ARG1

Summary Top Help

Gene Description:

arginase, liver

Synonyms:

AI256583, ARG1, PGIF, AI, Arg1, Arg-1

Orthologs:

Human ARG1 (protein-coding), Mouse Arg1 (protein-coding), Rat Arg1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr6:131894284..131905472 (11.19 kb) View in Genome Browser

(Mouse) NCBIM37 - chr10:24635013..24647276 (12.26 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:20998894..21011275 (12.38 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ARG1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ARG1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: 2

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 39

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 232

Diabetes-induced vascular dysfunction involves arginase I.
Romero MJ, Iddings JA, Platt DH, Ali MI, Cederbaum SD, Stepp DW, Caldwell RB, Caldwell RW
Am J Physiol Heart Circ Physiol. 2012
PubMed ID: 22058149
The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.
Fang Y, Mu J, Ma Y, Ma D, Fu D, Shen X
Mol Cell Biochem. 2012
PubMed ID: 21800051
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.
Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR
Immunity. 2011
PubMed ID: 22195744
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.
Altun M, Kramer HB, Willems LI, McDermott JL, Leach CA, Goldenberg SJ, Kumar KG, Konietzny R, Fischer R, Kogan E, Mackeen MM, McGouran J, Khoronenkova SV, Parsons JL, Dianov GL, Nicholson B, Kessler BM
Chem Biol. 2011
PubMed ID: 22118674
Selective inhibition and augmentation of alternative macrophage activation by progesterone.
Menzies FM, Henriquez FL, Alexander J, Roberts CW
Immunology. 2011
PubMed ID: 21977998
Arginine depletion as a mechanism for the immune privilege of corneal allografts.
Fu H, Khan A, Coe D, Zaher S, Chai JG, Kropf P, Müller I, Larkin DF, George AJ
Eur J Immunol. 2011
PubMed ID: 21805470
Crystal structures of complexes with cobalt-reconstituted human arginase I.
D'Antonio EL, Christianson DW
Biochemistry. 2011
PubMed ID: 21870783
Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.
Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY
PLoS Pathog. 2011
PubMed ID: 21931552
Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase.
Sharda DR, Yu S, Ray M, Squadrito ML, De Palma M, Wynn TA, Morris SM, Hankey PA
J Immunol. 2011
PubMed ID: 21810604
Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2, iNOS and arginase-1 expression.
Shweash M, Adrienne McGachy H, Schroeder J, Neamatallah T, Bryant CE, Millington O, Mottram JC, Alexander J, Plevin R
Mol Immunol. 2011
PubMed ID: 21664694
S-nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase.
Dunn J, Gutbrod S, Webb A, Pak A, Jandu SK, Bhunia A, Berkowitz DE, Santhanam L
Mol Cell Biochem. 2011
PubMed ID: 21533769
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA, Pineda-Torra I
Circ Res. 2011
PubMed ID: 21757649
Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation.
Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, Dallegri F, Bronte V, Ferrini S, Barbieri O
J Leukoc Biol. 2011
PubMed ID: 21330347
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM
Science. 2011
PubMed ID: 21436399
Expression of IL-10-triggered STAT3-dependent IL-4Rα is required for induction of arginase 1 in visceral leishmaniasis.
Biswas A, Bhattacharya A, Kar S, Das PK
Eur J Immunol. 2011
PubMed ID: 21413004
Association of serum arginase I with oxidative stress in a healthy population.
Ogino K, Takahashi N, Takigawa T, Obase Y, Wang DH
Free Radic Res. 2011
PubMed ID: 20942574
A genome-wide association study on obesity and obesity-related traits.
Wang K, Li WD, Zhang CK, Wang Z, Glessner JT, Grant SF, Zhao H, Hakonarson H, Price RA
PLoS One. 2011
PubMed ID: 21552555
Cerebral changes occurring in arginase and dimethylarginine dimethylaminohydrolase (DDAH) in a rat model of sleeping sickness.
Amrouni D, Meiller A, Gautier-Sauvigné S, Piraud M, Bouteille B, Vincendeau P, Buguet A, Cespuglio R
PLoS One. 2011
PubMed ID: 21408057
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, Scott JA
Respir Res. 2011
PubMed ID: 21291525
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously.
Newman J, Pearce L, Lesburg CA, Strickland C, Peat TS
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011
PubMed ID: 21206033
Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children.
Salam MT, Bastain TM, Rappaport EB, Islam T, Berhane K, Gauderman WJ, Gilliland FD
Allergy. 2010
PubMed ID: 21039601
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Regulatory Haplotypes in ARG1 are Associated with Altered Bronchodilator Response.
Duan QL, Gaume BR, Hawkins GA, Himes BE, Bleecker ER, Klanderman B, Irvin CG, Peters SP, Meyers DA, Hanrahan JP, Lima JJ, Litonjua AA, Tantisira KG, Liggett SB
Am J Respir Crit Care Med. 2010
PubMed ID: 20851928
Inhibition of arginase activity ameliorates L-arginine-induced acute pancreatitis in rats.
Biczó G, Hegyi P, Berczi S, Dósa S, Hracskó Z, Varga IS, Iványi B, Venglovecz V, Wittmann T, Takács T, Rakonczay Z
Pancreas. 2010
PubMed ID: 20697209
Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms.
Yan BC, Gong C, Song J, Krausz T, Tretiakova M, Hyjek E, Al-Ahmadie H, Alves V, Xiao SY, Anders RA, Hart JA
Am J Surg Pathol. 2010
PubMed ID: 20661013
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells.
Morán JM, Ortiz-Ortiz MA, Ruiz-Mesa LM, Niso-Santano M, Bravosanpedro JM, Sánchez RG, González-Polo RA, Fuentes JM
Nitric Oxide. 2010
PubMed ID: 20388547
Network organization of the human autophagy system.
Behrends C, Sowa ME, Gygi SP, Harper JW
Nature. 2010
PubMed ID: 20562859
Direct relationship between levels of TNF-alpha expression and endothelial dysfunction in reperfusion injury.
