FASLG

Summary Top Help

Gene Description:

Fas ligand (TNF superfamily, member 6)

Synonyms:

FASL, CD95-L, Apt1Lg1, Fasl, CD178, Faslg, FASLG, Fas-L, Tnfsf6, CD95L, gld, TNFSF6, APT1LG1

Orthologs:

Human FASLG (protein-coding), Mouse Fasl (protein-coding), Rat Faslg (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr1:172628154..172636014 (7.86 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:163710820..163718626 (7.81 kb) View in Genome Browser

(Rat) RGSC3.4 - chr13:77472950..77480210 (7.26 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for FASLG:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for FASLG:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 14

Biocarta: 13

Reactome: 6

NCI-Nature Pathway Interaction Database: 8

Gene Ontology: 38

Publications from PubMed Top Help

Type 1 Diabetes Publications: 21

Inhibition of Fas ligand in NOD mice unmasks a protective role for IL-10 against insulitis development.
Xiao Z, Mohamood AS, Uddin S, Gutfreund R, Nakata C, Marshall A, Kimura H, Caturegli P, Womer KL, Huang Y, Jie C, Chakravarti S, Schneck JP, Yagita H, Hamad AR
Am J Pathol. 2011
PubMed ID: 21718680
Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes.
Ares-Carrasco S, Picatoste B, Benito-Martín A, Zubiri I, Sanz AB, Sanchez-Miño MD, Ortiz A, Egido J, Tuñón J, Lorenzo O
Am J Physiol Heart Circ Physiol. 2009
PubMed ID: 19820199
Insulitis in human type 1 diabetes.
Hanafusa T, Imagawa A
Ann N Y Acad Sci. 2008
PubMed ID: 19120316
Dominance of cytokine- over FasL-induced impairment of the mitochondrial transmembrane potential (Deltapsim) in the pancreatic beta-cell line NIT-1.
Augstein P, Heinke P, Salzsieder E, Grimm R, Giebel J, Salzsieder C, Harrison LC
Diab Vasc Dis Res. 2008
PubMed ID: 18777493
Adenoviral-mediated overexpression of either membrane-bound human FasL or human decoy Fas can prolong pig islet xenograft survival in a rat transplant model.
Kawamoto K, Tanemura M, Saga A, Komoda H, Fumimoto Y, Deguchi T, Machida T, Sawa Y, Nishida T, Ito T
Transplant Proc. 2008
PubMed ID: 18374107
Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologically.
Mohamood AS, Guler ML, Xiao Z, Zheng D, Hess A, Wang Y, Yagita H, Schneck JP, Hamad AR
Am J Pathol. 2007
PubMed ID: 17591957
A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model.
Franke DD, Yolcu ES, Alard P, Kosiewicz MM, Shirwan H
Mol Immunol. 2007
PubMed ID: 17324464
Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance.
Nolsøe RL, Hamid YH, Pociot F, Paulsen S, Andersen KM, Borch-Johnsen K, Drivsholm T, Hansen T, Pedersen O, Mandrup-Poulsen T
Genes Immun. 2006
PubMed ID: 16691186
Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity.
Fan H, Patel VA, Longacre A, Levine JS
J Leukoc Biol. 2006
PubMed ID: 16244106
Peripheral blood cytotoxic lymphocyte gene transcript levels differ in patients with long-term type 1 diabetes compared to normal controls.
Han D, Leith J, Alejandro R, Bolton W, Ricordi C, Kenyon NS
Cell Transplant. 2005
PubMed ID: 16180659
Mechanisms of accelerated immune-mediated diabetes resulting from islet beta cell expression of a Fas ligand transgene.
Silva DG, Petrovsky N, Socha L, Slattery R, Gatenby P, Charlton B
J Immunol. 2003
PubMed ID: 12734343
Fas/Fas ligand interactions play an essential role in the initiation of murine autoimmune diabetes.
Nakayama M, Nagata M, Yasuda H, Arisawa K, Kotani R, Yamada K, Chowdhury SA, Chakrabarty S, Jin ZZ, Yagita H, Yokono K, Kasuga M
Diabetes. 2002
PubMed ID: 11978635
The role of Fas ligand in beta cell destruction in autoimmune diabetes of NOD mice.
Petrovsky N, Silva D, Socha L, Slattery R, Charlton B
Ann N Y Acad Sci. 2002
PubMed ID: 12021107
Soluble Fas ligand-susceptible "memory" cells in mice but not in human: potential role of soluble Fas ligand in deletion of auto-reactive cells.
Kim S, Ki JY, Lee TH, Suk K, Cha HS, Koh EM, Yagita H, Lee MS
Autoimmunity. 2002
PubMed ID: 11908702
Complete mutation scan of the human Fas ligand gene: linkage studies in Type I diabetes mellitus families.
Nolsøe RL, Kristiansen OP, Larsen ZM, Johannesen J, Pociot F, Mandrup-Poulsen T
Diabetologia. 2002
PubMed ID: 11845233
Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality.
Oberholzer A, Oberholzer C, Bahjat FR, Edwards CK, Moldawer LL
J Endotoxin Res. 2001
PubMed ID: 11753206
Significant role for Fas in the pathogenesis of autoimmune diabetes.
Su X, Hu Q, Kristan JM, Costa C, Shen Y, Gero D, Matis LA, Wang Y
J Immunol. 2000
PubMed ID: 10679090
Comparing the relative role of perforin/granzyme versus Fas/Fas ligand cytotoxic pathways in CD8+ T cell-mediated insulin-dependent diabetes mellitus.
Kreuwel HT, Morgan DJ, Krahl T, Ko A, Sarvetnick N, Sherman LA
J Immunol. 1999
PubMed ID: 10510373
In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.
Pakala SV, Chivetta M, Kelly CB, Katz JD
J Exp Med. 1999
PubMed ID: 10190896
Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.
Allison J, Georgiou HM, Strasser A, Vaux DL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9108084
Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice.
Lau HT, Yu M, Fontana A, Stoeckert CJ
Science. 1996
PubMed ID: 8658177

Publications: 1018

Mice with mutations in Fas and Fas ligand demonstrate increased herpetic stromal keratitis following corneal infection with HSV-1.
Morris JE, Zobell S, Yin XT, Zakeri H, Summers BC, Leib DA, Stuart PM
J Immunol. 2012
PubMed ID: 22156346
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
LaCasse CJ, Janikashvili N, Larmonier CB, Alizadeh D, Hanke N, Kartchner J, Situ E, Centuori S, Har-Noy M, Bonnotte B, Katsanis E, Larmonier N
J Immunol. 2011
PubMed ID: 22075702
Circulating CD95-ligand as a potential prognostic marker for recurrence in patients with synchronous colorectal liver metastases.
Hoogwater FJ, Snoeren N, Nijkamp MW, Gunning AC, VAN Houdt WJ, DE Bruijn MT, Voest EE, VAN Hillegersberg R, Kranenburg O, Rinkes IH
Anticancer Res. 2011
PubMed ID: 22199323
Fas/FasL pathway-mediated alveolar macrophage apoptosis involved in human silicosis.
Yao SQ, Rojanasakul LW, Chen ZY, Xu YJ, Bai YP, Chen G, Zhang XY, Zhang CM, Yu YQ, Shen FH, Yuan JX, Chen J, He QC
Apoptosis. 2011
PubMed ID: 21910009
Escherichia coli induces apoptosis in human monocytic U937 cells through the Fas/FasL signaling pathway.
Wang JH, Peng Y, Yang LL, Wang YB, Wu BG, Zhang Y, He P
Mol Cell Biochem. 2011
PubMed ID: 21691772
Mucosal memory CD8⁺ T cells are selected in the periphery by an MHC class I molecule.
Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H
Nat Immunol. 2011
PubMed ID: 21964609
Mast cell function and death in Trypanosoma cruzi infection.
Meuser-Batista M, Corrêa JR, Carvalho VF, de Carvalho Britto CF, Moreira OC, Batista MM, Soares MJ, Filho FA, E Silva PM, Lannes-Vieira J, Silva RC, Henriques-Pons A
Am J Pathol. 2011
PubMed ID: 21819958
A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer.
Sung WW, Wang YC, Cheng YW, Lee MC, Yeh KT, Wang L, Wang J, Chen CY, Lee H
Clin Cancer Res. 2011
PubMed ID: 21807637
Murine antithymocyte globulin T-cell depletion is mediated predominantly by macrophages, but the Fas/FasL pathway selectively targets regulatory T cells.
Neff KS, Richards SM, Williams JM, Garman RD, Ruzek MC
Transplantation. 2011
PubMed ID: 21804441
Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degeneration in Chinese Han population.
Zhu GB, Jiang XR, Xia CL, Sun YJ, Zeng QS, Wu XM, Li XC
Biomarkers. 2011
PubMed ID: 21806408
The mechanism of neogambogic acid-induced apoptosis in human MCF-7 cells.
Wang K, Tang Y, Sun M, Lu B, Zhu H, Ji O, Shen Q
Acta Biochim Biophys Sin (Shanghai). 2011
PubMed ID: 21785112
Fluorofenidone inhibits Ang II-induced apoptosis of renal tubular cells through blockage of the Fas/FasL pathway.
Ning WB, Hu GY, Peng ZZ, Wang L, Wang W, Chen JY, Zheng X, Li J, Tao LJ
Int Immunopharmacol. 2011
PubMed ID: 21586345
Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells.
Weiss EM, Schmidt A, Vobis D, Garbi N, Lahl K, Mayer CT, Sparwasser T, Ludwig A, Suri-Payer E, Oberle N, Krammer PH
J Immunol. 2011
PubMed ID: 21746966
A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide.
Piccioni M, Monari C, Bevilacqua S, Perito S, Bistoni F, Kozel TR, Vecchiarelli A
Clin Exp Immunol. 2011
PubMed ID: 21605112
Tgf-beta-mediated FasL-Fas-Caspase pathway is crucial during palatogenesis.
Huang X, Yokota T, Iwata J, Chai Y
J Dent Res. 2011
PubMed ID: 21593251
Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways.
Mou H, Zheng Y, Zhao P, Bao H, Fang W, Xu N
Toxicol In Vitro. 2011
PubMed ID: 21466843
Fas receptor (CD95) & Fas ligand (CD178) expression in patients with tobacco-related intraoral squamous cell carcinoma.
Das SN, Khare P, Singh MK, Sharma SC
Indian J Med Res. 2011
PubMed ID: 21808135
Matrix metalloproteinases and soluble Fas/FasL system as novel regulators of apoptosis in children and young adults on chronic dialysis.
Musiał K, Zwolińska D
Apoptosis. 2011
PubMed ID: 21516345
[Mechanism of Fas/FasL signal transduction pathway in K562 cell apoptosis induced by diallyl disulfide].
Yin XC, Peng YH, Xiao ZX
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011
PubMed ID: 21729539
Cytotoxic T lymphocyte perforin and Fas ligand working in concert even when Fas ligand lytic action is still not detectable.
Hassin D, Garber OG, Meiraz A, Schiffenbauer YS, Berke G
Immunology. 2011
PubMed ID: 21517838
S-nitrosylation of the death receptor fas promotes fas ligand-mediated apoptosis in cancer cells.
Leon-Bollotte L, Subramaniam S, Cauvard O, Plenchette-Colas S, Paul C, Godard C, Martinez-Ruiz A, Legembre P, Jeannin JF, Bettaieb A
Gastroenterology. 2011
PubMed ID: 21354149
Myeloid-derived suppressor cells express the death receptor Fas and apoptose in response to T cell-expressed FasL.
Sinha P, Chornoguz O, Clements VK, Artemenko KA, Zubarev RA, Ostrand-Rosenberg S
Blood. 2011
PubMed ID: 21450901
High soluble Fas and soluble Fas Ligand serum levels before stent implantation are protective against restenosis.
Katsaros KM, Wiesbauer F, Speidl WS, Kastl SP, Huber K, Zorn G, Niessner A, Glogar D, Maurer G, Wojta J
Thromb Haemost. 2011
PubMed ID: 21359408
Genetic polymorphisms of TP53 and FAS promoter modulate the progression of coronary artery disease after coronary artery bypass grafting: a gender-specific view.
Beiras-Fernandez A, Angele MK, Koutang C, Lohse P, Reichart B, Lohse P, Eifert S
Inflamm Res. 2011
PubMed ID: 21286777
Fas-FasL system in molar pregnancy.
Soni S, Rath G, Prasad CP, Salhan S, Jain AK, Saxena S
Am J Reprod Immunol. 2011
PubMed ID: 21087335
IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia.
Hu X, Yang D, Zimmerman M, Liu F, Yang J, Kannan S, Burchert A, Szulc Z, Bielawska A, Ozato K, Bhalla K, Liu K
Cancer Res. 2011
PubMed ID: 21487040
Deficiency of SATB1 expression in Sezary cells causes apoptosis resistance by regulating FasL/CD95L transcription.
Wang Y, Su M, Zhou LL, Tu P, Zhang X, Jiang X, Zhou Y
Blood. 2011
PubMed ID: 21270445
Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury.
Ko GJ, Jang HR, Huang Y, Womer KL, Liu M, Higbee E, Xiao Z, Yagita H, Racusen L, Hamad AR, Rabb H
J Am Soc Nephrol. 2011
PubMed ID: 21436290
The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region.
Herrero R, Kajikawa O, Matute-Bello G, Wang Y, Hagimoto N, Mongovin S, Wong V, Park DR, Brot N, Heinecke JW, Rosen H, Goodman RB, Fu X, Martin TR
J Clin Invest. 2011
PubMed ID: 21285513
Proapoptotic effect of metalloproteinase 9 secreted by trophoblasts on endothelial cells.
Xu J, Liu H, Wu Y, Gong X, Zhou Q, Qiao F
J Obstet Gynaecol Res. 2011
PubMed ID: 21159039
The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.
Dufour F, Sasseville AM, Chabaud S, Massie B, Siegel RM, Langelier Y
Apoptosis. 2011
PubMed ID: 21107701
Fas ligation and tumor necrosis factor α activation of murine astrocytes promote heat shock factor-1 activation and heat shock protein expression leading to chemokine induction and cell survival.
Choi K, Ni L, Jonakait GM
J Neurochem. 2011
PubMed ID: 21114495
Fas-ligand staining in non-drug- and drug-induced maculopapular rashes.
Wang EC, Lee JS, Tan AW, Tang MB
J Cutan Pathol. 2011
PubMed ID: 20726934
Dendritic cell co-transfected with FasL and allergen genes induces T cell tolerance and decreases airway inflammation in allergen induced murine model.
Wang Y, Bi Y, Wu K, Wang C
Mol Biol Rep. 2011
PubMed ID: 20373028
CTLs respond with activation and granule secretion when serving as targets for T-cell recognition.
Milstein O, Hagin D, Lask A, Reich-Zeliger S, Shezen E, Ophir E, Eidelstein Y, Afik R, Antebi YE, Dustin ML, Reisner Y
Blood. 2011
PubMed ID: 21045195
Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain.
Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T, Aguilar-Pimentel A, Horsch M, Michel G, Beckers J, Busch DH, Ollert M, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Staal FJ, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M
Blood. 2011
PubMed ID: 20971954
Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions.
Wu J, Richards MH, Huang J, Al-Harthi L, Xu X, Lin R, Xie F, Gibson AW, Edberg JC, Kimberly RP
PLoS One. 2011
PubMed ID: 22022540
Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians.
Kupcinskas J, Wex T, Bornschein J, Selgrad M, Leja M, Juozaityte E, Kiudelis G, Jonaitis L, Malfertheiner P
BMC Med Genet. 2011
PubMed ID: 21864388
Negative autoregulation by Fas stabilizes adult erythropoiesis and accelerates its stress response.
Koulnis M, Liu Y, Hallstrom K, Socolovsky M
PLoS One. 2011
PubMed ID: 21760888
Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer.
Gryko M, Guzińska-Ustymowicz K, Pryczynicz A, Cepowicz D, Kukliński A, Czyżewska J, Kemona A, Kędra B
Folia Histochem Cytobiol. 2011
PubMed ID: 21526501
Opposing roles for membrane bound and soluble Fas ligand in glaucoma-associated retinal ganglion cell death.
Gregory MS, Hackett CG, Abernathy EF, Lee KS, Saff RR, Hohlbaum AM, Moody KS, Hobson MW, Jones A, Kolovou P, Karray S, Giani A, John SW, Chen DF, Marshak-Rothstein A, Ksander BR
PLoS One. 2011
PubMed ID: 21479271
Role of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2 infection.
Krzyzowska M, Shestakov A, Eriksson K, Chiodi F
Cell Death Dis. 2011
PubMed ID: 21412278
Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner.
Schmich K, Schlatter R, Corazza N, Sá Ferreira K, Ederer M, Brunner T, Borner C, Merfort I
Hepatology. 2011
PubMed ID: 20872776
Renal tubular Fas ligand mediates fratricide in cisplatin-induced acute kidney failure.
Linkermann A, Himmerkus N, Rölver L, Keyser KA, Steen P, Bräsen JH, Bleich M, Kunzendorf U, Krautwald S
Kidney Int. 2011
PubMed ID: 20811331
Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility.
Villa-Morales M, González-Gugel E, Shahbazi MN, Santos J, Fernández-Piqueras J
Carcinogenesis. 2010
PubMed ID: 20889682
Fat intake interacts with polymorphisms of Caspase9, FasLigand and PPARgamma apoptotic genes in modulating Crohn's disease activity.
Ferreira P, Cravo M, Guerreiro CS, Tavares L, Santos PM, Brito M
Clin Nutr. 2010
PubMed ID: 20650551
The IFNG (IFN-gamma) genotype predicts cytogenetic and molecular response to imatinib therapy in chronic myeloid leukemia.
Kim DH, Kong JH, Byeun JY, Jung CW, Xu W, Liu X, Kamel-Reid S, Kim YK, Kim HJ, Lipton JH
Clin Cancer Res. 2010
PubMed ID: 20959405
Polymorphisms of death pathway genes FAS and FASL and risk of nasopharyngeal carcinoma.
Cao Y, Miao XP, Huang MY, Deng L, Lin DX, Zeng YX, Shao JY
Mol Carcinog. 2010
PubMed ID: 20842669
FasL expression in activated T lymphocytes involves HuR-mediated stabilization.
Drury GL, Di Marco S, Dormoy-Raclet V, Desbarats J, Gallouzi IE
J Biol Chem. 2010
PubMed ID: 20675370
MicroRNA-21 protects neurons from ischemic death.
Buller B, Liu X, Wang X, Zhang RL, Zhang L, Hozeska-Solgot A, Chopp M, Zhang ZG
FEBS J. 2010
PubMed ID: 20840605
Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells.
Tarr JM, Winyard PG, Ryan B, Harries LW, Haigh R, Viner N, Eggleton P
Arthritis Rheum. 2010
PubMed ID: 20533543
Distinct roles of cytolytic effector molecules for antigen-restricted killing by CTL in vivo.
Janssen EM, Lemmens EE, Gour N, Reboulet RA, Green DR, Schoenberger SP, Pinkoski MJ
Immunol Cell Biol. 2010
PubMed ID: 20309009
The role of MAPK-ERK pathway in 67-kDa laminin receptor-induced FasL expression in human cholangiocarcinoma cells.
Duan SG, Cheng L, Li DJ, Zhu J, Xiong Y, Li XW, Wang SG
Dig Dis Sci. 2010
PubMed ID: 20101459
[Killing effect of interleukin-18-enhanced FasL-expressing colon cancer cells on human hepatocytes in vitro].
Xu T, Hao XS, Ren XB, Zhang HL
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 21122378
Antigen-specific cytotoxicity by invariant NKT cells in vivo is CD95/CD178-dependent and is correlated with antigenic potency.
Wingender G, Krebs P, Beutler B, Kronenberg M
J Immunol. 2010
PubMed ID: 20660713
Organ microenvironment plays significant roles through Fas ligand in vaccine-induced CD4(+) T cell dependent suppression of tumor growth at the orthotopic site.
Sugiura D, Denda-Nagai K, Takeda K, Irimura T
Cancer Sci. 2010
PubMed ID: 20637014
Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma.
Zhu J, Qin C, Wang M, Yan F, Ju X, Meng X, Ding Q, Li P, Yang J, Cao Q, Zhang Z, Yin C
Mol Carcinog. 2010
PubMed ID: 20572163
Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.
Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H
Cell Death Differ. 2010
PubMed ID: 20379197
Fas ligand expression on T cells is sufficient to prevent prolonged airway inflammation in a murine model of asthma.
Tong J, Clay BS, Ferreira CM, Bandukwala HS, Moore TV, Blaine KM, Williams JW, Hoffman LM, Hamann KJ, Shilling RA, Weinstock JV, Sperling AI
Am J Respir Cell Mol Biol. 2010
PubMed ID: 19855087
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency.
Teh CE, Daley SR, Enders A, Goodnow CC
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20668237
IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells.
Wadsworth SJ, Atsuta R, McIntyre JO, Hackett TL, Singhera GK, Dorscheid DR
J Allergy Clin Immunol. 2010
PubMed ID: 20624652
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
Functional polymorphisms of the FAS/FASLG genes are associated with risk of alopecia areata in a Chinese population: a case-control analysis.
Fan X, Shangguan L, Li M, Li CY, Liu B
Br J Dermatol. 2010
PubMed ID: 20394629
Fas ligand (FasL, Apo-1L/CD95L) expression and clinical outcome in papillary microcarcinoma and papillary thyroid carcinomas with diameter smaller than 1.5 centimeters.
Bayraktaroglu T, Boztepe H, Kapran Y, Tanakol R, Alagöl F
Exp Clin Endocrinol Diabetes. 2010
PubMed ID: 20013612
[Immune evasion of human lung carcinoma cell A549 suppressed by human lymphoma cell Jurkat via Fas/FasL pathway].
Wang H, Zhang G, Dai J, Min J
Zhongguo Fei Ai Za Zhi. 2010
PubMed ID: 20673483
FAS, FAS ligand, tumor infiltrating lymphocytes, and macrophages in malignant melanoma: an immunohistochemical study.
Bozdogan N, Bozdogan O, Pak I, Atasoy P
Int J Dermatol. 2010
PubMed ID: 20618494
Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
Ruaño G, Thompson PD, Kane JP, Pullinger CR, Windemuth A, Seip RL, Kocherla M, Holford TR, Wu AH
Pharmacogenomics. 2010
PubMed ID: 20602615
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.
Gómez-Sintes R, Lucas JJ
J Clin Invest. 2010
PubMed ID: 20530871
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Targeting immune privilege to prevent pathogenic neovascularization.
Roychoudhury J, Herndon JM, Yin J, Apte RS, Ferguson TA
Invest Ophthalmol Vis Sci. 2010
PubMed ID: 20164456
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Urbieta M, Barao I, Jones M, Jurecic R, Panoskaltsis-Mortari A, Blazar BR, Murphy WJ, Levy RB
Blood. 2010
PubMed ID: 20200356
Cell apoptosis and Fas gene expression in liver and renal tissues after ischemia-reperfusion injury in liver transplantation.
Li B, Chen B, Zhang G, Wang K, Zhou L, Hu S
Transplant Proc. 2010
PubMed ID: 20620473
FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
Lei D, Sturgis EM, Wang LE, Liu Z, Zafereo ME, Wei Q, Li G
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20501759
Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.
Wildbaum G, Zohar Y, Karin N
Am J Pathol. 2010
PubMed ID: 20382706
Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.
Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT
Hum Reprod. 2010
PubMed ID: 20378615
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
Bouchier-Hayes L, McBride S, van Geelen CM, Nance S, Lewis LK, Pinkoski MJ, Beere HM
Cell Death Differ. 2010
PubMed ID: 20150914
Foxo3a regulates apoptosis by negatively targeting miR-21.
Wang K, Li PF
J Biol Chem. 2010
PubMed ID: 20371612
NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects.
Olson JA, Leveson-Gower DB, Gill S, Baker J, Beilhack A, Negrin RS
Blood. 2010
PubMed ID: 20233969
Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.
Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC
J Clin Oncol. 2010
PubMed ID: 20385987
Fas and FasL Polymorphisms Are Not Associated with Acute Myeloid Leukemia Risk in Koreans.
Kim HJ, Jin XM, Kim HN, Lee IK, Park KS, Park MR, Jo DY, Won JH, Kwak JY, Kim HJ, Choi JS, Juhng SW, Choi C
DNA Cell Biol. 2010
PubMed ID: 20438363
FasL gene knock-down therapy enhances the antiglioma immune response.
Jansen T, Tyler B, Mankowski JL, Recinos VR, Pradilla G, Legnani F, Laterra J, Olivi A
Neuro Oncol. 2010
PubMed ID: 20406899
Dendritic cells and Stat3 are essential for CD137-induced CD8 T cell activation-induced cell death.
Zhang B, Zhang Y, Niu L, Vella AT, Mittler RS
J Immunol. 2010
PubMed ID: 20351189
Anaplastic plasmacytomas: relationships to normal memory B cells and plasma cell neoplasms of immunodeficient and autoimmune mice.
Qi CF, Shin DM, Li Z, Wang H, Feng J, Hartley JW, Fredrickson TN, Kovalchuk AL, Morse HC
J Pathol. 2010
PubMed ID: 20217872
Role of the Fas pathway in Pseudomonas aeruginosa keratitis.
Zhou Z, Wu M, Barrett RP, McClellan SA, Zhang Y, Hazlett LD
Invest Ophthalmol Vis Sci. 2010
PubMed ID: 20019368
TNF superfamily gene polymorphism as prognostic factor in early breast cancer.
Jung JH, Chae YS, Moon JH, Kang BW, Kim JG, Sohn SK, Park JY, Lee MH, Park HY
J Cancer Res Clin Oncol. 2010
PubMed ID: 19890662
Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice.
Sedger LM, Katewa A, Pettersen AK, Osvath SR, Farrell GC, Stewart GJ, Bendall LJ, Alexander SI
Blood. 2010
PubMed ID: 20185587
CD4(+)CD25(+) regulatory T cells utilize FasL as a mechanism to restrict DC priming functions in cutaneous immune responses.
Gorbachev AV, Fairchild RL
Eur J Immunol. 2010
PubMed ID: 20405474
Plasmacytoid dendritic cells enhance mortality during lethal influenza infections by eliminating virus-specific CD8 T cells.
Langlois RA, Legge KL
J Immunol. 2010
PubMed ID: 20220091
Underexpression and overexpression of Fas and Fas ligand: a double-edged sword.
Randhawa SR, Chahine BG, Lowery-Nordberg M, Cotelingam JD, Casillas AM
Ann Allergy Asthma Immunol. 2010
PubMed ID: 20408337
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Polymorphisms of FAS and FAS ligand genes and risk of skin cancer.
Qureshi A, Nan H, Dyer M, Han J
J Dermatol Sci. 2010
PubMed ID: 20219325
Multiple common variants for celiac disease influencing immune gene expression.
Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
Nat Genet. 2010
PubMed ID: 20190752
International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.
Truong T, Sauter W, McKay JD, Hosgood HD, Gallagher C, Amos CI, Spitz M, Muscat J, Lazarus P, Illig T, Wichmann HE, Bickeböller H, Risch A, Dienemann H, Zhang ZF, Naeim BP, Yang P, Zienolddiny S, Haugen A, Le Marchand L, Hong YC, Kim JH, Duell EJ, Andrew AS, Kiyohara C, Shen H, Matsuo K, Suzuki T, Seow A, Ng DP, Lan Q, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Constantinescu V, Bencko V, Foretova L, Janout V, Caporaso NE, Albanes D, Thun M, Landi MT, Trubicka J, Lener M, Lubinski J, EPIC-lung, Wang Y, Chabrier A, Boffetta P, Brennan P, Hung RJ
Carcinogenesis. 2010
PubMed ID: 20106900
FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis.
Lin YC, Yao PL, Richburg JH
Toxicol Sci. 2010
PubMed ID: 20100735
Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death.
Lafont E, Milhas D, Carpentier S, Garcia V, Jin ZX, Umehara H, Okazaki T, Schulze-Osthoff K, Levade T, Benoist H, Ségui B
Cell Death Differ. 2010
PubMed ID: 19779494
Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL.
Gangadharan C, Thoh M, Manna SK
Breast Cancer Res Treat. 2010
PubMed ID: 19649704
Adoptive transfer of mFas ligand into dendritic cells influences the spontaneous resorption rate in the CBA/J x DBA/2 mouse model.
Zhao A, Xiong M, Zhang Y, Bao S, Zhang J, Qiu L, Lin Q
Fertil Steril. 2010
PubMed ID: 19439286
Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues.
Li Q, Peng J, Li XH, Liu T, Liang QC, Zhang GY
World J Gastroenterol. 2010
PubMed ID: 20222173
Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer.
Knechtel G, Hofmann G, Gerger A, Renner W, Langsenlehner T, Szkandera J, Wolf G, Samonigg H, Krippl P, Langsenlehner U
J Cancer Res Clin Oncol. 2010
PubMed ID: 20204402
Acrolein induces apoptosis through the death receptor pathway in A549 lung cells: role of p53.
Roy J, Pallepati P, Bettaieb A, Averill-Bates DA
Can J Physiol Pharmacol. 2010
PubMed ID: 20393600
[Qingli shengjing pills decrease apoptosis of germ cells and expressions of fas and fasL in male mice infected with Escherichia coli]
Yu AL, Deng W, Jiao P, Shen JY, Zhu XM, Liu L, Zhuang DM
Zhonghua Nan Ke Xue. 2010
PubMed ID: 20369561
Correlation of Fas/FasL expression to cell apoptosis in Epstein-Barr virus-associated gastric carcinoma.
He D, Xiao L, Chen JN, Liang Q, Shao CK
Chin J Cancer. 2010
PubMed ID: 20193111
Polymorphisms in promoter region of FAS and FASL gene and risk of gastric cardiac adenocarcinoma.
Zhou RM, Wang N, Chen ZF, Duan YN, Sun DL, Li Y
J Gastroenterol Hepatol. 2010
PubMed ID: 20074157
Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death.
Vinken M, Decrock E, De Vuyst E, De Bock M, Vandenbroucke RE, De Geest BG, Demeester J, Sanders NN, Vanhaecke T, Leybaert L, Rogiers V
Cell Mol Life Sci. 2010
PubMed ID: 19960225
CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.
Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, Biglari B, Karray S, Martin-Villalba A
Immunity. 2010
PubMed ID: 20153221
Peroxynitrite-dependent killing of cancer cells and presentation of released tumor antigens by activated dendritic cells.
Fraszczak J, Trad M, Janikashvili N, Cathelin D, Lakomy D, Granci V, Morizot A, Audia S, Micheau O, Lagrost L, Katsanis E, Solary E, Larmonier N, Bonnotte B
J Immunol. 2010
PubMed ID: 20089706
Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population.
Wang LH, Ting SC, Chen CH, Tsai CC, Lung O, Liu TC, Lee CW, Wang YY, Tsai CL, Lin YC
J Oral Pathol Med. 2010
PubMed ID: 20359312
Expression of the Fas-ligand gene in ejaculated sperm from adolescents with and without varicocele.
Del Giudice PT, Lima SB, Cenedeze MA, Pacheco-Silva A, Bertolla RP, Cedenho AP
J Assist Reprod Genet. 2010
PubMed ID: 20165911
The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone.
Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC
Mol Endocrinol. 2010
PubMed ID: 20053716
Polymorphisms of FAS and FAS ligand genes in preeclamptic women.
Ciarmela P, Boschi S, Bloise E, Marozio L, Benedetto C, Castellucci M, Petraglia F
Eur J Obstet Gynecol Reprod Biol. 2010
PubMed ID: 19926197
Stored Fas ligand, a mediator of rapid CTL-mediated killing, has a lower threshold for response than degranulation or newly synthesized Fas ligand.
He JS, Gong DE, Ostergaard HL
J Immunol. 2010
PubMed ID: 19949069
Palmitoylation of human FasL modulates its cell death-inducing function.
Guardiola-Serrano F, Rossin A, Cahuzac N, Lückerath K, Melzer I, Mailfert S, Marguet D, Zörnig M, Hueber AO
Cell Death Dis. 2010
PubMed ID: 21368861
Differential levels of cytokines and soluble Fas ligand between tuberculous and malignant effusions.
Cui HY, Zhang Q, Su B, Li W, Tang SJ
J Int Med Res. 2010
PubMed ID: 21227011
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
Na IK, Lu SX, Yim NL, Goldberg GL, Tsai J, Rao U, Smith OM, King CG, Suh D, Hirschhorn-Cymerman D, Palomba L, Penack O, Holland AM, Jenq RR, Ghosh A, Tran H, Merghoub T, Liu C, Sempowski GD, Ventevogel M, Beauchemin N, van den Brink MR
J Clin Invest. 2010
PubMed ID: 19955659
Increased killing of liver NK cells by Fas/Fas ligand and NKG2D/NKG2D ligand contributes to hepatocyte necrosis in virus-induced liver failure.
Zou Y, Chen T, Han M, Wang H, Yan W, Song G, Wu Z, Wang X, Zhu C, Luo X, Ning Q
J Immunol. 2010
PubMed ID: 19949088
Taiwan cobra phospholipase A2-elicited JNK activation is responsible for autocrine fas-mediated cell death and modulating Bcl-2 and Bax protein expression in human leukemia K562 cells.
Chen KC, Liu WH, Chang LS
J Cell Biochem. 2010
PubMed ID: 19937732
Differential role of the Fas/Fas ligand apoptotic pathway in inflammation and lung fibrosis associated with reovirus 1/L-induced bronchiolitis obliterans organizing pneumonia and acute respiratory distress syndrome.
Lopez AD, Avasarala S, Grewal S, Murali AK, London L
J Immunol. 2009
PubMed ID: 20007588
IFN-gamma expressed by T cells regulates the persistence of antigen presentation by limiting the survival of dendritic cells.
Russell MS, Dudani R, Krishnan L, Sad S
J Immunol. 2009
PubMed ID: 19923462
Activated CD8+ T-effector/memory cells eliminate CD4+ CD25+ Foxp3+ T-suppressor cells from tumors via FasL mediated apoptosis.
Kilinc MO, Rowswell-Turner RB, Gu T, Virtuoso LP, Egilmez NK
J Immunol. 2009
PubMed ID: 19923444
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.
Varfolomeev E, Alicke B, Elliott JM, Zobel K, West K, Wong H, Scheer JM, Ashkenazi A, Gould SE, Fairbrother WJ, Vucic D
J Biol Chem. 2009
PubMed ID: 19854829
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
Protective role of Fas-FasL signaling in lethal infection with herpes simplex virus type 2 in mice.
Ishikawa T, Yamada H, Oyamada A, Goshima F, Nishiyama Y, Yoshikai Y
J Virol. 2009
PubMed ID: 19740996
The strength of the Fas ligand signal determines whether hepatocytes act as type 1 or type 2 cells in murine livers.
Schüngel S, Buitrago-Molina LE, Nalapareddy P, Lebofsky M, Manns MP, Jaeschke H, Gross A, Vogel A
Hepatology. 2009
PubMed ID: 19711425
The distribution and intracellular location of Fas and Fas Ligand following gastric carcinogenesis: Fas Ligand expressing gastric carcinoma cells can inhibit local immune response.
Liu H, Ubukata H, Tabuchi T, Nakachi T, Nagata H, Shimazaki J, Motohashi G, Konishi S, Nishimura M, Satani T, Hong J, Nakada I, Saniabadi AR, Tabuchi T
Mol Cell Biochem. 2009
PubMed ID: 19458913
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis.
O' Reilly LA, Tai L, Lee L, Kruse EA, Grabow S, Fairlie WD, