarnataro CS, Gambacorta M, Lauricella C, Siena S
J Clin Oncol. 2008
PubMed ID: 18757341
-
MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma.
Tinder TL, Subramani DB, Basu GD, Bradley JM, Schettini J, Million A, Skaar T, Mukherjee P
J Immunol. 2008
PubMed ID: 18713982
-
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS
J Clin Invest. 2008
PubMed ID: 18677410
-
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
-
Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl.
Slape C, Liu LY, Beachy S, Aplan PD
Blood. 2008
PubMed ID: 18566322
-
Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice.
Zerbe LK, Dwyer-Nield LD, Fritz JM, Redente EF, Shroyer RJ, Conklin E, Kane S, Tucker C, Eckhardt SG, Gustafson DL, Iwata KK, Malkinson AM
Cancer Chemother Pharmacol. 2008
PubMed ID: 18030469
-
Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis.
Joshi J, Fernandez-Marcos PJ, Galvez A, Amanchy R, Linares JF, Duran A, Pathrose P, Leitges M, Cañamero M, Collado M, Salas C, Serrano M, Moscat J, Diaz-Meco MT
EMBO J. 2008
PubMed ID: 18650932
-
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Dovey JS, Zacharek SJ, Kim CF, Lees JA
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18697930
-
Mutation of genes affecting the RAS pathway is common in childhood acute lymphoblastic leukemia.
Case M, Matheson E, Minto L, Hassan R, Harrison CJ, Bown N, Bailey S, Vormoor J, Hall AG, Irving JA
Cancer Res. 2008
PubMed ID: 18701506
-
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.
Wahlstrom AM, Cutts BA, Liu M, Lindskog A, Karlsson C, Sjogren AK, Andersson KM, Young SG, Bergo MO
Blood. 2008
PubMed ID: 18502828
-
Loss of integrin alpha1beta1 ameliorates Kras-induced lung cancer.
Macias-Perez I, Borza C, Chen X, Yan X, Ibanez R, Mernaugh G, Matrisian LM, Zent R, Pozzi A
Cancer Res. 2008
PubMed ID: 18676835
-
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Etienne-Grimaldi MC, Formento JL, Francoual M, François E, Formento P, Renée N, Laurent-Puig P, Chazal M, Benchimol D, Delpero JR, Letoublon C, Pezet D, Seitz JF, Milano G
Clin Cancer Res. 2008
PubMed ID: 18676755
-
PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients.
Perrone F, Lampis A, Orsenigo M, Di Bartolomeo M, Gevorgyan A, Losa M, Frattini M, Riva C, Andreola S, Bajetta E, Bertario L, Leo E, Pierotti MA, Pilotti S
Ann Oncol. 2008
PubMed ID: 18669866
-
Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells.
Ibiza S, Pérez-Rodríguez A, Ortega A, Martínez-Ruiz A, Barreiro O, García-Domínguez CA, Víctor VM, Esplugues JV, Rojas JM, Sánchez-Madrid F, Serrador JM
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18641128
-
Role of KRAS and EGFR As Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21.
Zhu CQ, da Cunha Santos G, Ding K, Sakurada A, Cutz JC, Liu N, Zhang T, Marrano P, Whitehead M, Squire JA, Kamel-Reid S, Seymour L, Shepherd FA, Tsao MS
J Clin Oncol. 2008
PubMed ID: 18626007
-
A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors.
Seidler B, Schmidt A, Mayr U, Nakhai H, Schmid RM, Schneider G, Saur D
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18621715
-
Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients.
Koivunen JP, Kim J, Lee J, Rogers AM, Park JO, Zhao X, Naoki K, Okamoto I, Nakagawa K, Yeap BY, Meyerson M, Wong KK, Richards WG, Sugarbaker DJ, Johnson BE, Jänne PA
Br J Cancer. 2008
PubMed ID: 18594528
-
Primary resistance to cetuximab therapy in EGFR FISH-positive colorectal cancer patients.
Cappuzzo F, Varella-Garcia M, Finocchiaro G, Skokan M, Gajapathy S, Carnaghi C, Rimassa L, Rossi E, Ligorio C, Di Tommaso L, Holmes AJ, Toschi L, Tallini G, Destro A, Roncalli M, Santoro A, Jänne PA
Br J Cancer. 2008
PubMed ID: 18577988
-
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
Lyronis ID, Baritaki S, Bizakis I, Krambovitis E, Spandidos DA
Pathol Oncol Res. 2008
PubMed ID: 18592405
-
RAS signaling in colorectal carcinomas through alteration of RAS, RAF, NF1, and/or RASSF1A.
Ahlquist T, Bottillo I, Danielsen SA, Meling GI, Rognum TO, Lind GE, Dallapiccola B, Lothe RA
Neoplasia. 2008
PubMed ID: 18592002
-
Human germline and somatic cells have similar TP53 and Kirsten-RAS gene single base mutation frequencies.
Cole DN, Carlson JA, Wilson VL
Environ Mol Mutagen. 2008
PubMed ID: 18418864
-
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Hu Y, McIntosh GH, Le Leu RK, Woodman R, Young GP
Cancer Res. 2008
PubMed ID: 18559541
-
A mouse to human search for plasma proteome changes associated with pancreatic tumor development.
Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM
PLoS Med. 2008
PubMed ID: 18547137
-
Spontaneous vulvar papillomas in a colony of mice used for pancreatic cancer research.
Gades NM, Ohash A, Mills LD, Rowley MA, Predmore KS, Marler RJ, Couch FJ
Comp Med. 2008
PubMed ID: 18589869
-
Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.
Park SW, Davison JM, Rhee J, Hruban RH, Maitra A, Leach SD
Gastroenterology. 2008
PubMed ID: 18549880
-
Estrogen promotes tumor progression in a genetically defined mouse model of lung adenocarcinoma.
Hammoud Z, Tan B, Badve S, Bigsby RM
Endocr Relat Cancer. 2008
PubMed ID: 18509000
-
Selective expression of KrasG12D in granulosa cells of the mouse ovary causes defects in follicle development and ovulation.
Fan HY, Shimada M, Liu Z, Cahill N, Noma N, Wu Y, Gossen J, Richards JS
Development. 2008
PubMed ID: 18506027
-
Structural polymorphism within a regulatory element of the human KRAS promoter: formation of G4-DNA recognized by nuclear proteins.
Cogoi S, Paramasivam M, Spolaore B, Xodo LE
Nucleic Acids Res. 2008
PubMed ID: 18490377
-
N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells.
Mor A, Keren G, Kloog Y, George J
Eur J Immunol. 2008
PubMed ID: 18461565
-
Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer.
Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, Boland CR, Goel A
Gastroenterology. 2008
PubMed ID: 18435933
-
[Molecular pathologic KRAS mutation analysis. A prerequisite of effective antibody treatment for metastasized colorectal cancer]
Dietel M, Tannapfel A, Baretton G, Kreipe H, Kloor M, Gabbert H, Kirchner T
Chirurg. 2008
PubMed ID: 18431556
-
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP, Murray NR
Int J Cancer. 2008
PubMed ID: 18271008
-
Distinct functions of H-Ras and K-Ras in proliferation and survival of primary hepatocytes due to selective activation of ERK and PI3K.
Rosseland CM, Wierød L, Flinder LI, Oksvold MP, Skarpen E, Huitfeldt HS
J Cell Physiol. 2008
PubMed ID: 18163378
-
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Turbiner J, Moreno-Bueno G, Dahiya S, Sánchez-Estevez C, Hardisson D, Prat J, Oliva E, Palacios J
Mod Pathol. 2008
PubMed ID: 18500270
-
Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion.
Quinlan MP, Settleman J
Cell Cycle. 2008
PubMed ID: 18418066
-
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.
Barault L, Veyrie N, Jooste V, Lecorre D, Chapusot C, Ferraz JM, Lièvre A, Cortet M, Bouvier AM, Rat P, Roignot P, Faivre J, Laurent-Puig P, Piard F
Int J Cancer. 2008
PubMed ID: 18224685
-
Partial functional overlap of the three ras genes in mouse embryonic development.
Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H, Kondo H, Katsuki M
Oncogene. 2008
PubMed ID: 18059342
-
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Freeman DJ, Juan T, Reiner M, Hecht JR, Meropol NJ, Berlin J, Mitchell E, Sarosi I, Radinsky R, Amado RG
Clin Colorectal Cancer. 2008
PubMed ID: 18621636
-
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T
Nat Genet. 2008
PubMed ID: 18372904
-
PIK3CA, HRAS and KRAS gene mutations in human penile cancer.
Andersson P, Kolaric A, Windahl T, Kirrander P, Söderkvist P, Karlsson MG
J Urol. 2008
PubMed ID: 18355852
-
PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas.
Schönleben F, Qiu W, Remotti HE, Hohenberger W, Su GH
Langenbecks Arch Surg. 2008
PubMed ID: 18343945
-
Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-ras(LA1) mice.
Jin H, Xu CX, Kim HW, Chung YS, Shin JY, Chang SH, Park SJ, Lee ES, Hwang SK, Kwon JT, Minai-Tehrani A, Woo M, Noh MS, Youn HJ, Kim DY, Yoon BI, Lee KH, Kim TH, Cho CS, Cho MH
Cancer Gene Ther. 2008
PubMed ID: 18292798
-
Identification of essential interacting elements in K-Ras/calmodulin binding and its role in K-Ras localization.
Lopez-Alcalá C, Alvarez-Moya B, Villalonga P, Calvo M, Bachs O, Agell N
J Biol Chem. 2008
PubMed ID: 18182391
-
EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients.
Wang Z, Wu YL, Zhang GC, Zhou Q, Xu CR, Guo AL
Onkologie. 2008
PubMed ID: 18418018
-
Oncogene cooperation in tumor maintenance and tumor recurrence in mouse mammary tumors induced by Myc and mutant Kras.
Podsypanina K, Politi K, Beverly LJ, Varmus HE
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18356293
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.
Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD
J Clin Oncol. 2008
PubMed ID: 18316791
-
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK
Carcinogenesis. 2008
PubMed ID: 18283039
-
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion.
Quinlan MP, Quatela SE, Philips MR, Settleman J
Mol Cell Biol. 2008
PubMed ID: 18268007
-
Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.
Patek CE, Arends MJ, Wallace WA, Luo F, Hagan S, Brownstein DG, Rose L, Devenney PS, Walker M, Plowman SJ, Berry RL, Kolch W, Sansom OJ, Harrison DJ, Hooper ML
Exp Cell Res. 2008
PubMed ID: 18062963
-
Shining the spotlight on shed KRAS in pancreatic cancer.
Sempere LF, Korc M
Cancer Biol Ther. 2008
PubMed ID: 18614859
-
Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients.
Akkiprik M, Celikel CA, Düşünceli F, Sönmez O, Güllüoğlu BM, Sav A, Ozer A
Turk J Gastroenterol. 2008
PubMed ID: 18386236
-
Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.
Hegedus B, Banerjee D, Yeh TH, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH
Cancer Res. 2008
PubMed ID: 18316617
-
Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection.
Shi C, Fukushima N, Abe T, Bian Y, Hua L, Wendelburg BJ, Yeo CJ, Hruban RH, Goggins MG, Eshleman JR
Cancer Biol Ther. 2008
PubMed ID: 18075308
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab.
De Roock W, Piessevaux H, De Schutter J, Janssens M, De Hertogh G, Personeni N, Biesmans B, Van Laethem JL, Peeters M, Humblet Y, Van Cutsem E, Tejpar S
Ann Oncol. 2008
PubMed ID: 17998284
-
Association of KRAS Polymorphisms with Risk for Lung Adenocarcinoma Accompanied by Atypical Adenomatous Hyperplasias.
Kohno T, Kunitoh H, Suzuki K, Yamamoto S, Kuchiba A, Matsuno Y, Yanagitani N, Yokota J
Carcinogenesis. 2008
PubMed ID: 18299280
-
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, Wistuba II, Kurie JM
Cancer Res. 2008
PubMed ID: 18281487
-
Palmitoylation and localisation of RAS isoforms are modulated by the hypervariable linker domain.
Laude AJ, Prior IA
J Cell Sci. 2008
PubMed ID: 18211960
-
Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma.
Marks JL, Broderick S, Zhou Q, Chitale D, Li AR, Zakowski MF, Kris MG, Rusch VW, Azzoli CG, Seshan VE, Ladanyi M, Pao W
J Thorac Oncol. 2008
PubMed ID: 18303429
-
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Sartori G, Cavazza A, Bertolini F, Longo L, Marchioni A, Costantini M, Barbieri F, Migaldi M, Rossi G
Am J Clin Pathol. 2008
PubMed ID: 18208799
-
Clinicopathological features of CpG island methylator phenotype-positive colorectal cancer and its adverse prognosis in relation to KRAS/BRAF mutation.
Lee S, Cho NY, Choi M, Yoo EJ, Kim JH, Kang GH
Pathol Int. 2008
PubMed ID: 18199160
-
Cooperating mutations of receptor tyrosine kinases and Ras genes in childhood core-binding factor acute myeloid leukemia and a comparative analysis on paired diagnosis and relapse samples.
Shih LY, Liang DC, Huang CF, Chang YT, Lai CL, Lin TH, Yang CP, Hung IJ, Liu HC, Jaing TH, Wang LY, Yeh TC
Leukemia. 2008
PubMed ID: 17960171
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab.
Lièvre A, Bachet JB, Boige V, Cayre A, Le Corre D, Buc E, Ychou M, Bouché O, Landi B, Louvet C, André T, Bibeau F, Diebold MD, Rougier P, Ducreux M, Tomasic G, Emile JF, Penault-Llorca F, Laurent-Puig P
J Clin Oncol. 2008
PubMed ID: 18202412
-
Mutations of RAS gene family in specimens of bladder cancer.
Karimianpour N, Mousavi-Shafaei P, Ziaee AA, Akbari MT, Pourmand G, Abedi A, Ahmadi A, Afshin Alavi H
Urol J. 2008
PubMed ID: 19101897
-
Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context.
Monticone M, Biollo E, Maffei M, Donadini A, Romeo F, Storlazzi CT, Giaretti W, Castagnola P
Mol Cancer. 2008
PubMed ID: 19087308
-
PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
Ko JM, Kim JM, Kim GH, Yoo HW
J Hum Genet. 2008
PubMed ID: 19020799
-
Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample.
Nosho K, Irahara N, Shima K, Kure S, Kirkner GJ, Schernhammer ES, Hazra A, Hunter DJ, Quackenbush J, Spiegelman D, Giovannucci EL, Fuchs CS, Ogino S
PLoS ONE. 2008
PubMed ID: 19002263
-
K-RAS and P53 mutations in association with COX-2 and hTERT expression and clinico-pathological status of NSCLC patients.
Strazisar M, Rott T, Glavac D
Dis Markers. 2008
PubMed ID: 18957720
-
Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations.
Felderbauer P, Stricker I, Schnekenburger J, Bulut K, Chromik AM, Belyaev O, Muller CA, Uhl W, Tannapfel A, Schmidt WE
Digestion. 2008
PubMed ID: 18946221
-
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
Agaev BA, Muslimov GF, Iagublu VSh, Babaeva NR
Khirurgiia (Mosk). 2008
PubMed ID: 18833187
-
BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
Velho S, Moutinho C, Cirnes L, Albuquerque C, Hamelin R, Schmitt F, Carneiro F, Oliveira C, Seruca R
BMC Cancer. 2008
PubMed ID: 18782444
-
KRAS mutation profile in colorectal carcinoma and novel mutation--internal tandem duplication in KRAS.
Wójcik P, Kulig J, Okoń K, Zazula M, Moździoch I, Niepsuj A, Stachura J
Pol J Pathol. 2008
PubMed ID: 18669174
-
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
Patek CE, Arends MJ, Rose L, Luo F, Walker M, Devenney PS, Berry RL, Lawrence NJ, Ridgway RA, Sansom OJ, Hooper ML
BMC Gastroenterol. 2008
PubMed ID: 18554389
-
A polymorphism of EGFR extracellular domain is associated with progression free-survival in metastatic colorectal cancer patients receiving cetuximab-based treatment.
Gonçalves A, Esteyries S, Taylor-Smedra B, Lagarde A, Ayadi M, Monges G, Bertucci F, Esterni B, Delpero JR, Turrini O, Lelong B, Viens P, Borg JP, Birnbaum D, Olschwang S, Viret F
BMC Cancer. 2008
PubMed ID: 18544172
-
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G, Demayo FJ, Kim CF, Kurie JM
PLoS ONE. 2008
PubMed ID: 18493606
-
[K-ras mutation as a prognostic factor in colorectal carcinoma]
Sácha M, Havlícek K, Sákra L, Rajman M, Beránek M
Rozhl Chir. 2008
PubMed ID: 18432074
-
Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms.
Kobayashi N, Inamori M, Fujita K, Fujisawa T, Fujisawa N, Takahashi H, Yoneda M, Abe Y, Kawamura H, Shimamura T, Kirikoshi H, Kubota K, Sakaguchi T, Saito S, Saubermann LJ, Nakajima A
J Hepatobiliary Pancreat Surg. 2008
PubMed ID: 18392710
-
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
Goutas N, Vlachodimitropoulos D, Bouka M, Lazaris AC, Nasioulas G, Gazouli M
Anticancer Res. 2008
PubMed ID: 18383861
-
siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma.
Yamanaka S, Gu Z, Sato M, Fujisaki R, Inomata K, Sakurada A, Inoue A, Nukiwa T, Kondo T, Horii A
Pathobiology. 2008
PubMed ID: 18334834
-
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
Bornholdt J, Hansen J, Steiniche T, Dictor M, Antonsen A, Wolff H, Schlünssen V, Holmila R, Luce D, Vogel U, Husgafvel-Pursiainen K, Wallin H
BMC Cancer. 2008
PubMed ID: 18289366
-
Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G > T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.
van Puijenbroek M, Nielsen M, Tops CM, Halfwerk H, Vasen HF, Weiss MM, van Wezel T, Hes FJ, Morreau H
Clin Cancer Res. 2008
PubMed ID: 18172263
-
Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia.
Paulsson K, Horvat A, Strömbeck B, Nilsson F, Heldrup J, Behrendtz M, Forestier E, Andersson A, Fioretos T, Johansson B
Genes Chromosomes Cancer. 2008
PubMed ID: 17910045
-
Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung.
Kim YT, Kim TY, Lee DS, Park SJ, Park JY, Seo SJ, Choi HS, Kang HJ, Hahn S, Kang CH, Sung SW, Kim JH
Lung Cancer. 2008
PubMed ID: 17904685
-
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
Jeon CH, Lee HI, Shin IH, Park JW
Int J Colorectal Dis. 2008
PubMed ID: 17704924
-
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
Wang JY, Hsieh JS, Lu CY, Yu FJ, Wu JY, Chen FM, Huang CJ, Lin SR
Hepatogastroenterology. 2007
PubMed ID: 18265644
-
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Guo H, Cajaiba MM, Borys D, Gutierrez MC, Yee H, Drut RM, Drut R, Askin F, Reyes-Múgica M, Greco MA
Hum Pathol. 2007
PubMed ID: 17714760
-
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
Nava C, Hanna N, Michot C, Pereira S, Pouvreau N, Niihori T, Aoki Y, Matsubara Y, Arveiler B, Lacombe D, Pasmant E, Parfait B, Baumann C, Héron D, Sigaudy S, Toutain A, Rio M, Goldenberg A, Leheup B, Verloes A, Cavé H
J Med Genet. 2007
PubMed ID: 17704260
-
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Pandey J, Umphress SM, Kang Y, Angdisen J, Naumova A, Mercer KL, Jacks T, Jakowlew SB
Carcinogenesis. 2007
PubMed ID: 17690114
-
RbAp48 regulates cytoskeletal organization and morphology by increasing K-Ras activity and signaling through mitogen-activated protein kinase.
Scuto A, Zhang H, Zhao H, Rivera M, Yeatman TJ, Jove R, Torres-Roca JF
Cancer Res. 2007
PubMed ID: 17974974
-
Biochemical and functional characterization of germ line KRAS mutations.
Schubbert S, Bollag G, Lyubynska N, Nguyen H, Kratz CP, Zenker M, Niemeyer CM, Molven A, Shannon K
Mol Cell Biol. 2007
PubMed ID: 17875937
-
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
Prall F, Ostwald C
Hum Pathol. 2007
PubMed ID: 17707462
-
RAS/ERK modulates TGFbeta-regulated PTEN expression in human pancreatic adenocarcinoma cells.
Chow JY, Quach KT, Cabrera BL, Cabral JA, Beck SE, Carethers JM
Carcinogenesis. 2007
PubMed ID: 17638924
-
Single base instability is promoted in vulvar lichen sclerosus.
Tapp RA, Feng J, Jones JW, Carlson JA, Wilson VL
J Invest Dermatol. 2007
PubMed ID: 17554370
-
A genetic mouse model for metastatic lung cancer with gender differences in survival.
Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G
Oncogene. 2007
PubMed ID: 17486075
-
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.
Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH
Cell Stem Cell. 2007
PubMed ID: 18371380
-
Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.
Cyniak-Magierska A, Brzeziańska E, Januszkiewicz-Caulier J, Jarzab B, Lewiński A
Exp Clin Endocrinol Diabetes. 2007
PubMed ID: 17943694
-
Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer.
Mallakin A, Sugiyama T, Taneja P, Matise LA, Frazier DP, Choudhary M, Hawkins GA, D'Agostino RB, Willingham MC, Inoue K
Cancer Cell. 2007
PubMed ID: 17936562
-
Dynamics of the immune reaction to pancreatic cancer from inception to invasion.
Clark CE, Hingorani SR, Mick R, Combs C, Tuveson DA, Vonderheide RH
Cancer Res. 2007
PubMed ID: 17909062
-
P21WAF1/CIP1 expression in colorectal carcinomas is related to Kras mutations and prognosis.
Mitomi H, Ohkura Y, Fukui N, Kanazawa H, Kishimoto I, Nakamura T, Yokoyama K, Sada M, Kobayashi K, Tanabe S, Saigenji K
Eur J Gastroenterol Hepatol. 2007
PubMed ID: 17873613
-
Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes.
Weijenberg MP, Lüchtenborg M, de Goeij AF, Brink M, van Muijen GN, de Bruïne AP, Goldbohm RA, van den Brandt PA
Cancer Causes Control. 2007
PubMed ID: 17636402
-
Wild-type NRas and KRas perform distinct functions during transformation.
Fotiadou PP, Takahashi C, Rajabi HN, Ewen ME
Mol Cell Biol. 2007
PubMed ID: 17636015
-
Point mutation of K-ras gene in cisplatin-induced lung tumours in A/J mice.
Hisamoto A, Kondo E, Kiura K, Okada T, Hosokawa S, Mimoto J, Takigawa N, Tabata M, Tanimoto M
Lung Cancer. 2007
PubMed ID: 17604873
-
Changes in gene-expression profiles of colon carcinoma cells induced by wild type K-ras2.
Li H, Cao HF, Li Y, Zhu ML, Wan J
World J Gastroenterol. 2007
PubMed ID: 17729418
-
RASSF6 is a novel member of the RASSF family of tumor suppressors.
Allen NP, Donninger H, Vos MD, Eckfeld K, Hesson L, Gordon L, Birrer MJ, Latif F, Clark GJ
Oncogene. 2007
PubMed ID: 17404571
-
Origin and prognostic value of circulating KRAS mutations in lung cancer patients.
Gautschi O, Huegli B, Ziegler A, Gugger M, Heighway J, Ratschiller D, Mack PC, Gumerlock PH, Kung HJ, Stahel RA, Gandara DR, Betticher DC
Cancer Lett. 2007
PubMed ID: 17449174
-
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Vatan O, Bilaloglu R, Tunca B, Cecener G, Gebitekin C, Egeli U, Yakut T, Urer N
Tumori. 2007
PubMed ID: 18038880
-
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
-
Ras pathway activation in malignant mesothelioma.
Patel MR, Jacobson BA, De A, Frizelle SP, Janne P, Thumma SC, Whitson BA, Farassati F, Kratzke RA
J Thorac Oncol. 2007
PubMed ID: 17805054
-
Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.
Kojima K, Vickers SM, Adsay NV, Jhala NC, Kim HG, Schoeb TR, Grizzle WE, Klug CA
Cancer Res. 2007
PubMed ID: 17804724
-
Requirement for Rac1 in a K-ras induced lung cancer in the mouse.
Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T
Cancer Res. 2007
PubMed ID: 17804720
-
Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.
Siveke JT, Einwächter H, Sipos B, Lubeseder-Martellato C, Klöppel G, Schmid RM
Cancer Cell. 2007
PubMed ID: 17785207
-
Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler.
Sasaki H, Okuda K, Kawano O, Endo K, Yukiue H, Yokoyama T, Yano M, Fujii Y
Oncol Rep. 2007
PubMed ID: 17671710
-
LKB1 modulates lung cancer differentiation and metastasis.
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Jänne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK
Nature. 2007
PubMed ID: 17676035
-
Patterns of PIK3CA alterations in familial colorectal and endometrial carcinoma.
Ollikainen M, Gylling A, Puputti M, Nupponen NN, Abdel-Rahman WM, Butzow R, Peltomäki P
Int J Cancer. 2007
PubMed ID: 17471559
-
Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma.
Mukai S, Hiyama T, Tanaka S, Yoshihara M, Arihiro K, Chayama K
World J Gastroenterol. 2007
PubMed ID: 17663506
-
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T
Nat Med. 2007
PubMed ID: 17676052
-
Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer.
Crous-Bou M, Porta M, López T, Jariod M, Malats N, Alguacil J, Morales E, Fernandez E, Corominas JM, Carrato A, Guarner L, Real FX, PANKRAS II Study Group
Pancreas. 2007
PubMed ID: 17632319
-
Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
Soliman AS, Lo AC, Banerjee M, El-Ghawalby N, Khaled HM, Bayoumi S, Seifeldin IA, Abdel-Aziz A, Abbruzzese JL, Greenson JK, Hamilton SR
Carcinogenesis. 2007
PubMed ID: 17575320
-
Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.
Liu XS, Li XH, Wang Y, Shu RZ, Wang L, Lu SY, Kong H, Jin YE, Zhang LJ, Fei J, Chen SJ, Chen Z, Gu MM, Lu ZY, Wang ZG
Blood. 2007
PubMed ID: 17431131
-
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Salek C, Benesova L, Zavoral M, Nosek V, Kasperova L, Ryska M, Strnad R, Traboulsi E, Minarik M
World J Gastroenterol. 2007
PubMed ID: 17659731
-
Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.
Derouet M, Wu X, May L, Hoon Yoo B, Sasazuki T, Shirasawa S, Rak J, Rosen KV
Neoplasia. 2007
PubMed ID: 17710156
-
No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations.
Kimura K, Nagasaka T, Hoshizima N, Sasamoto H, Notohara K, Takeda M, Kominami K, Iishii T, Tanaka N, Matsubara N
J Int Med Res. 2007
PubMed ID: 17697521
-
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR
J Clin Invest. 2007
PubMed ID: 17607363
-
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.
Søvik O, Schubbert S, Houge G, Steine SJ, Norgård G, Engelsen B, Njølstad PR, Shannon K, Molven A
J Med Genet. 2007
PubMed ID: 17601930
-
The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis.
Dehari R, Kurman RJ, Logani S, Shih IeM
Am J Surg Pathol. 2007
PubMed ID: 17592266
-
Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.
Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF
Am J Pathol. 2007
PubMed ID: 17591971
-
Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features.
Finberg KE, Sequist LV, Joshi VA, Muzikansky A, Miller JM, Han M, Beheshti J, Chirieac LR, Mark EJ, Iafrate AJ
J Mol Diagn. 2007
PubMed ID: 17591931
-
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Sakuma Y, Matsukuma S, Yoshihara M, Nakamura Y, Noda K, Nakayama H, Kameda Y, Tsuchiya E, Miyagi Y
Am J Clin Pathol. 2007
PubMed ID: 17580276
-
Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer.
Morales E, Porta M, Vioque J, López T, Mendez MA, Pumarega J, Malats N, Crous-Bou M, Ngo J, Rifà J, Carrato A, Guarner L, Corominas JM, Real FX, PANKRAS II Study Group
J Epidemiol Community Health. 2007
PubMed ID: 17568059
-
Congenital ulcerating hemangioma in a baby with KRAS mutation and cardio-facio-cutaneous syndrome.
Tang B, Reardon W, Black GC, Kerr BA
Clin Dysmorphol. 2007
PubMed ID: 17551339
-
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Chong IW, Chang MY, Sheu CC, Wang CY, Hwang JJ, Huang MS, Lin SR
Oncol Rep. 2007
PubMed ID: 17549340
-
Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas.
Sakamoto H, Shimizu J, Horio Y, Ueda R, Takahashi T, Mitsudomi T, Yatabe Y
J Pathol. 2007
PubMed ID: 17534846
-
K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
Réjiba S, Wack S, Aprahamian M, Hajri A
Cancer Sci. 2007
PubMed ID: 17489984
-
Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma.
Shibata T, Hanada S, Kokubu A, Matsuno Y, Asamura H, Ohta T, Sakamoto M, Hirohashi S
Cancer Sci. 2007
PubMed ID: 17459062
-
Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history.
Mounawar M, Mukeria A, Le Calvez F, Hung RJ, Renard H, Cortot A, Bollart C, Zaridze D, Brennan P, Boffetta P, Brambilla E, Hainaut P
Cancer Res. 2007
PubMed ID: 17575133
-
Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations.
Matsuda K, Shimada A, Yoshida N, Ogawa A, Watanabe A, Yajima S, Iizuka S, Koike K, Yanai F, Kawasaki K, Yanagimachi M, Kikuchi A, Ohtsuka Y, Hidaka E, Yamauchi K, Tanaka M, Yanagisawa R, Nakazawa Y, Shiohara M, Manabe A, Kojima S, Koike K
Blood. 2007
PubMed ID: 17332249
-
Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways.
Zhang J, Liu Y, Beard C, Tuveson DA, Jaenisch R, Jacks TE, Lodish HF
Blood. 2007
PubMed ID: 17317860
-
Mice thrive without Cdk4 and Cdk2.
Barrière C, Santamaría D, Cerqueira A, Galán J, Martín A, Ortega S, Malumbres M, Dubus P, Barbacid M
Mol Oncol. 2007
PubMed ID: 19383288
-
Clinical features reflect exon sites of EGFR mutations in patients with resected non-small-cell lung cancer.