Zhang C, Wu J, Xu X, Potter BJ, Gao X
Basic Res Cardiol. 2010
PubMed ID: 20091314
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
Herbert DR, Orekov T, Roloson A, Ilies M, Perkins C, O'Brien W, Cederbaum S, Christianson DW, Zimmermann N, Rothenberg ME, Finkelman FD
J Immunol. 2010
PubMed ID: 20483789
Human eosinophil granulocytes do not express the enzyme arginase.
Luckner-Minden C, Fischer I, Langhans CD, Schiller M, Kropf P, Müller I, Hohlfeld JM, Ho AD, Munder M
J Leukoc Biol. 2010
PubMed ID: 20200399
Insulin resistance induced by a high-fructose diet potentiates thioacetamide hepatotoxicity.
Pooranaperundevi M, Sumiyabanu MS, Viswanathan P, Sundarapandiyan R, Anuradha CV
Singapore Med J. 2010
PubMed ID: 20593143
Inhibition of human arginase I by substrate and product analogues.
Di Costanzo L, Ilies M, Thorn KJ, Christianson DW
Arch Biochem Biophys. 2010
PubMed ID: 20153713
Association of haplotypes of inflammation-related genes with gastric preneoplastic lesions in African Americans and Caucasians.
Zabaleta J, Camargo MC, Ritchie MD, Piazuelo MB, Sierra RA, Turner SD, Delgado A, Fontham ET, Schneider BG, Correa P, Ochoa AC
Int J Cancer. 2010
PubMed ID: 20473875
Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen synthesis in human and rat pulmonary fibroblasts.
Warnken M, Haag S, Matthiesen S, Juergens UR, Racké K
Naunyn Schmiedebergs Arch Pharmacol. 2010
PubMed ID: 20107769
Thrombin induces endothelial arginase through AP-1 activation.
Zhu W, Chandrasekharan UM, Bandyopadhyay S, Morris SM, DiCorleto PE, Kashyap VS
Am J Physiol Cell Physiol. 2010
PubMed ID: 20032511
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
Vonk JM, Postma DS, Maarsingh H, Bruinenberg M, Koppelman GH, Meurs H
Pharmacogenet Genomics. 2010
PubMed ID: 20124949
Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species.
O'Brien J, Lyons T, Monks J, Lucia MS, Wilson RS, Hines L, Man YG, Borges V, Schedin P
Am J Pathol. 2010
PubMed ID: 20110414
Human embryonic stem cells suppress T cell responses via arginase I-dependent mechanism.
Yachimovich-Cohen N, Even-Ram S, Shufaro Y, Rachmilewitz J, Reubinoff B
J Immunol. 2010
PubMed ID: 20032293
Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.
Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ
Sci Signal. 2010
PubMed ID: 20716764
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
Gannon PO, Godin-Ethier J, Hassler M, Delvoye N, Aversa M, Poisson AO, Péant B, Alam Fahmy M, Saad F, Lapointe R, Mes-Masson AM
PLoS One. 2010
PubMed ID: 20711410
Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.
Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M
PLoS Genet. 2010
PubMed ID: 20084116
Association of rs2781666 G/T polymorphism of arginase I gene with myocardial infarction in Tunisian male population.
Sediri Y, Kallel A, Ben Ali S, Omar S, Mourali MS, Elasmi M, Taieb SH, Sanhaji H, Feki M, Mechmeche R, Jemaa R, Kaabachi N
Clin Biochem. 2010
PubMed ID: 19896478
Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Sankaralingam S, Xu H, Davidge ST
Cardiovasc Res. 2010
PubMed ID: 19684035
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
Hertecant JL, Al-Gazali LI, Karuvantevida NS, Ali BR
Saudi Med J. 2009
PubMed ID: 19936428
Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase.
Chen B, Calvert AE, Cui H, Nelin LD
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19801451
Misregulation of the arginase pathway in tissues of spontaneously hypertensive rats.
Bagnost T, Berthelot A, Alvergnas M, Miguet-Alfonsi C, André C, Guillaume Y, Demougeot C
Hypertens Res. 2009
PubMed ID: 19763131
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Extracellular activation of arginase-1 decreases enterocyte inducible nitric oxide synthase activity during systemic inflammation.
Miki K, Kumar A, Yang R, Killeen ME, Delude RL
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19713467
Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Sankaralingam S, Xu H, Jiang Y, Sawamura T, Davidge ST
Hypertension. 2009
PubMed ID: 19687346
Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat.
Belik J, Stevens D, Pan J, Shehnaz D, Ibrahim C, Kantores C, Ivanovska J, Grasemann H, Jankov RP
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19666777
Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats.
Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, Berkowitz DE
J Appl Physiol. 2009
PubMed ID: 19661445
IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer.
Rotondo R, Barisione G, Mastracci L, Grossi F, Orengo AM, Costa R, Truini M, Fabbi M, Ferrini S, Barbieri O
Int J Cancer. 2009
PubMed ID: 19431148
Arginase activity mediates retinal inflammation in endotoxin-induced uveitis.
Zhang W, Baban B, Rojas M, Tofigh S, Virmani SK, Patel C, Behzadian MA, Romero MJ, Caldwell RW, Caldwell RB
Am J Pathol. 2009
PubMed ID: 19590038
Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo.
Deng K, He H, Qiu J, Lorber B, Bryson JB, Filbin MT
J Neurosci. 2009
PubMed ID: 19641117
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity.
Schreiber T, Ehlers S, Heitmann L, Rausch A, Mages J, Murray PJ, Lang R, Hölscher C
J Immunol. 2009
PubMed ID: 19561100
Recent advances in arginine metabolism: roles and regulation of the arginases.
Morris SM
Br J Pharmacol. 2009
PubMed ID: 19508396
AT(1) receptor activation regulates the mRNA expression of CAT1, CAT2, arginase-1, and DDAH2 in preglomerular vessels from angiotensin II hypertensive rats.
Hultström M, Helle F, Iversen BM
Am J Physiol Renal Physiol. 2009
PubMed ID: 19386725
Characterization of arginase 1 gene polymorphisms in the Algerian population and association with blood pressure.
Meroufel D, Dumont J, Médiène-Benchekor S, Benhammamouch S, Ducimetière P, Cottel D, Montaye M, Amouyel P, Brousseau T
Clin Biochem. 2009
PubMed ID: 19303401
Hepatitis C virus targets over-expression of arginase I in hepatocarcinogenesis.
Cao W, Sun B, Feitelson MA, Wu T, Tur-Kaspa R, Fan Q
Int J Cancer. 2009
PubMed ID: 19253371
Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma.
North ML, Khanna N, Marsden PA, Grasemann H, Scott JA
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19286931
Arginase activity in carcinoma of the gallbladder: a pilot study.
Shukla VK, Tandon A, Ratha BK, Sharma D, Singh TB, Basu S
Eur J Cancer Prev. 2009
PubMed ID: 19282757
Tumor-educated CD11bhighIalow regulatory dendritic cells suppress T cell response through arginase I.
Liu Q, Zhang C, Sun A, Zheng Y, Wang L, Cao X
J Immunol. 2009
PubMed ID: 19414774
Characterization of a preclinical model of chronic ischemic wound.
Roy S, Biswas S, Khanna S, Gordillo G, Bergdall V, Green J, Marsh CB, Gould LJ, Sen CK
Physiol Genomics. 2009
PubMed ID: 19293328
Regulation of arginase I activity and expression by both PD-1 and CTLA-4 on the myeloid-derived suppressor cells.
Liu Y, Yu Y, Yang S, Zeng B, Zhang Z, Jiao G, Zhang Y, Cai L, Yang R
Cancer Immunol Immunother. 2009
PubMed ID: 18828017
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis.
Pesce JT, Ramalingam TR, Mentink-Kane MM, Wilson MS, El Kasmi KC, Smith AM, Thompson RW, Cheever AW, Murray PJ, Wynn TA
PLoS Pathog. 2009
PubMed ID: 19360123
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
Arginase promotes neointima formation in rat injured carotid arteries.
Peyton KJ, Ensenat D, Azam MA, Keswani AN, Kannan S, Liu XM, Wang H, Tulis DA, Durante W
Arterioscler Thromb Vasc Biol. 2009
PubMed ID: 19164802
Roles of arginase variants, atopy, and ozone in childhood asthma.
Salam MT, Islam T, Gauderman WJ, Gilliland FD
J Allergy Clin Immunol. 2009
PubMed ID: 19281908
L-arginine as a factor increasing arginase significance in diagnosis of primary and metastatic colorectal cancer.
Graboń W, Mielczarek-Puta M, Chrzanowska A, Barańczyk-Kuźma A
Clin Biochem. 2009
PubMed ID: 19101531
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
Bratt JM, Franzi LM, Linderholm AL, Last MS, Kenyon NJ, Last JA
Toxicol Appl Pharmacol. 2009
PubMed ID: 19027033
Arginase isoenzymes in human cirrhotic liver.
Chrzanowska A, Gajewska B, Barańczyk-Kuźma A
Acta Biochim Pol. 2009
PubMed ID: 19636440
Studies on the functional significance of a C-terminal S-shaped motif in human arginase type I: essentiality for cooperative effects.
García D, Uribe E, Lobos M, Orellana MS, Carvajal N
Arch Biochem Biophys. 2009
PubMed ID: 18957279
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
Scholl-Bürgi S, Sigl SB, Häberle J, Haberlandt E, Rostásy K, Ertl C, Eichinger-Öttl U, Heinz-Erian P, Karall D
J Inherit Metab Dis. 2008
PubMed ID: 19052914
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, Basaraba RJ, König T, Schleicher U, Koo MS, Kaplan G, Fitzgerald KA, Tuomanen EI, Orme IM, Kanneganti TD, Bogdan C, Wynn TA, Murray PJ
Nat Immunol. 2008
PubMed ID: 18978793
Murine ovarian cancer vascular leukocytes require arginase-1 activity for T cell suppression.
Bak SP, Alonso A, Turk MJ, Berwin B
Mol Immunol. 2008
PubMed ID: 18824264
Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism.
Kanda H, Sumi D, Endo A, Toyama T, Chen CL, Kikushima M, Kumagai Y
Arch Toxicol. 2008
PubMed ID: 18488197
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
Litonjua AA, Lasky-Su J, Schneiter K, Tantisira KG, Lazarus R, Klanderman B, Lima JJ, Irvin CG, Peters SP, Hanrahan JP, Liggett SB, Hawkins GA, Meyers DA, Bleecker ER, Lange C, Weiss ST
Am J Respir Crit Care Med. 2008
PubMed ID: 18617639
Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I.
Zakharian TY, Di Costanzo L, Christianson DW
Org Biomol Chem. 2008
PubMed ID: 18802628
Effect of adrenomedullin on hepatic damage in hepatic ischaemia/reperfusion injury in rats.
Kerem M, Bedirli A, Pasaoglu H, Ofluoğlu E, Yilmazer D, Salman B, Yilmaz TU
Liver Int. 2008
PubMed ID: 18435717
Inducible nitric oxide synthase and arginase expression in heart tissue during acute Trypanosoma cruzi infection in mice: arginase I is expressed in infiltrating CD68+ macrophages.
Cuervo H, Pineda MA, Aoki MP, Gea S, Fresno M, Gironès N
J Infect Dis. 2008
PubMed ID: 18473687
Treatment with the arginase inhibitor N(omega)-hydroxy-nor-L-arginine improves vascular function and lowers blood pressure in adult spontaneously hypertensive rat.
Bagnost T, Berthelot A, Bouhaddi M, Laurant P, André C, Guillaume Y, Demougeot C
J Hypertens. 2008
PubMed ID: 18475148
Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.
Gallardo-Soler A, Gómez-Nieto C, Campo ML, Marathe C, Tontonoz P, Castrillo A, Corraliza I
Mol Endocrinol. 2008
PubMed ID: 18323470
Developmental changes in arginase expression and activity in the lung.
Belik J, Shehnaz D, Pan J, Grasemann H
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 18192591
Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.
Deignan JL, Marescau B, Livesay JC, Iyer RK, De Deyn PP, Cederbaum SD, Grody WW
Mol Genet Metab. 2008
PubMed ID: 17997338
Regulation of arginase-1 expression in macrophages by a protein kinase A type I and histone deacetylase dependent pathway.
