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INS

Gene Description:   insulin II; insulin 2; insulin Synonyms:   ILPR, AA986540, MODY10, IRDN, IDDM2, Ins2, Mody, Ins-2, InsII, INS, Mody4, proinsulin Orthologs:   Human INS (protein-coding), Mouse Ins2 (protein-coding), Rat Ins2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD Human-Rat: HomoloGene, MGD, RGD Mouse-Rat: HomoloGene, MGD, RGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 3

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
11p15.5	Human	chr11:2068424..2308304	0.24	37	rs689 rs7111341

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	560

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 11p15.5 Orthologous Region	Mouse	chr7:149800921..150160408	0.36	6
Human 11p15.5 Orthologous Region	Rat	chr1:202870115..203251634	0.38	4
Iddm25	Rat	chr1:193831373..230411453	36.58	766

(Human) GRCh37 - chr11:2181009..2182571 (1.56 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr7:149864561..149885415 (20.85 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr1:202935548..202936379 (831 bp)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for INS: The INS interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs INS   CPE   HPRD  empirical  10966857  7477119  INS   CTSB   HPRD  empirical  6351842  INS   CTSD   HPRD  empirical  11779865  INS   CTSE   HPRD  empirical  1959628  195962  INS   GCK   HPRD  empirical  12101177  INS   HLA-DQA2   HPRD  empirical  11376336  INS   HLA-DQB1   HPRD  empirical  11376336  INS   IDE   HPRD  empirical  11145591  17051221  INS   IGF1R   HPRD  empirical  1851182  INS   IGFBP7   HPRD  empirical  9388210  INS   INS   HPRD, MINT, Reactome  empirical  12021212  10508408  8844841  INS   INSR   HPRD  empirical  2550426  INS   LRP2   HPRD  empirical  9773776  INS   NOV   HPRD  empirical  10084601  INS   RB1   HPRD  empirical  10938588  7818556  INS   TXNDC17   HPRD  empirical  14607844  INS   SYTL4   HPRD  empirical  10497219

View all

KEGG Network: 11   Aldosterone-regulated sodium reabsorption Human - 4960 Mouse - 4960 Rat - 4960 Insulin signaling pathway Human - 4910 Mouse - 4910 Rat - 4910 Maturity onset diabetes of the young Human - 4950 Mouse - 4950 Rat - 4950 mTOR signaling pathway Human - 4150 Mouse - 4150 Rat - 4150 Oocyte meiosis Human - 4114 Mouse - 4114 Rat - 4114 Progesterone-mediated oocyte maturation Human - 4914 Mouse - 4914 Rat - 4914 Prostate cancer Human - 5215 Mouse - 5215 Rat - 5215 Regulation of actin cytoskeleton Human - 4810 Mouse - 4810 Rat - 4810 Regulation of autophagy Human - 4140 Mouse - 4140 Rat - 4140 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940 Type II diabetes mellitus Human - 4930 Mouse - 4930 Rat - 4930

Biocarta: 3   Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) Mouse Growth Hormone Signaling Pathway Mouse Insulin Signaling Pathway Mouse

Reactome: 19   Diabetes pathways REACT_15380 Downstream signaling of activated FGFR REACT_21272 Insulin receptor recycling REACT_1109 Insulin receptor signalling cascade REACT_1195 Insulin Synthesis and Processing REACT_15550 Integration of energy metabolism REACT_1505 IRS activation REACT_570 IRS-mediated signalling REACT_332 IRS-related events REACT_762 PI-3K cascade REACT_21270 PI3K Cascade REACT_976 Regulation of beta-cell development REACT_13698 Regulation of gene expression in beta cells REACT_13819 Regulation of Insulin Secretion REACT_18325 SHC activation REACT_1661 SHC-related events REACT_999 Signal attenuation REACT_508 Signaling by FGFR REACT_9470 Signaling by Insulin receptor REACT_498

NCI-Nature Pathway Interaction Database: 8   Signaling events mediated by PTP1B Arf6 trafficking events Signaling events mediated by TCPTP ATF-2 transcription factor network Insulin-mediated glucose transport FOXA2 and FOXA3 transcription factor networks FOXA1 transcription factor network Insulin Pathway

Gene Ontology: 68   MAPKKK cascade GO:0000165 Negative regulation of acute inflammatory response GO:0002674 Insulin receptor binding GO:0005158 Insulin-like growth factor receptor binding GO:0005159 Hormone activity GO:0005179 Protein binding GO:0005515 Extracellular region GO:0005576 Extracellular space GO:0005615 Endoplasmic reticulum lumen GO:0005788 Golgi lumen GO:0005796 Carbohydrate metabolic process GO:0005975 Glucose metabolic process GO:0006006 Energy reserve metabolic process GO:0006112 Regulation of transcription, DNA-dependent GO:0006355 Regulation of cellular amino acid metabolic process GO:0006521 Acute-phase response GO:0006953 G-protein coupled receptor protein signaling pathway GO:0007186 Cell-cell signaling GO:0007267 Positive regulation of cell proliferation GO:0008284 Insulin receptor signaling pathway GO:0008286 Fibroblast growth factor receptor signaling pathway GO:0008543 Positive regulation of phosphatidylinositol 3-kinase cascade GO:0014068 Glucose transport GO:0015758 Regulation of transmembrane transporter activity GO:0022898 Stored secretory granule GO:0030141 Positive regulation of cell growth GO:0030307 Positive regulation of cell migration GO:0030335 Endocrine pancreas development GO:0031018 Endosome lumen GO:0031904 Positive regulation of protein autophosphorylation GO:0031954 Activation of protein kinase B activity GO:0032148 Positive regulation of cellular protein metabolic process GO:0032270 Regulation of protein localization GO:0032880 Negative regulation of NAD(P)H oxidase activity GO:0033861 Wound healing GO:0042060 Negative regulation of protein catabolic process GO:0042177 Glucose homeostasis GO:0042593 Negative regulation of apoptosis GO:0043066 Positive regulation of MAPKKK cascade GO:0043410 Positive regulation of nitric oxide biosynthetic process GO:0045429 Positive regulation of cell differentiation GO:0045597 Negative regulation of gluconeogenesis GO:0045721 Positive regulation of glycogen biosynthetic process GO:0045725 Positive regulation of DNA replication GO:0045740 Negative regulation of glycogen catabolic process GO:0045818 Positive regulation of glycolysis GO:0045821 Positive regulation of mitosis GO:0045840 Negative regulation of proteolysis GO:0045861 Negative regulation of vasodilation GO:0045908 Positive regulation of vasodilation GO:0045909 Negative regulation of fatty acid metabolic process GO:0045922 Positive regulation of glucose import GO:0046326 Positive regulation of insulin receptor signaling pathway GO:0046628 Alpha-beta T cell activation GO:0046631 Positive regulation of lipid biosynthetic process GO:0046889 Regulation of protein secretion GO:0050708 Negative regulation of protein secretion GO:0050709 Positive regulation of cytokine secretion GO:0050715 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Regulation of insulin secretion GO:0050796 Negative regulation of lipid catabolic process GO:0050995 Positive regulation of nitric-oxide synthase activity GO:0051000 Positive regulation of NF-kappaB transcription factor activity GO:0051092 Positive regulation of protein kinase B signaling cascade GO:0051897 Fatty acid homeostasis GO:0055089 Negative regulation of respiratory burst involved in inflammatory response GO:0060266 Positive regulation of respiratory burst GO:0060267 Negative regulation of feeding behavior GO:2000252

	KEGG Network: 11 Aldosterone-regulated sodium reabsorption Human - 4960 Mouse - 4960 Rat - 4960 Insulin signaling pathway Human - 4910 Mouse - 4910 Rat - 4910 Maturity onset diabetes of the young Human - 4950 Mouse - 4950 Rat - 4950 mTOR signaling pathway Human - 4150 Mouse - 4150 Rat - 4150 Oocyte meiosis Human - 4114 Mouse - 4114 Rat - 4114 Progesterone-mediated oocyte maturation Human - 4914 Mouse - 4914 Rat - 4914 Prostate cancer Human - 5215 Mouse - 5215 Rat - 5215 Regulation of actin cytoskeleton Human - 4810 Mouse - 4810 Rat - 4810 Regulation of autophagy Human - 4140 Mouse - 4140 Rat - 4140 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940 Type II diabetes mellitus Human - 4930 Mouse - 4930 Rat - 4930
	Biocarta: 3 Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) Mouse Growth Hormone Signaling Pathway Mouse Insulin Signaling Pathway Mouse
	Reactome: 19 Diabetes pathways REACT_15380 Downstream signaling of activated FGFR REACT_21272 Insulin receptor recycling REACT_1109 Insulin receptor signalling cascade REACT_1195 Insulin Synthesis and Processing REACT_15550 Integration of energy metabolism REACT_1505 IRS activation REACT_570 IRS-mediated signalling REACT_332 IRS-related events REACT_762 PI-3K cascade REACT_21270 PI3K Cascade REACT_976 Regulation of beta-cell development REACT_13698 Regulation of gene expression in beta cells REACT_13819 Regulation of Insulin Secretion REACT_18325 SHC activation REACT_1661 SHC-related events REACT_999 Signal attenuation REACT_508 Signaling by FGFR REACT_9470 Signaling by Insulin receptor REACT_498
	NCI-Nature Pathway Interaction Database: 8 Signaling events mediated by PTP1B Arf6 trafficking events Signaling events mediated by TCPTP ATF-2 transcription factor network Insulin-mediated glucose transport FOXA2 and FOXA3 transcription factor networks FOXA1 transcription factor network Insulin Pathway
	Gene Ontology: 68 MAPKKK cascade GO:0000165 Negative regulation of acute inflammatory response GO:0002674 Insulin receptor binding GO:0005158 Insulin-like growth factor receptor binding GO:0005159 Hormone activity GO:0005179 Protein binding GO:0005515 Extracellular region GO:0005576 Extracellular space GO:0005615 Endoplasmic reticulum lumen GO:0005788 Golgi lumen GO:0005796 Carbohydrate metabolic process GO:0005975 Glucose metabolic process GO:0006006 Energy reserve metabolic process GO:0006112 Regulation of transcription, DNA-dependent GO:0006355 Regulation of cellular amino acid metabolic process GO:0006521 Acute-phase response GO:0006953 G-protein coupled receptor protein signaling pathway GO:0007186 Cell-cell signaling GO:0007267 Positive regulation of cell proliferation GO:0008284 Insulin receptor signaling pathway GO:0008286 Fibroblast growth factor receptor signaling pathway GO:0008543 Positive regulation of phosphatidylinositol 3-kinase cascade GO:0014068 Glucose transport GO:0015758 Regulation of transmembrane transporter activity GO:0022898 Stored secretory granule GO:0030141 Positive regulation of cell growth GO:0030307 Positive regulation of cell migration GO:0030335 Endocrine pancreas development GO:0031018 Endosome lumen GO:0031904 Positive regulation of protein autophosphorylation GO:0031954 Activation of protein kinase B activity GO:0032148 Positive regulation of cellular protein metabolic process GO:0032270 Regulation of protein localization GO:0032880 Negative regulation of NAD(P)H oxidase activity GO:0033861 Wound healing GO:0042060 Negative regulation of protein catabolic process GO:0042177 Glucose homeostasis GO:0042593 Negative regulation of apoptosis GO:0043066 Positive regulation of MAPKKK cascade GO:0043410 Positive regulation of nitric oxide biosynthetic process GO:0045429 Positive regulation of cell differentiation GO:0045597 Negative regulation of gluconeogenesis GO:0045721 Positive regulation of glycogen biosynthetic process GO:0045725 Positive regulation of DNA replication GO:0045740 Negative regulation of glycogen catabolic process GO:0045818 Positive regulation of glycolysis GO:0045821 Positive regulation of mitosis GO:0045840 Negative regulation of proteolysis GO:0045861 Negative regulation of vasodilation GO:0045908 Positive regulation of vasodilation GO:0045909 Negative regulation of fatty acid metabolic process GO:0045922 Positive regulation of glucose import GO:0046326 Positive regulation of insulin receptor signaling pathway GO:0046628 Alpha-beta T cell activation GO:0046631 Positive regulation of lipid biosynthetic process GO:0046889 Regulation of protein secretion GO:0050708 Negative regulation of protein secretion GO:0050709 Positive regulation of cytokine secretion GO:0050715 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Regulation of insulin secretion GO:0050796 Negative regulation of lipid catabolic process GO:0050995 Positive regulation of nitric-oxide synthase activity GO:0051000 Positive regulation of NF-kappaB transcription factor activity GO:0051092 Positive regulation of protein kinase B signaling cascade GO:0051897 Fatty acid homeostasis GO:0055089 Negative regulation of respiratory burst involved in inflammatory response GO:0060266 Positive regulation of respiratory burst GO:0060267 Negative regulation of feeding behavior GO:2000252

Type 1 Diabetes Publications: 444

• Proinsulin maturation disorder is a contributor to the defect of subsequent conversion to insulin in β-cells.
  Wang J, Osei K
  Biochem Biophys Res Commun. 2011
  PubMed ID: 21723250
   
  
• Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis; a model of type 1 diabetic macrovascular disease.
  Zhou C, Pridgen B, King N, Xu J, Breslow JL
  J Lipid Res. 2011
  PubMed ID: 21606463
   
  
• Dual and opposing roles of the unfolded protein response regulated by IRE1{alpha} and XBP1 in proinsulin processing and insulin secretion.
  Lee AH, Heidtman K, Hotamisligil GS, Glimcher LH
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21555585
   
  
• The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.
  Kim SY, Rane SG
  Development. 2011
  PubMed ID: 21490060
   
  
• Protein phosphatase 1 (PP-1)-dependent inhibition of insulin secretion by leptin in INS-1 pancreatic β-cells and human pancreatic islets.
  Kuehnen P, Laubner K, Raile K, Schöfl C, Jakob F, Pilz I, Päth G, Seufert J
  Endocrinology. 2011
  PubMed ID: 21427225
   
  
• Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development.
  Liu J, Hunter CS, Du A, Ediger B, Walp E, Murray J, Stein R, May CL
  J Biol Chem. 2011
  PubMed ID: 21388963
   
  
• Spontaneously diabetic Ins2+/Akita:ApoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis.
  Jun JY, Ma Z, Segar L
  Am J Physiol Endocrinol Metab. 2011
  PubMed ID: 21447785
   
  
• Insulin autoantibodies with high affinity to the bovine milk protein alpha casein.
  Adler K, Mueller DB, Achenbach P, Krause S, Heninger AK, Ziegler AG, Bonifacio E
  Clin Exp Immunol. 2011
  PubMed ID: 21361910
   
  
• Does the relative risk for type 1 diabetes conferred by HLA-DQ, INS, and PTPN22 polymorphisms vary with maternal age, birth weight, or cesarean section?
  Stene LC, Rønningen KS, Undlien DE, Joner G
  Pediatr Diabetes. 2011
  PubMed ID: 21352425
   
  
• Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription.
  Xu Z, Wei G, Chepelev I, Zhao K, Felsenfeld G
  Nat Struct Mol Biol. 2011
  PubMed ID: 21336277
   
  
• Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development.
  Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A
  Dev Dyn. 2011
  PubMed ID: 21287656
   
  
• Rictor/mTORC2 Is Essential for Maintaining a Balance Between {beta}-Cell Proliferation and Cell Size.
  Gu Y, Lindner J, Kumar A, Yuan W, Magnuson MA
  Diabetes. 2011
  PubMed ID: 21266327
   
  
• INS VNTR class genotype and the function of isolated human islets.
  D'Aleo V, Del Guerra S, Groves C, Lupi R, Tancredi M, McCarthy M, Marchetti P
  Nutr Metab Cardiovasc Dis. 2011
  PubMed ID: 21193298
   
  
• Prediction and prevention of Type 1 diabetes mellitus.
  Zhang L, Eisenbarth GS
  J Diabetes. 2011
  PubMed ID: 21073664
   
  
• Circulating sphingolipid biomarkers in models of type 1 diabetes.
  Fox TE, Bewley MC, Unrath KA, Pedersen MM, Anderson RE, Jung DY, Jefferson LS, Kim JK, Bronson SK, Flanagan JM, Kester M
  J Lipid Res. 2011
  PubMed ID: 21068007
   
  
• Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
  Stefan M, Simmons RA, Bertera S, Trucco MM, Esni F, Drain P, Nicholls RD
  Am J Physiol Endocrinol Metab. 2011
  PubMed ID: 21343540
   
  
• Nucleo-cytosolic shuttling of FOXO1 directly regulates mouse INS2 but not INS1 gene expression in pancreatic beta cells (min6).
  Meur G, Qian Q, da Silva Xavier G, Pullen TJ, Tsuboi T, McKinnon C, Fletcher L, Tavaré JM, Hughes S, Johnson P, Rutter GA
  J Biol Chem. 2011
  PubMed ID: 21335550
   
  
• Differential expression pattern of ZAC in developing mouse and human pancreas.
  Du X, Rousseau M, Ounissi-Benkalha H, Marchand L, Jetha A, Paraskevas S, Goodyer C, Polychronakos C
  J Mol Histol. 2011
  PubMed ID: 21305342
   
  
• Biphasic effects of insulin on islet amyloid polypeptide membrane disruption.
  Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A
  Biophys J. 2011
  PubMed ID: 21281583
   
  
• α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.
  Huang G, Ge G, Wang D, Gopalakrishnan B, Butz DH, Colman RJ, Nagy A, Greenspan DS
  J Clin Invest. 2011
  PubMed ID: 21293061
   
  
• The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas.
  Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK
  Diabetes. 2011
  PubMed ID: 21270265
   
  
• Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.
  Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M
  Development. 2011
  PubMed ID: 21266405
   
  
• Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
  Miyatsuka T, Kosaka Y, Kim H, German MS
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21173230
   
  
• A new variant of a known mutation in two siblings with permanent neonatal diabetes mellitus.
  Aycan Z, Cetinkaya S, Oğuz SS, Ceylaner S
  J Pediatr Endocrinol Metab. 2011
  PubMed ID: 21823539
   
  
• Control of Precursor Maturation and Disposal Is an Early Regulative Mechanism in the Normal Insulin Production of Pancreatic β-Cells.
  Wang J, Chen Y, Yuan Q, Tang W, Zhang X, Osei K
  PLoS One. 2011
  PubMed ID: 21559376
   
  
• Pancreatic β-cells are generated by neogenesis from non-β-cells after birth.
  Nakamura K, Minami K, Tamura K, Iemoto K, Miki T, Seino S
  Biomed Res. 2011
  PubMed ID: 21551953
   
  
• The 5'VNTR proinsulin gene (INS) polymorphism and the functional reserve of β cells in the intravenous glucose tolerance test.
  Fendler W, Wyka K, Cieślik-Heinrich A, Polakowska E, Jastrzębska J, Młynarski W
  Pediatr Endocrinol Diabetes Metab. 2011
  PubMed ID: 21507316
   
  
• HLA genes, islet autoantibodies and residual C-peptide at the clinical onset of type 1 diabetes mellitus and the risk of retinopathy 15 years later.
  Jensen RA, Agardh E, Lernmark A, Gudbjörnsdottir S, Smith NL, Siscovick DS, Törn C, DISS Group
  PLoS One. 2011
  PubMed ID: 21412422
   
  
• Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.
  Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S
  Nat Genet. 2011
  PubMed ID: 21113154
   
  
• N-terminal segment of proinsulin C-peptide active in insulin interaction/desaggregation.
  Nerelius C, Alvelius G, Jörnvall H
  Biochem Biophys Res Commun. 2010
  PubMed ID: 21094141
   
  
• Dachshund homologues play a conserved role in islet cell development.
  Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS
  Dev Biol. 2010
  PubMed ID: 20869363
   
  
• Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.
  Aminkeng F, Weets I, Van Autreve JE, Koeleman BP, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ, Belgian Diabetes Registry
  Hum Immunol. 2010
  PubMed ID: 20849903
   
  
• Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation.
  Plank JL, Mundell NA, Frist AY, Legrone AW, Kim T, Musser MA, Walter TJ, Labosky PA
  Dev Biol. 2010
  PubMed ID: 21081123
   
  
• Pparg-P465L mutation worsens hyperglycemia in Ins2-Akita female mice via adipose-specific insulin resistance and storage dysfunction.
  Pendse AA, Johnson LA, Tsai YS, Maeda N
  Diabetes. 2010
  PubMed ID: 20724579
   
  
• Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.
  Liu M, Hodish I, Haataja L, Lara-Lemus R, Rajpal G, Wright J, Arvan P
  Trends Endocrinol Metab. 2010
  PubMed ID: 20724178
   
  
• Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ.
  Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, Kalyanaraman B, Darley-Usmar V
  Biochem J. 2010
  PubMed ID: 20825366
   
  
• Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.
  Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA
  J Clin Invest. 2010
  PubMed ID: 20811152
   
  
• Proinsulin levels in patients with pancreatic diabetes are associated with functional changes in insulin secretion rather than pancreatic beta-cell area.
  Breuer TG, Menge BA, Banasch M, Uhl W, Tannapfel A, Schmidt WE, Nauck MA, Meier JJ
  Eur J Endocrinol. 2010
  PubMed ID: 20679359
   
  
• Insulin and glucose sensitivity, insulin secretion and beta-cell distribution in endocrine pancreas of the fruit bat Artibeus lituratus.
  Protzek AO, Rafacho A, Viscelli BA, Bosqueiro JR, Cappelli AP, Paula FM, Boschero AC, Pinheiro EC
  Comp Biochem Physiol A Mol Integr Physiol. 2010
  PubMed ID: 20566319
   
  
• Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
  Valtat B, Dupuis C, Zenaty D, Singh-Estivalet A, Tronche F, Bréant B, Blondeau B
  Diabetologia. 2010
  PubMed ID: 20857084
   
  
• A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.
  Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T
  Exp Cell Res. 2010
  PubMed ID: 20478304
   
  
• Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.
  Støy J, Steiner DF, Park SY, Ye H, Philipson LH, Bell GI
  Rev Endocr Metab Disord. 2010
  PubMed ID: 20938745
   
  
• Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years.
  Andersen MK, Lundgren V, Turunen JA, Forsblom C, Isomaa B, Groop PH, Groop L, Tuomi T
  Diabetes Care. 2010
  PubMed ID: 20805278
   
  
• Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture.
  Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS
  Diabetes. 2010
  PubMed ID: 20547975
   
  
• PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.
  Gupta S, McGrath B, Cavener DR
  Diabetes. 2010
  PubMed ID: 20530744
   
  
• Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice.
  Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED
  Endocrinology. 2010
  PubMed ID: 20501666
   
  
• Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
  Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR study group, Worthington J, Thomson W
  Ann Rheum Dis. 2010
  PubMed ID: 20647273
   
  
• Allele-specific recognition of the 3' splice site of INS intron 1.
  Kralovicova J, Vorechovsky I
  Hum Genet. 2010
  PubMed ID: 20628762
   
  
• MafA and MafB Regulate Genes Critical to {beta} Cells in a Unique Temporal Manner.
  Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R
  Diabetes. 2010
  PubMed ID: 20627934
   
  
• G{alpha}o represses insulin secretion by reducing vesicular docking in pancreatic {beta} cells.
  Zhao A, Ohara-Imaizumi M, Brissova M, Benniger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G
  Diabetes. 2010
  PubMed ID: 20622165
   
  
• The association of variable number of tandem repeats of the insulin gene with susceptibility to type 1 diabetes among Korean subjects.
  Chung HR, Yang SW, Shin CH, Park KS, Lee YA, Kim JH, Lee SH, Kim JH
  Diabetes Metab Res Rev. 2010
  PubMed ID: 20607677
   
  
• Impact of integrin-matrix interaction and signaling on insulin gene expression and the mesenchymal transition of human beta-cells.
  Kaido TJ, Yebra M, Kaneto H, Cirulli V, Hayek A, Montgomery AM
  J Cell Physiol. 2010
  PubMed ID: 20232313
   
  
• Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.
  Schaffer AE, Freude KK, Nelson SB, Sander M
  Dev Cell. 2010
  PubMed ID: 20627083
   
  
• In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
  Qu HQ, Bradfield JP, Li Q, Kim C, Frackelton E, Grant SF, Hakonarson H, Polychronakos C
  Hum Mol Genet. 2010
  PubMed ID: 20378605
   
  
• Risk of autoimmune diabetes in APECED: association with short alleles of the 5'insulin VNTR.
  Paquette J, Varin DS, Hamelin CE, Hallgren A, Kämpe O, Carel JC, Perheentupa J, Deal CL
  Genes Immun. 2010
  PubMed ID: 20535137
   
  
• N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
  Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H
  Genesis. 2010
  PubMed ID: 20533404
   
  
• Glial cell line-derived neurotrophic factor enhances neurogenin3 gene expression and {beta}-cell proliferation in the developing mouse pancreas.
  Mwangi SM, Usta Y, Raja SM, Anitha M, Chandrasekharan B, Parsadanian A, Sitaraman SV, Srinivasan S
  Am J Physiol Gastrointest Liver Physiol. 2010
  PubMed ID: 20448145
   
  
• Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function.
  Lau J, Hebrok M
  Diabetes. 2010
  PubMed ID: 20185815
   
  
• The transcription factor Rfx3 regulates {beta}-cell differentiation, function and glucokinase expression.
  Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W
  Diabetes. 2010
  PubMed ID: 20413507
   
  
• ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.
  Zito E, Chin KT, Blais J, Harding HP, Ron D
  J Cell Biol. 2010
  PubMed ID: 20308425
   
  
• Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.
  Panda AC, Kulkarni SD, Muralidharan B, Bakthavachalu B, Seshadri V
  FEBS Lett. 2010
  PubMed ID: 20153322
   
  
• Changes in frequency of IDDM-associated HLA DQB, CTLA4 and INS alleles.
  Witas HW, Jędrychowska-Dańska K, Zawicki P
  Int J Immunogenet. 2010
  PubMed ID: 20345871
   
  
• Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
  Yang Y, Hua QX, Liu J, Shimizu EH, Choquette MH, Mackin RB, Weiss MA
  J Biol Chem. 2010
  PubMed ID: 20106974
   
  
• Insulin gene VNTR genotype associates with frequency and phenotype of the autoimmune response to proinsulin.
  Durinovic-Belló I, Wu RP, Gersuk VH, Sanda S, Shilling HG, Nepom GT
  Genes Immun. 2010
  PubMed ID: 20054344
   
  
• Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.
  Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, del Castillo G, Deeb A, Deiss D, Fernandez JM, Godbole K, Hussain K, O'Connell M, Klupa T, Kolouskova S, Mohsin F, Perlman K, Sumnik Z, Rial JM, Ugarte E, Vasanthi T, Neonatal Diabetes International Group, Johnstone K, Flanagan SE, Martínez R, Castaño C, Patch AM, Fernández-Rebollo E, Raile K, Morgan N, Harries LW, Castaño L, Ellard S, Ferrer J, Perez de Nanclares G, Hattersley AT
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20133622
   
  
• Rfx6 directs islet formation and insulin production in mice and humans.
  Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Eijnden SV, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS
  Nature. 2010
  PubMed ID: 20148032
   
  
• Characterization of insulin ILPR sequences for their ability to adopt a G-quadruplex structure.
  Paritala H, Firestine SM
  Nucleosides Nucleotides Nucleic Acids. 2010
  PubMed ID: 20391195
   
  
• High affinity binding of hydrophobic and autoantigenic regions of proinsulin to the 70 kDa chaperone DnaK.
  Burkart V, Siegenthaler RK, Blasius E, Vandenbroeck K, Alloza I, Fingberg W, Schloot NC, Christen P, Kolb H
  BMC Biochem. 2010
  PubMed ID: 21059249
   
  
• Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.
  Liu M, Haataja L, Wright J, Wickramasinghe NP, Hua QX, Phillips NF, Barbetti F, Weiss MA, Arvan P
  PLoS One. 2010
  PubMed ID: 20948967
   
  
• Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies.
  Pörksen S, Laborie LB, Nielsen L, Louise Max Andersen M, Sandal T, de Wet H, Schwarcz E, Aman J, Swift P, Kocova M, Schönle EJ, de Beaufort C, Hougaard P, Ashcroft F, Molven A, Knip M, Mortensen HB, Hansen L, Njølstad PR, Hvidøre Study Group on Childhood Diabetes
  BMC Endocr Disord. 2010
  PubMed ID: 20863361
   
  
• Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.
  Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J
  Eur J Histochem. 2010
  PubMed ID: 20558340
   
  
• Global transcriptional programs in peripheral nerve endoneurium and DRG are resistant to the onset of type 1 diabetic neuropathy in Ins2 mice.
  de Preux Charles AS, Verdier V, Zenker J, Peter B, Médard JJ, Kuntzer T, Beckmann JS, Bergmann S, Chrast R
  PLoS One. 2010
  PubMed ID: 20520806
   
  
• Relative roles of the different Pax6 domains for pancreatic alpha cell development.
  Dames P, Puff R, Weise M, Parhofer KG, Göke B, Götz M, Graw J, Favor J, Lechner A
  BMC Dev Biol. 2010
  PubMed ID: 20377917
   
  
• Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas.
  Kopinke D, Murtaugh LC
  BMC Dev Biol. 2010
  PubMed ID: 20377894
   
  
• C-peptide as a therapeutic tool in diabetic nephropathy.
  Hills CE, Brunskill NJ, Squires PE
  Am J Nephrol. 2010
  PubMed ID: 20357430
   
  
• Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY).
  Boesgaard TW, Pruhova S, Andersson EA, Cinek O, Obermannova B, Lauenborg J, Damm P, Bergholdt R, Pociot F, Pisinger C, Barbetti F, Lebl J, Pedersen O, Hansen T
  BMC Med Genet. 2010
  PubMed ID: 20226046
   
  
• Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
  Pierce BL, Ahsan H
  Hum Hered. 2010
  PubMed ID: 20203524
   
  
• SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.
  Li S, Francisco AB, Munroe RJ, Schimenti JC, Long Q
  BMC Dev Biol. 2010
  PubMed ID: 20170518
   
  
• Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.
  Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G
  Development. 2010
  PubMed ID: 20040487
   
  
• Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
  Klinker MW, Schiller JJ, Magnuson VL, Wang T, Basken J, Veth K, Pearce KI, Kinnunen L, Harjutsalo V, Wang X, Tuomilehto J, Sarti C, Ghosh S
  Immunogenetics. 2009
  PubMed ID: 20033399
   
  
• Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas.
  Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G
  Dev Biol. 2009
  PubMed ID: 20025861
   
  
• Insulin gene mutations resulting in a MODY phenotype: marked differences in clinical presentation, metabolic status and pathogenic effect through ER retention.
  Meur G, Simon A, Harun N, Virally M, Dechaume A, Bonnefond A, Fetita S, Tarasov AI, Guillausseau PJ, Boesgaard TW, Pedersen O, Hansen T, Polak M, Gautier JF, Froguel P, Rutter GA, Vaxillaire M
  Diabetes. 2009
  PubMed ID: 20007936
   
  
• Ins2 Deficiency Augments Spontaneous HLA-A*0201-Restricted T Cell Responses to Insulin.
  Jarchum I, Dilorenzo TP
  J Immunol. 2009
  PubMed ID: 19966211
   
  
• Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice.
  Matsuda T, Kido Y, Asahara SI, Kaisho T, Tanaka T, Hashimoto N, Shigeyama Y, Takeda A, Inoue T, Shibutani Y, Koyanagi M, Hosooka T, Matsumoto M, Inoue H, Uchida T, Koike M, Uchiyama Y, Akira S, Kasuga M
  J Clin Invest. 2009
  PubMed ID: 19955657
   
  
• Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function.
  Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z
  Am J Physiol Heart Circ Physiol. 2009
  PubMed ID: 19801494
   
  
• Insulin2 gene (Ins2) transcription by NOD bone marrow-derived cells does not influence autoimmune diabetes development in NOD-Ins2 knockout mice.
  Martin-Pagola A, Pileggi A, Zahr E, Vendrame F, Damaris Molano R, Snowhite I, Ricordi C, Eisenbarth GS, Nakayama M, Pugliese A
  Scand J Immunol. 2009
  PubMed ID: 19874548
   
  
• Pancreatic neurogenin 3-expressing cells are unipotent islet precursors.
  Desgraz R, Herrera PL
  Development. 2009
  PubMed ID: 19793886
   
  
• OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.
  Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A
  Diabetologia. 2009
  PubMed ID: 19882138
   
  
• Genetic heterogeneity in latent autoimmune diabetes (LADA) is linked to a varying degree of autoimmune activity. Results from the Nord-Trondelag Health Study.
  Pettersen E, Skorpen F, Kvaløy K, Midthjell K, Grill V
  Diabetes. 2009
  PubMed ID: 19833889
   
  
• Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.
  Smith R, Bacos K, Fedele V, Soulet D, Walz HA, Obermüller S, Lindqvist A, Björkqvist M, Klein P, Onnerfjord P, Brundin P, Mulder H, Li JY
  Hum Mol Genet. 2009
  PubMed ID: 19628478
   
  
• Transcription factor Glis3: a novel critical player in the regulation of pancreatic {beta}-cell development and insulin gene expression.
  Kang HS, Kim YS, Zeruth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Foley J, Jetten AM
  Mol Cell Biol. 2009
  PubMed ID: 19805515
   
  
• Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice.
  Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M
  Diabetologia. 2009
  PubMed ID: 19644667
   
  
• Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.
  Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ, Sosa-Pineda B
  Dev Biol. 2009
  PubMed ID: 19635472
   
  
• Insulin But Not Glucagon Gene is Silenced in Human Pancreas-derived Mesenchymal Stem Cells.
  Wilson LM, Wong SH, Yu N, Geras-Raaka E, Raaka BM, Gershengorn MC
  Stem Cells. 2009
  PubMed ID: 19785038
   
  
• Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.
  Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M
  Mech Dev. 2009
  PubMed ID: 19766716
   
  
• PANDER binds to the liver cell membrane and inhibits insulin signaling in HepG2 cells.
  Yang J, Wang C, Li J, Burkhardt BR, Robert-Cooperman CE, Wilson C, Gao Z, Wolf BA
  FEBS Lett. 2009
  PubMed ID: 19683528
   
  
• Thymus-specific deletion of insulin induces autoimmune diabetes.
  Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M
  EMBO J. 2009
  PubMed ID: 19680229
   
  
• Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) BY NkX2.2 and neurogenin 3.
  Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L
  J Biol Chem. 2009
  PubMed ID: 19759004
   
  
• Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
  Cras-Méneur C, Li L, Kopan R, Permutt MA
  Genes Dev. 2009
  PubMed ID: 19723764
   
  
• Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice.
  Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB
  Circ Res. 2009
  PubMed ID: 19423844
   
  
• Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
  Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ
  Cell Metab. 2009
  PubMed ID: 19583950
   
  
• Islet-1 is required for the maturation, proliferation and survival of the endocrine pancreas.
  Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL
  Diabetes. 2009
  PubMed ID: 19502415
   
  
• Tissue-Specific Remodeling of the Mitochondrial Proteome in Type 1 Diabetic Akita Mice.
  Bugger H, Chen D, Riehle C, Soto J, Theobald HA, Hu XX, Ganesan B, Weimer BC, Abel ED
  Diabetes. 2009
  PubMed ID: 19542201
   
  
• Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
  Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA
  Diabetes. 2009
  PubMed ID: 19542200
   
  
• Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
  Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19487660
   
  
• Prolonged exposure to insulin suppresses mitochondrial production in primary hepatocytes.
  Liu HY, Yehuda-Shnaidman E, Hong T, Han J, Pi J, Liu Z, Cao W
  J Biol Chem. 2009
  PubMed ID: 19336408
   
  
• Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
  Hua QX, Xu B, Huang K, Hu SQ, Nakagawa S, Jia W, Wang S, Whittaker J, Katsoyannis PG, Weiss MA
  J Biol Chem. 2009
  PubMed ID: 19321436
   
  
• Decoding the Cryptic Active Conformation of a Protein by Synthetic Photoscanning: INSULIN INSERTS A DETACHABLE ARM BETWEEN RECEPTOR DOMAINS.
  Xu B, Huang K, Chu YC, Hu SQ, Nakagawa S, Wang S, Wang RY, Whittaker J, Katsoyannis PG, Weiss MA
  J Biol Chem. 2009
  PubMed ID: 19321435
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Elevation of fasting insulin and its association with cardiovascular disease risk in women with systemic lupus erythematosus.
  Tso TK, Huang WN
  Rheumatol Int. 2009
  PubMed ID: 19037607
   
  
• Type 1 diabetes susceptibility determined by HLA alleles and CTLA-4 and insulin genes polymorphisms in Brazilians.
  Ferreira AC, Gomes KB, Sampaio IB, de Oliveira VC, Pardini VC, Godard AL
  Arq Bras Endocrinol Metabol. 2009
  PubMed ID: 19578600
   
  
• Inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor gamma and thiazolidinedione oral antidiabetic drugs.
  Schinner S, Krätzner R, Baun D, Dickel C, Blume R, Oetjen E
  Br J Pharmacol. 2009
  PubMed ID: 19338578
   
  
• Residual structure in islet amyloid polypeptide mediates its interactions with soluble insulin.
  Wei L, Jiang P, Yau YH, Summer H, Shochat SG, Mu Y, Pervushin K
  Biochemistry. 2009
  PubMed ID: 19146426
   
  
• Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis.
  Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M
  Mol Endocrinol. 2009
  PubMed ID: 19131512
   
  
• Diminished pancreatic {beta} cell mass in securin-null mice is caused by {beta} cell apoptosis and senescence.
  Chesnokova V, Wong C, Zonis S, Gruszka A, Wawrowsky K, Ren SG, Benshlomo A, Yu R
  Endocrinology. 2009
  PubMed ID: 19213844
   
  
• Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?
  Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ
  Diabetes. 2009
  PubMed ID: 19188433
   
  
• AUTOIMMUNE THYROIDITIS AND DIABETES: DISSECTING THE JOINT GENETIC SUSCEPTIBILITY IN A LARGE COHORT OF MULTIPLEX FAMILIES.
  Villano MJ, Huber AK, Greenberg DA, Golden BK, Concepcion E, Tomer Y
  J Clin Endocrinol Metab. 2009
  PubMed ID: 19141582
   
  
• Insulin gene expression is regulated by DNA methylation.
  Kuroda A, Rauch TA, Todorov I, Ku HT, Al-Abdullah IH, Kandeel F, Mullen Y, Pfeifer GP, Ferreri K
  PLoS One. 2009
  PubMed ID: 19742322
   
  
• The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load.
  Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen TS, Pisinger C, Borch-Johnsen K, Sandbaek A, Lauritzen T, Brunak S, Maeda S, Hansen T, Pedersen O
  PLoS One. 2009
  PubMed ID: 19516902
   
  
• Rac1 regulates pancreatic islet morphogenesis.
  Greiner TU, Kesavan G, Ståhlberg A, Semb H
  BMC Dev Biol. 2009
  PubMed ID: 19126201
   
  
• Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.
  Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL
  Gastroenterology. 2009
  PubMed ID: 19022256
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
  Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH
  Genes Dev. 2008
  PubMed ID: 19141476
   
  
• Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor.
  Root-Bernstein R
  J Mol Recognit. 2008
  PubMed ID: 19051206
   
  
• Intravenous administration of proinsulin 1 or 2-expressing fiber-mutant recombinant adenovirus vector protects against the development of diabetes in NOD mice.
  Yamada K, Moriyama H, Okumachi Y, Arai T, Kameno M, Kishi M, Yasuda H, Hara K, Yokono K, Nagata M
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120291
   
  
• Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients.
  Bakhtadze E, Cervin C, Lindholm E, Borg H, Nilsson P, Arnqvist HJ, Bolinder J, Eriksson JW, Gudbjörnsdottir S, Nyström L, Agardh CD, Landin-Olsson M, Sundkvist G, Groop LC
  Diabetologia. 2008
  PubMed ID: 18839133
   
  
• Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells.
  Cifarelli V, Luppi P, Tse HM, He J, Piganelli J, Trucco M
  Atherosclerosis. 2008
  PubMed ID: 18294642
   
  
• Cx36 makes channels coupling human pancreatic {beta} - cells, and correlates with insulin expression.
  Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P
  Hum Mol Genet. 2008
  PubMed ID: 19000992
   
  
• A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
  Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M
  Dev Biol. 2008
  PubMed ID: 18723011
   
  
• Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.
  Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED
  Diabetes. 2008
  PubMed ID: 18678617
   
  
• Effect of polymorphism in insulin locus and HLA on type 1 diabetes in four ethnic groups in Israel.
  Benedek G, Brautbar C, Vardi P, Sharon N, Weintrob N, Zung A, Israel S
  Tissue Antigens. 2008
  PubMed ID: 19000139
   
  
• Insulin gene is a target in activin receptor-like kinase 7 signaling pathway in pancreatic beta-cells.
  Watanabe R, Shen ZP, Tsuda K, Yamada Y
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18951876
   
  
• Association of Type 1 Diabetes with Two Loci on 12q13 and 16p13 and the Influence Coexisting Thyroid Autoimmunity in Japanese.
  Awata T, Kawasaki E, Tanaka S, Ikegami H, Maruyama T, Shimada A, Nakanishi K, Kobayashi T, Iizuka H, Uga M, Kawabata Y, Kanazawa Y, Kurihara S, Osaki M, Katayama S, on behalf of the Japanese Study Group on Type 1 Diabetes Genetics
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18940880
   
  
• Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
  Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ
  J Clin Invest. 2008
  PubMed ID: 18776938
   
  
• Conditional inactivation of Myc impairs development of the exocrine pancreas.
  Nakhai H, Siveke JT, Mendoza-Torres L, Schmid RM
  Development. 2008
  PubMed ID: 18715949
   
  
• Diagnosis and treatment of neonatal diabetes: a United States experience.
  Støy J, Greeley SA, Paz VP, Ye H, Pastore AN, Skowron KB, Lipton RB, Cogen FR, Bell GI, Philipson LH, United States Neonatal Diabetes Working Group
  Pediatr Diabetes. 2008
  PubMed ID: 18662362
   
  
• Tumour suppressor MENIN is essential for development ofthe pancreatic endocrine cells.
  Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang C
  J Endocrinol. 2008
  PubMed ID: 18772165
   
  
• Increased superoxide contributes to enhancement of vascular contraction in Ins2(Akita) diabetic mice, an autosomal dominant mutant model.
  Yang XQ, Wang YY, Chen AF
  Clin Exp Pharmacol Physiol. 2008
  PubMed ID: 18788099
   
  
• Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression.
  Kim ST, Moley KH
  Reproduction. 2008
  PubMed ID: 18558660
   
  
• Conditional ablation of Notch signaling in pancreatic development.
  Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM
  Development. 2008
  PubMed ID: 18635610
   
  
• A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
  Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL
  Diabetologia. 2008
  PubMed ID: 18563383
   
  
• The mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3 null mouse.
  Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC
  Diabetes. 2008
  PubMed ID: 18599526
   
  
• Postnatal expansion of the pancreatic {beta}-cell mass is dependent on survivin.
  Jiang Y, Nishimura W, Devor-Henneman D, Kusewitt D, Wang H, Holloway MP, Dohi T, Sabo E, Robinson ML, Altieri DC, Sharma A, Altura RA
  Diabetes. 2008
  PubMed ID: 18599523
   
  
• Decreased Fetal Size is Associated with Beta Cell Hyperfunction in Early Life and Failure with Age.
  Chakravarthy MV, Zhu Y, Wice MB, Coleman T, Pappan KL, Marshall CA, McDaniel ML, Semenkovich CF
  Diabetes. 2008
  PubMed ID: 18591393
   
  
• Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice.
  Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S
  Diabetes. 2008
  PubMed ID: 18591390
   
  
• Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.
  Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M
  Dev Biol. 2008
  PubMed ID: 18452912
   
  
• Identification of transcripts with enriched expression in the developing and adult pancreas.
  Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones S, Marra MA, Helgason CD
  Genome Biol. 2008
  PubMed ID: 18554416
   
  
• Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion.
  Edfalk S, Steneberg P, Edlund H
  Diabetes. 2008
  PubMed ID: 18519800
   
  
• Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus.
  Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O, Hansen T, Federici L, Pesavento R, Cadario F, Federici G, Ghirri P, Arvan P, Iafusco D, Barbetti F, the Early Onset Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (SIEDP)
  J Clin Invest. 2008
  PubMed ID: 18451997
   
  
• Dendrite remodeling and other abnormalities in the retinal ganglion cells of Ins2 Akita diabetic mice.
  Gastinger MJ, Kunselman AR, Conboy EE, Bronson SK, Barber AJ
  Invest Ophthalmol Vis Sci. 2008
  PubMed ID: 18515593
   
  
• Signals from the neural crest regulate beta-cell mass in the pancreas.
  Nekrep N, Wang J, Miyatsuka T, German MS
  Development. 2008
  PubMed ID: 18506029
   
  
• Identification of ALOX5 as a gene regulating adiposity and pancreatic function.
  Mehrabian M, Schulthess FT, Nebohacova M, Castellani LW, Zhou Z, Hartiala J, Oberholzer J, Lusis AJ, Maedler K, Allayee H
  Diabetologia. 2008
  PubMed ID: 18421434
   
  
• Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.
  Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A
  Gastroenterology. 2008
  PubMed ID: 18471525
   
  
• Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes.
  Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, Tuomi T, Cilio CM, Groop L
  Diabetes. 2008
  PubMed ID: 18310307
   
  
• Identification of an INSM1 Binding Site in the Insulin Promoter: Negative Regulation of the Insulin Gene Transcription.
  Wang HW, Muguira M, Liu WD, Zhang T, Chen C, Aucoin R, Breslin M, Lan M
  J Endocrinol. 2008
  PubMed ID: 18417529
   
  
• Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.
  Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA
  Dev Biol. 2008
  PubMed ID: 18294628
   
  
• Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes.
  Bjørnvold M, Undlien DE, Joner G, Dahl-Jørgensen K, Njølstad PR, Akselsen HE, Gervin K, Rønningen KS, Stene LC
  Diabetologia. 2008
  PubMed ID: 18292987
   
  
• HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients.
  Cejkova P, Novota P, Cerna M, Kolostova K, Novakova D, Kucera P, Novak J, Andel M, Weber P, Zdarsky E
  Int J Immunogenet. 2008
  PubMed ID: 18279373
   
  
• Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
  Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA
  Mol Cell Biol. 2008
  PubMed ID: 18227155
   
  
• Mice with beta cell overexpression of glycogen synthase kinase-3beta have reduced beta cell mass and proliferation.
  Liu Z, Tanabe K, Bernal-Mizrachi E, Permutt MA
  Diabetologia. 2008
  PubMed ID: 18219478
   
  
• Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.
  Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O, Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR
  Diabetes. 2008
  PubMed ID: 18192540
   
  
• Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group.
  Polak M, Dechaume A, Cavé H, Nimri R, Crosnier H, Sulmont V, de Kerdanet M, Scharfmann R, Lebenthal Y, Froguel P, Vaxillaire M, French ND (Neonatal Diabetes) Study Group
  Diabetes. 2008
  PubMed ID: 18171712
   
  
• Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood.
  Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI, Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S
  Diabetes. 2008
  PubMed ID: 18162506
   
  
• A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.
  Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L
  Biochem J. 2008
  PubMed ID: 18039179
   
  
• ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress.
  Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y
  Cell Metab. 2008
  PubMed ID: 18316032
   
  
• Proinsulin C-peptide constricts glomerular afferent arterioles in diabetic mice. A potential renoprotective mechanism.
  Nordquist L, Lai EY, Sjöquist M, Patzak A, Persson AE
  Am J Physiol Regul Integr Comp Physiol. 2008
  PubMed ID: 18077505
   
  
• Effects of raloxifene on insulin sensitivity, beta-cell function, and hepatic insulin extraction in normal postmenopausal women.
  Nagamani M, Szymajda A, Sepilian V, Urban RJ, Gilkison C
  Fertil Steril. 2008
  PubMed ID: 17586504
   
  
• Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
  Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A
  Dev Biol. 2008
  PubMed ID: 18199433
   
  
• pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.
  Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV
  Dev Biol. 2008
  PubMed ID: 18155690
   
  
• Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes.
  Stene LC, Thorsby PM, Berg JP, Rønningen KS, Joner G, Norwegian Childhood Diabetes Study Group
  Pediatr Diabetes. 2008
  PubMed ID: 18211635
   
  
• Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study.
  Cordovado SK, Zhao Y, Warram JH, Gong H, Anderson KL, Hendrix MM, Hancock LN, Cleary PA, Mueller PW
  Diabetes. 2008
  PubMed ID: 18039812
   
  
• Permanent neonatal diabetes mellitus due to a C96Y heterozygous mutation in the insulin gene. A case report.
  Ahamed A, Unnikrishnan AG, Pendsey SS, Nampoothiri S, Bhavani N, Praveen VP, Kumar H, Jayakumar RV, Nair V, Ellard S, Edghill EL
  JOP. 2008
  PubMed ID: 18981553
   
  
• Expression of Groucho/TLE proteins during pancreas development.
  Hoffman BG, Zavaglia B, Beach M, Helgason CD
  BMC Dev Biol. 2008
  PubMed ID: 18778483
   
  
• Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II.
  Ramos-Lopez E, Lange B, Kahles H, Willenberg HS, Meyer G, Penna-Martinez M, Reisch N, Hahner S, Seissler J, Badenhoop K
  BMC Med Genet. 2008
  PubMed ID: 18620562
   
  
• C-peptide and its C-terminal fragments improve erythrocyte deformability in type 1 diabetes patients.
  Hach T, Forst T, Kunt T, Ekberg K, Pfützner A, Wahren J
  Exp Diabetes Res. 2008
  PubMed ID: 18483566
   
  
• Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis.
  Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M
  PLoS ONE. 2008
  PubMed ID: 18297134
   
  
• The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells.
  Lipson KL, Ghosh R, Urano F
  PLoS ONE. 2008
  PubMed ID: 18286202
   
  
• The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas.
  Hamblet NS, Shi W, Vinik AI, Taylor-Fishwick DA
  Pancreas. 2008
  PubMed ID: 18192873
   
  
• Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
  Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B
  Dev Dyn. 2008
  PubMed ID: 18058910
   
  
• Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
  Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I
  Gene Expr Patterns. 2008
  PubMed ID: 17996499
   
  
• Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
  Chao CS, Loomis ZL, Lee JE, Sussel L
  Dev Biol. 2007
  PubMed ID: 17988662
   
  
• Pancreatic innervation in mouse development and beta-cell regeneration.
  Burris RE, Hebrok M
  Neuroscience. 2007
  PubMed ID: 18006238
   
  
• Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling.
  Hong EG, Jung DY, Ko HJ, Zhang Z, Ma Z, Jun JY, Kim JH, Sumner AD, Vary TC, Gardner TW, Bronson SK, Kim JK
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17911348
   
  
• The human insulin gene displays transcriptionally active epigenetic marks in islet-derived mesenchymal precursor cells in the absence of insulin expression.
  Mutskov V, Raaka BM, Felsenfeld G, Gershengorn MC
  Stem Cells. 2007
  PubMed ID: 17901401
   
  
• MicroRNA expression is required for pancreatic islet cell genesis in the mouse.
  Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS
  Diabetes. 2007
  PubMed ID: 17804764
   
  
• MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3.
  Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA
  Dev Biol. 2007
  PubMed ID: 17936263
   
  
• Decreased insulin secretion and insulin sensitivity are associated with liver function in subjects with fasting glucose between 100 and 109 mg/dL in Taiwanese population.
  Hsiao JY, Wang CL, Hsia PJ, Hsieh MC, Hsin SC, Lin KD, Shin SJ
  Pancreas. 2007
  PubMed ID: 18090240
   
  
• Type 1 diabetes risk analysis on dried blood spot samples from population-based newborns: design and feasibility of an unselected case-control study.
  Eising S, Svensson J, Skogstrand K, Nilsson A, Lynch K, Andersen PS, Lernmark A, Hougaard DM, Pociot F, Nørgaard-Pedersen B, Nerup J
  Paediatr Perinat Epidemiol. 2007
  PubMed ID: 17937736
   
  
• Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
  Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G
  Mech Dev. 2007
  PubMed ID: 17928203
   
  
• Association of fasting glucagon and proinsulin concentrations with insulin resistance.
  Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators
  Diabetologia. 2007
  PubMed ID: 17846745
   
  
• Effect of etanercept on insulin secretion and insulin sensitivity in a randomized trial with psoriatic patients at risk for developing type 2 diabetes mellitus.
  Martínez-Abundis E, Reynoso-von Drateln C, Hernández-Salazar E, González-Ortiz M
  Arch Dermatol Res. 2007
  PubMed ID: 17726611
   
  
• Decreased L-type Ca2+ current in cardiac myocytes of type 1 diabetic Akita mice due to reduced phosphatidylinositol 3-kinase signaling.
  Lu Z, Jiang YP, Xu XH, Ballou LM, Cohen IS, Lin RZ
  Diabetes. 2007
  PubMed ID: 17666471
   
  
• Proinsulin maturation, misfolding, and proteotoxicity.
  Liu M, Hodish I, Rhodes CJ, Arvan P
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17898179
   
  
• Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets.
  Goto Y, Nomura M, Tanaka K, Kondo A, Morinaga H, Okabe T, Yanase T, Nawata H, Takayanagi R, Li E
  Dev Dyn. 2007
  PubMed ID: 17849440
   
  
• Insulin VNTR I/III genotype is associated with autoantibodies against glutamic acid decarboxylase in newly diagnosed type 1 diabetes.
  Rajasalu T, Haller K, Salur L, Kisand K, Tillmann V, Schlosser M, Uibo R
  Diabetes Metab Res Rev. 2007
  PubMed ID: 17461431
   
  
• Insulin gene mutations as a cause of permanent neonatal diabetes.
  Støy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, Lipton RB, Greeley SA, Patch AM, Ellard S, Steiner DF, Hattersley AT, Philipson LH, Bell GI, Neonatal Diabetes International Collaborative Group
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17855560
   
  
• Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice.
  Moriyama H, Nagata M, Arai T, Okumachi Y, Yamada K, Kotani R, Yasuda H, Hara K, Yokono K
  Diabetes Res Clin Pract. 2007
  PubMed ID: 17459508
   
  
• Endocrine regulation of energy metabolism by the skeleton.
  Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G
  Cell. 2007
  PubMed ID: 17693256
   
  
• A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
  Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C
  Nature. 2007
  PubMed ID: 17632545
   
  
• Expression of mutant Ins2C96Y results in enhanced tubule formation causing enlargement of pre-Golgi intermediates of CHO cells.
  Fan JY, Roth J, Zuber C
  Histochem Cell Biol. 2007
  PubMed ID: 17647009
   
  
• Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury.
  Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW
  Am J Pathol. 2007
  PubMed ID: 17600118
   
  
• Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.
  Strom A, Bonal C, Ashery-Padan R, Hashimoto N, Campos ML, Trumpp A, Noda T, Kido Y, Real FX, Thorel F, Herrera PL
  Development. 2007
  PubMed ID: 17596282
   
  
• Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects.
  Jensen RA, Gilliam LK, Törn C, Landin-Olsson M, Karlsson FA, Palmer JP, Kockum I, Akesson K, Lernmark B, Lynch K, Breslow N, Lernmark A, Diabetes Incidence Study in Sweden (DISS) group
  J Diabetes Complications. 2007
  PubMed ID: 17616349
   
  
• Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity.
  Nakayama M, Beilke JN, Jasinski JM, Kobayashi M, Miao D, Li M, Coulombe MG, Liu E, Elliott JF, Gill RG, Eisenbarth GS
  J Clin Invest. 2007
  PubMed ID: 17607359
   
  
• The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
  Nelson SB, Schaffer AE, Sander M
  Development. 2007
  PubMed ID: 17537793
   
  
• Human Krüppel-like factor 11 inhibits human proinsulin promoter activity in pancreatic beta cells.
  Niu X, Perakakis N, Laubner K, Limbert C, Stahl T, Brendel MD, Bretzel RG, Seufert J, Päth G
  Diabetologia. 2007
  PubMed ID: 17479246
   
  
• Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells.
  Abderrahmani A, Niederhauser G, Favre D, Abdelli S, Ferdaoussi M, Yang JY, Regazzi R, Widmann C, Waeber G
  Diabetologia. 2007
  PubMed ID: 17437081
   
  
• A role of FRK in regulation of embryonal pancreatic beta cell formation.
  Akerblom B, Annerén C, Welsh M
  Mol Cell Endocrinol. 2007
  PubMed ID: 17416457
   
  
• TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas.
  Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK
  Dev Biol. 2007
  PubMed ID: 17418116
   
  
• Alterations of pancreatic beta-cell mass and islet number due to Ins2-controlled expression of Cre recombinase: RIP-Cre revisited; part 2.
  Pomplun D, Florian S, Schulz T, Pfeiffer AF, Ristow M
  Horm Metab Res. 2007
  PubMed ID: 17533574
   
  
• Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes.
  Awata T, Kawasaki E, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Iizuka H, Kurihara S, Osaki M, Uga M, Kawabata Y, Tanaka S, Kanazawa Y, Katayama S
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17341563
   
  
• Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.
  Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R
  Diabetes. 2007
  PubMed ID: 17303807
   
  
• Increased prevalence of VNTR III of the insulin gene in women with gestational diabetes mellitus (GDM).
  Litou H, Anastasiou E, Thalassinou L, Sarika HL, Philippou G, Alevizaki M
  Diabetes Res Clin Pract. 2007
  PubMed ID: 17011062
   
  
• Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.
  Kedees MH, Guz Y, Vuguin PM, Vargas C, Cui L, Steiner DF, Charron MJ, Teitelman G
  Dev Dyn. 2007
  PubMed ID: 17366624
   
  
• Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions.
  Hummel M, Marienfeld S, Huppmann M, Knopff A, Voigt M, Bonifacio E, Ziegler AG
  Diabetologia. 2007
  PubMed ID: 17310371
   
  
• Transgenic insulin released from G cells preferentially signals in the liver.
  Lu YC, Rozengurt E, Zhukova E
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17291451
   
  
• MafB is required for islet beta cell maturation.
  Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360442
   
  
• BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
  Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H
  Cell Metab. 2007
  PubMed ID: 17339028
   
  
• Glucose regulation of insulin gene transcription and pre-mRNA processing in human islets.
  Evans-Molina C, Garmey JC, Ketchum R, Brayman KL, Deng S, Mirmira RG
  Diabetes. 2007
  PubMed ID: 17327454
   
  
• ATF-2 stimulates the human insulin promoter through the conserved CRE2 sequence.
  Hay CW, Ferguson LA, Docherty K
  Biochim Biophys Acta. 2007
  PubMed ID: 17337306
   
  
• The role of the IDDM2 locus in the susceptibility of UK APS1 subjects to type 1 diabetes mellitus.
  Adamson KA, Cheetham TD, Kendall-Taylor P, Seckl JR, Pearce SH
  Int J Immunogenet. 2007
  PubMed ID: 17284223
   
  
• Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
  Doyle MJ, Loomis ZL, Sussel L
  Development. 2007
  PubMed ID: 17202186
   
  
• Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas.
  Rukstalis JM, Habener JF
  Gene Expr Patterns. 2007
  PubMed ID: 17185046
   
  
• Two insulin gene single nucleotide polymorphisms associated with type 1 diabetes risk in the Finnish and Swedish populations.
  Laine AP, Holmberg H, Nilsson A, Ortqvist E, Kiviniemi M, Vaarala O, Akerblom HK, Simell O, Knip M, Ludvigsson J, Ivarsson SA, Larsson K, Lernmark A, Ilonen J, Finnish Paediatric Diabetes Registry
  Dis Markers. 2007
  PubMed ID: 17473382
   
  
• Wnt/beta-catenin signaling is required for development of the exocrine pancreas.
  Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM
  BMC Dev Biol. 2007
  PubMed ID: 17222338
   
  
• Dominant-negative alpha-subunit of farnesyl- and geranyltransferase inhibits glucose-stimulated, but not KCl-stimulated, insulin secretion in INS 832/13 cells.
  Veluthakal R, Kaur H, Goalstone M, Kowluru A
  Diabetes. 2007
  PubMed ID: 17192483
   
  
• FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells.
  Arnaud-Dabernat S, Kritzik M, Kayali AG, Zhang YQ, Liu G, Ungles C, Sarvetnick N
  Diabetes. 2007
  PubMed ID: 17192470
   
  
• Transgenic expression of human INS gene in Ins1/Ins2 double knockout mice leads to insulin underproduction and diabetes in some male mice.
  Karaca M, Durel B, Languille L, Lamotte L, Tourrel-Cuzin C, Leroux L, Abou Sleymane G, Saint-Just S, Bucchini D, Ktorza A, Joshi RL
  Front Biosci. 2007
  PubMed ID: 17127405
   
  
• Renal prostaglandin E2 receptor (EP) expression profile is altered in streptozotocin and B6-Ins2Akita type I diabetic mice.
  Nasrallah R, Xiong H, Hébert RL
  Am J Physiol Renal Physiol. 2007
  PubMed ID: 16954344
   
  
• Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.
  Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL
  Dev Biol. 2006
  PubMed ID: 17049510
   
  
• PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
  Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
  Cell Metab. 2006
  PubMed ID: 17141632
   
  
• Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.
  Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B
  Diabetologia. 2006
  PubMed ID: 17001468
   
  
• Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway.
  Nakamura Y, Kaneto H, Miyatsuka T, Matsuoka TA, Matsuhisa M, Node K, Hori M, Yamasaki Y
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16996478
   
  
• Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.
  Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC
  Diabetes. 2006
  PubMed ID: 17065333
   
  
• p27 Regulates the transition of beta-cells from quiescence to proliferation.
  Georgia S, Bhushan A
  Diabetes. 2006
  PubMed ID: 17065330
   
  
• A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease.
  Awdeh ZL, Yunis EJ, Audeh MJ, Fici D, Pugliese A, Larsen CE, Alper CA
  J Autoimmun. 2006
  PubMed ID: 17052889
   
  
• Analysis of pancreatic endocrine development in GDF11-deficient mice.
  Dichmann DS, Yassin H, Serup P
  Dev Dyn. 2006
  PubMed ID: 16964608
   
  
• Proinsulin is encoded by an RNA splice variant in human blood myeloid cells.
  Narendran P, Neale AM, Lee BH, Ngui K, Steptoe RJ, Morahan G, Madsen O, Dromey JA, Jensen KP, Harrison LC
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 17053071
   
  
• Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
  Shen Y, Joachimiak A, Rosner MR, Tang WJ
  Nature. 2006
  PubMed ID: 17051221
   
  
• Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.
  Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV
  Dev Biol. 2006
  PubMed ID: 16962573
   
  
• Gata6 is an important regulator of mouse pancreas development.
  Decker K, Goldman DC, Grasch CL, Sussel L
  Dev Biol. 2006
  PubMed ID: 16887115
   
  
• Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
  Ikegami H, Fujisawa T, Kawabata Y, Noso S, Ogihara T
  Ann N Y Acad Sci. 2006
  PubMed ID: 17130532
   
  
• Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis.
  Miralles F, Hebrard S, Lamotte L, Durel B, Gilgenkrantz H, Li Z, Daegelen D, Tuil D, Joshi RL
  Lab Invest. 2006
  PubMed ID: 16894357
   
  
• Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.
  Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA
  Gene Expr Patterns. 2006
  PubMed ID: 16750430
   
  
• The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3.
  Xu Y, Wang S, Zhang J, Zhao A, Stanger BZ, Gu G
  Dev Biol. 2006
  PubMed ID: 16920096
   
  
• The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
  Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C
  Genes Dev. 2006
  PubMed ID: 16951258
   
  
• Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.
  Proctor G, Jiang T, Iwahashi M, Wang Z, Li J, Levi M
  Diabetes. 2006
  PubMed ID: 16936198
   
  
• The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype.
  Stene LC, Thorsby PM, Berg JP, Rønningen KS, Undlien DE, Joner G, Norwegian Childhood Diabetes Study Group
  Diabetologia. 2006
  PubMed ID: 16691379
   
  
• Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
  Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G
  Endocrinology. 2006
  PubMed ID: 16627579
   
  
• The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.
  Dai FF, Zhang Y, Kang Y, Wang Q, Gaisano HY, Braunewell KH, Chan CB, Wheeler MB
  J Biol Chem. 2006
  PubMed ID: 16731532
   
  
• The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.
  Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M
  Mol Endocrinol. 2006
  PubMed ID: 16556734
   
  
• Transgenic insulin (B:9-23) T-cell receptor mice develop autoimmune diabetes dependent upon RAG genotype, H-2g7 homozygosity, and insulin 2 gene knockout.
  Jasinski JM, Yu L, Nakayama M, Li MM, Lipes MA, Eisenbarth GS, Liu E
  Diabetes. 2006
  PubMed ID: 16804066
   
  
• Tolerance to proinsulin-2 is due to radioresistant thymic cells.
  Faideau B, Lotton C, Lucas B, Tardivel I, Elliott JF, Boitard C, Carel JC
  J Immunol. 2006
  PubMed ID: 16785498
   
  
• The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
  Desai M, Zeggini E, Horton VA, Owen KR, Hattersley AT, Levy JC, Hitman GA, Walker M, Holman RR, McCarthy MI, Clark A
  Diabetes. 2006
  PubMed ID: 16731859
   
  
• Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes.
  Hermann R, Lipponen K, Kiviniemi M, Kakko T, Veijola R, Simell O, Knip M, Ilonen J
  Diabetologia. 2006
  PubMed ID: 16614815
   
  
• A new model of insulin-deficient diabetes: male NOD mice with a single copy of Ins1 and no Ins2.
  Babaya N, Nakayama M, Moriyama H, Gianani R, Still T, Miao D, Yu L, Hutton JC, Eisenbarth GS
  Diabetologia. 2006
  PubMed ID: 16612590
   
  
• Association analysis of the AIRE and insulin genes in Finnish type 1 diabetic patients.
  Turunen JA, Wessman M, Forsblom C, Kilpikari R, Parkkonen M, Pöntynen N, Ilmarinen T, Ulmanen I, Peltonen L, Groop PH
  Immunogenetics. 2006
  PubMed ID: 16552513
   
  
• A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
  Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A
  Dev Biol. 2006
  PubMed ID: 16580660
   
  
• Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4.
  Ahmedov G, Ahmedova L, Sedlakova P, Cinek O
  Pediatr Diabetes. 2006
  PubMed ID: 16629714
   
  
• Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
  Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
  Mol Cell Biol. 2006
  PubMed ID: 16537919
   
  
• IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
  Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H
  EMBO J. 2006
  PubMed ID: 16511571
   
  
• Parallel signaling pathways of melatonin in the pancreatic beta-cell.
  Peschke E, Bach AG, Mühlbauer E
  J Pineal Res. 2006
  PubMed ID: 16441556
   
  
• MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
  Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R
  Diabetes. 2006
  PubMed ID: 16443760
   
  
• Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.
  Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK
  PLoS Biol. 2006
  PubMed ID: 16435884
   
  
• Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
  Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV
  Genes Dev. 2006
  PubMed ID: 16418487
   
  
• Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
  Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K
  Cell Metab. 2006
  PubMed ID: 16399505
   
  
• Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2?
  Královicová J, Gaunt TR, Rodriguez S, Wood PJ, Day IN, Vorechovsky I
  Diabetes. 2006
  PubMed ID: 16380501
   
  
• Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.
  Nielsen LB, Mortensen HB, Chiarelli F, Holl R, Swift P, de Beaufort C, Pociot F, Hougaard P, Gammeltoft S, Knip M, Hansen L, Hvidøre Study Group
  Diabetologia. 2006
  PubMed ID: 16307231
   
  
• Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mist1.
  Fazio EN, Everest M, Colman R, Wang R, Pin CL
  J Endocrinol. 2005
  PubMed ID: 16423820
   
  
• Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus.
  Felner EI, Klitz W, Ham M, Lazaro AM, Stastny P, Dupont B, White PC
  Pediatr Diabetes. 2005
  PubMed ID: 16390390
   
  
• Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.
  Akpinar P, Kuwajima S, Krützfeldt J, Stoffel M
  Cell Metab. 2005
  PubMed ID: 16330324
   
  
• The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
  Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS
  Diabetes. 2005
  PubMed ID: 16306355
   
  
• Specific dynamic and noninvasive labeling of pancreatic beta cells in reporter mice.
  Ben-Yehudah A, Reinhart B, Navara C, Kotzuk J, Witchel S, Schatten G, Chaillet JR
  Genesis. 2005
  PubMed ID: 16283623
   
  
• Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout.
  Nakayama M, Babaya N, Miao D, Sikora K, Elliott JF, Eisenbarth GS
  J Autoimmun. 2005
  PubMed ID: 16289958
   
  
• Beta-catenin is essential for pancreatic acinar but not islet development.
  Murtaugh LC, Law AC, Dor Y, Melton DA
  Development. 2005
  PubMed ID: 16192304
   
  
• The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.
  Greenman IC, Gomez E, Moore CE, Herbert TP
  Biochem J. 2005
  PubMed ID: 15972000
   
  
• Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.
  Papadopoulou S, Edlund H
  Diabetes. 2005
  PubMed ID: 16186384
   
  
• Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
  Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A
  Curr Biol. 2005
  PubMed ID: 16169491
   
  
• The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity.
  Hermann R, Laine AP, Veijola R, Vahlberg T, Simell S, Lähde J, Simell O, Knip M, Ilonen J
  Diabetologia. 2005
  PubMed ID: 16025255
   
  
• Effect of insulin with concurrent amino acid infusion on protein metabolism in rapidly growing pubertal children with type 1 diabetes.
  Godil MA, Wilson TA, Garlick PJ, McNurlan MA
  Pediatr Res. 2005
  PubMed ID: 16006430
   
  
• Genetic analysis of families with autoimmune diabetes and thyroiditis: evidence for common and unique genes.
  Golden B, Levin L, Ban Y, Concepcion E, Greenberg DA, Tomer Y
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15928253
   
  
• The insulin gene in type 1 diabetes.
  Pugliese A
  IUBMB Life. 2005
  PubMed ID: 16081366
   
  
• Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology.
  Hassainya Y, Garcia-Pons F, Kratzer R, Lindo V, Greer F, Lemonnier FA, Niedermann G, van Endert PM
  Diabetes. 2005
  PubMed ID: 15983206
   
  
• Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis.
  Scheuner D, Vander Mierde D, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ
  Nat Med. 2005
  PubMed ID: 15980866
   
  
• NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.
  Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M
  Development. 2005
  PubMed ID: 15944193
   
  
• The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.
  Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A
  Development. 2005
  PubMed ID: 15930104
   
  
• Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets.
  Rosanas-Urgell A, Marfany G, Garcia-Fernàndez J
  Mol Cell Endocrinol. 2005
  PubMed ID: 15888377
   
  
• IRIS II study: intact proinsulin is confirmed as a highly specific indicator for insulin resistance in a large cross-sectional study design.
  Pfützner A, Standl E, Hohberg C, Konrad T, Strotmann HJ, Lübben G, Langenfeld MR, Schulze J, Forst T
  Diabetes Technol Ther. 2005
  PubMed ID: 15929679
   
  
• No evidence for genetically determined alteration in insulin secretion or sensitivity predisposing to type 1 diabetes: a study of identical twins.
  Hawa MI, Bonfanti R, Valeri C, Delli Castelli M, Beyan H, Leslie RD
  Diabetes Care. 2005
  PubMed ID: 15920061
   
  
• The Ins2Akita mouse as a model of early retinal complications in diabetes.
  Barber AJ, Antonetti DA, Kern TS, Reiter CE, Soans RS, Krady JK, Levison SW, Gardner TW, Bronson SK
  Invest Ophthalmol Vis Sci. 2005
  PubMed ID: 15914643
   
  
• Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells.
  Varadi A, Tsuboi T, Rutter GA
  Mol Biol Cell. 2005
  PubMed ID: 15788565
   
  
• Release of transgenic human insulin from gastric g cells: a novel approach for the amelioration of diabetes.
  Lu YC, Sternini C, Rozengurt E, Zhukova E
  Endocrinology. 2005
  PubMed ID: 15731364
   
  
• Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
  Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA
  Nature. 2005
  PubMed ID: 15889096
   
  
• Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
  Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS
  Nature. 2005
  PubMed ID: 15889095
   
  
• [Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas]
  Yan KM, Li AD, Yang HJ, Mei Y, Zhou HY
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005
  PubMed ID: 16736556
   
  
• Relaxin adenylyl cyclase system of pregnant women with diabetes: functional defects in insulin and relaxin adenylyl cyclase signaling systems in myometrium of pregnant women with type 1 diabetes.
  Kuznetsova L, Plesneva S, Shpakov A, Pertseva M
  Ann N Y Acad Sci. 2005
  PubMed ID: 15956745
   
  
• No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort.
  Bennett A, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Hartikainen AL, Franks S, Peltonen L, Elliott P, Järvelin MR, McCarthy MI
  Diabetologia. 2005
  PubMed ID: 15834700
   
  
• Maternal diabetes adversely affects preovulatory oocyte maturation, development, and granulosa cell apoptosis.
  Chang AS, Dale AN, Moley KH
  Endocrinology. 2005
  PubMed ID: 15718275
   
  
• Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum.
  Liu M, Li Y, Cavener D, Arvan P
  J Biol Chem. 2005
  PubMed ID: 15705595
   
  
• Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.
  Chu K, Tsai MJ
  Diabetes. 2005
  PubMed ID: 15793245
   
  
• Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.
  Asayesh A, Alanentalo T, Khoo NK, Ahlgren U
  Dev Dyn. 2005
  PubMed ID: 15739225
   
  
• Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
  Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M
  Diabetes. 2005
  PubMed ID: 15734845
   
  
• Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance.
  Minn AH, Lan H, Rabaglia ME, Harlan DM, Peculis BA, Attie AD, Shalev A
  Mol Endocrinol. 2005
  PubMed ID: 15550470
   
  
• Foxa2 is required for the differentiation of pancreatic alpha-cells.
  Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH
  Dev Biol. 2005
  PubMed ID: 15680365
   
  
• Longitudinal evaluation of memory performance and peripheral neuropathy in the Ins2C96Y Akita mice.
  Choeiri C, Hewitt K, Durkin J, Simard CJ, Renaud JM, Messier C
  Behav Brain Res. 2005
  PubMed ID: 15617768
   
  
• Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes.
  Hauache OM, Reis AF, Oliveira CS, Vieira JG, Sjöroos M, Ilonen J
  Dis Markers. 2005
  PubMed ID: 16276008
   
  
• Wnt5 signaling in vertebrate pancreas development.
  Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC
  BMC Biol. 2005
  PubMed ID: 16246260
   
  
• No association of INS-VNTR genotype and IAA autoantibodies.
  Pérez de Nanclares G, Bilbao JR, Castano L
  Ann N Y Acad Sci. 2004
  PubMed ID: 15699505
   
  
• Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes.
  Motzo C, Contu D, Cordell HJ, Lampis R, Congia M, Marrosu MG, Todd JA, Devoto M, Cucca F
  Diabetes. 2004
  PubMed ID: 15561961
   
  
• GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development.
  Harmon EB, Apelqvist AA, Smart NG, Gu X, Osborne DH, Kim SK
  Development. 2004
  PubMed ID: 15548585
   
  
• Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice.
  Mellitzer G, Martín M, Sidhoum-Jenny M, Orvain C, Barths J, Seymour PA, Sander M, Gradwohl G
  Mol Endocrinol. 2004
  PubMed ID: 15297605
   
  
• Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
  Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L
  Transgenic Res. 2004
  PubMed ID: 15587270
   
  
• Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.
  Georgia S, Bhushan A
  J Clin Invest. 2004
  PubMed ID: 15467835
   
  
• C-peptide: much more than a byproduct of insulin biosynthesis.
  Marques RG, Fontaine MJ, Rogers J
  Pancreas. 2004
  PubMed ID: 15367890
   
  
• Effects of C-peptide on expression of eNOS and iNOS in human cavernosal smooth muscle cells.
  Li H, Xu L, Dunbar JC, Dhabuwala CB, Sima AA
  Urology. 2004
  PubMed ID: 15351621
   
  
• Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.
  Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R R, Rutter GA, Kelsey G
  J Clin Invest. 2004
  PubMed ID: 15286800
   
  
• Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.
  Zhang YQ, Cleary MM, Si Y, Liu G, Eto Y, Kritzik M, Dabernat S, Kayali AG, Sarvetnick N
  Diabetes. 2004
  PubMed ID: 15277382
   
  
• Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice.
  Banaei-Bouchareb L, Gouon-Evans V, Samara-Boustani D, Castellotti MC, Czernichow P, Pollard JW, Polak M
  J Leukoc Biol. 2004
  PubMed ID: 15178709
   
  
• Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
  Cano DA, Murcia NS, Pazour GJ, Hebrok M
  Development. 2004
  PubMed ID: 15226261
   
  
• Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
  Barratt BJ, Payne F, Lowe CE, Hermann R, Healy BC, Harold D, Concannon P, Gharani N, McCarthy MI, Olavesen MG, McCormack R, Guja C, Ionescu-Tîrgovişte C, Undlien DE, Rønningen KS, Gillespie KM, Tuomilehto-Wolf E, Tuomilehto J, Bennett ST, Clayton DG, Cordell HJ, Todd JA
  Diabetes. 2004
  PubMed ID: 15220214
   
  
• Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.
  Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M
  Diabetes. 2004
  PubMed ID: 15220197
   
  
• T cells recognize multiple GAD65 and proinsulin epitopes in human type 1 diabetes, suggesting determinant spreading.
  Ott PA, Dittrich MT, Herzog BA, Guerkov R, Gottlieb PA, Putnam AL, Durinovic-Bello I, Boehm BO, Tary-Lehmann M, Lehmann PV
  J Clin Immunol. 2004
  PubMed ID: 15163889
   
  
• Identification of a novel PDX-1 binding site in the human insulin gene enhancer.
  Le Lay J, Matsuoka TA, Henderson E, Stein R
  J Biol Chem. 2004
  PubMed ID: 15028719
   
  
• Insulin gene profile cycles with season of birth of future diabetic children and their relatives.
  Mikulecký M, Minárik P, Michalková D
  J Pediatr Endocrinol Metab. 2004
  PubMed ID: 15237706
   
  
• Epidermal growth factor and insulin inhibit cell death in pancreatic beta cells by activation of PI3-kinase/AKT signaling pathway under oxidative stress.
  Maeda H, Rajesh KG, Maeda H, Suzuki R, Sasaguri S
  Transplant Proc. 2004
  PubMed ID: 15194403
   
  
• Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.
  Fajas L, Annicotte JS, Miard S, Sarruf D, Watanabe M, Auwerx J
  J Clin Invest. 2004
  PubMed ID: 15124020
   
  
• Genotypic and phenotypic differences between Arabian and Scandinavian women with gestational diabetes mellitus.
  Shaat N, Ekelund M, Lernmark A, Ivarsson S, Nilsson A, Perfekt R, Berntorp K, Groop L
  Diabetologia. 2004
  PubMed ID: 15095040
   
  
• Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice.
  Zuber C, Fan JY, Guhl B, Roth J
  FASEB J. 2004
  PubMed ID: 15033933
   
  
• Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.
  Rodríguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Miller GJ, Humphries SE, Day IN
  Hum Mol Genet. 2004
  PubMed ID: 14749349
   
  
• Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.
  Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 14970313
   
  
• Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.
  Zaiko M, Estreicher A, Ritz-Laser B, Herrera P, Favor J, Meda P, Philippe J
  Eur J Endocrinol. 2004
  PubMed ID: 15012626
   
  
• The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells.
  Nozaki J, Kubota H, Yoshida H, Naitoh M, Goji J, Yoshinaga T, Mori K, Koizumi A, Nagata K
  Genes Cells. 2004
  PubMed ID: 15005713
   
  
• The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
  Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B
  Dev Biol. 2004
  PubMed ID: 14729487
   
  
• The mechanism of insulin action on islet amyloid polypeptide fiber formation.
  Larson JL, Miranker AD
  J Mol Biol. 2004
  PubMed ID: 14659752
   
  
• Strong association of insulin gene INS-VNTR polymorphisms with type 1 diabetes in the Romanian population.
  Guja C, Guja L, Nutland S, Rance H, Todd JA, Ionescu-Tîrgovişte C
  Rom J Intern Med. 2004
  PubMed ID: 15529622
   
  
• [Association of insulin gene variants with type 1 diabetes mellitus in Czech population]
  Cinek O, Drevínek P, Sumník Z, Bendlová B, Vavrinec J
  Cas Lek Cesk. 2004
  PubMed ID: 15305767
   
  
• Variable number of tandem repeats of the insulin gene determines susceptibility to latent autoimmune diabetes in adults.
  Cerrone GE, Caputo M, Lopez AP, González C, Massa C, Cédola N, Targovnik HM, Frechtel GD
  Mol Diagn. 2004
  PubMed ID: 15230641
   
  
• Lack of support for a role of the insulin gene variable number of tandem repeats minisatellite (INS-VNTR) locus in fetal growth or type 2 diabetes-related intermediate traits in United Kingdom populations.
  Mitchell SM, Hattersley AT, Knight B, Turner T, Metcalf BS, Voss LD, Davies D, McCarthy A, Wilkin TJ, Smith GD, Ben-Shlomo Y, Frayling TM
  J Clin Endocrinol Metab. 2004
  PubMed ID: 14715866
   
  
• Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.
  Sumazaki R, Shiojiri N, Isoyama S, Masu M, Keino-Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A
  Nat Genet. 2004
  PubMed ID: 14702043
   
  
• Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice.
  Faideau B, Briand JP, Lotton C, Tardivel I, Halbout P, Jami J, Elliott JF, Krief P, Muller S, Boitard C, Carel JC
  J Immunol. 2004
  PubMed ID: 14688305
   
  
• Essential role of STAT3 in body weight and glucose homeostasis.
  Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li C
  Mol Cell Biol. 2004
  PubMed ID: 14673160
   
  
• Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
  Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA
  Development. 2004
  PubMed ID: 14660441
   
  
• The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.
  Laine AP, Hermann R, Knip M, Simell O, Akerblom HK, Ilonen J
  Tissue Antigens. 2004
  PubMed ID: 14651526
   
  
• 5'-Insulin gene VNTR polymorphism is specific for type 1 diabetes: no association with celiac or Addison's disease.
  Pérez De Nanclares G, Bilbao JR, Calvo B, Vitoria JC, Vázquez F, Castaño L
  Ann N Y Acad Sci. 2003
  PubMed ID: 14679083
   
  
• Opposing actions of Arx and Pax4 in endocrine pancreas development.
  Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P
  Genes Dev. 2003
  PubMed ID: 14561778
   
  
• Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas.
  Yoshida T, Tokunaga A, Nakao K, Okano H
  Differentiation. 2003
  PubMed ID: 14641329
   
  
• Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.
  Barroso I, Luan J, Middelberg RP, Harding AH, Franks PW, Jakes RW, Clayton D, Schafer AJ, O'Rahilly S, Wareham NJ
  PLoS Biol. 2003
  PubMed ID: 14551916
   
  
• Combined activities of hedgehog signaling inhibitors regulate pancreas development.
  Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M
  Development. 2003
  PubMed ID: 12917290
   
  
• Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse.
  Moriyama H, Abiru N, Paronen J, Sikora K, Liu E, Miao D, Devendra D, Beilke J, Gianani R, Gill RG, Eisenbarth GS
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12925730
   
  
• Of mice and MEN1: Insulinomas in a conditional mouse knockout.
  Crabtree JS, Scacheri PC, Ward JM, McNally SR, Swain GP, Montagna C, Hager JH, Hanahan D, Edlund H, Magnuson MA, Garrett-Beal L, Burns AL, Ried T, Chandrasekharappa SC, Marx SJ, Spiegel AM, Collins FS
  Mol Cell Biol. 2003
  PubMed ID: 12917331
   
  
• Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
  Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J
  Dev Biol. 2003
  PubMed ID: 12921743
   
  
• Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
  Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M
  Oncogene. 2003
  PubMed ID: 12917627
   
  
• Expression of Sox transcription factors in the developing mouse pancreas.
  Lioubinski O, Müller M, Wegner M, Sander M
  Dev Dyn. 2003
  PubMed ID: 12815626
   
  
• Ras-GRF1 signaling is required for normal beta-cell development and glucose homeostasis.
  Font de Mora J, Esteban LM, Burks DJ, Núñez A, Garcés C, García-Barrado MJ, Iglesias-Osma MC, Moratinos J, Ward JM, Santos E
  EMBO J. 2003
  PubMed ID: 12805218
   
  
• IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of Type 1 diabetes and associated autoimmunity.
  Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt BJ, Todd JA, Ziegler AG, Bonifacio E
  Diabetologia. 2003
  PubMed ID: 12750767
   
  
• NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children.
  Cinek O, Drevínek P, Sumník Z, Bendlová B, Sedláková P, Kolousková S, Snajderová M, Vavrinec J
  Diabetes Res Clin Pract. 2003
  PubMed ID: 12639765
   
  
• Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice.
  Thébault-Baumont K, Dubois-Laforgue D, Krief P, Briand JP, Halbout P, Vallon-Geoffroy K, Morin J, Laloux V, Lehuen A, Carel JC, Jami J, Muller S, Boitard C
  J Clin Invest. 2003
  PubMed ID: 12639991
   
  
• Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.
  Halban PA, Irminger JC
  Mol Biol Cell. 2003
  PubMed ID: 12631734
   
  
• Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse.
  Izumi T, Yokota-Hashimoto H, Zhao S, Wang J, Halban PA, Takeuchi T
  Diabetes. 2003
  PubMed ID: 12540615
   
  
• Ins1 gene up-regulated in a beta-cell line derived from Ins2 knockout mice.
  Leroux L, Durel B, Autier V, Deltour L, Bucchini D, Jami J, Joshi RL
  Int J Exp Diabesity Res. 2003
  PubMed ID: 12745665
   
  
• Disproportionately elevated fasting proinsulin levels in normoglycemic patients with thalassemia major are correlated to the degree of iron overload.
  Cario H, Holl RW, Debatin KM, Kohne E
  Horm Res. 2003
  PubMed ID: 12589110
   
  
• The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
  Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D
  J Clin Invest. 2002
  PubMed ID: 12488434
   
  
• Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes.
  Dubois-Lafforgue D, Mogenet L, Thébault K, Jami J, Krief P, Boitard C
  Diabetes. 2002
  PubMed ID: 12475795
   
  
• Proinsulin processing in the diabetic Goto-Kakizaki rat.
  Guest PC, Abdel-Halim SM, Gross DJ, Clark A, Poitout V, Amaria R, Ostenson CG, Hutton JC
  J Endocrinol. 2002
  PubMed ID: 12475375
   
  
• ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture.
  Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y, Otonkoski T
  Endocrinology. 2002
  PubMed ID: 12399441
   
  
• Proinsulin in girls: relationship to obesity, hyperinsulinemia, and puberty.
  Chin D, Oberfield SE, Silfen ME, McMahon DJ, Manibo AM, Accili D, Levine LS
  J Clin Endocrinol Metab. 2002
  PubMed ID: 12364457
   
  
• Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.
  Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D
  J Biol Chem. 2002
  PubMed ID: 12101187
   
  
• A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.
  Rizzo MA, Magnuson MA, Drain PF, Piston DW
  J Biol Chem. 2002
  PubMed ID: 12101177
   
  
• Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.
  Nammo T, Yamagata K, Hamaoka R, Zhu Q, Akiyama TE, Gonzalez FJ, Miyagawa J, Matsuzawa Y
  Diabetologia. 2002
  PubMed ID: 12189445
   
  
• A proinsulin gene splice variant with increased translation efficiency is expressed in human pancreatic islets.
  Shalev A, Blair PJ, Hoffmann SC, Hirshberg B, Peculis BA, Harlan DM
  Endocrinology. 2002
  PubMed ID: 12072386
   
  
• Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
  Wilson ME, Kalamaras JA, German MS
  Mech Dev. 2002
  PubMed ID: 12049785
   
  
• Association of insulin gene VNTR polymorphism with polycystic ovary syndrome.
  Vanková M, Vrbíková J, Hill M, Cinek O, Bendlová B
  Ann N Y Acad Sci. 2002
  PubMed ID: 12079889
   
  
• CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: a French case-control study and segregation analysis. Evidence of a maternal effect.
  Fajardy I, Vambergue A, Stuckens C, Weill J, Danze PM, Fontaine P
  Eur J Immunogenet. 2002
  PubMed ID: 12047362
   
  
• Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.
  Hussain MA, Miller CP, Habener JF
  J Biol Chem. 2002
  PubMed ID: 11834725
   
  
• Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
  Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM, Schaefer JB, Zarghami M, Day HL, Landin-Olsson M, Palmer JP, Janer-Villanueva M, Hood L, Sundkvist G, Lernmark A, Breslow N, Dahlquist G, Blohmé G, Diabetes Incidence in Sweden Study Group, Swedish Childhood Diabetes Study Group
  Diabetes. 2002
  PubMed ID: 11978629
   
  
• Insulin, but not proinsulin C-peptide, enhances platelet fibrinogen binding in vitro in Type 1 diabetes mellitus patients and healthy subjects.
  Hu H, Li N, Ekberg K, Johansson BL, Hjemdahl P
  Thromb Res. 2002
  PubMed ID: 12182905
   
  
• Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
  Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML
  Nat Genet. 2002
  PubMed ID: 11912494
   
  
• Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
  Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ
  Endocrinology. 2002
  PubMed ID: 11897712
   
  
• Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.
  Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E, Mori M
  J Clin Invest. 2002
  PubMed ID: 11854325
   
  
• Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse.
  Ron D
  J Clin Invest. 2002
  PubMed ID: 11854314
   
  
• [TNF-alpha PC-1 gene polymorphisms and pre-diabetes quantitative features in the Polish population]
  Wanic K, Małecki M, Klupa T, Witek P, Kozek E, Sieradzki J
  Przegl Lek. 2002
  PubMed ID: 12715715
   
  
• Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development.
  Li H, Edlund H
  Dev Biol. 2001
  PubMed ID: 11784060
   
  
• Low insulin resistance and preserved beta-cell function contribute to human longevity but are not associated with TH-INS genes.
  Paolisso G, Barbieri M, Rizzo MR, Carella C, Rotondi M, Bonafè M, Franceschi C, Rose G, De Benedictis G
  Exp Gerontol. 2001
  PubMed ID: 11738155
   
  
• Induction of pancreatic differentiation by signals from blood vessels.
  Lammert E, Cleaver O, Melton D
  Science. 2001
  PubMed ID: 11577200
   
  
• CTLA4 gene polymorphism contributes to the mode of onset of diabetes with antiglutamic acid decarboxylase antibody in Japanese patients: genetic analysis of diabetic patients with antiglutamic acid decarboxylase antibody.
  Abe T, Yamaguchi Y, Takino H, Fujita N, Yamauchi-Degawa M, Ozaki M, Yamakawa K, Sera Y, Sakamaki H, Uotani S, Kawasaki E, Awata T, Yamasaki H, Eguchi K
  Diabet Med. 2001
  PubMed ID: 11606170
   
  
• The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.
  Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T
  J Biol Chem. 2001
  PubMed ID: 11371557
   
  
• Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.
  Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, Goodyer CG, Polychronakos C
  J Clin Endocrinol Metab. 2001
  PubMed ID: 11502799
   
  
• Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
  Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ
  Mol Cell. 2001
  PubMed ID: 11430820
   
  
• Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
  Lee KH, Wucherpfennig KW, Wiley DC
  Nat Immunol. 2001
  PubMed ID: 11376336
   
  
• Concordance for type 1 diabetes in identical twins is affected by insulin genotype.
  Metcalfe KA, Hitman GA, Rowe RE, Hawa M, Huang X, Stewart T, Leslie RD
  Diabetes Care. 2001
  PubMed ID: 11347740
   
  
• Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.
  Leroux L, Desbois P, Lamotte L, Duvillié B, Cordonnier N, Jackerott M, Jami J, Bucchini D, Joshi RL
  Diabetes. 2001
  PubMed ID: 11272179
   
  
• The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity.
  Le Stunff C, Fallin D, Schork NJ, Bougnères P
  Nat Genet. 2000
  PubMed ID: 11101842
   
  
• Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
  Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M
  Development. 2000
  PubMed ID: 11076772
   
  
• Regulation of pancreas development by hedgehog signaling.
  Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA
  Development. 2000
  PubMed ID: 11044404
   
  
• Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell.
  Goodge KA, Hutton JC
  Semin Cell Dev Biol. 2000
  PubMed ID: 10966857
   
  
• Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
  Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS
  Development. 2000
  PubMed ID: 10903178
   
  
• Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression.
  Ban N, Yamada Y, Someya Y, Ihara Y, Adachi T, Kubota A, Watanabe R, Kuroe A, Inada A, Miyawaki K, Sunaga Y, Shen ZP, Iwakura T, Tsukiyama K, Toyokuni S, Tsuda K, Seino Y
  Diabetes. 2000
  PubMed ID: 10909971
   
  
• Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.
  Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV
  Development. 2000
  PubMed ID: 10851133
   
  
• Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing.
  Arias AE, Vélez-Granell CS, Mayer G, Bendayan M
  J Cell Sci. 2000
  PubMed ID: 10806118
   
  
• Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: implications for lineage selection.
  Maldonado TS, Kadison AS, Crisera CA, Grau JB, Alkasab SL, Longaker MT, Gittes GK
  J Gastrointest Surg. 2000
  PubMed ID: 10769089
   
  
• Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.
  Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P
  Diabetes. 2000
  PubMed ID: 10868931
   
  
• Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.
  Smith SB, Ee HC, Conners JR, German MS
  Mol Cell Biol. 1999
  PubMed ID: 10567552
   
  
• Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.
  Wang J, Takeuchi T, Yokota H, Izumi T
  J Biol Chem. 1999
  PubMed ID: 10497219
   
  
• Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.
  Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH
  Nat Genet. 1999
  PubMed ID: 10471502
   
  
• Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
  Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF
  Nat Genet. 1999
  PubMed ID: 10471495
   
  
• Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.
  Jiang FX, Cram DS, DeAizpurua HJ, Harrison LC
  Diabetes. 1999
  PubMed ID: 10102687
   
  
• Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
  Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC
  Diabetes. 1999
  PubMed ID: 10078553
   
  
• Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
  Kaestner KH, Katz J, Liu Y, Drucker DJ, Schütz G
  Genes Dev. 1999
  PubMed ID: 10049364
   
  
• Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets.
  Esni F, Täljedal IB, Perl AK, Cremer H, Christofori G, Semb H
  J Cell Biol. 1999
  PubMed ID: 9922458
   
  
• Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion.
  Lang J
  Eur J Biochem. 1999
  PubMed ID: 9914469
   
  
• A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse.
  Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D, Takata K, Koizumi A, Izumi T
  J Clin Invest. 1999
  PubMed ID: 9884331
   
  
• Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.
  Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P
  Dev Genet. 1999
  PubMed ID: 10079507
   
  
• The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.
  Krapp A, Knöfler M, Ledermann B, Bürki K, Berney C, Zoerkler N, Hagenbüchle O, Wellauer PK
  Genes Dev. 1998
  PubMed ID: 9851981
   
  
• In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos.
  Rausa FM, Ye H, Lim L, Duncan SA, Costa RH
  Methods. 1998
  PubMed ID: 9774514
   
  
• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
  Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS
  Development. 1998
  PubMed ID: 9584121
   
  
• Mapping of murine diabetogenic gene mody on chromosome 7 at D7Mit258 and its involvement in pancreatic islet and beta cell development during the perinatal period.
  Kayo T, Koizumi A
  J Clin Invest. 1998
  PubMed ID: 9593767
   
  
• The role of assembly in insulin's biosynthesis.
  Dodson G, Steiner D
  Curr Opin Struct Biol. 1998
  PubMed ID: 9631292
   
  
• The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.
  Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, Copeland NG, Costa RH
  Dev Biol. 1997
  PubMed ID: 9441664
   
  
• Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
  Sander M, Neubüser A, Kalamaras J, Ee HC, Martin GR, German MS
  Genes Dev. 1997
  PubMed ID: 9224716
   
  
• Phenotypic alterations in insulin-deficient mutant mice.
  Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier JM, Monthioux E, Jami J, Joshi RL, Bucchini D
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9144203
   
  
• A novel point mutation in the insulin gene giving rise to hyperproinsulinemia.
  Warren-Perry MG, Manley SE, Ostrega D, Polonsky K, Mussett S, Brown P, Turner RC
  J Clin Endocrinol Metab. 1997
  PubMed ID: 9141561
   
  
• The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.
  Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P
  Nature. 1997
  PubMed ID: 9121556
   
  
• Cadherins regulate aggregation of pancreatic beta-cells in vivo.
  Dahl U, Sjødin A, Semb H
  Development. 1996
  PubMed ID: 8787762
   
  
• Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos.
  Perfetti R, Raygada M, Wang Y, Zenilman ME, Egan JM, Denno KM, Sadler TW, Shuldiner AR
  J Mol Endocrinol. 1996
  PubMed ID: 8863190
   
  
• PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells.
  Chiang MK, Flanagan JG
  Development. 1996
  PubMed ID: 8681804
   
  
• The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.
  Ahlgren U, Jonsson J, Edlund H
  Development. 1996
  PubMed ID: 8625829
   
  
• Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors.
  Gittes GK, Galante PE, Hanahan D, Rutter WJ, Debase HT
  Development. 1996
  PubMed ID: 8625795
   
  
• A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells.
  Neophytou PI, Muir EM, Hutton JC
  Diabetes. 1996
  PubMed ID: 8549854
   
  
• Mouse R-cadherin: expression during the organogenesis of pancreas and gastrointestinal tract.
  Sjödin A, Dahl U, Semb H
  Exp Cell Res. 1995
  PubMed ID: 7493641
   
  
• Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis.
  Christofori G, Naik P, Hanahan D
  Nat Genet. 1995
  PubMed ID: 7663515
   
  
• Developmental biology of the pancreas.
  Slack JM
  Development. 1995
  PubMed ID: 7600975
   
  
• Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion.
  Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP, Boyd AE, González G, Herrera-Sosa H, Nguy K, Bryan J, Nelson DA
  Science. 1995
  PubMed ID: 7716547
   
  
• Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
  Malide D, Seidah NG, Chrétien M, Bendayan M
  J Histochem Cytochem. 1995
  PubMed ID: 7822759
   
  
• Insulin-promoter-factor 1 is required for pancreas development in mice.
  Jonsson J, Carlsson L, Edlund T, Edlund H
  Nature. 1994
  PubMed ID: 7935793
   
  
• Differential expression of non-allelic insulin genes in rodent islet tumour cells.
  Lund K, Blume N, Michelsen BK, Bucchini D, Madsen OD
  J Mol Endocrinol. 1993
  PubMed ID: 8148038
   
  
• IPF1, a homeodomain-containing transactivator of the insulin gene.
  Ohlsson H, Karlsson K, Edlund T
  EMBO J. 1993
  PubMed ID: 7901001
   
  
• Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR.
  Lucassen AM, Julier C, Beressi JP, Boitard C, Froguel P, Lathrop M, Bell JI
  Nat Genet. 1993
  PubMed ID: 8358440
   
  
• Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene.
  Herrera PL, Huarte J, Sanvito F, Meda P, Orci L, Vassalli JD
  Development. 1991
  PubMed ID: 1811941
   
  
• A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene.
  Walker MD, Park CW, Rosen A, Aronheim A
  Nucleic Acids Res. 1990
  PubMed ID: 2181401
   
  
• Localization of proinsulin and insulin in human insulinoma: preliminary immunohistochemical results.
  Roth J, Kasper M, Stamm B, Häcki WH, Storch MJ, Madsen OD, Klöppel G, Heitz PU
  Virchows Arch B Cell Pathol Incl Mol Pathol. 1989
  PubMed ID: 2565624
   
  
• Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance.
  Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte D
  Diabetologia. 1987
  PubMed ID: 3322910
   
  
• Effect of intravenous insulin treatment on in vivo whole body leucine kinetics and oxygen consumption in insulin-deprived type I diabetic patients.
  Nair KS, Ford GC, Halliday D
  Metabolism. 1987
  PubMed ID: 3553851
   
  
• The structure of rat preproinsulin genes.
  Lomedico PT, Rosenthal N, Kolodner R, Efstratiadis A, Gilbert W
  Ann N Y Acad Sci. 1980
  PubMed ID: 6249167
   
  
• A structurally abnormal insulin causing human diabetes.
  Tager H, Given B, Baldwin D, Mako M, Markese J, Rubenstein A, Olefsky J, Kobayashi M, Kolterman O, Poucher R
  Nature. 1979
  PubMed ID: 381941
   
  

Publications: 525

• Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes.
  Kim EY, Dryer SE
  J Cell Physiol. 2011
  PubMed ID: 21660954
   
  
• Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.
  Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV
  Genes Dev. 2011
  PubMed ID: 21852533
   
  
• Time-dependent changes in the plasma amino acid concentration in diabetes mellitus.
  Mochida T, Tanaka T, Shiraki Y, Tajiri H, Matsumoto S, Shimbo K, Ando T, Nakamura K, Okamoto M, Endo F
  Mol Genet Metab. 2011
  PubMed ID: 21636301
   
  
• Diabetes caused by insulin gene (INS) deletion: clinical characteristics of homozygous and heterozygous individuals.
  Raile K, O'Connell M, Galler A, Werther G, Kühnen P, Krude H, Blankenstein O
  Eur J Endocrinol. 2011
  PubMed ID: 21566073
   
  
• Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis.
  Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K
  J Immunol. 2011
  PubMed ID: 21646299
   
  
• An extended domain of Kcnq1ot1 silencing revealed by an imprinted fluorescent reporter.
  Jones MJ, Bogutz AB, Lefebvre L
  Mol Cell Biol. 2011
  PubMed ID: 21576366
   
  
• Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite.
  Fox R, Kim HS, Reddick RL, Kujoth GC, Prolla TA, Tsutsumi S, Wada Y, Smithies O, Maeda N
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21555558
   
  
• Structural and functional changes in human insulin induced by the lipid peroxidation byproducts 4-hydroxy-2-nonenal and 4-hydroxy-2-hexenal.
  Pillon NJ, Vella RE, Souleere L, Becchi M, Lagarde M, Soulage CO
  Chem Res Toxicol. 2011
  PubMed ID: 21462967
   
  
• Insulin-stimulated GLUT4 protein translocation in adipocytes requires the Rab10 guanine nucleotide exchange factor Dennd4C.
  Sano H, Peck GR, Kettenbach AN, Gerber SA, Lienhard GE
  J Biol Chem. 2011
  PubMed ID: 21454697
   
  
• AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane.
  Koumanov F, Richardson JD, Murrow BA, Holman GD
  J Biol Chem. 2011
  PubMed ID: 21454690
   
  
• Growth-limiting role of endothelial cells in endoderm development.
  Sand FW, Hörnblad A, Johansson JK, Lorén C, Edsbagge J, Ståhlberg A, Magenheim J, Ilovich O, Mishani E, Dor Y, Ahlgren U, Semb H
  Dev Biol. 2011
  PubMed ID: 21281624
   
  
• A novel domain of caveolin-2 that controls nuclear targeting: regulation of insulin-specific ERK activation and nuclear translocation by caveolin-2.
  Kwon H, Jeong K, Hwang EM, Park JY, Pak Y
  J Cell Mol Med. 2011
  PubMed ID: 20455999
   
  
• Protein disulfide isomerase isomerizes non-native disulfide bonds in human proinsulin independent of its peptide-binding activity.
  Winter J, Gleiter S, Klappa P, Lilie H
  Protein Sci. 2011
  PubMed ID: 21308844
   
  
• TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis.
  Huang H, Gandhi JK, Zhong X, Wei Y, Gong J, Duh EJ, Vinores SA
  Invest Ophthalmol Vis Sci. 2011
  PubMed ID: 21212173
   
  
• Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein.
  Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP
  Nat Med. 2011
  PubMed ID: 21258336
   
  
• A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy.
  Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21245338
   
  
• Redox regulation of insulin degradation by insulin-degrading enzyme.
  Cordes CM, Bennett RG, Siford GL, Hamel FG
  PLoS One. 2011
  PubMed ID: 21448434
   
  
• Oncogene activation induces metabolic transformation resulting in insulin-independence in human breast cancer cells.
  Bollig-Fischer A, Dewey TG, Ethier SP
  PLoS One. 2011
  PubMed ID: 21437235
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Novel adiponectin-resistin (AR) and insulin resistance (IRAR) indexes are useful integrated diagnostic biomarkers for insulin resistance, type 2 diabetes and metabolic syndrome: a case control study.
  Lau CH, Muniandy S
  Cardiovasc Diabetol. 2011
  PubMed ID: 21251282
   
  
• Paternally inherited proinsulin mutations may result in earlier onset of monogenic diabetes mutation identity effect in monogenic diabetes.
  Fendler W, Borowiec M, Antosik K, Jaroszewska-Swiatek B, Szwalkiewicz-Warowicka E, Malecki M, Mysliwiec M, Mlynarski W
  Diabetes Care. 2011
  PubMed ID: 21193618
   
  
• Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons.
  Ha Y, Dun Y, Thangaraju M, Duplantier J, Dong Z, Liu K, Ganapathy V, Smith SB
  Invest Ophthalmol Vis Sci. 2011
  PubMed ID: 20811050
   
  
• Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
  Kim ST, Cheng Y, Hsu FC, Jin T, Kader AK, Zheng SL, Isaacs WB, Xu J, Sun J
  Prostate. 2010
  PubMed ID: 20564319
   
  
• Insulin metabolism in human adipocytes from subcutaneous and visceral depots.
  Fawcett J, Sang H, Permana PA, Levy JL, Duckworth WC
  Biochem Biophys Res Commun. 2010
  PubMed ID: 21036154
   
  
• Characterization of a mouse model of hyperglycemia and retinal neovascularization.
  Rakoczy EP, Ali Rahman IS, Binz N, Li CR, Vagaja NN, de Pinho M, Lai CM
  Am J Pathol. 2010
  PubMed ID: 20829433
   
  
• A large-scale candidate gene association study of age at menarche and age at natural menopause.
  He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
  Hum Genet. 2010
  PubMed ID: 20734064
   
  
• Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?
  Fang RC, Kryger ZB, Buck Ii DW, De La Garza M, Galiano RD, Mustoe TA
  Wound Repair Regen. 2010
  PubMed ID: 20955341
   
  
• Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy.
  Mishra PK, Givvimani S, Metreveli N, Tyagi SC
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20836991
   
  
• Arp2/3- and cofilin-coordinated actin dynamics is required for insulin-mediated GLUT4 translocation to the surface of muscle cells.
  Chiu TT, Patel N, Shaw AE, Bamburg JR, Klip A
  Mol Biol Cell. 2010
  PubMed ID: 20739464
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
  Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP
  J Biol Chem. 2010
  PubMed ID: 20587420
   
  
• Structural features of proinsulin C-peptide oligomeric and amyloid states.
  Lind J, Lindahl E, Perálvarez-Marín A, Holmlund A, Jörnvall H, Mäler L
  FEBS J. 2010
  PubMed ID: 20738396
   
  
• Generation of mice with a conditional null allele for Wntless.
  Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA
  Genesis. 2010
  PubMed ID: 20614471
   
  
• Impaired pancreatic development in Hif2-alpha deficient mice.
  Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20678473
   
  
• Insulin and NPY pathways and the control of GnRH function and puberty onset.
  Pralong FP
  Mol Cell Endocrinol. 2010
  PubMed ID: 20138117
   
  
• Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.
  Bonnesen C, Nelander GM, Hansen BF, Jensen P, Krabbe JS, Jensen MB, Hegelund AC, Svendsen JE, Oleksiewicz MB
  Cell Biol Toxicol. 2010
  PubMed ID: 19898946
   
  
• Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.
  Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G
  Cell. 2010
  PubMed ID: 20655470
   
  
• Association study of 182 candidate genes in anorexia nervosa.
  Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
  Am J Med Genet B Neuropsychiatr Genet. 2010
  PubMed ID: 20468064
   
  
• Redox modulation protects islets from transplant-related injury.
  Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, Piganelli JD
  Diabetes. 2010
  PubMed ID: 20413509
   
  
• Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice.
  Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20479236
   
  
• Wide-angle X-ray scattering as a probe for insulin denaturation.
  Elshemey WM, Mohammad IA, Elsayed AA
  Int J Biol Macromol. 2010
  PubMed ID: 20361993
   
  
• Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression.
  Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R
  J Virol. 2010
  PubMed ID: 20357092
   
  
• Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
  Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM
  J Cell Biol. 2010
  PubMed ID: 20440000
   
  
• Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.
  Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G
  J Clin Invest. 2010
  PubMed ID: 20364088
   
  
• Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
  Comellas AP, Kelly AM, Trejo HE, Briva A, Lee J, Sznajder JI, Dada LA
  J Cell Sci. 2010
  PubMed ID: 20332111
   
  
• X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
  Timofeev VI, Chuprov-Netochin RN, Samigina VR, Bezuglov VV, Miroshnikov KA, Kuranova IP
  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010
  PubMed ID: 20208155
   
  
• Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice.
  Gurley SB, Mach CL, Stegbauer J, Yang J, Snow KP, Hu A, Meyer TW, Coffman TM
  Am J Physiol Renal Physiol. 2010
  PubMed ID: 20042456
   
  
• Hyperglycemia impairs proteasome function by methylglyoxal.
  Queisser MA, Yao D, Geisler S, Hammes HP, Lochnit G, Schleicher ED, Brownlee M, Preissner KT
  Diabetes. 2010
  PubMed ID: 20009088
   
  
• Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus.
  Yilmaz O, Kucuk M, Ilgin A, Dagdelen M
  J Diabetes Complications. 2010
  PubMed ID: 19269197
   
  
• Lability landscape and protease resistance of human insulin amyloid: a new insight into its molecular properties.
  Malisauskas M, Weise C, Yanamandra K, Wolf-Watz M, Morozova-Roche L
  J Mol Biol. 2010
  PubMed ID: 19913026
   
  
• Implications for the active form of human insulin based on the structural convergence of highly active hormone analogues.
  Jirácek J, Záková L, Antolíková E, Watson CJ, Turkenburg JP, Dodson GG, Brzozowski AM
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20133841
   
  
• Effect of PCI on inflammatory markers, adiponectin and insulin resistance.
  Gomes ME, Smits P, Verheugt FW, Tack CJ
  EuroIntervention. 2010
  PubMed ID: 20142200
   
  
• Human recombinant ACE2 reduces the progression of diabetic nephropathy.
  Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW
  Diabetes. 2010
  PubMed ID: 19934006
   
  
• Associations of free fatty acids with insulin secretion and action among African-American and European-American girls and women.
  Goree LL, Darnell BE, Oster RA, Brown MA, Gower BA
  Obesity (Silver Spring). 2010
  PubMed ID: 19680231
   
  
• Relationship of Insulin-Like Growth Factors System Gene Polymorphisms with the Susceptibility and Pathological Development of Hepatocellular Carcinoma.
  Weng CJ, Hsieh YH, Tsai CM, Chu YH, Ueng KC, Liu YF, Yeh YH, Su SC, Chen YC, Chen MK, Yang SF
  Ann Surg Oncol. 2010
  PubMed ID: 20119675
   
  
• Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted.
  Park SY, Ye H, Steiner DF, Bell GI
  Biochem Biophys Res Commun. 2010
  PubMed ID: 20034470
   
  
• Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice.
  Wang Q, Frolova AI, Purcell S, Adastra K, Schoeller E, Chi MM, Schedl T, Moley KH
  PLoS One. 2010
  PubMed ID: 21209947
   
  
• The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach.
  Di Camillo B, Sanavia T, Iori E, Bronte V, Roncaglia E, Maran A, Avogaro A, Toffolo G, Cobelli C
  PLoS One. 2010
  PubMed ID: 21203503
   
  
• Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects.
  van Dijk SJ, Feskens EJ, Heidema AG, Bos MB, van de Rest O, Geleijnse JM, de Groot LC, Müller M, Afman LA
  PLoS One. 2010
  PubMed ID: 21203453
   
  
• Validation of structural and functional lesions of diabetic retinopathy in mice.
  Kern TS, Tang J, Berkowitz BA
  Mol Vis. 2010
  PubMed ID: 21139688
   
  
• Palmitate and insulin synergistically induce IL-6 expression in human monocytes.
  Bunn RC, Cockrell GE, Ou Y, Thrailkill KM, Lumpkin CK, Fowlkes JL
  Cardiovasc Diabetol. 2010
  PubMed ID: 21054880
   
  
• Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements.
  Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF
  PLoS Biol. 2010
  PubMed ID: 20808760
   
  
• Insulin VNTR and IGF-1 promoter region polymorphisms are not associated with body composition in early childhood: the generation R study.
  Maas JA, Mook-Kanamori DO, Ay L, Steegers EA, van Duijn CM, Hofman A, Hokken-Koelega AC, Jaddoe VW
  Horm Res Paediatr. 2010
  PubMed ID: 20190549
   
  
• Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain.
  Parrella E, Longo VD
  ScientificWorldJournal. 2010
  PubMed ID: 20098959
   
  
• Rapid reversal of insulin-stimulated AS160 phosphorylation in rat skeletal muscle after insulin exposure.
  Sharma N, Arias EB, Cartee GD
  Physiol Res. 2010
  PubMed ID: 19249902
   
  
• The level of fasting serum insulin, but not adiponectin, is associated with the prognosis of early stage hepatocellular carcinoma.
  Miuma S, Ichikawa T, Taura N, Shibata H, Takeshita S, Akiyama M, Motoyoshi Y, Ozawa E, Fujimoto M, Kawashimo H, Miyaaki H, Eguchi K, Nakao K
  Oncol Rep. 2009
  PubMed ID: 19885595
   
  
• An imprinted GFP insertion reveals long-range epigenetic regulation in embryonic lineages.
  Jones MJ, Lefebvre L
  Dev Biol. 2009
  PubMed ID: 19778534
   
  
• A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.
  Cheng L, Han X, Shi Y
  Am J Physiol Endocrinol Metab. 2009
  PubMed ID: 19773578
   
  
• Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer.
  Mattarocci S, Abbruzzese C, Mileo AM, Visca P, Antoniani B, Alessandrini G, Facciolo F, Felsani A, Radulescu RT, Paggi MG
  J Cell Physiol. 2009
  PubMed ID: 19688775
   
  
• Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women.
  Kontorovich T, Levy A, Korostishevsky M, Nir U, Friedman E
  Int J Cancer. 2009
  PubMed ID: 19950226
   
  
• The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
  Lefebvre L, Mar L, Bogutz A, Oh-McGinnis R, Mandegar MA, Paderova J, Gertsenstein M, Squire JA, Nagy A
  Hum Mol Genet. 2009
  PubMed ID: 19684026
   
  
• Cdc42-mediated tubulogenesis controls cell specification.
  Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H
  Cell. 2009
  PubMed ID: 19914171
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity.
  Romacho T, Azcutia V, Vázquez-Bella M, Matesanz N, Cercas E, Nevado J, Carraro R, Rodríguez-Mañas L, Sánchez-Ferrer CF, Peiró C
  Diabetologia. 2009
  PubMed ID: 19727662
   
  
• Cell and molecular mechanisms of insulin-induced angiogenesis.
  Liu Y, Petreaca M, Martins-Green M
  J Cell Mol Med. 2009
  PubMed ID: 19602055
   
  
• Forskolin attenuates the action of insulin on the Akt-mTOR pathway in human skeletal muscle.
  Richmond SR, Touchberry CD, Gallagher PM
  Appl Physiol Nutr Metab. 2009
  PubMed ID: 19935854
   
  
• Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
  Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF
  Nat Genet. 2009
  PubMed ID: 19767753
   
  
• Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris.
  Melnik BC, Schmitz G
  Exp Dermatol. 2009
  PubMed ID: 19709092
   
  
• The influence of glucose-lowering therapies on cancer risk in type 2 diabetes.
  Currie CJ, Poole CD, Gale EA
  Diabetologia. 2009
  PubMed ID: 19572116
   
  
• Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women.
  Brennan IM, Feltrin KL, Nair NS, Hausken T, Little TJ, Gentilcore D, Wishart JM, Jones KL, Horowitz M, Feinle-Bisset C
  Am J Physiol Gastrointest Liver Physiol. 2009
  PubMed ID: 19556358
   
  
• Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis.
  Kwon H, Jeong K, Pak Y
  J Cell Mol Med. 2009
  PubMed ID: 19778377
   
  
• Obesity potentiates the growth and dissemination of pancreatic cancer.
  Zyromski NJ, Mathur A, Pitt HA, Wade TE, Wang S, Nakshatri P, Swartz-Basile DA, Nakshatri H
  Surgery. 2009
  PubMed ID: 19628082
   
  
• Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
  Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y
  Int J Mol Med. 2009
  PubMed ID: 19578796
   
  
• Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus.
  Kolb A, Rieder S, Born D, Giese NA, Giese T, Rudofsky G, Werner J, Büchler MW, Friess H, Esposito I, Kleeff J
  Cancer Biol Ther. 2009
  PubMed ID: 19571666
   
  
• Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.
  Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH
  Mech Dev. 2009
  PubMed ID: 19501159
   
  
• Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.
  Chen HH, Lee WJ, Fann CS, Bouchard C, Pan WH
  Am J Clin Nutr. 2009
  PubMed ID: 19491387
   
  
• Antidiabetic therapies affect risk of pancreatic cancer.
  Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL
  Gastroenterology. 2009
  PubMed ID: 19375425
   
  
• Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion.
  Iacobazzi V, Infantino V, Bisaccia F, Castegna A, Palmieri F
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19445897
   
  
• Dealing with employment issues.
  TDIC Risk Management Staff
  Hawaii Dent J. 2009
  PubMed ID: 20043456
   
  
• Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells.
  Pandey AK, Bhardwaj V, Datta M
  FEBS J. 2009
  PubMed ID: 19769745
   
  
• Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
  Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM
  Dev Cell. 2009
  PubMed ID: 19619492
   
  
• Leptin, insulin, and obesity-related phenotypes: genetic influences on levels and longitudinal changes.
  Friedlander Y, Meiner V, Sharon N, Siscovick DS, Miserez AR
  Obesity (Silver Spring). 2009
  PubMed ID: 19214176
   
  
• Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.
  Chai B, Li JY, Zhang W, Wang H, Mulholland MW
  Peptides. 2009
  PubMed ID: 19463742
   
  
• Direct experimental evidence for quadruplex-quadruplex interaction within the human ILPR.
  Schonhoft JD, Bajracharya R, Dhakal S, Yu Z, Mao H, Basu S
  Nucleic Acids Res. 2009
  PubMed ID: 19324891
   
  
• Regulated renin release from 3T3-L1 adipocytes.
  Fowler JD, Johnson ND, Haroldson TA, Brintnall JA, Herrera JE, Katz SA, Bernlohr DA
  Am J Physiol Endocrinol Metab. 2009
  PubMed ID: 19293336
   
  
• Association between the 4 bp proinsulin gene insertion polymorphism (IVS-69) and body composition in black South African women.
  Berman P, Collins M, Baumgarten I, Seoighe C, Jennings CL, Joffe Y, Lambert EV, Levitt NS, Faulenbach MV, Kahn SE, Goedecke JH
  Obesity (Silver Spring). 2009
  PubMed ID: 19247282
   
  
• Molecular basis of catalytic chamber-assisted unfolding and cleavage of human insulin by human insulin-degrading enzyme.
  Manolopoulou M, Guo Q, Malito E, Schilling AB, Tang WJ
  J Biol Chem. 2009
  PubMed ID: 19321446
   
  
• Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth.
  Petry CJ, Rayco-Solon P, Fulford AJ, Stead JD, Wingate DL, Ong KK, Sirugo G, Prentice AM, Dunger DB
  Hum Genet. 2009
  PubMed ID: 19434426
   
  
• Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy.
  Li J, Wang JJ, Yu Q, Wang M, Zhang SX
  FEBS Lett. 2009
  PubMed ID: 19364508
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Glycemic exposure is affected favorably by inhaled human insulin (Exubera) as compared with subcutaneous insulin glargine (Lantus) in patients with type 2 diabetes.
  Hompesch M, Kollmeier A, Rave K, Heinemann L, Mitnick M, Davies S, Strack T
  Diabetes Technol Ther. 2009
  PubMed ID: 19537357
   
  
• Insulin stimulates hepatic low density lipoprotein receptor-related protein 1 (LRP1) to increase postprandial lipoprotein clearance.
  Laatsch A, Merkel M, Talmud PJ, Grewal T, Beisiegel U, Heeren J
  Atherosclerosis. 2009
  PubMed ID: 18834984
   
  
• Human longevity and 11p15.5: a study in 1321 centenarians.
  Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C
  Eur J Hum Genet. 2009
  PubMed ID: 19367319
   
  
• MFng is dispensable for mouse pancreas development and function.
  Svensson P, Bergqvist I, Norlin S, Edlund H
  Mol Cell Biol. 2009
  PubMed ID: 19223466
   
  
• Neuritic dystrophy and neuronopathy in Akita (Ins2(Akita)) diabetic mouse sympathetic ganglia.
  Schmidt RE, Green KG, Snipes LL, Feng D
  Exp Neurol. 2009
  PubMed ID: 19111542
   
  
• Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers.
  De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19188609
   
  
• Prolonged exposure to high insulin impairs the endothelial PI3-kinase/Akt/nitric oxide signalling.
  Madonna R, De Caterina R
  Thromb Haemost. 2009
  PubMed ID: 19190820
   
  
• Insulin enhances proliferation and viability of human umbilical vein endothelial cells.
  Shrader CD, Bailey KM, Konat GW, Cilento EV, Reilly FD
  Arch Dermatol Res. 2009
  PubMed ID: 19115062
   
  
• Effects of exercise on energy-regulating hormones and appetite in men and women.
  Hagobian TA, Sharoff CG, Stephens BR, Wade GN, Silva JE, Chipkin SR, Braun B
  Am J Physiol Regul Integr Comp Physiol. 2009
  PubMed ID: 19073905
   
  
• Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
  Lee JH, Palaia T, Ragolia L
  Am J Physiol Cell Physiol. 2009
  PubMed ID: 19052261
   
  
• Analysis of the relationship of leptin, high-sensitivity C-reactive protein, adiponectin, insulin, and uric acid to metabolic syndrome in lean, overweight, and obese young females.
  Abdullah AR, Hasan HA, Raigangar VL
  Metab Syndr Relat Disord. 2009
  PubMed ID: 19025443
   
  
• Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
  Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
  Clin Chim Acta. 2009
  PubMed ID: 18996102
   
  
• Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.
  Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ
  Nature. 2009
  PubMed ID: 19092805
   
  
• No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population.
  Xu Y, Wei Z, Zhang Z, Xing Q, Hu P, Zhang X, Gao G, Wang Y, Gao Q, Yi L, Cao Y
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19948072
   
  
• ANP and insulin presence in human foetal pancreas.
  Valentino B, Lipari D, Peri G, Lipari L, Valentino A, Farina E
  Ital J Anat Embryol. 2009
  PubMed ID: 19845278
   
  
• Relationship between bone mineral density, leptin and insulin concentration in Brazilian obese adolescents.
  do Prado WL, de Piano A, Lazaretti-Castro M, de Mello MT, Stella SG, Tufik S, do Nascimento CM, Oyama LM, Lofrano MC, Tock L, Caranti DA, Dâmaso AR
  J Bone Miner Metab. 2009
  PubMed ID: 19466592
   
  
• Polymorphism -23HPhI in the promoter of insulin gene and pancreatic cancer: A pilot study.
  T K, M J, M P, M V, M Z, Z K, T S, A Z
  Neoplasma. 2009
  PubMed ID: 19152242
   
  
• Dicer is required for maintaining adult pancreas.
  Morita S, Hara A, Kojima I, Horii T, Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I
  PLoS ONE. 2009
  PubMed ID: 19148298
   
  
• Insulin inhibits tissue factor expression in monocytes.
  Gerrits AJ, Koekman CA, Yildirim C, Nieuwland R, Akkerman JW
  J Thromb Haemost. 2009
  PubMed ID: 18983503
   
  
• Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
  Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 19064572
   
  
• Directed overexpression of insulin in Leydig cells causes a progressive loss of germ cells.
  Shirneshan K, Binder S, Böhm D, Wolf S, Sancken U, Meinhardt A, Schmid M, Engel W, Adham IM
  Mol Cell Endocrinol. 2008
  PubMed ID: 18692115
   
  
• Genotype score in addition to common risk factors for prediction of type 2 diabetes.
  Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D'Agostino RB, Cupples LA
  N Engl J Med. 2008
  PubMed ID: 19020323
   
  
• Insulin gene polymorphism in women with polycystic ovary syndrome.
  Ferk P, Perme MP, Gersak K
  J Int Med Res. 2008
  PubMed ID: 19094425
   
  
• Safety and efficacy of inhaled human insulin (Exubera) during discontinuation and readministration of therapy in adults with type 1 diabetes: A 3-year randomized controlled trial.
  Skyler JS, Hollander PA, Jovanovic L, Klioze S, Krasner A, Riese RJ, Reis J, Schwartz P, Duggan W, Inhaled Human Insulin Type 1 Diabetes Study Group
  Diabetes Res Clin Pract. 2008
  PubMed ID: 18824271
   
  
• Independent influence of insulin, catecholamines, and thyroid hormones on metabolic syndrome.
  De Pergola G, Giorgino F, Benigno R, Guida P, Giorgino R
  Obesity (Silver Spring). 2008
  PubMed ID: 18719673
   
  
• Circadian oscillation of circulating prothrombotic thrombospondin-1: ex vivo and in vivo regulation by insulin.
  Tan BK, Syed F, Lewandowski KC, O'Hare JP, Randeva HS
  J Thromb Haemost. 2008
  PubMed ID: 18853485
   
  
• Insulin potentiates cytokine-induced VCAM-1 expression in human endothelial cells.
  Madonna R, Massaro M, De Caterina R
  Biochim Biophys Acta. 2008
  PubMed ID: 18582564
   
  
• Pericyte migration: a novel mechanism of pericyte loss in experimental diabetic retinopathy.
  Pfister F, Feng Y, vom Hagen F, Hoffmann S, Molema G, Hillebrands JL, Shani M, Deutsch U, Hammes HP
  Diabetes. 2008
  PubMed ID: 18559662
   
  
• In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.
  Smith SB, Duplantier J, Dun Y, Mysona B, Roon P, Martin PM, Ganapathy V
  Invest Ophthalmol Vis Sci. 2008
  PubMed ID: 18469181
   
  
• Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms.
  Liu GP, Zhang Y, Yao XQ, Zhang CE, Fang J, Wang Q, Wang JZ
  Neurobiol Aging. 2008
  PubMed ID: 17433504
   
  
• Analysis of the Association of Preeclampsia with Polymorphisms of the INS, INSR and IRS1 Genes in Mexican Women.
  Machorro-Lazo MV, Sanchez-Corona J, Martínez-Abundis E, González-Ortiz M, Galaviz-Hernandez C, Perea FJ, Garcia-Zapien AG, Cruz-Quevedo EG, Salgado-Goytia L, Moran-Moguel MC, Flores-Martínez SE
  Gynecol Obstet Invest. 2008
  PubMed ID: 18716398
   
  
• Polymorphism of human leptin receptor gene is associated with type 2 diabetic patients complicated with non-alcoholic fatty liver disease in China.
  Lu H, Sun J, Sun L, Shu X, Xu Y, Xie D
  J Gastroenterol Hepatol. 2008
  PubMed ID: 18713300
   
  
• Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
  Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
  J Lipid Res. 2008
  PubMed ID: 18660489
   
  
• Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.
  Yoshida T, Shiraki N, Baba H, Goto M, Fujiwara S, Kume K, Kume S
  Genes Cells. 2008
  PubMed ID: 18498355
   
  
• Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.
  Hirosawa M, Minata M, Harada KH, Hitomi T, Krust A, Koizumi A
  Biochem Biophys Res Commun. 2008
  PubMed ID: 18439911
   
  
• Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.
  Sutherland G, Mellick G, Newman J, Double KL, Stevens J, Lee L, Rowe D, Silburn P, Halliday GM
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 18085551
   
  
• Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells.
  Berensztein EB, Baquedano MS, Pepe CM, Costanzo M, Saraco NI, Ponzio R, Rivarola MA, Belgorosky A
  Pediatr Res. 2008
  PubMed ID: 18520331
   
  
• INS VNTR Is Not Associated With Childhood Obesity in 1,023 Families: A Family-based Study.
  Bouatia-Naji N, De Graeve F, Brönner G, Lecoeur C, Vatin V, Durand E, Lichtner P, Nguyen TT, Heude B, Weill J, Lévy-Marchal C, Hebebrand J, Froguel P, Meyre D
  Obesity (Silver Spring). 2008
  PubMed ID: 18388898
   
  
• IRS1-independent defects define major nodes of insulin resistance.
  Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y, James DE
  Cell Metab. 2008
  PubMed ID: 18460333
   
  
• The role of osteopontin in the development of albuminuria.
  Lorenzen J, Shah R, Biser A, Staicu SA, Niranjan T, Garcia AM, Gruenwald A, Thomas DB, Shatat IF, Supe K, Woroniecki RP, Susztak K
  J Am Soc Nephrol. 2008
  PubMed ID: 18443355
   
  
• Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets.
  Rauchfuss S, Geiger J, Walter U, Renne T, Gambaryan S
  J Thromb Haemost. 2008
  PubMed ID: 18284601
   
  
• Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans.
  Thrush AB, Heigenhauser GJ, Mullen KL, Wright DC, Dyck DJ
  Am J Physiol Regul Integr Comp Physiol. 2008
  PubMed ID: 18305020
   
  
• Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury.
  Faulhaber-Walter R, Chen L, Oppermann M, Kim SM, Huang Y, Hiramatsu N, Mizel D, Kajiyama H, Zerfas P, Briggs JP, Kopp JB, Schnermann J
  J Am Soc Nephrol. 2008
  PubMed ID: 18256360
   
  
• Polymorphism of genes related to insulin sensitivity and the risk of biliary tract cancer and biliary stone: a population-based case-control study in Shanghai, China.
  Chang SC, Rashid A, Gao YT, Andreotti G, Shen MC, Wang BS, Han TQ, Zhang BH, Sakoda LC, Leitzmann MF, Chen BE, Rosenberg P, Chen J, Chanock S, Hsing AW
  Carcinogenesis. 2008
  PubMed ID: 18375961
   
  
• Insulin acutely upregulates protein expression of the fatty acid transporter CD36 in human skeletal muscle in vivo.
  Corpeleijn E, Pelsers MM, Soenen S, Mensink M, Bouwman FG, Kooi ME, Saris WH, Glatz JF, Blaak EE
  J Physiol Pharmacol. 2008
  PubMed ID: 18441389
   
  
• Adaptive evolution of the insulin two-gene system in mouse.
  Shiao MS, Liao BY, Long M, Yu HT
  Genetics. 2008
  PubMed ID: 18245324
   
  
• Increased skeletal muscle tumor necrosis factor-alpha and impaired insulin signaling persist in obese women with gestational diabetes mellitus 1 year postpartum.
  Friedman JE, Kirwan JP, Jing M, Presley L, Catalano PM
  Diabetes. 2008
  PubMed ID: 18083784
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin.
  Sreekanth R, Pattabhi V, Rajan SS
  Biochimie. 2008
  PubMed ID: 18029081
   
  
• Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women.
  de Jongh RT, Serné EH, IJzerman RG, Jørstad HT, Stehouwer CD
  Microvasc Res. 2008
  PubMed ID: 17920639
   
  
• Ghrelin - growth hormone releasing and orexigenic hormone in men declines with age, insulin and with decrease in testosterone concentration.
  Kozakowski J, Rabijewski M, Zgliczyński W
  Neuro Endocrinol Lett. 2008
  PubMed ID: 18283260
   
  
• Is there any relation between hyperinsulinemia, insulin resistance and colorectal lesions in patients with acromegaly?
  Foltyn W, Kos-Kudla B, Strzelczyk J, Matyja V, Karpe J, Rudnik A, Marek B, Kajdaniuk D, Sieron A, Latos W
  Neuro Endocrinol Lett. 2008
  PubMed ID: 18283256
   
  
• Serum insulin levels and the degree of thyroid dysfunction in hypothyroid women.
  Owecki M, El Ali Z, Nikisch E, Sowiński J
  Neuro Endocrinol Lett. 2008
  PubMed ID: 18283245
   
  
• C-peptide constricts pancreatic islet arterioles in diabetic, but not normoglycaemic mice.
  Nordquist L, Lai EY, Sjöquist M, Jansson L, Persson AE
  Diabetes Metab Res Rev. 2008
  PubMed ID: 18157793
   
  
• Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
  Aigner B, Rathkolb B, Herbach N, Hrabé de Angelis M, Wanke R, Wolf E
  Am J Physiol Endocrinol Metab. 2008
  PubMed ID: 18056790
   
  
• Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.
  Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, Squire JA, Higgins MJ, Nagy A, Lefebvre L
  Mol Cell Biol. 2008
  PubMed ID: 18039841
   
  
• Association between small for gestational age and paternally inherited 5' insulin haplotypes.
  Adkins RM, Krushkal J, Klauser CK, Magann EF, Morrison JC, Somes G
  Int J Obes (Lond). 2008
  PubMed ID: 17700581
   
  
• Process and purification for manufacture of a modified insulin intended for oral delivery.
  Dave N, Hazra P, Khedkar A, Manjunath HS, Iyer H, Suryanarayanan S
  J Chromatogr A. 2008
  PubMed ID: 17675047
   
  
• Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.
  Lynn FC, Sanchez L, Gomis R, German MS, Gasa R
  PLoS ONE. 2008
  PubMed ID: 18560595
   
  
• Leptin, insulin, and glucose serum levels in large-for-gestational-age infants of diabetic and non-diabetic mothers.
  Vela-Huerta MM, San Vicente-Santoscoy EU, Guizar-Mendoza JM, Amador-Licona N, Aldana-Valenzuela C, Hernnández J
  J Pediatr Endocrinol Metab. 2008
  PubMed ID: 18404969
   
  
• Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?
  Li C, Ford ES, Meng YX, Mokdad AH, Reaven GM
  Cardiovasc Diabetol. 2008
  PubMed ID: 18307789
   
  
• FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia.
  Nyeng P, Norgaard GA, Kobberup S, Jensen J
  BMC Dev Biol. 2008
  PubMed ID: 18186922
   
  
• Structure of human insulin monomer in water/acetonitrile solution.
  Bocian W, Sitkowski J, Bednarek E, Tarnowska A, Kawecki R, Kozerski L
  J Biomol NMR. 2008
  PubMed ID: 18040865
   
  
• Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells.
  Sun J, Jin T
  Cell Signal. 2008
  PubMed ID: 17993259
   
  
• Modulation of Aire regulates the expression of tissue-restricted antigens.
  Kont V, Laan M, Kisand K, Merits A, Scott HS, Peterson P
  Mol Immunol. 2008
  PubMed ID: 17599412
   
  
• Insulin-inhibited and stimulated cultured vascular smooth muscle cell migration are related to divergent effects on protein phosphatase-2A and autonomous calcium/calmodulin-dependent protein kinase II.
  Yang M, Kahn AM
  Atherosclerosis. 2008
  PubMed ID: 17553505
   
  
• Smoking, fasting serum insulin, and obesity are the predictors of carotid atherosclerosis in relatively young subjects.
  Naya T, Hosomi N, Ohyama H, Ichihara S, Ban CR, Takahashi T, Taminato T, Feng A, Kohno M, Koziol JA
  Angiology. 2007
  PubMed ID: 18216377
   
  
• Improved insulin sensitivity and adiponectin level after exercise training in obese Korean youth.
  Kim ES, Im JA, Kim KC, Park JH, Suh SH, Kang ES, Kim SH, Jekal Y, Lee CW, Yoon YJ, Lee HC, Jeon JY
  Obesity (Silver Spring). 2007
  PubMed ID: 18198311
   
  
• Influence of BMI and gender on postprandial hormone responses.
  Carroll JF, Kaiser KA, Franks SF, Deere C, Caffrey JL
  Obesity (Silver Spring). 2007
  PubMed ID: 18198306
   
  
• Regulation and function of the Rhox5 homeobox gene.
  Hu Z, MacLean JA, Bhardwaj A, Wilkinson MF
  Ann N Y Acad Sci. 2007
  PubMed ID: 18184911
   
  
• Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study.
  Mook-Kanamori DO, Miranda Geelhoed JJ, Steegers EA, Witteman JC, Hofman A, Moll HA, van Duijn CM, Hokken-Koelega AC, Jaddoe VW
  Eur J Endocrinol. 2007
  PubMed ID: 18057381
   
  
• Milk intake and feeding behavior in the first week of life and its relationship to cord blood ghrelin, leptin, and insulin concentrations.
  James RJ, James A, Drewett RF, Cheetham TD
  Pediatr Res. 2007
  PubMed ID: 17957153
   
  
• Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses.
  Jensen M, Hansen B, De Meyts P, Schäffer L, Ursø B
  J Biol Chem. 2007
  PubMed ID: 17925406
   
  
• Lipid and insulin levels in obese children: changes with age and puberty.
  Pinhas-Hamiel O, Lerner-Geva L, Copperman NM, Jacobson MS
  Obesity (Silver Spring). 2007
  PubMed ID: 18070774
   
  
• Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure.
  Gastaldi G, Russell A, Golay A, Giacobino JP, Habicht F, Barthassat V, Muzzin P, Bobbioni-Harsch E
  Diabetologia. 2007
  PubMed ID: 17828388
   
  
• Lower insulin secretory response to glucose induced by artificial nutrition in children: prolonged and total parenteral nutrition.
  Beltrand J, Colomb V, Marinier E, Daubrosse C, Alison M, Burcelin R, Cani PD, Chevenne D, Marchal CL
  Pediatr Res. 2007
  PubMed ID: 17805200
   
  
• Insulin at physiological concentrations increases microvascular perfusion in human myocardium.
  Liu Z
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17698984
   
  
• Tuberculosis susceptibility of diabetic mice.
  Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H
  Am J Respir Cell Mol Biol. 2007
  PubMed ID: 17585110
   
  
• Transcriptional regulation of aquaporin 3 by insulin.
  Higuchi S, Kubota M, Iguchi K, Usui S, Kiho T, Hirano K
  J Cell Biochem. 2007
  PubMed ID: 17471492
   
  
• Lipoprotein particles, insulin, adiponectin, C-reactive protein and risk of coronary heart disease among men with metabolic syndrome.
  Kuller LH, Grandits G, Cohen JD, Neaton JD, Prineas R, Multiple Risk Factor Intervention Trial Research Group
  Atherosclerosis. 2007
  PubMed ID: 17011566
   
  
• Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.
  Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA
  Development. 2007
  PubMed ID: 17855428
   
  
• Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.
  Adkins RM, Fain JN, Krushkal J, Klauser CK, Magann EF, Morrison JC
  Pediatr Res. 2007
  PubMed ID: 17667841
   
  
• The association of fasting insulin concentrations and colonic neoplasms in acromegaly: a colonoscopy-based study in 210 patients.
  Colao A, Pivonello R, Auriemma RS, Galdiero M, Ferone D, Minuto F, Marzullo P, Lombardi G
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17652220
   
  
• Role of c-Abl in directing metabolic versus mitogenic effects in insulin receptor signaling.
  Frasca F, Pandini G, Malaguarnera R, Mandarino A, Messina RL, Sciacca L, Belfiore A, Vigneri R
  J Biol Chem. 2007
  PubMed ID: 17620332
   
  
• Insulin & C-peptide levels in sulfonylurea-induced hypoglycemia: a systematic review.
  DeWitt CR, Heard K, Waksman JC
  J Med Toxicol. 2007
  PubMed ID: 18072146
   
  
• Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.
  Li ZQ, Yu WP, Xie XD, Li PQ, Guo TK, Zhang WH, An LZ, Wang XL
  Clin Exp Med. 2007
  PubMed ID: 17972051
   
  
• Insulin differentially modulates the peripheral endocannabinoid system in human subcutaneous abdominal adipose tissue from lean and obese individuals.
  Murdolo G, Kempf K, Hammarstedt A, Herder C, Smith U, Jansson PA
  J Endocrinol Invest. 2007
  PubMed ID: 17923791
   
  
• Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
  Pechlivanis S, Pardini B, Bermejo JL, Wagner K, Naccarati A, Vodickova L, Novotny J, Hemminki K, Vodicka P, Försti A
  Endocr Relat Cancer. 2007
  PubMed ID: 17914103
   
  
• Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels.
  Tworoger SS, Mantzoros C, Hankinson SE
  Obesity (Silver Spring). 2007
  PubMed ID: 17890489
   
  
• Recovery from diabetes in mice by beta cell regeneration.
  Nir T, Melton DA, Dor Y
  J Clin Invest. 2007
  PubMed ID: 17786244
   
  
• Effects of ghrelin administration on decreased growth hormone status in obese animals.
  Iwakura H, Akamizu T, Ariyasu H, Irako T, Hosoda K, Nakao K, Kangawa K
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17595213
   
  
• Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.
  Arcaro A, Doepfner KT, Boller D, Guerreiro AS, Shalaby T, Jackson SP, Schoenwaelder SM, Delattre O, Grotzer MA, Fischer B
  Biochem J. 2007
  PubMed ID: 17506723
   
  
• Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160.
  Frøsig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF
  Diabetes. 2007
  PubMed ID: 17513702
   
  
• Plasma leptin levels are related to body composition, sex, insulin levels and the A55V polymorphism of the UCP2 gene.
  Rance KA, Johnstone AM, Murison S, Duncan JS, Wood SG, Speakman JR
  Int J Obes (Lond). 2007
  PubMed ID: 17342078
   
  
• Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG
  Nat Genet. 2007
  PubMed ID: 17554260
   
  
• Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome.
  Sir-Petermann T, Echiburú B, Maliqueo MM, Crisosto N, Sánchez F, Hitschfeld C, Cárcamo M, Amigo P, Pérez-Bravo F
  Hum Reprod. 2007
  PubMed ID: 17468256
   
  
• The C-peptide fragment EVARQ reduces glomerular hyperfiltration in streptozotocin-induced diabetic rats.
  Nordquist L, Moe E, Sjöquist M
  Diabetes Metab Res Rev. 2007
  PubMed ID: 17103462
   
  
• Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice.
  Thomaseth K, Pavan A, Pacini G, Ahrén B
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17311896
   
  
• Basal and insulin-regulated free fatty acid and glucose metabolism in humans.
  Shadid S, Kanaley JA, Sheehan MT, Jensen MD
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17299081
   
  
• Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.
  Vanhorenbeeck V, Jenny M, Cornut JF, Gradwohl G, Lemaigre FP, Rousseau GG, Jacquemin P
  Dev Biol. 2007
  PubMed ID: 17400205
   
  
• Genetic variations within the insulin gene region are associated with accelerated fetal growth.
  Osada H, Seki K, Sekiya S
  Tohoku J Exp Med. 2007
  PubMed ID: 17464100
   
  
• Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein.
  Grünblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S
  J Neurochem. 2007
  PubMed ID: 17448147
   
  
• Increased apoptosis of parasympathetic but not enteric neurons in mice lacking GFRalpha2.
  Lähteenmäki M, Kupari J, Airaksinen MS
  Dev Biol. 2007
  PubMed ID: 17355878
   
  
• Alteration of glucose homeostasis in V1a vasopressin receptor-deficient mice.
  Aoyagi T, Birumachi J, Hiroyama M, Fujiwara Y, Sanbe A, Yamauchi J, Tanoue A
  Endocrinology. 2007
  PubMed ID: 17303660
   
  
• Insulin resistance-related genes and advanced left-sided colorectal adenoma.
  Gunter MJ, Hayes RB, Chatterjee N, Yeager M, Welch R, Schoen RE, Yakochi L, Schatzkin A, Peters U
  Cancer Epidemiol Biomarkers Prev. 2007
  PubMed ID: 17416760
   
  
• Regulation of insulin receptor function.
  Youngren JF
  Cell Mol Life Sci. 2007
  PubMed ID: 17347799
   
  
• Ins2Akita mice exhibit hyperphagia and anxiety behavior via the melanocortin system.
  Asakawa A, Toyoshima M, Inoue K, Koizumi A
  Int J Mol Med. 2007
  PubMed ID: 17334640
   
  
• Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes.
  Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360472
   
  
• Altered postprandial glucose, insulin, leptin, and ghrelin in liver cirrhosis: correlations with energy intake and resting energy expenditure.
  Kalaitzakis E, Bosaeus I, Ohman L, Björnsson E
  Am J Clin Nutr. 2007
  PubMed ID: 17344504
   
  
• Adrenomedullin inhibits adipogenesis under transcriptional control of insulin.
  Harmancey R, Senard JM, Rouet P, Pathak A, Smih F
  Diabetes. 2007
  PubMed ID: 17327422
   
  
• Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells.
  Andreozzi F, Laratta E, Procopio C, Hribal ML, Sciacqua A, Perticone M, Miele C, Perticone F, Sesti G
  Mol Cell Biol. 2007
  PubMed ID: 17242212
   
  
• Kinetics of different processes in human insulin amyloid formation.
  Mauro M, Craparo EF, Podestà A, Bulone D, Carrotta R, Martorana V, Tiana G, San Biagio PL
  J Mol Biol. 2007
  PubMed ID: 17157312
   
  
• SOX9 is required for maintenance of the pancreatic progenitor cell pool.
  Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17267606
   
  
• Diabetes-induced alterations in renal medullary microcirculation and metabolism.
  Nordquist L, Palm F
  Curr Diabetes Rev. 2007
  PubMed ID: 18220656
   
  
• Cellular internalization of proinsulin C-peptide.
  Lindahl E, Nyman U, Melles E, Sigmundsson K, Ståhlberg M, Wahren J, Obrink B, Shafqat J, Joseph B, Jörnvall H
  Cell Mol Life Sci. 2007
  PubMed ID: 17279313
   
  
• Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1.
  Harris TE, Huffman TA, Chi A, Shabanowitz J, Hunt DF, Kumar A, Lawrence JC
  J Biol Chem. 2007
  PubMed ID: 17105729
   
  
• Crystallographic characterization of two novel crystal forms of human insulin induced by chaotropic agents and a shift in pH.
  Norrman M, Schluckebier G
  BMC Struct Biol. 2007
  PubMed ID: 18093308
   
  
• VNTR I/I genotype of insulin gene is associated with the increase of follicle number independent from polycystic ovary syndrome.
  Haller K, Laisk T, Peters M, Talving E, Karits P, Karro H, Uibo R, Salumets A
  Acta Obstet Gynecol Scand. 2007
  PubMed ID: 17520407
   
  
• Insulin-like growth factor (IGF)-I and insulin in normal and growth-restricted mother/infant pairs.
  Malamitsi-Puchner A, Briana DD, Gourgiotis D, Boutsikou M, Puchner KP, Baka S, Marmarinos A, Hassiakos D
  Mediators Inflamm. 2007
  PubMed ID: 17497031
   
  
• Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer.
  Wang Y, McCullough ML, Stevens VL, Rodriguez C, Jacobs EJ, Teras LR, Pavluck AL, Thun MJ, Calle EE
  Anticancer Res. 2007
  PubMed ID: 17348446
   
  
• Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study.
  North KE, Franceschini N, Borecki IB, Gu CC, Heiss G, Province MA, Arnett DK, Lewis CE, Miller MB, Myers RH, Hunt SC, Freedman BI
  Diabetes. 2007
  PubMed ID: 17192475
   
  
• A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
  Tchekneva EE, Rinchik EM, Polosukhina D, Davis LS, Kadkina V, Mohamed Y, Dunn SR, Sharma K, Qi Z, Fogo AB, Breyer MD
  J Am Soc Nephrol. 2007
  PubMed ID: 17151334
   
  
• Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls.
  Bilic E, Bilic E, Rudan I, Kusec V, Zurak N, Delimar D, Zagar M
  Eur J Neurol. 2006
  PubMed ID: 17116217
   
  
• C-Peptide induces vascular smooth muscle cell proliferation: involvement of SRC-kinase, phosphatidylinositol 3-kinase, and extracellular signal-regulated kinase 1/2.
  Walcher D, Babiak C, Poletek P, Rosenkranz S, Bach H, Betz S, Durst R, Grüb M, Hombach V, Strong J, Marx N
  Circ Res. 2006
  PubMed ID: 17068290
   
  
• Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice.
  Gyurko R, Siqueira CC, Caldon N, Gao L, Kantarci A, Van Dyke TE
  J Immunol. 2006
  PubMed ID: 17082643
   
  
• Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?
  Anthony K, Reed LJ, Dunn JT, Bingham E, Hopkins D, Marsden PK, Amiel SA
  Diabetes. 2006
  PubMed ID: 17065334
   
  
• Low cerebrospinal fluid insulin levels in obese humans.
  Kern W, Benedict C, Schultes B, Plohr F, Moser A, Born J, Fehm HL, Hallschmid M
  Diabetologia. 2006
  PubMed ID: 16951936
   
  
• Insulin gene variable number of tandem repeats (INS VNTR) genotype and metabolic syndrome in childhood obesity.
  Santoro N, Cirillo G, Amato A, Luongo C, Raimondo P, D'Aniello A, Perrone L, Miraglia del Giudice E
  J Clin Endocrinol Metab. 2006
  PubMed ID: 16868061
   
  
• Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3.
  Carnesecchi S, Carpentier JL, Foti M, Szanto I
  Exp Cell Res. 2006
  PubMed ID: 16949073
   
  
• Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.
  Li T, Kong X, Owsley E, Ellis E, Strom S, Chiang JY
  J Biol Chem. 2006
  PubMed ID: 16885156
   
  
• Diabetic modifier QTLs identified in F2 intercrosses between Akita and A/J mice.
  Takeshita S, Moritani M, Kunika K, Inoue H, Itakura M
  Mamm Genome. 2006
  PubMed ID: 16964447
   
  
• Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.
  Oyadomari S, Yun C, Fisher EA, Kreglinger N, Kreibich G, Oyadomari M, Harding HP, Goodman AG, Harant H, Garrison JL, Taunton J, Katze MG, Ron D
  Cell. 2006
  PubMed ID: 16923392
   
  
• Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
  Asayesh A, Sharpe J, Watson RP, Hecksher-Sørensen J, Hastie ND, Hill RE, Ahlgren U
  Genes Dev. 2006
  PubMed ID: 16912273
   
  
• Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability.
  Nakagawa SH, Hua QX, Hu SQ, Jia W, Wang S, Katsoyannis PG, Weiss MA
  J Biol Chem. 2006
  PubMed ID: 16751187
   
  
• Fibrillation of human insulin A and B chains.
  Hong DP, Ahmad A, Fink AL
  Biochemistry. 2006
  PubMed ID: 16866381
   
  
• The normal phenotype of Pmm1-deficient mice suggests that Pmm1 is not essential for normal mouse development.
  Cromphout K, Vleugels W, Heykants L, Schollen E, Keldermans L, Sciot R, D'Hooge R, De Deyn PP, von Figura K, Hartmann D, Körner C, Matthijs G
  Mol Cell Biol. 2006
  PubMed ID: 16847318
   
  
• A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus.
  Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US
  Diabetologia. 2006
  PubMed ID: 16741735
   
  
• Loss of cholinergic and dopaminergic amacrine cells in streptozotocin-diabetic rat and Ins2Akita-diabetic mouse retinas.
  Gastinger MJ, Singh RS, Barber AJ
  Invest Ophthalmol Vis Sci. 2006
  PubMed ID: 16799061
   
  
• The insulin gene variable number of tandem repeat: associations and interactions with childhood body fat mass and insulin secretion in normal children.
  Heude B, Petry CJ, Avon Longitudinal Study of Parents Children (ALSPAC) study team, Pembrey M, Dunger DB, Ong KK
  J Clin Endocrinol Metab. 2006
  PubMed ID: 16608900
   
  
• Effect of intramuscular fat difference on glucose and insulin reaction in oral glucose tolerance test.
  Komiya H, Mori Y, Yokose T, Kurokawa N, Horie N, Tajima N
  J Atheroscler Thromb. 2006
  PubMed ID: 16835468
   
  
• Insulinemia and leptinemia in geriatric patients: markers of the metabolic syndrome or of undernutrition?
  Bonin-Guillaume S, Herrmann FR, Boillat D, Szanto I, Michel JP, Rohner-Jeanrenaud F, Vischer UM
  Diabetes Metab. 2006
  PubMed ID: 16799400
   
  
• The INS VNTR locus does not associate with smallness for gestational age (SGA) but interacts with SGA to increase insulin resistance in young adults.
  Vu-Hong TA, Durand E, Deghmoun S, Boutin P, Meyre D, Chevenne D, Czernichow P, Froguel P, Levy-Marchal C
  J Clin Endocrinol Metab. 2006
  PubMed ID: 16595598
   
  
• Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.
  Kilic G, Wang J, Sosa-Pineda B
  Dev Dyn. 2006
  PubMed ID: 16518820
   
  
• The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis.
  Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF
  Exp Cell Res. 2006
  PubMed ID: 16542650
   
  
• Stabilization of beta-catenin impacts pancreas growth.
  Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M
  Development. 2006
  PubMed ID: 16611688
   
  
• Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors.
  Kakoki M, Kizer CM, Yi X, Takahashi N, Kim HS, Bagnell CR, Edgell CJ, Maeda N, Jennette JC, Smithies O
  J Clin Invest. 2006
  PubMed ID: 16604193
   
  
• Insulin and leptin induce Glut4 plasma membrane translocation and glucose uptake in a human neuronal cell line by a phosphatidylinositol 3-kinase- dependent mechanism.
  Benomar Y, Naour N, Aubourg A, Bailleux V, Gertler A, Djiane J, Guerre-Millo M, Taouis M
  Endocrinology. 2006
  PubMed ID: 16497805
   
  
• Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.
  Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constância M, Moore GE
  Hum Mol Genet. 2006
  PubMed ID: 16531418
   
  
• Neuroprotection of insulin against oxidative stress-induced apoptosis in cultured retinal neurons: involvement of phosphoinositide 3-kinase/Akt signal pathway.
  Yu XR, Jia GR, Gao GD, Wang SH, Han Y, Cao W
  Acta Biochim Biophys Sin (Shanghai). 2006
  PubMed ID: 16604263
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Dlk1 expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placenta.
  Yevtodiyenko A, Schmidt JV
  Dev Dyn. 2006
  PubMed ID: 16456855
   
  
• Human chromosome 11 DNA sequence and analysis including novel gene identification.
  Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
  Nature. 2006
  PubMed ID: 16554811
   
  
• In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
  Briançon N, Weiss MC
  EMBO J. 2006
  PubMed ID: 16498401
   
  
• The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin.
  Dzwonek A, Mikula M, Ostrowski J
  FEBS Lett. 2006
  PubMed ID: 16519889
   
  
• Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells.
  Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED
  J Biol Chem. 2006
  PubMed ID: 16418171
   
  
• In vitro folding/unfolding of insulin/single-chain insulin.
  Qiao ZS, Guo ZY, Feng YM
  Protein Pept Lett. 2006
  PubMed ID: 16800793
   
  
• Glucagon secretion in relation to insulin sensitivity in healthy subjects.
  Ahrén B
  Diabetologia. 2006
  PubMed ID: 16362283
   
  
• Insulin control of placental gene expression shifts from mother to foetus over the course of pregnancy.
  Hiden U, Maier A, Bilban M, Ghaffari-Tabrizi N, Wadsack C, Lang I, Dohr G, Desoye G
  Diabetologia. 2006
  PubMed ID: 16344925
   
  
• A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys.
  Rodríguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, Miller GJ, Cooper CC, Cook DG, Whincup PH, Day IN
  Pharmacogenet Genomics. 2006
  PubMed ID: 16344718
   
  
• Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
  Rodríguez S, Gaunt TR, Dennison E, Chen XH, Syddall HE, Phillips DI, Cooper C, Day IN
  Eur J Hum Genet. 2006
  PubMed ID: 16251897
   
  
• Impact of genetic background on nephropathy in diabetic mice.
  Gurley SB, Clare SE, Snow KP, Hu A, Meyer TW, Coffman TM
  Am J Physiol Renal Physiol. 2006
  PubMed ID: 16118394
   
  
• Early events in the fibrillation of monomeric insulin.
  Ahmad A, Uversky VN, Hong D, Fink AL
  J Biol Chem. 2005
  PubMed ID: 16246845
   
  
• INSPstI polymorphism and prostate cancer in African-American men.
  Claeys GB, Sarma AV, Dunn RL, Zuhlke KA, Beebe-Dimmer J, Montie JE, Wojno KJ, Schottenfeld D, Cooney KA
  Prostate. 2005
  PubMed ID: 15880482
   
  
• The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse.
  Schechter R, Beju D, Miller KE
  Biochem Biophys Res Commun. 2005
  PubMed ID: 16039605
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• INS VNTR class genotype and indexes of body size and obesity: population-based studies of 7,999 middle-aged men and women.
  Sandhu MS, Heude B, Young EH, Luben R, Luan J, Khaw KT, Todd J, Wareham NJ
  Diabetes. 2005
  PubMed ID: 16123374
   
  
• Alms1-disrupted mice recapitulate human Alström syndrome.
  Collin GB, Cyr E, Bronson R, Marshall JD, Gifford EJ, Hicks W, Murray SA, Zheng QY, Smith RS, Nishina PM, Naggert JK
  Hum Mol Genet. 2005
  PubMed ID: 16000322
   
  
• Association of Kir6.2 and INS VNTR variants with glucose homeostasis in young obese.
  Le Fur S, Fradin D, Boileau P, Bougnères P
  Physiol Genomics. 2005
  PubMed ID: 15956217
   
  
• Prostate cancer risk and IRS1, IRS2, IGF1, and INS polymorphisms: strong association of IRS1 G972R variant and cancer risk.
  Neuhausen SL, Slattery ML, Garner CP, Ding YC, Hoffman M, Brothman AR
  Prostate. 2005
  PubMed ID: 15678496
   
  
• Interaction between insulin (VNTR) and hepatic lipase (LIPC-514C>T) variants on the response to an oral glucose tolerance test in the EARSII group of young healthy men.
  Waterworth DM, Jansen H, Nicaud V, Humphries SE, Talmud PJ, EARSII Study Group
  Biochim Biophys Acta. 2005
  PubMed ID: 15949705
   
  
• Insulin and IGF-1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells.
  Thompson AD, Kakar SS
  FEBS Lett. 2005
  PubMed ID: 15922332
   
  
• Influence of exogenous insulin on C-peptide levels in subjects with type 2 diabetes.
  Albareda M, Rigla M, Rodríguez-Espinosa J, Caballero A, Chico A, Cabezas R, Carreras G, Pérez A
  Diabetes Res Clin Pract. 2005
  PubMed ID: 15936461
   
  
• Insulin and leptin do not affect fatty acid uptake and metabolism in human placental choriocarcinoma (BeWo) cells.
  Duttaroy AK, Jørgensen A
  Prostaglandins Leukot Essent Fatty Acids. 2005
  PubMed ID: 15919610
   
  
• Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis.
  Chen Q, Yuan Y, Lin S, Chang Y, Zhuo X, Wei W, Tao P, Ruan L, Li Q, Li Z
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15823575
   
  
• Analysis of multiple data sets reveals no association between the insulin gene variable number tandem repeat element and polycystic ovary syndrome or related traits.
  Powell BL, Haddad L, Bennett A, Gharani N, Sovio U, Groves CJ, Rush K, Goh MJ, Conway GS, Ruokonen A, Martikainen H, Pouta A, Taponen S, Hartikainen AL, Halford S, Zeggini E, Järvelin MR, Franks S, McCarthy MI
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15705917
   
  
• Insulin and nitric oxide stimulates glucose transport in human placenta.
  Acevedo CG, Márquez JL, Rojas S, Bravo I
  Life Sci. 2005
  PubMed ID: 15792832
   
  
• Dependence of self-tolerance on TRAF6-directed development of thymic stroma.
  Akiyama T, Maeda S, Yamane S, Ogino K, Kasai M, Kajiura F, Matsumoto M, Inoue J
  Science. 2005
  PubMed ID: 15705807
   
  
• Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.
  Schattenberg JM, Wang Y, Singh R, Rigoli RM, Czaja MJ
  J Biol Chem. 2005
  PubMed ID: 15632182
   
  
• Dose-dependent insulin regulation of insulin-like growth factor binding protein-1 in human endometrial stromal cells is mediated by distinct signaling pathways.
  Lathi RB, Hess AP, Tulac S, Nayak NR, Conti M, Giudice LC
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15613433
   
  
• Insulin gene variable number of tandem repeats is associated with increased fat mass during adolescence in non-obese girls.
  Thorsby PM, Berg JP, Birkeland KI
  Scand J Clin Lab Invest. 2005
  PubMed ID: 16025839
   
  
• HIV-1 accessory protein Vpr inhibits the effect of insulin on the Foxo subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected pat
  Kino T, De Martino MU, Charmandari E, Ichijo T, Outas T, Chrousos GP
  Diabetes. 2005
  PubMed ID: 15616007
   
  
• Insulin inhibits platelet-derived growth factor-induced cell proliferation.
  Cirri P, Taddei ML, Chiarugi P, Buricchi F, Caselli A, Paoli P, Giannoni E, Camici G, Manao G, Raugei G, Ramponi G
  Mol Biol Cell. 2005
  PubMed ID: 15525682
   
  
• Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
  Wan Z, Xu B, Huang K, Chu YC, Li B, Nakagawa SH, Qu Y, Hu SQ, Katsoyannis PG, Weiss MA
  Biochemistry. 2004
  PubMed ID: 15610006
   
  
• IRIS II Study: Sensitivity and specificity of intact proinsulin, adiponectin, and the proinsulin/adiponectin ratio as markers for insulin resistance.
  Langenfeld MR, Forst T, Standl E, Strotmann HJ, Lübben G, Pahler S, Kann P, Pfützner A, IRIS II study
  Diabetes Technol Ther. 2004
  PubMed ID: 15684637
   
  
• Association of an insulin gene promoter insertion polymorphism with type 2 diabetes and diabetic nephropathy in African Americans.
  Karim MA, Wang X, Zhang Z, Bowden DW, Freedman BI, Elbein SC
  Mol Genet Metab. 2004
  PubMed ID: 15589123
   
  
• Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity.
  Melles E, Jörnvall H, Tryggvason S, Danielsson KG, Ekberg K, Tryggvason K, Wahren J, Bergman T
  Cell Mol Life Sci. 2004
  PubMed ID: 15583859
   
  
• Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice.
  Deltour L, Vandamme J, Jouvenot Y, Duvillié B, Kelemen K, Schaerly P, Jami J, Paldi A
  Gene Expr Patterns. 2004
  PubMed ID: 15567729
   
  
• Insulin decreases the secretion of apoB-100 from hepatic HepG2 cells but does not decrease the secretion of apoB-48 from intestinal CaCo-2 cells.
  Allister EM, Pal S, Thomson AM, Helmerhorst E, Mamo JC
  J Biomed Sci. 2004
  PubMed ID: 15591776
   
  
• Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus.
  Katsuki A, Urakawa H, Gabazza EC, Murashima S, Nakatani K, Togashi K, Yano Y, Adachi Y, Sumida Y
  Eur J Endocrinol. 2004
  PubMed ID: 15538935
   
  
• Development of hydrocephalus in mice lacking SOCS7.
  Krebs DL, Metcalf D, Merson TD, Voss AK, Thomas T, Zhang JG, Rakar S, O'bryan MK, Willson TA, Viney EM, Mielke LA, Nicola NA, Hilton DJ, Alexander WS
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15494444
   
  
• DNA polymorphism analysis of candidate genes for type 2 diabetes mellitus in a Mexican ethnic group.
  Flores-Martínez SE, Islas-Andrade S, Machorro-Lazo MV, Revilla MC, Juárez RE, Mújica-López KI, Morán-Moguel MC, López-Cardona MG, Sánchez-Corona J
  Ann Genet. 2004
  PubMed ID: 15581831
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance.
  Doronzo G, Russo I, Mattiello L, Anfossi G, Bosia A, Trovati M
  Eur J Clin Invest. 2004
  PubMed ID: 15473891
   
  
• Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy.
  Rochat A, Fernandez A, Vandromme M, Molès JP, Bouschet T, Carnac G, Lamb NJ
  Mol Biol Cell. 2004
  PubMed ID: 15282335
   
  
• Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor.
  Kakoki M, Takahashi N, Jennette JC, Smithies O
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15326315
   
  
• Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
  Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
  Genome Res. 2004
  PubMed ID: 15342556
   
  
• Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes.
  Kashyap SR, Belfort R, Berria R, Suraamornkul S, Pratipranawatr T, Finlayson J, Barrentine A, Bajaj M, Mandarino L, DeFronzo R, Cusi K
  Am J Physiol Endocrinol Metab. 2004
  PubMed ID: 15126243
   
  
• Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice.
  Cortes U, Tong WM, Coyle DL, Meyer-Ficca ML, Meyer RG, Petrilli V, Herceg Z, Jacobson EL, Jacobson MK, Wang ZQ
  Mol Cell Biol. 2004
  PubMed ID: 15282315
   
  
• Variation at the insulin gene VNTR (variable number tandem repeat) polymorphism and early growth: studies in a large Finnish birth cohort.
  Bennett AJ, Sovio U, Ruokonen A, Martikainen H, Pouta A, Taponen S, Hartikainen AL, King VJ, Elliott P, Järvelin MR, McCarthy MI
  Diabetes. 2004
  PubMed ID: 15277396
   
  
• Insulin and messenger ribonucleic acid expression of insulin receptor isoforms in ovarian follicles from nonhirsute ovulatory women and polycystic ovary syndrome patients.
  Phy JL, Conover CA, Abbott DH, Zschunke MA, Walker DL, Session DR, Tummon IS, Thornhill AR, Lesnick TG, Dumesic DA
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15240646
   
  
• Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?
  Kino T, Chrousos GP
  Ann N Y Acad Sci. 2004
  PubMed ID: 15265780
   
  
• Intravenous insulin decreases protein breakdown in infants on extracorporeal membrane oxygenation.
  Agus MS, Javid PJ, Ryan DP, Jaksic T
  J Pediatr Surg. 2004
  PubMed ID: 15185208
   
  
• Large-scale studies of the HphI insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release.
  Hansen SK, Gjesing AP, Rasmussen SK, Glümer C, Urhammer SA, Andersen G, Rose CS, Drivsholm T, Torekov SK, Jensen DP, Ekstrøm CT, Borch-Johnsen K, Jørgensen T, McCarthy MI, Hansen T, Pedersen O
  Diabetologia. 2004
  PubMed ID: 15170498
   
  
• Insulin resistance, impaired early insulin response, and insulin propeptides as predictors of the development of type 2 diabetes: a population-based, 7-year follow-up study in 70-year-old men.
  Zethelius B, Hales CN, Lithell HO, Berne C
  Diabetes Care. 2004
  PubMed ID: 15161800
   
  
• Genome-wide scans reveal quantitative trait Loci on 8p and 13q related to insulin action and glucose metabolism: the San Antonio Family Heart Study.
  Cai G, Cole SA, Freeland-Graves JH, MacCluer JW, Blangero J, Comuzzie AG
  Diabetes. 2004
  PubMed ID: 15111508
   
  
• Impaired binding of insulin to erythrocyte membrane receptor and the activation of nitric oxide synthase by the hormone in human breast cancer.
  Chakraborty S, Girish GV, Sinha AK
  J Cancer Res Clin Oncol. 2004
  PubMed ID: 14986111
   
  
• Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain.
  Ong KK, Petry CJ, Barratt BJ, Ring S, Cordell HJ, Wingate DL, Pembrey ME, Todd JA, Dunger DB, Avon Longitudinal Study of Pregnancy and Childhood Study Team
  Diabetes. 2004
  PubMed ID: 15047631
   
  
• Shortened insulin analogues: marked changes in biological activity resulting from replacement of TyrB26 and N-methylation of peptide bonds in the C-terminus of the B-chain.
  Záková L, Barth T, Jirácek J, Barthová J, Zórad S
  Biochemistry. 2004
  PubMed ID: 14979729
   
  
• C-peptide colocalizes with macrophages in early arteriosclerotic lesions of diabetic subjects and induces monocyte chemotaxis in vitro.
  Marx N, Walcher D, Raichle C, Aleksic M, Bach H, Grüb M, Hombach V, Libby P, Zieske A, Homma S, Strong J
  Arterioscler Thromb Vasc Biol. 2004
  PubMed ID: 14707040
   
  
• INS VNTR is a QTL for the insulin response to oral glucose in obese children.
  Dos Santos C, Fallin D, Le Stunff C, LeFur S, Bougnères P
  Physiol Genomics. 2004
  PubMed ID: 14657411
   
  
• Insulin induces the release of vasodilator compounds from platelets by a nitric oxide-G kinase-VAMP-3-dependent pathway.
  Randriamboavonjy V, Schrader J, Busse R, Fleming I
  J Exp Med. 2004
  PubMed ID: 14744991
   
  
• Insulin decreases hepatic acute phase protein levels in severely burned children.
  Wu X, Thomas SJ, Herndon DN, Sanford AP, Wolf SE
  Surgery. 2004
  PubMed ID: 14739855
   
  
• Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
  Yoshitomi H, Zaret KS
  Development. 2004
  PubMed ID: 14736742
   
  
• Insulinomas and expression of an insulin splice variant.
  Minn AH, Kayton M, Lorang D, Hoffmann SC, Harlan DM, Libutti SK, Shalev A
  Lancet. 2004
  PubMed ID: 15070567
   
  
• Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function.
  Jeong W, Yoon HW, Lee SR, Rhee SG
  J Biol Chem. 2004
  PubMed ID: 14607844
   
  
• Polymorphism of INS VNTR is associated with glutamic acid decarboxylase antibodies and postprandial C-peptide in patients with onset of diabetes after 35 years of age.
  Matejková-Behanová M, Vanková M, Hill M, Kucera P, Cinek O, Andel M, Bendlová B
  Physiol Res. 2004
  PubMed ID: 15046555
   
  
• Polymorphisms in candidate genes for type 2 diabetes mellitus in a Mexican population with metabolic syndrome findings.
  Sánchez-Corona J, Flores-Martínez SE, Machorro-Lazo MV, Galaviz-Hernández C, Morán-Moguel MC, Perea FJ, Mújica-López KI, Vargas-Ancona L, Laviada-Molina HA, Fernández V, Pardío J, Arroyo P, Barrera H, Hanson RL
  Diabetes Res Clin Pract. 2004
  PubMed ID: 14693412
   
  
• Insulin impairs endothelium-dependent vasodilation independent of insulin sensitivity or lipid profile.
  Campia U, Sullivan G, Bryant MB, Waclawiw MA, Quon MJ, Panza JA
  Am J Physiol Heart Circ Physiol. 2004
  PubMed ID: 12946932
   
  
• FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.
  Norgaard GA, Jensen JN, Jensen J
  Dev Biol. 2003
  PubMed ID: 14651921
   
  
• Glucocorticoids and insulin sensitivity: dissociation of insulin's metabolic and vascular actions.
  Perry CG, Spiers A, Cleland SJ, Lowe GD, Petrie JR, Connell JM
  J Clin Endocrinol Metab. 2003
  PubMed ID: 14671204
   
  
• Altered cortisol metabolism in polycystic ovary syndrome: insulin enhances 5alpha-reduction but not the elevated adrenal steroid production rates.
  Tsilchorozidou T, Honour JW, Conway GS
  J Clin Endocrinol Metab. 2003
  PubMed ID: 14671189
   
  
• Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans.
  Purnell JQ, Weigle DS, Breen P, Cummings DE
  J Clin Endocrinol Metab. 2003
  PubMed ID: 14671163
   
  
• Insulin is required for prandial ghrelin suppression in humans.
  Murdolo G, Lucidi P, Di Loreto C, Parlanti N, De Cicco A, Fatone C, Fanelli CG, Bolli GB, Santeusanio F, De Feo P
  Diabetes. 2003
  PubMed ID: 14633852
   
  
• Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells.
  Bergandi L, Silvagno F, Russo I, Riganti C, Anfossi G, Aldieri E, Ghigo D, Trovati M, Bosia A
  Arterioscler Thromb Vasc Biol. 2003
  PubMed ID: 14615391
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Insulin gene VNTR genotype is associated with insulin sensitivity and secretion in infancy.
  Bazaes RA, Petry CJ, Ong KK, Avila A, Dunger DB, Mericq MV
  Clin Endocrinol (Oxf). 2003
  PubMed ID: 14616883
   
  
• Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A.
  Pandini G, Medico E, Conte E, Sciacca L, Vigneri R, Belfiore A
  J Biol Chem. 2003
  PubMed ID: 12881524
   
  
• Associations between the human insulin gene 5' VNTR and clinical variables of the renin-angiotensin system.
  Frossard PM, Parvez SH, Lestringant GG, Kureshi NS
  Neuro Endocrinol Lett. 2003
  PubMed ID: 14647005
   
  
• Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
  Hart A, Papadopoulou S, Edlund H
  Dev Dyn. 2003
  PubMed ID: 14517990
   
  
• Global haplotype diversity in the human insulin gene region.
  Stead JD, Hurles ME, Jeffreys AJ
  Genome Res. 2003
  PubMed ID: 12952878
   
  
• Structural signatures of the complex formed between 3-nitro-4-hydroxybenzoate and the Zn(II)-substituted R(6) insulin hexamer.
  Olsen HB, Leuenberger-Fisher MR, Kadima W, Borchardt D, Kaarsholm NC, Dunn MF
  Protein Sci. 2003
  PubMed ID: 12930990
   
  
• Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin.
  Koutkia P, Canavan B, Johnson ML, DePaoli A, Grinspoon S
  Am J Physiol Endocrinol Metab. 2003
  PubMed ID: 12721156
   
  
• Insulin increases CSF Abeta42 levels in normal older adults.
  Watson GS, Peskind ER, Asthana S, Purganan K, Wait C, Chapman D, Schwartz MW, Plymate S, Craft S
  Neurology. 2003
  PubMed ID: 12821730
   
  
• In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process.
  Qiao ZS, Min CY, Hua QX, Weiss MA, Feng YM
  J Biol Chem. 2003
  PubMed ID: 12624089
   
  
• Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells.
  Suzuki A, Nakauchi H, Taniguchi H
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12702762
   
  
• Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.
  Okada S, Misaka T, Matsumoto I, Watanabe H, Abe K
  FEBS Lett. 2003
  PubMed ID: 12681500
   
  
• Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men.
  Yatagai T, Nishida Y, Nagasaka S, Nakamura T, Tokuyama K, Shindo M, Tanaka H, Ishibashi S
  Endocr J. 2003
  PubMed ID: 12803245
   
  
• Tubular injury: the first symptom of hypertensive kidney involvement?
  Tylicki L, Manitius J, Łysiak-Szydłowska W, Rutkowski B
  Med Sci Monit. 2003
  PubMed ID: 12709672
   
  
• Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.
  Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P
  Dev Dyn. 2003
  PubMed ID: 12666204
   
  
• The role of PI3K in immune cells.
  Koyasu S
  Nat Immunol. 2003
  PubMed ID: 12660731
   
  
• A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
  Hua QX, Nakagawa SH, Wilken J, Ramos RR, Jia W, Bass J, Weiss MA
  Genes Dev. 2003
  PubMed ID: 12654724
   
  
• Testosterone levels in pregnant women correlate with the insulin response during the glucose tolerance test.
  Dokras A, Spaczynski RZ, Behrman HR, Duleba AJ
  Fertil Steril. 2003
  PubMed ID: 12620428
   
  
• Insulin modulates PC-1 processing and recruitment in cultured human cells.
  Menzaghi C, Di Paola R, Baj G, Funaro A, Arnulfo A, Ercolino T, Surico N, Malavasi F, Trischitta V
  Am J Physiol Endocrinol Metab. 2003
  PubMed ID: 12441313
   
  
• The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells.
  Pulkkinen MA, Spencer-Dene B, Dickson C, Otonkoski T
  Mech Dev. 2003
  PubMed ID: 12559489
   
  
• Polymorphism of the insulin gene is associated with increased prostate cancer risk.
  Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R, Chua SC
  Br J Cancer. 2003
  PubMed ID: 12610512
   
  
• The CAG repeat polymorphism in the androgen receptor gene modulates body fat mass and serum concentrations of leptin and insulin in men.
  Zitzmann M, Gromoll J, von Eckardstein A, Nieschlag E
  Diabetologia. 2003
  PubMed ID: 12637980
   
  
• Obesity, fasting plasma insulin, and C-reactive protein levels in healthy children.
  Shea S, Aymong E, Zybert P, Shamoon H, Tracy RP, Deckelbaum RJ, Basch CE
  Obes Res. 2003
  PubMed ID: 12529491
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.
  Mahy NL, Perry PE, Bickmore WA
  J Cell Biol. 2002
  PubMed ID: 12473685
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Complications of IgA nephropathy in a non-insulin-dependent diabetes model, the Akita mouse.
  Haseyama T, Fujita T, Hirasawa F, Tsukada M, Wakui H, Komatsuda A, Ohtani H, Miura AB, Imai H, Koizumi A
  Tohoku J Exp Med. 2002
  PubMed ID: 12630555
   
  
• Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans.
  Stead JD, Jeffreys AJ
  Am J Hum Genet. 2002
  PubMed ID: 12404181
   
  
• Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.
  Heller RS, Dichmann DS, Jensen J, Miller C, Wong G, Madsen OD, Serup P
  Dev Dyn. 2002
  PubMed ID: 12412008
   
  
• Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
  Fitzpatrick GV, Soloway PD, Higgins MJ
  Nat Genet. 2002
  PubMed ID: 12410230
   
  
• Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.
  Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A
  J Biol Chem. 2002
  PubMed ID: 12138094
   
  
• High insulin enhances neutrophil transendothelial migration through increasing surface expression of platelet endothelial cell adhesion molecule-1 via activation of mitogen activated protein kinase.
  Okouchi M, Okayama N, Imai S, Omi H, Shimizu M, Fukutomi T, Itoh M
  Diabetologia. 2002
  PubMed ID: 12378388
   
  
• Cellular munc18c levels can modulate glucose transport rate and GLUT4 translocation in 3T3L1 cells.
  Macaulay SL, Grusovin J, Stoichevska V, Ryan JM, Castelli LA, Ward CW
  FEBS Lett. 2002
  PubMed ID: 12297296
   
  
• Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells.
  Kitamura T, Kimura K, Jung BD, Makondo K, Sakane N, Yoshida T, Saito M
  Biochem J. 2002
  PubMed ID: 12059784
   
  
• Effects of insulin on platelet and leukocyte activity in whole blood.
  Hu H, Hjemdahl P, Li N
  Thromb Res. 2002
  PubMed ID: 12479880
   
  
• The different energetic state of the intra A-chain/domain disulfide of insulin and insulin-like growth factor 1 is mainly controlled by their B-chain/domain.
  Guo ZY, Shen L, Feng YM
  Biochemistry. 2002
  PubMed ID: 12186542
   
  
• Accessory elements, flanking DNA sequence, and promoter context play key roles in determining the efficacy of insulin and phorbol ester signaling through the malic enzyme and collagenase-1 AP-1 motifs.
  Ayala JE, Streeper RS, Svitek CA, Goldman JK, Oeser JK, O'Brien RM
  J Biol Chem. 2002
  PubMed ID: 12032154
   
  
• Dual role of insulin in transcriptional regulation of the acute phase reactant ceruloplasmin.
  Seshadri V, Fox PL, Mukhopadhyay CK
  J Biol Chem. 2002
  PubMed ID: 12029093
   
  
• Tumor necrosis factor-alpha-induced accumulation of tumor suppressor protein p53 and cyclin-dependent protein kinase inhibitory protein p21 is inhibited by insulin in ME-180S cells.
  Akca H, Yenisoy S, Yanikoglu A, Ozes ON
  Clin Chem Lab Med. 2002
  PubMed ID: 12392301
   
  
• Platelet reactivity in spontaneously diabetic rats is independent from blood glucose and insulin levels.
  Taka T, Ono H, Sasaki Y, Seki J, Yamamoto J
  Platelets. 2002
  PubMed ID: 12189018
   
  
• Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.
  Federici M, Menghini R, Mauriello A, Hribal ML, Ferrelli F, Lauro D, Sbraccia P, Spagnoli LG, Sesti G, Lauro R
  Circulation. 2002
  PubMed ID: 12135947
   
  
• The insulin gene VNTR polymorphism in Alzheimer's disease: results of a pilot study.
  Majores M, Kölsch H, Bagli M, Ptok U, Kockler M, Becker K, Rao ML, Maier W, Heun R
  J Neural Transm. 2002
  PubMed ID: 12111440
   
  
• Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha.
  Itani SI, Ruderman NB, Schmieder F, Boden G
  Diabetes. 2002
  PubMed ID: 12086926
   
  
• Insulin and leptin combine additively to reduce food intake and body weight in rats.
  Air EL, Benoit SC, Clegg DJ, Seeley RJ, Woods SC
  Endocrinology. 2002
  PubMed ID: 12021212
   
  
• Determination of insulin in a single islet of Langerhans by high-performance liquid chromatography with fluorescence detection.
  Toriumi C, Imai K
  Anal Chem. 2002
  PubMed ID: 12038757
   
  
• New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.
  Mathews CE, Langley SH, Leiter EH
  Transplantation. 2002
  PubMed ID: 11981430
   
  
• Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation.
  Whittingham JL, Scott DJ, Chance K, Wilson A, Finch J, Brange J, Guy Dodson G
  J Mol Biol. 2002
  PubMed ID: 12051853
   
  
• [The changes in plasma leptin, insulin and proinsulin levels in obese adolescents]
  Zhang J, Gao Y, Guo X, Dong A
  Zhonghua Nei Ke Za Zhi. 2002
  PubMed ID: 12133430
   
  
• Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women.
  Calvo RM, Tellería D, Sancho J, San Millán JL, Escobar-Morreale HF
  Fertil Steril. 2002
  PubMed ID: 11937112
   
  
• Metabolic cardiovascular syndrome in obese prepubertal children: the role of high fasting insulin levels.
  Valle M, Gascón F, Martos R, Ruz FJ, Bermudo F, Morales R, Cañete R
  Metabolism. 2002
  PubMed ID: 11912547
   
  
• [Relation between insulin-like growth factor-1 and insulin resistance in patients with acute stroke]
  Fu X, Lu Y, Lu K, Liao J
  Zhonghua Yi Xue Za Zhi. 2002
  PubMed ID: 11953210
   
  
• Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D.
  Authier F, Metioui M, Fabrega S, Kouach M, Briand G
  J Biol Chem. 2002
  PubMed ID: 11779865
   
  
• Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
  Xu B, Hua QX, Nakagawa SH, Jia W, Chu YC, Katsoyannis PG, Weiss MA
  J Mol Biol. 2002
  PubMed ID: 11866509
   
  
• Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
  Weiss MA, Wan Z, Zhao M, Chu YC, Nakagawa SH, Burke GT, Jia W, Hellmich R, Katsoyannis PG
  J Mol Biol. 2002
  PubMed ID: 11779231
   
  
• Insulin signalling and the regulation of glucose and lipid metabolism.
  Saltiel AR, Kahn CR
  Nature. 2001
  PubMed ID: 11742412
   
  
• Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.
  Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R
  Development. 2001
  PubMed ID: 11748146
   
  
• Insulin gene variable number of tandem repeat genotype and the low birth weight, precocious pubarche, and hyperinsulinism sequence.
  Ibáñez L, Ong K, Potau N, Marcos MV, de Zegher F, Dunger D
  J Clin Endocrinol Metab. 2001
  PubMed ID: 11739440
   
  
• Semiquantitative polymerase chain reaction in RNase-producing tissues: Analysis of the developing pancreas.
  Hembree MJ, Prasadan K, Manna P, Preuett B, Spilde T, Bhatia A, Kobayashi H, Buckingham B, Snyder CL, Gittes GK
  J Pediatr Surg. 2001
  PubMed ID: 11685688
   
  
• Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes.
  Guz Y, Nasir I, Teitelman G
  Endocrinology. 2001
  PubMed ID: 11606464
   
  
• Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.
  Choi JD, Underkoffler LA, Collins JN, Marchegiani SM, Terry NA, Beechey CV, Oakey RJ
  Mamm Genome. 2001
  PubMed ID: 11668390
   
  
• Systematic search for single nucleotide polymorphisms in the insulin gene: evidence for a high frequency of -23T-->A in Japanese subjects.
  Osawa H, Onuma H, Murakami A, Ochi M, Nishimiya T, Kato K, Shimizu I, Fujii Y, Ohashi J, Makino H
  Biochem Biophys Res Commun. 2001
  PubMed ID: 11511079
   
  
• A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus.
  Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, Oshimura M, Wake N, Surani MA
  Hum Mol Genet. 2001
  PubMed ID: 11448939
   
  
• Insulin inhibits intranuclear nuclear factor kappaB and stimulates IkappaB in mononuclear cells in obese subjects: evidence for an anti-inflammatory effect?
  Dandona P, Aljada A, Mohanty P, Ghanim H, Hamouda W, Assian E, Ahmad S
  J Clin Endocrinol Metab. 2001
  PubMed ID: 11443198
   
  
• Polymorphisms of the insulin gene among Japanese subjects.
  Oda N, Nakai A, Fujiwara K, Imamura S, Fujita T, Hamagishi M, Kato T, Kobayashi T, Himeno Y, Yamamoto K, Makino M, Kakizawa H, Sawai Y, Itoh M, Nagasaka A
  Metabolism. 2001
  PubMed ID: 11398136
   
  
• Subcellular localization of insulin receptor substrate family proteins associated with phosphatidylinositol 3-kinase activity and alterations in lipolysis in primary mouse adipocytes from IRS-1 null mice.
  Tsuji Y, Kaburagi Y, Terauchi Y, Satoh S, Kubota N, Tamemoto H, Kraemer FB, Sekihara H, Aizawa S, Akanuma Y, Tobe K, Kimura S, Kadowaki T
  Diabetes. 2001
  PubMed ID: 11375348
   
  
• Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins.
  Liu YF, Paz K, Herschkovitz A, Alt A, Tennenbaum T, Sampson SR, Ohba M, Kuroki T, LeRoith D, Zick Y
  J Biol Chem. 2001
  PubMed ID: 11278339
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• In vitro fertilization causes epigenetic modifications to the onset of gene expression from the zygotic genome in mice.
  Stojanov T, O'Neill C
  Biol Reprod. 2001
  PubMed ID: 11159375
   
  
• Familial obesity, sympathetic activation and blood pressure level.
  Masuo K, Mikami H, Ogihara T, Tuck ML
  Blood Press. 2001
  PubMed ID: 11800057
   
  
• Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A.
  Scalia P, Heart E, Comai L, Vigneri R, Sung CK
  J Cell Biochem. 2001
  PubMed ID: 11500939
   
  
• Identification of insulin domains important for binding to and degradation by endosomal acidic insulinase.
  Authier F, Danielsen GM, Kouach M, Briand G, Chauvet G
  Endocrinology. 2001
  PubMed ID: 11145591
   
  
• FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.
  Ohuchi H, Hori Y, Yamasaki M, Harada H, Sekine K, Kato S, Itoh N
  Biochem Biophys Res Commun. 2000
  PubMed ID: 11062007
   
  
• A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.
  Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP
  Clin Genet. 2000
  PubMed ID: 11140838
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.
  Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP
  Genome Res. 2000
  PubMed ID: 11076855
   
  
• Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
  Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W, Walter J
  Hum Mol Genet. 2000
  PubMed ID: 11063728
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Effect of hypoglycemia on amino acid and protein metabolism in healthy humans.
  Battezzati A, Benedini S, Fattorini A, Piceni Sereni L, Luzi L
  Diabetes. 2000
  PubMed ID: 10969839
   
  
• Phemx, a novel mouse gene expressed in hematopoietic cells maps to the imprinted cluster on distal chromosome 7.
  Nicholson RH, Pantano S, Eliason JF, Galy A, Weiler S, Kaplan J, Hughes MR, Ko MS
  Genomics. 2000
  PubMed ID: 10950922
   
  
• Nuclear colocalization and complex formation of insulin with retinoblastoma protein in HepG2 human hepatoma cells.
  Radulescu RT, Doklea ED, Kehe K, Mückter H
  J Endocrinol. 2000
  PubMed ID: 10938588
   
  
• Notch gene expression during pancreatic organogenesis.
  Lammert E, Brown J, Melton DA
  Mech Dev. 2000
  PubMed ID: 10842072
   
  
• Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
  Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
  Development. 2000
  PubMed ID: 10725249
   
  
• Bovine and human insulin activate CD8+-autoreactive CTL expressing both type 1 and type 2 cytokines in C57BL/6 mice.
  Ma H, Ke Y, Li Q, Kapp JA
  J Immunol. 2000
  PubMed ID: 10604997
   
  
• Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
  Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H
  DNA Res. 1999
  PubMed ID: 10691133
   
  
• Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.
  Burren CP, Wilson EM, Hwa V, Oh Y, Rosenfeld RG
  J Clin Endocrinol Metab. 1999
  PubMed ID: 10084601
   
  
• The sins of the fathers and mothers: genomic imprinting in mammalian development.
  Tilghman SM
  Cell. 1999
  PubMed ID: 9988214
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Mechanism of imprinting on mouse distal chromosome 7.
  Ainscough JF, John RM, Surani MA
  Genet Res. 1998
  PubMed ID: 10036981
   
  
• Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system.
  Hunter SJ, Garvey WT
  Am J Med. 1998
  PubMed ID: 9809695
   
  
• Megalin is an endocytic receptor for insulin.
  Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, Farquhar MG
  J Am Soc Nephrol. 1998
  PubMed ID: 9773776
   
  
• Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription.
  Streeper RS, Eaton EM, Ebert DH, Chapman SC, Svitek CA, O'Brien RM
  Proc Natl Acad Sci U S A. 1998
  PubMed ID: 9689059
   
  
• Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
  Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J
  Hum Mol Genet. 1998
  PubMed ID: 9618174
   
  
• Familial hyperproinsulinaemia due to a mutation substituting histidine for arginine at position 65 in proinsulin: identification of the mutation by restriction enzyme mapping.
  Collinet M, Berthelon M, Bénit P, Laborde K, Desbuquois B, Munnich A, Robert JJ
  Eur J Pediatr. 1998
  PubMed ID: 9667398
   
  
• Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
  Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM
  Mol Cell Biol. 1998
  PubMed ID: 9584186
   
  
• Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.
  Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D
  J Biol Chem. 1998
  PubMed ID: 9507006
   
  
• Imprinting of mouse Kvlqt1 is developmentally regulated.
  Gould TD, Pfeifer K
  Hum Mol Genet. 1998
  PubMed ID: 9467008
   
  
• Effects of insulin on wound healing.
  Pierre EJ, Barrow RE, Hawkins HK, Nguyen TT, Sakurai Y, Desai M, Wolfe RR, Herndon DN
  J Trauma. 1998
  PubMed ID: 9498508
   
  
• Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions.
  Duvillié B, Bucchini D, Tang T, Jami J, Pàldi A
  Genomics. 1998
  PubMed ID: 9465295
   
  
• The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns.
  Greally JM, Starr DJ, Hwang S, Song L, Jaarola M, Zemel S
  Hum Mol Genet. 1998
  PubMed ID: 9384608
   
  
• Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.
  Yamanaka Y, Wilson EM, Rosenfeld RG, Oh Y
  J Biol Chem. 1997
  PubMed ID: 9388210
   
  
• Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas.
  Apelqvist A, Ahlgren U, Edlund H
  Curr Biol. 1997
  PubMed ID: 9368764
   
  
• Expression of homeobox genes, including an insulin promoting factor, in the murine yolk sac at the time of hematopoietic initiation.
  McGrath KE, Palis J
  Mol Reprod Dev. 1997
  PubMed ID: 9291463
   
  
• Solution structures of the R6 human insulin hexamer,.
  Chang X, Jorgensen AM, Bardrum P, Led JJ
  Biochemistry. 1997
  PubMed ID: 9235985
   
  
• Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome.
  Reik W, Maher ER
  Trends Genet. 1997
  PubMed ID: 9260520
   
  
• The gene encoding the heart/muscle isoform of cytochrome c oxidase subunit VIII maps to mouse chromosome 7.
  Makris GJ, Lomax MI
  Mamm Genome. 1997
  PubMed ID: 9166597
   
  
• Structure of the human gene (COX6A2) for the heart/muscle isoform of cytochrome c oxidase subunit VIa and its chromosomal location in humans, mice, and cattle.
  Bachman NJ, Riggs PK, Siddiqui N, Makris GJ, Womack JE, Lomax MI
  Genomics. 1997
  PubMed ID: 9177785
   
  
• A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice.
  Yoshioka M, Kayo T, Ikeda T, Koizumi A
  Diabetes. 1997
  PubMed ID: 9133560
   
  
• Insulin-induced activation of NADPH-dependent H2O2 generation in human adipocyte plasma membranes is mediated by Galphai2.
  Krieger-Brauer HI, Medda PK, Kather H
  J Biol Chem. 1997
  PubMed ID: 9092559
   
  
• Matrix-attachment regions in the mouse chromosome 7F imprinted domain.
  Greally JM, Guinness ME, McGrath J, Zemel S
  Mamm Genome. 1997
  PubMed ID: 9337391
   
  
• Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene.
  Okazaki T, Ogawa Y, Tamura N, Mori K, Isse N, Aoki T, Rochelle JM, Taketo MM, Seldin MF, Nakao K
  Genomics. 1996
  PubMed ID: 8938454
   
  
• Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.
  Sasaki H, Shimozaki K, Zubair M, Aoki N, Ohta K, Hatano N, Moore T, Feil R, Constancia M, Reik W, Rotwein P
  DNA Res. 1996
  PubMed ID: 9039503
   
  
• Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation.
  Kohn AD, Takeuchi F, Roth RA
  J Biol Chem. 1996
  PubMed ID: 8702995
   
  
• The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein.
  Krapp A, Knöfler M, Frutiger S, Hughes GJ, Hagenbüchle O, Wellauer PK
  EMBO J. 1996
  PubMed ID: 8861960
   
  
• Msx3: a novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system.
  Wang W, Chen X, Xu H, Lufkin T
  Mech Dev. 1996
  PubMed ID: 8887328
   
  
• Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis.
  Tolosano E, Cutufia MA, Hirsch E, Stefanuto G, Voyron S, Fasolo A, Silengo L, Altruda F
  Eur J Neurosci. 1996
  PubMed ID: 8963443
   
  
• PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
  Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV
  Development. 1996
  PubMed ID: 8631275
   
  
• Clarification of the Ins2 gene sequence: relevance to glucose intolerance in NON/Lt mice.
  Pearce RB, Peterson CM
  Mamm Genome. 1996
  PubMed ID: 8835532
   
  
• Identification of the site of glycation of human insulin.
  O'Harte FP, Højrup P, Barnett CR, Flatt PR
  Peptides. 1996
  PubMed ID: 8971927
   
  
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B.
  Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA
  Nature. 1995
  PubMed ID: 8524413
   
  
• Brief report: impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function.
  O'Rahilly S, Gray H, Humphreys PJ, Krook A, Polonsky KS, White A, Gibson S, Taylor K, Carr C
  N Engl J Med. 1995
  PubMed ID: 7477119
   
  
• An enhancer deletion affects both H19 and Igf2 expression.
  Leighton PA, Saam JR, Ingram RS, Stewart CL, Tilghman SM
  Genes Dev. 1995
  PubMed ID: 7544754
   
  
• Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms.
  Kotzke G, Schütt M, Missler U, Moller DE, Fehm HL, Klein HH
  Diabetologia. 1995
  PubMed ID: 7556975
   
  
• Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.
  Deltour L, Montagutelli X, Guenet JL, Jami J, Páldi A
  Dev Biol. 1995
  PubMed ID: 7729600
   
  
• Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
  Warden CH, Fisler JS, Shoemaker SM, Wen PZ, Svenson KL, Pace MJ, Lusis AJ
  J Clin Invest. 1995
  PubMed ID: 7706460
   
  
• Localization of the murine cholecystokinin A and B receptor genes.
  Samuelson LC, Isakoff MS, Lacourse KA
  Mamm Genome. 1995
  PubMed ID: 7613026
   
  
• Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
  Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A
  Nat Genet. 1995
  PubMed ID: 7773285
   
  
• Developmental patterns of histamine-like immunoreactivity in the mouse.
  Nissinen MJ, Panula P
  J Histochem Cytochem. 1995
  PubMed ID: 7822777
   
  
• Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein.
  Radulescu RT, Bellitti MR, Ruvo M, Cassani G, Fassina G
  Biochem Biophys Res Commun. 1995
  PubMed ID: 7818556
   
  
• Mapping of the genes for four members of the transmembrane 4 superfamily: mouse Cd9, Cd63, Cd81, and Cd82.
  Seldin MF, Rochelle JM, Tomlinson MG, Wright MD
  Immunogenetics. 1995
  PubMed ID: 7590978
   
  
• Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
  Ko MS, Wang X, Horton JH, Hagen MD, Takahashi N, Maezaki Y, Nadeau JH
  Mamm Genome. 1994
  PubMed ID: 8043949
   
  
• Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
  Fehmann HC, Strowski M, Göke B
  Metabolism. 1994
  PubMed ID: 7911222
   
  
• Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma.
  Kao PC, Taylor RL, Service FJ
  J Clin Endocrinol Metab. 1994
  PubMed ID: 8175958
   
  
• Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
  Rowe LB, Nadeau JH, Turner R, Frankel WN, Letts VA, Eppig JT, Ko MS, Thurston SJ, Birkenmeier EH
  Mamm Genome. 1994
  PubMed ID: 8075499
   
  
• Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting.
  Giddings SJ, King CD, Harman KW, Flood JF, Carnaghi LR
  Nat Genet. 1994
  PubMed ID: 8012396
   
  
• The search for imprinted genes.
  Bartolomei MS
  Nat Genet. 1994
  PubMed ID: 8012378
   
  
• Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226.
  Freund GG, Kulas DT, Mooney RA
  J Immunol. 1993
  PubMed ID: 7688386
   
  
• Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation.
  Rosen KM, Wentworth BM, Rosenthal N, Villa-Komaroff L
  Endocrinology. 1993
  PubMed ID: 8393762
   
  
• Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor.
  Feener EP, Backer JM, King GL, Wilden PA, Sun XJ, Kahn CR, White MF
  J Biol Chem. 1993
  PubMed ID: 8496180
   
  
• Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.
  Soos MA, Field CE, Siddle K
  Biochem J. 1993
  PubMed ID: 8452530
   
  
• Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
  Hua QX, Shoelson SE, Inouye K, Weiss MA
  Proc Natl Acad Sci U S A. 1993
  PubMed ID: 8421693
   
  
• Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.
  Deltour L, Leduque P, Blume N, Madsen O, Dubois P, Jami J, Bucchini D
  Proc Natl Acad Sci U S A. 1993
  PubMed ID: 8421685
   
  
• Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.
  Watson ML, Rao JK, Gilkeson GS, Ruiz P, Eicher EM, Pisetsky DS, Matsuzawa A, Rochelle JM, Seldin MF
  J Exp Med. 1992
  PubMed ID: 1460423
   
  
• Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.
  Jørgensen AM, Kristensen SM, Led JJ, Balschmidt P
  J Mol Biol. 1992
  PubMed ID: 1433291
   
  
• Localization of insulin-2 (Ins-2) and the obesity mutant tubby (tub) to distinct regions of mouse chromosome 7.
  Jones JM, Meisler MH, Seldin MF, Lee BK, Eicher EM
  Genomics. 1992
  PubMed ID: 1358794
   
  
• Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2.
  Zemel S, Bartolomei MS, Tilghman SM
  Nat Genet. 1992
  PubMed ID: 1303252
   
  
• A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
  Yano H, Kitano N, Morimoto M, Polonsky KS, Imura H, Seino Y
  J Clin Invest. 1992
  PubMed ID: 1601997
   
  
• Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
  Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z
  Genes Dev. 1992
  PubMed ID: 1317321
   
  
• A variant insulin promoter in non-insulin-dependent diabetes mellitus.
  Olansky L, Welling C, Giddings S, Adler S, Bourey R, Dowse G, Serjeantson S, Zimmet P, Permutt MA
  J Clin Invest. 1992
  PubMed ID: 1569197
   
  
• [Cloning, primary structure determination and expression of preproinsulin cDNA from human insulinoma in Escherichia coli]
  Chekhranova MK, Shuvalova ER, Kutin AM, Butnev VIu, Valentsova AB, Il'ina EN, Pankov IuA
  Mol Biol (Mosk). 1992
  PubMed ID: 1406615
   
  
• Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization.
  Mori M, Ishizaki K, Serikawa T, Yamada J
  Cytogenet Cell Genet. 1992
  PubMed ID: 1346376
   
  
• Proteolytic activity and cleavage specificity of cathepsin E at the physiological pH as examined towards the B chain of oxidized insulin.
  Athauda SB, Takahashi T, Inoue H, Ichinose M, Takahashi K
  FEBS Lett. 1991
  PubMed ID: 1959628
   
  
• Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition.
  Hua QX, Weiss MA
  Biochemistry. 1991
  PubMed ID: 2036420
   
  
• The interaction of proinsulin with the insulin-like growth factor-I receptor in human liver, muscle, and adipose tissue.
  Burguera B, Frank BH, DiMarchi R, Long S, Caro JF
  J Clin Endocrinol Metab. 1991
  PubMed ID: 1851182
   
  
• Two-dimensional NMR studies of Des-(B26-B30)-insulin: sequence-specific resonance assignments and effects of solvent composition.
  Hua QX, Weiss MA
  Biochim Biophys Acta. 1991
  PubMed ID: 1646635
   
  
• Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons.
  Rotwein P, Hall LJ
  DNA Cell Biol. 1990
  PubMed ID: 1702294
   
  
• Toward the solution structure of human insulin: sequential 2D 1H NMR assignment of a des-pentapeptide analogue and comparison with crystal structure.
  Hua QX, Weiss MA
  Biochemistry. 1990
  PubMed ID: 2271664
   
  
• A molecular genetic linkage map of mouse chromosome 7.
  Saunders AM, Seldin MF
  Genomics. 1990
  PubMed ID: 1981054
   
  
• Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells.
  Telford NA, Hogan A, Franz CR, Schultz GA
  Mol Reprod Dev. 1990
  PubMed ID: 1701096
   
  
• Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.
  Sawa T, Ohgaku S, Morioka H, Yano S
  J Mol Endocrinol. 1990
  PubMed ID: 2397023
   
  
• Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by pol
  Barbetti F, Raben N, Kadowaki T, Cama A, Accili D, Gabbay KH, Merenich JA, Taylor SI, Roth J
  J Clin Endocrinol Metab. 1990
  PubMed ID: 2196279
   
  
• Proinsulin I and II gene expression in inbred mouse strains.
  Koranyi L, Permutt MA, Chirgwin JM, Giddings SJ
  Mol Endocrinol. 1989
  PubMed ID: 2608062
   
  
• Mutation of the high cysteine region of the human insulin receptor alpha-subunit increases insulin receptor binding affinity and transmembrane signaling.
  Rafaeloff R, Patel R, Yip C, Goldfine ID, Hawley DM
  J Biol Chem. 1989
  PubMed ID: 2550426
   
  
• A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.
  Chan SJ, Seino S, Gruppuso PA, Schwartz R, Steiner DF
  Proc Natl Acad Sci U S A. 1987
  PubMed ID: 3470784
   
  
• Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val----Leu) isolated from the pancreas.
  Sakura H, Iwamoto Y, Sakamoto Y, Kuzuya T, Hirata H
  J Clin Invest. 1986
  PubMed ID: 3537011
   
  
• Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose.
  Ellis L, Clauser E, Morgan DO, Edery M, Roth RA, Rutter WJ
  Cell. 1986
  PubMed ID: 3518947
   
  
• Diabetes due to secretion of a structurally abnormal insulin (insulin Wakayama). Clinical and functional characteristics of [LeuA3] insulin.
  Nanjo K, Sanke T, Miyano M, Okai K, Sowa R, Kondo M, Nishimura S, Iwo K, Miyamura K, Given BD
  J Clin Invest. 1986
  PubMed ID: 3511099
   
  
• Characterization of the two nonallelic genes encoding mouse preproinsulin.
  Wentworth BM, Schaefer IM, Villa-Komaroff L, Chirgwin JM
  J Mol Evol. 1986
  PubMed ID: 3104603
   
  
• RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.
  Soares MB, Schon E, Henderson A, Karathanasis SK, Cate R, Zeitlin S, Chirgwin J, Efstratiadis A
  Mol Cell Biol. 1985
  PubMed ID: 2427930
   
  
• Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia.
  Shibasaki Y, Kawakami T, Kanazawa Y, Akanuma Y, Takaku F
  J Clin Invest. 1985
  PubMed ID: 4019786
   
  
• Familial hyperproinsulinemia due to a proposed defect in conversion of proinsulin to insulin.
  Gruppuso PA, Gorden P, Kahn CR, Cornblath M, Zeller WP, Schwartz R
  N Engl J Med. 1984
  PubMed ID: 6382002
   
  
• Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo.
  Kozak M
  Nature. 1984
  PubMed ID: 6700727
   
  
• Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.
  
  Cytogenet Cell Genet. 1984
  PubMed ID: 6690234
   
  
• Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution.
  Shoelson S, Fickova M, Haneda M, Nahum A, Musso G, Kaiser ET, Rubenstein AH, Tager H
  Proc Natl Acad Sci U S A. 1983
  PubMed ID: 6424111
   
  
• Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulin.
  Haneda M, Chan SJ, Kwok SC, Rubenstein AH, Steiner DF
  Proc Natl Acad Sci U S A. 1983
  PubMed ID: 6312455
   
  
• Action of human liver cathepsin B on the oxidized insulin B chain.
  McKay MJ, Offermann MK, Barrett AJ, Bond JS
  Biochem J. 1983
  PubMed ID: 6351842
   
  
• Genetic control of insulin receptors.
  Goldfeld AE, Rubin CS, Siegel TW, Shaw PA, Schiffer SG, Gluecksohn-Waelsch S
  Proc Natl Acad Sci U S A. 1981
  PubMed ID: 7031649
   
  
• Localization of the human insulin gene to the distal end of the short arm of chromosome 11.
  Harper ME, Ullrich A, Saunders GF
  Proc Natl Acad Sci U S A. 1981
  PubMed ID: 7027261
   
  
• Analysis of the regions flanking the human insulin gene and sequence of an Alu family member.
  Bell GI, Pictet R, Rutter WJ
  Nucleic Acids Res. 1980
  PubMed ID: 6253909
   
  
• Genetic variation in the human insulin gene.
  Ullrich A, Dull TJ, Gray A, Brosius J, Sures I
  Science. 1980
  PubMed ID: 6248962
   
  
• Nucleotide sequence of human preproinsulin complementary DNA.
  Sures I, Goeddel DV, Gray A, Ullrich A
  Science. 1980
  PubMed ID: 6927840
   
  
• Sequence of the human insulin gene.
  Bell GI, Pictet RL, Rutter WJ, Cordell B, Tischer E, Goodman HM
  Nature. 1980
  PubMed ID: 6243748
   
  
• Diabetes due to secretion of an abnormal insulin.
  Given BD, Mako ME, Tager HS, Baldwin D, Markese J, Rubenstein AH, Olefsky J, Kobayashi M, Kolterman O, Poucher R
  N Engl J Med. 1980
  PubMed ID: 7350438
   
  
• Nucleotide sequence of a cDNA clone encoding human preproinsulin.
  Bell GI, Swain WF, Pictet R, Cordell B, Goodman HM, Rutter WJ
  Nature. 1979
  PubMed ID: 503234
   
  
• The structure and evolution of the two nonallelic rat preproinsulin genes.
  Lomedico P, Rosenthal N, Efstratidadis A, Gilbert W, Kolodner R, Tizard R
  Cell. 1979
  PubMed ID: 498284
   
  
• Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II.
  Chan SJ, Noyes BE, Agarwal KL, Steiner DF
  Proc Natl Acad Sci U S A. 1979
  PubMed ID: 388427
   
  
• Effects of altered thyroid function on galactosyl diacylglycerol metabolism in myelinating rat brain.
  Flynn TJ, Deshmukh DS, Pieringer RA
  J Biol Chem. 1977
  PubMed ID: 195962
   
  
• Glucagon regulation of plasma ketone body concentration in human diabetes.
  Schade DS, Eaton RP
  J Clin Invest. 1975
  PubMed ID: 1184755
   
  
• [Total synthesis of human insulin under directed formation of the disulfide bonds]
  Sieber P, Kamber B, Hartmann A, Jöhl A, Riniker B, Rittel W
  Helv Chim Acta. 1974
  PubMed ID: 4443293
   
  
• Studies on polypeptides, IV. The synthesis of C-peptide of human proinsulin.
  Naithani VK
  Hoppe Seylers Z Physiol Chem. 1973
  PubMed ID: 4803504
   
  
• [Synthesis of peptides with the properties of human proinsulin C peptides ( h C peptide). 3. Synthesis of the sequences 14-17 and 9-13 of human proinsulin C peptides]
  Geiger R, Volk A
  Chem Ber. 1973
  PubMed ID: 4698555
   
  
• [Synthesis of peptides with the properties of human proinsulin C peptides (hC peptide). I. Scheme for the synthesis and preparation of the sequence 28-31 of human proinsulin C peptide]
  Geiger R, Jäger G, König W, Treuth G
  Chem Ber. 1973
  PubMed ID: 4698553
   
  
• Primary structures of the proinsulin connecting peptides of the rat and the horse.
  Tager HS, Steiner DF
  J Biol Chem. 1972
  PubMed ID: 4640931
   
  
• Amino acid sequence of the two insulins from mouse (Maus musculus).
  Bünzli HF, Glatthaar B, Kunz P, Mülhaupt E, Humbel RE
  Hoppe Seylers Z Physiol Chem. 1972
  PubMed ID: 5063718
   
  
• Rat-proinsulin C-peptides. Amino-acid sequences.
  Markussen J, Sundby F
  Eur J Biochem. 1972
  PubMed ID: 4554104
   
  
• The amino acid sequence of the C-peptide of human proinsulin.
  Ko AS, Smyth DG, Marktussen J, Sundby F
  Eur J Biochem. 1971
  PubMed ID: 5560404
   
  
• Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide.
  Oyer PE, Cho S, Peterson JD, Steiner DF
  J Biol Chem. 1971
  PubMed ID: 5101771
   
  
• Proinsulin and the biosynthesis of insulin.
  Steiner DF, Clark JL, Nolan C, Rubenstein AH, Margoliash E, Aten B, Oyer PE
  Recent Prog Horm Res. 1969
  PubMed ID: 4311938
   
  
• Amino-acid sequence of human insulin.
  NICOL DS, SMITH LF
  Nature. 1960
  PubMed ID: 14426955
   
  
• Chemistry of insulin; determination of the structure of insulin opens the way to greater understanding of life processes.
  SANGER F
  Science. 1959
  PubMed ID: 13658959
   
  
• The publication is not currently in our database, click on the link below to see it on pubmed.
  PubMed ID: 20301620