ARF6

Summary Top Help

Gene Description:

ADP-ribosylation factor 6

Synonyms:

AW496366, Arf6, ARF6, AI788669

Orthologs:

Human ARF6 (protein-coding), Mouse Arf6 (protein-coding), Rat Arf6 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr14:50359736..50363772 (44 kb) View in Genome Browser

(Mouse) NCBIM37 - chr12:70473137..70476967 (3.83 kb) View in Genome Browser

(Rat) RGSC3.4 - chr6:91337496..91338644 (1.15 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ARF6:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ARF6:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 2

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 9

Gene Ontology: 36

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 182

Macropinocytosis inhibitors and Arf6 regulate ErbB3 nuclear localization in prostate cancer cells.
Koumakpayi IH, Le Page C, Delvoye N, Saad F, Mes-Masson AM
Mol Carcinog. 2011
PubMed ID: 21438025
Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein.
Sakurai A, Jian X, Lee CJ, Manavski Y, Chavakis E, Donaldson J, Randazzo PA, Gutkind JS
J Biol Chem. 2011
PubMed ID: 21795701
Arf6 regulates AP-1B-dependent sorting in polarized epithelial cells.
Shteyn E, Pigati L, Fölsch H
J Cell Biol. 2011
PubMed ID: 21911479
Distinct roles of Rab11 and Arf6 in the regulation of Rab11-FIP3/arfophilin-1 localization in mitotic cells.
Takahashi S, Takei T, Koga H, Takatsu H, Shin HW, Nakayama K
Genes Cells. 2011
PubMed ID: 21790911
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21825135
Cholesterol modulates the rate and mechanism of acetylcholine receptor internalization.
Borroni V, Barrantes FJ
J Biol Chem. 2011
PubMed ID: 21357688
HIV-1 requires Arf6-mediated membrane dynamics to efficiently enter and infect T lymphocytes.
García-Expósito L, Barroso-González J, Puigdomènech I, Machado JD, Blanco J, Valenzuela-Fernández A
Mol Biol Cell. 2011
PubMed ID: 21346189
Decoupling of activation and effector binding underlies ARF6 priming of fast endocytic recycling.
Montagnac G, de Forges H, Smythe E, Gueudry C, Romao M, Salamero J, Chavrier P
Curr Biol. 2011
PubMed ID: 21439824
Regulation of PIP5K activity by Arf6 and its physiological significance.
Funakoshi Y, Hasegawa H, Kanaho Y
J Cell Physiol. 2011
PubMed ID: 20945365
[Arf6, RalA and BIRC5 protein expression in non small cell lung cancer].
Knizhnik AV, Kovaleva OB, Laktionov KK, Mochal'nikova VV, Komel'kov AV, Chevkina EM, Zborovskaia IB
Mol Biol (Mosk). 2011
PubMed ID: 21634118
Mono-ADP-ribosylation of the G protein betagamma dimer is modulated by hormones and inhibited by Arf6.
Dani N, Mayo E, Stilla A, Marchegiani A, Di Paola S, Corda D, Di Girolamo M
J Biol Chem. 2011
PubMed ID: 21148312
GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H
PLoS One. 2011
PubMed ID: 21858086
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Tissue- and development-dependent expression of the small GTPase Arf6 in mice.
Akiyama M, Zhou M, Sugimoto R, Hongu T, Furuya M, Funakoshi Y, Kato M, Hasegawa H, Kanaho Y
Dev Dyn. 2010
PubMed ID: 21069828
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
Gorbea C, Pratt G, Ustrell V, Bell R, Sahasrabudhe S, Hughes RE, Rechsteiner M
J Biol Chem. 2010
PubMed ID: 20682791
c-Myc stimulates cell invasion by inhibiting FBX8 function.
Cho HJ, Oh YJ, Kwon J, Kwon JY, Kim KS, Kim H
Mol Cells. 2010
PubMed ID: 20848231
Induction of nonapoptotic cell death by activated Ras requires inverse regulation of Rac1 and Arf6.
Bhanot H, Young AM, Overmeyer JH, Maltese WA
Mol Cancer Res. 2010
PubMed ID: 20713492
SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6.
Biou V, Aizel K, Roblin P, Thureau A, Jacquet E, Hansson S, Guibert B, Guittet E, van Heijenoort C, Zeghouf M, Perez J, Cherfils J
J Mol Biol. 2010
PubMed ID: 20709080
The guanine nucleotide exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2, regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process.
Someya A, Moss J, Nagaoka I
J Biol Chem. 2010
PubMed ID: 20601426
TBC1D24, an ARF6-interacting protein, is mutated in familial infantile myoclonic epilepsy.
Falace A, Filipello F, La Padula V, Vanni N, Madia F, De Pietri Tonelli D, de Falco FA, Striano P, Dagna Bricarelli F, Minetti C, Benfenati F, Fassio A, Zara F
Am J Hum Genet. 2010
PubMed ID: 20727515
Cytohesin-2/ARNO, through its interaction with focal adhesion adaptor protein paxillin, regulates preadipocyte migration via the downstream activation of Arf6.
Torii T, Miyamoto Y, Sanbe A, Nishimura K, Yamauchi J, Tanoue A
J Biol Chem. 2010
PubMed ID: 20525696
ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.
Bach AS, Enjalbert S, Comunale F, Bodin S, Vitale N, Charrasse S, Gauthier-Rouvière C
Mol Biol Cell. 2010
PubMed ID: 20505075
The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.
Suzuki A, Arikawa C, Kuwahara Y, Itoh K, Watanabe M, Watanabe H, Suzuki T, Funakoshi Y, Hasegawa H, Kanaho Y
FEBS Lett. 2010
PubMed ID: 20493856
Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis.
Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C
Mol Biol Cell. 2010
PubMed ID: 20462959
AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.
Scholz R, Berberich S, Rathgeber L, Kolleker A, Köhr G, Kornau HC
Neuron. 2010
PubMed ID: 20547133
Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.
Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R, Gutkind JS
Mol Cell Biol. 2010
PubMed ID: 20385769
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
Ismail SA, Vetter IR, Sot B, Wittinghofer A
Cell. 2010
PubMed ID: 20510928
ADP-ribosylation factor 6 modulates adrenergic stimulated lipolysis in adipocytes.
Liu Y, Zhou D, Abumrad NA, Su X
Am J Physiol Cell Physiol. 2010
PubMed ID: 20107045
Internalization of coxsackievirus A9 is mediated by {beta}2-microglobulin, dynamin, and Arf6 but not by caveolin-1 or clathrin.
Heikkilä O, Susi P, Tevaluoto T, Härmä H, Marjomäki V, Hyypiä T, Kiljunen S
J Virol. 2010
PubMed ID: 20089652
AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
Wan T, Liu T, Zhang H, Tang S, Min W
J Biol Chem. 2010
PubMed ID: 19948740
Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion.
El Azreq MA, Garceau V, Harbour D, Pivot-Pajot C, Bourgoin SG
J Immunol. 2010
PubMed ID: 20018626
FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.
Ikenouchi J, Umeda M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080746
Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.
Yanase Y, Carvou N, Frohman MA, Cockcroft S
Biochem J. 2010
PubMed ID: 19845506
ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.
Rankovic M, Jacob L, Rankovic V, Brandenburg LO, Schröder H, Höllt V, Koch T
Cell Signal. 2009
PubMed ID: 19666113
Clathrin-independent internalization of normal cellular prion protein in neuroblastoma cells is associated with the Arf6 pathway.
Kang YS, Zhao X, Lovaas J, Eisenberg E, Greene LE
J Cell Sci. 2009
PubMed ID: 19843586
Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY
Nat Cell Biol. 2009
PubMed ID: 19855388
Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.
Li M, Wang J, Ng SS, Chan CY, He ML, Yu F, Lai L, Shi C, Chen Y, Yew DT, Kung HF, Lin MC
Cancer. 2009
PubMed ID: 19642173
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC
J Biol Chem. 2009
PubMed ID: 19622751
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.
Isabet T, Montagnac G, Regazzoni K, Raynal B, El Khadali F, England P, Franco M, Chavrier P, Houdusse A, Ménétrey J
EMBO J. 2009
PubMed ID: 19644450
Dual acylation is required for trafficking of growth-associated protein-43 (GAP-43) to endosomal recycling compartment via an Arf6-associated endocytic vesicular pathway.
Trenchi A, Gomez GA, Daniotti JL
Biochem J. 2009
PubMed ID: 19442238
Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.
Yamauchi J, Miyamoto Y, Torii T, Mizutani R, Nakamura K, Sanbe A, Koide H, Kusakawa S, Tanoue A
Exp Cell Res. 2009
PubMed ID: 19327349
ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes.
Lu L, Khan A, Walker WA
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 19359423
Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton.
Jing J, Tarbutton E, Wilson G, Prekeris R
Eur J Cell Biol. 2009
PubMed ID: 19327867
Secretory Carrier Membrane Protein 2 Regulates Cell-surface Targeting of Brain-enriched Na+/H+ Exchanger NHE5.
Diering GH, Church J, Numata M
J Biol Chem. 2009
PubMed ID: 19276089
ERK MAP kinase-activated Arf6 trafficking directs coxsackievirus type B3 into an unproductive compartment during virus host-cell entry.
Marchant D, Sall A, Si X, Abraham T, Wu W, Luo Z, Petersen T, Hegele RG, McManus BM
J Gen Virol. 2009
PubMed ID: 19264606
EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.
Miura K, Nam JM, Kojima C, Mochizuki N, Sabe H
Mol Biol Cell. 2009
PubMed ID: 19193766
ARF6 regulates the synthesis of fusogenic lipids for calcium-regulated exocytosis in neuroendocrine cells.
Béglé A, Tryoen-Tóth P, de Barry J, Bader MF, Vitale N
J Biol Chem. 2009
PubMed ID: 19124467
ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.
Montagnac G, Sibarita JB, Loubéry S, Daviet L, Romao M, Raposo G, Chavrier P
Curr Biol. 2009
PubMed ID: 19211056
Src-dependent repression of ARF6 is required to maintain podosome-rich sealing zones in bone-digesting osteoclasts.
Heckel T, Czupalla C, Expirto Santo AI, Anitei M, Arantzazu Sanchez-Fernandez M, Mosch K, Krause E, Hoflack B
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19164586
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.
Hu B, Shi B, Jarzynka MJ, Yiin JJ, D'Souza-Schorey C, Cheng SY
Cancer Res. 2009
PubMed ID: 19155310
Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.
Deribe YL, Wild P, Chandrashaker A, Curak J, Schmidt MH, Kalaidzidis Y, Milutinovic N, Kratchmarova I, Buerkle L, Fetchko MJ, Schmidt P, Kittanakom S, Brown KR, Jurisica I, Blagoev B, Zerial M, Stagljar I, Dikic I
Sci Signal. 2009
PubMed ID: 20029029
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ
Sci Signal. 2009
PubMed ID: 19738201
Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.
Anthonio EA, Brees C, Baumgart-Vogt E, Hongu T, Huybrechts SJ, Van Dijck P, Mannaerts GP, Kanaho Y, Van Veldhoven PP, Fransen M
BMC Cell Biol. 2009
PubMed ID: 19686593
ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease.
Schweitzer JK, Pietrini SD, D'Souza-Schorey C
PLoS One. 2009
PubMed ID: 19365558
The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
Lau AW, Chou MM
J Cell Sci. 2008
PubMed ID: 19033387
Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity.
Daher Z, Noël J, Claing A
Cell Signal. 2008
PubMed ID: 18814847
Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes.
Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, Sakagami H
Brain Res. 2008
PubMed ID: 18708035
Arf family GTP loading is activated by, and generates, positive membrane curvature.
Lundmark R, Doherty GJ, Vallis Y, Peter BJ, McMahon HT
Biochem J. 2008
PubMed ID: 18597672
Sequential Cyk-4 binding to ECT2 and FIP3 regulates cleavage furrow ingression and abscission during cytokinesis.
Simon GC, Schonteich E, Wu CC, Piekny A, Ekiert D, Yu X, Gould GW, Glotzer M, Prekeris R
EMBO J. 2008
PubMed ID: 18511905
Role of ARF6 in internalization of metal-binding proteins, metallothionein and transferrin, and cadmium-metallothionein toxicity in kidney proximal tubule cells.
Wolff NA, Lee WK, Abouhamed M, Thévenod F
Toxicol Appl Pharmacol. 2008
PubMed ID: 18353411
Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation.
Karim ZA, Choi W, Whiteheart SW
J Biol Chem. 2008
PubMed ID: 18326492
Sequence analysis of the SRGN, AP3B1, ARF6, and SH2D1A genes in familial hemophagocytic lymphohistiocytosis.
Ma D, Rudd E, Edner J, Gavhed S, Ramme KG, Fadeel B, Nordenskjöld M, Henter JI, Zheng C
Pediatr Blood Cancer. 2008
PubMed ID: 18000860
Clathrin dependent endocytosis of E-cadherin is regulated by the Arf6GAP isoform SMAP1.
Kon S, Tanabe K, Watanabe T, Sabe H, Satake M
Exp Cell Res. 2008
PubMed ID: 18331728
A role for ARF6 in dendritic cell podosome formation and migration.
Svensson HG, West MA, Mollahan P, Prescott AR, Zaru R, Watts C
Eur J Immunol. 2008
PubMed ID: 18286566
Fbx8 makes Arf6 refractory to function via ubiquitination.
Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H
Mol Biol Cell. 2008
PubMed ID: 18094045
IQ-ArfGEF/BRAG1 is a guanine nucleotide exchange factor for Arf6 that interacts with PSD-95 at postsynaptic density of excitatory synapses.
Sakagami H, Sanda M, Fukaya M, Miyazaki T, Sukegawa J, Yanagisawa T, Suzuki T, Fukunaga K, Watanabe M, Kondo H
Neurosci Res. 2008
PubMed ID: 18164504
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H
Nat Cell Biol. 2008
PubMed ID: 18084281
Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts.
Balasubramanian N, Scott DW, Castle JD, Casanova JE, Schwartz MA
Nat Cell Biol. 2007
PubMed ID: 18026091
A Role for ARF6 and ARNO in the regulation of endosomal dynamics in neurons.
Hernández-Deviez D, Mackay-Sim A, Wilson JM
Traffic. 2007
PubMed ID: 17897316
ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin.
Poupart ME, Fessart D, Cotton M, Laporte SA, Claing A
Cell Signal. 2007
PubMed ID: 17719203
Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
Schonteich E, Pilli M, Simon GC, Matern HT, Junutula JR, Sentz D, Holmes RK, Prekeris R
Eur J Cell Biol. 2007
PubMed ID: 17628206
The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.
Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM
J Cell Sci. 2007
PubMed ID: 17623778
Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.
Haynes LP, Sherwood MW, Dolman NJ, Burgoyne RD
Traffic. 2007
PubMed ID: 17555535
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2.
Dunphy JL, Ye K, Casanova JE
Traffic. 2007
PubMed ID: 17461797
The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
Hofmann I, Thompson A, Sanderson CM, Munro S
Curr Biol. 2007
PubMed ID: 17398095
Endogenous ARF6 interacts with Rac1 upon angiotensin II stimulation to regulate membrane ruffling and cell migration.
Cotton M, Boulay PL, Houndolo T, Vitale N, Pitcher JA, Claing A
Mol Biol Cell. 2007
PubMed ID: 17122362
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation.
Koo TH, Eipper BA, Donaldson JG
BMC Cell Biol. 2007
PubMed ID: 17640372
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Role of endosomal Rab GTPases in cytokinesis.
Yu X, Prekeris R, Gould GW
Eur J Cell Biol. 2007
PubMed ID: 17157409
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP.
Yoon HY, Miura K, Cuthbert EJ, Davis KK, Ahvazi B, Casanova JE, Randazzo PA
J Cell Sci. 2006
PubMed ID: 17077126
Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.
Shiba T, Koga H, Shin HW, Kawasaki M, Kato R, Nakayama K, Wakatsuki S
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17030804
Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-ribosylation factor (ARF).
Johnson MS, Robertson DN, Holland PJ, Lutz EM, Mitchell R
Cell Signal. 2006
PubMed ID: 16545942
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development.
Suzuki T, Kanai Y, Hara T, Sasaki J, Sasaki T, Kohara M, Maehama T, Taya C, Shitara H, Yonekawa H, Frohman MA, Yokozeki T, Kanaho Y
Mol Cell Biol. 2006
PubMed ID: 16880525
Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4.
Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard JW, Powell M, Chen Y, Forte JG, Yao X
Mol Cell Proteomics. 2006
PubMed ID: 16737952
Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain.
Sakagami H, Suzuki H, Kamata A, Owada Y, Fukunaga K, Mayanagi H, Kondo H
Brain Res. 2006
PubMed ID: 16707115
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling.
Kagan JC, Medzhitov R
Cell. 2006
PubMed ID: 16751103
A phosphatidylinositol-3-kinase-dependent signal transition regulates ARF1 and ARF6 during Fcgamma receptor-mediated phagocytosis.
Beemiller P, Hoppe AD, Swanson JA
PLoS Biol. 2006
PubMed ID: 16669702
ARNO through its coiled-coil domain regulates endocytosis at the apical surface of polarized epithelial cells.
Shmuel M, Santy LC, Frank S, Avrahami D, Casanova JE, Altschuler Y
J Biol Chem. 2006
PubMed ID: 16484220
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport.
Klein S, Franco M, Chardin P, Luton F
J Biol Chem. 2006
PubMed ID: 16527809
ARF6 and EFA6A regulate the development and maintenance of dendritic spines.
Choi S, Ko J, Lee JR, Lee HW, Kim K, Chung HS, Kim H, Kim E
J Neurosci. 2006
PubMed ID: 16672654
ACRP30 is secreted from 3T3-L1 adipocytes via a Rab11-dependent pathway.
Clarke M, Ewart MA, Santy LC, Prekeris R, Gould GW
Biochem Biophys Res Commun. 2006
PubMed ID: 16516854
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Regulation of neuroendocrine exocytosis by the ARF6 GTPase-activating protein GIT1.
Meyer MZ, Déliot N, Chasserot-Golaz S, Premont RT, Bader MF, Vitale N
J Biol Chem. 2006
PubMed ID: 16439353
The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.
Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, Casanova JE
Curr Biol. 2006
PubMed ID: 16461286
V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway.
Hurtado-Lorenzo A, Skinner M, El Annan J, Futai M, Sun-Wada GH, Bourgoin S, Casanova J, Wildeman A, Bechoua S, Ausiello DA, Brown D, Marshansky V
Nat Cell Biol. 2006
PubMed ID: 16415858
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
The small GTPase ADP-ribosylation factor 6 negatively regulates dendritic spine formation.
Miyazaki H, Yamazaki M, Watanabe H, Maehama T, Yokozeki T, Kanaho Y
FEBS Lett. 2005
PubMed ID: 16325184
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
Binding and functions of ADP-ribosylation factor on mammalian and yeast peroxisomes.
Lay D, L Grosshans B, Heid H, Gorgas K, Just WW
J Biol Chem. 2005
PubMed ID: 16100119
The DOCK180/Elmo complex couples ARNO-mediated Arf6 activation to the downstream activation of Rac1.
Santy LC, Ravichandran KS, Casanova JE
Curr Biol. 2005
PubMed ID: 16213822
Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.
Fielding AB, Schonteich E, Matheson J, Wilson G, Yu X, Hickson GR, Srivastava S, Baldwin SA, Prekeris R, Gould GW
EMBO J. 2005
PubMed ID: 16148947
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
The Small GTPase RalA controls exocytosis of large dense core secretory granules by interacting with ARF6-dependent phospholipase D1.
Vitale N, Mawet J, Camonis J, Regazzi R, Bader MF, Chasserot-Golaz S
J Biol Chem. 2005
PubMed ID: 15980073
Structural basis for the activation of cholera toxin by human ARF6-GTP.
O'Neal CJ, Jobling MG, Holmes RK, Hol WG
Science. 2005
PubMed ID: 16099990
Arf6: a new player in FcgammaRIIIA lymphocyte-mediated cytotoxicity.
Galandrini R, Micucci F, Tassi I, Cifone MG, Cinque B, Piccoli M, Frati L, Santoni A
Blood. 2005
PubMed ID: 15817676
The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes.
Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M
J Biol Chem. 2005
PubMed ID: 15802264
ARF6 GTPase controls bacterial invasion by actin remodelling.
Balañá ME, Niedergang F, Subtil A, Alcover A, Chavrier P, Dautry-Varsat A
J Cell Sci. 2005
PubMed ID: 15897187
Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells.
Matsuya S, Sakagami H, Tohgo A, Owada Y, Shin HW, Takeshima H, Nakayama K, Kokubun S, Kondo H
J Neurochem. 2005
PubMed ID: 15836626
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P
Nat Cell Biol. 2005
PubMed ID: 15793564
A novel GTPase-activating protein for ARF6 directly interacts with clathrin and regulates clathrin-dependent endocytosis.
Tanabe K, Torii T, Natsume W, Braesch-Andersen S, Watanabe T, Satake M
Mol Biol Cell. 2005
PubMed ID: 15659652
Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis.
Ikeda S, Ushio-Fukai M, Zuo L, Tojo T, Dikalov S, Patrushev NA, Alexander RW
Circ Res. 2005
PubMed ID: 15692085
G protein-coupled receptor endocytosis in ADP-ribosylation factor 6-depleted cells.
Houndolo T, Boulay PL, Claing A
J Biol Chem. 2005
PubMed ID: 15590645
Requirement of phosphatidylinositol-4,5-bisphosphate for HERC1-mediated guanine nucleotide release from ARF proteins.
Garcia-Gonzalo FR, Bartrons R, Ventura F, Rosa JL
FEBS Lett. 2005
PubMed ID: 15642342
Nef: "necessary and enforcing factor" in HIV infection.
Joseph AM, Kumar M, Mitra D
Curr HIV Res. 2005
PubMed ID: 15638726
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.
Martinu L, Masuda-Robens JM, Robertson SE, Santy LC, Casanova JE, Chou MM
Mol Cell Biol. 2004
PubMed ID: 15509780
Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.
Ono A, Ablan SD, Lockett SJ, Nagashima K, Freed EO
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15465916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function.
Hashimoto S, Hashimoto A, Yamada A, Kojima C, Yamamoto H, Tsutsumi T, Higashi M, Mizoguchi A, Yagi R, Sabe H
J Biol Chem. 2004
PubMed ID: 15231847
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Tague SE, Muralidharan V, D'Souza-Schorey C
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15210957
Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D
Mol Biol Cell. 2004
PubMed ID: 14978216
Requirement for Arf6 in breast cancer invasive activities.
Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, Yamada A, Sabe H
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15087504
Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situ.
El-Annan J, Brown D, Breton S, Bourgoin S, Ausiello DA, Marshansky V
Am J Physiol Cell Physiol. 2004
PubMed ID: 14684384
Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization.
Venkateswarlu K, Brandom KG, Lawrence JL
J Biol Chem. 2004
PubMed ID: 14625293
Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11.
Powelka AM, Sun J, Li J, Gao M, Shaw LM, Sonnenberg A, Hsu VW
Traffic. 2004
PubMed ID: 14675422
HIV Nef-mediated major histocompatibility complex class I down-modulation is independent of Arf6 activity.
Larsen JE, Massol RH, Nieland TJ, Kirchhausen T
Mol Biol Cell. 2004
PubMed ID: 14617802
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector.
Prigent M, Dubois T, Raposo G, Derrien V, Tenza D, Rossé C, Camonis J, Chavrier P
J Cell Biol. 2003
PubMed ID: 14662749
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Sequence, genomic organization, and expression of the human ADP-ribosylation factor 6 (ARF6) gene: a class III ARF.
Lebeda RA, Johnson SK, Stewart MI, Haun RS
DNA Cell Biol. 2003
PubMed ID: 14659046
Requirement for Arf6 in cell adhesion, migration, and cancer cell invasion.
Sabe H
J Biochem. 2003
PubMed ID: 14607973
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
Matsukawa J, Nakayama K, Nagao T, Ichijo H, Urushidani T
J Biol Chem. 2003
PubMed ID: 12860984
ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor.
Mitchell R, Robertson DN, Holland PJ, Collins D, Lutz EM, Johnson MS
J Biol Chem. 2003
PubMed ID: 12799371
Differential localization and function of ADP-ribosylation factor-6 in anergic human T cells: a potential marker for their identification.
Tzachanis D, Appleman LJ, Van Puijenbroek AA, Berezovskaya A, Nadler LM, Boussiotis VA
J Immunol. 2003
PubMed ID: 12902467
ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.
Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V
J Cell Biol. 2003
PubMed ID: 12847086
ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages.
Niedergang F, Colucci-Guyon E, Dubois T, Raposo G, Chavrier P
J Cell Biol. 2003
PubMed ID: 12810696
Alterations in the Arf6-regulated plasma membrane endosomal recycling pathway in cells overexpressing the tetraspan protein Gas3/PMP22.
Chies R, Nobbio L, Edomi P, Schenone A, Schneider C, Brancolini C
J Cell Sci. 2003
PubMed ID: 12584243
Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.
Xu L, Frankel P, Jackson D, Rotunda T, Boshans RL, D'Souza-Schorey C, Foster DA
Mol Cell Biol. 2003
PubMed ID: 12509462
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
HIV-1 Nef downregulates MHC-I by a PACS-1- and PI3K-regulated ARF6 endocytic pathway.
Blagoveshchenskaya AD, Thomas L, Feliciangeli SF, Hung CH, Thomas G
Cell. 2002
PubMed ID: 12526811
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane.
Vitale N, Chasserot-Golaz S, Bailly Y, Morinaga N, Frohman MA, Bader MF
J Cell Biol. 2002
PubMed ID: 12379803
Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis.
Schweitzer JK, D'Souza-Schorey C
J Biol Chem. 2002
PubMed ID: 12016212
Regulation of dendritic development by the ARF exchange factor ARNO.
Hernández-Deviez DJ, Casanova JE, Wilson JM
Nat Neurosci. 2002
PubMed ID: 12032543
A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane.
Caplan S, Naslavsky N, Hartnell LM, Lodge R, Polishchuk RS, Donaldson JG, Bonifacino JS
EMBO J. 2002
PubMed ID: 12032069
Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.
Mukherjee S, Gurevich VV, Preninger A, Hamm HE, Bader MF, Fazleabas AT, Birnbaumer L, Hunzicker-Dunn M
J Biol Chem. 2002
PubMed ID: 11867621
Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.
Austin C, Boehm M, Tooze SA
Biochemistry. 2002
PubMed ID: 11926829
Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells.
Powner DJ, Hodgkin MN, Wakelam MJ
Mol Biol Cell. 2002
PubMed ID: 11950936
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis.
Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ
J Biol Chem. 2001
PubMed ID: 11533043
Arfophilin is a common target of both class II and class III ADP-ribosylation factors.
Shin OH, Couvillon AD, Exton JH
Biochemistry. 2001
PubMed ID: 11535061
Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1.
Shin OH, Exton JH
Biochem Biophys Res Commun. 2001
PubMed ID: 11478794
Intra-endosomal pH-sensitive recruitment of the Arf-nucleotide exchange factor ARNO and Arf6 from cytoplasm to proximal tubule endosomes.
Maranda B, Brown D, Bourgoin S, Casanova JE, Vinay P, Ausiello DA, Marshansky V
J Biol Chem. 2001
PubMed ID: 11278939
The structural GDP/GTP cycle of human Arf6.
Pasqualato S, Ménétrey J, Franco M, Cherfils J
EMBO Rep. 2001
PubMed ID: 11266366
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z
Genome Res. 2000
PubMed ID: 11042152
Separation of membrane trafficking and actin remodeling functions of ARF6 with an effector domain mutant.
Al-Awar O, Radhakrishna H, Powell NN, Donaldson JG
Mol Cell Biol. 2000
PubMed ID: 10913182
A new paxillin-binding protein, PAG3/Papalpha/KIAA0400, bearing an ADP-ribosylation factor GTPase-activating protein activity, is involved in paxillin recruitment to focal adhesions and cell migration.
Kondo A, Hashimoto S, Yano H, Nagayama K, Mazaki Y, Sabe H
Mol Biol Cell. 2000
PubMed ID: 10749932
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.
Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho Y
Cell. 1999
PubMed ID: 10589680
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1.
Langille SE, Patki V, Klarlund JK, Buxton JM, Holik JJ, Chawla A, Corvera S, Czech MP
J Biol Chem. 1999
PubMed ID: 10480924
ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements.
Radhakrishna H, Al-Awar O, Khachikian Z, Donaldson JG
J Cell Sci. 1999
PubMed ID: 10036235
Identification of a new Pyk2 target protein with Arf-GAP activity.
Andreev J, Simon JP, Sabatini DD, Kam J, Plowman G, Randazzo PA, Schlessinger J
Mol Cell Biol. 1999
PubMed ID: 10022920
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Assignment of the human ADP-ribosylation factor 6 (ARF6) gene to chromosome 7q22.1 by radiation hybrid mapping.
Kim HS
Cytogenet Cell Genet. 1999
PubMed ID: 10343114
Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.
Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9653160
Subcellular distribution and differential expression of endogenous ADP-ribosylation factor 6 in mammalian cells.
Yang CZ, Heimberg H, D'Souza-Schorey C, Mueckler MM, Stahl PD
J Biol Chem. 1998
PubMed ID: 9461590
ARNO is a guanine nucleotide exchange factor for ADP-ribosylation factor 6.
Frank S, Upender S, Hansen SH, Casanova JE
J Biol Chem. 1998
PubMed ID: 9417041
A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.
D'Souza-Schorey C, Boshans RL, McDonough M, Stahl PD, Van Aelst L
EMBO J. 1997
PubMed ID: 9312003
Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).
Hosaka M, Toda K, Takatsu H, Torii S, Murakami K, Nakayama K
J Biochem. 1996
PubMed ID: 8947846
Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane.
Cavenagh MM, Whitney JA, Carroll K, Zhang C, Boman AL, Rosenwald AG, Mellman I, Kahn RA
J Biol Chem. 1996
PubMed ID: 8702973
Interspecies relationships among ADP-ribosylation factors (ARFs): evidence of evolutionary pressure to maintain individual identities.
Price SR, Nightingale MS, Tsuchiya M, Moss J, Vaughan M
Mol Cell Biochem. 1996
PubMed ID: 8813705
Myristoylation is required for the intracellular localization and endocytic function of ARF6.
D'Souza-Schorey C, Stahl PD
Exp Cell Res. 1995
PubMed ID: 7589240
A regulatory role for ARF6 in receptor-mediated endocytosis.
D'Souza-Schorey C, Li G, Colombo MI, Stahl PD
Science. 1995
PubMed ID: 7855600
Structure of the human ADP-ribosylation factor 1 complexed with GDP.
Amor JC, Harrison DH, Kahn RA, Ringe D
Nature. 1994
PubMed ID: 7990966
ADP-ribosylation factors: a family of approximately 20-kDa guanine nucleotide-binding proteins that activate cholera toxin.
Welsh CF, Moss J, Vaughan M
Mol Cell Biochem. 1994
PubMed ID: 7898460
Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells.
Schürmann A, Breiner M, Becker W, Huppertz C, Kainulainen H, Kentrup H, Joost HG
J Biol Chem. 1994
PubMed ID: 8195219
Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol.
Orcl L, Palmer DJ, Amherdt M, Rothman JE
Nature. 1993
PubMed ID: 8355790
Two distinct populations of ARF bound to Golgi membranes.
Helms JB, Palmer DJ, Rothman JE
J Cell Biol. 1993
PubMed ID: 8491770
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.
Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M
J Biol Chem. 1991
PubMed ID: 1993656
ADP-ribosylation factor is functionally and physically associated with the Golgi complex.
Stearns T, Willingham MC, Botstein D, Kahn RA
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2105501

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	382	11845	79121
EnsEMBL Gene(s)	ENSG00000165527	ENSMUSG00000044147	ENSRNOG00000004791
Unigene	Hs.525330	Mm.27308	Rn.6993
Homologene	ARF6	Arf6	Arf6
OMIM	600464	N/A	N/A
GeneCards	ARF6	N/A	N/A
Beta Cell Genomics	DT.455400 DT.86609000	DT.101739372 DT.489245 DT.493210 DT.91336168	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	382	11845	79121

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
ARF6	LRPPRC	IntAct, BioGRID	empirical	17353931
ARF6	TRIM28	IntAct	empirical	17353931
ARF6	AP3S2	BioGRID	empirical	11926829
ARF6	SF3A1	IntAct	empirical	17353931
ARF6	HYOU1	IntAct	empirical	17353931
ARF6	SMC2	IntAct	empirical	17353931
ARF6	EXOC5	HPRD, BioGRID	empirical	14662749
ARF6	NUDC	IntAct	empirical	17353931
ARF6	RUVBL2	BioGRID	empirical	17643375
ARF6	IMMT	IntAct	empirical	17353931
ARF6	DDX19B	IntAct	empirical	17353931
ARF6	CHRM3	HPRD, BioGRID	empirical	12799371
ARF6	CLIC1	IntAct	empirical	17353931
ARF6	CS	IntAct	empirical	17353931
ARF6	AP1B1	HPRD	empirical	11926829
ARF6	ZNF709	HPRD	empirical	16737952
ARF6	DCTN1	IntAct	empirical	17353931
ARF6	DDOST	IntAct	empirical	17353931
ARF6	DDX5	IntAct	empirical	17353931
ARF6	DHX9	IntAct	empirical	17353931
ARF6	DHPS	IntAct	empirical	17353931
ARF6	DYNC1H1	IntAct, BioGRID	empirical	17353931
ARF6	EGFR	IntAct, BioGRID	empirical	20029029
ARF6	EIF4G1	IntAct	empirical	17353931
ARF6	HSPA4L	IntAct	empirical	17353931
ARF6	KIAA0090	IntAct	empirical	17353931
ARF6	GGA3	BioGRID	empirical	20848231
ARF6	GANAB	IntAct	empirical	17353931
ARF6	KIAA0368	BioGRID	empirical	17353931
ARF6	PIP5K1C	HPRD, BioGRID	empirical	12847086
ARF6	TARDBP	IntAct	empirical	17353931
ARF6	SF3B1	IntAct	empirical	17353931
ARF6	SEC11A	IntAct	empirical	17353931
ARF6	PSD4	IntAct	empirical	21458045
ARF6	RABGAP1	IntAct	empirical	17353931
ARF6	ARFIP2	HPRD, IntAct, BioGRID	empirical	9312003 11478794
ARF6	RAB3GAP2	IntAct	empirical	17353931
ARF6	C20orf4	IntAct	empirical	17353931
ARF6	SERBP1	IntAct	empirical	17353931
ARF6	GART	IntAct	empirical	17353931
ARF6	FBXO8	BioGRID	empirical	18094045
ARF6	GDI2	IntAct	empirical	17353931
ARF6	CACYBP	IntAct	empirical	17353931
ARF6	GCLM	IntAct	empirical	17353931
ARF6	GLS	IntAct	empirical	17353931
ARF6	GOT2	IntAct	empirical	17353931
ARF6	GSPT1	IntAct	empirical	17353931
ARF6	GTF2I	IntAct	empirical	17353931
ARF6	ANXA2	IntAct	empirical	17353931
ARF6	HDLBP	IntAct	empirical	17353931
ARF6	HLA-B	IntAct	empirical	17353931
ARF6	APEX1	IntAct	empirical	17353931
ARF6	IMPDH2	IntAct	empirical	17353931
ARF6	EIF3E	IntAct	empirical	17353931
ARF6	EIF6	IntAct	empirical	17353931
ARF6	TRIM23	IntAct	empirical	17353931
ARF6	KIF5B	IntAct	empirical	17353931
ARF6	ARRB1	HPRD, BioGRID	empirical	11533043 11867621
ARF6	ARRB2	HPRD, BioGRID	empirical	11533043 11867621
ARF6	MAT2A	IntAct	empirical	17353931
ARF6	MCM3	IntAct	empirical	17353931
ARF6	MSH2	IntAct	empirical	17353931
ARF6	MTHFD1	IntAct	empirical	17353931
ARF6	HNRNPM	IntAct	empirical	17353931
ARF6	NASP	IntAct	empirical	17353931
ARF6	ACLY	IntAct	empirical	17353931
ARF6	SEPT2	IntAct	empirical	17353931
ARF6	OAT	IntAct	empirical	17353931
ARF6	ASAP1	BioGRID	empirical	18094045
ARF6	COPS4	IntAct	empirical	17353931
ARF6	IPO11	IntAct	empirical	17353931
ARF6	TRMT112	IntAct	empirical	17353931
ARF6	PFDN2	IntAct	empirical	17353931
ARF6	PFKP	IntAct	empirical	17353931
ARF6	PGD	IntAct	empirical	17353931
ARF6	ATP6V0C	HPRD	empirical	16415858
ARF6	ATP6V1C1	IntAct	empirical	16415858
ARF6	PLD1	HPRD, BioGRID	empirical	12379803
ARF6	PLS1	IntAct	empirical	17353931
ARF6	PCBP3	IntAct	empirical	17353931
ARF6	POLD1	IntAct	empirical	17353931
ARF6	HEATR2	IntAct	empirical	17353931
ARF6	ASAP3	HPRD	empirical	16737952
ARF6	RCC2	IntAct	empirical	17353931
ARF6	MEPCE	BioGRID	empirical	17643375
ARF6	NCLN	IntAct	empirical	17353931
ARF6	CCDC47	IntAct	empirical	17353931
ARF6	PSMD8	IntAct	empirical	17353931
ARF6	XPO5	IntAct	empirical	17353931
ARF6	ABCD3	BioGRID	empirical	19686593
ARF6	SRPRB	IntAct	empirical	17353931
ARF6	RALA	BioGRID	empirical	12509462
ARF6	RGS10	IntAct	empirical	17353931
ARF6	RPN1	IntAct	empirical	17353931
ARF6	RPN2	IntAct	empirical	17353931
ARF6	RPS29	IntAct	empirical	17353931
ARF6	SEC13	IntAct	empirical	17353931
ARF6	NCAPG	IntAct	empirical	17353931
ARF6	MPP5	HPRD	empirical	16737952
ARF6	SLC2A4	IntAct	empirical	16396496
ARF6	SLC3A2	IntAct	empirical	17353931
ARF6	SMARCC1	IntAct	empirical	17353931
ARF6	SNRPA1	IntAct	empirical	17353931
ARF6	SOD2	IntAct	empirical	17353931
ARF6	SRP14	IntAct	empirical	17353931
ARF6	SSR4	IntAct	empirical	17353931
ARF6	TALDO1	IntAct	empirical	17353931
ARF6	BTF3	IntAct	empirical	17353931
ARF6	TARS	IntAct	empirical	17353931
ARF6	UBC	BioGRID	empirical	18094045 20848231 21139048 21890473 21906983
ARF6	UBE2D3	IntAct	empirical	17353931
ARF6	UQCRC2	IntAct	empirical	17353931
ARF6	VHL	IntAct	empirical	17353931
ARF6	EZR	HPRD	empirical	16737952
ARF6	C6orf211	IntAct	empirical	17353931
ARF6	QTRT1	IntAct	empirical	17353931
ARF6	CAPN1	HPRD	empirical	16737952
ARF6	EPPK1	IntAct, BioGRID	empirical	17353931
ARF6	PIP5K1A	HPRD	empirical	10589680
ARF6	PEX3	BioGRID	empirical	19686593
ARF6	AP3B1	HPRD, BioGRID	empirical	11926829
ARF6	YARS	IntAct, BioGRID	empirical	17353931
ARF6	KHSRP	IntAct	empirical	17353931
ARF6	RUVBL1	IntAct	empirical	17353931
ARF6	USO1	IntAct	empirical	17353931
ARF6	RTCD1	IntAct	empirical	17353931
ARF6	EIF3G	IntAct	empirical	17353931
ARF6	EIF3I	IntAct	empirical	17353931
ARF6	PABPC4	IntAct, BioGRID	empirical	17353931
ARF6	IQGAP1	IntAct, BioGRID	empirical	17353931
ARF6	ASAP2	HPRD	empirical	10749932 10022920
ARF6	AP3D1	HPRD	empirical	11926829
ARF6	AIMP1	IntAct	empirical	17353931
ARF6	CYTH2	HPRD, BioGRID	empirical	9417041 18094045
ARF6	NPEPPS	IntAct	empirical	17353931
ARF6	EEF1E1	IntAct	empirical	17353931
ARF6	NUP93	IntAct	empirical	17353931
ARF6	RAB11FIP3	HPRD	empirical	11535061