Haffner I, Teupser D, Holdt LM, Ernst J, Burkhardt R, Thiery J
J Cell Biochem. 2008
PubMed ID: 17577214
Inhibition of NADPH oxidase by apocynin inhibits lipopolysaccharide (LPS) induced up-regulation of arginase in rat alveolar macrophages.
Matthiesen S, Lindemann D, Warnken M, Juergens UR, Racké K
Eur J Pharmacol. 2008
PubMed ID: 18001708
Diabetes-induced coronary vascular dysfunction involves increased arginase activity.
Romero MJ, Platt DH, Tawfik HE, Labazi M, El-Remessy AB, Bartoli M, Caldwell RB, Caldwell RW
Circ Res. 2008
PubMed ID: 17967788
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC Genomics. 2008
PubMed ID: 18973680
Arginine transport is augmented, through modulation of cationic amino acid transporter-1, in obstructive uropathy in rats.
Schwartz IF, Davidovitz A, Chernichovski T, Levin-Iaina N, Guzner-Gur H, Levo Y, Schwartz D
Kidney Blood Press Res. 2008
PubMed ID: 18552509
Age-related alteration of arginase activity impacts on severity of leishmaniasis.
Müller I, Hailu A, Choi BS, Abebe T, Fuentes JM, Munder M, Modolell M, Kropf P
PLoS Negl Trop Dis. 2008
PubMed ID: 18478052
Functional role and species-specific contribution of arginases in pulmonary fibrosis.
Kitowska K, Zakrzewicz D, Königshoff M, Chrobak I, Grimminger F, Seeger W, Bulau P, Eickelberg O
Am J Physiol Lung Cell Mol Physiol. 2008
PubMed ID: 17934065
Contrasting features of urea cycle disorders in human patients and knockout mouse models.
Deignan JL, Cederbaum SD, Grody WW
Mol Genet Metab. 2008
PubMed ID: 17933574
Polyamine homeostasis in arginase knockout mice.
Deignan JL, Livesay JC, Shantz LM, Pegg AE, O'Brien WE, Iyer RK, Cederbaum SD, Grody WW
Am J Physiol Cell Physiol. 2007
PubMed ID: 17686999
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
[Clinical and biochemical alterations in rats treated with high doses of vitamin A].
Alarcón-Corredor OM, Alfonso R
Arch Latinoam Nutr. 2007
PubMed ID: 18271400
Expression, purification, assay, and crystal structure of perdeuterated human arginase I.
Di Costanzo L, Moulin M, Haertlein M, Meilleur F, Christianson DW
Arch Biochem Biophys. 2007
PubMed ID: 17562323
MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.
Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y
Am J Physiol Cell Physiol. 2007
PubMed ID: 17442735
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.
Dumont J, Zureik M, Cottel D, Montaye M, Ducimetière P, Amouyel P, Brousseau T
J Med Genet. 2007
PubMed ID: 17369504
Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans.
Holowatz LA, Kenney WL
J Physiol. 2007
PubMed ID: 17347269
Oxidative-nitrosative stress and post-translational protein modifications: implications to lung structure-function relations. Arginase modulates NF-kappaB activity via a nitric oxide-dependent mechanism.
Ckless K, van der Vliet A, Janssen-Heininger Y
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17218616
The combination of peripheral nerve grafts and acidic fibroblast growth factor enhances arginase I and polyamine spermine expression in transected rat spinal cords.
Kuo HS, Tsai MJ, Huang MC, Huang WC, Lee MJ, Kuo WC, You LH, Szeto KC, Tsai IL, Chang WC, Chiu CW, Ma H, Chak KF, Cheng H
Biochem Biophys Res Commun. 2007
PubMed ID: 17418108
Crystal structure of human arginase I complexed with thiosemicarbazide reveals an unusual thiocarbonyl mu-sulfide ligand in the binuclear manganese cluster.
Di Costanzo L, Pique ME, Christianson DW
J Am Chem Soc. 2007
PubMed ID: 17469833
Chitin induces accumulation in tissue of innate immune cells associated with allergy.
Reese TA, Liang HE, Tager AM, Luster AD, Van Rooijen N, Voehringer D, Locksley RM
Nature. 2007
PubMed ID: 17450126
Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils.
Jacobsen LC, Theilgaard-Mönch K, Christensen EI, Borregaard N
Blood. 2007
PubMed ID: 17119118
Time course of vascular arginase expression and activity in spontaneously hypertensive rats.
Demougeot C, Prigent-Tessier A, Bagnost T, André C, Guillaume Y, Bouhaddi M, Marie C, Berthelot A
Life Sci. 2007
PubMed ID: 17223136
Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).
Reid KM, Tsung A, Kaizu T, Jeyabalan G, Ikeda A, Shao L, Wu G, Murase N, Geller DA
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17023552
Identification of arginase in human placental villi.
Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T
Placenta. 2007
PubMed ID: 16720041
Large-scale phosphorylation analysis of mouse liver.
Villén J, Beausoleil SA, Gerber SA, Gygi SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242355
Cell- and isoform-specific increases in arginase expression in acute silica-induced pulmonary inflammation.
Poljakovic M, Porter DW, Millecchia L, Kepka-Lenhart D, Beighley C, Wolfarth MG, Castranova V, Morris SM
J Toxicol Environ Health A. 2007
PubMed ID: 17365572
Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma.
Ochoa AC, Zea AH, Hernandez C, Rodriguez PC
Clin Cancer Res. 2007
PubMed ID: 17255300
A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE).
Hou J, Charters AM, Lee SC, Zhao Y, Wu MK, Jones SJ, Marra MA, Hoodless PA
BMC Dev Biol. 2007
PubMed ID: 17683524
Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion.
Cheng PN, Lam TL, Lam WM, Tsui SM, Cheng AW, Lo WH, Leung YC
Cancer Res. 2007
PubMed ID: 17210712
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Advantage of serum type-I arginase and ornithine carbamoyltransferase in the evaluation of acute and chronic liver damage induced by thioacetamide in rats.