Na II, Rho JK, Choi YJ, Kim CH, Koh JS, Ryoo BY, Yang SH, Lee JC
J Korean Med Sci. 2007
PubMed ID: 17596643
-
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J
Cell. 2007
PubMed ID: 17540175
-
A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation.
Preto A, Moutinho C, Velho S, Oliveira C, Rebocho AP, Figueiredo J, Soares P, Lopes JM, Seruca R
Virchows Arch. 2007
PubMed ID: 17487504
-
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR
Nat Genet. 2007
PubMed ID: 17468755
-
Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma.
Kang S, Kim HS, Seo SS, Park SY, Sidransky D, Dong SM
Gynecol Oncol. 2007
PubMed ID: 17360030
-
KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer.
Massarelli E, Varella-Garcia M, Tang X, Xavier AC, Ozburn NC, Liu DD, Bekele BN, Herbst RS, Wistuba II
Clin Cancer Res. 2007
PubMed ID: 17504988
-
Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex.
Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ
Oncogene. 2007
PubMed ID: 17130841
-
GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
Sjogren AK, Andersson KM, Liu M, Cutts BA, Karlsson C, Wahlstrom AM, Dalin M, Weinbaum C, Casey PJ, Tarkowski A, Swolin B, Young SG, Bergo MO
J Clin Invest. 2007
PubMed ID: 17476360
-
Impaired microRNA processing enhances cellular transformation and tumorigenesis.
Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T
Nat Genet. 2007
PubMed ID: 17401365
-
Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging.
Su W, Xing R, Guha A, Gutmann DH, Sherman LS
Glia. 2007
PubMed ID: 17348023
-
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Kaul A, Overmeyer JH, Maltese WA
Cell Signal. 2007
PubMed ID: 17210246
-
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells.
Van Meter ME, Díaz-Flores E, Archard JA, Passegué E, Irish JM, Kotecha N, Nolan GP, Shannon K, Braun BS
Blood. 2007
PubMed ID: 17192389
-
Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.
Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ
Cancer Res. 2007
PubMed ID: 17440063
-
Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.
Narumi Y, Aoki Y, Niihori T, Neri G, Cavé H, Verloes A, Nava C, Kavamura MI, Okamoto N, Kurosawa K, Hennekam RC, Wilson LC, Gillessen-Kaesbach G, Wieczorek D, Lapunzina P, Ohashi H, Makita Y, Kondo I, Tsuchiya S, Ito E, Sameshima K, Kato K, Kure S, Matsubara Y
Am J Med Genet A. 2007
PubMed ID: 17366577
-
Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma.
Lee J, Jang KT, Ki CS, Lim T, Park YS, Lim HY, Choi DW, Kang WK, Park K, Park JO
Cancer. 2007
PubMed ID: 17354229
-
Histopathological and genetic differences between polypoid and non-polypoid submucosal colorectal carcinoma.
Hirata I, Wang FY, Murano M, Inoue T, Toshina K, Nishikawa T, Maemura K
World J Gastroenterol. 2007
PubMed ID: 17465446
-
Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.
Janzarik WG, Kratz CP, Loges NT, Olbrich H, Klein C, Schäfer T, Scheurlen W, Roggendorf W, Weiller C, Niemeyer C, Korinthenberg R, Pfister S, Omran H
Neuropediatrics. 2007
PubMed ID: 17712732
-
K-ras and Dpc4 mutations in chronic pancreatitis: case series.
Popović Hadzija M, Korolija M, Jakić Razumović J, Pavković P, Hadzija M, Kapitanović S
Croat Med J. 2007
PubMed ID: 17436386
-
TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer.
Ogino S, Kawasaki T, Ogawa A, Kirkner GJ, Loda M, Fuchs CS
Hum Pathol. 2007
PubMed ID: 17270239
-
Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.
Shaw AT, Meissner A, Dowdle JA, Crowley D, Magendantz M, Ouyang C, Parisi T, Rajagopal J, Blank LJ, Bronson RT, Stone JR, Tuveson DA, Jaenisch R, Jacks T
Genes Dev. 2007
PubMed ID: 17369402
-
Quantification of oxidative posttranslational modifications of cysteine thiols of p21ras associated with redox modulation of activity using isotope-coded affinity tags and mass spectrometry.
Sethuraman M, Clavreul N, Huang H, McComb ME, Costello CE, Cohen RA
Free Radic Biol Med. 2007
PubMed ID: 17320764
-
The impact of epidermal growth factor receptor gene status on gefitinib-treated Japanese patients with non-small-cell lung cancer.
Ichihara S, Toyooka S, Fujiwara Y, Hotta K, Shigematsu H, Tokumo M, Soh J, Asano H, Ichimura K, Aoe K, Aoe M, Kiura K, Shimizu K, Date H, Shimizu N
Int J Cancer. 2007
PubMed ID: 17192902
-
The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia.
Carrière C, Seeley ES, Goetze T, Longnecker DS, Korc M
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360542
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Guerra C, Schuhmacher AJ, Cañamero M, Grippo PJ, Verdaguer L, Pérez-Gallego L, Dubus P, Sandgren EP, Barbacid M
Cancer Cell. 2007
PubMed ID: 17349585
-
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas.
Izeradjene K, Combs C, Best M, Gopinathan A, Wagner A, Grady WM, Deng CX, Hruban RH, Adsay NV, Tuveson DA, Hingorani SR
Cancer Cell. 2007
PubMed ID: 17349581
-
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Campbell PM, Groehler AL, Lee KM, Ouellette MM, Khazak V, Der CJ
Cancer Res. 2007
PubMed ID: 17332339
-
Distal phalangeal creases--a distinctive dysmorphic feature in disorders of the RAS signalling pathway?
Ørstavik KH, Tangeraas T, Molven A, Prescott TE
Eur J Med Genet. 2007
PubMed ID: 17324647
-
EGFR, ERBB2, and KRAS mutations in Korean non-small cell lung cancer patients.
Bae NC, Chae MH, Lee MH, Kim KM, Lee EB, Kim CH, Park TI, Han SB, Jheon S, Jung TH, Park JY
Cancer Genet Cytogenet. 2007
PubMed ID: 17321325
-
RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
Pijnenborg JM, Dam-de Veen GC, Kisters N, Delvoux B, van Engeland M, Herman JG, Groothuis PG
Ann Oncol. 2007
PubMed ID: 17170014
-
Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium.
Keller JW, Franklin JL, Graves-Deal R, Friedman DB, Whitwell CW, Coffey RJ
J Cell Physiol. 2007
PubMed ID: 17133351
-
K-ras is critical for modulating multiple c-kit-mediated cellular functions in wild-type and Nf1+/- mast cells.
Khalaf WF, Yang FC, Chen S, White H, Bessler W, Ingram DA, Clapp DW
J Immunol. 2007
PubMed ID: 17277161
-
Growth inhibitory effect of wild-type Kras2 gene on a colonic adenocarcinoma cell line.
Li H, Cao HF, Wan J, Li Y, Zhu ML, Zhao P
World J Gastroenterol. 2007
PubMed ID: 17352027
-
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
Liu F, Jiang B, Gong SJ, Yao BD, Zhang WY, Zhu GS, Zhu ZZ, Gong YF, Wang ML, Hu XH
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
PubMed ID: 17285540
-
Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.
Schmitz KJ, Wohlschlaeger J, Alakus H, Bohr J, Stauder MA, Worm K, Winde G, Schmid KW, Baba HA
Virchows Arch. 2007
PubMed ID: 17149612
-
Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.
Zenker M, Lehmann K, Schulz AL, Barth H, Hansmann D, Koenig R, Korinthenberg R, Kreiss-Nachtsheim M, Meinecke P, Morlot S, Mundlos S, Quante AS, Raskin S, Schnabel D, Wehner LE, Kratz CP, Horn D, Kutsche K
J Med Genet. 2007
PubMed ID: 17056636
-
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease.
Wahlstrom AM, Cutts BA, Karlsson C, Andersson KM, Liu M, Sjogren AK, Swolin B, Young SG, Bergo MO
Blood. 2007
PubMed ID: 16973961
-
KRAS and BRAF oncogenic mutations in MSS colorectal carcinoma progression.
Oliveira C, Velho S, Moutinho C, Ferreira A, Preto A, Domingo E, Capelinha AF, Duval A, Hamelin R, Machado JC, Schwartz S, Carneiro F, Seruca R
Oncogene. 2007
PubMed ID: 16953233
-
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.
Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, Segara D, Dawson AC, Kench JG, Henshall SM, Sutherland RL, Dlugosz A, Rustgi AK, Hebrok M
PLoS One. 2007
PubMed ID: 17982507
-
Enhanced lung tumor development in tobacco smoke-exposed p53 transgenic and Kras2 heterozygous deficient mice.
Yan Y, Tan Q, Wang Y, Wang D, Jin M, Gordon T, Lubet RA, You M
Inhal Toxicol. 2007
PubMed ID: 17886066
-
K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
Poehlmann A, Kuester D, Meyer F, Lippert H, Roessner A, Schneider-Stock R
Pathol Res Pract. 2007
PubMed ID: 17629419
-
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Badalian G, Barbai T, Rásó E, Derecskei K, Szendrôi M, Tímár J
Pathol Oncol Res. 2007
PubMed ID: 17607370
-
Mutational analysis of EGFR and related signaling pathway genes in lung Adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
Marks JL, McLellan MD, Zakowski MF, Lash AE, Kasai Y, Broderick S, Sarkaria IS, Pham D, Singh B, Miner TL, Fewell GA, Fulton LL, Mardis ER, Wilson RK, Kris MG, Rusch VW, Varmus H, Pao W
PLoS ONE. 2007
PubMed ID: 17487277
-
Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.
Bertola DR, Pereira AC, Brasil AS, Albano LM, Kim CA, Krieger JE
J Hum Genet. 2007
PubMed ID: 17468812
-
Highly conserved sequence of exon 15 BRAF gene and KRAS codon 12 mutation among Greek patients with colorectal cancer.
Symvoulakis EK, Zaravinos A, Panutsopulos D, Zoras O, Papalambros E, Sigala F, Spandidos DA
Int J Biol Markers. 2007
PubMed ID: 17393356
-
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Hong HH, Houle CD, Ton TV, Sills RC
Toxicol Pathol. 2007
PubMed ID: 17325976
-
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Krishnamurti U, Sasatomi E, Swalsky PA, Finkelstein SD, Ohori NP
Arch Pathol Lab Med. 2007
PubMed ID: 17227126
-
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
Jiao L, Zhu J, Hassan MM, Evans DB, Abbruzzese JL, Li D
Pancreas. 2007
PubMed ID: 17198183
-
Molecular profiles of mitogen activated protein kinase signaling pathways in orofacial development.
Singh S, Yin X, Pisano MM, Greene RM
Birth Defects Res A Clin Mol Teratol. 2007
PubMed ID: 17177285
-
EGFR and KRAS mutations as criteria for treatment with tyrosine kinase inhibitors: retro- and prospective observations in non-small-cell lung cancer.
van Zandwijk N, Mathy A, Boerrigter L, Ruijter H, Tielen I, de Jong D, Baas P, Burgers S, Nederlof P
Ann Oncol. 2007
PubMed ID: 17060486
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer.
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M
Genes Dev. 2006
PubMed ID: 17114586
-
Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.
Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL
Genes Dev. 2006
PubMed ID: 17114585
-
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.
Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA
Genes Dev. 2006
PubMed ID: 17114584
-
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells.
Zhang Z, Jiang G, Yang F, Wang J
Cancer Biol Ther. 2006
PubMed ID: 17172815
-
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
Sato H, Yazawa T, Suzuki T, Shimoyamada H, Okudela K, Ikeda M, Hamada K, Yamada-Okabe H, Yao M, Kubota Y, Takahashi T, Kamma H, Kitamura H
Am J Pathol. 2006
PubMed ID: 17071580
-
KRAS variation and risk of endometriosis.
Zhao ZZ, Nyholt DR, Le L, Martin NG, James MR, Treloar SA, Montgomery GW
Mol Hum Reprod. 2006
PubMed ID: 16973828
-
Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis.
Jang JW, Boxer RB, Chodosh LA
Mol Cell Biol. 2006
PubMed ID: 16908535
-
NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells.
Kwon O, Kim KA, Kim SO, Ha R, Oh WK, Kim MS, Kim HS, Kim GD, Kim JW, Jung M, Kim CH, Ahn JS, Kim BY
Carcinogenesis. 2006
PubMed ID: 16774937
-
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
Céspedes MV, Sancho FJ, Guerrero S, Parreño M, Casanova I, Pavón MA, Marcuello E, Trias M, Cascante M, Capellà G, Mangues R
Carcinogenesis. 2006
PubMed ID: 16679305
-
Activation of Ras/Raf protects cells from melanoma differentiation-associated gene-5-induced apoptosis.
Lin L, Su Z, Lebedeva IV, Gupta P, Boukerche H, Rai T, Barber GN, Dent P, Sarkar D, Fisher PB
Cell Death Differ. 2006
PubMed ID: 16575407
-
BRAF and KRAS mutations in prostatic adenocarcinoma.
Cho NY, Choi M, Kim BH, Cho YM, Moon KC, Kang GH
Int J Cancer. 2006
PubMed ID: 16721785
-
The consensus coding sequences of human breast and colorectal cancers.
Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE
Science. 2006
PubMed ID: 16959974
-
Growth factor-dependent AKT activation and cell migration requires the function of c-K(B)-Ras versus other cellular ras isoforms.
Liao J, Planchon SM, Wolfman JC, Wolfman A
J Biol Chem. 2006
PubMed ID: 16908523
-
APC and oncogenic KRAS are synergistic in enhancing Wnt signaling in intestinal tumor formation and progression.
Janssen KP, Alberici P, Fsihi H, Gaspar C, Breukel C, Franken P, Rosty C, Abal M, El Marjou F, Smits R, Louvard D, Fodde R, Robine S
Gastroenterology. 2006
PubMed ID: 17030180
-
Nore1B regulates TCR signaling via Ras and Carma1.
Ishiguro K, Avruch J, Landry A, Qin S, Ando T, Goto H, Xavier R
Cell Signal. 2006
PubMed ID: 16520020
-
K-Ras4B proteins are expressed in the nucleolus: Interaction with nucleolin.
Birchenall-Roberts MC, Fu T, Kim SG, Huang YK, Dambach M, Resau JH, Ruscetti FW
Biochem Biophys Res Commun. 2006
PubMed ID: 16889753
-
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16959882
-
Somatic activation of a conditional KrasG12D allele causes ineffective erythropoiesis in vivo.
Braun BS, Archard JA, Van Ziffle JA, Tuveson DA, Jacks TE, Shannon K
Blood. 2006
PubMed ID: 16720837
-
Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
Zhang W, Stabile LP, Keohavong P, Romkes M, Grandis JR, Traynor AM, Siegfried JM
J Thorac Oncol. 2006
PubMed ID: 17409930
-
Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts.
Chiaradonna F, Gaglio D, Vanoni M, Alberghina L
Biochim Biophys Acta. 2006
PubMed ID: 16987493
-
The expression of the homologue of the Caenorhabditis elegans lin-45 raf is regulated in the motile stages of the plant parasitic nematode Meloidogyne artiellia.
