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KIFC1

Gene Description:   kinesin family member C1; kinesin-like protein KIFC1-like Synonyms:   KNSL2, LOC100502766, MGC1202, HSET, MGC149736, KIFC1, MGC149737 Orthologs:   Human KIFC1 (protein-coding), Mouse LOC100502766 (protein-coding)   Sources Sources Human-Mouse: MGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

(Human) GRCh37 - chr6:33359313..33377701 (18.39 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:34012611..34027606 (14.99 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas           no data no data no data no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for KIFC1: The KIFC1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs KIFC1   NDC80   IntAct  empirical  20360068  KIFC1   RG9MTD1   IntAct  empirical  18984158  KIFC1   RANBP2   IntAct  empirical  20360068

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 16   Mitotic sister chromatid segregation GO:0000070 Nucleotide binding GO:0000166 Microtubule motor activity GO:0003777 ATP binding GO:0005524 Nucleus GO:0005634 Cytoplasm GO:0005737 Early endosome GO:0005769 Microtubule organizing center GO:0005815 Spindle GO:0005819 Cytoskeleton GO:0005856 Microtubule GO:0005874 Microtubule associated complex GO:0005875 Microtubule-based movement GO:0007018 Cell cycle GO:0007049 Blood coagulation GO:0007596 Cell division GO:0051301

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 16 Mitotic sister chromatid segregation GO:0000070 Nucleotide binding GO:0000166 Microtubule motor activity GO:0003777 ATP binding GO:0005524 Nucleus GO:0005634 Cytoplasm GO:0005737 Early endosome GO:0005769 Microtubule organizing center GO:0005815 Spindle GO:0005819 Cytoskeleton GO:0005856 Microtubule GO:0005874 Microtubule associated complex GO:0005875 Microtubule-based movement GO:0007018 Cell cycle GO:0007049 Blood coagulation GO:0007596 Cell division GO:0051301

Type 1 Diabetes Publications: 1

• The presence of kinesin superfamily motor proteins KIFC1 and KIF17 in normal and pathological human placenta.
  Sati L, Seval-Celik Y, Unek G, Korgun ET, Demir R
  Placenta. 2009
  PubMed ID: 19679349
   
  

Publications: 24

• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Chromosome congression in the absence of kinetochore fibres.
  Cai S, O'Connell CB, Khodjakov A, Walczak CE
  Nat Cell Biol. 2009
  PubMed ID: 19525938
   
  
• The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
  Grinberg-Rashi H, Ofek E, Perelman M, Skarda J, Yaron P, Hajdúch M, Jacob-Hirsch J, Amariglio N, Krupsky M, Simansky DA, Ram Z, Pfeffer R, Galernter I, Steinberg DM, Ben-Dov I, Rechavi G, Izraeli S
  Clin Cancer Res. 2009
  PubMed ID: 19190132
   
  
• Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules.
  Cai S, Weaver LN, Ems-McClung SC, Walczak CE
  Mol Biol Cell. 2009
  PubMed ID: 19116309
   
  
• Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
  Wang B, Malik R, Nigg EA, Körner R
  Anal Chem. 2008
  PubMed ID: 19007248
   
  
• Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry.
  Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M
  J Proteome Res. 2008
  PubMed ID: 19367708
   
  
• Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.
  Ansari KI, Mishra BP, Mandal SS
  Biochim Biophys Acta. 2008
  PubMed ID: 18082152
   
  
• Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
  Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD
  J Proteome Res. 2007
  PubMed ID: 17924679
   
  
• Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.
  Nath S, Bananis E, Sarkar S, Stockert RJ, Sperry AO, Murray JW, Wolkoff AW
  Mol Biol Cell. 2007
  PubMed ID: 17360972
   
  
• Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c.
  Al-Bassam J, Roger B, Halpain S, Milligan RA
  Cell Motil Cytoskeleton. 2007
  PubMed ID: 17326138
   
  
• Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
  Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
  Cell. 2006
  PubMed ID: 17081983
   
  
• Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication.
  Christodoulou A, Lederer CW, Surrey T, Vernos I, Santama N
  J Cell Sci. 2006
  PubMed ID: 16638812
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.
  Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W
  Mol Biol Cell. 2005
  PubMed ID: 15843429
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• The DNA sequence and analysis of human chromosome 6.
  Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
  Nature. 2003
  PubMed ID: 14574404
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• All kinesin superfamily protein, KIF, genes in mouse and human.
  Miki H, Setou M, Kaneshiro K, Hirokawa N
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11416179
   
  
• Identification of isoforms of a mitotic motor in mammalian spermatogenesis.
  Navolanic PM, Sperry AO
  Biol Reprod. 2000
  PubMed ID: 10775188
   
  
• Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS).
  Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A
  Immunogenetics. 1999
  PubMed ID: 10369922
   
  
• Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
  Yang Z, Hanlon DW, Marszalek JR, Goldstein LS
  Genomics. 1997
  PubMed ID: 9339368
   
  
• KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.
  Saito N, Okada Y, Noda Y, Kinoshita Y, Kondo S, Hirokawa N
  Neuron. 1997
  PubMed ID: 9115736
   
  
• Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region.
  Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K
  Immunogenetics. 1994
  PubMed ID: 8276466
   
  

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