Murayama H, Ikemoto M, Fukuda Y, Tsunekawa S, Nagata A
Clin Chim Acta. 2007
PubMed ID: 16872590
Arginase-flotillin interaction brings arginase to red blood cell membrane.
Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z
FEBS Lett. 2006
PubMed ID: 17113085
Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function.
Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, Dolcetti L, Bronte V, Borrello I
J Exp Med. 2006
PubMed ID: 17101732
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmmermann N, Mahalingam S, Webb DC, Tremethick DJ, Thompson PJ, Hogan SP, Rothenberg ME, Cowden WB, Foster PS
J Immunol. 2006
PubMed ID: 17015747
Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis.
Mora AL, Torres-González E, Rojas M, Corredor C, Ritzenthaler J, Xu J, Roman J, Brigham K, Stecenko A
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16709958
Loss of arginase I results in increased proliferation of neural stem cells.
Becker-Catania SG, Gregory TL, Yang Y, Gau CL, de Vellis J, Cederbaum SD, Iyer RK
J Neurosci Res. 2006
PubMed ID: 16773651
Ornithine deficiency in the arginase double knockout mouse.
Deignan JL, Livesay JC, Yoo PK, Goodman SI, O'Brien WE, Iyer RK, Cederbaum SD, Grody WW
Mol Genet Metab. 2006
PubMed ID: 16753325
Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons.
Estévez AG, Sahawneh MA, Lange PS, Bae N, Egea M, Ratan RR
J Neurosci. 2006
PubMed ID: 16914676
Involvement of arginase in regulating myometrial contractions during gestation in the rat.
Hirata M, Obayashi S, Sakamoto S, Aso T, Imamura M, Azuma H
Mol Hum Reprod. 2006
PubMed ID: 16735458
Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity, and L-arginine metabolism.
Holán V, Pindjáková J, Krulová M, Neuwirth A, Fric J, Zajícová A
Transplantation. 2006
PubMed ID: 16794538
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
CD11b+/Gr-1+ myeloid suppressor cells cause T cell dysfunction after traumatic stress.
Makarenkova VP, Bansal V, Matta BM, Perez LA, Ochoa JB
J Immunol. 2006
PubMed ID: 16455964
Inhibition of rat liver and kidney arginase by cadmium ion.
Tormanen CD
J Enzyme Inhib Med Chem. 2006
PubMed ID: 16570515
Spermine increases arginase activity in the liver after carbon tetrachloride-induced hepatic injury in Long-Evans rats.
Méndez JD, De Haro Hernández R, Conejo VA
Biomed Pharmacother. 2006
PubMed ID: 16459053
Knockdown of arginase I restores NO signaling in the vasculature of old rats.
White AR, Ryoo S, Li D, Champion HC, Steppan J, Wang D, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE
Hypertension. 2006
PubMed ID: 16380531
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
Li H, Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Estela Del Rio-Navarro B, Kistner EO, Gjessing HK, Lara-Sanchez Idel C, Chiu GY, London SJ
J Allergy Clin Immunol. 2006
PubMed ID: 16387594
Probing the role of the hyper-reactive histidine residue of arginase.
Colleluori DM, Reczkowski RS, Emig FA, Cama E, Cox JD, Scolnick LR, Compher K, Jude K, Han S, Viola RE, Christianson DW, Ash DE
Arch Biochem Biophys. 2005
PubMed ID: 16266687
Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma.
Rodriguez PC, Hernandez CP, Quiceno D, Dubinett SM, Zabaleta J, Ochoa JB, Gilbert J, Ochoa AC
J Exp Med. 2005
PubMed ID: 16186186
Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.
Di Costanzo L, Sabio G, Mora A, Rodriguez PC, Ochoa AC, Centeno F, Christianson DW
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16141327
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Arginase I induction during Leishmania major infection mediates the development of disease.
Iniesta V, Carcelén J, Molano I, Peixoto PM, Redondo E, Parra P, Mangas M, Monroy I, Campo ML, Nieto CG, Corraliza I
Infect Immun. 2005
PubMed ID: 16113329
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, Hazen SL, Vichinsky EP, Morris SM, Gladwin MT
JAMA. 2005
PubMed ID: 15998894
Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta.
Gray MJ, Poljakovic M, Kepka-Lenhart D, Morris SM
Gene. 2005
PubMed ID: 15922518
The activity of ornithine transcarbamoylase and arginase during mechanical jaundice in the rat model.
Beck B, Ciszek M, Polaniak R, Beyga Z, Król W, Drozdz M, Shani J
J Surg Res. 2005
PubMed ID: 15916970
Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway.
Liu H, Drew P, Gaugler AC, Cheng Y, Visner GA
Am J Transplant. 2005
PubMed ID: 15888029
Macrophage arginase regulation by CCAAT/enhancer-binding protein beta.
Albina JE, Mahoney EJ, Daley JM, Wesche DE, Morris SM, Reichner JS
Shock. 2005
PubMed ID: 15665733
Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta.
Ensunsa JL, Symons JD, Lanoue L, Schrader HR, Keen CL
Exp Biol Med (Maywood). 2004
PubMed ID: 15564441
Effects of N-acetylcysteine on arginase, ornithine and nitric oxide in renal ischemia-reperfusion injury.
Erbas H, Aydogdu N, Kaymak K
Pharmacol Res. 2004
PubMed ID: 15458774
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Design of amino acid aldehydes as transition-state analogue inhibitors of arginase.
Shin H, Cama E, Christianson DW
J Am Chem Soc. 2004
PubMed ID: 15315440
Protective role of arginase in a mouse model of colitis.
Gobert AP, Cheng Y, Akhtar M, Mersey BD, Blumberg DR, Cross RK, Chaturvedi R, Drachenberg CB, Boucher JL, Hacker A, Casero RA, Wilson KT
J Immunol. 2004
PubMed ID: 15265947
Inhibitor coordination interactions in the binuclear manganese cluster of arginase.
Cama E, Pethe S, Boucher JL, Han S, Emig FA, Ash DE, Viola RE, Mansuy D, Christianson DW
Biochemistry. 2004
PubMed ID: 15248756
Enhancer-mediated control of macrophage-specific arginase I expression.
