IRS1

Summary Top Help

Gene Description:

insulin receptor substrate 1

Synonyms:

IRS-1, IRS1IRM, HIRS-1, IRS1, Irs1, G972R

Orthologs:

Human IRS1 (protein-coding), Mouse Irs1 (protein-coding), Rat Irs1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 2

Linkage Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd5.4	Mouse	chr1:77143053..147306684	70.16	502
Idd5.4a	Mouse	chr1:77143053..147306684	70.16	454

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:227596033..227664475 (68.44 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:82229676..82288014 (58.34 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:81585251..81638071 (52.82 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for IRS1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for IRS1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 5

Biocarta: 7

Reactome: 14

NCI-Nature Pathway Interaction Database: 10

Gene Ontology: 49

Positive regulation of mesenchymal cell proliferation	GO:0002053
Signal transducer activity	GO:0004871
Insulin-like growth factor-activated receptor activity	GO:0005010
Transmembrane receptor protein tyrosine kinase adaptor activity	GO:0005068
Protein kinase C binding	GO:0005080
Insulin receptor binding	GO:0005158
Insulin-like growth factor receptor binding	GO:0005159
Protein binding	GO:0005515
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Microsome	GO:0005792
Cytosol	GO:0005829
Plasma membrane	GO:0005886
Insulin receptor complex	GO:0005899
Caveola	GO:0005901
Signal transduction	GO:0007165
Transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169
Positive regulation of cell proliferation	GO:0008284
Insulin receptor signaling pathway	GO:0008286
Regulation of gene expression	GO:0010468
Positive regulation of glucose metabolic process	GO:0010907
Phosphatidylinositol 3-kinase cascade	GO:0014065
Lipid catabolic process	GO:0016042
Positive regulation of cell migration	GO:0030335
Mammary gland development	GO:0030879
Positive regulation of fatty acid beta-oxidation	GO:0032000
Response to insulin stimulus	GO:0032868
Cellular response to insulin stimulus	GO:0032869
Protein localization to nucleus	GO:0034504
SH2 domain binding	GO:0042169
Positive regulation of phosphorylation	GO:0042327
Glucose homeostasis	GO:0042593
Response to peptide hormone stimulus	GO:0043434
Protein kinase B signaling cascade	GO:0043491
Phosphatidylinositol 3-kinase binding	GO:0043548
Positive regulation of phosphatidylinositol 3-kinase activity	GO:0043552
Positive regulation of glycogen biosynthetic process	GO:0045725
Positive regulation of glucose import	GO:0046326
Negative regulation of insulin receptor signaling pathway	GO:0046627
Positive regulation of insulin receptor signaling pathway	GO:0046628
Negative regulation of insulin secretion	GO:0046676
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	GO:0046934
Insulin-like growth factor receptor signaling pathway	GO:0048009
Nerve growth factor receptor signaling pathway	GO:0048011
Phosphatidylinositol-mediated signaling	GO:0048015
Protein heterooligomerization	GO:0051291
JAK-STAT cascade involved in growth hormone signaling pathway	GO:0060397
Positive regulation of glucagon secretion	GO:0070094
Negative regulation of somatostatin secretion	GO:0090275

Publications from PubMed Top Help

Type 1 Diabetes Publications: 48

Genetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.
Xuan S, Szabolcs M, Cinti F, Perincheri S, Accili D, Efstratiadis A
J Biol Chem. 2010
PubMed ID: 20947509
Vitamin D(3) restores altered cholinergic and insulin receptor expression in the cerebral cortex and muscarinic M3 receptor expression in pancreatic islets of streptozotocin induced diabetic rats.
Kumar PT, Antony S, Nandhu MS, Sadanandan J, Naijil G, Paulose CS
J Nutr Biochem. 2010
PubMed ID: 20655720
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrè AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jørgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsø T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Bragi Walters G, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI, MAGIC investigators, GIANT Consortium
Nat Genet. 2010
PubMed ID: 20581827
Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population.
Pappa KI, Gazouli M, Economou K, Daskalakis G, Anastasiou E, Anagnou NP, Antsaklis A
Gynecol Endocrinol. 2010
PubMed ID: 20540670
Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents.
Georgia S, Hinault C, Kawamori D, Hu J, Meyer J, Kanji M, Bhushan A, Kulkarni RN
Diabetes. 2010
PubMed ID: 20103709
EXERCISE MAINTAINS EUGLYCEMIA IN ASSOCIATION WITH DECREASED ACTIVATION OF cJUN NH2-TERMINAL KINASE AND SERINE PHOSPHORYLATION OF IRS1 IN THE LIVER OF ZDF RATS.
Kiraly MA, Campbell JE, Park E, Bates HE, Yue JT, Rao V, Matthews SG, Bikopoulos G, Rozakis-Adcock M, Giacca A, Vranic M, Riddell MC
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19996384
No association of the IRS1 and PAX4 genes with type I diabetes.
Bergholdt R, Brorsson C, Boehm B, Morahan G, Pociot F, Type I Diabetes Genetics Consortium
Genes Immun. 2009
PubMed ID: 19956100
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
Rung J, Cauchi S, Albrechtsen A, Shen L, Rocheleau G, Cavalcanti-Proença C, Bacot F, Balkau B, Belisle A, Borch-Johnsen K, Charpentier G, Dina C, Durand E, Elliott P, Hadjadj S, Järvelin MR, Laitinen J, Lauritzen T, Marre M, Mazur A, Meyre D, Montpetit A, Pisinger C, Posner B, Poulsen P, Pouta A, Prentki M, Ribel-Madsen R, Ruokonen A, Sandbaek A, Serre D, Tichet J, Vaxillaire M, Wojtaszewski JF, Vaag A, Hansen T, Polychronakos C, Pedersen O, Froguel P, Sladek R
Nat Genet. 2009
PubMed ID: 19734900
Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.
Burguete-Garcia AI, Cruz-Lopez M, Madrid-Marina V, Lopez-Ridaura R, Hernández-Ávila M, Cortina B, Gómez RE, Velasco-Mondragón E
Metabolism. 2009
PubMed ID: 19716569
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate-2.
Assmann A, Ueki K, Winnay JN, Kulkarni RN
Mol Cell Biol. 2009
PubMed ID: 19273608
[Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatán, México]
García-Escalante MG, Suárez-Solís VM, López-Avila MT, Pinto-Escalante Ddel C, Laviada-Molina H
Invest Clin. 2009
PubMed ID: 19418728
Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.
Hribal ML, Tornei F, Pujol A, Menghini R, Barcaroli D, Lauro D, Amoruso R, Lauro R, Bosch F, Sesti G, Federici M
J Cell Mol Med. 2008
PubMed ID: 18208559
Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.
Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB
J Biol Chem. 2007
PubMed ID: 17545163
Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2.
Kawaguchi T, Ide T, Taniguchi E, Hirano E, Itou M, Sumie S, Nagao Y, Yanagimoto C, Hanada S, Koga H, Sata M
Am J Gastroenterol. 2007
PubMed ID: 17222321
Prolactin stimulates proliferation of the glucose-dependent beta-cell line INS-1 via different IRS-proteins.
Hügl SR, Merger M
JOP. 2007
PubMed ID: 17993726
Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T
J Clin Invest. 2007
PubMed ID: 17200721
Polymorphisms of insulin receptor substrate 1 and beta3-adrenergic receptor genes in gestational diabetes and normal pregnancy.
Fallucca F, Dalfrà MG, Sciullo E, Masin M, Buongiorno AM, Napoli A, Fedele D, Lapolla A
Metabolism. 2006
PubMed ID: 17046546
IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
Johansen A, Jensen DP, Bergholdt R, Mortensen HB, Pociot F, Nerup J, Hansen T, Pedersen O, Danish Society of Childhood Diabetes
Diabetes Obes Metab. 2006
PubMed ID: 16367885
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action.
Zhou H, Yamada Y, Tsukiyama K, Miyawaki K, Hosokawa M, Nagashima K, Toyoda K, Naitoh R, Mizunoya W, Fushiki T, Kadowaki T, Seino Y
Biochem Biophys Res Commun. 2005
PubMed ID: 16105663
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
Banks AS, Li J, McKeag L, Hribal ML, Kashiwada M, Accili D, Rothman PB
J Clin Invest. 2005
PubMed ID: 16127460
Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.
Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15827066
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis.
Mohanty S, Spinas GA, Maedler K, Zuellig RA, Lehmann R, Donath MY, Trüb T, Niessen M
Exp Cell Res. 2005
PubMed ID: 15572028
Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L
Transgenic Res. 2004
PubMed ID: 15587270
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.
Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF
J Clin Invest. 2004
PubMed ID: 15467829
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance.
Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR
J Clin Invest. 2004
PubMed ID: 15372107
Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3.
Kulkarni RN, Roper MG, Dahlgren G, Shih DQ, Kauri LM, Peters JL, Stoffel M, Kennedy RT
Diabetes. 2004
PubMed ID: 15161756
Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G
Endocrinology. 2004
PubMed ID: 15001544
Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.
Eftychi C, Howson JM, Barratt BJ, Vella A, Payne F, Smyth DJ, Twells RC, Walker NM, Rance HE, Tuomilehto-Wolf E, Tuomilehto J, Undlien DE, Rønningen KS, Guja C, Ionescu-Tîirgovişte C, Savage DA, Todd JA
Diabetes. 2004
PubMed ID: 14988278
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation.
Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF
J Neurosci. 2003
PubMed ID: 12904469
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice.
Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR
Diabetes. 2003
PubMed ID: 12765966
Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells.
Borge PD, Wolf BA
J Biol Chem. 2003
PubMed ID: 12524443
The Gly972-->Arg IRS-1 variant is associated with type 1 diabetes in continental Italy.
Federici M, Petrone A, Porzio O, Bizzarri C, Lauro D, D'Alfonso R, Patera I, Cappa M, Nisticò L, Baroni M, Sesti G, di Mario U, Lauro R, Buzzetti R
Diabetes. 2003
PubMed ID: 12606535
Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice.
Laustsen PG, Michael MD, Crute BE, Cohen SE, Ueki K, Kulkarni RN, Keller SR, Lienhard GE, Kahn CR
Genes Dev. 2002
PubMed ID: 12502742
Blockade of IRS1 in isolated rat pancreatic islets improves glucose-induced insulin secretion.
Araujo EP, Amaral ME, Souza CT, Bordin S, Ferreira F, Saad MJ, Boschero AC, Magalhães EC, Velloso LA
FEBS Lett. 2002
PubMed ID: 12435589
Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes.
Shirakami A, Toyonaga T, Tsuruzoe K, Shirotani T, Matsumoto K, Yoshizato K, Kawashima J, Hirashima Y, Miyamura N, Kahn CR, Araki E
J Endocrinol. 2002
PubMed ID: 12176670
Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ
Endocrinology. 2002
PubMed ID: 11897712
Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2(-/-) mouse liver.
Tobe K, Suzuki R, Aoyama M, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Matsui J, Akanuma Y, Kimura S, Tanaka J, Abe M, Ohsumi J, Nagai R, Kadowaki T
J Biol Chem. 2001
PubMed ID: 11546755
The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans.
Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, Teigeler A, Koch M, Machicao F, Häring H
Diabetes. 2001
PubMed ID: 11289056
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Kubota N, Tobe K, Terauchi Y, Eto K, Yamauchi T, Suzuki R, Tsubamoto Y, Komeda K, Nakano R, Miki H, Satoh S, Sekihara H, Sciacchitano S, Lesniak M, Aizawa S, Nagai R, Kimura S, Akanuma Y, Taylor SI, Kadowaki T
Diabetes. 2000
PubMed ID: 11078455
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.
Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D
J Clin Invest. 2000
PubMed ID: 10642598
Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Terauchi Y, Kubota N, Tamemoto H, Sakura H, Nagai R, Akanuma Y, Kimura S, Kadowaki T
Diabetes. 2000
PubMed ID: 10615953
Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines.
Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR
J Clin Invest. 1999
PubMed ID: 10606633
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF
Nat Genet. 1999
PubMed ID: 10471495
Disruption of IRS-2 causes type 2 diabetes in mice.
Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF
Nature. 1998
PubMed ID: 9495343
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T
J Clin Invest. 1997
PubMed ID: 9062343
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles.
Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR
Cell. 1997
PubMed ID: 9038347
Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.
Clausen JO, Hansen T, Bjørbaek C, Echwald SM, Urhammer SA, Rasmussen S, Andersen CB, Hansen L, Almind K, Winther K
Lancet. 1995
PubMed ID: 7623569
Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus.
Almind K, Bjørbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O
Lancet. 1993
PubMed ID: 8104271

Publications: 606

Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK.
Hitomi H, Mehta PK, Taniyama Y, Lassègue B, Seidel-Rogol B, San Martin A, Griendling KK
Am J Physiol Cell Physiol. 2011
PubMed ID: 21900690
The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
Shi J, Luo L, Eash J, Ibebunjo C, Glass DJ
Dev Cell. 2011
PubMed ID: 22033112
The associations between G972R polymorphism of the IRS-1 gene, insulin resistance, salt sensitivity and non-dipper hypertension.
Dziwura J, Bińczak-Kuleta A, Miazgowski T, Ziemak J, Widecka K
Hypertens Res. 2011
PubMed ID: 21677657
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.
Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, Song C, Arnold AM, Aulchenko YS, Oostra BA, Campbell H, Cupples LA, Davis KE, Döring A, Eiriksdottir G, Estrada K, Fernández-Real JM, Garcia M, Gieger C, Glazer NL, Guiducci C, Hofman A, Humphries SE, Isomaa B, Jacobs LC, Jula A, Karasik D, Karlsson MK, Khaw KT, Kim LJ, Kivimäki M, Klopp N, Kühnel B, Kuusisto J, Liu Y, Ljunggren O, Lorentzon M, Luben RN, McKnight B, Mellström D, Mitchell BD, Mooser V, Moreno JM, Männistö S, O'Connell JR, Pascoe L, Peltonen L, Peral B, Perola M, Psaty BM, Salomaa V, Savage DB, Semple RK, Skaric-Juric T, Sigurdsson G, Song KS, Spector TD, Syvänen AC, Talmud PJ, Thorleifsson G, Thorsteinsdottir U, Uitterlinden AG, van Duijn CM, Vidal-Puig A, Wild SH, Wright AF, Clegg DJ, Schadt E, Wilson JF, Rudan I, Ripatti S, Borecki IB, Shuldiner AR, Ingelsson E, Jansson JO, Kaplan RC, Gudnason V, Harris TB, Groop L, Kiel DP, Rivadeneira F, Walker M, Barroso I, Vollenweider P, Waeber G, Chambers JC, Kooner JS, Soranzo N, Hirschhorn JN, Stefansson K, Wichmann HE, Ohlsson C, O'Rahilly S, Wareham NJ, Speliotes EK, Fox CS, Laakso M, Loos RJ
Nat Genet. 2011
PubMed ID: 21706003
Decreased IGF type 1 receptor signaling in mammary epithelium during pregnancy leads to reduced proliferation, alveolar differentiation, and expression of insulin receptor substrate (IRS)-1 and IRS-2.
Sun Z, Shushanov S, LeRoith D, Wood TL
Endocrinology. 2011
PubMed ID: 21628386
Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells.
Machado-Neto JA, Favaro P, Lazarini M, Costa FF, Olalla Saad ST, Traina F
Biochim Biophys Acta. 2011
PubMed ID: 21569802
Blockade of insulin receptor substrate-1 inhibits corneal lymphangiogenesis.
Hos D, Regenfuss B, Bock F, Onderka J, Cursiefen C
Invest Ophthalmol Vis Sci. 2011
PubMed ID: 21666240
Association study of IRS1 gene polymorphisms with type 2 diabetes in south Indians.
Bodhini D, Radha V, Mohan V
Diabetes Technol Ther. 2011
PubMed ID: 21612394
Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.
Clément S, Peyrou M, Sanchez-Pareja A, Bourgoin L, Ramadori P, Suter D, Vinciguerra M, Guilloux K, Pascarella S, Rubbia-Brandt L, Negro F, Foti M
Hepatology. 2011
PubMed ID: 21465511
Impact of insulin receptor substrate-1 genotypes on platelet reactivity and cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease.
Angiolillo DJ, Bernardo E, Zanoni M, Vivas D, Capranzano P, Malerba G, Capodanno D, Prandini P, Pasquali A, Trabetti E, Sabaté M, Jimenez-Quevedo P, Ferreiro JL, Ueno M, Bass TA, Pignatti PF, Fernandez-Ortiz A, Macaya C
J Am Coll Cardiol. 2011
PubMed ID: 21700086
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T
J Biol Chem. 2011
PubMed ID: 21454638
PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates.
Zhao Y, Biswas SK, McNulty PH, Kozak M, Jun JY, Segar L
Am J Physiol Cell Physiol. 2011
PubMed ID: 21325637
Sex steroids influence glucose oxidation through modulation of insulin receptor expression and IRS-1 serine phosphorylation in target tissues of adult male rat.
Muthusamy T, Murugesan P, Srinivasan C, Balasubramanian K
Mol Cell Biochem. 2011
PubMed ID: 21301931
Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model.
Matsunami T, Sato Y, Ariga S, Sato T, Shimomura T, Kashimura H, Hasegawa Y, Yukawa M
Metabolism. 2011
PubMed ID: 20846698
[LRP16 gene causes insulin resistance in C2-C12 cells by inhibiting the IRS-1 signaling and the transcriptional activity of peroxisome proliferator actived receptor γ].
Zang L, Mu YM, Lü ZH, Xue B, Ma XL, Yang GQ, Ba JM, Dou JT, Lu JM
Zhonghua Yi Xue Za Zhi. 2011
PubMed ID: 21756814
Resistin promotes cardiac hypertrophy via the AMP-activated protein kinase/mammalian target of rapamycin (AMPK/mTOR) and c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathways.
Kang S, Chemaly ER, Hajjar RJ, Lebeche D
J Biol Chem. 2011
PubMed ID: 21478152
The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.
Sharma R, Prudente S, Andreozzi F, Powers C, Mannino G, Bacci S, Gervino EV, Hauser TH, Succurro E, Mercuri L, Goheen EH, Shah H, Trischitta V, Sesti G, Doria A
Atherosclerosis. 2011
PubMed ID: 21353221
Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum.
Barbour LA, McCurdy CE, Hernandez TL, Friedman JE
J Clin Endocrinol Metab. 2011
PubMed ID: 21289241
Rheb is essential for murine development.
Goorden SM, Hoogeveen-Westerveld M, Cheng C, van Woerden GM, Mozaffari M, Post L, Duckers HJ, Nellist M, Elgersma Y
Mol Cell Biol. 2011
PubMed ID: 21321084
Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity.
Mima A, Ohshiro Y, Kitada M, Matsumoto M, Geraldes P, Li C, Li Q, White GS, Cahill C, Rask-Madsen C, King GL
Kidney Int. 2011
PubMed ID: 21228767
Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.
Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
Cell Metab. 2011
PubMed ID: 21356519
Insulin receptor H1085H C>T and insulin receptor substrate 1 G972R polymorphisms and prostate cancer risk: a pilot study.
Saracevic A, Nikolac N, Reljic A, Simundic AM
Genet Test Mol Biomarkers. 2011
PubMed ID: 21204696
Over-expression of NYGGF4 (PID1) inhibits glucose transport in skeletal myotubes by blocking the IRS1/PI3K/AKT insulin pathway.
Wu WL, Gan WH, Tong ML, Li XL, Dai JZ, Zhang CM, Guo XR
Mol Genet Metab. 2011
PubMed ID: 21185755
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways.
Long YC, Cheng Z, Copps KD, White MF
Mol Cell Biol. 2011
PubMed ID: 21135130
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.
Wei D, Tao R, Zhang Y, White MF, Dong XC
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21081708
Rheb1 is required for mTORC1 and myelination in postnatal brain development.
Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B
Dev Cell. 2011
PubMed ID: 21238928
Upregulation of IRS-1 expression in Goto-Kakizaki rats following Roux-en-Y gastric bypass surgery: resolution of type 2 diabetes?
Li SQ, Zhou Y, Wang Y, Liu Y, Geng DH, Liu JG
Tohoku J Exp Med. 2011
PubMed ID: 22001674
Constitutive expression of insulin receptor substrate (IRS)-1 inhibits myogenic differentiation through nuclear exclusion of Foxo1 in L6 myoblasts.
Hakuno F, Yamauchi Y, Kaneko G, Yoneyama Y, Nakae J, Chida K, Kadowaki T, Yamanouchi K, Nishihara M, Takahashi S
PLoS One. 2011
PubMed ID: 21991327
The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes.
Ryu HS, Park SY, Ma D, Zhang J, Lee W
PLoS One. 2011
PubMed ID: 21464990
Replication of extended lifespan phenotype in mice with deletion of insulin receptor substrate 1.
Selman C, Partridge L, Withers DJ
PLoS One. 2011
PubMed ID: 21283571
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Genetic variants of the insulin receptor substrate-1 are influencing the therapeutic efficacy of oral antidiabetics.
Seeringer A, Parmar S, Fischer A, Altissimo B, Zondler L, Lebedeva E, Pitterle K, Roots I, Kirchheiner J
Diabetes Obes Metab. 2010
PubMed ID: 20977583
Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.
Peloso GM, Demissie S, Collins D, Mirel DB, Gabriel SB, Cupples LA, Robins SJ, Schaefer EJ, Brousseau ME
J Lipid Res. 2010
PubMed ID: 20855565
Mitochondrial and nuclear gene mutations in the type 2 diabetes patients of Coimbatore population.
Vijaya Padma V, Anitha S, Santhini E, Pradeepa D, Tresa D, Ganesan P, Ishwarya P, Balakrishnan R
Mol Cell Biochem. 2010
PubMed ID: 20730618
A novel domain mediates insulin-induced proteasomal degradation of insulin receptor substrate 1 (IRS-1).
Boura-Halfon S, Shuster-Meiseles T, Beck A, Petrovich K, Gurevitch D, Ronen D, Zick Y
Mol Endocrinol. 2010
PubMed ID: 20843941
An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol.
Walker MP, Diaugustine RP, Zeringue E, Bunger MK, Schmitt M, Archer TK, Richards RG
J Endocrinol. 2010
PubMed ID: 20798132
The double-stranded RNA-dependent protein kinase differentially regulates insulin receptor substrates 1 and 2 in HepG2 cells.
Yang X, Nath A, Opperman MJ, Chan C
Mol Biol Cell. 2010
PubMed ID: 20685959
Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
Diabetes. 2010
PubMed ID: 20682687
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20673868
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS
Hum Mol Genet. 2010
PubMed ID: 20634197
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.
Fontaine-Bisson B, Renström F, Rolandsson O, MAGIC, Payne F, Hallmans G, Barroso I, Franks PW
Diabetologia. 2010
PubMed ID: 20571754
A candidate gene study of obstructive sleep apnea in European Americans and African Americans.
Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, Gray-McGuire C, Adams MD, Redline S
Am J Respir Crit Care Med. 2010
PubMed ID: 20538960
Nuclear IRS-1 predicts tamoxifen response in patients with early breast cancer.
Migliaccio I, Wu MF, Gutierrez C, Malorni L, Mohsin SK, Allred DC, Hilsenbeck SG, Osborne CK, Weiss H, Lee AV
Breast Cancer Res Treat. 2010
PubMed ID: 19924529
Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.
Westrick RJ, Mohlke KL, Korepta LM, Yang AY, Zhu G, Manning SL, Winn ME, Dougherty KM, Ginsburg D
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20837540
The insulin sensitivity response is determined by the interaction between the G972R polymorphism of the insulin receptor substrate 1 gene and dietary fat.
Marín C, Pérez-Martínez P, Delgado-Lista J, Gómez P, Rodríguez F, Yubero-Serrano EM, García-Ríos A, Camargo A, Pérez-Jiménez F, López-Miranda J
Mol Nutr Food Res. 2010
PubMed ID: 20824664
Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1.
DeAngelis T, Morrione A, Baserga R
J Cell Physiol. 2010
PubMed ID: 20578241
Insulin receptor substrate 1 regulates the cellular differentiation and the matrix metallopeptidase expression of preosteoblastic cells.
Bu YH, He YL, Zhou HD, Liu W, Peng D, Tang AG, Tang LL, Xie H, Huang QX, Luo XH, Liao EY
J Endocrinol. 2010
PubMed ID: 20525764
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Faerch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Hansen T, Pedersen O
Diabetologia. 2010
PubMed ID: 20490451
Additive effect of multiple genetic variants on the risk of coronary artery disease.
Lluís-Ganella C, Lucas G, Subirana I, Sentí M, Jimenez-Conde J, Marrugat J, Tomás M, Elosua R
Rev Esp Cardiol. 2010
PubMed ID: 20738937
Nitric oxide inhibits the proliferation and invasion of pancreatic cancer cells through degradation of insulin receptor substrate-1 protein.
Sugita H, Kaneki M, Furuhashi S, Hirota M, Takamori H, Baba H
Mol Cancer Res. 2010
PubMed ID: 20663861
Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.
Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL, Li D
Gastroenterology. 2010
PubMed ID: 20416304
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
Pharmacogenomics. 2010
PubMed ID: 20602615
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
Hawken SJ, Greenwood CM, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J
Hum Genet. 2010
PubMed ID: 20437058
AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation.
Ning J, Clemmons DR
Mol Endocrinol. 2010
PubMed ID: 20363874
No association of the G972S polymorphism of the insulin receptor substrate-1 gene with polycystic ovary syndrome in lean PCOS women with biochemical hyperandrogenemia.
Marioli DJ, Koika V, Adonakis GL, Saltamavros AD, Karela A, Armeni AK, Tsapanos VS, Decavalas GO, Georgopoulos NA
Arch Gynecol Obstet. 2010
PubMed ID: 20012307
Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.
Radhakrishnan Y, Busby WH, Shen X, Maile LA, Clemmons DR
J Biol Chem. 2010
PubMed ID: 20207740
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20452482
The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome.
Dravecká I, Lazúrová I, Habalová V
Gynecol Endocrinol. 2010
PubMed ID: 20170352
Effects of testosterone and metformin on glucose metabolism in endometrium.
Zhang L, Liao Q
Fertil Steril. 2010
PubMed ID: 19328476
Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism.
Ruchat SM, Vohl MC, Weisnagel SJ, Rankinen T, Bouchard C, Pérusse L
Ann Med. 2010
PubMed ID: 20384434
Chronic inhibition of the mTORC1/S6K1 pathway increases insulin-induced PI3K activity but inhibits Akt2 and glucose transport stimulation in 3T3-L1 adipocytes.
Veilleux A, Houde VP, Bellmann K, Marette A
Mol Endocrinol. 2010
PubMed ID: 20203102
Very High Frequency of the Polymorphism for the Insulin Receptor Substrate 1 (IRS-1) at Codon 972 (Glycine972Arginine) in Southern Italian Women with Polycystic Ovary Syndrome.
Pappalardo MA, Russo GT, Pedone A, Pizzo A, Borrielli I, Stabile G, Artenisio AC, Amato A, Calvani M, Cucinotta D, Trimarchi F, Benvenga S
Horm Metab Res. 2010
PubMed ID: 20229450
Study of association of IRS-1 and IRS-2 genes polymorphisms with clinical and metabolic features in women with polycystic ovary syndrome. Is there an impact?
Christopoulos P, Mastorakos G, Gazouli M, Deligeoroglou E, Katsikis I, Diamanti-Kandarakis E, Panidis D, Creatsas G
Gynecol Endocrinol. 2010
PubMed ID: 20210696
Loss of inhibitory insulin receptor substrate-1 phosphorylation is an early event in mammalian target of rapamycin-dependent endometrial hyperplasia and carcinoma.
McCampbell AS, Harris HA, Crabtree JS, Winneker RC, Walker CL, Broaddus RR
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20179297
Mechanisms underlying catabolic and anabolic functions of parathyroid hormone on bone by combination of culture systems of mouse cells.
Shinoda Y, Kawaguchi H, Higashikawa A, Hirata M, Miura T, Saito T, Nakamura K, Chung UI, Ogata N
J Cell Biochem. 2010
PubMed ID: 20058231
A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis.
DeMambro VE, Kawai M, Clemens TL, Fulzele K, Maynard JA, Marín de Evsikova C, Johnson KR, Canalis E, Beamer WG, Rosen CJ, Donahue LR
J Endocrinol. 2010
PubMed ID: 20032200
Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.
González-Rodríguez A, Mas Gutierrez JA, Sanz-González S, Ros M, Burks DJ, Valverde AM
Diabetes. 2010
PubMed ID: 20028942
Overexpression of Foxf2 in adipose tissue is associated with lower levels of IRS1 and decreased glucose uptake in vivo.
Westergren R, Nilsson D, Heglind M, Arani Z, Grände M, Cederberg A, Ahrén B, Enerbäck S
Am J Physiol Endocrinol Metab. 2010
PubMed ID: 20009030
Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.
Meng X, Kondo M, Morino K, Fuke T, Obata T, Yoshizaki T, Ugi S, Nishio Y, Maeda S, Araki E, Kashiwagi A, Maegawa H
Biochem Biophys Res Commun. 2010
PubMed ID: 20097161
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes.
Whelan SA, Dias WB, Thiruneelakantapillai L, Lane MD, Hart GW
J Biol Chem. 2010
PubMed ID: 20018868
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS
Cell. 2010
PubMed ID: 20144759
Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease.
Dongiovanni P, Valenti L, Rametta R, Daly AK, Nobili V, Mozzi E, Leathart JB, Pietrobattista A, Burt AD, Maggioni M, Fracanzani AL, Lattuada E, Zappa MA, Roviaro G, Marchesini G, Day CP, Fargion S
Gut. 2010
PubMed ID: 20176643
Polymorphisms of the insulin receptor and the insulin receptor substrates genes in polycystic ovary syndrome: a Mendelian randomization meta-analysis.
Ioannidis A, Ikonomi E, Dimou NL, Douma L, Bagos PG
Mol Genet Metab. 2010
PubMed ID: 19926323
IRS1 regulation by Wnt/beta-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype.
Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, Kadikoy H, Sikorski D, Wu R, Cho KR, Fearon ER
J Biol Chem. 2010
PubMed ID: 19843521
Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle.
Pilon G, Charbonneau A, White PJ, Dallaire P, Perreault M, Kapur S, Marette A
PLoS One. 2010
PubMed ID: 21206533
[A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]
Lisitskaia KV, Krakhmaleva IN, Shishkin SS
Mol Gen Mikrobiol Virusol. 2010
PubMed ID: 20540360
Relationship of five type 2 diabetes candidate gene polymorphisms to the age at diagnosis of diabetes in the Slovakian population.
Kozarova M, Javorsky M, Stancakova A, Dobrikova M, Habalova V, Klimcakova L, Zidzik J, Haluskova J, Salagovic J, Tkac I
Bratisl Lek Listy. 2010
PubMed ID: 20437825
Identification of type 2 diabetes-associated combination of SNPs using support vector machine.
Ban HJ, Heo JY, Oh KS, Park KJ
BMC Genet. 2010
PubMed ID: 20416077
Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3.
Kim K, Kim KH, Cheong J
PLoS One. 2010
PubMed ID: 20351777
Irs1 serine 307 promotes insulin sensitivity in mice.
Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF
Cell Metab. 2010
PubMed ID: 20074531
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation.
Fernandez-L A, Northcott PA, Dalton J, Fraga C, Ellison D, Angers S, Taylor MD, Kenney AM
Genes Dev. 2009
PubMed ID: 19952108
Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats.
Zheng Y, Zhang W, Pendleton E, Leng S, Wu J, Chen R, Sun XJ
J Endocrinol. 2009
PubMed ID: 19801385
O-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.
Klein AL, Berkaw MN, Buse MG, Ball LE
Mol Cell Proteomics. 2009
PubMed ID: 19671924
Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK.
Archuleta TL, Lemieux AM, Saengsirisuwan V, Teachey MK, Lindborg KA, Kim JS, Henriksen EJ
Free Radic Biol Med. 2009
PubMed ID: 19703555
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Subcellular localization of IRS-1 in IGF-I-mediated chondrogenic proliferation, differentiation and hypertrophy of bone marrow mesenchymal stem cells.
Longobardi L, Granero-Moltó F, O'Rear L, Myers TJ, Li T, Kregor PJ, Spagnoli A
Growth Factors. 2009
PubMed ID: 19639489
Degradation of IRS1 leads to impaired glucose uptake in adipose tissue of the type 2 diabetes mouse model TALLYHO/Jng.
Wang Y, Nishina PM, Naggert JK
J Endocrinol. 2009
PubMed ID: 19587264
Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice.
Bai X, Chen X, Liu Y, Tian L, Zhou Q, Liu S, Fang J, Chen J
J Ethnopharmacol. 2009
PubMed ID: 19607904
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.
Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF
Mol Cell Biol. 2009
PubMed ID: 19596788
High-fat diet induces Ikkbeta and reduces insulin sensitivity in rats with low running capacity.
Bikman BT, Woodlief TL, Noland RC, Britton SL, Koch LG, Lust RM, Dohm GL, Cortright RN
Int J Sports Med. 2009
PubMed ID: 19569009
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
Morini E, Prudente S, Succurro E, Chandalia M, Zhang YY, Mammarella S, Pellegrini F, Powers C, Proto V, Dallapiccola B, Cama A, Sesti G, Abate N, Doria A, Trischitta V
Diabetologia. 2009
PubMed ID: 19557384
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading.
Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, Okumura Y, Nonaka I, Yasutomo K, Baldwin KM, Kominami E, Higashibata A, Nagano K, Tanaka K, Yasui N, Mills EM, Takeda S, Nikawa T
Mol Cell Biol. 2009
PubMed ID: 19546233
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins.
Morris DL, Cho KW, Zhou Y, Rui L
Diabetes. 2009
PubMed ID: 19542202
Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR.
Tzatsos A
J Biol Chem. 2009
PubMed ID: 19561084
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y
Int J Mol Med. 2009
PubMed ID: 19578796
Bidirectional regulation of insulin receptor autophosphorylation and kinase activity by peroxynitrite.
Zhou J, He X, Huang K
Arch Biochem Biophys. 2009
PubMed ID: 19560437
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway.
La Rocca G, Badin M, Shi B, Xu SQ, Deangelis T, Sepp-Lorenzinoi L, Baserga R
J Cell Physiol. 2009
PubMed ID: 19391107
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells.
White SR, Martin LD, Abe MK, Marroquin BA, Stern R, Fu X
Am J Physiol Lung Cell Mol Physiol. 2009
PubMed ID: 19447894
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles.
Pollizzi K, Malinowska-Kolodziej I, Doughty C, Betz C, Ma J, Goto J, Kwiatkowski DJ
Hum Mol Genet. 2009
PubMed ID: 19357198
Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA
Biol Reprod. 2009
PubMed ID: 19228596
Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver.
Longato L, de la Monte S, Kuzushita N, Horimoto M, Rogers AB, Slagle BL, Wands JR
Hepatology. 2009
PubMed ID: 19475691
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle.
Yaspelkis BB, Kvasha IA, Figueroa TY
Am J Physiol Regul Integr Comp Physiol. 2009
PubMed ID: 19386987
Increased expression of both insulin receptor substrates 1 and 2 confers increased sensitivity to IGF-1 stimulated cell migration.
de Blaquière GE, May FE, Westley BR
Endocr Relat Cancer. 2009
PubMed ID: 19261680
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN).
Yamamoto R, Nagasawa Y, Shoji T, Inoue K, Uehata T, Kaneko T, Okada T, Yamauchi A, Tsubakihara Y, Imai E, Isaka Y, Rakugi H
Nephrol Dial Transplant. 2009
PubMed ID: 19420105
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Effects of aging on the expressions of insulin receptor substrate-1, phosphate protein kinase B in rat liver and muscle]
Wang S, Meng ZM, Li XJ
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19626997
Glucose transporter 4 and insulin receptor substrate-1 messenger RNA expression in omental and subcutaneous adipose tissue in women.
Veilleux A, Blouin K, Rhéaume C, Daris M, Marette A, Tchernof A
Metabolism. 2009
PubMed ID: 19375584
Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.
Kim B, Feldman EL
Apoptosis. 2009
PubMed ID: 19259821
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.
Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, Del Valle L, Khalili K, Reiss K
J Cell Physiol. 2009
PubMed ID: 19117011
Insulin receptor substrate 1 modulates the transcriptional activity and the stability of androgen receptor in breast cancer cells.
Lanzino M, Garofalo C, Morelli C, Le Pera M, Casaburi I, McPhaul MJ, Surmacz E, Andò S, Sisci D
Breast Cancer Res Treat. 2009
PubMed ID: 18521741
Interruption of growth hormone signaling via SHC and ERK in 3T3-F442A preadipocytes upon knockdown of insulin receptor substrate-1.
Wang X, Yang N, Deng L, Li X, Jiang J, Gan Y, Frank SJ
Mol Endocrinol. 2009
PubMed ID: 19164446
The insulin receptor substrate-1: a biomarker for cancer?
Baserga R
Exp Cell Res. 2009
PubMed ID: 18851963
The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.
Hanke S, Mann M
Mol Cell Proteomics. 2009
PubMed ID: 19001411
[Research of the relationship between insulin signal transduction and glucose transportation in rats after trauma]
Jiang Y, Wu GH
Zhonghua Wai Ke Za Zhi. 2009
PubMed ID: 19563078
Adiponectin improves cardiomyocyte contractile function in db/db diabetic obese mice.
Dong F, Ren J
Obesity (Silver Spring). 2009
PubMed ID: 19057532
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
Clin Chim Acta. 2009
PubMed ID: 18996102
Chronic-intermittent cold stress in rats induces selective ovarian insulin resistance.
Dorfman M, Ramirez VD, Stener-Victorin E, Lara HE
Biol Reprod. 2009
PubMed ID: 18923160
Colon tumor mutations and epigenetic changes associated with genetic polymorphism: insight into disease pathways.
Slattery ML, Wolff RK, Curtin K, Fitzpatrick F, Herrick J, Potter JD, Caan BJ, Samowitz WS
Mutat Res. 2009
PubMed ID: 18992263
Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers.
Neuhausen SL, Brummel S, Ding YC, Singer CF, Pfeiler G, Lynch HT, Nathanson KL, Rebbeck TR, Garber JE, Couch F, Weitzel J, Narod SA, Ganz PA, Daly MB, Godwin AK, Isaacs C, Olopade OI, Tomlinson G, Rubinstein WS, Tung N, Blum JL, Gillen DL
Breast Cancer Res. 2009
PubMed ID: 19843326
SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells.
Persico M, Russo R, Persico E, Svelto M, Spano D, Andolfo I, La Mura V, Capasso M, Tiribelli C, Torella R, Iolascon A
Clin Chem Lab Med. 2009
PubMed ID: 19803812
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
Low aerobic capacity and high-fat diet contribute to oxidative stress and IRS-1 degradation in the kidney.
Morris EM, Whaley-Connell AT, Thyfault JP, Britton SL, Koch LG, Wei Y, Ibdah JA, Sowers JR
Am J Nephrol. 2009
PubMed ID: 19229113
Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance.
Allemand MC, Irving BA, Asmann YW, Klaus KA, Tatpati L, Coddington CC, Nair KS
PLoS One. 2009
PubMed ID: 19169352
Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
Birmann BM, Tamimi RM, Giovannucci E, Rosner B, Hunter DJ, Kraft P, Mitsiades C, Anderson KC, Colditz GA
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124510
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt.
Zhang CM, Chen XH, Wang B, Liu F, Chi X, Tong ML, Ni YH, Chen RH, Guo XR
Acta Pharmacol Sin. 2009
PubMed ID: 19079291
The IGF system in in-vitro human decidualization.
Ganeff C, Chatel G, Munaut C, Frankenne F, Foidart JM, Winkler R
Mol Hum Reprod. 2009
PubMed ID: 19038974
In skeletal muscle advanced glycation end products (AGEs) inhibit insulin action and induce the formation of multimolecular complexes including the receptor for AGEs.
Cassese A, Esposito I, Fiory F, Barbagallo AP, Paturzo F, Mirra P, Ulianich L, Giacco F, Iadicicco C, Lombardi A, Oriente F, Van Obberghen E, Beguinot F, Formisano P, Miele C
J Biol Chem. 2008
PubMed ID: 18955497
S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2.
Zhang J, Gao Z, Yin J, Quon MJ, Ye J
J Biol Chem. 2008
PubMed ID: 18952604
[Study on the mechanism of insulin resistance in rats born with intrauterine growth retardation]
Liao Y, Li HQ, Deng B, Qu P
Beijing Da Xue Xue Bao. 2008
PubMed ID: 19088829
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19066218
Remote changes in the dynamics of the phosphotyrosine-binding domain of insulin receptor substrate-1 induced by phosphopeptide binding.
Jarymowycz VA, Stone MJ
Biochemistry. 2008
PubMed ID: 19053277
Selective regulation of heme oxygenase-1 expression and function by insulin through IRS1/phosphoinositide 3-kinase/Akt-2 pathway.
Geraldes P, Yagi K, Ohshiro Y, He Z, Maeno Y, Yamamoto-Hiraoka J, Rask-Madsen C, Chung SW, Perrella MA, King GL
J Biol Chem. 2008
PubMed ID: 18854316
The cell growth suppressor, mir-126, targets IRS-1.
Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D
Biochem Biophys Res Commun. 2008
PubMed ID: 18834857
Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells.
Weigert C, Kron M, Kalbacher H, Pohl AK, Runge H, Häring HU, Schleicher E, Lehmann R
Mol Endocrinol. 2008
PubMed ID: 18927238
Inhibition of gluconeogenesis in primary hepatocytes by stromal cell-derived factor-1 (SDF-1) through a c-Src/Akt-dependent signaling pathway.
Liu HY, Wen GB, Han J, Hong T, Zhuo D, Liu Z, Cao W
J Biol Chem. 2008
PubMed ID: 18786922
[Polymorphism of glucose intolerance and insulin resistance susceptibility genes in oncological patients]
Ulybina IuM, Imianitov EN, Vasil'ev DA, Bershteĭn LM
Mol Biol (Mosk). 2008
PubMed ID: 19140314
Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency.
Hu J, Klein JD, Du J, Wang XH
Endocrinology. 2008
PubMed ID: 18653708
Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.
Parathath SR, Mainwaring LA, Fernandez-L A, Campbell DO, Kenney AM
Development. 2008
PubMed ID: 18755774
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle.
Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI
Diabetes. 2008
PubMed ID: 18633112
Regulation of insulin receptor substrate-1 expression levels by caveolin-1.
Chen J, Capozza F, Wu A, Deangelis T, Sun H, Lisanti M, Baserga R
J Cell Physiol. 2008
PubMed ID: 18506777
Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model.
O'Brien K, Sekimoto H, Boney C, Malee M
J Matern Fetal Neonatal Med. 2008
PubMed ID: 18828053
Analysis of the Association of Preeclampsia with Polymorphisms of the INS, INSR and IRS1 Genes in Mexican Women.
Machorro-Lazo MV, Sanchez-Corona J, Martínez-Abundis E, González-Ortiz M, Galaviz-Hernandez C, Perea FJ, Garcia-Zapien AG, Cruz-Quevedo EG, Salgado-Goytia L, Moran-Moguel MC, Flores-Martínez SE
Gynecol Obstet Invest. 2008
PubMed ID: 18716398
Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction.
Kawakami A, Osaka M, Tani M, Azuma H, Sacks FM, Shimokado K, Yoshida M
Circulation. 2008
PubMed ID: 18663085
Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity.
Jensen J, Grønning-Wang LM, Jebens E, Whitehead JP, Zorec R, Shepherd PR
Pflugers Arch. 2008
PubMed ID: 18299886
Antineoplastic effect of rapamycin is potentiated by inhibition of IRS-1 signaling in prostate cancer cells xenografts.
Oliveira JC, Souza KK, Dias MM, Faria MC, Ropelle ER, Flores MB, Ueno M, Velloso LA, Saad ST, Saad MJ, Carvalheira JB
J Cancer Res Clin Oncol. 2008
PubMed ID: 18264722
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk.
Fall K, Stark JR, Mucci LA, Chan J, Stampfer MJ, Kurth T, Febbo PG, Kantoff P, Ma J
Prostate. 2008
PubMed ID: 18615538
Genetic variation in candidate obesity genes ADRB2, ADRB3, GHRL, HSD11B1, IRS1, IRS2, and SHC1 and risk for breast cancer in the Cancer Prevention Study II.
Feigelson HS, Teras LR, Diver WR, Tang W, Patel AV, Stevens VL, Calle EE, Thun MJ, Bouzyk M
Breast Cancer Res. 2008
PubMed ID: 18611262
The role of insulin receptor substrate-1 in the oncogenicity of simian virus 40 T antigen.
Wu A, Chen J, Baserga R
Cell Cycle. 2008
PubMed ID: 18642444
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation.
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF
Cell Metab. 2008
PubMed ID: 18590693
Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding.
Kubota N, Kubota T, Itoh S, Kumagai H, Kozono H, Takamoto I, Mineyama T, Ogata H, Tokuyama K, Ohsugi M, Sasako T, Moroi M, Sugi K, Kakuta S, Iwakura Y, Noda T, Ohnishi S, Nagai R, Tobe K, Terauchi Y, Ueki K, Kadowaki T
Cell Metab. 2008
PubMed ID: 18590692
The double life of Irs.
Haeusler RA, Accili D
Cell Metab. 2008
PubMed ID: 18590687
[Expression and activation of insulin receptor substrate-1 in endometrial carcinoma].
Hua SF, Xue FX, Zhang LZ, Wang YM, Zhao J
Zhonghua Fu Chan Ke Za Zhi. 2008
PubMed ID: 19035139
[Bushen Huoxue Huayu Recipe up-regulates expression of insulin receptor substrate-1 and phosphorylation of tyrosine in adipose tissue in androgen sterilized rats]
Li XL, Wang ZZ, Yu CQ
Zhong Xi Yi Jie He Xue Bao. 2008
PubMed ID: 18559242
The role of insulin receptor substrate-1 in transformation by v-src.
Sun H, Baserga R
J Cell Physiol. 2008
PubMed ID: 18064649
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
Xu X, Sarikas A, Dias-Santagata DC, Dolios G, Lafontant PJ, Tsai SC, Zhu W, Nakajima H, Nakajima HO, Field LJ, Wang R, Pan ZQ
Mol Cell. 2008
PubMed ID: 18498745
The polymorphism in insulin receptor substrate-1 gene and birth weight in neonates at term.
Simońska-Cichocka E, Gumprecht J, Zychma M, Witkowska A, Misiołek H, Slawska H, Oslislo A, Grzeszczak W
Endokrynol Pol. 2008
PubMed ID: 18615395
AHSG tag single nucleotide polymorphisms associate with type 2 diabetes and dyslipidemia: studies of metabolic traits in 7,683 white Danish subjects.
Andersen G, Burgdorf KS, Sparsø T, Borch-Johnsen K, Jørgensen T, Hansen T, Pedersen O
Diabetes. 2008
PubMed ID: 18316360
Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt.
Yu Y, Alwine JC
J Virol. 2008
PubMed ID: 18305032
Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
Lee S, Lynn EG, Kim JA, Quon MJ
Endocrinology. 2008
PubMed ID: 18202124
Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells.
Waraich RS, Weigert C, Kalbacher H, Hennige AM, Lutz SZ, Häring HU, Schleicher ED, Voelter W, Lehmann R
J Biol Chem. 2008
PubMed ID: 18285345
Genetic polymorphisms involved in insulin-like growth factor (IGF) pathway in relation to mammographic breast density and IGF levels.
Diorio C, Brisson J, Bérubé S, Pollak M
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18398029
Age-related insulin resistance in hypothalamus and peripheral tissues of orexin knockout mice.
Tsuneki H, Murata S, Anzawa Y, Soeda Y, Tokai E, Wada T, Kimura I, Yanagisawa M, Sakurai T, Sasaoka T
Diabetologia. 2008
PubMed ID: 18256806
No association between common Gly972Arg variant of the insulin receptor substrate-1 and polycystic ovary syndrome in Southern Chilean women.
Valdés P, Cerda A, Barrenechea C, Kehr M, Soto C, Salazar LA
Clin Chim Acta. 2008
PubMed ID: 18222120
Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions.
Slattery ML, Wolff RK, Herrick J, Caan BJ, Potter JD
Int J Cancer. 2008
PubMed ID: 18059035
Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells.
Varma S, Khandelwal RL
J Cell Biochem. 2008
PubMed ID: 17721885
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR
J Proteome Res. 2008
PubMed ID: 18220336
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson IC, Thornton JM, Gems D, Partridge L, Withers DJ
FASEB J. 2008
PubMed ID: 17928362
Secretion of atherogenic risk factor apolipoprotein B-100 is increased by a potential mechanism of JNK/PKC-mediated insulin resistance in liver cells.
Jin UH, Kang YJ, Chang YC, Kim CH
J Cell Biochem. 2008
PubMed ID: 17647275
A chronic increase in physical activity inhibits fed-state mTOR/S6K1 signaling and reduces IRS-1 serine phosphorylation in rat skeletal muscle.
Glynn EL, Lujan HL, Kramer VJ, Drummond MJ, DiCarlo SE, Rasmussen BB
Appl Physiol Nutr Metab. 2008
PubMed ID: 18347658
Insulin resistance affects gene expression in endothelium.
Consoli C, Martelli E, D'Adamo M, Menghini R, Arcelli D, Porzio O, Pandolfi A, Pistolese GR, Consoli A, Lauro R, Ippoliti A, Federici M
Arterioscler Thromb Vasc Biol. 2008
PubMed ID: 18216326
Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats.
Pauli JR, Ropelle ER, Cintra DE, Carvalho-Filho MA, Moraes JC, De Souza CT, Velloso LA, Carvalheira JB, Saad MJ
J Physiol. 2008
PubMed ID: 17974582
Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance.
Beyer TA, Xu W, Teupser D, auf dem Keller U, Bugnon P, Hildt E, Thiery J, Kan YW, Werner S
EMBO J. 2008
PubMed ID: 18059474
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.
Küry S, Buecher B, Robiou-du-Pont S, Scoul C, Colman H, Le Neel T, Le Houérou C, Faroux R, Ollivry J, Lafraise B, Chupin LD, Sébille V, Bézieau S
BMC Cancer. 2008
PubMed ID: 18992148
Genetic variants associated with insulin resistance and metabolic syndrome in young Asian Indians with myocardial infarction.
Ranjith N, Pegoraro RJ, Naidoo DP, Shanmugam R, Rom L
Metab Syndr Relat Disord. 2008
PubMed ID: 18710329
Acute-phase serum amyloid A as a marker of insulin resistance in mice.
Scheja L, Heese B, Zitzer H, Michael MD, Siesky AM, Pospisil H, Beisiegel U, Seedorf K
Exp Diabetes Res. 2008
PubMed ID: 18584041
Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9.
Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK
Endocrinology. 2008
PubMed ID: 17916629
53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.
Hakuno F, Kurihara S, Watson RT, Pessin JE, Takahashi S
J Biol Chem. 2007
PubMed ID: 17965023
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway.
Hers I
Blood. 2007
PubMed ID: 17827393
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance.
Murata Y, Tsuruzoe K, Kawashima J, Furukawa N, Kondo T, Motoshima H, Igata M, Taketa K, Sasaki K, Kishikawa H, Kahn CR, Toyonaga T, Araki E
Biochem Biophys Res Commun. 2007
PubMed ID: 17950694
Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling.
Martin KA, Merenick BL, Ding M, Fetalvero KM, Rzucidlo EM, Kozul CD, Brown DJ, Chiu HY, Shyu M, Drapeau BL, Wagner RJ, Powell RJ
J Biol Chem. 2007
PubMed ID: 17908691
Role of insulin receptor substrate-1 serine 307 phosphorylation and adiponectin in adipose tissue insulin resistance in late pregnancy.
Sevillano J, de Castro J, Bocos C, Herrera E, Ramos MP
Endocrinology. 2007
PubMed ID: 17823255
Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses.
Jensen M, Hansen B, De Meyts P, Schäffer L, Ursø B
J Biol Chem. 2007
PubMed ID: 17925406
Human, but not rat, IRS1 targets to the plasma membrane in both human and rat adipocytes.
Stenkula KG, Thorn H, Franck N, Hallin E, Sauma L, Nystrom FH, Strålfors P
Biochem Biophys Res Commun. 2007
PubMed ID: 17905199
Effects of triglyceride on ER stress and insulin resistance.
Kim DS, Jeong SK, Kim HR, Kim DS, Chae SW, Chae HJ
Biochem Biophys Res Commun. 2007
PubMed ID: 17868644
Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells.
Shi B, Sepp-Lorenzino L, Prisco M, Linsley P, deAngelis T, Baserga R
J Biol Chem. 2007
PubMed ID: 17827156
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth.
Simmons JG, Ling Y, Wilkins H, Fuller CR, D'Ercole AJ, Fagin J, Lund PK
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17823215
Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases.
Levkovitz Y, Ben-Shushan G, Hershkovitz A, Isaac R, Gil-Ad I, Shvartsman D, Ronen D, Weizman A, Zick Y
Mol Cell Neurosci. 2007
PubMed ID: 17728140
Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal.
Rubin R, Arzumanyan A, Soliera AR, Ross B, Peruzzi F, Prisco M
J Cell Physiol. 2007
PubMed ID: 17620314
Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.
Ost A, Danielsson A, Lidén M, Eriksson U, Nystrom FH, Strålfors P
FASEB J. 2007
PubMed ID: 17575262
Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology.
Sadagurski M, Nofech-Mozes S, Weingarten G, White MF, Kadowaki T, Wertheimer E
J Cell Physiol. 2007
PubMed ID: 17508357
Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells.
Hitomi H, Kiyomoto H, Nishiyama A, Hara T, Moriwaki K, Kaifu K, Ihara G, Fujita Y, Ugawa T, Kohno M
Hypertension. 2007
PubMed ID: 17646573
Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling.
Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ
Endocrinology. 2007
PubMed ID: 17640984
Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
Pechlivanis S, Pardini B, Bermejo JL, Wagner K, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P, Försti A
Endocr Relat Cancer. 2007
PubMed ID: 17914103
Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution.
Qian YS, Zhou XO, Zhang Y, Gao PJ, Zhang WZ, Zhu DL
Chin J Integr Med. 2007
PubMed ID: 17898946
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors.
Bantscheff M, Eberhard D, Abraham Y, Bastuck S, Boesche M, Hobson S, Mathieson T, Perrin J, Raida M, Rau C, Reader V, Sweetman G, Bauer A, Bouwmeester T, Hopf C, Kruse U, Neubauer G, Ramsden N, Rick J, Kuster B, Drewes G
Nat Biotechnol. 2007
PubMed ID: 17721511
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM
Dev Biol. 2007
PubMed ID: 17662267
Dual regulation of upstream binding factor 1 levels by IRS-1 and ERKs in IGF-1-receptor signaling.
Sun H, Tu X, Liu M, Baserga R
J Cell Physiol. 2007
PubMed ID: 17443674
Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population.
Baba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, Saito T
Life Sci. 2007
PubMed ID: 17719609
Interaction between serine phosphorylated IRS-1 and beta1-integrin affects the stability of neuronal processes.
Wang JY, Gualco E, Peruzzi F, Sawaya BE, Passiatore G, Marcinkiewicz C, Staniszewska I, Ferrante P, Amini S, Khalili K, Reiss K
J Neurosci Res. 2007
PubMed ID: 17593555
Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt.
Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV
J Endocrinol. 2007
PubMed ID: 17641282
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ
Diabetes. 2007
PubMed ID: 17519423
Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.
Giani JF, Gironacci MM, Muñoz MC, Peña C, Turyn D, Dominici FP
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17496209
Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States.
Slattery ML, Sweeney C, Wolff R, Herrick J, Baumgartner K, Giuliano A, Byers T
Breast Cancer Res Treat. 2007
PubMed ID: 17051426
The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation.
Dromard M, Bompard G, Glondu-Lassis M, Puech C, Chalbos D, Freiss G
Cancer Res. 2007
PubMed ID: 17638892
Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.
Tzatsos A, Tsichlis PN
J Biol Chem. 2007
PubMed ID: 17459875
Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance.
Herschkovitz A, Liu YF, Ilan E, Ronen D, Boura-Halfon S, Zick Y
J Biol Chem. 2007
PubMed ID: 17446166
The estrogen receptor alpha:insulin receptor substrate 1 complex in breast cancer: structure-function relationships.
Sisci D, Morelli C, Cascio S, Lanzino M, Garofalo C, Reiss K, Garcia M, Russo A, Andò S, Surmacz E
Ann Oncol. 2007
PubMed ID: 17591841
Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.
Florez JC, Sjögren M, Agapakis CM, Burtt NP, Almgren P, Lindblad U, Berglund G, Tuomi T, Gaudet D, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L
Diabetologia. 2007
PubMed ID: 17443311
Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes.
Ishizuka K, Usui I, Kanatani Y, Bukhari A, He J, Fujisaka S, Yamazaki Y, Suzuki H, Hiratani K, Ishiki M, Iwata M, Urakaze M, Haruta T, Kobayashi M
Endocrinology. 2007
PubMed ID: 17379643
Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle.
Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ
Diabetes. 2007
PubMed ID: 17360977
The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms.
Pazienza V, Clément S, Pugnale P, Conzelman S, Foti M, Mangia A, Negro F
Hepatology. 2007
PubMed ID: 17465001
Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.
Denley A, Carroll JM, Brierley GV, Cosgrove L, Wallace J, Forbes B, Roberts CT
Mol Cell Biol. 2007
PubMed ID: 17325037
Insulin resistance-related genes and advanced left-sided colorectal adenoma.
Gunter MJ, Hayes RB, Chatterjee N, Yeager M, Welch R, Schoen RE, Yakochi L, Schatzkin A, Peters U
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17416760
C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.
D'Alessandris C, Lauro R, Presta I, Sesti G
Diabetologia. 2007
PubMed ID: 17279354
Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2.
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV
Cell Cycle. 2007
PubMed ID: 17374994
Divergent roles for IRS-1 and IRS-2 in breast cancer metastasis.
Gibson SL, Ma Z, Shaw LM
Cell Cycle. 2007
PubMed ID: 17361103
Oxygen tension regulates the stability of insulin receptor substrate-1 (IRS-1) through caspase-mediated cleavage.
Kang SG, Brown AL, Chung JH
J Biol Chem. 2007
PubMed ID: 17179152
[Effect of chronic ethanol intake on insulin receptor, insulin receptor subsrate-1 and phosphoinositide 3-kinase mRNA expression in skeletal muscle of rats].
Qu W, Hao L, Chen Y, Zhou S
Wei Sheng Yan Jiu. 2007
PubMed ID: 17555093
Insulin receptor substrate-1 regulates the transformed phenotype of BT-20 human mammary cancer cells.
Dalmizrak O, Wu A, Chen J, Sun H, Utama FE, Zambelli D, Tran TH, Rui H, Baserga R
Cancer Res. 2007
PubMed ID: 17332342
Insulin receptor substrates 1 and 2 but not Shc can activate the insulin receptor independent of insulin and induce proliferation in CHO-IR cells.
Niessen M, Jaschinski F, Item F, McNamara MP, Spinas GA, Trüb T
Exp Cell Res. 2007
PubMed ID: 17222824
Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.
Kuo AH, Stoica GE, Riegel AT, Wellstein A
Oncogene. 2007
PubMed ID: 16878150
LEPR, ADBR3, IRS-1 and 5-HTT genes polymorphisms do not associate with obesity.
Mergen H, Karaaslan C, Mergen M, Deniz Ozsoy E, Ozata M
Endocr J. 2007
PubMed ID: 17124363
IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.
Gunnell D, Lewis S, Wilkinson J, Georgieva L, Davey GS, Day IN, Holly JM, O'Donovan MC, Owen MJ, Kirov G, Zammit S
Am J Med Genet B Neuropsychiatr Genet. 2007
PubMed ID: 17044098
Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression.
Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF
Endocrinology. 2007
PubMed ID: 17038556
Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression.
Cleasby ME, Reinten TA, Cooney GJ, James DE, Kraegen EW
Mol Endocrinol. 2007
PubMed ID: 17021050
Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.
Zhande R, Zhang W, Zheng Y, Pendleton E, Li Y, Polakiewicz RD, Sun XJ
J Biol Chem. 2006
PubMed ID: 17068339
Reversal of diet-induced insulin resistance with a single bout of exercise in the rat: the role of PTP1B and IRS-1 serine phosphorylation.
Ropelle ER, Pauli JR, Prada PO, de Souza CT, Picardi PK, Faria MC, Cintra DE, Fernandes MF, Flores MB, Velloso LA, Saad MJ, Carvalheira JB
J Physiol. 2006
PubMed ID: 17008371
Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2.
Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV
Mol Cell Biol. 2006
PubMed ID: 17030631
Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis.
Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM
Mol Cell Biol. 2006
PubMed ID: 17030605
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
Insulin receptor substrate gene polymorphism is associated with obstructive sleep apnea syndrome in men.
Bayazit YA, Erdal ME, Yilmaz M, Ciftci TU, Soylemez F, Gokdoğan T, Kokturk O, Kemaloglu YK, Koybasioglu A
Laryngoscope. 2006
PubMed ID: 17075427
PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function.
Greene MW, Ruhoff MS, Roth RA, Kim JA, Quon MJ, Krause JA
Biochem Biophys Res Commun. 2006
PubMed ID: 16970908
Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase.
Beard KM, Lu H, Ho K, Fantus IG
Diabetes. 2006
PubMed ID: 17003331
Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5.
Fu Q, McKnight RA, Yu X, Callaway CW, Lane RH
FASEB J. 2006
PubMed ID: 16940436
Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress.
Bloch-Damti A, Potashnik R, Gual P, Le Marchand-Brustel Y, Tanti JF, Rudich A, Bashan N
Diabetologia. 2006
PubMed ID: 16896943
An association between a common variant (G972R) in the IRS-1 gene and sex hormone levels in post-menopausal breast cancer survivors.
Fan J, McKean-Cowdin R, Bernstein L, Stanczyk FZ, Li AX, Ballard-Barbash R, McTiernan A, Baumgartner R, Gilliland F
Breast Cancer Res Treat. 2006
PubMed ID: 16752222
Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5.
Su X, Lodhi IJ, Saltiel AR, Stahl PD
J Biol Chem. 2006
PubMed ID: 16880210
Identification of 14-3-3epsilon substrates from embryonic murine brain.
Ballif BA, Cao Z, Schwartz D, Carraway KL, Gygi SP
J Proteome Res. 2006
PubMed ID: 16944949
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis.
Shah OJ, Hunter T
Mol Cell Biol. 2006
PubMed ID: 16914728
Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation.
Nawaratne R, Gray A, Jørgensen CH, Downes CP, Siddle K, Sethi JK
Mol Endocrinol. 2006
PubMed ID: 16574739
siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.
Bouzakri K, Zachrisson A, Al-Khalili L, Zhang BB, Koistinen HA, Krook A, Zierath JR
Cell Metab. 2006
PubMed ID: 16814735
Low insulin-like growth factor binding protein-2 expression is responsible for increased insulin receptor substrate-1 phosphorylation in mesangial cells from mice susceptible to glomerulosclerosis.
Fornoni A, Rosenzweig SA, Lenz O, Rivera A, Striker GE, Elliot SJ
Endocrinology. 2006
PubMed ID: 16556765
Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes.
He F, Stephens JM
Biochem Biophys Res Commun. 2006
PubMed ID: 16616006
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.
Foukas LC, Claret M, Pearce W, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJ, Withers DJ, Vanhaesebroeck B
Nature. 2006
PubMed ID: 16625210
[Influence of chronic ethanol intake insulin sensitivity and IR, IRS-1, IRS-2 mRNA expression of liver in male rats]
Zhou SL, Hao LP, Chen YY, Qu W
Wei Sheng Yan Jiu. 2006
PubMed ID: 16921752
Ubiquitin ligase Cbl-b downregulates bone formation through suppression of IGF-I signaling in osteoblasts during denervation.
Suzue N, Nikawa T, Onishi Y, Yamada C, Hirasaka K, Ogawa T, Furochi H, Kosaka H, Ishidoh K, Gu H, Takeda S, Ishimaru N, Hayashi Y, Yamamoto H, Kishi K, Yasui N
J Bone Miner Res. 2006
PubMed ID: 16734387
Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor.
Nouaille S, Blanquart C, Zilberfarb V, Boute N, Perdereau D, Roix J, Burnol AF, Issad T
EMBO Rep. 2006
PubMed ID: 16582879
Effect of opioid mu-receptors activation on insulin signals damaged by tumor necrosis factor alpha in myoblast C2C12 cells.
Ko WC, Liu TP, Cheng JT, Tzeng TF, Liu IM
Neurosci Lett. 2006
PubMed ID: 16406665
Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes.
Danielsson A, Nystrom FH, Strålfors P
Biochem Biophys Res Commun. 2006
PubMed ID: 16516141
PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).
Slattery ML, Curtin K, Wolff R, Ma KN, Sweeney C, Murtaugh M, Potter JD, Levin TR, Samowitz W
Cancer Causes Control. 2006
PubMed ID: 16489531
Variation of the insulin receptor substrate gene (IRS-1) in African Pygmies and Bantus.
Battaggia C, Verginelli F, Palmirotta R, Mariani-Costantini R, Cama A, Destro-Bisol G
Diabetes Res Clin Pract. 2006
PubMed ID: 16233930
Polymorphisms in insulin-related genes predispose to specific KRAS2 and TP53 mutations in colon cancer.
Samowitz WS, Wolff RK, Ma KN, Andersen K, Caan B, Slattery ML
Mutat Res. 2006
PubMed ID: 16448675
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.
Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED
J Biol Chem. 2006
PubMed ID: 16418171
Association of insulin receptor substrate-1 G972R variant with baseline characteristics of the patients with gestational diabetes mellitus.
Tok EC, Ertunc D, Bilgin O, Erdal EM, Kaplanoglu M, Dilek S
Am J Obstet Gynecol. 2006
PubMed ID: 16522427
Association study of six activity SNPS in adrenal steroid hormone metabolism and IBM related genes with precocious puberty in Chinese girls.
Xin X, Xiao J, Luan X, Zhou Y, Lu D, Wei D, Yang S
Neuro Endocrinol Lett. 2006
PubMed ID: 16648810
Altered subcellular distribution of IRS-1 and IRS-3 is associated with defective Akt activation and GLUT4 translocation in insulin-resistant old rat adipocytes.
Villar M, Serrano R, Gallardo N, Carrascosa JM, Martinez C, Andrés A
Biochim Biophys Acta. 2006
PubMed ID: 16445997
Transformation by the simian virus 40 T antigen is regulated by IGF-I receptor and IRS-1 signaling.
DeAngelis T, Chen J, Wu A, Prisco M, Baserga R
Oncogene. 2006
PubMed ID: 16170362
[The influence of polymorphism the Gly972Arg variant insulin receptor substrate-1 (IRS-1) gene, and G-308A TNF-alpha gene on obesity and insulin resistance in children with obesity]
Pyrzak B, Wiśniewska A, Rymkiewicz-Kluczyńska B
Endokrynol Diabetol Chor Przemiany Materii Wieku R. 2006
PubMed ID: 17020651
The subcellular fractionation properties and function of insulin receptor substrate-1 (IRS-1) are independent of cytoskeletal integrity.
Thomas EC, Zhe Y, Molero JC, Schmitz-Peiffer C, Ramm G, James DE, Whitehead JP
Int J Biochem Cell Biol. 2006
PubMed ID: 16702017
Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism.
Lin TC, Yen JM, Gong KB, Kuo TC, Ku DC, Liang SF, Wu MJ
BMC Med Genet. 2006
PubMed ID: 16603055
Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
Dong X, Park S, Lin X, Copps K, Yi X, White MF
J Clin Invest. 2006
PubMed ID: 16374520
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation.
Tzatsos A, Kandror KV
Mol Cell Biol. 2006
PubMed ID: 16354680
Dihydrotestosterone inhibits insulin-stimulated cyclin D2 messenger ribonucleic acid expression in rat ovarian granulosa cells by reducing the phosphorylation of insulin receptor substrate-1.
Kayampilly PP, Menon KM
Endocrinology. 2006
PubMed ID: 16210359
T-antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS-1 and Rad51.
Trojanek J, Croul S, Ho T, Wang JY, Darbinyan A, Nowicki M, Del Valle L, Skorski T, Khalili K, Reiss K
J Cell Physiol. 2006
PubMed ID: 15965906
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.
Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI
J Clin Invest. 2005
PubMed ID: 16284649
A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.
Ruiz-Alcaraz AJ, Liu HK, Cuthbertson DJ, McManus EJ, Akhtar S, Lipina C, Morris AD, Petrie JR, Hundal HS, Sutherland C
Biochem J. 2005
PubMed ID: 16128672
The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal.
Weigert C, Hennige AM, Brischmann T, Beck A, Moeschel K, Schaüble M, Brodbeck K, Häring HU, Schleicher ED, Lehmann R
J Biol Chem. 2005
PubMed ID: 16129678
Genetic prediction of future type 2 diabetes.
Lyssenko V, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Saloranta C, Tuomi T, Groop L, Botnia Study Group
PLoS Med. 2005
PubMed ID: 17570749
Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controls.
Villuendas G, Botella-Carretero JI, Roldán B, Sancho J, Escobar-Morreale HF, San Millán JL
Hum Reprod. 2005
PubMed ID: 16037106
Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells.
Asano T, Yao Y, Shin S, McCubrey J, Abbruzzese JL, Reddy SA
Cancer Res. 2005
PubMed ID: 16230374
Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes.
Danielsson A, Ost A, Nystrom FH, Strålfors P
J Biol Chem. 2005
PubMed ID: 16129690
Molecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Turkish with type 2 diabetes mellitus.
Orkunoglu Suer FE, Mergen H, Bolu E, Ozata M
Endocr J. 2005
PubMed ID: 16284438
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.
Luo M, Reyna S, Wang L, Yi Z, Carroll C, Dong LQ, Langlais P, Weintraub ST, Mandarino LJ
Endocrinology. 2005
PubMed ID: 16020478
Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.
Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, Kobayashi M
Biochem Biophys Res Commun. 2005
PubMed ID: 16099428
Shp2 is required for protein kinase C-dependent phosphorylation of serine 307 in insulin receptor substrate-1.
Müssig K, Staiger H, Fiedler H, Moeschel K, Beck A, Kellerer M, Häring HU
J Biol Chem. 2005
PubMed ID: 16055440
Suppression of aging in mice by the hormone Klotho.
Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M
Science. 2005
PubMed ID: 16123266
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Identification of phosphorylation sites in insulin receptor substrate-1 by hypothesis-driven high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
Yi Z, Luo M, Carroll CA, Weintraub ST, Mandarino LJ
Anal Chem. 2005
PubMed ID: 16131083
Impact of common polymorphisms in candidate genes for insulin resistance and obesity on weight loss of morbidly obese subjects after laparoscopic adjustable gastric banding and hypocaloric diet.
Sesti G, Perego L, Cardellini M, Andreozzi F, Ricasoli C, Vedani P, Guzzi V, Marchi M, Paganelli M, Ferla G, Pontiroli AE, Hribal ML, Folli F
J Clin Endocrinol Metab. 2005
PubMed ID: 15985484
Functional significance of type 1 insulin-like growth factor-mediated nuclear translocation of the insulin receptor substrate-1 and beta-catenin.
Chen J, Wu A, Sun H, Drakas R, Garofalo C, Cascio S, Surmacz E, Baserga R
J Biol Chem. 2005
PubMed ID: 15967802
Association of Gly972Arg variant of insulin receptor substrate-1 with metabolic features in women with polycystic ovary syndrome.
Dilek S, Ertunc D, Tok EC, Erdal EM, Aktas A
Fertil Steril. 2005
PubMed ID: 16084882
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex.
Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC
J Cell Biol. 2005
PubMed ID: 16043515
Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption.
Zheng Y, Yamada H, Sakamoto K, Horita S, Kunimi M, Endo Y, Li Y, Tobe K, Terauchi Y, Kadowaki T, Seki G, Fujita T
J Am Soc Nephrol. 2005
PubMed ID: 15975995
Insulin-like growth factor pathway polymorphisms associated with body size in Hispanic and non-Hispanic white women.
Sweeney C, Murtaugh MA, Baumgartner KB, Byers T, Giuliano AR, Herrick JS, Wolff R, Caan BJ, Slattery ML
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 16030120
Insulin receptor substrates-1 and -2 are both depleted but via different mechanisms after down-regulation of glucose transport in rat adipocytes.
Renström F, Burén J, Eriksson JW
Endocrinology. 2005
PubMed ID: 15845625
Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk.
Neuhausen SL, Slattery ML, Garner CP, Ding YC, Hoffman M, Brothman AR
Prostate. 2005
PubMed ID: 15678496
Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin
Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ
J Biol Chem. 2005
PubMed ID: 15849359
Identification of a NPXY motif in growth factor receptor-bound protein 14 (Grb14) and its interaction with the phosphotyrosine-binding (PTB) domain of IRS-1.
Rajala RV, Chan MD
Biochemistry. 2005
PubMed ID: 15924411
Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II.
Taniyama Y, Hitomi H, Shah A, Alexander RW, Griendling KK
Arterioscler Thromb Vasc Biol. 2005
PubMed ID: 15802620
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H
Mol Cell Proteomics. 2005
PubMed ID: 15778465
Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice.
Yamaguchi M, Ogata N, Shinoda Y, Akune T, Kamekura S, Terauchi Y, Kadowaki T, Hoshi K, Chung UI, Nakamura K, Kawaguchi H
Endocrinology. 2005
PubMed ID: 15718274
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.
Huang C, Thirone AC, Huang X, Klip A
J Biol Chem. 2005
PubMed ID: 15764603
Genetic determinants of insulin action in polycystic ovary syndrome.
Haap M, Machicao F, Stefan N, Thamer C, Tschritter O, Schnuck F, Wallwiener D, Stumvoll M, Häring HU, Fritsche A
Exp Clin Endocrinol Diabetes. 2005
PubMed ID: 15926113
The importance of IRS-1 Gly972Arg polymorphism in evaluating the response to metformin treatment in polycystic ovary syndrome.
Ertunc D, Tok EC, Aktas A, Erdal EM, Dilek S
Hum Reprod. 2005
PubMed ID: 15665022
Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells.
Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, Kaneki M
J Biol Chem. 2005
PubMed ID: 15805118
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinänen-Kiukaanniemi S, Laakso M
Mol Genet Metab. 2005
PubMed ID: 15781195
Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain.
Csehi SB, Mathieu S, Seifert U, Lange A, Zweyer M, Wernig A, Adam D
Biochem Biophys Res Commun. 2005
PubMed ID: 15721320
Depletion of mitochondrial DNA causes impaired glucose utilization and insulin resistance in L6 GLUT4myc myocytes.
Park SY, Choi GH, Choi HI, Ryu J, Jung CY, Lee W
J Biol Chem. 2005
PubMed ID: 15764607
RACK1-mediated integration of adhesion and insulin-like growth factor I (IGF-I) signaling and cell migration are defective in cells expressing an IGF-I receptor mutated at tyrosines 1250 and 1251.
Kiely PA, Leahy M, O'Gorman D, O'Connor R
J Biol Chem. 2005
PubMed ID: 15611085
Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism.
Taniguchi CM, Ueki K, Kahn R
J Clin Invest. 2005
PubMed ID: 15711641
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.
Ueno M, Carvalheira JB, Tambascia RC, Bezerra RM, Amaral ME, Carneiro EM, Folli F, Franchini KG, Saad MJ
Diabetologia. 2005
PubMed ID: 15692808
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.
Khamzina L, Veilleux A, Bergeron S, Marette A
Endocrinology. 2005
PubMed ID: 15604215
Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion.
Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Höer NF, Boschero AC, Saad MJ
Endocrinology. 2005
PubMed ID: 15591151
Short-term in vivo inhibition of insulin receptor substrate-1 expression leads to insulin resistance, hyperinsulinemia, and increased adiposity.
Araújo EP, De Souza CT, Gasparetti AL, Ueno M, Boschero AC, Saad MJ, Velloso LA
Endocrinology. 2005
PubMed ID: 15550510
Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation.
McGettrick AJ, Feener EP, Kahn CR
J Biol Chem. 2005
PubMed ID: 15590636
Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.
Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W
Biochem Biophys Res Commun. 2005
PubMed ID: 15629149
Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling.
Liberman Z, Eldar-Finkelman H
J Biol Chem. 2005
PubMed ID: 15574412
Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells.
Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF
J Neurosci. 2005
PubMed ID: 15689562
Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess.
Witchel SF, Kahsar-Miller M, Aston CE, White C, Azziz R
Fertil Steril. 2005
PubMed ID: 15705377
Reduction of adiposity with prolonged growth hormone treatment in old obese rats: effects on glucose handling and early insulin signaling.
Johansen T, Laurino C, Barreca A, Malmlöf K
Growth Horm IGF Res. 2005
PubMed ID: 15701573
The loss of glypican-3 induces alterations in Wnt signaling.
Song HH, Shi W, Xiang YY, Filmus J
J Biol Chem. 2005
PubMed ID: 15537637
[Clinical genetic determinants of carbohydrate metabolism disturbances in patients with hypertension and excessive weight]
Kobalava ZhD, Nosikov VV, Tolkacheva VV, Chernysheva GV, Volkova EG, Shustov SB, Ignat'ev IV, Moiseev VS
Kardiologiia. 2005
PubMed ID: 15940190
[Effects of chromium supplementation on IRS-1 expression of skeletal muscle in diabetic rats]
Sun Z, Wu YT, Che SP, Wang X
Wei Sheng Yan Jiu. 2005
PubMed ID: 15862035
Searching QTL by gene expression: analysis of diabesity.
Brown AC, Olver WI, Donnelly CJ, May ME, Naggert JK, Shaffer DJ, Roopenian DC
BMC Genet. 2005
PubMed ID: 15760467
[Clinicogenetic aspects of carbohydrate metabolism disorders and efficacy of their correction with moxonidine and metformine in patients with arterial hypertension]
Kobalava ZhD, Tolkacheva VV, Ignat'ev IV, Glezer MG, Kuzin AI, Karpov IuA, Konradi AO, Zheleznykh EA
Ter Arkh. 2005
PubMed ID: 15759454
Insulin resistance in human adipocytes occurs downstream of IRS1 after surgical cell isolation but at the level of phosphorylation of IRS1 in type 2 diabetes.
Danielsson A, Ost A, Lystedt E, Kjolhede P, Gustavsson J, Nystrom FH, Strålfors P
FEBS J. 2005
PubMed ID: 15634339
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Substrate-trapping techniques in the identification of cellular PTP targets.
Blanchetot C, Chagnon M, Dubé N, Hallé M, Tremblay ML
Methods. 2005
PubMed ID: 15588985
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.
Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV
Biochemistry. 2004
PubMed ID: 15581362
Retinoic acid mediates degradation of IRS-1 by the ubiquitin-proteasome pathway, via a PKC-dependant mechanism.
del Rincón SV, Guo Q, Morelli C, Shiu HY, Surmacz E, Miller WH
Oncogene. 2004
PubMed ID: 15516986
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Zeggini E, Parkinson J, Halford S, Owen KR, Frayling TM, Walker M, Hitman GA, Levy JC, Sampson MJ, Feskens EJ, Hattersley AT, McCarthy MI
Diabetes. 2004
PubMed ID: 15561966
Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.
Florez JC, Sjögren M, Burtt N, Orho-Melander M, Schayer S, Sun M, Almgren P, Lindblad U, Tuomi T, Gaudet D, Hudson TJ, Daly MJ, Ardlie KG, Hirschhorn JN, Altshuler D, Groop L
Diabetes. 2004
PubMed ID: 15561965
The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer.
Wagner K, Hemminki K, Grzybowska E, Klaes R, Butkiewicz D, Pamula J, Pekala W, Zientek H, Mielzynska D, Siwinska E, Försti A
Carcinogenesis. 2004
PubMed ID: 15308584
Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways.
Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N
Exp Gerontol. 2004
PubMed ID: 15582274
Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.
Liu YF, Herschkovitz A, Boura-Halfon S, Ronen D, Paz K, Leroith D, Zick Y
Mol Cell Biol. 2004
PubMed ID: 15485932
Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101).
Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD
J Biol Chem. 2004
PubMed ID: 15364919
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin.
Duan C, Li M, Rui L
J Biol Chem. 2004
PubMed ID: 15316008
DNA polymorphism analysis of candidate genes for type 2 diabetes mellitus in a Mexican ethnic group.
Flores-Martínez SE, Islas-Andrade S, Machorro-Lazo MV, Revilla MC, Juárez RE, Mújica-López KI, Morán-Moguel MC, López-Cardona MG, Sánchez-Corona J
Ann Genet. 2004
PubMed ID: 15581831
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Insulin secretion in women who have polycystic ovary syndrome and carry the Gly972Arg variant of insulin receptor substrate-1 in response to a high-glycemic or low-glycemic carbohydrate load.
Sir-Petermann T, Angel B, Maliqueo M, Santos JL, Riesco MV, Toloza H, Pérez-Bravo F
Nutrition. 2004
PubMed ID: 15474880
beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1.
Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM
Mol Cell Biol. 2004
PubMed ID: 15456867
Tissue-specific differences in activation of atypical protein kinase C and protein kinase B in muscle, liver, and adipocytes of insulin receptor substrate-1 knockout mice.
Sajan MP, Standaert ML, Miura A, Kahn CR, Farese RV
Mol Endocrinol. 2004
PubMed ID: 15256535
Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis.
Franch HA, Raissi S, Wang X, Zheng B, Bailey JL, Price SR
Am J Physiol Renal Physiol. 2004
PubMed ID: 15161606
Nuclear insulin receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.
Morelli C, Garofalo C, Sisci D, del Rincon S, Cascio S, Tu X, Vecchione A, Sauter ER, Miller WH, Surmacz E
Oncogene. 2004
PubMed ID: 15318176
Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.
Hayashi K, Shibata K, Morita T, Iwasaki K, Watanabe M, Sobue K
J Biol Chem. 2004
PubMed ID: 15272025
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies.
Shah OJ, Wang Z, Hunter T
Curr Biol. 2004
PubMed ID: 15380067
The G972R variant of the insulin receptor substrate-1 (IRS-1) gene is associated with insulin resistance in "uncomplicated" obese subjects evaluated by hyperinsulinemic-euglycemic clamp.
Baroni MG, Leonetti F, Sentinelli F, Romeo S, Filippi E, Fanelli M, Ribaudo MC, Zappaterreno A, Fallarino M, Di Mario U
J Endocrinol Invest. 2004
PubMed ID: 15636429
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T
Curr Biol. 2004
PubMed ID: 15324660
Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.
Werner ED, Lee J, Hansen L, Yuan M, Shoelson SE
J Biol Chem. 2004
PubMed ID: 15199052
Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats.
Barreiro GC, Prattali RR, Caliseo CT, Fugiwara FY, Ueno M, Prada PO, Velloso LA, Saad MJ, Carvalheira JB
Biochem Biophys Res Commun. 2004
PubMed ID: 15240146
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.
Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S, Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I, Downes CP, Lamb RF
J Cell Biol. 2004
PubMed ID: 15249583
Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.
Slattery ML, Samowitz W, Curtin K, Ma KN, Hoffman M, Caan B, Neuhausen S
Cancer Epidemiol Biomarkers Prev. 2004
PubMed ID: 15247132
Impaired endothelial function in never-treated hypertensive subjects carrying the Arg972 polymorphism in the insulin receptor substrate-1 gene.
Perticone F, Sciacqua A, Scozzafava A, Ventura G, Laratta E, Pujia A, Federici M, Lauro R, Sesti G
J Clin Endocrinol Metab. 2004
PubMed ID: 15240653
ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
Motegi A, Fujimoto J, Kotani M, Sakuraba H, Yamamoto T
J Cell Sci. 2004
PubMed ID: 15226403
The insulin receptor substrate-1 Gly972Arg polymorphism is not associated with Type 2 diabetes mellitus in two population-based studies.
van Dam RM, Hoebee B, Seidell JC, Schaap MM, Blaak EE, Feskens EJ
Diabet Med. 2004
PubMed ID: 15209769
Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.
Yen HW, Jakimiuk AJ, Munir I, Magoffin DA
Mol Hum Reprod. 2004
PubMed ID: 15155816
Quantifying carbon sources for de novo lipogenesis in wild-type and IRS-1 knockout brown adipocytes.
Yoo H, Stephanopoulos G, Kelleher JK
J Lipid Res. 2004
PubMed ID: 15102881
Control of cell size through phosphorylation of upstream binding factor 1 by nuclear phosphatidylinositol 3-kinase.
Drakas R, Tu X, Baserga R
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15197263
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1.
Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED, Häring HU, Lehmann R
J Biol Chem. 2004
PubMed ID: 15069075
Caspase-mediated Cleavage of Insulin Receptor Substrate.
Green KA, Naylor MJ, Lowe ET, Wang P, Marshman E, Streuli CH
J Biol Chem. 2004
PubMed ID: 15069074
Colocalization of insulin receptor and insulin receptor substrate-1 to caveolae in primary human adipocytes. Cholesterol depletion blocks insulin signalling for metabolic and mitogenic control.
Karlsson M, Thorn H, Danielsson A, Stenkula KG, Ost A, Gustavsson J, Nystrom FH, Strålfors P
Eur J Biochem. 2004
PubMed ID: 15182363
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
Ueki K, Kondo T, Kahn CR
Mol Cell Biol. 2004
PubMed ID: 15169905
The Arg972 variant in insulin receptor substrate-1 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
Sesti G, Marini MA, Cardellini M, Sciacqua A, Frontoni S, Andreozzi F, Irace C, Lauro D, Gnasso A, Federici M, Perticone F, Lauro R
Diabetes Care. 2004
PubMed ID: 15161794
Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells.
Andreozzi F, Laratta E, Sciacqua A, Perticone F, Sesti G
Circ Res. 2004
PubMed ID: 15044323
Cellular growth inhibition by TGF-beta1 involves IRS proteins.
Huang SS, Leal SM, Chen CL, Liu IH, Huang JS
FEBS Lett. 2004
PubMed ID: 15135063
Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to Type 2 diabetes. The Finnish Diabetes Prevention Study.
Laukkanen O, Pihlajamäki J, Lindström J, Eriksson J, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M, Finnish Diabetes Prevention Study Group
Diabetologia. 2004
PubMed ID: 15127203
Impairment of bone healing by insulin receptor substrate-1 deficiency.
Shimoaka T, Kamekura S, Chikuda H, Hoshi K, Chung UI, Akune T, Maruyama Z, Komori T, Matsumoto M, Ogawa W, Terauchi Y, Kadowaki T, Nakamura K, Kawaguchi H
J Biol Chem. 2004
PubMed ID: 14736890
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS
Oncogene. 2004
PubMed ID: 14968112
Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation.
Carlson CJ, White MF, Rondinone CM
Biochem Biophys Res Commun. 2004
PubMed ID: 15020250
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
IGF-I regulates caveolin 1 and IRS1 interaction in caveolae.
Panetta D, Biedi C, Repetto S, Cordera R, Maggi D
Biochem Biophys Res Commun. 2004
PubMed ID: 15003536
Differential roles of insulin receptor substrates in brown adipocyte differentiation.
Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR
Mol Cell Biol. 2004
PubMed ID: 14966273
A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation.
Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH
J Biol Chem. 2004
PubMed ID: 14668342
Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta.
Greene MW, Morrice N, Garofalo RS, Roth RA
Biochem J. 2004
PubMed ID: 14583092
Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.
Le HT, Ponniah S, Pallen CJ
Biochem Biophys Res Commun. 2004
PubMed ID: 14733908
Role of insulin receptor substrates and protein kinase C-zeta in vascular permeability factor/vascular endothelial growth factor expression in pancreatic cancer cells.
Neid M, Datta K, Stephan S, Khanna I, Pal S, Shaw L, White M, Mukhopadhyay D
J Biol Chem. 2004
PubMed ID: 14604996
Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts.
Choi WS, Sung CK
J Recept Signal Transduct Res. 2004
PubMed ID: 15344880
Lack of Arg972 polymorphism in the IRS1 gene in Parakanã Brazilian Indians.
Bezerra RM, Chadid TT, Altemani CM, Sales TS, Menezes R, Soares MC, Saad ST, Saad MJ
Hum Biol. 2004
PubMed ID: 15222685
Deficiency of insulin receptor substrate-1 impairs skeletal growth through early closure of epiphyseal cartilage.
Hoshi K, Ogata N, Shimoaka T, Terauchi Y, Kadowaki T, Kenmotsu S, Chung UI, Ozawa H, Nakamura K, Kawaguchi H
J Bone Miner Res. 2004
PubMed ID: 14969391
Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling.
Giraud J, Leshan R, Lee YH, White MF
J Biol Chem. 2004
PubMed ID: 14623899
IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi.
Ferreira IA, Eybrechts KL, Mocking AI, Kroner C, Akkerman JW
J Biol Chem. 2004
PubMed ID: 14602724
G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells.
Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D, Cardellini M, Romano M, Sesti G, Lauro R, Consoli A
Circulation. 2004
PubMed ID: 14707024
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation.
Kaiser C, James SR
BMC Biol. 2004
PubMed ID: 15522123
Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings.
Sánchez-Corona J, Flores-Martínez SE, Machorro-Lazo MV, Galaviz-Hernández C, Morán-Moguel MC, Perea FJ, Mújica-López KI, Vargas-Ancona L, Laviada-Molina HA, Fernández V, Pardío J, Arroyo P, Barrera H, Hanson RL
Diabetes Res Clin Pract. 2004
PubMed ID: 14693412
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.
Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR
Mol Cell Biol. 2004
PubMed ID: 14673165
Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.
Abate N, Carulli L, Cabo-Chan A, Chandalia M, Snell PG, Grundy SM
J Clin Endocrinol Metab. 2003
PubMed ID: 14671192
The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians.
Kovacs P, Hanson RL, Lee YH, Yang X, Kobes S, Permana PA, Bogardus C, Baier LJ
Diabetes. 2003
PubMed ID: 14633864
The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance.
Carvalheira JB, Calegari VC, Zecchin HG, Nadruz W, Guimarães RB, Ribeiro EB, Franchini KG, Velloso LA, Saad MJ
Endocrinology. 2003
PubMed ID: 12960006
ATP-sensitive K+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling.
Minami K, Morita M, Saraya A, Yano H, Terauchi Y, Miki T, Kuriyama T, Kadowaki T, Seino S
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12933351
Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase C alpha-mediated mechanism.
Miele C, Riboulet A, Maitan MA, Oriente F, Romano C, Formisano P, Giudicelli J, Beguinot F, Van Obberghen E
J Biol Chem. 2003
PubMed ID: 12970360
Overexpression of Fer increases the association of tyrosine-phosphorylated IRS-1 with P85 phosphatidylinositol kinase via SH2 domain of Fer in transfected cells.
Iwanishi M
Biochem Biophys Res Commun. 2003
PubMed ID: 14623341
Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.
Arribas M, Valverde AM, Benito M
J Biol Chem. 2003
PubMed ID: 12944402
Subcellular localization of IRS-1 in cell proliferation and differentiation.
Tu X, Wu A, Maiorana A, Baserga R
Horm Metab Res. 2003
PubMed ID: 14710352
Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant.
Jellema A, Mensink RP, Kromhout D, Saris WH, Feskens EJ
Atherosclerosis. 2003
PubMed ID: 14642408
MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.
Gual P, Grémeaux T, Gonzalez T, Le Marchand-Brustel Y, Tanti JF
Diabetologia. 2003
PubMed ID: 14579029
Role of the insulin-like growth factor I/insulin receptor substrate 1 axis in Rad51 trafficking and DNA repair by homologous recombination.
Trojanek J, Ho T, Del Valle L, Nowicki M, Wang JY, Lassak A, Peruzzi F, Khalili K, Skorski T, Reiss K
Mol Cell Biol. 2003
PubMed ID: 14559999
Phosphorylation of insulin receptor substrate-1 serine 307 correlates with JNK activity in atrophic skeletal muscle.
Hilder TL, Tou JC, Grindeland RE, Wade CE, Graves LM
FEBS Lett. 2003
PubMed ID: 14550547
Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation.
Widberg CH, Bryant NJ, Girotti M, Rea S, James DE
J Biol Chem. 2003
PubMed ID: 12832401
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A
Genesis. 2003
PubMed ID: 14502571
Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development.
Khamzina L, Gruppuso PA, Wands JR
Gastroenterology. 2003
PubMed ID: 12891559
Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells.
Tu X, Baffa R, Luke S, Prisco M, Baserga R
Exp Cell Res. 2003
PubMed ID: 12878164
Modulation of IR/PTP1B interaction and downstream signaling in insulin sensitive tissues of MSG-rats.
Hirata AE, Alvarez-Rojas F, Carvalheira JB, Carvalho CR, Dolnikoff MS, Abdalla Saad MJ
Life Sci. 2003
PubMed ID: 12850498
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.
Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF
J Biol Chem. 2003
PubMed ID: 12730242
TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells.
Mincione G, Esposito DL, Di Marcantonio MC, Piccirelli A, Cama A, Colletta G
Exp Cell Res. 2003
PubMed ID: 12837295
Nuclear matrix association of insulin receptor and IRS-1 by insulin in osteoblast-like UMR-106 cells.
Seol KC, Kim SJ
Biochem Biophys Res Commun. 2003
PubMed ID: 12821126
[Polymorphism of insulin receptor substrate-1 gene in patients with coronary heart diseases]
Liu R, Bai H, Liu Y, Li X, Huang M, Deng J, Liu B
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003
PubMed ID: 12910680
The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.
Marini MA, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D'Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R, Sesti G
J Clin Endocrinol Metab. 2003
PubMed ID: 12843189
Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies.
Jellema A, Zeegers MP, Feskens EJ, Dagnelie PC, Mensink RP
Diabetologia. 2003
PubMed ID: 12819898
Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells.
Morelli C, Garofalo C, Bartucci M, Surmacz E
Oncogene. 2003
PubMed ID: 12821935
Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury.
Kubota T, Kubota N, Moroi M, Terauchi Y, Kobayashi T, Kamata K, Suzuki R, Tobe K, Namiki A, Aizawa S, Nagai R, Kadowaki T, Yamaguchi T
Circulation. 2003
PubMed ID: 12810606
Regulation of insulin receptor substrate-1 in the liver, skeletal muscle and adipose tissue of rats throughout pregnancy.
González C, Alonso A, Fernández R, Patterson AM
Gynecol Endocrinol. 2003
PubMed ID: 12857426
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H
Diabetes. 2003
PubMed ID: 12765939
Constitutive over-expression of the insulin receptor substrate-1 causes functional up-regulation of Fas receptor.
Wiedmann M, Tamaki S, Silberman R, de la Monte SM, Cousens L, Wands JR
J Hepatol. 2003
PubMed ID: 12763374
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL
Endocrinology. 2003
PubMed ID: 12746333
Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts.
Wu A, Sciacca L, Baserga R
J Cell Physiol. 2003
PubMed ID: 12704655
Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2.
Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M
J Biol Chem. 2003
PubMed ID: 12624099
Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
Pirola L, Bonnafous S, Johnston AM, Chaussade C, Portis F, Van Obberghen E
J Biol Chem. 2003
PubMed ID: 12594228
IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.
Potashnik R, Bloch-Damti A, Bashan N, Rudich A
Diabetologia. 2003
PubMed ID: 12750770
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T
Clin Pharmacol Ther. 2003
PubMed ID: 12732844
A stromal cell-derived membrane protein that supports hematopoietic stem cells.
Ueno H, Sakita-Ishikawa M, Morikawa Y, Nakano T, Kitamura T, Saito M
Nat Immunol. 2003
PubMed ID: 12665856
A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
Esposito DL, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon MJ, Cama A
J Clin Endocrinol Metab. 2003
PubMed ID: 12679424
The role of PI3K in immune cells.
Koyasu S
Nat Immunol. 2003
PubMed ID: 12660731
Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes.
Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M
J Biol Chem. 2003
PubMed ID: 12525499
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation.
Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA
J Biol Chem. 2003
PubMed ID: 12510059
Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F
J Biol Chem. 2003
PubMed ID: 12493740
Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine gamma-herpesvirus 68.
Elsawa SF, Taylor W, Petty CC, Marriott I, Weinstock JV, Bost KL
J Immunol. 2003
PubMed ID: 12594288
Insulin-like growth factor I receptor signaling and nuclear translocation of insulin receptor substrates 1 and 2.
Sun H, Tu X, Prisco M, Wu A, Casiburi I, Baserga R
Mol Endocrinol. 2003
PubMed ID: 12554758
[Relationship between the mutation of insulin receptor substrate-1 gene 3'untranslated region and type 2 diabetes in the Chinese]
Chen SH, Gu YP, Zeng WM
Hunan Yi Ke Da Xue Xue Bao. 2003
PubMed ID: 12934392
Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.
Hammarstedt A, Jansson PA, Wesslau C, Yang X, Smith U
Biochem Biophys Res Commun. 2003
PubMed ID: 12565902
MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression.
Yujiri T, Nawata R, Takahashi T, Sato Y, Tanizawa Y, Kitamura T, Oka Y
J Biol Chem. 2003
PubMed ID: 12458213
Intima media thickness of carotid arteries is reduced in heterozygous carriers of the Gly972Arg variant in the insulin receptor substrate-1 gene.
Hölzl B, Iglseder B, Stadlmayr A, Hedegger M, Moré E, Reiter R, Sandhofer F, Paulweber B
Eur J Clin Invest. 2003
PubMed ID: 12588284
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.
Lee YH, Giraud J, Davis RJ, White MF
J Biol Chem. 2003
PubMed ID: 12417588
BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells.
Traina F, Carvalheira JB, Saad MJ, Costa FF, Saad ST
FEBS Lett. 2003
PubMed ID: 12560071
Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells.
Jiang G, Dallas-Yang Q, Liu F, Moller DE, Zhang BB
J Biol Chem. 2003
PubMed ID: 12409308
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle.
Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI
J Biol Chem. 2002
PubMed ID: 12006582
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Reciprocal feedback regulation of insulin receptor and insulin receptor substrate tyrosine phosphorylation by phosphoinositide 3-kinase in primary adipocytes.
Hers I, Bell CJ, Poole AW, Jiang D, Denton RM, Schaefer E, Tavaré JM
Biochem J. 2002
PubMed ID: 12220227
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J
J Biol Chem. 2002
PubMed ID: 12351658
Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells.
Bompard G, Puech C, Prébois C, Vignon F, Freiss G
J Biol Chem. 2002
PubMed ID: 12354757
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Increased frequency of the G972R variant of the insulin receptor substrate-1 (irs-1) gene among girls with a history of precocious pubarche.
Ibáñez L, Marcos MV, Potau N, White C, Aston CE, Witchel SF
Fertil Steril. 2002
PubMed ID: 12477526
Increased insulin resistance in obese children who have both 972 IRS-1 and 1057 IRS-2 polymorphisms.
Le Fur S, Le Stunff C, Bougnères P
Diabetes. 2002
PubMed ID: 12475767
Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I. Effect on ribosomal RNA synthesis.
Tu X, Batta P, Innocent N, Prisco M, Casaburi I, Belletti B, Baserga R
J Biol Chem. 2002
PubMed ID: 12202493
The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway.
Senthil D, Ghosh Choudhury G, Bhandari BK, Kasinath BS
Biochem J. 2002
PubMed ID: 12153400
Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications.
Chang Q, Li Y, White MF, Fletcher JA, Xiao S
Cancer Res. 2002
PubMed ID: 12414625
Insulin receptor substrate-1 is present in hepatocyte nuclei from intact rats.
Boylan JM, Gruppuso PA
Endocrinology. 2002
PubMed ID: 12399410
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2.
Rui L, Yuan M, Frantz D, Shoelson S, White MF
J Biol Chem. 2002
PubMed ID: 12228220
Differential regulation of gene expression and insulin-induced activation of phosphodiesterase 3B in adipocytes of lean insulin-resistant IRS-1 (-/-) mice.
Hasegawa M, Tang Y, Osawa H, Onuma H, Nishimiya T, Ochi M, Terauchi Y, Kadowaki T, Makino H
Diabetes Res Clin Pract. 2002
PubMed ID: 12213348
Common variants in the lipoprotein lipase gene, but not those in the insulin receptor substrate-1, the beta3-adrenergic receptor, and the intestinal fatty acid binding protein-2 genes, influence the lipid phenotypic expression in familial combined hyperli
Campagna F, Montali A, Baroni MG, Maria AT, Ricci G, Antonini R, Verna R, Arca M
Metabolism. 2002
PubMed ID: 12370850
Genetic variants of insulin receptor substrate-1 (IRS-1) in syndromes of severe insulin resistance. Functional analysis of Ala513Pro and Gly1158Glu IRS-1.
Berger D, Barroso I, Soos M, Yeo G, Schafer AJ, O'Rahilly S, Whitehead JP
Diabet Med. 2002
PubMed ID: 12358865
Relationship of insulin receptor substrate-1 and -2 genotypes to phenotypic features of polycystic ovary syndrome.
Ehrmann DA, Tang X, Yoshiuchi I, Cox NJ, Bell GI
J Clin Endocrinol Metab. 2002
PubMed ID: 12213887
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Scheid MP, Marignani PA, Woodgett JR
Mol Cell Biol. 2002
PubMed ID: 12167717
Nuclear translocation of insulin receptor substrate-1 by the simian virus 40 T antigen and the activated type 1 insulin-like growth factor receptor.
Prisco M, Santini F, Baffa R, Liu M, Drakas R, Wu A, Baserga R
J Biol Chem. 2002
PubMed ID: 12063262
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.
Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH
Oncogene. 2002
PubMed ID: 12173038
Nitric oxide regulates oestrogen-activated signalling pathways at multiple levels through cyclic GMP-dependent recruitment of insulin receptor substrate 1.
Falcone S, Mauro L, de Rose G, Paolucci C, Sciorati C, Ando S, Clementi E
Biochem J. 2002
PubMed ID: 11978177
In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents.
Qiao LY, Zhande R, Jetton TL, Zhou G, Sun XJ
J Biol Chem. 2002
PubMed ID: 12006586
Deficient expression of insulin receptor substrate-1 (IRS-1) fails to block insulin-like growth factor-I (IGF-I) stimulation of brain growth and myelination.
Ye P, Li L, Lund PK, D'Ercole AJ
Brain Res Dev Brain Res. 2002
PubMed ID: 12101028
Overexpression of insulin receptor substrate-1, but not insulin receptor substrate-2, protects a T cell hybridoma from activation-induced cell death.
Li L, Qi X, Williams M, Shi Y, Keegan AD
J Immunol. 2002
PubMed ID: 12055235
Regulation of IRS-1/SHP2 interaction and AKT phosphorylation in animal models of insulin resistance.
Lima MH, Ueno M, Thirone AC, Rocha EM, Carvalho CR, Saad MJ
Endocrine. 2002
PubMed ID: 12166618
Differential effects of tumor necrosis factor-alpha on protein kinase C isoforms alpha and delta mediate inhibition of insulin receptor signaling.
Rosenzweig T, Braiman L, Bak A, Alt A, Kuroki T, Sampson SR
Diabetes. 2002
PubMed ID: 12031982
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Insulin receptor substrate 4 associates with the protein IRAS.
Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE
J Biol Chem. 2002
PubMed ID: 11912194
Insulin receptor substrate 1 translocation to the nucleus by the human JC virus T-antigen.
Lassak A, Del Valle L, Peruzzi F, Wang JY, Enam S, Croul S, Khalili K, Reiss K
J Biol Chem. 2002
PubMed ID: 11877394
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events.
Hamer I, Foti M, Emkey R, Cordier-Bussat M, Philippe J, De Meyts P, Maeder C, Kahn CR, Carpentier JL
Diabetologia. 2002
PubMed ID: 12107746
Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10.
Stumvoll M, Wahl HG, Machicao F, Häring H
Diabetologia. 2002
PubMed ID: 12107745
Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein.
Ichimura T, Wakamiya-Tsuruta A, Itagaki C, Taoka M, Hayano T, Natsume T, Isobe T
Biochemistry. 2002
PubMed ID: 11969417
14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1.
Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z
Mol Endocrinol. 2002
PubMed ID: 11875115
The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns.
Bezerra RM, de Castro V, Sales T, Passini R, Marba ST, Saad ST, Saad MJ
Diabetes Care. 2002
PubMed ID: 11874945
Variations in insulin secretion in carriers of gene variants in IRS-1 and -2.
't Hart LM, Nijpels G, Dekker JM, Maassen JA, Heine RJ, van Haeften TW
Diabetes. 2002
PubMed ID: 11872698
Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.
Begum N, Sandu OA, Ito M, Lohmann SM, Smolenski A
J Biol Chem. 2002
PubMed ID: 11739394
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action.
Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF
J Biol Chem. 2002
PubMed ID: 11606564
Absence of insulin receptor substrate-1 expression does not alter GLUT1 or GLUT4 abundance or contraction-stimulated glucose uptake by mouse skeletal muscle.
Dumke CL, Wetter AC, Arias EB, Kahn CR, Cartee GD
Horm Metab Res. 2001
PubMed ID: 11753753
Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Favelyukis S, Till JH, Hubbard SR, Miller WT
Nat Struct Biol. 2001
PubMed ID: 11694888
Sam68 is a docking protein linking GAP and PI3K in insulin receptor signaling.
Sánchez-Margalet V, Najib S
Mol Cell Endocrinol. 2001
PubMed ID: 11604231
Phosphorylation of PTP1B at Ser(50) by Akt impairs its ability to dephosphorylate the insulin receptor.
Ravichandran LV, Chen H, Li Y, Quon MJ
Mol Endocrinol. 2001
PubMed ID: 11579209
Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.
El Mkadem SA, Lautier C, Macari F, Molinari N, Lefèbvre P, Renard E, Gris JC, Cros G, Daurès JP, Bringer J, White MF, Grigorescu F
Diabetes. 2001
PubMed ID: 11522686
E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway.
Richards RG, Klotz DM, Bush MR, Walmer DK, DiAugustine RP
Endocrinology. 2001
PubMed ID: 11517161
Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
Tsuji Y, Kaburagi Y, Terauchi Y, Satoh S, Kubota N, Tamemoto H, Kraemer FB, Sekihara H, Aizawa S, Akanuma Y, Tobe K, Kimura S, Kadowaki T
Diabetes. 2001
PubMed ID: 11375348
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.
Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11287630
Candidate gene analysis in premature pubarche and adolescent hyperandrogenism.
Witchel SF, Smith R, Tomboc M, Aston CE
Fertil Steril. 2001
PubMed ID: 11287026
Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.
Miki H, Yamauchi T, Suzuki R, Komeda K, Tsuchida A, Kubota N, Terauchi Y, Kamon J, Kaburagi Y, Matsui J, Akanuma Y, Nagai R, Kimura S, Tobe K, Kadowaki T
Mol Cell Biol. 2001
PubMed ID: 11259600
The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.
Baroni MG, Arca M, Sentinelli F, Buzzetti R, Capici F, Lovari S, Vitale M, Romeo S, Di Mario U
Diabetologia. 2001
PubMed ID: 11317670
Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations.
Inukai K, Funaki M, Anai M, Ogihara T, Katagiri H, Fukushima Y, Sakoda H, Onishi Y, Ono H, Fujishiro M, Abe M, Oka Y, Kikuchi M, Asano T
FEBS Lett. 2001
PubMed ID: 11172806
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.
Ravichandran LV, Esposito DL, Chen J, Quon MJ
J Biol Chem. 2001
PubMed ID: 11063744
Frap-dependent serine phosphorylation of IRS-1 inhibits IRS-1 tyrosine phosphorylation.
Hartman ME, Villela-Bach M, Chen J, Freund GG
Biochem Biophys Res Commun. 2001
PubMed ID: 11162588
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.
Kawazoe Y, Naka T, Fujimoto M, Kohzaki H, Morita Y, Narazaki M, Okumura K, Saitoh H, Nakagawa R, Uchiyama Y, Akira S, Kishimoto T
J Exp Med. 2001
PubMed ID: 11208867
IRS-1 and IRS-2 are recruited by TrkA receptor and oncogenic TRK-T1.
Miranda C, Greco A, Miele C, Pierotti MA, Van Obberghen E
J Cell Physiol. 2001
PubMed ID: 11147812
Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.
Kessler A, Uphues I, Ouwens DM, Till M, Eckel J
Am J Physiol Endocrinol Metab. 2001
PubMed ID: 11120660
Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein.
Farhang-Fallah J, Yin X, Trentin G, Cheng AM, Rozakis-Adcock M
J Biol Chem. 2000
PubMed ID: 11018022
The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase.
Iwanishi M, Czech MP, Cherniack AD
J Biol Chem. 2000
PubMed ID: 11006284
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin.
Playford MP, Bicknell D, Bodmer WF, Macaulay VM
Proc Natl Acad Sci U S A. 2000
PubMed ID: 11035789
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Characterization of Drosophila insulin receptor substrate.
Poltilove RM, Jacobs AR, Haft CR, Xu P, Taylor SI
J Biol Chem. 2000
PubMed ID: 10801879
IL-4/IL-13 signaling beyond JAK/STAT.
Jiang H, Harris MB, Rothman P
J Allergy Clin Immunol. 2000
PubMed ID: 10856136
The Gly-->Arg972 amino acid polymorphism in insulin receptor substrate-1 affects glucose metabolism in skeletal muscle cells.
Hribal ML, Federici M, Porzio O, Lauro D, Borboni P, Accili D, Lauro R, Sesti G
J Clin Endocrinol Metab. 2000
PubMed ID: 10843189
Restored insulin-sensitivity in IRS-1-deficient mice treated by adenovirus-mediated gene therapy.
Ueki K, Yamauchi T, Tamemoto H, Tobe K, Yamamoto-Honda R, Kaburagi Y, Akanuma Y, Yazaki Y, Aizawa S, Nagai R, Kadowaki T
J Clin Invest. 2000
PubMed ID: 10811851
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover.
Ogata N, Chikazu D, Kubota N, Terauchi Y, Tobe K, Azuma Y, Ohta T, Kadowaki T, Nakamura K, Kawaguchi H
J Clin Invest. 2000
PubMed ID: 10749573
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307).
Aguirre V, Uchida T, Yenush L, Davis R, White MF
J Biol Chem. 2000
PubMed ID: 10722755
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.
Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M
J Biol Chem. 2000
PubMed ID: 10660596
Association of insulin receptor substrate proteins with Bcl-2 and their effects on its phosphorylation and antiapoptotic function.
Ueno H, Kondo E, Yamamoto-Honda R, Tobe K, Nakamoto T, Sasaki K, Mitani K, Furusaka A, Tanaka T, Tsujimoto Y, Kadowaki T, Hirai H
Mol Biol Cell. 2000
PubMed ID: 10679027
The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus.
Zeng W, Peng J, Wan X, Chen S, Song H
Chin Med J (Engl). 2000
PubMed ID: 11775217
A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.
Baroni MG, D'Andrea MP, Montali A, Pannitteri G, Barillà F, Campagna F, Mazzei E, Lovari S, Seccareccia F, Campa PP, Ricci G, Pozzilli P, Urbinati G, Arca M
Arterioscler Thromb Vasc Biol. 1999
PubMed ID: 10591678
Postnatal growth responses to insulin-like growth factor I in insulin receptor substrate-1-deficient mice.
Pete G, Fuller CR, Oldham JM, Smith DR, D'Ercole AJ, Kahn CR, Lund PK
Endocrinology. 1999
PubMed ID: 10579310
Calorie restriction increases insulin-stimulated glucose transport in skeletal muscle from IRS-1 knockout mice.
Gazdag AC, Dumke CL, Kahn CR, Cartee GD
Diabetes. 1999
PubMed ID: 10512356
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.
Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y
J Biol Chem. 1999
PubMed ID: 10497255
Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.
Kapeller R, Moriarty A, Strauss A, Stubdal H, Theriault K, Siebert E, Chickering T, Morgenstern JP, Tartaglia LA, Lillie J
J Biol Chem. 1999
PubMed ID: 10455176
Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation.
Xia X, Serrero G
Biochem J. 1999
PubMed ID: 10417350
Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10411883
Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.
Accili D, Nakae J, Kim JJ, Park BC, Rother KI
J Pediatr Endocrinol Metab. 1999
PubMed ID: 10417963
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility.
Mañes S, Mira E, Gómez-Mouton C, Zhao ZJ, Lacalle RA, Martínez-A C
Mol Cell Biol. 1999
PubMed ID: 10082579
C-terminal Src kinase associates with ligand-stimulated insulin-like growth factor-I receptor.
Arbet-Engels C, Tartare-Deckert S, Eckhart W
J Biol Chem. 1999
PubMed ID: 10026153
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity.
Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE, McKeon C, Darlington GJ, Spiegelman BM
Mol Cell. 1999
PubMed ID: 10078198
The plasminogen activator inhibitor-2 gene is not required for normal murine development or survival.
Dougherty KM, Pearson JM, Yang AY, Westrick RJ, Baker MS, Ginsburg D
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9892694
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).
Zhu T, Goh EL, LeRoith D, Lobie PE
J Biol Chem. 1998
PubMed ID: 9837978
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Tu Y, Li F, Wu C
Mol Biol Cell. 1998
PubMed ID: 9843575
Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src).
Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V
J Biol Chem. 1998
PubMed ID: 9822703
Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes.
VanRenterghem B, Morin M, Czech MP, Heller-Harrison RA
J Biol Chem. 1998
PubMed ID: 9792713
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.
Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR
Mol Cell. 1998
PubMed ID: 9844629
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling.
Myers MG, Mendez R, Shi P, Pierce JH, Rhoads R, White MF
J Biol Chem. 1998
PubMed ID: 9756938
Identification of the rat adapter Grb14 as an inhibitor of insulin actions.
Kasus-Jacobi A, Perdereau D, Auzan C, Clauser E, Van Obberghen E, Mauvais-Jarvis F, Girard J, Burnol AF
J Biol Chem. 1998
PubMed ID: 9748281
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.
Yamauchi T, Kaburagi Y, Ueki K, Tsuji Y, Stark GR, Kerr IM, Tsushima T, Akanuma Y, Komuro I, Tobe K, Yazaki Y, Kadowaki T
J Biol Chem. 1998
PubMed ID: 9624169
Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse.
Richards RG, Walker MP, Sebastian J, DiAugustine RP
J Biol Chem. 1998
PubMed ID: 9565625
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, Shionoiri F, Yahagi N, Kadowaki T, Tamemoto H, Ishibashi S, Yazaki Y, Makuuchi M
J Clin Invest. 1998
PubMed ID: 9541510
Insulin receptor substrate-1 is expressed at high levels in all cells of the peri-implantation mouse embryo.
Puscheck EE, Pergament E, Patel Y, Dreschler J, Rappolee DA
Mol Reprod Dev. 1998
PubMed ID: 9508089
Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor.
Gual P, Baron V, Lequoy V, Van Obberghen E
Endocrinology. 1998
PubMed ID: 9492017
14-3-3beta protein associates with insulin receptor substrate 1 and decreases insulin-stimulated phosphatidylinositol 3'-kinase activity in 3T3L1 adipocytes.
Kosaki A, Yamada K, Suga J, Otaka A, Kuzuya H
J Biol Chem. 1998
PubMed ID: 9422753
Novel allele of the insulin receptor substrate-1 bearing two non-conservative amino acid substitutions in a patient with noninsulin-dependent diabetes mellitus. Mutations in brief no. 130. Online.
Mammarella S, Creati B, Esposito DL, Arcuri P, Della Loggia F, Capani F, Mariani-Costantini R, Caramia FG, Battista P, Cama A
Hum Mutat. 1998
PubMed ID: 10206679
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.
Kerouz NJ, Hörsch D, Pons S, Kahn CR
J Clin Invest. 1997
PubMed ID: 9399964
Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins.
Mothe I, Delahaye L, Filloux C, Pons S, White MF, Van Obberghen E
Mol Endocrinol. 1997
PubMed ID: 9415396
Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene.
Sciacchitano S, Taylor SI
Endocrinology. 1997
PubMed ID: 9348224
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T
J Biol Chem. 1997
PubMed ID: 9312143
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart.
Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR
J Biol Chem. 1997
PubMed ID: 9295312
Evidence for a direct interaction between insulin receptor substrate-1 and Shc.
Kasus-Jacobi A, Perdereau D, Tartare-Deckert S, Van Obberghen E, Girard J, Burnol AF
J Biol Chem. 1997
PubMed ID: 9202037
The genetics of obesity.
Naggert J, Harris T, North M
Curr Opin Genet Dev. 1997
PubMed ID: 9229117
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
Morris SW, Naeve C, Mathew P, James PL, Kirstein MN, Cui X, Witte DP
Oncogene. 1997
PubMed ID: 9174053
14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner.
Craparo A, Freund R, Gustafson TA
J Biol Chem. 1997
PubMed ID: 9111084
Cell-specific regulation of IRS-1 gene expression: role of E box and C/EBP binding site in HepG2 cells and CHO cells.
Matsuda K, Araki E, Yoshimura R, Tsuruzoe K, Furukawa N, Kaneko K, Motoshima H, Yoshizato K, Kishikawa H, Shichiri M
Diabetes. 1997
PubMed ID: 9032089
Cloning of the chicken insulin receptor substrate 1 gene.
Taouis M, Taylor SI, Reitman M
Gene. 1996
PubMed ID: 8921891
Estradiol stimulates tyrosine phosphorylation of the insulin-like growth factor-1 receptor and insulin receptor substrate-1 in the uterus.
Richards RG, DiAugustine RP, Petrusz P, Clark GC, Sebastian J
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8876252
Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
Okada S, Pessin JE
J Biol Chem. 1996
PubMed ID: 8810325
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10.
Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW
Mol Endocrinol. 1996
PubMed ID: 8776723
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.
Yamauchi T, Tobe K, Tamemoto H, Ueki K, Kaburagi Y, Yamamoto-Honda R, Takahashi Y, Yoshizawa F, Aizawa S, Akanuma Y, Sonenberg N, Yazaki Y, Kadowaki T
Mol Cell Biol. 1996
PubMed ID: 8649419
Interaction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2.
He W, Craparo A, Zhu Y, O'Neill TJ, Wang LM, Pierce JH, Gustafson TA
J Biol Chem. 1996
PubMed ID: 8662806
Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action.
Mothe I, Van Obberghen E
J Biol Chem. 1996
PubMed ID: 8626671
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation.
Sun XJ, Pons S, Asano T, Myers MG, Glasheen E, White MF
J Biol Chem. 1996
PubMed ID: 8631859
Modulation of insulin signal transduction by eutopic overexpression of the receptor-type protein-tyrosine phosphatase LAR.
Zhang WR, Li PM, Oswald MA, Goldstein BJ
Mol Endocrinol. 1996
PubMed ID: 8732688
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, Yamamoto T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8633037
The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling.
Beitner-Johnson D, Blakesley VA, Shen-Orr Z, Jimenez M, Stannard B, Wang LM, Pierce J, LeRoith D
J Biol Chem. 1996
PubMed ID: 8621590
Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus.
Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H
J Biol Chem. 1996
PubMed ID: 8621530
Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trüb T, Shoelson SE, Fesik SW
Nat Struct Biol. 1996
PubMed ID: 8599766
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786.
Sawka-Verhelle D, Tartare-Deckert S, White MF, Van Obberghen E
J Biol Chem. 1996
PubMed ID: 8626379
Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo.
Isakoff SJ, Yu YP, Su YC, Blaikie P, Yajnik V, Rose E, Weidner KM, Sachs M, Margolis B, Skolnik EY
J Biol Chem. 1996
PubMed ID: 8626723
The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling.
Kulas DT, Freund GG, Mooney RA
J Biol Chem. 1996
PubMed ID: 8557683
The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2.
Platanias LC, Uddin S, Yetter A, Sun XJ, White MF
J Biol Chem. 1996
PubMed ID: 8550573
Deletion of Gly723 in the insulin receptor substrate-1 of a patient with noninsulin-dependent diabetes mellitus.
Esposito DL, Mammarella S, Ranieri A, Della Loggia F, Capani F, Consoli A, Mariani-Costantini R, Caramia FG, Cama A, Battista P
Hum Mutat. 1996
PubMed ID: 8723689
Substrate specificities of the insulin and insulin-like growth factor 1 receptor tyrosine kinase catalytic domains.
Xu B, Bird VG, Miller WT
J Biol Chem. 1995
PubMed ID: 8530377
Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW
Nature. 1995
PubMed ID: 8524391
Involvement of Janus kinases in the insulin signaling pathway.
Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E
Eur J Biochem. 1995
PubMed ID: 8536716
Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases.
Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ
J Biol Chem. 1995
PubMed ID: 7499365
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities.
Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE
J Biol Chem. 1995
PubMed ID: 7499194
Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells.
Wang L, Hayashi H, Mitani Y, Ishii K, Ohnishi T, Niwa Y, Kido H, Ebina Y
Biochem Biophys Res Commun. 1995
PubMed ID: 7488107
Ornithine decarboxylase induction during liver regeneration in IRS-1-deficient mice.
Furusaka A, Nishiyama M, Nishimaki H, Ogasawara Y, Tamemoto H, Yamauchi T, Tobe K, Kadowaki T, Tanaka T
Biochem Biophys Res Commun. 1995
PubMed ID: 7488102
Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid system.
Tartare-Deckert S, Sawka-Verhelle D, Murdaca J, Van Obberghen E
J Biol Chem. 1995
PubMed ID: 7559507
Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.
He W, O'Neill TJ, Gustafson TA
J Biol Chem. 1995
PubMed ID: 7559478
Characterization and regulation of the mouse insulin receptor substrate gene promoter.
Araki E, Haag BL, Matsuda K, Shichiri M, Kahn CR
Mol Endocrinol. 1995
PubMed ID: 8544845
Role of IRS-2 in insulin and cytokine signalling.
Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG, Glasheen E, Lane WS, Pierce JH, White MF
Nature. 1995
PubMed ID: 7675087
Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases.
Yin T, Keller SR, Quelle FW, Witthuhn BA, Tsang ML, Lienhard GE, Ihle JN, Yang YC
J Biol Chem. 1995
PubMed ID: 7544789
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.
Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG, Sun XJ, White MF
Mol Cell Biol. 1995
PubMed ID: 7542745
Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region.
Voliovitch H, Schindler DG, Hadari YR, Taylor SI, Accili D, Zick Y
J Biol Chem. 1995
PubMed ID: 7629118
Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor.
Craparo A, O'Neill TJ, Gustafson TA
J Biol Chem. 1995
PubMed ID: 7541045
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.
Argetsinger LS, Hsu GW, Myers MG, Billestrup N, White MF, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7782332
Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
Gustafson TA, He W, Craparo A, Schaub CD, O'Neill TJ
Mol Cell Biol. 1995
PubMed ID: 7537849
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1.
Tobe K, Tamemoto H, Yamauchi T, Aizawa S, Yazaki Y, Kadowaki T
J Biol Chem. 1995
PubMed ID: 7534300
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.
Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S
Nature. 1994
PubMed ID: 7969452
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.
Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR
Nature. 1994
PubMed ID: 7526222
Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
Noguchi T, Matozaki T, Horita K, Fujioka Y, Kasuga M
Mol Cell Biol. 1994
PubMed ID: 7935386
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system.
O'Neill TJ, Craparo A, Gustafson TA
Mol Cell Biol. 1994
PubMed ID: 7935368
The IRS-1 signaling system.
Myers MG, Sun XJ, White MF
Trends Biochem Sci. 1994
PubMed ID: 8048169
Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1.
Araki E, Haag BL, Kahn CR
Biochim Biophys Acta. 1994
PubMed ID: 8167159
The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36.
Nishiyama M, Inazawa J, Ariyama T, Nakamura Y, Matsufuji S, Furusaka A, Tanaka T, Hayashi S, Wands JR
Genomics. 1994
PubMed ID: 8020946
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1.
Sun XJ, Crimmins DL, Myers MG, Miralpeix M, White MF
Mol Cell Biol. 1993
PubMed ID: 7504175
The insulin receptor substrate (IRS-1) is a PEST protein that is susceptible to calpain degradation in vitro.
Smith LK, Bradshaw M, Croall DE, Garner CW
Biochem Biophys Res Commun. 1993
PubMed ID: 8240352
Phosphorylation of the insulin receptor substrate IRS-1 by casein kinase II.
Tanasijevic MJ, Myers MG, Thoma RS, Crimmins DL, White MF, Sacks DB
J Biol Chem. 1993
PubMed ID: 8349691
Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization.
Araki E, Sun XJ, Haag BL, Chuang LM, Zhang Y, Yang-Feng TL, White MF, Kahn CR
Diabetes. 1993
PubMed ID: 8513971
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J
Science. 1993
PubMed ID: 8316835
The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp.
Kuhné MR, Pawson T, Lienhard GE, Feng GS
J Biol Chem. 1993
PubMed ID: 8505282
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
Tobe K, Matuoka K, Tamemoto H, Ueki K, Kaburagi Y, Asai S, Noguchi T, Matsuda M, Tanaka S, Hattori S
J Biol Chem. 1993
PubMed ID: 8388384
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF
EMBO J. 1993
PubMed ID: 8491186
The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning.
Keller SR, Aebersold R, Garner CW, Lienhard GE
Biochim Biophys Acta. 1993
PubMed ID: 8448209
Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.
Hadari YR, Tzahar E, Nadiv O, Rothenberg P, Roberts CT, LeRoith D, Yarden Y, Zick Y
J Biol Chem. 1992
PubMed ID: 1381348
Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.
Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J
EMBO J. 1992
PubMed ID: 1380456
The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains.
Lavan BE, Kuhné MR, Garner CW, Anderson D, Reedijk M, Pawson T, Lienhard GE
J Biol Chem. 1992
PubMed ID: 1375946
Cloning and increased expression of an insulin receptor substrate-1-like gene in human hepatocellular carcinoma.
Nishiyama M, Wands JR
Biochem Biophys Res Commun. 1992
PubMed ID: 1311924
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein.
Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF
Nature. 1991
PubMed ID: 1648180
Purification and partial sequence analysis of pp185, the major cellular substrate of the insulin receptor tyrosine kinase.
Rothenberg PL, Lane WS, Karasik A, Backer J, White M, Kahn CR
J Biol Chem. 1991
PubMed ID: 2022647
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3667	16367	25467
EnsEMBL Gene(s)	ENSG00000169047	ENSMUSG00000055980	ENSRNOG00000014597
Unigene	Hs.471508	Mm.4952	Rn.10476
Homologene	IRS1	Irs1	Irs1
OMIM	147545	N/A	N/A
GeneCards	IRS1	N/A	N/A
Beta Cell Genomics	DT.112047	DT.101736484 DT.91288547 DT.91442113	N/A
Reactome	P35568	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	3667	16367	25467

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
IRS1	SCML2	IntAct	empirical	15602769
IRS1	IPO8	IntAct	empirical	15602769
IRS1	KHDRBS1	BioGRID	empirical	11604231
IRS1	NISCH	BioGRID	empirical	11912194
IRS1	CHUK	HPRD, BioGRID	empirical	12351658
IRS1	AP3S1	HPRD, BioGRID	empirical	9792713
IRS1	CRK	HPRD, MINT, Reactome	empirical	8810325 9837978 8621590 10660596
IRS1	CSNK2A1	HPRD	empirical	8349691
IRS1	CSNK2B	HPRD	empirical	8349691
IRS1	CTNNB1	IntAct	empirical	15602769
IRS1	CTNND1	IntAct	empirical	15602769
IRS1	EGFR	MINT	empirical	16273093
IRS1	EPHA2	IntAct	empirical	15602769
IRS1	ERBB2	MINT	empirical	16273093
IRS1	AKT1	HPRD, BioGRID	empirical	10497255
IRS1	ESR1	BioGRID	empirical	12821935
IRS1	FER	HPRD	empirical	11006284
IRS1	FES	HPRD	empirical	10856136
IRS1	FLOT2	IntAct	empirical	15602769
IRS1	SIK2	HPRD	empirical	12624099
IRS1	SIRT1	IntAct	empirical	21241768 17901049
IRS1	ALK	HPRD, BioGRID	empirical	9174053 14968112
IRS1	MTOR	HPRD, BioGRID	empirical	11287630
IRS1	FYN	HPRD	empirical	8631859
IRS1	GHR	HPRD	empirical	7782332
IRS1	SND1	IntAct	empirical	15602769
IRS1	SFN	MINT, BioGRID	empirical	15778465
IRS1	GRB2	HPRD, MINT, IntAct, BioGRID, Reactome	empirical	7488107 8810325 8388384 10660596 12446583 12679424 21706016 8491186 12173038 8536716
IRS1	GRB14	HPRD, MINT	empirical	9748281 15924411
IRS1	GRIN1	IntAct	empirical	16635246
IRS1	GRIN2B	IntAct	empirical	16635246
IRS1	H1F0	IntAct	empirical	15602769
IRS1	HDAC2	BioGRID	empirical	15522123
IRS1	HNRNPU	IntAct	empirical	15602769
IRS1	HSPA8	IntAct	empirical	15602769
IRS1	HSP90AB1	IntAct	empirical	15602769
IRS1	IGF1R	HPRD, IntAct, BioGRID	empirical	7559507 8662806 15629149 12220227 8530377 7541045 8776723 10082579
IRS1	IKBKB	HPRD, BioGRID	empirical	12351658 11606564 10722755
IRS1	IL4R	HPRD	empirical	8599766
IRS1	INSR	HPRD, MINT, IntAct, MIPS, BioGRID	empirical	11606564 8662806 15629149 16582879 7935368 12446583 10660596 11136729 17135270 15924411 10218944 8626379
IRS1	IRS1	HPRD	empirical	10411883
IRS1	ITGB2	MINT	empirical	12606711
IRS1	ITGB3	MINT	empirical	12606711
IRS1	JAK1	HPRD, BioGRID	empirical	11162588 9492017 7499365
IRS1	JAK2	HPRD, MIPS, BioGRID	empirical	12960006 10218944 9492017 11208867
IRS1	JAK3	HPRD, BioGRID	empirical	7499365
IRS1	AFF3	IntAct	empirical	15602769
IRS1	SMAD3	IntAct	empirical	18729074
IRS1	NPM1	HPRD, MIPS	empirical	8633037
IRS1	ATP2A1	HPRD	empirical	9295312
IRS1	ATP2A2	HPRD	empirical	9295312
IRS1	ATP2A3	HPRD	empirical	12524443
IRS1	YBX1	IntAct	empirical	15602769
IRS1	NTRK1	HPRD, Reactome	empirical	11147812
IRS1	RAB6B	IntAct	empirical	15602769
IRS1	PDPK1	HPRD	empirical	15802620
IRS1	PHB	IntAct	empirical	15602769
IRS1	PIK3CA	MINT, BioGRID	empirical	16150444 16354680
IRS1	PIK3R1	HPRD, MINT, IntAct, BioGRID	empirical	12220227 12173038 1381348 16230374 16043515 16150444 18059474 10660596 16919274 11136729 12446583 12679424 12730242 15380067 12594288 12107746
IRS1	PIK3R2	HPRD, BioGRID	empirical	11120660 7559478 12730242
IRS1	PHIP	HPRD, IntAct	empirical	11018022
IRS1	PPP2R1A	IntAct	empirical	15602769
IRS1	IPO9	IntAct	empirical	15602769
IRS1	ODZ3	IntAct	empirical	15602769
IRS1	PRKCD	HPRD, BioGRID	empirical	12031982 15364919 15516986
IRS1	PRKCG	HPRD	empirical	15364919
IRS1	CAND1	IntAct	empirical	15602769
IRS1	PRKCQ	HPRD	empirical	15364919
IRS1	PRKCZ	HPRD, MINT	empirical	11063744
IRS1	MAPK1	HPRD	empirical	16131083
IRS1	MAPK8	HPRD, BioGRID	empirical	12417588 11606564 10722755 12351658
IRS1	MAPK9	HPRD	empirical	12417588
IRS1	EIF2AK2	IntAct	empirical	20144759
IRS1	PTK2	HPRD, BioGRID	empirical	9822703
IRS1	RPTOR	HPRD	empirical	16354680
IRS1	PTPN1	HPRD, MINT, BioGRID	empirical	10660596 11579209 10751417
IRS1	PTPN11	HPRD, MINT, BioGRID	empirical	8505282 9756938 7935386 10660596
IRS1	PTPRA	MINT	empirical	10660596
IRS1	PTPRC	HPRD	empirical	8557683
IRS1	PTPRF	HPRD, MINT	empirical	10660596 8732688 15588985
IRS1	RAD51	HPRD	empirical	14559999
IRS1	RAN	IntAct	empirical	15602769
IRS1	RARS	IntAct	empirical	15602769
IRS1	BCL2	BioGRID	empirical	10679027
IRS1	BCL2L1	HPRD, BioGRID	empirical	10679027
IRS1	RFC3	IntAct	empirical	15602769
IRS1	ROCK1	HPRD	empirical	11739394
IRS1	BCR	HPRD	empirical	12560071
IRS1	RPLP0	IntAct	empirical	15602769
IRS1	RPN2	IntAct	empirical	15602769
IRS1	RPS3	IntAct	empirical	15602769
IRS1	SHC1	HPRD, BioGRID	empirical	7499194
IRS1	TP53BP2	IntAct	empirical	17965023
IRS1	TUB	HPRD	empirical	10455176
IRS1	TYK2	HPRD	empirical	8550573
IRS1	UBC	BioGRID	empirical	15516986 12821935 19546233 20663861 21139048
IRS1	UBTF	HPRD, BioGRID	empirical	12554758 17332342
IRS1	UNG	IntAct	empirical	15602769
IRS1	VIM	IntAct	empirical	15602769
IRS1	YWHAB	HPRD, IntAct, BioGRID	empirical	9422753 17965023
IRS1	YWHAE	HPRD, MINT, IntAct, BioGRID	empirical	9312143 9111084 17965023 16944949
IRS1	YWHAG	HPRD, IntAct	empirical	15324660 15602769
IRS1	YWHAH	BioGRID	empirical	11969417
IRS1	YWHAZ	HPRD	empirical	9312143
IRS1	DDR1	IntAct	empirical	17721511
IRS1	POLDIP3	IntAct	empirical	15602769
IRS1	SDPR	IntAct	empirical	15602769
IRS1	NCK2	BioGRID	empirical	9843575
IRS1	PPFIBP1	IntAct	empirical	15602769
IRS1	PIK3R3	HPRD, MIPS, BioGRID	empirical	7542745 10417350 9415396
IRS1	CAV1	HPRD	empirical	15003536
IRS1	SOCS1	HPRD, BioGRID	empirical	12228220 11208867
IRS1	IRS2	BioGRID	empirical	12554758
IRS1	CBL	BioGRID	empirical	19546233
IRS1	CBLB	BioGRID	empirical	16734387
IRS1	SOCS3	HPRD	empirical	12228220
IRS1	RQCD1	IntAct	empirical	15602769
IRS1	CDH1	HPRD	empirical	11035789