Cortese MR, Di Vito M, De Giorgi C
Mol Biochem Parasitol. 2006
PubMed ID: 16737746
-
Oncogenic K-ras cooperates with PML-RAR alpha to induce an acute promyelocytic leukemia-like disease.
Chan IT, Kutok JL, Williams IR, Cohen S, Moore S, Shigematsu H, Ley TJ, Akashi K, Le Beau MM, Gilliland DG
Blood. 2006
PubMed ID: 16675706
-
PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia.
Yamamoto T, Isomura M, Xu Y, Liang J, Yagasaki H, Kamachi Y, Kudo K, Kiyoi H, Naoe T, Kojma S
Leuk Res. 2006
PubMed ID: 16533526
-
BRAF, K-ras and BAT26 mutations in colorectal polyps and stool.
Jin YM, Li BJ, Qu B, Du YJ
World J Gastroenterol. 2006
PubMed ID: 16937524
-
Recurrent KRAS codon 146 mutations in human colorectal cancer.
Edkins S, O'Meara S, Parker A, Stevens C, Reis M, Jones S, Greenman C, Davies H, Dalgliesh G, Forbes S, Hunter C, Smith R, Stephens P, Goldstraw P, Nicholson A, Chan TL, Velculescu VE, Yuen ST, Leung SY, Stratton MR, Futreal PA
Cancer Biol Ther. 2006
PubMed ID: 16969076
-
Associations of Ki-ras proto-oncogene mutation and p53 gene overexpression in sporadic colorectal adenomas with demographic and clinicopathologic characteristics.
Einspahr JG, Martinez ME, Jiang R, Hsu CH, Rashid A, Bhattacharrya AK, Ahnen DJ, Jacobs ET, Houlihan PS, Webb CR, Alberts DS, Hamilton SR
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16896030
-
Advanced colorectal polyps with the molecular and morphological features of serrated polyps and adenomas: concept of a 'fusion' pathway to colorectal cancer.
Jass JR, Baker K, Zlobec I, Higuchi T, Barker M, Buchanan D, Young J
Histopathology. 2006
PubMed ID: 16879389
-
Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
Liu P, Wang Y, Vikis H, Maciag A, Wang D, Lu Y, Liu Y, You M
Nat Genet. 2006
PubMed ID: 16862160
-
A functional switch from lung cancer resistance to susceptibility at the Pas1 locus in Kras2LA2 mice.
To MD, Perez-Losada J, Mao JH, Hsu J, Jacks T, Balmain A
Nat Genet. 2006
PubMed ID: 16823377
-
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Dreissigacker U, Mueller MS, Unger M, Siegert P, Genze F, Gierschik P, Giehl K
Cell Signal. 2006
PubMed ID: 16257181
-
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr GW, Jücker M
Leuk Lymphoma. 2006
PubMed ID: 16923573
-
TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study.
Gormally E, Vineis P, Matullo G, Veglia F, Caboux E, Le Roux E, Peluso M, Garte S, Guarrera S, Munnia A, Airoldi L, Autrup H, Malaveille C, Dunning A, Overvad K, Tjønneland A, Lund E, Clavel-Chapelon F, Boeing H, Trichopoulou A, Palli D, Krogh V, Tumino R, Panico S, Bueno-de-Mesquita HB, Peeters PH, Pera G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quirós JR, Hallmans G, Day NE, Key TJ, Saracci R, Kaaks R, Riboli E, Hainaut P
Cancer Res. 2006
PubMed ID: 16818665
-
Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.
Carta C, Pantaleoni F, Bocchinfuso G, Stella L, Vasta I, Sarkozy A, Digilio C, Palleschi A, Pizzuti A, Grammatico P, Zampino G, Dallapiccola B, Gelb BD, Tartaglia M
Am J Hum Genet. 2006
PubMed ID: 16773572
-
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years.
Alsop K, Mead L, Smith LD, Royce SG, Tesoriero AA, Young JP, Haydon A, Grubb G, Giles GG, Jenkins MA, Hopper JL, Southey MC
Eur J Cancer. 2006
PubMed ID: 16765042
-
Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.
Auewarakul CU, Lauhakirti D, Tocharoentanaphol C
Eur J Haematol. 2006
PubMed ID: 16573741
-
Genetic and epigenetic alterations in lung tumors from bitransgenic Ki-rasG12C expressing mice.
Floyd HS, Jennings-Gee JE, Kock ND, Miller MS
Mol Carcinog. 2006
PubMed ID: 16482519
-
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Noda H, Kato Y, Yoshikawa H, Arai M, Togashi K, Nagai H, Konishi F, Miki Y
J Exp Clin Cancer Res. 2006
PubMed ID: 16918136
-
Quantitative trait loci for body size components in mice.
Kenney-Hunt JP, Vaughn TT, Pletscher LS, Peripato A, Routman E, Cothran K, Durand D, Norgard E, Perel C, Cheverud JM
Mamm Genome. 2006
PubMed ID: 16783635
-
Molecular detection of TP53, Ki-Ras and p16INK4A promoter methylation in plasma of patients with colorectal cancer and its association with prognosis. Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study.
Bazan V, Bruno L, Augello C, Agnese V, Calò V, Corsale S, Gargano G, Terrasi M, Schirò V, Di Fede G, Adamo V, Intrivici C, Crosta A, Rinaldi G, Latteri F, Dardanoni G, Grassi N, Valerio MR, Colucci G, Macaluso M, Russo A, Gruppo Oncologico dell'Italia Meridionale
Ann Oncol. 2006
PubMed ID: 16760301
-
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK
Mol Cell Biol. 2006
PubMed ID: 16705170
-
Mammalian K-ras2 is a corticosteroid-induced gene in vivo.
Brennan FE, Fuller PJ
Endocrinology. 2006
PubMed ID: 16543373
-
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.
Lu SL, Herrington H, Reh D, Weber S, Bornstein S, Wang D, Li AG, Tang CF, Siddiqui Y, Nord J, Andersen P, Corless CL, Wang XJ
Genes Dev. 2006
PubMed ID: 16702406
-
Follicular carcinoma presenting as autonomous functioning thyroid nodule and containing an activating mutation of the TSH receptor (T620I) and a mutation of the Ki-RAS (G12C) genes.
Niepomniszcze H, Suárez H, Pitoia F, Pignatta A, Danilowicz K, Manavela M, Elsner B, Bruno OD
Thyroid. 2006
PubMed ID: 16756473
-
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.
Raimondi AR, Vitale-Cross L, Amornphimoltham P, Gutkind JS, Molinolo A
Am J Pathol. 2006
PubMed ID: 16651631
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.
Lièvre A, Bachet JB, Le Corre D, Boige V, Landi B, Emile JF, Côté JF, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P
Cancer Res. 2006
PubMed ID: 16618717
-
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16585505
-
Distributions of five common point mutants in the human tracheal-bronchial epithelium.
Sudo H, Li-Sucholeiki XC, Marcelino LA, Gruhl AN, Zarbl H, Willey JC, Thilly WG
Mutat Res. 2006
PubMed ID: 16458330
-
Alcohol and the risk of colon and rectal cancer with mutations in the K-ras gene.
Bongaerts BW, de Goeij AF, van den Brandt PA, Weijenberg MP
Alcohol. 2006
PubMed ID: 16905440
-
Retinoblastoma family proteins: insights gained through genetic manipulation of mice.
Wikenheiser-Brokamp KA
Cell Mol Life Sci. 2006
PubMed ID: 16465443
-
Comparison of gene expression and DNA copy number changes in a murine model of lung cancer.
Sweet-Cordero A, Tseng GC, You H, Douglass M, Huey B, Albertson D, Jacks T
Genes Chromosomes Cancer. 2006
PubMed ID: 16323170
-
K-ras activation generates an inflammatory response in lung tumors.
Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK
Oncogene. 2006
PubMed ID: 16288213
-
Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.
Samowitz WS, Wolff RK, Ma KN, Andersen K, Caan B, Slattery ML
Mutat Res. 2006
PubMed ID: 16448675
-
The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
-
Prevention of lung cancer progression by bexarotene in mouse models.
Wang Y, Zhang Z, Yao R, Jia D, Wang D, Lubet RA, You M
Oncogene. 2006
PubMed ID: 16247446
-
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Ruíz-Godoy R LM, Garcia-Cuellar CM, Herrera González NE, Suchil BL, Pérez-Cárdenas E, Sácnchez-Pérez Y, Suárez-Roa ML, Meneses A
J Exp Clin Cancer Res. 2006
PubMed ID: 16761621
-
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Marchese R, Muleti A, Pasqualetti P, Bucci B, Stigliano A, Brunetti E, De Angelis M, Mazzoni G, Tocchi A, Brozzetti S
Pancreas. 2006
PubMed ID: 16552337
-
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features.
Tam IY, Chung LP, Suen WS, Wang E, Wong MC, Ho KK, Lam WK, Chiu SW, Girard L, Minna JD, Gazdar AF, Wong MP
Clin Cancer Res. 2006
PubMed ID: 16533793
-
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.
Daikoku T, Tranguch S, Trofimova IN, Dinulescu DM, Jacks T, Nikitin AY, Connolly DC, Dey SK
Cancer Res. 2006
PubMed ID: 16510568
-
Germline KRAS mutations cause Noonan syndrome.
Schubbert S, Zenker M, Rowe SL, Böll S, Klein C, Bollag G, van der Burgt I, Musante L, Kalscheuer V, Wehner LE, Nguyen H, West B, Zhang KY, Sistermans E, Rauch A, Niemeyer CM, Shannon K, Kratz CP
Nat Genet. 2006
PubMed ID: 16474405
-
Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.
Niihori T, Aoki Y, Narumi Y, Neri G, Cavé H, Verloes A, Okamoto N, Hennekam RC, Gillessen-Kaesbach G, Wieczorek D, Kavamura MI, Kurosawa K, Ohashi H, Wilson L, Heron D, Bonneau D, Corona G, Kaname T, Naritomi K, Baumann C, Matsumoto N, Kato K, Kure S, Matsubara Y
Nat Genet. 2006
PubMed ID: 16474404
-
K-ras mutations in incident sporadic colorectal adenomas.
Barry EL, Baron JA, Grau MV, Wallace K, Haile RW
Cancer. 2006
PubMed ID: 16456810
-
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
Wang Y, Zhang Z, Lubet RA, You M
Oncogene. 2006
PubMed ID: 16247444
-
Loss of heterozygosity of Kras2 gene on 12p12-13 in Chinese colon carcinoma patients.
Wan J, Li H, Li Y, Zhu ML, Zhao P
World J Gastroenterol. 2006
PubMed ID: 16534842
-
N-RAS and K-RAS gene mutations in Brazilian patients with multiple myeloma.
Ortega MM, Faria RM, Shitara ES, Assis AM, Albuquerque DM, Oliveira JS, Noguti MA, Faria JR, Costa FF, Lima CS
Leuk Lymphoma. 2006
PubMed ID: 16321859
-
Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer.
Seiden-Long IM, Brown KR, Shih W, Wigle DA, Radulovich N, Jurisica I, Tsao MS
Oncogene. 2006
PubMed ID: 16158056
-
The association between selected risk factors for pancreatic cancer and the expression of p53 and K-ras codon 12 mutations.
Fryzek JP, Garabrant DH, Schenk M, Kinnard M, Greenson JK, Sarkar FH
Int J Gastrointest Cancer. 2006
PubMed ID: 18049799
-
High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.
Krypuy M, Newnham GM, Thomas DM, Conron M, Dobrovic A
BMC Cancer. 2006
PubMed ID: 17184525
-
KRAS, p53 and BRAF gene mutations and aneuploidy in sporadic colorectal cancer progression.
Calistri D, Rengucci C, Seymour I, Leonardi E, Truini M, Malacarne D, Castagnola P, Giaretti W
Cell Oncol. 2006
PubMed ID: 16988471
-
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Wu X, Lu XH, Xu T, Qian JM, Zhao P, Guo XZ, Yang XO, Jiang WJ
Chin J Dig Dis. 2006
PubMed ID: 16808798
-
G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.
Cogoi S, Xodo LE
Nucleic Acids Res. 2006
PubMed ID: 16687659
-
Coexistence of K-ras mutations and HPV infection in colon cancer.
Buyru N, Tezol A, Dalay N
BMC Cancer. 2006
PubMed ID: 16672071
-
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Lee JW, Soung YH, Seo SH, Kim SY, Park CH, Wang YP, Park K, Nam SW, Park WS, Kim SH, Lee JY, Yoo NJ, Lee SH
Clin Cancer Res. 2006
PubMed ID: 16397024
-
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
Plowman SJ, Arends MJ, Brownstein DG, Luo F, Devenney PS, Rose L, Ritchie AM, Berry RL, Harrison DJ, Hooper ML, Patek CE
Exp Cell Res. 2006
PubMed ID: 16271715
-
Dual effect of Kras(D12) knockdown on tumorigenesis: increased immune-mediated tumor clearance and abrogation of tumor malignancy.
Smakman N, Veenendaal LM, van Diest P, Bos R, Offringa R, Borel Rinkes IH, Kranenburg O
Oncogene. 2005
PubMed ID: 16091732
-
Activating mutations and/or expression levels of tyrosine kinase receptors GRB7, RAS, and BRAF in testicular germ cell tumors.
McIntyre A, Summersgill B, Spendlove HE, Huddart R, Houlston R, Shipley J
Neoplasia. 2005
PubMed ID: 16354586
-
[Loss of heterozygosity on chromosome 12p12-13 region in Chinese patients with colon carcinoma]
Li H, Wan J, Li Y, Zhu ML, Zhao P
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16331576
-
Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?
Camps C, Sirera R, Bremnes R, Blasco A, Sancho E, Bayo P, Safont MJ, Sánchez JJ, Tarón M, Rosell R
Lung Cancer. 2005
PubMed ID: 16139926
-
Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model.
Floyd HS, Farnsworth CL, Kock ND, Mizesko MC, Little JL, Dance ST, Everitt J, Tichelaar J, Whitsett JA, Miller MS
Carcinogenesis. 2005
PubMed ID: 16051643
-
Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer?
Pretlow TP, Pretlow TG
Biochim Biophys Acta. 2005
PubMed ID: 16219426
-
Mutant KRAS in the initiation of pancreatic cancer.
Deramaudt T, Rustgi AK
Biochim Biophys Acta. 2005
PubMed ID: 16169155
-
Mouse models of K-ras-initiated carcinogenesis.
Janssen KP, Abal M, Abala M, El Marjou F, Louvard D, Robine S
Biochim Biophys Acta. 2005
PubMed ID: 16126346
-
Mutant KRAS, chromosomal instability and prognosis in colorectal cancer.
Castagnola P, Giaretti W
Biochim Biophys Acta. 2005
PubMed ID: 16112461
-
Control of colorectal metastasis formation by K-Ras.
Smakman N, Borel Rinkes IH, Voest EE, Kranenburg O
Biochim Biophys Acta. 2005
PubMed ID: 16098678
-
The differential effects of mutant p53 alleles on advanced murine lung cancer.
Jackson EL, Olive KP, Tuveson DA, Bronson R, Crowley D, Brown M, Jacks T
Cancer Res. 2005
PubMed ID: 16288016
-
Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma.
Dasgupta B, Yi Y, Hegedus B, Weber JD, Gutmann DH
Cancer Res. 2005
PubMed ID: 16267007
-
RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma.
Sharma MK, Zehnbauer BA, Watson MA, Gutmann DH
Neurology. 2005
PubMed ID: 16247081
-
Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
-
Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment.
Chakladar A, Dubeykovskiy A, Wojtukiewicz LJ, Pratap J, Lei S, Wang TC
Biochem Biophys Res Commun. 2005
PubMed ID: 16139800
-
Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo.
Zhang J, Lodish HF
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16203968
-
RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies.
Martín P, Santón A, García-Cosío M, Bellas C
Int J Oncol. 2005
PubMed ID: 16142319
-
Expression of mucin core proteins, trefoil factors, APC and p21 in subsets of colorectal polyps and cancers suggests a distinct pathway of pathogenesis of mucinous carcinoma of the colorectum.
Kim DH, Kim JW, Cho JH, Baek SH, Kakar S, Kim GE, Sleisenger MH, Kim YS
Int J Oncol. 2005
PubMed ID: 16142311
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression.
Feng YZ, Shiozawa T, Miyamoto T, Kashima H, Kurai M, Suzuki A, Konishi I
Clin Cancer Res. 2005
PubMed ID: 16144912
-
Mutations in the p53 and Ki-ras genes, microsatellite instability and site of tumor origin in colorectal cancer.
Catalano T, Curia MC, Aceto G, Verginelli F, Cascinu S, Cama A, Mariani-Costantini R, Teti D, Battista P
Oncol Rep. 2005
PubMed ID: 16077965
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib.
Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, Ince WL, Jänne PA, Januario T, Johnson DH, Klein P, Miller VA, Ostland MA, Ramies DA, Sebisanovic D, Stinson JA, Zhang YR, Seshagiri S, Hillan KJ
J Clin Oncol. 2005
PubMed ID: 16043828
-
Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia.
Goemans BF, Zwaan CM, Miller M, Zimmermann M, Harlow A, Meshinchi S, Loonen AH, Hählen K, Reinhardt D, Creutzig U, Kaspers GJ, Heinrich MC
Leukemia. 2005
PubMed ID: 16015387
-
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients.
Westra JL, Schaapveld M, Hollema H, de Boer JP, Kraak MM, de Jong D, ter Elst A, Mulder NH, Buys CH, Hofstra RM, Plukker JT
J Clin Oncol. 2005
PubMed ID: 16110022
-
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer.
Nan HM, Song YJ, Yun HY, Park JS, Kim H
World J Gastroenterol. 2005
PubMed ID: 15991278
-
A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
Loeb KR, Kostner H, Firpo E, Norwood T, D Tsuchiya K, Clurman BE, Roberts JM
Cancer Cell. 2005
PubMed ID: 16023597
-
The prevalence of PIK3CA mutations in gastric and colon cancer.
Velho S, Oliveira C, Ferreira A, Ferreira AC, Suriano G, Schwartz S, Duval A, Carneiro F, Machado JC, Hamelin R, Seruca R
Eur J Cancer. 2005
PubMed ID: 15994075
-
TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.
Le Calvez F, Mukeria A, Hunt JD, Kelm O, Hung RJ, Tanière P, Brennan P, Boffetta P, Zaridze DG, Hainaut P
Cancer Res. 2005
PubMed ID: 15958551
-
Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study.
Bazan V, Agnese V, Corsale S, Calò V, Valerio MR, Latteri MA, Vieni S, Grassi N, Cicero G, Dardanoni G, Tomasino RM, Colucci G, Gebbia N, Russo A, Gruppo Oncologico dell'Italia Meridionale (GOIM)
Ann Oncol. 2005
PubMed ID: 15923430
-
Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.
Russo A, Bazan V, Agnese V, Rodolico V, Gebbia N
Ann Oncol. 2005
PubMed ID: 15923428
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice.
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA
Cancer Cell. 2005
PubMed ID: 15894267
-
Replacement of K-Ras with H-Ras supports normal embryonic development despite inducing cardiovascular pathology in adult mice.
Potenza N, Vecchione C, Notte A, De Rienzo A, Rosica A, Bauer L, Affuso A, De Felice M, Russo T, Poulet R, Cifelli G, De Vita G, Lembo G, Di Lauro R
EMBO Rep. 2005
PubMed ID: 15864294
-
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
Embuscado EE, Laheru D, Ricci F, Yun KJ, de Boom Witzel S, Seigel A, Flickinger K, Hidalgo M, Bova GS, Iacobuzio-Donahue CA
Cancer Biol Ther. 2005
PubMed ID: 15846069
-
Murine lung tumor measurement using respiratory-gated micro-computed tomography.
Cody DD, Nelson CL, Bradley WM, Wislez M, Juroske D, Price RE, Zhou X, Bekele BN, Kurie JM
Invest Radiol. 2005
PubMed ID: 15829823
-
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Soung YH, Lee JW, Kim SY, Seo SH, Park WS, Nam SW, Song SY, Han JH, Park CK, Lee JY, Yoo NJ, Lee SH
Virchows Arch. 2005
PubMed ID: 15815931
-
K-Ras is essential for normal fetal liver erythropoiesis.
Khalaf WF, White H, Wenning MJ, Orazi A, Kapur R, Ingram DA
Blood. 2005
PubMed ID: 15644420
-
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Wang Y, Zhang Z, Lubet R, You M
Oncogene. 2005
PubMed ID: 15846305
-
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Wislez M, Spencer ML, Izzo JG, Juroske DM, Balhara K, Cody DD, Price RE, Hittelman WN, Wistuba II, Kurie JM
Cancer Res. 2005
PubMed ID: 15833854
-
A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
Wang Y, Van Becelaere K, Jiang P, Przybranowski S, Omer C, Sebolt-Leopold J
Neoplasia. 2005
PubMed ID: 15967111
-
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Hsieh JS, Lin SR, Chang MY, Chen FM, Lu CY, Huang TJ, Huang YS, Huang CJ, Wang JY
Am Surg. 2005
PubMed ID: 15943410
-
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.
Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, Campuzano V, Barbacid M
Cancer Cell. 2005
PubMed ID: 15837621
-
Genotyping of patients with sporadic and radiation-associated meningiomas.
Sadetzki S, Flint-Richter P, Starinsky S, Novikov I, Lerman Y, Goldman B, Friedman E
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 15824172
-
Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors.
Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH
Cancer Res. 2005
PubMed ID: 15805275
-
Genotype phenotype correlations in Israeli colorectal cancer patients.
Starinsky S, Figer A, Ben-Asher E, Geva R, Flex D, Fidder HH, Zidan J, Lancet D, Friedman E
Int J Cancer. 2005
PubMed ID: 15523694
-
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
Shigematsu H, Lin L, Takahashi T, Nomura M, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Shimizu N, Fujisawa T, Feng Z, Roth JA, Herz J, Minna JD, Gazdar AF
J Natl Cancer Inst. 2005
PubMed ID: 15741570
-
K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.
Yao R, Wang Y, D'Agostini F, Izzotti A, Lubet RA, You M, De Flora S
Exp Lung Res. 2005
PubMed ID: 15824025
-
Characterization of two protein-binding sites in the second intron of the mouse K-ras gene.
Chen B, Wang Y, You M
Exp Lung Res. 2005
PubMed ID: 15824020
-
Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility.
Wang M, Wang Y, You M
Exp Lung Res. 2005
PubMed ID: 15824019
-
K-ras mutation influences macroscopic features of gastric carcinoma.
Yashiro M, Nishioka N, Hirakawa K
J Surg Res. 2005
PubMed ID: 15734482
-
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
Yamada S, Yashiro M, Maeda K, Nishiguchi Y, Hirakawa K
Int J Cancer. 2005
PubMed ID: 15514939
-
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.
Vaqué JP, Navascues J, Shiio Y, Laiho M, Ajenjo N, Mauleon I, Matallanas D, Crespo P, León J
J Biol Chem. 2005
PubMed ID: 15528212
-
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Su YH, Wang M, Aiamkitsumrit B, Brenner DE, Block TM
Cancer Biomark. 2005
PubMed ID: 17192038
-
Deciphering cancer complexities in genetically engineered mice.
Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869764
-
Mouse models of human non-small-cell lung cancer: raising the bar.
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869760
-
Ductal pancreatic cancer in humans and mice.
Tuveson DA, Hingorani SR
Cold Spring Harb Symp Quant Biol. 2005
PubMed ID: 16869739
-
KRAS transitions and villous growth in colorectal adenomas.
Risio M, Malacarne D, Giaretti W
Cell Oncol. 2005
PubMed ID: 16373972
-
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Lüchtenborg M, Weijenberg MP, Wark PA, Saritas AM, Roemen GM, van Muijen GN, de Bruïne AP, van den Brandt PA, de Goeij AF
BMC Cancer. 2005
PubMed ID: 16356174
-
Cyclooxygenase-2 is a target of KRASD12, which facilitates the outgrowth of murine C26 colorectal liver metastases.
Smakman N, Kranenburg O, Vogten JM, Bloemendaal AL, van Diest P, Borel Rinkes IH
Clin Cancer Res. 2005
PubMed ID: 15671526
-
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Dasgupta B, Li W, Perry A, Gutmann DH
Cancer Res. 2005
PubMed ID: 15665300
-
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T
Nat Med. 2005
PubMed ID: 15619626
-
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis.
Sweet-Cordero A, Mukherjee S, Subramanian A, You H, Roix JJ, Ladd-Acosta C, Mesirov J, Golub TR, Jacks T
Nat Genet. 2005
PubMed ID: 15608639
-
Characterization of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies.
Williams JM, Savage CO
J Am Soc Nephrol. 2005
PubMed ID: 15548565
-
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Pan ZZ, Wan DS, Chen G, Li LR, Lu ZH, Huang BJ
World J Gastroenterol. 2004
PubMed ID: 15534934
-
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
Takahashi C, Contreras B, Bronson RT, Loda M, Ewen ME
Mol Cell Biol. 2004
PubMed ID: 15542848
-
Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia.
Ritter M, Kim TD, Lisske P, Thiede C, Schaich M, Neubauer A
Haematologica. 2004
PubMed ID: 15531466
-
BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status.
Yang S, Farraye FA, Mack C, Posnik O, O'Brien MJ
Am J Surg Pathol. 2004
PubMed ID: 15489648
-
ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure.
Vaziri ND, Liang K
Am J Physiol Renal Physiol. 2004
PubMed ID: 15280162
-
Low frequency of NRAS and KRAS2 gene mutations in childhood myelodysplastic syndromes.
Jekic B, Novakovic I, Lukovic L, Kuzmanovic M, Popovic B, Pastar I, Milasin J, Bunjevacki G, Bunjevacki V
Cancer Genet Cytogenet. 2004
PubMed ID: 15474158
-
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Reid TS, Terry KL, Casey PJ, Beese LS
J Mol Biol. 2004
PubMed ID: 15451670
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
Loukopoulos P, Kanetaka K, Takamura M, Shibata T, Sakamoto M, Hirohashi S
Pancreas. 2004
PubMed ID: 15367885
-
H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells.
Zisoulis DG, Kansas GS
J Biol Chem. 2004
PubMed ID: 15262995
-
Protein kinase B, P34cdc2 kinase, and p21 ras GTP-binding in kidneys of aging rats.
Parekh VV, Falcone JC, Wills-Frank LA, Joshua IG, Dholakia JN, Passmore JC
Exp Biol Med (Maywood). 2004
PubMed ID: 15337841
-
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Taback B, Bilchik AJ, Saha S, Nakayama T, Wiese DA, Turner RR, Kuo CT, Hoon DS
Int J Cancer. 2004
PubMed ID: 15221969
-
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
Klampfer L, Huang J, Sasazuki T, Shirasawa S, Augenlicht L
J Biol Chem. 2004
PubMed ID: 15213223
-
Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.
Caulin C, Nguyen T, Longley MA, Zhou Z, Wang XJ, Roop DR
Cancer Res. 2004
PubMed ID: 15289303
-
Usefulness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Talar-Wojnarowska R, Gasiorowska A, Smolarz B, Romanowicz-Makowska H, Strzelczyk J, Janiak A, Kulig A, Malecka-Panas E
J Physiol Pharmacol. 2004
PubMed ID: 15608367
-
Molecular genetic analysis of ovarian serous cystadenomas.
Cheng EJ, Kurman RJ, Wang M, Oldt R, Wang BG, Berman DM, Shih IeM
Lab Invest. 2004
PubMed ID: 15077125
-
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Manenti G, Galbiati F, Giannì-Barrera R, Pettinicchio A, Acevedo A, Dragani TA
Oncogene. 2004
PubMed ID: 15064703
-
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor.
Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G
J Biol Chem. 2004
PubMed ID: 15037631
-
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Zhou GX, Huang JF, Li ZS, Xu GM, Liu F, Zhang H
World J Gastroenterol. 2004
PubMed ID: 15112354
-
P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
Jassem J, Jassem E, Jakóbkiewicz-Banecka J, Rzyman W, Badzio A, Dziadziuszko R, Kobierska-Gulida G, Szymanowska A, Skrzypski M, Zylicz M
Cancer. 2004
PubMed ID: 15112277
-
Ras gene mutations in patients with acute myeloid leukaemia and exposure to chemical agents.
Barletta E, Gorini G, Vineis P, Miligi L, Davico L, Mugnai G, Ciolli S, Leoni F, Bertini M, Matullo G, Costantini AS
Carcinogenesis. 2004
PubMed ID: 14688017
-
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
Reifenberger J, Knobbe CB, Sterzinger AA, Blaschke B, Schulte KW, Ruzicka T, Reifenberger G
Int J Cancer. 2004
PubMed ID: 14961576
-
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.
Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T
Cancer Cell. 2004
PubMed ID: 15093544
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Normal p21Ras/MAP kinase pathway expression and function in PBMC from patients with polycystic ovary disease.
Buchs A, Chagag P, Weiss M, Kish E, Levinson R, Aharoni D, Rapoport MJ
Int J Mol Med. 2004
PubMed ID: 15010862
-
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Ren YX, Xu GM, Li ZS, Song YG
World J Gastroenterol. 2004
PubMed ID: 15040037
-
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
Murray NR, Jamieson L, Yu W, Zhang J, Gökmen-Polar Y, Sier D, Anastasiadis P, Gatalica Z, Thompson EA, Fields AP
J Cell Biol. 2004
PubMed ID: 15024028
-
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer.
Mammas IN, Zafiropoulos A, Koumantakis E, Sifakis S, Spandidos DA
Gynecol Oncol. 2004
PubMed ID: 14984964
-
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
-
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG
J Clin Invest. 2004
PubMed ID: 14966563
-
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.
Chan IT, Kutok JL, Williams IR, Cohen S, Kelly L, Shigematsu H, Johnson L, Akashi K, Tuveson DA, Jacks T, Gilliland DG
J Clin Invest. 2004
PubMed ID: 14966562
-
Mutations of BRAF and KRAS2 in the development of Barrett's adenocarcinoma.
Sommerer F, Vieth M, Markwarth A, Röhrich K, Vomschloss S, May A, Ell C, Stolte M, Hengge UR, Wittekind C, Tannapfel A
Oncogene. 2004
PubMed ID: 14724583
-
Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder.
Braun BS, Tuveson DA, Kong N, Le DT, Kogan SC, Rozmus J, Le Beau MM, Jacks TE, Shannon KM
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14699048
-
Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.
Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA
Int J Dev Biol. 2004
PubMed ID: 15558479
-
Ki-ras mutational analysis in rat follicular-cell proliferative lesions of the thyroid gland induced by radioactive iodine and potassium perchlorate.
Fernández-Santos JM, De-Miguel M, González-Cámpora R, Salguero-Villadiego M, Cabrera JJ, Galera-Davidson H
J Endocrinol Invest. 2004
PubMed ID: 15053237
-
[Regulation of [12Asp]K-ras4B on transcriptional activity of estrogen receptor in endometrial carcinoma HEC-1A cell lines]
Gui LM, Wei LH, Xu MX, Wang JL, Zhong YC, Li XP, Tu Z, Sun PM, Ma DL
Zhonghua Fu Chan Ke Za Zhi. 2004
PubMed ID: 14989985
-
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Ton TV, Hong HH, Anna CH, Dunnick JK, Devereux TR, Sills RC, Kim Y
Toxicol Pathol. 2004
PubMed ID: 14713543
-
A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization.
Chung YJ, Jonkers J, Kitson H, Fiegler H, Humphray S, Scott C, Hunt S, Yu Y, Nishijima I, Velds A, Holstege H, Carter N, Bradley A
Genome Res. 2004
PubMed ID: 14707179
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
p53 expression and p21 expression are mutually exclusive in esophageal squamous cell carcinoma.
Hamada M, Naomoto Y, Shirakawa Y, Yamatsuji T, Noma K, Motoki T, Nobuhisa T, Okawa T, Haisa M, Gunduz M, Matsuoka J, Tanaka N
Oncol Rep. 2004
PubMed ID: 14654903
-
Loss of heterozygosity of chromosome 12p does not correlate with KRAS mutation in non-small cell lung cancer.
Uchiyama M, Usami N, Kondo M, Mori S, Ito M, Ito G, Yoshioka H, Imaizumi M, Ueda Y, Takahashi M, Minna JD, Shimokata K, Sekido Y
Int J Cancer. 2003
PubMed ID: 14601056
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.
Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA
Genes Dev. 2003
PubMed ID: 14681207
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA
Cancer Cell. 2003
PubMed ID: 14706336
-
While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.
Plowman SJ, Williamson DJ, O'Sullivan MJ, Doig J, Ritchie AM, Harrison DJ, Melton DW, Arends MJ, Hooper ML, Patek CE
Mol Cell Biol. 2003
PubMed ID: 14645534
-
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers.
Kim IJ, Park JH, Kang HC, Shin Y, Park HW, Park HR, Ku JL, Lim SB, Park JG
Hum Genet. 2003
PubMed ID: 14513361
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
-
Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression.
Klampfer L, Huang J, Corner G, Mariadason J, Arango D, Sasazuki T, Shirasawa S, Augenlicht L
J Biol Chem. 2003
PubMed ID: 12972432
-
Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer.
Alguacil J, Porta M, Kauppinen T, Malats N, Kogevinas M, Carrato A, PANKRAS II Study Group
Int J Cancer. 2003
PubMed ID: 14520703
-
Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
Zhang Z, Futamura M, Vikis HG, Wang M, Li J, Wang Y, Guan KL, You M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14583591
-
High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
Fiordalisi JJ, Johnson RL, Weinbaum CA, Sakabe K, Chen Z, Casey PJ, Cox AD
J Biol Chem. 2003
PubMed ID: 12882980
-
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Takahashi M, Mutoh M, Shoji Y, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K
Oncogene. 2003
PubMed ID: 14576830
-
Phosphatidylinositol 3'-kinase-dependent activation of renal mesangial cell Ki-Ras and ERK by advanced glycation end products.
Xu D, Kyriakis JM
J Biol Chem. 2003
PubMed ID: 12871951
-
BRAF and KRAS mutations in stomach cancer.
Lee SH, Lee JW, Soung YH, Kim HS, Park WS, Kim SY, Lee JH, Park JY, Cho YG, Kim CJ, Nam SW, Kim SH, Lee JY, Yoo NJ
Oncogene. 2003
PubMed ID: 14534542
-
[Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]
Lu QF, Bai M, Zhang HJ, Li JC, Xiao CF, Chen S, Wu TC
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2003
PubMed ID: 14761400
-
Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status.
Lüttges J, Neumann S, Jesnowski R, Borries V, Löhr M, Klöppel G
Pancreas. 2003
PubMed ID: 14508142
-
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
James RM, Arends MJ, Plowman SJ, Brooks DG, Miles CG, West JD, Patek CE
Mol Cancer Res. 2003
PubMed ID: 14517344
-
K-ras regulates the steady-state expression of matrix metalloproteinase 2 in fibroblasts.
Liao J, Wolfman JC, Wolfman A
J Biol Chem. 2003
PubMed ID: 12805379
-
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Guerra C, Mijimolle N, Dhawahir A, Dubus P, Barradas M, Serrano M, Campuzano V, Barbacid M
Cancer Cell. 2003
PubMed ID: 12957286
-
Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.
Calvert RJ, Tepper S, Diwan BA, Anderson LM, Kritchevsky D
Biochem Pharmacol. 2003
PubMed ID: 12907238
-
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.
Vos MD, Ellis CA, Elam C, Ulku AS, Taylor BJ, Clark GJ
J Biol Chem. 2003
PubMed ID: 12732644
-
RASSF1A promoter methylation and Kras2 mutations in non small cell lung cancer.
Li J, Zhang Z, Dai Z, Popkie AP, Plass C, Morrison C, Wang Y, You M
Neoplasia. 2003
PubMed ID: 14511407
-
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
Keohavong P, Lan Q, Gao WM, DeMarini DM, Mass MJ, Li XM, Roop BC, Weissfeld J, Tian D, Mumford JL
Lung Cancer. 2003
PubMed ID: 12826308
-
Fine mapping and identification of candidate pulmonary adenoma susceptibility 1 genes using advanced intercross lines.
Wang M, Lemon WJ, Liu G, Wang Y, Iraqi FA, Malkinson AM, You M
Cancer Res. 2003
PubMed ID: 12810665
-
Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea.
Shimada Y, Nishimura M, Kakinuma S, Ogiu T, Fujimoto H, Kubo A, Nagai J, Kobayash K, Tano K, Yoshinaga S, Bhakat KK
Int J Radiat Biol. 2003
PubMed ID: 12963544
-
Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas.
Patrikis MI, Bryan EJ, Thomas NA, Rice GE, Quinn MA, Baker MS, Campbell IG
Mol Carcinog. 2003
PubMed ID: 12766905
-
Ca2+/calmodulin binds and dissociates K-RasB from membrane.
Sidhu RS, Clough RR, Bhullar RP
Biochem Biophys Res Commun. 2003
PubMed ID: 12727204
-
Transitions and transversions in Ki-ras gene in colorectal cancers in Mexican patients.
Segura-Uribe J, Santiago-Payán H, Quintero A
Tumori. 2003
PubMed ID: 12908779
-
Regulation of the p21Ras-MAP kinase pathway by factor VIIa.
Versteeg HH, Bresser HL, Spek CA, Richel DJ, Van Deventer SJ, Peppelenbosch MP
J Thromb Haemost. 2003
PubMed ID: 12871370
-
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.
Grippo PJ, Nowlin PS, Demeure MJ, Longnecker DS, Sandgren EP
Cancer Res. 2003
PubMed ID: 12727811
-
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
Brembeck FH, Schreiber FS, Deramaudt TB, Craig L, Rhoades B, Swain G, Grippo P, Stoffers DA, Silberg DG, Rustgi AK
Cancer Res. 2003
PubMed ID: 12727809
-
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Shimotake T, Aoi S, Tomiyama H, Iwai N
J Pediatr Surg. 2003
PubMed ID: 12720172
-
Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.
Shimizu K, Okada M, Nagai K, Fukada Y
J Biol Chem. 2003
PubMed ID: 12594205
-
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma.
Singer G, Oldt R, Cohen Y, Wang BG, Sidransky D, Kurman RJ, Shih IeM
J Natl Cancer Inst. 2003
PubMed ID: 12644542
-
Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China.
Hoshida Y, Hongyo T, Jia X, He Y, Hasui K, Dong Z, Luo WJ, Ham MF, Nomura T, Aozasa K
Cancer Sci. 2003
PubMed ID: 12824925
-
Met receptor overexpression and oncogenic Ki-ras mutation cooperate to enhance tumorigenicity of colon cancer cells in vivo.
Long IS, Han K, Li M, Shirasawa S, Sasazuki T, Johnston M, Tsao MS
Mol Cancer Res. 2003
PubMed ID: 12651912
-
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs.
Schiekofer S, Andrassy M, Chen J, Rudofsky G, Schneider J, Wendt T, Stefan N, Humpert P, Fritsche A, Stumvoll M, Schleicher E, Häring HU, Nawroth PP, Bierhaus A
Diabetes. 2003
PubMed ID: 12606501
-
LOH of chromosome 12p correlates with Kras2 mutation in non-small cell lung cancer.
Li J, Zhang Z, Dai Z, Plass C, Morrison C, Wang Y, Wiest JS, Anderson MW, You M
Oncogene. 2003
PubMed ID: 12606951
-
Specific T-cell immunity against Ki-ras peptides in patients with pancreatic and colorectal cancers.
Shono Y, Tanimura H, Iwahashi M, Tsunoda T, Tani M, Tanaka H, Matsuda K, Yamaue H
Br J Cancer. 2003
PubMed ID: 12592366
-
Exploring environmental causes of altered ras effects: fragmentation plus integration?
Porta M, Ayude D, Alguacil J, Jariod M
Mol Carcinog. 2003
PubMed ID: 12557259
-
Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response.
Maria DA, Manenti G, Galbiati F, Ribeiro OG, Cabrera WH, Barrera RG, Pettinicchio A, De Franco M, Starobinas N, Siqueira M, Dragani TA, Ibañez OM
Oncogene. 2003
PubMed ID: 12545163
-
Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing.
Denicourt C, Kozak CA, Rassart E
J Virol. 2003
PubMed ID: 12477808
-
Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling.
Stockand JD, Meszaros JG
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12388314
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
-
Reaction path of protein farnesyltransferase at atomic resolution.
Long SB, Casey PJ, Beese LS
Nature. 2002
PubMed ID: 12374986
-
Constitutive activation of proto-oncogen protein p21 induces cell cycle arrest in the G1 phase in contact-inhibited vascular endothelial cells.
Suzuki E, Nishimatsu H, Nagata D, Satonaka H, Goto A, Omata M, Fujita T, Nagai R, Hirata Y
Hypertens Res. 2002
PubMed ID: 12452332
-
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression]
Timofeeva OA, Gorshkova EV, Levashova ZB, Kobzev VF, Filipenko ML, Kaledin VI, Merkulova TI
Mol Biol (Mosk). 2002
PubMed ID: 12391845
-
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12093899
-
Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells.
Kim BY, Gaynor RB, Song K, Dritschilo A, Jung M
Oncogene. 2002
PubMed ID: 12085227
-
A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival.
Toyooka S, Tsukuda K, Mizuta M, Soh J, Shirakawa K, Shimizu K, Shimizu N
Am J Gastroenterol. 2002
PubMed ID: 12135058
-
Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.
Calvert RJ, Ramakrishna G, Tepper S, Diwan BA, Anderson LM, Kritchevsky D
Biochem Pharmacol. 2002
PubMed ID: 12106604
-
Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.
Laghi L, Orbetegli O, Bianchi P, Zerbi A, Di Carlo V, Boland CR, Malesci A
Oncogene. 2002
PubMed ID: 12082617
-
Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR.
McKinzie PB, Parsons BL
Mutat Res. 2002
PubMed ID: 12034322
-
K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
van Engeland M, Roemen GM, Brink M, Pachen MM, Weijenberg MP, de Bruïne AP, Arends JW, van den Brandt PA, de Goeij AF, Herman JG
Oncogene. 2002
PubMed ID: 12032847
-
Clinical significance of expression of p21 and p53 proteins and proliferating cell nuclear antigen in pancreatic cancer.
Dang CX, Han Y, Qin ZY, Wang YJ
Hepatobiliary Pancreat Dis Int. 2002
PubMed ID: 14612290
-
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells.
Jiang X, Sorkin A
Mol Biol Cell. 2002
PubMed ID: 12006650
-
SmgGDS displays differential binding and exchange activity towards different Ras isoforms.
Vikis HG, Stewart S, Guan KL
Oncogene. 2002
PubMed ID: 11948427
-
K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development.
Matsui T, Kinoshita T, Morikawa Y, Tohya K, Katsuki M, Ito Y, Kamiya A, Miyajima A
EMBO J. 2002
PubMed ID: 11867530
-
Overexpression of p53 protein and point mutation of K-ras genes in primary carcinoma of the small intestine.
Nishiyama K, Yao T, Yonemasu H, Yamaguchi K, Tanaka M, Tsuneyoshi M
Oncol Rep. 2002
PubMed ID: 11836595
-
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J
Oncogene. 2002
PubMed ID: 11857081
-
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.
Costa RM, Federov NB, Kogan JH, Murphy GG, Stern J, Ohno M, Kucherlapati R, Jacks T, Silva AJ
Nature. 2002
PubMed ID: 11793011
-
p21 and p53 Immunostaining and survival following systemic chemotherapy for urothelial cancer.
Jankevicius F, Goebell P, Kushima M, Schulz WA, Ackermann R, Schmitz-Dräger BJ
Urol Int. 2002
PubMed ID: 12372883
-
Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.
Weihrauch M, Bader M, Lehnert G, Koch B, Wittekind C, Wrbitzky R, Tannapfel A
Environ Mol Mutagen. 2002
PubMed ID: 12211074
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ, Whitsett JA, Koretsky A, Varmus HE
Genes Dev. 2001
PubMed ID: 11751631
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA
Genes Dev. 2001
PubMed ID: 11751630
-
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Kamai T, Arai K, Koga F, Abe H, Nakanishi K, Kambara T, Furuya N, Tsujii T, Yoshida KI
BJU Int. 2001
PubMed ID: 11851621
-
Activated Ras modifies the proliferative response of rheumatoid synovial cells to TNF-alpha and TGF-alpha.
Kitasato H, Noda M, Akahoshi T, Okamoto R, Koshino T, Murakami Y, Inoue M, Kawai S
Inflamm Res. 2001
PubMed ID: 11822784
-
Genotypic and phenotypic progression in endometrial tumorigenesis: determining when defects in DNA mismatch repair and KRAS2 occur.
Cohn DE, Mutch DG, Herzog TJ, Rader JS, Dintzis SM, Gersell DJ, Todd CR, Goodfellow PJ
Genes Chromosomes Cancer. 2001
PubMed ID: 11746970
-
Differences in in vitro invasive capacity induced by differences in Ki-Ras protein mutations.
Al-Mulla F, MacKenzie EM
J Pathol. 2001
PubMed ID: 11745690
-
Inducible, pharmacogenetic approaches to the study of learning and memory.
Ohno M, Frankland PW, Chen AP, Costa RM, Silva AJ
Nat Neurosci. 2001
PubMed ID: 11713472
-
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.
Villalonga P, López-Alcalá C, Bosch M, Chiloeches A, Rocamora N, Gil J, Marais R, Marshall CJ, Bachs O, Agell N
Mol Cell Biol. 2001
PubMed ID: 11585916
-
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Meuwissen R, Linn SC, van der Valk M, Mooi WJ, Berns A
Oncogene. 2001
PubMed ID: 11641780
-
Oncogenic levels of mitogen-activated protein kinase (MAPK) signaling of the dinucleotide KRAS2 mutations G12F and GG12-13VC.