Pauleau AL, Rutschman R, Lang R, Pernis A, Watowich SS, Murray PJ
J Immunol. 2004
PubMed ID: 15187136
Mouse strain susceptibility to trypanosome infection: an arginase-dependent effect.
Duleu S, Vincendeau P, Courtois P, Semballa S, Lagroye I, Daulouède S, Boucher JL, Wilson KT, Veyret B, Gobert AP
J Immunol. 2004
PubMed ID: 15128819
Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex.
Liu P, Smith PF, Appleton I, Darlington CL, Bilkey DK
Neurobiol Aging. 2004
PubMed ID: 15013576
Nitric oxide synthase and arginase expression changes in the rat perirhinal and entorhinal cortices following unilateral vestibular damage: a link to deficits in object recognition?
Liu P, Gliddon CM, Lindsay L, Darlington CL, Smith PF
J Vestib Res. 2004
PubMed ID: 15735325
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Expression and activity of arginase isoenzymes during normal and diabetes-impaired skin repair.
Kämpfer H, Pfeilschifter J, Frank S
J Invest Dermatol. 2003
PubMed ID: 14675208
Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid.
Erişir M, Beytut E, Ozan S, Aksakal M
Cell Biochem Funct. 2003
PubMed ID: 14624471
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Induction of arginase I and II in bleomycin-induced fibrosis of mouse lung.
Endo M, Oyadomari S, Terasaki Y, Takeya M, Suga M, Mori M, Gotoh T
Am J Physiol Lung Cell Mol Physiol. 2003
PubMed ID: 12679322
Structural and functional importance of first-shell metal ligands in the binuclear manganese cluster of arginase I.
Cama E, Emig FA, Ash DE, Christianson DW
Biochemistry. 2003
PubMed ID: 12820884
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, Muntel EE, Witte DP, Pegg AA, Foster PS, Hamid Q, Rothenberg ME
J Clin Invest. 2003
PubMed ID: 12813022
Arginase acts as an alternative pathway of L-arginine metabolism in experimental colon anastomosis.
Witte MB, Vogt N, Stuelten C, Gotoh T, Mori M, Becker HD
J Gastrointest Surg. 2003
PubMed ID: 12654563
IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice.
Bronte V, Serafini P, De Santo C, Marigo I, Tosello V, Mazzoni A, Segal DM, Staib C, Lowel M, Sutter G, Colombo MP, Zanovello P
J Immunol. 2003
PubMed ID: 12496409
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Coinduction of nitric oxide synthase and arginine metabolic enzymes in endotoxin-induced uveitis rats.
Koga T, Koshiyama Y, Gotoh T, Yonemura N, Hirata A, Tanihara H, Negi A, Mori M
Exp Eye Res. 2002
PubMed ID: 12470967
L-Arginine transport is augmented through up-regulation of tubular CAT-2 mRNA in ischemic acute renal failure in rats.
Schwartz IF, Schwartz D, Traskonov M, Chernichovsky T, Wollman Y, Gnessin E, Topilsky I, Levo Y, Iaina A
Kidney Int. 2002
PubMed ID: 12371970
Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro.
Cai D, Deng K, Mellado W, Lee J, Ratan RR, Filbin MT
Neuron. 2002
PubMed ID: 12194870
Insights into the interaction of human liver arginase with tightly and weakly bound manganese ions by chemical modification and site-directed mutagenesis studies.
Orellana MS, López V, Uribe E, Fuentes M, Salas M, Carvajal N
Arch Biochem Biophys. 2002
PubMed ID: 12139964
Overexpression of arginase I in enterocytes of transgenic mice elicits a selective arginine deficiency and affects skin, muscle, and lymphoid development.
de Jonge WJ, Hallemeesch MM, Kwikkers KL, Ruijter JM, de Gier-de Vries C, van Roon MA, Meijer AJ, Marescau B, de Deyn PP, Deutz NE, Lamers WH
Am J Clin Nutr. 2002
PubMed ID: 12081826
Mouse model for human arginase deficiency.
Iyer RK, Yoo PK, Kern RM, Rozengurt N, Tsoa R, O'Brien WE, Yu H, Grody WW, Cederbaum SD
Mol Cell Biol. 2002
PubMed ID: 12052859
Arginase expression in mouse embryonic development.
Yu H, Iyer RK, Yoo PK, Kern RM, Grody WW, Cederbaum SD
Mech Dev. 2002
PubMed ID: 12049781
Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma.
Porembska Z, Skwarek A, Mielczarek M, Barańczyk-Kuźma A
Cancer. 2002
PubMed ID: 12115381
Expression of the liver form of arginase in erythrocytes.
Kim PS, Iyer RK, Lu KV, Yu H, Karimi A, Kern RM, Tai DK, Cederbaum SD, Grody WW
Mol Genet Metab. 2002
PubMed ID: 12083807
Upregulation of arginase expression in wound-derived fibroblasts.
Witte MB, Barbul A, Schick MA, Vogt N, Becker HD
J Surg Res. 2002
PubMed ID: 12069499
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
Español A, Eiján AM, Mazzoni E, Davel L, Jasnis MA, Sacerdote De Lustig E, Sales ME
Int J Mol Med. 2002
PubMed ID: 12011984
Synthesis and evaluation of alternative substrates for arginase.
Han S, Moore RA, Viola RE
Bioorg Chem. 2002
PubMed ID: 12020133
Induction of arginase II in livers of bile duct-ligated rats.
Wei CL, Hon WM, Lee KH, Mori M, Gotoh T, Khoo HE
Biochem Pharmacol. 2002
PubMed ID: 11931836
Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.
Iniesta V, Gómez-Nieto LC, Molano I, Mohedano A, Carcelén J, Mirón C, Alonso C, Corraliza I
Parasite Immunol. 2002
PubMed ID: 11982856
Functional consequences of the G235R mutation in liver arginase leading to hyperargininemia.
Lavulo LT, Emig FA, Ash DE
Arch Biochem Biophys. 2002
PubMed ID: 11883902
Arginase in glomerulonephritis.
Waddington SN
Kidney Int. 2002
PubMed ID: 11849441
Effects of arginase isoforms on NO Production by nNOS.
Que LG, George SE, Gotoh T, Mori M, Huang YC
Nitric Oxide. 2002
PubMed ID: 11829529
Anti-CYP2D6 antibodies detected by quantitative radioligand assay and relation to antibodies to liver-specific arginase in patients with autoimmune hepatitis.
Kimura M, Tatsumi KI, Tada H, Izumi Y, Kaneko A, Kato M, Masuzawa M, Ikemoto M, Yabusaki Y, Hidaka Y, Amino N
Clin Chim Acta. 2002
PubMed ID: 11750286
Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.
Tygstrup N, Bangert K, Ott P, Bisgaard HC
Biochem Biophys Res Commun. 2002
PubMed ID: 11779202
Activities of arginase I and II are limiting for endothelial cell proliferation.
Li H, Meininger CJ, Kelly KA, Hawker JR, Morris SM, Wu G
Am J Physiol Regul Integr Comp Physiol. 2002
PubMed ID: 11742824
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism.
Hesse M, Modolell M, La Flamme AC, Schito M, Fuentes JM, Cheever AW, Pearce EJ, Wynn TA
J Immunol. 2001
PubMed ID: 11714822
Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M
Nat Biotechnol. 2001
PubMed ID: 11329013
Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.
Lavulo LT, Sossong TM, Brigham-Burke MR, Doyle ML, Cox JD, Christianson DW, Ash DE
J Biol Chem. 2001
PubMed ID: 11278703
Glucocorticoids inhibit lipopolysaccharide-induced up-regulation of arginase in rat alveolar macrophages.
Klasen S, Hammermann R, Fuhrmann M, Lindemann D, Beck KF, Pfeilschifter J, Racké K
Br J Pharmacol. 2001
PubMed ID: 11250887
Arginase I expression and activity in human mononuclear cells after injury.
Ochoa JB, Bernard AC, O'Brien WE, Griffen MM, Maley ME, Rockich AK, Tsuei BJ, Boulanger BR, Kearney PA, Morris Jr SM
Ann Surg. 2001
PubMed ID: 11224628
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
[Influence of alimentary zinc deficiency on nitrogen elimination and enzyme activities of the urea cycle].
Roth VH
J Anim Physiol Anim Nutr (Berl). 2001
PubMed ID: 11686772
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells.
Li H, Meininger CJ, Hawker JR, Haynes TE, Kepka-Lenhart D, Mistry SK, Morris SM, Wu G
Am J Physiol Endocrinol Metab. 2001
PubMed ID: 11120661
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos.
Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044609
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Regulation of genes for inducible nitric oxide synthase and urea cycle enzymes in rat liver in endotoxin shock.
Tabuchi S, Gotoh T, Miyanaka K, Tomita K, Mori M
Biochem Biophys Res Commun. 2000
PubMed ID: 10652239
Arginase-boronic acid complex highlights a physiological role in erectile function.
Cox JD, Kim NN, Traish AM, Christianson DW
Nat Struct Biol. 1999
PubMed ID: 10542097
Identification of a novel R21X mutation in the liver-type arginase gene (ARG1) in four Portuguese patients with argininemia.
Cardoso ML, Martins E, Vasconcelos R, Vilarinho L, Rocha J
Hum Mutat. 1999
PubMed ID: 10502833
Regulation of arginase isoforms I and II by IL-4 in cultured murine peritoneal macrophages.
Louis CA, Mody V, Henry WL, Reichner JS, Albina JE
Am J Physiol. 1999
PubMed ID: 9887201
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Induction of arginase isoforms in the lung during hyperoxia.
Que LG, Kantrow SP, Jenkinson CP, Piantadosi CA, Huang YC
Am J Physiol. 1998
PubMed ID: 9688940
Effects of growth hormone on steroid-induced increase in ability of urea synthesis and urea enzyme mRNA levels.
Grøfte T, Jensen DS, Grønbaek H, Wolthers T, Jensen SA, Tygstrup N, Vilstrup H
Am J Physiol. 1998
PubMed ID: 9688877
Cloning and characterization of the mouse and rat type II arginase genes.
Iyer RK, Bando JM, Jenkinson CP, Vockley JG, Kim PS, Kern RM, Cederbaum SD, Grody WW
Mol Genet Metab. 1998
PubMed ID: 9608538
The human arginases and arginase deficiency.
Iyer R, Jenkinson CP, Vockley JG, Kern RM, Grody WW, Cederbaum S
J Inherit Metab Dis. 1998
PubMed ID: 9686347
Regulation of the urea cycle enzyme genes in nitric oxide synthesis.
Mori M, Gotoh T, Nagasaki A, Takiguchi M, Sonoki T
J Inherit Metab Dis. 1998
PubMed ID: 9686345
Ethanol-induced intracellular calcium mobilization rapidly alters gene expression in the mouse blastocyst.
Rout UK, Krawetz SA, Armant DR
Cell Calcium. 1997
PubMed ID: 9502196
Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
Scolnick LR, Kanyo ZF, Cavalli RC, Ash DE, Christianson DW
Biochemistry. 1997
PubMed ID: 9265637
Inhibition of arginase in rat and rabbit alveolar macrophages by N omega-hydroxy-D,L-indospicine, effects on L-arginine utilization by nitric oxide synthase.
Hey C, Boucher JL, Vadon-Le Goff S, Ketterer G, Wessler I, Racké K
Br J Pharmacol. 1997
PubMed ID: 9179379
Molecular cloning and sequence analysis of the cDNA for the mouse counterpart to adult hamster liver purified growth inhibitory factor.
Hashimoto C, Masuda H, Ayaki M, Suzuki Y, Uenaka A, Seya T, Miyoshi J, Takahashi K, Inui Y
Biochim Biophys Acta. 1997
PubMed ID: 9060991
Coinduction of nitric-oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide.
Sonoki T, Nagasaki A, Gotoh T, Takiguchi M, Takeya M, Matsuzaki H, Mori M
J Biol Chem. 1997
PubMed ID: 9013624
Structure of a unique binuclear manganese cluster in arginase.
Kanyo ZF, Scolnick LR, Ash DE, Christianson DW
Nature. 1996
PubMed ID: 8849731
Development of the ornithine cycle in rat liver: zonation of a metabolic pathway.
Dingemanse MA, De Jonge WJ, De Boer PA, Mori M, Lamers WH, Moorman AF
Hepatology. 1996
PubMed ID: 8690412
Molecular basis of phenotypic variation in patients with argininemia.
Uchino T, Snyderman SE, Lambert M, Qureshi IA, Shapira SK, Sansaricq C, Smit LM, Jakobs C, Matsuda I
Hum Genet. 1995
PubMed ID: 7649538
Coordinate induction of the urea cycle enzymes by glucagon and dexamethasone is accomplished by three different mechanisms.
Ulbright C, Snodgrass PJ
Arch Biochem Biophys. 1993
PubMed ID: 8460937
Three novel mutations in the liver-type arginase gene in three unrelated Japanese patients with argininemia.
Uchino T, Haraguchi Y, Aparicio JM, Mizutani N, Higashikawa M, Naitoh H, Mori M, Matsuda I
Am J Hum Genet. 1992
PubMed ID: 1463019
Molecular genetic study of human arginase deficiency.
Grody WW, Klein D, Dodson AE, Kern RM, Wissmann PB, Goodman BK, Bassand P, Marescau B, Kang SS, Leonard JV
Am J Hum Genet. 1992
PubMed ID: 1598908
Crystallization and oligomeric structure of rat liver arginase.
Kanyo ZF, Chen CY, Daghigh F, Ash DE, Christianson DW
J Mol Biol. 1992
PubMed ID: 1569574
In vitro analysis of the rat liver-type arginase promoter.
Takiguchi M, Mori M
J Biol Chem. 1991
PubMed ID: 2026618
Expression of human liver arginase in Escherichia coli. Purification and properties of the product.
Ikemoto M, Tabata M, Miyake T, Kono T, Mori M, Totani M, Murachi T
Biochem J. 1990
PubMed ID: 2241902
Molecular basis of argininemia. Identification of two discrete frame-shift deletions in the liver-type arginase gene.
Haraguchi Y, Aparicio JM, Takiguchi M, Akaboshi I, Yoshino M, Mori M, Matsuda I
J Clin Invest. 1990
PubMed ID: 2365823
Differential expression of the two human arginase genes in hyperargininemia. Enzymatic, pathologic, and molecular analysis.
Grody WW, Argyle C, Kern RM, Dizikes GJ, Spector EB, Strickland AD, Klein D, Cederbaum SD
J Clin Invest. 1989
PubMed ID: 2913054
Human liver-type arginase gene: structure of the gene and analysis of the promoter region.
Takiguchi M, Haraguchi Y, Mori M
Nucleic Acids Res. 1988
PubMed ID: 3174433
Structural organization of the gene for rat liver-type arginase.
Ohtake A, Takiguchi M, Shigeto Y, Amaya Y, Kawamoto S, Mori M
J Biol Chem. 1988
PubMed ID: 2892837
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression.
Shapiro MB, Senapathy P
Nucleic Acids Res. 1987
PubMed ID: 3658675
Ornithine transcarbamylase deficiency in spf and spf-ash mice: genes, mRNAs and mRNA precursors.
Ohtake A, Takayanagi M, Yamamoto S, Nakajima H, Mori M
Biochem Biophys Res Commun. 1987
PubMed ID: 3039990
Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver arginase.
Kawamoto S, Amaya Y, Murakami K, Tokunaga F, Iwanaga S, Kobayashi K, Saheki T, Kimura S, Mori M
J Biol Chem. 1987
PubMed ID: 3571256
Molecular cloning and nucleotide sequence of cDNA for human liver arginase.
Haraguchi Y, Takiguchi M, Amaya Y, Kawamoto S, Matsuda I, Mori M
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3540966
The gene for human liver arginase (ARG1) is assigned to chromosome band 6q23.
Sparkes RS, Dizikes GJ, Klisak I, Grody WW, Mohandas T, Heinzmann C, Zollman S, Lusis AJ, Cederbaum SD
Am J Hum Genet. 1986
PubMed ID: 3752085
Decreased urea synthesis in cafeteria-diet-induced obesity in the rat.
Barber T, Viña JR, Viña J, Cabo J
Biochem J. 1985
PubMed ID: 4062872
The publication is not currently in our database, click on the link below to see it on pubmed.
PubMed ID:

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	383	11846	29221
EnsEMBL Gene(s)	ENSG00000118520	ENSMUSG00000019987	ENSRNOG00000013304
Unigene	Hs.440934	Mm.154144	Rn.9857
Homologene	ARG1	Arg1	Arg1
OMIM	608313	N/A	N/A
GeneCards	ARG1	N/A	N/A
Beta Cell Genomics	DT.115141 DT.95173777 DT.95173781	DT.101407775 DT.536348	N/A
Reactome	P05089	N/A	N/A
Plasma Peptide Atlas	ENSP00000349446	N/A	N/A
WikiGenes	383	11846	29221

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
ARG1	FLOT1	HPRD, MINT	empirical	17113085
ARG1	GABARAP	IntAct	empirical	20562859
ARG1	GABARAPL2	IntAct	empirical	20562859
ARG1	EIF5A	Sanger Interaction Map	predicted	15345047
ARG1	ESR1	IntAct	empirical	21182205 21182203
ARG1	KPNA6	Sanger Interaction Map	predicted	15345047
ARG1	HAGH	Sanger Interaction Map	predicted	15345047
ARG1	ARG2	HPRD	empirical	11849441
ARG1	MYC	IntAct	empirical	21150319
ARG1	NOS1	HPRD	empirical	11849441
ARG1	UCHL5	BioGRID	empirical	21800051
ARG1	USP53	IntAct, BioGRID	empirical	19615732
ARG1	C12orf44	IntAct, BioGRID	empirical	20562859
ARG1	SLC2A4	IntAct	empirical	16396496
ARG1	UBC	BioGRID	empirical	22118674 21139048
ARG1	ALDH4A1	IntAct	empirical	21988832