Home KLRD1
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(Human) GRCh37 - chr12:10378657..10469850 (91.19 kb) View in Genome Browser
(Mouse) NCBIM37 - chr6:129541800..129548793 (6.99 kb) View in Genome Browser
(Rat) RGSC3.4 - chr4:166867721..166879170 (11.45 kb) View in Genome Browser
HaemAtlas Expression Table for KLRD1:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for KLRD1:The KLRD1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| KLRD1 | HLA-B | HPRD | empirical | 8046333 |
| KLRD1 | HLA-E | HPRD, BioGRID | empirical | 14734748 9815261 9486650 9886400 |
| KLRD1 | HLA-G | HPRD | empirical | 9405670 |
| KLRD1 | KLRC1 | HPRD, BioGRID, Reactome | empirical | 8943374 9034158 9485206 10320637 11513152 |
| KLRD1 | KLRC2 | HPRD, BioGRID | empirical | 10320637 8943374 |
| KLRD1 | KLRC3 | HPRD, BioGRID | empirical | 8943374 10201920 |
| KLRD1 | KLRD1 | HPRD | empirical | 10023772 |
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Publications: 103
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Rat and mouse CD94 associate directly with the activating transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell cytotoxicity.
Saether PC, Hoelsbrekken SE, Fossum S, Dissen E
J Immunol. 2011
PubMed ID: 22084441
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Calcineurin-dependent negative regulation of CD94/NKG2A expression on naive CD8+ T cells.
Cho JH, Kim HO, Webster K, Palendira M, Hahm B, Kim KS, King C, Tangye SG, Sprent J
Blood. 2011
PubMed ID: 21540458
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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CD94 is essential for NK cell-mediated resistance to a lethal viral disease.
Fang M, Orr MT, Spee P, Egebjerg T, Lanier LL, Sigal LJ
Immunity. 2011
PubMed ID: 21439856
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Binding affinities of NKG2D and CD94 to sialyl Lewis X-expressing N-glycans and heparin.
Higai K, Suzuki C, Imaizumi Y, Xin X, Azuma Y, Matsumoto K
Biol Pharm Bull. 2011
PubMed ID: 21212510
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Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population.
Ma J, Guo X, Wu X, Li J, Zhu X, Li Z, Li J, Pan L, Li T, Li H, Liu Y
J Med Virol. 2010
PubMed ID: 20648603
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[Study on expression of natural killer (NK) cell C-type lectin-like receptors in nasal NK/T-cell lymphomas].
Nong L, Zhang S, Li Y, Zhang Y, Wang Y, Li T
Zhonghua Bing Li Xue Za Zhi. 2010
PubMed ID: 20654155
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis.
Morel E, Escamochero S, Cabañas R, Díaz R, Fiandor A, Bellón T
J Allergy Clin Immunol. 2010
PubMed ID: 20132973
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CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets.
Yu J, Mao HC, Wei M, Hughes T, Zhang J, Park IK, Liu S, McClory S, Marcucci G, Trotta R, Caligiuri MA
Blood. 2010
PubMed ID: 19897577
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Development and function of CD94-deficient natural killer cells.
Orr MT, Wu J, Fang M, Sigal LJ, Spee P, Egebjerg T, Dissen E, Fossum S, Phillips JH, Lanier LL
PLoS One. 2010
PubMed ID: 21151939
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Short-term exposure to human cytomegalovirus-infected fibroblasts induces a proportional increase of active CD94/NKG2A(+) natural killer cells.
Petersen L, Petersen CC, Møller-Larsen A, Hokland ME
Hum Immunol. 2010
PubMed ID: 19782712
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A high dose of intravenous immunoglobulin increases CD94 expression on natural killer cells in women with recurrent spontaneous abortion.
Shimada S, Takeda M, Nishihira J, Kaneuchi M, Sakuragi N, Minakami H, Yamada H
Am J Reprod Immunol. 2009
PubMed ID: 19811464
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CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
Yu J, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM, Caligiuri MA
J Immunol. 2009
PubMed ID: 19801519
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NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.
Higai K, Imaizumi Y, Suzuki C, Azuma Y, Matsumoto K
Biochem Biophys Res Commun. 2009
PubMed ID: 19555665
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NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid.
Imaizumi Y, Higai K, Suzuki C, Azuma Y, Matsumoto K
Biochem Biophys Res Commun. 2009
PubMed ID: 19303396
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.
Sáez-Borderías A, Romo N, Magri G, Gumá M, Angulo A, López-Botet M
J Immunol. 2009
PubMed ID: 19124726
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Association between high expression of natural killer related-genes (NCAM/CD94) and early death during induction in children with acute myeloid leukemia.
Lonigro L, Mirabile E, Munda S, Barchitta M, Bottino D, Fazzio A, Di Cataldo A, Agodi A, Schilirò G
Leukemia. 2008
PubMed ID: 18323797
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Restricted expression of C-type lectin-like natural killer receptors by CD8 T cells in the murine small intestine.
Jänner N, Hahnke K, Mollenkopf HJ, Steinhoff U, Kaufmann SH, Mittrücker HW
Immunology. 2008
PubMed ID: 18298548
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Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.
Kim S, Lalani S, Parekh VV, Vincent TL, Wu L, Van Kaer L
J Clin Invest. 2008
PubMed ID: 18451996
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Uncommon endocytic and trafficking pathway of the natural killer cell CD94/NKG2A inhibitory receptor.
Masilamani M, Narayanan S, Prieto M, Borrego F, Coligan JE
Traffic. 2008
PubMed ID: 18363778
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Structural basis for NKG2A/CD94 recognition of HLA-E.
Kaiser BK, Pizarro JC, Kerns J, Strong RK
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18448674
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Increased frequency of human leukocyte antigen-E inhibitory receptor CD94/NKG2A-expressing peritoneal natural killer cells in patients with endometriosis.
Galandrini R, Porpora MG, Stoppacciaro A, Micucci F, Capuano C, Tassi I, Di Felice A, Benedetti-Panici P, Santoni A
Fertil Steril. 2008
PubMed ID: 17706207
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CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
Petrie EJ, Clements CS, Lin J, Sullivan LC, Johnson D, Huyton T, Heroux A, Hoare HL, Beddoe T, Reid HH, Wilce MC, Brooks AG, Rossjohn J
J Exp Med. 2008
PubMed ID: 18332182
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Cutting edge: engagement of NKG2A on CD8+ effector T cells limits immunopathology in influenza pneumonia.
Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI
J Immunol. 2008
PubMed ID: 18096998
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The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.
Sullivan LC, Clements CS, Beddoe T, Johnson D, Hoare HL, Lin J, Huyton T, Hopkins EJ, Reid HH, Wilce MC, Kabat J, Borrego F, Coligan JE, Rossjohn J, Brooks AG
Immunity. 2007
PubMed ID: 18083576
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High expression of NKG2A/CD94 and low expression of granzyme B are associated with reduced cord blood NK cell activity.
Wang Y, Xu H, Zheng X, Wei H, Sun R, Tian Z
Cell Mol Immunol. 2007
PubMed ID: 17976318
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Qa-1(b)-dependent modulation of dendritic cell and NK cell cross-talk in vivo.
Colmenero P, Zhang AL, Qian T, Lu L, Cantor H, Söderström K, Engleman EG
J Immunol. 2007
PubMed ID: 17878358
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Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease.
Seo J, Park JS, Nam JH, Bang D, Sohn S, Lee ES, Park KS
Tissue Antigens. 2007
PubMed ID: 17767552
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Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY
Immunity. 2006
PubMed ID: 16973387
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CD94/NKG2A expression is associated with proliferative potential of CD8 T cells during persistent polyoma virus infection.
Byers AM, Andrews NP, Lukacher AE
J Immunol. 2006
PubMed ID: 16670321
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The finished DNA sequence of human chromosome 12.
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G, Gibbs RA, Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
Nature. 2006
PubMed ID: 16541075
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The human CD94 gene encodes multiple, expressible transcripts including a new partner of NKG2A/B.
Lieto LD, Maasho K, West D, Borrego F, Coligan JE
Genes Immun. 2006
PubMed ID: 16237464
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The immunosuppressive agent FK506 enhances the cytolytic activity of inhibitory natural killer cell receptor (CD94/NKG2A)-expressing CD8 T cells.
Tanaka J, Toubai T, Iwao N, Tsutsumi Y, Kato N, Miura Y, Shigematsu A, Hirate D, Ota S, Asaka M, Imamura M
Transplantation. 2005
PubMed ID: 16378079
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression.
Stevenaert F, Van Beneden K, De Colvenaer V, Franki AS, Debacker V, Boterberg T, Deforce D, Pfeffer K, Plum J, Elewaut D, Leclercq G
Blood. 2005
PubMed ID: 15827137
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The CD94/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells.
Gumá M, Busch LK, Salazar-Fontana LI, Bellosillo B, Morte C, García P, López-Botet M
Eur J Immunol. 2005
PubMed ID: 15940674
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IFN-gamma-mediated negative feedback regulation of NKT-cell function by CD94/NKG2.
Ota T, Takeda K, Akiba H, Hayakawa Y, Ogasawara K, Ikarashi Y, Miyake S, Wakasugi H, Yamamura T, Kronenberg M, Raulet DH, Kinoshita K, Yagita H, Smyth MJ, Okumura K
Blood. 2005
PubMed ID: 15746081
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The role of TCR stimulation and TGF-beta in controlling the expression of CD94/NKG2A receptors on CD8 T cells.
Gunturi A, Berg RE, Crossley E, Murray S, Forman J
Eur J Immunol. 2005
PubMed ID: 15714583
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Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection.
Jinushi M, Takehara T, Tatsumi T, Kanto T, Miyagi T, Suzuki T, Kanazawa Y, Hiramatsu N, Hayashi N
J Immunol. 2004
PubMed ID: 15528343
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Differential expression of natural killer cell receptors (CD94/NKG2A) on T cells by the stimulation of G-CSF-mobilized peripheral blood mononuclear cells with anti-CD3 monoclonal antibody and cytokines: a study in stem cell donors.
Tanaka J, Toubai T, Miura Y, Tsutsumi Y, Kato N, Umehara S, Toyoshima N, Ohta S, Asaka M, Imamura M
Transplant Proc. 2004
PubMed ID: 15561299
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
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Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression.
Jones MR, Ravid K
J Biol Chem. 2004
PubMed ID: 14634004
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The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes.
Kambayashi T, Kraft-Leavy JR, Dauner JG, Sullivan BA, Laur O, Jensen PE
J Immunol. 2004
PubMed ID: 14734748
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Bone marrow allograft rejection mediated by a novel murine NK receptor, NKG2I.
Koike J, Wakao H, Ishizuka Y, Sato TA, Hamaoki M, Seino K, Koseki H, Nakayama T, Taniguchi M
J Exp Med. 2004
PubMed ID: 14707119
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Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15.
Lieto LD, Borrego F, You CH, Coligan JE
J Immunol. 2003
PubMed ID: 14607929
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Transcriptional control of murine CD94 gene: differential usage of dual promoters by lymphoid cell types.
Wilhelm BT, Landry JR, Takei F, Mager DL
J Immunol. 2003
PubMed ID: 14530345
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Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs.
Storset AK, Slettedal IO, Williams JL, Law A, Dissen E
Eur J Immunol. 2003
PubMed ID: 12672064
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Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population.
Hikami K, Tsuchiya N, Yabe T, Tokunaga K
Genes Immun. 2003
PubMed ID: 12618865
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Preferential survival of CD8 T and NK cells expressing high levels of CD94.
Gunturi A, Berg RE, Forman J
J Immunol. 2003
PubMed ID: 12574337
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
Michaëlsson J, Teixeira de Matos C, Achour A, Lanier LL, Kärre K, Söderström K
J Exp Med. 2002
PubMed ID: 12461076
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NK cell CD94/NKG2A inhibitory receptors are internalized and recycle independently of inhibitory signaling processes.
Borrego F, Kabat J, Sanni TB, Coligan JE
J Immunol. 2002
PubMed ID: 12444112
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Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction.
Spaggiari GM, Contini P, Dondero A, Carosio R, Puppo F, Indiveri F, Zocchi MR, Poggi A
Blood. 2002
PubMed ID: 12393468
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Cutting edge: CD94/NKG2 is expressed on Th1 but not Th2 cells and costimulates Th1 effector functions.
Meyers JH, Ryu A, Monney L, Nguyen K, Greenfield EA, Freeman GJ, Kuchroo VK
J Immunol. 2002
PubMed ID: 12421909
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TCR specificity dictates CD94/NKG2A expression by human CTL.
Jabri B, Selby JM, Negulescu H, Lee L, Roberts AI, Beavis A, Lopez-Botet M, Ebert EC, Winchester RJ
Immunity. 2002
PubMed ID: 12387742
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Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.
Kabat J, Borrego F, Brooks A, Coligan JE
J Immunol. 2002
PubMed ID: 12165520
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Differential involvement of CD40, CD80, and major histocompatibility complex class I molecules in cytotoxicity induction and interferon-gamma production by human natural killer effectors.
Terrazzano G, Zanzi D, Palomba C, Carbone E, Grimaldi S, Pisanti S, Fontana S, Zappacosta S, Ruggiero G
J Leukoc Biol. 2002
PubMed ID: 12149421
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CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells.
Miller JD, Peters M, Oran AE, Beresford GW, Harrington L, Boss JM, Altman JD
J Immunol. 2002
PubMed ID: 12097371
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Orderly and nonstochastic acquisition of CD94/NKG2 receptors by developing NK cells derived from embryonic stem cells in vitro.
Lian RH, Maeda M, Lohwasser S, Delcommenne M, Nakano T, Vance RE, Raulet DH, Takei F
J Immunol. 2002
PubMed ID: 11994449
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Expression of inhibitory receptors Ly49E and CD94/NKG2 on fetal thymic and adult epidermal TCR V gamma 3 lymphocytes.
Van Beneden K, De Creus A, Stevenaert F, Debacker V, Plum J, Leclercq G
J Immunol. 2002
PubMed ID: 11907085
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NK cells developing in vitro from fetal mouse progenitors express at least one member of the Ly49 family that is acquired in a time-dependent and stochastic manner independently of CD94 and NKG2.
Fraser KP, Gays F, Robinson JH, van Beneden K, Leclercq G, Vance RE, Raulet DH, Brooks CG
Eur J Immunol. 2002
PubMed ID: 11870631
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Implications of CD94 deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
Vance RE, Jamieson AM, Cado D, Raulet DH
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11782535
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Conservation and variation in human and common chimpanzee CD94 and NKG2 genes.
Shum BP, Flodin LR, Muir DG, Rajalingam R, Khakoo SI, Cleland S, Guethlein LA, Uhrberg M, Parham P
J Immunol. 2002
PubMed ID: 11751968
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Expression of CD94 and NKG2 molecules on human CD4(+) T cells in response to CD3-mediated stimulation.
Romero P, Ortega C, Palma A, Molina IJ, Peña J, Santamaría M
J Leukoc Biol. 2001
PubMed ID: 11493613
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Structural basis of MHC class I recognition by natural killer cell receptors.
Sawicki MW, Dimasi N, Natarajan K, Wang J, Margulies DH, Mariuzza RA
Immunol Rev. 2001
PubMed ID: 11513152
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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The genomic organization of the mouse CD94 C-type lectin gene.
Lohwasser S, Wilhelm B, Mager DL, Takei F
Eur J Immunogenet. 2000
PubMed ID: 10940084
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Sequence-ready BAC contig, physical, and transcriptional map of a 2-Mb region overlapping the mouse chromosome 6 host-resistance locus Cmv1.
Depatie C, Lee SH, Stafford A, Avner P, Belouchi A, Gros P, Vidal SM
Genomics. 2000
PubMed ID: 10860661
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Human KLRF1, a novel member of the killer cell lectin-like receptor gene family: molecular characterization, genomic structure, physical mapping to the NK gene complex and expression analysis.
Roda-Navarro P, Arce I, Renedo M, Montgomery K, Kucherlapati R, Fernández-Ruiz E
Eur J Immunol. 2000
PubMed ID: 10671213
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Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells.
Vance RE, Jamieson AM, Raulet DH
J Exp Med. 1999
PubMed ID: 10601355
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Assessment of Cmv1 candidates by genetic mapping and in vivo antibody depletion of NK cell subsets.
Depatie C, Chalifour A, Paré C, Lee SH, Vidal SM, Lemieux S
Int Immunol. 1999
PubMed ID: 10464175
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Close genetic linkage of Chok with the NKC-linked loci Cd94, Ly49, and Cmv1 on mouse chromosome 6.
Idris AH, Scalzo AA, Yokoyama WM
Immunogenetics. 1999
PubMed ID: 10436186
-
Localization on a physical map of the NKC-linked Cmv1 locus between Ly49b and the Prp gene cluster on mouse chromosome 6.
Brown MG, Zhang J, Du Y, Stoll J, Yokoyama WM, Scalzo AA
J Immunol. 1999
PubMed ID: 10438936
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Direct binding of purified HLA class I antigens by soluble NKG2/CD94 C-type lectins from natural killer cells.
Ding Y, Sumitran S, Holgersson J
Scand J Immunol. 1999
PubMed ID: 10320637
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Triggering of effector functions on a CD8+ T cell clone upon the aggregation of an activatory CD94/kp39 heterodimer.
Bellón T, Heredia AB, Llano M, Minguela A, Rodriguez A, López-Botet M, Aparicio P
J Immunol. 1999
PubMed ID: 10201920
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Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci.
Scalzo AA, Brown MG, Chu DT, Heusel JW, Yokoyama WM, Forbes CA
Immunogenetics. 1999
PubMed ID: 9914339
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Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells.
Brooks AG, Borrego F, Posch PE, Patamawenu A, Scorzelli CJ, Ulbrecht M, Weiss EH, Coligan JE
J Immunol. 1999
PubMed ID: 9886400
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.
Boyington JC, Riaz AN, Patamawenu A, Coligan JE, Brooks AG, Sun PD
Immunity. 1999
PubMed ID: 10023772
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Mouse CD94/NKG2A is a natural killer cell receptor for the nonclassical major histocompatibility complex (MHC) class I molecule Qa-1(b).
Vance RE, Kraft JR, Altman JD, Jensen PE, Raulet DH
J Exp Med. 1998
PubMed ID: 9815261
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Association of DAP12 with activating CD94/NKG2C NK cell receptors.
Lanier LL, Corliss B, Wu J, Phillips JH
Immunity. 1998
PubMed ID: 9655483
-
An alternatively spliced form of the human CD94 gene.
Furukawa H, Yabe T, Watanabe K, Miyamoto R, Akaza T, Tadokoro K, Tohma S, Inoue T, Yamamoto K, Juji T
Immunogenetics. 1998
PubMed ID: 9601951
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Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells.
Ho EL, Heusel JW, Brown MG, Matsumoto K, Scalzo AA, Yokoyama WM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9600963
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Sequence analysis of a 62-kb region overlapping the human KLRC cluster of genes.
Plougastel B, Trowsdale J
Genomics. 1998
PubMed ID: 9598306
-
Structure of the human CD94 C-type lectin gene.
Rodríguez A, Carretero M, Glienke J, Bellón T, Ramírez A, Lehrach H, Francis F, López-Botet M
Immunogenetics. 1998
PubMed ID: 9472066
-
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
Braud VM, Allan DS, O'Callaghan CA, Söderström K, D'Andrea A, Ogg GS, Lazetic S, Young NT, Bell JI, Phillips JH, Lanier LL, McMichael AJ
Nature. 1998
PubMed ID: 9486650
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Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.
Le Dréan E, Vély F, Olcese L, Cambiaggi A, Guia S, Krystal G, Gervois N, Moretta A, Jotereau F, Vivier E
Eur J Immunol. 1998
PubMed ID: 9485206
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Multiple receptors for HLA-G on human natural killer cells.
Mandelboim O, Pazmany L, Davis DM, Valés-Gómez M, Reyburn HT, Rybalov B, Strominger JL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9405670
-
Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells.
Vance RE, Tanamachi DM, Hanke T, Raulet DH
Eur J Immunol. 1997
PubMed ID: 9464811
-
Molecular characterization of a gene in the rat homologous to human CD94.
Dissen E, Berg SF, Westgaard IH, Fossum S
Eur J Immunol. 1997
PubMed ID: 9295048
-
NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor.
Brooks AG, Posch PE, Scorzelli CJ, Borrego F, Coligan JE
J Exp Med. 1997
PubMed ID: 9034158
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Human natural killer cell receptors involved in MHC class I recognition are disulfide-linked heterodimers of CD94 and NKG2 subunits.
Lazetic S, Chang C, Houchins JP, Lanier LL, Phillips JH
J Immunol. 1996
PubMed ID: 8943374
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CD94 and a novel associated protein (94AP) form a NK cell receptor involved in the recognition of HLA-A, HLA-B, and HLA-C allotypes.
Phillips JH, Chang C, Mattson J, Gumperz JE, Parham P, Lanier LL
Immunity. 1996
PubMed ID: 8769479
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Molecular characterization of human CD94: a type II membrane glycoprotein related to the C-type lectin superfamily.
Chang C, Rodríguez A, Carretero M, López-Botet M, Phillips JH, Lanier LL
Eur J Immunol. 1995
PubMed ID: 7589107
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Human natural killer cell receptors for HLA-class I molecules. Evidence that the Kp43 (CD94) molecule functions as receptor for HLA-B alleles.
Moretta A, Vitale M, Sivori S, Bottino C, Morelli L, Augugliaro R, Barbaresi M, Pende D, Ciccone E, Lopez-Botet M, Moretta L
J Exp Med. 1994
PubMed ID: 8046333
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