Feldser DM, Kern SE
Hum Mutat. 2001
PubMed ID: 11668624
-
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Ahrendt SA, Decker PA, Alawi EA, Zhu Yr YR, Sanchez-Cespedes M, Yang SC, Haasler GB, Kajdacsy-Balla A, Demeure MJ, Sidransky D
Cancer. 2001
PubMed ID: 11745231
-
Wildtype Kras2 can inhibit lung carcinogenesis in mice.
Zhang Z, Wang Y, Vikis HG, Johnson L, Liu G, Li J, Anderson MW, Sills RC, Hong HL, Devereux TR, Jacks T, Guan KL, You M
Nat Genet. 2001
PubMed ID: 11528387
-
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Bezieau S, Devilder MC, Avet-Loiseau H, Mellerin MP, Puthier D, Pennarun E, Rapp MJ, Harousseau JL, Moisan JP, Bataille R
Hum Mutat. 2001
PubMed ID: 11524732
-
Differential activation of the Rac pathway by Ha-Ras and K-Ras.
Walsh AB, Bar-Sagi D
J Biol Chem. 2001
PubMed ID: 11278702
-
Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas.
Walentinsson A, Levan G
Cancer Lett. 2001
PubMed ID: 11295286
-
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Johnson L, Mercer K, Greenbaum D, Bronson RT, Crowley D, Tuveson DA, Jacks T
Nature. 2001
PubMed ID: 11323676
-
Haploid loss of Ki-ras delays mammary tumor progression in C3 (1)/SV40 Tag transgenic mice.
Liu ML, Shibata MA, Von Lintig FC, Wang W, Cassenaer S, Boss GR, Green JE
Oncogene. 2001
PubMed ID: 11360188
-
Genetic linkage of nuclear morphology of mouse lung tumors to the Kras-2 locus.
Tripodis N, Demant P
Exp Lung Res. 2001
PubMed ID: 11293323
-
Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2.
de Hoog CL, Koehler JA, Goldstein MD, Taylor P, Figeys D, Moran MF
Mol Cell Biol. 2001
PubMed ID: 11238945
-
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
-
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
-
K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
Ohigashi H, Ishikawa O, Sasaki Y, Yamada T, Furukawa H, Imaoka S, Kasugai T, Ishiguro S, Ueda K, Miyoshi Y, Nakamura Y
Arch Surg. 2000
PubMed ID: 11115351
-
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
-
Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor.
Clyde-Smith J, Silins G, Gartside M, Grimmond S, Etheridge M, Apolloni A, Hayward N, Hancock JF
J Biol Chem. 2000
PubMed ID: 10918068
-
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
-
Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.
Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T
J Biol Chem. 2000
PubMed ID: 10882715
-
Population-based mapping of pulmonary adenoma susceptibility 1 locus.
Dragani TA, Hirohashi S, Juji T, Kawajiri K, Kihara M, Ono-Kihara M, Manenti G, Nomoto T, Sugimura H, Genka K, Yokota J, Takahashi T, Mitsudomi T, Nagao M
Cancer Res. 2000
PubMed ID: 11016621
-
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Bissonnette M, Khare S, von Lintig FC, Wali RK, Nguyen L, Zhang Y, Hart J, Skarosi S, Varki N, Boss GR, Brasitus TA
Cancer Res. 2000
PubMed ID: 10969813
-
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
-
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M
Oncogene. 2000
PubMed ID: 10871846
-
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Li W, Han M, Guan KL
Genes Dev. 2000
PubMed ID: 10783161
-
Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons.
Vogel KS, El-Afandi M, Parada LF
Mol Cell Neurosci. 2000
PubMed ID: 10845775
-
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Reuther GW, Der CJ
Curr Opin Cell Biol. 2000
PubMed ID: 10712923
-
Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma.
Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R
Eur J Biochem. 1999
PubMed ID: 10542052
-
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
Tanoguchi K, Yaegashi N, Jiko K, Maekawa A, Sato S, Yajima A
Tohoku J Exp Med. 1999
PubMed ID: 10775052
-
Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector.
Adams JM, Harris AW, Strasser A, Ogilvy S, Cory S
Oncogene. 1999
PubMed ID: 10498879
-
Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.
Rebollo A, Pérez-Sala D, Martínez-A C
Oncogene. 1999
PubMed ID: 10490827
-
Small GTPases and cell cycle regulation.
Marshall CJ
Biochem Soc Trans. 1999
PubMed ID: 10917603
-
Linkage disequilibrium and physical mapping of Pas1 in mice.
Manenti G, Stafford A, De Gregorio L, Gariboldi M, Falvella FS, Avner P, Dragani TA
Genome Res. 1999
PubMed ID: 10413402
-
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ, Young SG
J Biol Chem. 1999
PubMed ID: 10085069
-
Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression.
Al-Mulla F, Milner-White EJ, Going JJ, Birnie GD
J Pathol. 1999
PubMed ID: 10398103
-
Low frequency of Ras gene mutation in spontaneous and gamma-ray-induced thymic lymphomas of scid mice.
Nishimura M, Wakana S, Kakinuma S, Mita K, Ishii H, Kobayashi S, Ogiu T, Sado T, Shimada Y
Radiat Res. 1999
PubMed ID: 9952298
-
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
-
Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
Jones-Bolin SE, Johansson E, Palmisano WA, Anderson MW, Wiest JS, Belinsky SA
Carcinogenesis. 1998
PubMed ID: 9744549
-
Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation.
Sithanandam G, Ramakrishna G, Diwan BA, Anderson LM
Oncogene. 1998
PubMed ID: 9696043
-
The structural basis of the activation of Ras by Sos.
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J
Nature. 1998
PubMed ID: 9690470
-
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
Sieburth DS, Sun Q, Han M
Cell. 1998
PubMed ID: 9674433
-
Molecular comparison of human and mouse pulmonary adenocarcinomas.
Malkinson AM
Exp Lung Res. 1998
PubMed ID: 9659582
-
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Lin L, Festing MF, Devereux TR, Crist KA, Christiansen SC, Wang Y, Yang A, Svenson K, Paigen B, Malkinson AM, You M
Exp Lung Res. 1998
PubMed ID: 9659579
-
Characterization of murine BCAT genes: Bcat1, a c-Myc target, and its homolog, Bcat2.
Ben-Yosef T, Eden A, Benvenisty N
Mamm Genome. 1998
PubMed ID: 9657861
-
Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22.
Ben-Porath I, Kozak CA, Benvenisty N
Genomics. 1998
PubMed ID: 9615230
-
Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain.
Misawa H, Ohtsubo M, Copeland NG, Gilbert DJ, Jenkins NA, Yoshimura A
Biochem Biophys Res Commun. 1998
PubMed ID: 9514948
-
Interferon gamma activation of Raf-1 is Jak1-dependent and p21ras-independent.
Sakatsume M, Stancato LF, David M, Silvennoinen O, Saharinen P, Pierce J, Larner AC, Finbloom DS
J Biol Chem. 1998
PubMed ID: 9446616
-
No turning, a mouse mutation causing left-right and axial patterning defects.
Melloy PG, Ewart JL, Cohen MF, Desmond ME, Kuehn MR, Lo CW
Dev Biol. 1998
PubMed ID: 9466889
-
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
-
Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.
Tamma SM, Chirmule N, McCloskey TW, Oyaizu N, Kalyanaraman VS, Pahwa S
Clin Immunol Immunopathol. 1997
PubMed ID: 9344703
-
Developmentally-regulated expression of murine K-ras isoforms.
Pells S, Divjak M, Romanowski P, Impey H, Hawkins NJ, Clarke AR, Hooper ML, Williamson DJ
Oncogene. 1997
PubMed ID: 9362444
-
K-ras is an essential gene in the mouse with partial functional overlap with N-ras.
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T
Genes Dev. 1997
PubMed ID: 9334313
-
Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6.
Isomoto S, Horio Y, Matsumoto S, Kondo C, Yamada M, Gilbert DJ, Copeland NG, Jenkins NA, Kurachi Y
Mamm Genome. 1997
PubMed ID: 9321483
-
Mapping and characterization of three YAC clones containing TTAGGG arrays.
Yen CH, Hohman C, Elliott RW
Mamm Genome. 1997
PubMed ID: 9321475
-
K-ras is essential for the development of the mouse embryo.
Koera K, Nakamura K, Nakao K, Miyoshi J, Toyoshima K, Hatta T, Otani H, Aiba A, Katsuki M
Oncogene. 1997
PubMed ID: 9294608
-
CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.
Tamma SM, Chirmule N, Yagura H, Oyaizu N, Kalyanaraman V, Pahwa S
Blood. 1997
PubMed ID: 9269777
-
Ras effectors and their role in mitogenesis and oncogenesis.
Joneson T, Bar-Sagi D
J Mol Med. 1997
PubMed ID: 9297626
-
Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains.
Pataer A, Nishimura M, Kamoto T, Ichioka K, Sato M, Hiai H
Cancer Res. 1997
PubMed ID: 9230199
-
N-ras protein: frequent quantitative and qualitative changes occur in human colorectal carcinomas.
Kim K, Kuo T, Cai J, Shuja S, Murnane MJ
Int J Cancer. 1997
PubMed ID: 9180144
-
Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice.
Matzinger SA, Chen B, Wang Y, Crist KA, Stoner GD, Kelloff GJ, Lubet RA, You M
Gene. 1997
PubMed ID: 9133601
-
Signal transduction by the neurotrophin receptors.
Kaplan DR, Miller FD
Curr Opin Cell Biol. 1997
PubMed ID: 9069267
-
The complexity of Raf-1 regulation.
Morrison DK, Cutler RE
Curr Opin Cell Biol. 1997
PubMed ID: 9069260
-
Mapping of the mouse actin capping protein alpha subunit genes and pseudogenes.
Hart MC, Korshunova YO, Cooper JA
Genomics. 1997
PubMed ID: 9119363
-
Mapping of six germ-cell-specific genes to mouse chromosomes.
Matsui M, Ichihara H, Kobayashi S, Tanaka H, Tsuchida J, Nozaki M, Yoshimura Y, Nojima H, Rochelle JM, Nishimune Y, Taketo MM, Seldin MF
Mamm Genome. 1997
PubMed ID: 9337410
-
Pas1 is a common lung cancer susceptibility locus in three mouse strains.
Manenti G, Gariboldi M, Fiorino A, Zedda AI, Pierotti MA, Dragani TA
Mamm Genome. 1997
PubMed ID: 9337390
-
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation.
Meersseman G, Verschueren K, Nelles L, Blumenstock C, Kraft H, Wuytens G, Remacle J, Kozak CA, Tylzanowski P, Niehrs C, Huylebroeck D
Mech Dev. 1997
PubMed ID: 9076683
-
Biochemical characterization of a novel KRAS insertion mutation from a human leukemia.
Bollag G, Adler F, elMasry N, McCabe PC, Conner E, Thompson P, McCormick F, Shannon K
J Biol Chem. 1996
PubMed ID: 8955068
-
Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse.
Fijneman RJ, de Vries SS, Jansen RC, Demant P
Nat Genet. 1996
PubMed ID: 8944028
-
Primary mediastinal and testicular seminomas: a comparison of K-ras-2 gene sequence and p53 immunoperoxidase analysis of 26 cases.
Przygodzki RM, Moran CA, Suster S, Khan MA, Swalsky PA, Bakker A, Koss MN, Finkelstein SD
Hum Pathol. 1996
PubMed ID: 8816895
-
Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation.
Hsu DK, Guo Y, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Peifley KA, Winkles JA
J Biol Chem. 1996
PubMed ID: 8662936
-
Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12.
Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA
Genomics. 1996
PubMed ID: 8661067
-
H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice.
Manjanatha MG, Li EE, Fu PP, Heflich RH
J Toxicol Environ Health. 1996
PubMed ID: 8598575
-
Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits.
Nagasawa M, Sakimura K, Mori KJ, Bedell MA, Copeland NG, Jenkins NA, Mishina M
Brain Res Mol Brain Res. 1996
PubMed ID: 9011744
-
Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression.
Force WR, Walter BN, Hession C, Tizard R, Kozak CA, Browning JL, Ware CF
J Immunol. 1995
PubMed ID: 7594541
-
Epithelial sodium channel genes Scnn1b and Scnn1g are closely linked on distal mouse chromosome 7.
Brooker DR, Kozak CA, Kleyman TR
Genomics. 1995
PubMed ID: 8575777
-
Different susceptibility to lung tumorigenesis in mice with an identical Kras2 intron 2.
Manenti G, Falvella FS, Gariboldi M, Dragani TA, Pierotti MA
Genomics. 1995
PubMed ID: 8666392
-
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.
Lee KH, Lee JS, Suh C, Kim SW, Kim SB, Lee JH, Lee MS, Park MY, Sun HS, Kim SH
Cancer. 1995
PubMed ID: 7773929
-
High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
Massey TE, Devereux TR, Maronpot RR, Foley JF, Anderson MW
Carcinogenesis. 1995
PubMed ID: 7767966
-
Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.
Puranam KL, Kennington E, Sait SN, Shows TB, Rochelle JM, Seldin MF, Blackshear PJ
Genomics. 1995
PubMed ID: 7607686
-
Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.
Wang KY, Chen KC, Chiang CP, Kuo MY
J Oral Pathol Med. 1995
PubMed ID: 7776260
-
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
Immunogenetics. 1995
PubMed ID: 7590978
-
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
Spaargaren M, Bischoff JR
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7809086
-
New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strains.
Cheah YC, Nadeau JH, Pugh S, Paigen B
Mamm Genome. 1994
PubMed ID: 7894156
-
Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19.
Devereux TR, Wiseman RW, Kaplan N, Garren S, Foley JF, White CM, Anna C, Watson MA, Patel A, Jarchow S
Mamm Genome. 1994
PubMed ID: 7894154
-
Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.
Hofer F, Fields S, Schneider C, Martin GS
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7972015
-
Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.
Johnson KR, Cook SA, Davisson MT
Mamm Genome. 1994
PubMed ID: 7873877
-
At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice.
Festing MF, Yang A, Malkinson AM
Genet Res. 1994
PubMed ID: 7813906
-
Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors.
Higinbotham KG, Rice JM, Buzard GS, Perantoni AO
Oncogene. 1994
PubMed ID: 8058308
-
Kras-2 alleles, mutations, and lung tumor susceptibility in the mouse--an evaluation.
Fijneman RJ, Ophoff RA, Hart AA, Demant P
Oncogene. 1994
PubMed ID: 8152802
-
Differential expression of protooncogenes in human germ cell tumors of the testis.
Shuin T, Misaki H, Kubota Y, Yao M, Hosaka M
Cancer. 1994
PubMed ID: 7908857
-
The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex.
Ziegler SF, Levin SD, Johnson L, Copeland NG, Gilbert DJ, Jenkins NA, Baker E, Sutherland GR, Feldhaus AL, Ramsdell F
J Immunol. 1994
PubMed ID: 8301128
-
Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ, Svenson KL, Sparkes RS, Lusis AJ
Genomics. 1993
PubMed ID: 8288233
-
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.
