ACAT1

Summary Top Help

Gene Description:

acetyl-CoA acetyltransferase 1; acetyl-Coenzyme A acetyltransferase 1

Synonyms:

ACAT1, 6330585C21Rik, RATACAL, Acat1, THIL, Acat, ACAT, MAT, T2

Orthologs:

Human ACAT1 (protein-coding), Mouse Acat1 (protein-coding), Rat Acat1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:107992243..108018895 (26.65 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:53388627..53418487 (29.86 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:57044478..57072970 (28.49 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ACAT1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ACAT1:

The ACAT1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
ACAT1	HDAC5	BioGRID	empirical	21081666
ACAT1	EIF1B	IntAct, BioGRID	empirical	17353931
ACAT1	BCKDK	Sanger Interaction Map	predicted	15345047
ACAT1	GABARAPL2	IntAct	empirical	20562859
ACAT1	DLG4	IntAct	empirical	19455133
ACAT1	AGXT	IntAct	empirical	21988832
ACAT1	ACSF3	Sanger Interaction Map	predicted	15345047
ACAT1	TNIK	IntAct	empirical	17353931
ACAT1	GH1	IntAct	empirical	17353931
ACAT1	HLA-B	IntAct	empirical	17353931
ACAT1	HLA-C	IntAct	empirical	17353931
ACAT1	HMGCR	Sanger Interaction Map	predicted	15345047
ACAT1	HMGCS1	Sanger Interaction Map	predicted	15345047
ACAT1	HNRNPK	IntAct	empirical	16518874
ACAT1	HSD17B4	Sanger Interaction Map	predicted	15345047
ACAT1	MCC	IntAct	empirical	17353931
ACAT1	MPG	IntAct	empirical	17353931
ACAT1	ACOX1	Sanger Interaction Map	predicted	15345047
ACAT1	COQ6	Sanger Interaction Map	predicted	15345047
ACAT1	MAPK3	MINT	empirical	19935650
ACAT1	SLC2A4	IntAct	empirical	16396496
ACAT1	UBC	BioGRID	empirical	21139048 21890473 21906983
ACAT1	YWHAB	IntAct	empirical	16635246
ACAT1	KMO	Sanger Interaction Map	predicted	15345047
ACAT1	CDYL	Sanger Interaction Map	predicted	15345047

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 11

Biocarta: 1

Reactome: 8

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 24

Publications from PubMed Top Help

Publications: 114

Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.
Maurer GD, Brucker DP, Bähr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J
BMC Cancer. 2011
PubMed ID: 21791085
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice.
Yoshinaka Y, Shibata H, Kobayashi H, Kuriyama H, Shibuya K, Tanabe S, Watanabe T, Miyazaki A
Atherosclerosis. 2010
PubMed ID: 20843517
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferation.
Antalis CJ, Arnold T, Rasool T, Lee B, Buhman KK, Siddiqui RA
Breast Cancer Res Treat. 2010
PubMed ID: 19851860
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
Pharmacogenomics. 2010
PubMed ID: 20602615
Cholesterol loading in macrophages stimulates formation of ER-derived vesicles with elevated ACAT1 activity.
Sakashita N, Chang CC, Lei X, Fujiwara Y, Takeya M, Chang TY
J Lipid Res. 2010
PubMed ID: 20460577
Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk.
Reynolds CA, Hong MG, Eriksson UK, Blennow K, Wiklund F, Johansson B, Malmberg B, Berg S, Alexeyenko A, Grönberg H, Gatz M, Pedersen NL, Prince JA
Hum Mol Genet. 2010
PubMed ID: 20167577
A common mutation, R208X, identified in Vietnamese patients with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.
Fukao T, Nguyen HT, Nguyen NT, Vu DC, Can NT, Pham AT, Nguyen KN, Kobayashi H, Hasegawa Y, Bui TP, Niezen-Koning KE, Wanders RJ, de Koning T, Nguyen LT, Yamaguchi S, Kondo N
Mol Genet Metab. 2010
PubMed ID: 20156697
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, LaFerla FM, Spencer TA, Hickey WF, Chang TY
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133765
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Different clinical presentation in siblings with mitochondrial acetoacetyl-CoA thiolase deficiency and identification of two novel mutations.
Thümmler S, Dupont D, Acquaviva C, Fukao T, de Ricaud D
Tohoku J Exp Med. 2010
PubMed ID: 20046049
Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.
Cho KH, Kim HJ, Kamanna VS, Vaziri ND
Biochim Biophys Acta. 2010
PubMed ID: 19878707
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway.
Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM
FASEB J. 2009
PubMed ID: 19625658
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages.
Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, Miyazaki A
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19625677
Study of the insulin signaling pathways in the regulation of ACAT1 expression in cultured macrophages.
Xin C, Yan-Fu W, Ping H, Jing G, Jing-Jing W, Chun-Li M, Wei L, Bei C
Cell Biol Int. 2009
PubMed ID: 19269342
Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells.
Antalis CJ, Arnold T, Lee B, Buhman KK, Siddiqui RA
Prostaglandins Leukot Essent Fatty Acids. 2009
PubMed ID: 19217763
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
Clin Chim Acta. 2009
PubMed ID: 18996102
Sterol regulatory element-binding proteins, liver X receptor, ABCA1 transporter, CD36, scavenger receptors A1 and B1 in nephrotic kidney.
Kim HJ, Vaziri ND
Am J Nephrol. 2009
PubMed ID: 19147991
[Genetic predisposition to systemic complications of arterial hypertension in maintenance haemodialysis patients]
Bzoma B, Debska-Slizień A, Dudziak M, Raczyńska K, Slizień W, Brylowska A, Rutkowski B
Pol Merkur Lekarski. 2008
PubMed ID: 19112833
Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages.
Kanome T, Watanabe T, Nishio K, Takahashi K, Hongo S, Miyazaki A
Hypertens Res. 2008
PubMed ID: 18971559
RNA secondary structures located in the interchromosomal region of human ACAT1 chimeric mRNA are required to produce the 56-kDa isoform.
Chen J, Zhao XN, Yang L, Hu GJ, Lu M, Xiong Y, Yang XY, Chang CC, Song BL, Chang TY, Li BL
Cell Res. 2008
PubMed ID: 18542101
Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes.
An S, Jang YS, Park JS, Kwon BM, Paik YK, Jeong TS
Exp Mol Med. 2008
PubMed ID: 18779653
The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.
Raman J, Fritz TA, Gerken TA, Jamison O, Live D, Liu M, Tabak LA
J Biol Chem. 2008
PubMed ID: 18562306
A novel single-base substitution (c.1124A>G) that activates a 5-base upstream cryptic splice donor site within exon 11 in the human mitochondrial acetoacetyl-CoA thiolase gene.
Fukao T, Boneh A, Aoki Y, Kondo N
Mol Genet Metab. 2008
PubMed ID: 18511318
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
Differential effects of PARP inhibition on vascular cell survival and ACAT-1 expression favouring atherosclerotic plaque stability.
Hans CP, Zerfaoui M, Naura AS, Catling A, Boulares AH
Cardiovasc Res. 2008
PubMed ID: 18245064
[Analysis of acyl-coenzyme A: cholesterol acyltransferase 1 polymorphism in patients with endogenous hypertriglyceridemia in Chinese population.]
Li Q, Bai H, Fan P, Liu R, Liu Y, Liu B
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
PubMed ID: 18393248
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT).
Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG
Prostate. 2008
PubMed ID: 18000807
Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice.
Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis AJ
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17916774
Functionality of the seventh and eighth transmembrane domains of acyl-coenzyme A:cholesterol acyltransferase 1.
Guo ZY, Chang CC, Chang TY
Biochemistry. 2007
PubMed ID: 17691824
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function.
Haapalainen AM, Meriläinen G, Pirilä PL, Kondo N, Fukao T, Wierenga RK
Biochemistry. 2007
PubMed ID: 17371050
Kinetic and expression analyses of seven novel mutations in mitochondrial acetoacetyl-CoA thiolase (T2): identification of a Km mutant and an analysis of the mutational sites in the structure.
Sakurai S, Fukao T, Haapalainen AM, Zhang G, Yamada K, Lilliu F, Yano S, Robinson P, Gibson MK, Wanders RJ, Mitchell GA, Wierenga RK, Kondo N
Mol Genet Metab. 2007
PubMed ID: 17236799
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages.
Bao L, Li Y, Deng SX, Landry D, Tabas I
J Biol Chem. 2006
PubMed ID: 16935859
A locus on mouse Chromosome 9 (Adip5) affects the relative weight of the gonadal but not retroperitoneal adipose depot.
McDaniel AH, Li X, Tordoff MG, Bachmanov AA, Reed DR
Mamm Genome. 2006
PubMed ID: 17103052
Identification of Alu-mediated, large deletion-spanning exons 2-4 in a patient with mitochondrial acetoacetyl-CoA thiolase deficiency.
Zhang G, Fukao T, Sakurai S, Yamada K, Michael Gibson K, Kondo N
Mol Genet Metab. 2006
PubMed ID: 16935016
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Mol Cell. 2006
PubMed ID: 16916647
Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe.
Kitayama K, Tanimoto T, Koga T, Terasaka N, Fujioka T, Inaba T
Eur J Pharmacol. 2006
PubMed ID: 16730694
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Genes of cholesterol metabolism in human atheroma: overexpression of perilipin and genes promoting cholesterol storage and repression of ABCA1 expression.
Forcheron F, Legedz L, Chinetti G, Feugier P, Letexier D, Bricca G, Beylot M
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15961705
ACAT1 deletion in murine macrophages associated with cytotoxicity and decreased expression of collagen type 3A1.
Rodriguez A, Ashen MD, Chen ES
Biochem Biophys Res Commun. 2005
PubMed ID: 15845358
Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1.
Su YR, Dove DE, Major AS, Hasty AH, Boone B, Linton MF, Fazio S
Circulation. 2005
PubMed ID: 15851589
Cerebral ketone body metabolism.
Morris AA
J Inherit Metab Dis. 2005
PubMed ID: 15877199
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV
Biochem J. 2004
PubMed ID: 15242332
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Mitochondrial acetoacetyl-CoA thiolase (T2) deficiency: T2-deficient patients with "mild" mutation(s) were previously misinterpreted as normal by the coupled assay with tiglyl-CoA.
Zhang GX, Fukao T, Rolland MO, Zabot MT, Renom G, Touma E, Kondo M, Matsuo N, Kondo N
Pediatr Res. 2004
PubMed ID: 15128923
The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.
Ohta T, Takata K, Katsuren K, Fukuyama S
Biochim Biophys Acta. 2004
PubMed ID: 15158756
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.
Temel RE, Gebre AK, Parks JS, Rudel LL
J Biol Chem. 2003
PubMed ID: 12975367
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Proteomic analysis of the mouse liver mitochondrial inner membrane.
Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC
J Biol Chem. 2003
PubMed ID: 12865426
Single base substitutions at the initiator codon in the mitochondrial acetoacetyl-CoA thiolase (ACAT1/T2) gene result in production of varying amounts of wild-type T2 polypeptide.
Fukao T, Matsuo N, Zhang GX, Urasawa R, Kubo T, Kohno Y, Kondo N
Hum Mutat. 2003
PubMed ID: 12754704
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts.
Hyogo H, Roy S, Paigen B, Cohen DE
J Biol Chem. 2002
PubMed ID: 12114517
Turnover of matrix proteins in mammalian mitochondria.
Huth W, Rolle S, Wunderlich I
Biochem J. 2002
PubMed ID: 11988101
The influence of chylomicron remnants on cholesteryl ester metabolism in cultured rat hepatocytes: comparison of the effects of particles enriched in n-3 or n-6 polyunsaturated fatty acids.
Botham KM, Maldonado EN, Chico Y, Zheng X, Avella M, Ochoa B
Biochim Biophys Acta. 2001
PubMed ID: 11786296
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages.
Fazio S, Major AS, Swift LL, Gleaves LA, Accad M, Linton MF, Farese RV
J Clin Invest. 2001
PubMed ID: 11160132
RefSeq and LocusLink: NCBI gene-centered resources.
Pruitt KD, Maglott DR
Nucleic Acids Res. 2001
PubMed ID: 11125071
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross.
Patel NV, Hitzemann RJ
Behav Genet. 1999
PubMed ID: 10765558
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Ko MS, Threat TA, Wang X, Horton JH, Cui Y, Wang X, Pryor E, Paris J, Wells-Smith J, Kitchen JR, Rowe LB, Eppig J, Satoh T, Brant L, Fujiwara H, Yotsumoto S, Nakashima H
Hum Mol Genet. 1998
PubMed ID: 9811942
Mitochondrial acetoacetyl-CoA thiolase (beta-ketothiolase) deficiency and pregnancy.
Sewell AC, Herwig J, Wiegratz I, Lehnert W, Niederhoff H, Song XQ, Kondo N, Fukao T
J Inherit Metab Dis. 1998
PubMed ID: 9700610
Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.
Mehrabian M, Wen PZ, Fisler J, Davis RC, Lusis AJ
J Clin Invest. 1998
PubMed ID: 9616220
Characterization of N93S, I312T, and A333P missense mutations in two Japanese families with mitochondrial acetoacetyl-CoA thiolase deficiency.
Fukao T, Nakamura H, Song XQ, Nakamura K, Orii KE, Kohno Y, Kano M, Yamaguchi S, Hashimoto T, Orii T, Kondo N
Hum Mutat. 1998
PubMed ID: 9744475
Practical assay method of cytosolic acetoacetyl-CoA thiolase by rapid release of cytosolic enzymes from cultured lymphocytes using digitonin.
Watanabe H, Yamaguchi S, Kimura M, Wakazono A, Song XQ, Fukao T, Orii T, Hashimoto T
Tohoku J Exp Med. 1998
PubMed ID: 9607396
Enzymes of ketone body utilization in human tissues: protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases.
Fukao T, Song XQ, Mitchell GA, Yamaguchi S, Sukegawa K, Orii T, Kondo N
Pediatr Res. 1997
PubMed ID: 9380443
Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene.
Schweifer N, Valk PJ, Delwel R, Cox R, Francis F, Meier-Ewert S, Lehrach H, Barlow DP
Genomics. 1997
PubMed ID: 9268631
Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9.
Xia Y, Welch CL, Warden CH, Lange E, Fukao T, Lusis AJ, Gatti RA
Mamm Genome. 1996
PubMed ID: 8672141
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Pecker I, Avraham KB, Gilbert DJ, Savitsky K, Rotman G, Harnik R, Fukao T, Schröck E, Hirotsune S, Tagle DA, Collins FS, Wynshaw-Boris A, Ried T, Copeland NG, Jenkins NA, Shiloh Y, Ziv Y
Genomics. 1996
PubMed ID: 8661102
Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster.
Matsuda Y, Imai T, Shiomi T, Saito T, Yamauchi M, Fukao T, Akao Y, Seki N, Ito H, Hori TA
Genomics. 1996
PubMed ID: 8786135
Tissue-specific expression and cholesterol regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) in mice. Molecular cloning of mouse ACAT cDNA, chromosomal localization, and regulation of ACAT in vivo and in vitro.
Uelmen PJ, Oka K, Sullivan M, Chang CC, Chang TY, Chan L
J Biol Chem. 1995
PubMed ID: 7592824
DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype.
Nerurkar PV, Schut HA, Anderson LM, Riggs CW, Snyderwine EG, Thorgeirsson SS, Weber WW, Rice JM, Levy GN
Cancer Res. 1995
PubMed ID: 7606725
Thyroid hormones regulate development of energy metabolism enzymes in rat proximal convoluted tubule.
Wijkhuisen A, Djouadi F, Vilar J, Merlet-Benichou C, Bastin J
Am J Physiol. 1995
PubMed ID: 7733320
Prenatal diagnosis in a family with mitochondrial acetoacetyl-coenzyme A thiolase deficiency with the use of the polymerase chain reaction followed by the heteroduplex detection method.
Fukao T, Wakazono A, Song XQ, Yamaguchi S, Zacharias R, Donlan MA, Orii T
Prenat Diagn. 1995
PubMed ID: 7617578
Molecular basis of beta-ketothiolase deficiency: mutations and polymorphisms in the human mitochondrial acetoacetyl-coenzyme A thiolase gene.
Fukao T, Yamaguchi S, Orii T, Hashimoto T
Hum Mutat. 1995
PubMed ID: 7749408
Molecular, biochemical, and clinical characterization of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in two further patients.
Wakazono A, Fukao T, Yamaguchi S, Hori T, Orii T, Lambert M, Mitchell GA, Lee GW, Hashimoto T
Hum Mutat. 1995
PubMed ID: 7728148
Identification of a novel exonic mutation at -13 from 5' splice site causing exon skipping in a girl with mitochondrial acetoacetyl-coenzyme A thiolase deficiency.
Fukao T, Yamaguchi S, Wakazono A, Orii T, Hoganson G, Hashimoto T
J Clin Invest. 1994
PubMed ID: 7907600
Analysis of pyruvate dehydrogenase expression in embryonic mouse brain: localization and developmental regulation.
Takakubo F, Dahl HH
Brain Res Dev Brain Res. 1994
PubMed ID: 7510589
Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17.
Himmelbauer H, Artzt K, Barlow D, Fischer-Lindahl K, Lyon M, Klein J, Silver LM
Mamm Genome. 1993
PubMed ID: 8268678
Molecular studies of mitochondrial acetoacetyl-coenzyme A thiolase deficiency in the two original families.
Fukao T, Yamaguchi S, Scriver CR, Dunbar G, Wakazono A, Kano M, Orii T, Hashimoto T
Hum Mutat. 1993
PubMed ID: 8103405
Molecular basis of 3-ketothiolase deficiency: identification of an AG to AC substitution at the splice acceptor site of intron 10 causing exon 11 skipping.
Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T
Biochim Biophys Acta. 1992
PubMed ID: 1627655
Identification of three mutant alleles of the gene for mitochondrial acetoacetyl-coenzyme A thiolase. A complete analysis of two generations of a family with 3-ketothiolase deficiency.
Fukao T, Yamaguchi S, Orii T, Schutgens RB, Osumi T, Hashimoto T
J Clin Invest. 1992
PubMed ID: 1346617
Chromosome mapping of the human mitochondrial acetoacetyl-coenzyme A thiolase gene to 11q22.3----q23.1 by fluorescence in situ hybridization.
Masuno M, Kano M, Fukao T, Yamaguchi S, Osumi T, Hashimoto T, Takahashi E, Hori T, Orii T
Cytogenet Cell Genet. 1992
PubMed ID: 1351831
Structure and expression of the human mitochondrial acetoacetyl-CoA thiolase-encoding gene.
Kano M, Fukao T, Yamaguchi S, Orii T, Osumi T, Hashimoto T
Gene. 1991
PubMed ID: 1684944
Identification of the CoA-modified forms of mitochondrial acetyl-CoA acetyltransferase and of glutamate dehydrogenase as nearest-neighbour proteins.
Schwerdt G, Möller U, Huth W
Biochem J. 1991
PubMed ID: 1684101
Evidence for a structural mutation (347Ala to Thr) in a German family with 3-ketothiolase deficiency.
Fukao T, Yamaguchi S, Tomatsu S, Orii T, Frauendienst-Egger G, Schrod L, Osumi T, Hashimoto T
Biochem Biophys Res Commun. 1991
PubMed ID: 1715688
Evidence for an in vivo modification of mitochondrial proteins by coenzyme A.
Huth W, Worm-Breitgoff C, Möller U, Wunderlich I
Biochim Biophys Acta. 1991
PubMed ID: 1672610
Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.
Fukao T, Yamaguchi S, Kano M, Orii T, Fujiki Y, Osumi T, Hashimoto T
J Clin Invest. 1990
PubMed ID: 1979337
Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase.
Fukao T, Kamijo K, Osumi T, Fujiki Y, Yamaguchi S, Orii T, Hashimoto T
J Biochem. 1989
PubMed ID: 2478525
Isolation and characterization of cDNA clones from mouse skeletal muscle actin mRNA.
Leader DP, Gall I, Campbell P, Frischauf AM
DNA. 1986
PubMed ID: 3013550
3-Ketothiolase deficiency.
Middleton B, Bartlett K, Romanos A, Gomez Vazquez J, Conde C, Cannon RA, Lipson M, Sweetman L, Nyhan WL
Eur J Pediatr. 1986
PubMed ID: 3709573
Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development.
Williamson DH, Ilic V
Biochem J. 1985
PubMed ID: 2866764
Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life.
Escrivá F, Rodríguez C, Pascual-Leone AM
J Neurochem. 1985
PubMed ID: 2985752
Biosynthesis of enzymes of rat-liver mitochondrial beta-oxidation.
Ozasa H, Furuta S, Miyazawa S, Osumi T, Hashimoto T, Mori M, Miura S, Tatibana M
Eur J Biochem. 1984
PubMed ID: 6489337
Circulating glucose, insulin and ketone bodies and enzymes of ketone body utilization in brain mitochondria from suckling rats treated with high L-thyroxine doses.
Escrivá F, Pascual-Leone AM, Galán A, Encinas JP
Rev Esp Fisiol. 1983
PubMed ID: 6144148
Beta-ketothiolase deficiency in a family confirmed by in vitro enzymatic assays in fibroblasts.
Schutgens RB, Middleton B, vd Blij JF, Oorthuys JW, Veder HA, Vulsma T, Tegelaers WH
Eur J Pediatr. 1982
PubMed ID: 7173255
[Various roentgenomorphological parallels in ulcers of the pyloro-duodenal area].
Sokolov IuN, Kaigorodtseva RN, Rudykh VF
Vestn Rentgenol Radiol. 1978
PubMed ID: 734884
[A rare type of bone involvement in scleroderma (author's transl)]
Bem Z, Birecka A
Pol Przegl Radiol Med Nukl. 1978
PubMed ID: 704385
The acetoacetyl-coenzyme A thiolases of rat brain and their relative activities during postnatal development.
Middleton B
Biochem J. 1973
PubMed ID: 4721608
An inherited disorder of isoleucine catabolism causing accumulation of alpha-methylacetoacetate and alpha-methyl-beta -hydroxybutyrate, and intermittent metabolic acidosis.
Daum RS, Scriver CR, Mamer OA, Delvin E, Lamm P, Goldman H
Pediatr Res. 1973
PubMed ID: 4690360
The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat.
Lockwood EA, Bailey E
Biochem J. 1971
PubMed ID: 5166591

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	38	110446	25014
EnsEMBL Gene(s)	ENSG00000075239	ENSMUSG00000032047	ENSRNOG00000007862
Unigene	Hs.232375	Mm.293233	Rn.4054
Homologene	ACAT1	Acat1	Acat1
OMIM	607809	N/A	N/A
GeneCards	ACAT1	N/A	N/A
Beta Cell Genomics	DT.100014180 DT.40305180 DT.95082281	DT.102558494 DT.87069871 DT.94299926	N/A
Reactome	P24752	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	38	110446	25014

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