CD82

Summary Top Help

Gene Description:

CD82 antigen; Cd82 molecule; CD82 molecule

Synonyms:

SAR2, TSPAN27, GR15, 4F9, C33, Kai1, ST6, AL023070, IA4, Tspan27, CD82, AA682076, KAI1, R2, Cd82

Orthologs:

Human CD82 (protein-coding), Mouse Cd82 (protein-coding), Rat Cd82 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:44585977..44641913 (55.94 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:93259268..93303297 (443 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:77831771..77875764 (43.99 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for CD82:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for CD82:

The CD82 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
CD82	HBEGF	HPRD, BioGRID	empirical	10749879
CD82	EGFR	HPRD, BioGRID	empirical	10985391
CD82	ERBB2	HPRD, BioGRID	empirical	14576349
CD82	ERBB3	HPRD, BioGRID	empirical	14576349
CD82	HLA-DMA	HPRD	empirical	9759843
CD82	HLA-DMB	HPRD, BioGRID	empirical	9759843
CD82	HLA-DOB	BioGRID	empirical	9759843
CD82	HLA-DRA	HPRD, BioGRID	empirical	9759843
CD82	ITGA6	HPRD	empirical	8757325
CD82	ITGA3	HPRD	empirical	8757325
CD82	ITGA4	HPRD	empirical	8757325
CD82	ITGAL	BioGRID	empirical	10602019
CD82	ITGB2	HPRD	empirical	10602019
CD82	LRP1	HPRD	empirical	9804823
CD82	CD46	BioGRID	empirical	10741407
CD82	NUP88	HPRD, MINT, IntAct	empirical	16169070
CD82	PTGFRN	HPRD, BioGRID	empirical	11278880
CD82	UBC	BioGRID	empirical	21906983
CD82	VANGL1	HPRD, IntAct	empirical	15205336
CD82	CANX	HPRD	empirical	11350933
CD82	CD4	HPRD, BioGRID	empirical	7636191
CD82	CD9	BioGRID	empirical	15492270
CD82	CD19	HPRD, BioGRID	empirical	9804823 7636191
CD82	IGSF8	HPRD, BioGRID	empirical	12750295
CD82	CD63	HPRD, BioGRID	empirical	9759843
CD82	CD151	BioGRID	empirical	15492270

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 3

Publications from PubMed Top Help

Publications: 144

Tetraspanins regulate the protrusive activities of cell membrane.
Bari R, Guo Q, Xia B, Zhang YH, Giesert EE, Levy S, Zheng JJ, Zhang XA
Biochem Biophys Res Commun. 2011
PubMed ID: 22079629
Dissecting the diverse functions of the metastasis suppressor CD82/KAI1.
Tsai YC, Weissman AM
FEBS Lett. 2011
PubMed ID: 21875585
Expression of thymidylate synthase and dihydropyrimidine dehydrogenase in primary oral squamous cell carcinoma and corresponding metastases in cervical lymph nodes: association with the metastasis suppressor CD82.
Kawasaki G, Yoshitomi I, Yanamoto S, Yamada S, Mizuno A, Umeda M
Anticancer Res. 2011
PubMed ID: 21965773
CD82 gene suppression in endometrial stromal cells leads to increase of the cell invasiveness in the endometriotic milieu.
Li MQ, Hou XF, Lv SJ, Meng YH, Wang XQ, Tang CL, Li DJ
J Mol Endocrinol. 2011
PubMed ID: 21685244
KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.
Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai SK, Pandey PR, Xing F, Fukuda K, Modur V, Hirota S, Suzuki K, Chiba T, Endo M, Sugai T, Watabe K
J Biol Chem. 2011
PubMed ID: 21454613
KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity.
Liu X, Guo XZ, Zhang WW, Lu ZZ, Zhang QW, Duan HF, Wang LS
Hepatobiliary Pancreat Dis Int. 2011
PubMed ID: 21459729
HIF-2 directly activates CD82 gene expression in endothelial cells.
Nagao K, Oka K
Biochem Biophys Res Commun. 2011
PubMed ID: 21382346
The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification.
Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL, Vyas JM
Infect Immun. 2011
PubMed ID: 21149584
Overexpression of KAI1 induces autophagy and increases MiaPaCa-2 cell survival through the phosphorylation of extracellular signal-regulated kinases.
Wu CY, Yan J, Yang YF, Xiao FJ, Li QF, Zhang QW, Wang LS, Guo XZ, Wang H
Biochem Biophys Res Commun. 2011
PubMed ID: 21168384
Metastasis suppressor KAI1/CD82 attenuates the matrix adhesion of human prostate cancer cells by suppressing fibronectin expression and β1 integrin activation.
Lee HA, Park I, Byun HJ, Jeoung D, Kim YM, Lee H
Cell Physiol Biochem. 2011
PubMed ID: 21691075
Down-regulation of TM4SF is associated with the metastatic potential of gastric carcinoma TM4SF members in gastric carcinoma.
Chen Z, Gu S, Trojanowicz B, Liu N, Zhu G, Dralle H, Hoang-Vu C
World J Surg Oncol. 2011
PubMed ID: 21521534
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
The DSCs-expressed CD82 controls the invasiveness of trophoblast cells via integrinbeta1/MAPK/MAPK3/1 signaling pathway in human first-trimester pregnancy.
Li MQ, Hou XF, Shao J, Tang CL, Li DJ
Biol Reprod. 2010
PubMed ID: 20075392
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.
Joshi B, Li L, Nabi IR
J Biol Chem. 2010
PubMed ID: 20089858
Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling.
Danglot L, Chaineau M, Dahan M, Gendron MC, Boggetto N, Perez F, Galli T
J Cell Sci. 2010
PubMed ID: 20144992
Identification of the KAI1 metastasis suppressor gene as a hypoxia target gene.
Kim B, Boo K, Lee JS, Kim KI, Kim WH, Cho HJ, Park YB, Kim HS, Baek SH
Biochem Biophys Res Commun. 2010
PubMed ID: 20123085
Identifying CD82 (KAI1) as a marker for human chromophobe renal cell carcinoma.
Yusenko MV, Kovacs G
Histopathology. 2009
PubMed ID: 20002769
Expression of nm23, KAI1 and spiral computed tomography findings in primary gallbladder carcinoma.
Jiang WX, Song BG, Wang PJ
Chin Med J (Engl). 2009
PubMed ID: 19951590
Tetraspanin-induced death of myeloma cell lines is autophagic and involves increased UPR signalling.
Zismanov V, Lishner M, Tartakover-Matalon S, Radnay J, Shapiro H, Drucker L
Br J Cancer. 2009
PubMed ID: 19755988
CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.
Xu C, Zhang YH, Thangavel M, Richardson MM, Liu L, Zhou B, Zheng Y, Ostrom RS, Zhang XA
FASEB J. 2009
PubMed ID: 19497983
The tetraspanin KAI1/CD82 is expressed by late-lineage oligodendrocyte precursors and may function to restrict precursor migration and promote oligodendrocyte differentiation and myelination.
Mela A, Goldman JE
J Neurosci. 2009
PubMed ID: 19741124
Expression of KAI1/CD82 in distant metastases from estrogen receptor-negative breast cancer.
Christgen M, Christgen H, Heil C, Krech T, Länger F, Kreipe H, Lehmann U
Cancer Sci. 2009
PubMed ID: 19549254
Control of cell motility by interaction of gangliosides, tetraspanins, and epidermal growth factor receptor in A431 versus KB epidermoid tumor cells.
Park SY, Yoon SJ, Freire-de-Lima L, Kim JH, Hakomori SI
Carbohydr Res. 2009
PubMed ID: 19559406
The mouse C2C12 myoblast cell surface N-linked glycoproteome: Identification, glycosite occupancy, and membrane orientation.
Gundry RL, Raginski K, Tarasova Y, Tchernyshyov I, Bausch-Fluck D, Elliott ST, Boheler KR, Van Eyk JE, Wollscheid B
Mol Cell Proteomics. 2009
PubMed ID: 19656770
Expression and clinical significance of p53, JunB and KAI1/CD82 in human hepatocellular carcinoma.
Guo C, Liu QG, Zhang L, Song T, Yang X
Hepatobiliary Pancreat Dis Int. 2009
PubMed ID: 19666408
Effect of expressional alteration of KAI1 on breast cancer cell growth, adhesion, migration and invasion.
Malik FA, Sanders AJ, Kayani MA, Jiang WG
Cancer Genomics Proteomics. 2009
PubMed ID: 19656997
Tumor suppressor KAI1 affects integrin alphavbeta3-mediated ovarian cancer cell adhesion, motility, and proliferation.
Ruseva Z, Geiger PX, Hutzler P, Kotzsch M, Luber B, Schmitt M, Gross E, Reuning U
Exp Cell Res. 2009
PubMed ID: 19371633
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
Nat Biotechnol. 2009
PubMed ID: 19349973
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
Transcriptional and translational modulation of KAI1 expression in ductal carcinoma of the breast and the prognostic significance.
Malik FA, Sanders AJ, Jones AD, Mansel RE, Jiang WG
Int J Mol Med. 2009
PubMed ID: 19148553
Transmembrane interactions are needed for KAI1/CD82-mediated suppression of cancer invasion and metastasis.
Bari R, Zhang YH, Zhang F, Wang NX, Stipp CS, Zheng JJ, Zhang XA
Am J Pathol. 2009
PubMed ID: 19116362
Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours.
Yusenko MV, Zubakov D, Kovacs G
Int J Biol Sci. 2009
PubMed ID: 19680475
[Role of KAI1 gene expression and loss of heterozygosity of KAI1 in metastatic potential and prognosis of pancreatic cancer].
Fan LX, Shen L, Li JY, Pan KF, Dong B, Zhang Y
Zhonghua Bing Li Xue Za Zhi. 2009
PubMed ID: 19489224
KAI1/CD82 decreases Rac1 expression and cell proliferation through PI3K/Akt/mTOR pathway in H1299 lung carcinoma cells.
Choi UJ, Jee BK, Lim Y, Lee KH
Cell Biochem Funct. 2009
PubMed ID: 19107873
Decreased expression of KAI1/CD82 metastasis suppressor gene is associated with loss of heterozygosity in melanoma cell lines.
Kim YI, Shin MK, Lee JW, Chung JH, Lee MH
Oncol Rep. 2009
PubMed ID: 19082457
Phorbol ester enhances KAI1 transcription by recruiting Tip60/Pontin complexes.
Rowe A, Weiske J, Kramer TS, Huber O, Jackson P
Neoplasia. 2008
PubMed ID: 19048121
Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor.
Arduise C, Abache T, Li L, Billard M, Chabanon A, Ludwig A, Mauduit P, Boucheix C, Rubinstein E, Le Naour F
J Immunol. 2008
PubMed ID: 18981120
KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer.
Christgen M, Bruchhardt H, Ballmaier M, Krech T, Länger F, Kreipe H, Lehmann U
Int J Cancer. 2008
PubMed ID: 18712725
KAI1/CD82 suppresses hepatocyte growth factor-induced migration of hepatoma cells via upregulation of Sprouty2.
Mu Z, Wang H, Zhang J, Li Q, Wang L, Guo X
Sci China C Life Sci. 2008
PubMed ID: 18622748
Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas.
Briese J, Schulte HM, Sajin M, Bamberger C, Redlin K, Milde-Langosch K, Löning T, Bamberger AM
Virchows Arch. 2008
PubMed ID: 18415123
[Expression of nm23 and KAI1 and their clinical significance in gallbladder adenocarcinoma]
Jiang WX, Song BG, Tang RY, Fang JP
Zhonghua Zhong Liu Za Zhi. 2008
PubMed ID: 19024519
Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma.
Protzel C, Kakies C, Kleist B, Poetsch M, Giebel J
Virchows Arch. 2008
PubMed ID: 18305955
Broadening of transgenic adenocarcinoma of the mouse prostate (TRAMP) model to represent late stage androgen depletion independent cancer.
Jeet V, Ow K, Doherty E, Curley B, Russell PJ, Khatri A
Prostate. 2008
PubMed ID: 18247402
Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway.
Todeschini AR, Dos Santos JN, Handa K, Hakomori SI
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18272501
KAI1 gene suppresses invasion and metastasis of hepatocellular carcinoma MHCC97-H cells in vitro and in animal models.
Yang JM, Peng ZH, Si SH, Liu WW, Luo YH, Ye ZY
Liver Int. 2008
PubMed ID: 18028322
The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.
Tsai YC, Mendoza A, Mariano JM, Zhou M, Kostova Z, Chen B, Veenstra T, Hewitt SM, Helman LJ, Khanna C, Weissman AM
Nat Med. 2007
PubMed ID: 18037895
An alternatively spliced KAI1 mRNA is expressed at low levels in human bladder cancers and bladder cancer cell lines and is not associated with invasive behaviour.
Jackson P, Rowe A, Grimm MO
Oncol Rep. 2007
PubMed ID: 17982617
Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration.
Takahashi M, Sugiura T, Abe M, Ishii K, Shirasuna K
Int J Cancer. 2007
PubMed ID: 17621632
Effect of KAI1/CD82 on the beta1 integrin maturation in highly migratory carcinoma cells.
Jee BK, Lee JY, Lim Y, Lee KH, Jo YH
Biochem Biophys Res Commun. 2007
PubMed ID: 17560548
Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells.
Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL
J Immunol. 2007
PubMed ID: 17513769
[Effect of metastasis suppressor gene KAI1 on adhesion of hepatocellular carcinoma cell line MHCC97-H]
Yu Y, Han DE, Liu W
Ai Zheng. 2007
PubMed ID: 17672940
[In situ hybridization study on the expression of Kiss-1 and KAI-1 metastasis suppressor genes in gastric cancer]
Yao HL, Yang ZL, Li YG, Liu GW
Zhonghua Wei Chang Wai Ke Za Zhi. 2007
PubMed ID: 17520389
Protein networking in bladder cancer: immunoreactivity for FGFR3, EGFR, ERBB2, KAI1, PTEN, and RAS in normal and malignant urothelium.
Røtterud R, Fosså SD, Nesland JM
Histol Histopathol. 2007
PubMed ID: 17290345
Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse.
Todeschini AR, Dos Santos JN, Handa K, Hakomori SI
J Biol Chem. 2007
PubMed ID: 17215249
The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein.
Mazurov D, Heidecker G, Derse D
J Biol Chem. 2007
PubMed ID: 17166843
Expression of KAI1/CD82 and MRP-1/CD9 in transitional cell carcinoma of bladder.
Ai X, Zhang X, Wu Z, Ma X, Ju Z, Wang B, Shi T
J Huazhong Univ Sci Technolog Med Sci. 2007
PubMed ID: 17393117
Expression of the metastasis suppressor KAI1 in decidual cells at the human maternal-fetal interface: Regulation and functional implications.
Gellersen B, Briese J, Oberndörfer M, Redlin K, Samalecos A, Richter DU, Löning T, Schulte HM, Bamberger AM
Am J Pathol. 2007
PubMed ID: 17200188
[Relationship between the expressions of KaI1, nm23, ETS-1, VEGF and microvascular density and clinical significance in nasopharyngeal carcinoma].
He SQ, Zhang WY
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2006
PubMed ID: 17283532
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochem Biophys Res Commun. 2006
PubMed ID: 16712791
A novel link between SUMO modification and cancer metastasis.
Baek SH
Cell Cycle. 2006
PubMed ID: 16861889
Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1.
Nydegger S, Khurana S, Krementsov DN, Foti M, Thali M
J Cell Biol. 2006
PubMed ID: 16735575
Characterization of an antibody that can detect the Kai1/CD82 murine metastasis suppressor.
Custer MC, Risinger JI, Hoover S, Simpson RM, Patterson T, Barrett JC
Prostate. 2006
PubMed ID: 16372335
KAI1/CD82 suppresses tumor invasion by MMP9 inactivation via TIMP1 up-regulation in the H1299 human lung carcinoma cell line.
Jee BK, Park KM, Surendran S, Lee WK, Han CW, Kim YS, Lim Y
Biochem Biophys Res Commun. 2006
PubMed ID: 16488391
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
HTLV-1 Gag protein associates with CD82 tetraspanin microdomains at the plasma membrane.
Mazurov D, Heidecker G, Derse D
Virology. 2006
PubMed ID: 16325219
[Expression and clinical value of KAI1/CD82 in carcinoma of larynx].
Shu Y, Chen H, Tan Y
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005
PubMed ID: 16494006
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk.
Higashiyama S, Nanba D
Biochim Biophys Acta. 2005
PubMed ID: 16054021
Aberrant expression of novel and previously described cell membrane markers in human breast cancer cell lines and tumors.
Huang H, Groth J, Sossey-Alaoui K, Hawthorn L, Beall S, Geradts J
Clin Cancer Res. 2005
PubMed ID: 15958618
[Expression of KAI1 gene in human laryngeal carcinoma and its clinical significance]
Bai WL, Ren Z, Pan ZM, Gao H
Zhonghua Zhong Liu Za Zhi. 2005
PubMed ID: 15996322
Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.
Bass R, Werner F, Odintsova E, Sugiura T, Berditchevski F, Ellis V
J Biol Chem. 2005
PubMed ID: 15677461
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes.
Kim JH, Kim B, Cai L, Choi HJ, Ohgi KA, Tran C, Chen C, Chung CH, Huber O, Rose DW, Sawyers CL, Rosenfeld MG, Baek SH
Nature. 2005
PubMed ID: 15829968
Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.
Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, Sikela JM, Williams RW, Miles MF
J Neurosci. 2005
PubMed ID: 15745951
Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases.
Stark AM, Tongers K, Maass N, Mehdorn HM, Held-Feindt J
J Cancer Res Clin Oncol. 2005
PubMed ID: 15592684
Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion.
He B, Liu L, Cook GA, Grgurevich S, Jennings LK, Zhang XA
J Biol Chem. 2005
PubMed ID: 15557282
[Expression of metastasis suppressor gene KAI1/CD82 in cervical squamous cell carcinoma and its clinical significance].
Xiong Y, Liang LZ, Yan XJ, Yuan SH, Wei M
Ai Zheng. 2005
PubMed ID: 15642213
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity.
Zhou B, Liu L, Reddivari M, Zhang XA
Cancer Res. 2004
PubMed ID: 15492270
Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation.
Delaguillaumie A, Harriague J, Kohanna S, Bismuth G, Rubinstein E, Seigneuret M, Conjeaud H
J Cell Sci. 2004
PubMed ID: 15454569
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
CD82, and CD63 in thyroid cancer.
Chen Z, Mustafa T, Trojanowicz B, Brauckhoff M, Gimm O, Schmutzler C, Köhrle J, Holzhausen HJ, Kehlen A, Klonisch T, Finke R, Dralle H, Hoang-Vu C
Int J Mol Med. 2004
PubMed ID: 15375577
Temporal changes in gene expression after injury in the rat retina.
Vázquez-Chona F, Song BK, Geisert EE
Invest Ophthalmol Vis Sci. 2004
PubMed ID: 15277499
KAI1 gene expression in colonic carcinoma and its clinical significances.
Wu DH, Liu L, Chen LH, Ding YQ
World J Gastroenterol. 2004
PubMed ID: 15259074
Effects of KAI1 gene on growth and invasion of human hepatocellular carcinoma MHCC97-H cells.
Si SH, Yang JM, Peng ZH, Luo YH, Zhou P
World J Gastroenterol. 2004
PubMed ID: 15237426
KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer.
Lee JH, Park SR, Chay KO, Seo YW, Kook H, Ahn KY, Kim YJ, Kim KK
Cancer Res. 2004
PubMed ID: 15205336
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Decreased expression of KAI1 metastasis suppressor gene is a recurrence predictor in primary pTa and pT1 urothelial bladder carcinoma.
Su JS, Arima K, Hasegawa M, Franco OE, Umeda Y, Yanagawa M, Sugimura Y, Kawamura J
Int J Urol. 2004
PubMed ID: 14706010
Tetraspanin CD82 regulates compartmentalisation and ligand-induced dimerization of EGFR.
Odintsova E, Voortman J, Gilbert E, Berditchevski F
J Cell Sci. 2003
PubMed ID: 14576349
Role of tumor metastasis suppressor gene KAI1 in digestive tract carcinomas and cancer cells.
Wu Q, Ji Y, Zhang MQ, Chen YQ, Chen F, Shi DL, Zheng ZH, Huang YJ, Su WJ
Cell Tissue Res. 2003
PubMed ID: 12955496
Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration.
Zhang XA, He B, Zhou B, Liu L
J Biol Chem. 2003
PubMed ID: 12738793
EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.
Zhang XA, Lane WS, Charrin S, Rubinstein E, Liu L
Cancer Res. 2003
PubMed ID: 12750295
[Role of tumor metastasis suppressor gene KAI1 in development of colorectal cancer]
Yang J, Liu FX, Yan XC, He GY, Liu LM
Ai Zheng. 2003
PubMed ID: 12753720
KAI1 metastasis suppressor protein is down-regulated during the progression of human endometrial cancer.
Liu FS, Dong JT, Chen JT, Hsieh YT, Ho ES, Hung MJ, Lu CH, Chiou LC
Clin Cancer Res. 2003
PubMed ID: 12684410
Expression of tetraspanin adaptor proteins below defined threshold values is associated with in vitro invasiveness of mammary carcinoma cells.
Sauer G, Kurzeder C, Grundmann R, Kreienberg R, Zeillinger R, Deissler H
Oncol Rep. 2003
PubMed ID: 12579280
Metastasis-suppressor KAI1/CD82 induces homotypic aggregation of human prostate cancer cells through Src-dependent pathway.
Jee B, Jin K, Hahn JH, Song HG, Lee H
Exp Mol Med. 2003
PubMed ID: 12642901
Downregulation of KAI1 mRNA in localised prostate cancer and its bony metastases does not correlate with p53 overexpression.
Jackson P, Ow K, Yardley G, Delprado W, Quinn DI, Yang JL, Russell PJ
Prostate Cancer Prostatic Dis. 2003
PubMed ID: 12806379
KAI1 expression in thyroid neoplasms: its linkage with clinicopathologic features in papillary carcinoma.
Ito Y, Yoshida H, Uruno T, Nakano K, Takamura Y, Miya A, Kobayashi K, Yokozawa T, Matsuzuka F, Kuma K, Miyauchi A
Pathol Res Pract. 2003
PubMed ID: 12747469
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression.
Houle CD, Ding XY, Foley JF, Afshari CA, Barrett JC, Davis BJ
Gynecol Oncol. 2002
PubMed ID: 12079303
Relationship between expression of KAI1 metastasis suppressor gene, mRNA levels and p53 in human bladder and prostate cancer cell lines.
Jackson P, Grimm MO, Kingsley EA, Brosius U, Antalis T, Yardley G, Russell PJ
Urol Oncol. 2002
PubMed ID: 12474542
Distinctive signaling pathways through CD82 and beta1 integrins in human T cells.
Iwata S, Kobayashi H, Miyake-Nishijima R, Sasaki T, Souta-Kuribara A, Nori M, Hosono O, Kawasaki H, Tanaka H, Morimoto C
Eur J Immunol. 2002
PubMed ID: 11981820
High prevalence of decreased expression of KAI1 metastasis suppressor in human oral carcinogenesis.
Uzawa K, Ono K, Suzuki H, Tanaka C, Yakushiji T, Yamamoto N, Yokoe H, Tanzawa H
Clin Cancer Res. 2002
PubMed ID: 11895916
Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.
Delaguillaumie A, Lagaudrière-Gesbert C, Popoff MR, Conjeaud H
J Cell Sci. 2002
PubMed ID: 11839793
Quality control of transmembrane domain assembly in the tetraspanin CD82.
Cannon KS, Cresswell P
EMBO J. 2001
PubMed ID: 11350933
The major CD9 and CD81 molecular partner. Identification and characterization of the complexes.
Charrin S, Le Naour F, Oualid M, Billard M, Faure G, Hanash SM, Boucheix C, Rubinstein E
J Biol Chem. 2001
PubMed ID: 11278880
Establishment of rat hepatocellular carcinoma cell lines with differing metastatic potential in nude mice.
Ogawa K, Nakanishi H, Takeshita F, Futakuchi M, Asamoto M, Imaida K, Tatematsu M, Shirai T
Int J Cancer. 2001
PubMed ID: 11275982
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
KAI1 expression can be a predictor of stage A prostate cancer progression.
Tozawa K, Akita H, Kawai N, Okamura T, Sasaki S, Hayashi Y, Kohri K
Prostate Cancer Prostatic Dis. 2001
PubMed ID: 12497033
Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells.
Ono M, Handa K, Withers DA, Hakomori S
Biochem Biophys Res Commun. 2000
PubMed ID: 11162423
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.
Szpirer C, Van Vooren P, Rivière M, Scohy S, Collau G, Szpirer J
Mamm Genome. 2000
PubMed ID: 10967130
Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1.
Odintsova E, Sugiura T, Berditchevski F
Curr Biol. 2000
PubMed ID: 10985391
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity.
Nakamura K, Mitamura T, Takahashi T, Kobayashi T, Mekada E
J Biol Chem. 2000
PubMed ID: 10749879
CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.
Lozahic S, Christiansen D, Manié S, Gerlier D, Billard M, Boucheix C, Rubinstein E
Eur J Immunol. 2000
PubMed ID: 10741407
Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation.
Shibagaki N, Hanada K, Yamashita H, Shimada S, Hamada H
Eur J Immunol. 1999
PubMed ID: 10602019
Loss of KAI1 expression in the progression of colorectal cancer.
Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC
Cancer Res. 1999
PubMed ID: 10582691
Frequent loss of KAI1 expression in squamous and lymphoid neoplasms. An immunohistochemical study of archival tissues.
Geradts J, Maynard R, Birrer MJ, Hendricks D, Abbondanzo SL, Fong KM, Barrett JC, Lombardi DP
Am J Pathol. 1999
PubMed ID: 10362791
Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E
Biochem J. 1999
PubMed ID: 10229664
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Identification of the rat homologue of KAI1 and its expression in Dunning rat prostate cancers.
Suzuki H, Dong JT, Gao AC, Barrett JC, Isaacs JT
Prostate. 1998
PubMed ID: 9831222
CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82.
Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E
J Biol Chem. 1998
PubMed ID: 9804823
Identification of upregulated genes in the thymus of spontaneously hypertensive rats by cDNA representational difference analysis.
Zhao XS, Li XB, Zhu YC, Wan DF, Yao T
Blood Press. 1998
PubMed ID: 10321446
The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P
J Immunol. 1998
PubMed ID: 9759843
Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
Genomic organization of the human KAI1 metastasis-suppressor gene.
Dong JT, Isaacs WB, Barrett JC, Isaacs JT
Genomics. 1997
PubMed ID: 9126478
Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY.
Szöllósi J, Horejsí V, Bene L, Angelisová P, Damjanovich S
J Immunol. 1996
PubMed ID: 8816400
Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29).
Mannion BA, Berditchevski F, Kraeft SK, Chen LB, Hemler ME
J Immunol. 1996
PubMed ID: 8757325
Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.
Harrison SM, Dunwoodie SL, Arkell RM, Lehrach H, Beddington RS
Development. 1995
PubMed ID: 7671812
Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.
Imai T, Kakizaki M, Nishimura M, Yoshie O
J Immunol. 1995
PubMed ID: 7636191
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.
Dong JT, Lamb PW, Rinker-Schaeffer CW, Vukanovic J, Ichikawa T, Isaacs JT, Barrett JC
Science. 1995
PubMed ID: 7754374
Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
Immunogenetics. 1995
PubMed ID: 7590978
Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression.
Nagira M, Imai T, Ishikawa I, Uwabe KI, Yoshie O
Cell Immunol. 1994
PubMed ID: 8039242
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63.
Imai T, Fukudome K, Takagi S, Nagira M, Furuse M, Fukuhara N, Nishimura M, Hinuma Y, Yoshie O
J Immunol. 1992
PubMed ID: 1401919
Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11.
Ichikawa T, Ichikawa Y, Dong J, Hawkins AL, Griffin CA, Isaacs WB, Oshimura M, Barrett JC, Isaacs JT
Cancer Res. 1992
PubMed ID: 1596907
Genetic factors and suppression of metastatic ability of prostatic cancer.
Ichikawa T, Ichikawa Y, Isaacs JT
Cancer Res. 1991
PubMed ID: 2065333
A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23.
Gaugitsch HW, Hofer E, Huber NE, Schnabl E, Baumruker T
Eur J Immunol. 1991
PubMed ID: 1842498

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	3732	12521	83628
EnsEMBL Gene(s)	ENSG00000085117	ENSMUSG00000027215	ENSRNOG00000000047
Unigene	Hs.527778	Mm.4261	Rn.3022
Homologene	CD82	Cd82	Cd82
OMIM	600623	N/A	N/A
GeneCards	CD82	N/A	N/A
Beta Cell Genomics	DT.100793427 DT.97844941	DT.101398209 DT.110693196 DT.535034	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	3732	12521	83628

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