Shultz LD, Schweitzer PA, Rajan TV, Yi T, Ihle JN, Matthews RJ, Thomas ML, Beier DR
Cell. 1993
PubMed ID: 8324828
-
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J
Science. 1993
PubMed ID: 8316835
-
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Imamura N, Kuramoto A, Ishihara H, Shimizu S
Am J Hematol. 1993
PubMed ID: 7916576
-
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
-
A major susceptibility locus to murine lung carcinogenesis maps on chromosome 6.
Gariboldi M, Manenti G, Canzian F, Falvella FS, Radice MT, Pierotti MA, Della Porta G, Binelli G, Dragani TA
Nat Genet. 1993
PubMed ID: 8499946
-
Detection of point mutations in the Kirsten-ras oncogene provides evidence for the multicentricity of pancreatic carcinoma.
Motojima K, Urano T, Nagata Y, Shiku H, Tsurifune T, Kanematsu T
Ann Surg. 1993
PubMed ID: 8439212
-
Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes.
Santos J, Pellicer A
Cytogenet Cell Genet. 1993
PubMed ID: 8095010
-
Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system.
Furuichi T, Simon-Chazottes D, Fujino I, Yamada N, Hasegawa M, Miyawaki A, Yoshikawa S, Guénet JL, Mikoshiba K
Receptors Channels. 1993
PubMed ID: 8081710
-
ras gene activation and aberrant expression of keratin K13 in ultraviolet B radiation-induced epidermal neoplasias of mouse skin.
Sutter C, Strickland PT, Mukhtar H, Agarwal R, Winter H, Schweizer J
Mol Carcinog. 1993
PubMed ID: 7688967
-
Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats.
Jansen H, van Tol A, Auwerx J, Skretting G, Staels B
Biochim Biophys Acta. 1992
PubMed ID: 1420288
-
The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.
Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, Copeland NG, Rabbitts TH
J Mol Biol. 1992
PubMed ID: 1507224
-
Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
Lord PG, Hardaker KJ, Loughlin JM, Marsden AM, Orton TC
Carcinogenesis. 1992
PubMed ID: 1499088
-
Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.
You M, Wang Y, Stoner G, You L, Maronpot R, Reynolds SH, Anderson M
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1352876
-
Comparison of Ki-ras gene mutation among simultaneously occurring multiple urethan-induced lung tumors in individual mice.
Ohmori H, Abe T, Hirano H, Murakami T, Katoh T, Gotoh S, Kido M, Kuroiwa A, Nomura T, Higashi K
Carcinogenesis. 1992
PubMed ID: 1586998
-
Localization of the gene for a third G protein beta-subunit to mouse chromosome 6 near Raf-1.
Danciger M, Chakraborti A, Farber DB, Kozak CA
Genomics. 1992
PubMed ID: 1572642
-
Identification of a novel gene, Vin-1, in murine leukemia virus-induced T-cell leukemias by provirus insertional mutagenesis.
Tremblay PJ, Kozak CA, Jolicoeur P
J Virol. 1992
PubMed ID: 1738193
-
Multilocus markers for mouse genome analysis: PCR amplification based on single primers of arbitrary nucleotide sequence.
Nadeau JH, Bedigian HG, Bouchard G, Denial T, Kosowsky M, Norberg R, Pugh S, Sargeant E, Turner R, Paigen B
Mamm Genome. 1992
PubMed ID: 1617215
-
Detection of a rare point mutation in Ki-ras of a human bladder cancer xenograft by polymerase chain reaction and direct sequencing.
Grimmond SM, Raghavan D, Russell PJ
Urol Res. 1992
PubMed ID: 1553789
-
Localization of mouse parathyroid hormone-like peptide gene (Pthlh) to distal chromosome 6 using interspecific backcross mice and in situ hybridization.
Seldin MF, Mattei MG, Hendy GN
Cytogenet Cell Genet. 1992
PubMed ID: 1354597
-
H-DNA and Z-DNA in the mouse c-Ki-ras promoter.
Pestov DG, Dayn A, Siyanova EYu, George DL, Mirkin SM
Nucleic Acids Res. 1991
PubMed ID: 1754390
-
Molecular genetic linkage maps of mouse chromosomes 4 and 6.
Bahary N, Zorich G, Pachter JE, Leibel RL, Friedman JM
Genomics. 1991
PubMed ID: 1684952
-
The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man.
Levan G, Szpirer J, Szpirer C, Klinga K, Hanson C, Islam MQ
Genomics. 1991
PubMed ID: 1889815
-
Oncogene expression in the liver tissue of patients with nonneoplastic liver disease.
Haritani H, Esumi M, Uchida T, Shikata T
Cancer. 1991
PubMed ID: 2015559
-
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Slebos RJ, Habets GG, Evers SG, Mooi WJ, Rodenhuis S
Int J Cancer. 1991
PubMed ID: 1850383
-
Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids.
Yasue M, Serikawa T, Yamada J
Cytogenet Cell Genet. 1991
PubMed ID: 1914521
-
The gene coding for the kidney androgen-regulated protein (Kap), maps between the Gapd and Kras-2 genes on mouse chromosome 6.
Melanitou E, Simon-Chazottes D, Guénet JL, Rougeon F
Mamm Genome. 1991
PubMed ID: 1686731
-
Identification and applications of repetitive probes for gene mapping in the mouse.
Siracusa LD, Jenkins NA, Copeland NG
Genetics. 1991
PubMed ID: 1673105
-
Structure, chromosome mapping and expression of the murine Fgf-6 gene.
de Lapeyriere O, Rosnet O, Benharroch D, Raybaud F, Marchetto S, Planche J, Galland F, Mattei MG, Copeland NG, Jenkins NA
Oncogene. 1990
PubMed ID: 2193291
-
Localization of the rhodopsin gene to the distal half of mouse chromosome 6.
Elliott RW, Sparkes RS, Mohandas T, Grant SG, McGinnis JF
Genomics. 1990
PubMed ID: 2341153
-
Alterations of mouse proto-oncogenes in sarcomas induced after transplantation of human tumors in athymic nude mice.
Yuasa Y, Yamazaki H, Maruo K, Ueyama Y, Shibuya M, Tamaoki N
Jpn J Cancer Res. 1990
PubMed ID: 2114387
-
Prp (proline-rich protein) genes linked to markers Es-12 (esterase-12), Ea-10 (erythrocyte alloantigen), and loci on distal mouse chromosome 6.
Azen EA, Davisson MT, Cherry M, Taylor BA
Genomics. 1989
PubMed ID: 2613230
-
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas.
Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, Bos JL
Nucleic Acids Res. 1988
PubMed ID: 3047672
-
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes.
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M
Cell. 1988
PubMed ID: 2453289
-
In situ localization of murine c-Ki-ras-2 oncogene: preliminary evidence for conservation of telomeric territory of oncogenes?
Martin-DeLeon PA, Picciano SR
Somat Cell Mol Genet. 1988
PubMed ID: 3279541
-
Binding of ras p21 to bands 4.2 and 6 of human erythrocyte membranes.
Tanimoto T, Hoshijima M, Kawata M, Yamamoto K, Ohmori T, Shiku H, Nakano H, Takai Y
FEBS Lett. 1988
PubMed ID: 3276554
-
The rat gene map.
Szpirer C, Szpirer J, Islam MQ, Levan G
Curr Top Microbiol Immunol. 1988
PubMed ID: 3416641
-
KRAS2 as a genetic marker for lung tumor susceptibility in inbred mice.
Ryan J, Barker PE, Nesbitt MN, Ruddle FH
J Natl Cancer Inst. 1987
PubMed ID: 2891865
-
Chromosomal localization of the met proto-oncogene in the mouse and cat genome.
Dean M, Kozak C, Robbins J, Callahan R, O'Brien S, Vande Woude GF
Genomics. 1987
PubMed ID: 3692486
-
The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231.
Kozma SC, Bogaard ME, Buser K, Saurer SM, Bos JL, Groner B, Hynes NE
Nucleic Acids Res. 1987
PubMed ID: 3627975
-
A c-ras-Ki oncogene is activated, amplified and overexpressed in a human osteosarcoma cell line.
Nardeux PC, Daya-Grosjean L, Landin RM, Andéol Y, Suàrez HG
Biochem Biophys Res Commun. 1987
PubMed ID: 3476115
-
Structural and functional characterization of the promoter region of the mouse c-Ki-ras gene.
Hoffman EK, Trusko SP, Freeman N, George DL
Mol Cell Biol. 1987
PubMed ID: 3614201
-
The c-K-ras gene and human cancer (review).
Kahn S, Yamamoto F, Almoguera C, Winter E, Forrester K, Jordano J, Perucho M
Anticancer Res. 1987
PubMed ID: 3310850
-
Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.
McMahon G, Davis E, Wogan GN
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3110778
-
Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line.
Deng GR, Lu YY, Chen SM, Miao J, Lu GR, Li H, Cai H, Xu XL, E Z, Liu PN
Cancer Res. 1987
PubMed ID: 3034404
-
c-K-ras mutations in human carcinomas occur preferentially in codon 12.
Yanez L, Groffen J, Valenzuela DM
Oncogene. 1987
PubMed ID: 3330777
-
An EcoRI restriction fragment length polymorphism at the KRAS2 locus on mouse chromosome 6.
Ryan J, Barker PE, Ruddle FH
Nucleic Acids Res. 1986
PubMed ID: 2878419
-
Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.
Tahira T, Hayashi K, Ochiai M, Tsuchida N, Nagao M, Sugimura T
Mol Cell Biol. 1986
PubMed ID: 3023884
-
Nucleotide sequence of exon I of the rat c-K-ras gene.
Iritani A, Katayama N, Tahira T, Hayashi K, Tsuchida N
Bull Tokyo Med Dent Univ. 1986
PubMed ID: 3009041
-
An endogenous mouse mammary tumor virus genome common in inbred mouse strains is located on chromosome 6.
Robbins JM, Gallahan D, Hogg E, Kozak C, Callahan R
J Virol. 1986
PubMed ID: 3003402
-
Assignment of RAS proto-oncogenes in Chinese hamsters: implications for mammalian gene linkage conservation and neoplasia.
Stallings RL, Crawford BD, Black RJ, Chang EH
Cytogenet Cell Genet. 1986
PubMed ID: 3022995
-
Loss of the normal N-ras allele in a mouse thymic lymphoma induced by a chemical carcinogen.
Guerrero I, Villasante A, Corces V, Pellicer A
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3865197
-
Essential region for transforming activity of human c-Ha-ras-1.
Sekiya T, Tokunaga A, Fushimi M
Jpn J Cancer Res. 1985
PubMed ID: 3932274
-
Structure and expression of amplified cKi-ras gene sequences in Y1 mouse adrenal tumor cells.
George DL, Scott AF, Trusko S, Glick B, Ford E, Dorney DJ
EMBO J. 1985
PubMed ID: 4006913
-
Chromosomal localization of three human ras genes by in situ molecular hybridization.
Popescu NC, Amsbaugh SC, DiPaolo JA, Tronick SR, Aaronson SA, Swan DC
Somat Cell Mol Genet. 1985
PubMed ID: 3856955
-
Activation of the c-K-ras oncogene in a human pancreas carcinoma.
Hirai H, Okabe T, Anraku Y, Fujisawa M, Urabe A, Takaku F
Biochem Biophys Res Commun. 1985
PubMed ID: 3855240
-
Regional mapping of cKi-ras proto-oncogene on mouse chromosome 6 by in situ hybridization.
Cahilly LA, George DL
Cytogenet Cell Genet. 1985
PubMed ID: 4006517
-
Structure and mechanisms of activation of c-K-ras oncogenes in human lung cancer.
Yamamoto F, Nakano H, Neville C, Perucho M
Prog Med Virol. 1985
PubMed ID: 3895297
-
Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X.
Szpirer J, Defeo-Jones D, Ellis RW, Levan G, Szpirer C
Somat Cell Mol Genet. 1985
PubMed ID: 3856333
-
Activation of a human c-K-ras oncogene.
Yamamoto F, Perucho M
Nucleic Acids Res. 1984
PubMed ID: 6096811
-
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
Taya Y, Hosogai K, Hirohashi S, Shimosato Y, Tsuchiya R, Tsuchida N, Fushimi M, Sekiya T, Nishimura S
EMBO J. 1984
PubMed ID: 6098458
-
Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.
Guerrero I, Villasante A, Corces V, Pellicer A
Science. 1984
PubMed ID: 6474169
-
Human colon carcinoma Ki-ras2 oncogene and its corresponding proto-oncogene.
McCoy MS, Bargmann CI, Weinberg RA
Mol Cell Biol. 1984
PubMed ID: 6092920
-
Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12.
Sakaguchi AY, Zabel BU, Grzeschik KH, Law ML, Ellis RW, Scolnick EM, Naylor SL
Mol Cell Biol. 1984
PubMed ID: 6328282
-
Amplified DNA in Y1 mouse adrenal tumor cells: isolation of cDNAs complementary to an amplified c-Ki-ras gene and localization of homologous sequences to mouse chromosome 6.
George DL, Scott AF, de Martinville B, Francke U
Nucleic Acids Res. 1984
PubMed ID: 6546797
-
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Della Porta G, Barbacid M
Science. 1984
PubMed ID: 6695174
-
Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.
Cytogenet Cell Genet. 1984
PubMed ID: 6690234
-
Expression of H-Y antigen by female mice carrying Sxr.
Simpson E, McLaren A, Chandler P, Tomonari K
Transplantation. 1984
PubMed ID: 6364482
-
Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.
Sakaguchi AY, Lalley PA, Zabel BU, Ellis RW, Scolnick EM, Naylor SL
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6320193
-
Isolation of transforming sequences of two human lung carcinomas: structural and functional analysis of the activated c-K-ras oncogenes.
Nakano H, Yamamoto F, Neville C, Evans D, Mizuno T, Perucho M
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6320174
-
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations.
Capon DJ, Seeburg PH, McGrath JP, Hayflick JS, Edman U, Levinson AD, Goeddel DV
Nature. 1983
PubMed ID: 6308467
-
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene.
McGrath JP, Capon DJ, Smith DH, Chen EY, Seeburg PH, Goeddel DV, Levinson AD
Nature. 1983
PubMed ID: 6308466
-
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.
Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparowsky E, Goldfarb M, Wigler M
Nature. 1983
PubMed ID: 6308465
-
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
Yuasa Y, Srivastava SK, Dunn CY, Rhim JS, Reddy EP, Aaronson SA
Nature. 1983
PubMed ID: 6866079
-
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells.
Schwab M, Alitalo K, Varmus HE, Bishop JM, George D
Nature. 1983
PubMed ID: 6304530
-
Characterization of a human colon/lung carcinoma oncogene.
McCoy MS, Toole JJ, Cunningham JM, Chang EH, Lowy DR, Weinberg RA
Nature. 1983
PubMed ID: 6298638
-
Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.
Müller R, Verma IM, Adamson ED
EMBO J. 1983
PubMed ID: 6641714
-
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
Ellis RW, Defeo D, Shih TY, Gonda MA, Young HA, Tsuchida N, Lowy DR, Scolnick EM
Nature. 1981
PubMed ID: 6265801
-
Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses.
Scolnick EM, Papageorge AG, Shih TY
Proc Natl Acad Sci U S A. 1979
PubMed ID: 228288
-
The publication is not currently in our database, click on the link below to see it on pubmed.
PubMed ID:
Model Organism Phenotype Links
|
Relevant resources: