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IL7R

Gene Description:   interleukin 7 receptor Synonyms:   CDW127, ILRA, IL7R, IL7RA, IL-7Ralpha, CD127, IL-7R-alpha, MGC107557, Il7r Orthologs:   Human IL7R (protein-coding), Mouse Il7r (protein-coding), Rat Il7r (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Rat: 1

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm32	Rat	chr2:30109071..79796790	49.69	199

(Human) GRCh37 - chr5:35852797..35879705 (26.91 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr15:9435914..9459631 (23.72 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr2:59103992..59128004 (241 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas                 no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for IL7R: The IL7R interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs IL7R   PTK2B   HPRD, BioGRID  empirical  10702271  IL7R   FYN   HPRD  empirical  7515933  IL7R   IL2RG   HPRD  empirical  8266077  IL7R   IL7   HPRD, IntAct  empirical  11858939  10390077  8266077  IL7R   JAK1   HPRD  empirical  8647212  15996891  IL7R   JAK3   HPRD  empirical  15996891  7481769  IL7R   LYN   HPRD  empirical  7515933  IL7R   PIK3R1   HPRD  empirical  7522165  IL7R   CRLF2   HPRD  empirical  11418668  IL7R   STAT3   HPRD  empirical  7719938  IL7R   STAT5A   HPRD  empirical  7719938  IL7R   STAT5B   HPRD  empirical  7719938  IL7R   TSLP   HPRD  empirical  11418668

View all

KEGG Network: 4   Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Primary immunodeficiency Human - 5340 Mouse - 5340 Rat - 5340

Biocarta: 1   IL-7 Signal Transduction Human Mouse

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 21   Regulation of DNA recombination GO:0000018 Negative regulation of T cell mediated cytotoxicity GO:0001915 Antigen binding GO:0003823 Receptor activity GO:0004872 Interleukin-7 receptor activity GO:0004917 Protein binding GO:0005515 Extracellular region GO:0005576 Plasma membrane GO:0005886 Immune response GO:0006955 Signal transduction GO:0007165 Cell surface receptor linked signaling pathway GO:0007166 Regulation of cell size GO:0008361 External side of plasma membrane GO:0009897 Positive regulation of gene expression GO:0010628 Integral to membrane GO:0016021 Cell growth GO:0016049 T cell differentiation GO:0030217 Positive regulation of T cell differentiation in thymus GO:0033089 B cell proliferation GO:0042100 Lymph node development GO:0048535 Homeostasis of number of cells GO:0048872

	KEGG Network: 4 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Primary immunodeficiency Human - 5340 Mouse - 5340 Rat - 5340
	Biocarta: 1 IL-7 Signal Transduction Human Mouse
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 21 Regulation of DNA recombination GO:0000018 Negative regulation of T cell mediated cytotoxicity GO:0001915 Antigen binding GO:0003823 Receptor activity GO:0004872 Interleukin-7 receptor activity GO:0004917 Protein binding GO:0005515 Extracellular region GO:0005576 Plasma membrane GO:0005886 Immune response GO:0006955 Signal transduction GO:0007165 Cell surface receptor linked signaling pathway GO:0007166 Regulation of cell size GO:0008361 External side of plasma membrane GO:0009897 Positive regulation of gene expression GO:0010628 Integral to membrane GO:0016021 Cell growth GO:0016049 T cell differentiation GO:0030217 Positive regulation of T cell differentiation in thymus GO:0033089 B cell proliferation GO:0042100 Lymph node development GO:0048535 Homeostasis of number of cells GO:0048872

Type 1 Diabetes Publications: 8

• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells.
  Hoe E, McKay FC, Schibeci SD, Gandhi K, Heard RN, Stewart GJ, Booth DR
  J Immunol. 2010
  PubMed ID: 20097866
   
  
• Study of the association between the CAPSL-IL7R locus and type 1 diabetes.
  Santiago JL, Alizadeh BZ, Martínez A, Espino L, de la Calle H, Fernández-Arquero M, Figueredo MA, de la Concha EG, Roep BO, Koeleman BP, Urcelay E
  Diabetologia. 2008
  PubMed ID: 18563381
   
  
• Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells.
  Banham AH
  Trends Immunol. 2006
  PubMed ID: 17045841
   
  
• CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells.
  Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA
  J Exp Med. 2006
  PubMed ID: 16818678
   
  
• Overlapping roles of CXCL13, interleukin 7 receptor alpha, and CCR7 ligands in lymph node development.
  Luther SA, Ansel KM, Cyster JG
  J Exp Med. 2003
  PubMed ID: 12732660
   
  
• Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail.
  Porter BO, Scibelli P, Malek TR
  J Immunol. 2001
  PubMed ID: 11123301
   
  
• Functional natural killer T cells in experimental mouse strains, including NK1.1- strains.
  Serizawa I, Koezuka Y, Amao H, Saito TR, Takahashi KW
  Exp Anim. 2000
  PubMed ID: 11109539
   
  

Publications: 336

• Interleukin-7 receptor alpha gene polymorphism influences multiple sclerosis risk in Asians.
  Fang L, Isobe N, Yoshimura S, Yonekawa T, Matsushita T, Masaki K, Doi H, Ochi K, Miyamoto K, Kawano Y, Kira J, South Japan Multiple Sclerosis Genetics Consortium
  Neurology. 2011
  PubMed ID: 21670443
   
  
• Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells.
  Feng X, Wang H, Takata H, Day TJ, Willen J, Hu H
  Nat Immunol. 2011
  PubMed ID: 21532575
   
  
• Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias.
  Shochat C, Tal N, Bandapalli OR, Palmi C, Ganmore I, te Kronnie G, Cario G, Cazzaniga G, Kulozik AE, Stanulla M, Schrappe M, Biondi A, Basso G, Bercovich D, Muckenthaler MU, Izraeli S
  J Exp Med. 2011
  PubMed ID: 21536738
   
  
• Prognostic significance of interleukin-7 receptor-α gene polymorphisms in allogeneic stem-cell transplantation: a confirmatory study.
  Shamim Z, Ryder LP, Christensen IJ, Toubert A, Norden J, Collin M, Jackson G, Dickinson AM, Müller K
  Transplantation. 2011
  PubMed ID: 21326139
   
  
• Recent thymic emigrants are preferentially incorporated only into the depleted T-cell pool.
  Houston EG, Higdon LE, Fink PJ
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21402911
   
  
• IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1.
  Saba I, Kosan C, Vassen L, Möröy T
  Blood. 2011
  PubMed ID: 21258009
   
  
• CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
  Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA
  J Immunol. 2011
  PubMed ID: 21300823
   
  
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
  Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD
  Nat Genet. 2011
  PubMed ID: 21297633
   
  
• The interleukin-7 receptor α chain contributes to altered homeostasis of regulatory T cells in multiple sclerosis.
  Haas J, Korporal M, Schwarz A, Balint B, Wildemann B
  Eur J Immunol. 2011
  PubMed ID: 21287555
   
  
• Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.
  Busche A, Schmitz S, Fleige H, Robbins SH, Walzer T, Stewart CA, Förster R, Messerle M, Prinz I
  J Immunol. 2011
  PubMed ID: 21270406
   
  
• Elevated IL-7 availability does not account for T cell proliferation in moderate lymphopenia.
  Osborne LC, Patton DT, Seo JH, Abraham N
  J Immunol. 2011
  PubMed ID: 21239710
   
  
• Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis.
  Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M
  J Immunol. 2011
  PubMed ID: 21217010
   
  
• Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5.
  Weinreich MA, Jameson SC, Hogquist KA
  J Immunol. 2011
  PubMed ID: 21187442
   
  
• Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data.
  Wang JH, Pappas D, De Jager PL, Pelletier D, de Bakker PI, Kappos L, Polman CH, Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Chibnik LB, Hafler DA, Matthews PM, Hauser SL, Baranzini SE, Oksenberg JR
  Genome Med. 2011
  PubMed ID: 21244703
   
  
• Bim-mediated apoptosis and PD-1/PD-L1 pathway impair reactivity of PD1(+)/CD127(-) HCV-specific CD8(+) cells targeting the virus in chronic hepatitis C virus infection.
  Larrubia JR, Benito-Martínez S, Miquel J, Calvino M, Sanz-de-Villalobos E, González-Praetorius A, Albertos S, García-Garzón S, Lokhande M, Parra-Cid T
  Cell Immunol. 2011
  PubMed ID: 21481848
   
  
• Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
  Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA
  Nat Genet. 2011
  PubMed ID: 21399635
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Variation in SNPs of the IL7Ra gene is associated with multiple sclerosis in the Iranian population.
  Heidari M, Behmanesh M, Sahraian MA
  Immunol Invest. 2011
  PubMed ID: 21190413
   
  
• The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
  Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, Van Lommel L, Waer M, Schuit F, Gysemans C, Mathieu C
  J Immunol. 2011
  PubMed ID: 21131424
   
  
• IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis.
  Walline CC, Kanakasabai S, Bright JJ
  Genes Immun. 2011
  PubMed ID: 20861865
   
  
• Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
  Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
  Mutat Res. 2010
  PubMed ID: 20800603
   
  
• [The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer].
  MING J, ZHANG Q, JIANG Y, QIU X, BAI X
  Zhongguo Fei Ai Za Zhi. 2010
  PubMed ID: 21159243
   
  
• Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes.
  Vonarbourg C, Mortha A, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Hölscher C, Hönig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A
  Immunity. 2010
  PubMed ID: 21093318
   
  
• Phenotypical and functional alterations of CD8 regulatory T cells in primary biliary cirrhosis.
  Bernuzzi F, Fenoglio D, Battaglia F, Fravega M, Gershwin ME, Indiveri F, Ansari AA, Podda M, Invernizzi P, Filaci G
  J Autoimmun. 2010
  PubMed ID: 20638239
   
  
• Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis.
  Guo F, Hildeman D, Tripathi P, Velu CS, Grimes HL, Zheng Y
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20937872
   
  
• Cytokine polymorphisms in Th1/Th2 pathway, body mass index, and risk of non-Hodgkin lymphoma.
  Chen Y, Zheng T, Lan Q, Foss F, Kim C, Chen X, Dai M, Li Y, Holford T, Leaderer B, Boyle P, Chanock SJ, Rothman N, Zhang Y
  Blood. 2010
  PubMed ID: 20952689
   
  
• Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: the role of interleukin 7 and interleukin 7 receptor α and microbial translocation.
  Rajasuriar R, Booth D, Solomon A, Chua K, Spelman T, Gouillou M, Schlub TE, Davenport M, Crowe S, Elliott J, Hoy J, Fairley C, Stewart G, Cameron P, Lewin SR
  J Infect Dis. 2010
  PubMed ID: 20812848
   
  
• A biosensor study indicating that entropy, electrostatics, and receptor glycosylation drive the binding interaction between interleukin-7 and its receptor.
  Walsh ST
  Biochemistry. 2010
  PubMed ID: 20815339
   
  
• The genetics of multiple sclerosis: an update 2010.
  Hoffjan S, Akkad DA
  Mol Cell Probes. 2010
  PubMed ID: 20450971
   
  
• Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells.
  Simonetta F, Chiali A, Cordier C, Urrutia A, Girault I, Bloquet S, Tanchot C, Bourgeois C
  Eur J Immunol. 2010
  PubMed ID: 20690182
   
  
• Soluble HIV Tat protein removes the IL-7 receptor alpha-chain from the surface of resting CD8 T cells and targets it for degradation.
  Faller EM, Sugden SM, McVey MJ, Kakal JA, MacPherson PA
  J Immunol. 2010
  PubMed ID: 20660706
   
  
• Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.
  Ammirati E, Cianflone D, Banfi M, Vecchio V, Palini A, De Metrio M, Marenzi G, Panciroli C, Tumminello G, Anzuini A, Palloshi A, Grigore L, Garlaschelli K, Tramontana S, Tavano D, Airoldi F, Manfredi AA, Catapano AL, Norata GD
  Arterioscler Thromb Vasc Biol. 2010
  PubMed ID: 20539016
   
  
• CD45 regulates migration, proliferation, and progression of double negative 1 thymocytes.
  Lai JC, Wlodarska M, Liu DJ, Abraham N, Johnson P
  J Immunol. 2010
  PubMed ID: 20624943
   
  
• Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.
  Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B
  Mol Cell. 2010
  PubMed ID: 20705244
   
  
• Accessibility control of TCR Vgamma region by STAT5.
  Tani-ichi S, Lee HC, Ye SK, Ikuta K
  Int Immunol. 2010
  PubMed ID: 20547543
   
  
• IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae.
  Shriner AK, Liu H, Sun G, Guimond M, Alugupalli KR
  J Immunol. 2010
  PubMed ID: 20505146
   
  
• Selective ablation of the YxxM motif of IL-7Ralpha suppresses lymphomagenesis but maintains lymphocyte development.
  Osborne LC, Duthie KA, Seo JH, Gascoyne RD, Abraham N
  Oncogene. 2010
  PubMed ID: 20440272
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum.
  Gao PS, Rafaels NM, Mu D, Hand T, Murray T, Boguniewicz M, Hata T, Schneider L, Hanifin JM, Gallo RL, Gao L, Beaty TH, Beck LA, Leung DY, Barnes KC
  J Allergy Clin Immunol. 2010
  PubMed ID: 20466416
   
  
• Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
  Sombekke MH, Arteta D, van de Wiel MA, Crusius JB, Tejedor D, Killestein J, Martínez A, Peña AS, Polman CH, Uitdehaag BM
  Mult Scler. 2010
  PubMed ID: 20378664
   
  
• Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response.
  Rose T, Pillet AH, Lavergne V, Tamarit B, Lenormand P, Rousselle JC, Namane A, Thèze J
  J Biol Chem. 2010
  PubMed ID: 20167604
   
  
• Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection.
  Crawley AM, Faucher S, Angel JB
  J Immunol. 2010
  PubMed ID: 20304824
   
  
• Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS).
  Rane L, Vudattu N, Bourcier K, Graniar E, Hillert J, Seyfert V, Maeurer MJ
  J Neuroimmunol. 2010
  PubMed ID: 20226540
   
  
• Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon Beta.
  Hoe E, McKay F, Schibeci S, Heard R, Stewart G, Booth D
  J Interferon Cytokine Res. 2010
  PubMed ID: 20187771
   
  
• IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7Ralpha in T cells.
  Henriques CM, Rino J, Nibbs RJ, Graham GJ, Barata JT
  Blood. 2010
  PubMed ID: 20190194
   
  
• Ontogeny of stromal organizer cells during lymph node development.
  Bénézech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, Ware CF, Anderson G, Caamaño JH
  J Immunol. 2010
  PubMed ID: 20237296
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.
  Reijmers RM, Vondenhoff MF, Roozendaal R, Kuil A, Li JP, Spaargaren M, Pals ST, Mebius RE
  J Immunol. 2010
  PubMed ID: 20208005
   
  
• IL-7 is essential for homeostatic control of T cell metabolism in vivo.
  Jacobs SR, Michalek RD, Rathmell JC
  J Immunol. 2010
  PubMed ID: 20194717
   
  
• IL-7 receptor is expressed on adult pre-B-cell acute lymphoblastic leukemia and other B-cell derived neoplasms and correlates with expression of proliferation and survival markers.
  Sasson SC, Smith S, Seddiki N, Zaunders JJ, Bryant A, Koelsch KK, Weatherall C, Munier ML, McGinley C, Yeung J, Mulligan SP, Moore J, Cooper DA, Milliken S, Kelleher AD
  Cytokine. 2010
  PubMed ID: 20060740
   
  
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• Increased bone marrow interleukin-7 (IL-7)/IL-7R levels but reduced IL-7 responsiveness in HIV-positive patients lacking CD4+ gain on antiviral therapy.
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• L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
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• Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.
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• Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.
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• Multiple sclerosis susceptibility alleles in African Americans.
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• Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
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• Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.
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• Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.
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• Variation in IL7R predisposes to sarcoid inflammation.
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• Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis.
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• CD127(low) expression in CD4+CD25(high) T cells as immune biomarker of renal function in transplant patients.
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• Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells.
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• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
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• Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
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• Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
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• Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women.
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• Thymic progenitor homing and lymphocyte homeostasis are linked via S1P-controlled expression of thymic P-selectin/CCL25.
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• Lymph sacs are not required for the initiation of lymph node formation.
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• Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.
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• E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
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• Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
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• Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
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• Intradermal administration of thymic stromal lymphopoietin induces a T cell- and eosinophil-dependent systemic Th2 inflammatory response.
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• FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis.
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• Genetic variation in immune signaling genes differentially expressed in asthmatic lung tissues.
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• IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
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• Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
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• The T244I variant of the interleukin-7 receptor-alpha gene and multiple sclerosis.
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• IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
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• A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.
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• Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.
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• Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner.
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• A unique B2 B cell subset in the intestine.
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• CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.
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• Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
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• IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
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• Constitutive expression of IL-7 receptor alpha does not support increased expansion or prevent contraction of antigen-specific CD4 or CD8 T cells following Listeria monocytogenes infection.
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• Functional interleukin-7/interleukin-7Ralpha, and SDF-1alpha/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells.
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• Permissive roles of hematopoietin and cytokine tyrosine kinase receptors in early T-cell development.
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• IL7RA polymorphisms and susceptibility to multiple sclerosis.
  O'Doherty C, Kantarci O, Vandenbroeck K
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• CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children.
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• Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.
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• Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
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• IL-7 decreases IL-7 receptor alpha (CD127) expression and induces the shedding of CD127 by human CD8+ T cells.
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• Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells.
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• Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
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• Prevention of graft-versus-host disease by anti IL-7Ralpha antibody.
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• Critical role of FLT3 ligand in IL-7 receptor independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors.
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• Crystallization and preliminary X-ray diffraction of human interleukin-7 bound to unglycosylated and glycosylated forms of its alpha-receptor.
  Wickham J, Walsh ST
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• Proteomics analysis of interleukin (IL)-7-induced signaling effectors shows selective changes in IL-7Ralpha449F knock-in T cell progenitors.
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• Direct interaction between Kit and the interleukin-7 receptor.
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• Bone marrow CD8 cells down-modulate membrane IL-7Ralpha expression and exhibit increased STAT-5 and p38 MAPK phosphorylation in the organ environment.
  Cassese G, Parretta E, Pisapia L, Santoni A, Guardiola J, Di Rosa F
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• gamma(c) cytokines provide multiple homeostatic signals to naive CD4(+) T cells.
  Masse GX, Corcuff E, Decaluwe H, Bommhardt U, Lantz O, Buer J, Di Santo JP
  Eur J Immunol. 2007
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• Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.
  Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL, Multiple Sclerosis Genetics Group
  Nat Genet. 2007
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• Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis.
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• Risk alleles for multiple sclerosis identified by a genomewide study.
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• Mesenchymal cells are required for functional development of thymic epithelial cells.
  Itoi M, Tsukamoto N, Yoshida H, Amagai T
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• Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection.
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• Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients.
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• A new subset of human naive CD8+ T cells defined by low expression of IL-7R alpha.
  Alves NL, van Leeuwen EM, Remmerswaal EB, Vrisekoop N, Tesselaar K, Roosnek E, ten Berge IJ, van Lier RA
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• Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG
  Nat Genet. 2007
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• Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors.
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• Association between genetic polymorphisms in the human interleukin-7 receptor alpha-chain and inhalation allergy.
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  Int J Immunogenet. 2007
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• Down-regulation of IL-7Ralpha expression in human T cells via DNA methylation.
  Kim HR, Hwang KA, Kim KC, Kang I
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• Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice.
  Osborne LC, Dhanji S, Snow JW, Priatel JJ, Ma MC, Miners MJ, Teh HS, Goldsmith MA, Abraham N
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• hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
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• Selective thymus settling regulated by cytokine and chemokine receptors.
  Schwarz BA, Sambandam A, Maillard I, Harman BC, Love PE, Bhandoola A
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• Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
  Hartigan-O'Connor DJ, Poon C, Sinclair E, McCune JM
  J Immunol Methods. 2007
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• Chemokine-guided CD4+ T cell help enhances generation of IL-6RalphahighIL-7Ralpha high prememory CD8+ T cells.
  Castellino F, Germain RN
  J Immunol. 2007
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• IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.
  Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA
  J Immunol. 2007
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• Role of the intracellular domain of IL-7 receptor in T cell development.
  Jiang Q, Huang J, Li WQ, Cavinato T, Keller JR, Durum SK
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• Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver.
  Bengsch B, Spangenberg HC, Kersting N, Neumann-Haefelin C, Panther E, von Weizsäcker F, Blum HE, Pircher H, Thimme R
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• Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals.
  Shklovskaya E, Fazekas de St Groth B
  J Immunol. 2006
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• Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
  Kikuchi K, Kondo M
  Proc Natl Acad Sci U S A. 2006
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• A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127.
  Vosshenrich CA, García-Ojeda ME, Samson-Villéger SI, Pasqualetto V, Enault L, Richard-Le Goff O, Corcuff E, Guy-Grand D, Rocha B, Cumano A, Rogge L, Ezine S, Di Santo JP
  Nat Immunol. 2006
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• Interleukin-7 receptor expression on CD8 T-cells is downregulated by the HIV Tat protein.
  Faller EM, McVey MJ, Kakal JA, MacPherson PA
  J Acquir Immune Defic Syndr. 2006
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• Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells.
  Yu A, Malek TR
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• Cutting edge: IL-7-independent regulation of IL-7 receptor alpha expression and memory CD8 T cell development.
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• Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates.
  García-Peydró M, de Yébenes VG, Toribio ML
  J Immunol. 2006
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• Do CD8 effector cells need IL-7R expression to become resting memory cells?
  Buentke E, Mathiot A, Tolaini M, Di Santo J, Zamoyska R, Seddon B
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• Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.
  Coles MC, Veiga-Fernandes H, Foster KE, Norton T, Pagakis SN, Seddon B, Kioussis D
  Proc Natl Acad Sci U S A. 2006
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• Age-related CD8+ T cell clonal expansions express elevated levels of CD122 and CD127 and display defects in perceiving homeostatic signals.
  Messaoudi I, Warner J, Nikolich-Zugich J
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• Phenotype of genetically regulated thymic involution in young BXD RI strains of mice.
  Wang X, Hsu HC, Wang Y, Edwards CK, Yang P, Wu Q, Mountz JD
  Scand J Immunol. 2006
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• Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation.
  Sato T, Endoh M, Yoshida H, Yasuo S, Katsuno T, Saito Y, Isono K, Koseki H
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• Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy.
  Read SW, Higgins J, Metcalf JA, Stevens RA, Rupert A, Nason MC, Lane HC, Sereti I
  J Acquir Immune Defic Syndr. 2006
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• Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells.
  Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R, Kelleher A, Fazekas de St Groth B
  J Exp Med. 2006
  PubMed ID: 16818676
   
  
• Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
  Sawa S, Kamimura D, Jin GH, Morikawa H, Kamon H, Nishihara M, Ishihara K, Murakami M, Hirano T
  J Exp Med. 2006
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• IL-7R alpha gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes.
  Swainson L, Verhoeyen E, Cosset FL, Taylor N
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• HIV regulation of the IL-7R: a viral mechanism for enhancing HIV-1 replication in human macrophages in vitro.
  Zhang M, Drenkow J, Lankford CS, Frucht DM, Rabin RL, Gingeras TR, Venkateshan C, Schwartzkopff F, Clouse KA, Dayton AI
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• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
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• Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression.
  Morrot A, Cockburn IA, Overstreet M, Rodríguez D, Zavala F
  Infect Immun. 2006
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• Altered IL-7Ralpha expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses.
  Kim HR, Hong MS, Dan JM, Kang I
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• Attenuation of IL-7 receptor signaling is not required for allelic exclusion.
  Will WM, Aaker JD, Burchill MA, Harmon IR, O'Neil JJ, Goetz CA, Hippen KL, Farrar MA
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• Genetic polymorphisms in the genes encoding human interleukin-7 receptor-alpha: prognostic significance in allogeneic stem cell transplantation.
  Shamim Z, Ryder LP, Heilmann C, Madsen H, Lauersen H, Andersen PK, Svejgaard A, Jacobsen N, Müller K
  Bone Marrow Transplant. 2006
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• Origins of peripheral B cells in IL-7 receptor-deficient mice.
  Hesslein DG, Yang SY, Schatz DG
  Mol Immunol. 2006
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• Stat5a/b are essential for normal lymphoid development and differentiation.
  Yao Z, Cui Y, Watford WT, Bream JH, Yamaoka K, Hissong BD, Li D, Durum SK, Jiang Q, Bhandoola A, Hennighausen L, O'Shea JJ
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16418296
   
  
• Molecular, cellular, and antigen requirements for development of age-associated T cell clonal expansions in vivo.
  Messaoudi I, Warner J, Nikolich-Zugich D, Fischer M, Nikolich-Zugich J
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• Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.
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• Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes.
  Zhao H, Nguyen H, Kang J
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• Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis.
  Booth DR, Arthur AT, Teutsch SM, Bye C, Rubio J, Armati PJ, Pollard JD, Heard RN, Stewart GJ, The Southern MS Genetics Consortium
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• IL-7 receptor alpha chain expression distinguishes functional subsets of virus-specific human CD8+ T cells.
  van Leeuwen EM, de Bree GJ, Remmerswaal EB, Yong SL, Tesselaar K, ten Berge IJ, van Lier RA
  Blood. 2005
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• Antisense transcription in the mammalian transcriptome.
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• The transcriptional landscape of the mammalian genome.
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• Ubiquitination of the common cytokine receptor gammac and regulation of expression by an ubiquitination/deubiquitination machinery.
  Gesbert F, Malardé V, Dautry-Varsat A
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• Cell biology of IL-7, a key lymphotrophin.
  Jiang Q, Li WQ, Aiello FB, Mazzucchelli R, Asefa B, Khaled AR, Durum SK
  Cytokine Growth Factor Rev. 2005
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• Transcriptional regulation of the mouse IL-7 receptor alpha promoter by glucocorticoid receptor.
  Lee HC, Shibata H, Ogawa S, Maki K, Ikuta K
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  PubMed ID: 15944284
   
  
• Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.
  Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran AE, Mårtensson IL
  Eur J Immunol. 2005
  PubMed ID: 15909309
   
  
• Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms.
  Min B, Yamane H, Hu-Li J, Paul WE
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• Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help.
  Fuller MJ, Hildeman DA, Sabbaj S, Gaddis DE, Tebo AE, Shang L, Goepfert PA, Zajac AJ
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• IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.
  Kikuchi K, Lai AY, Hsu CL, Kondo M
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• IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
  Okada E, Yamazaki M, Tanabe M, Takeuchi T, Nanno M, Oshima S, Okamoto R, Tsuchiya K, Nakamura T, Kanai T, Hibi T, Watanabe M
  Am J Physiol Gastrointest Liver Physiol. 2005
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• Loss of CD127 expression defines an expansion of effector CD8+ T cells in HIV-infected individuals.
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• Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis.
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• Gene and alternative splicing annotation with AIR.
  Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
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• Dynamic regulation of IL-7 receptor expression is required for normal thymopoiesis.
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• Impaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient mice.
  Erlandsson L, Licence S, Gaspal F, Bell S, Lane P, Corcoran AE, Mårtensson IL
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• Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice.
  Pellegrini M, Bouillet P, Robati M, Belz GT, Davey GM, Strasser A
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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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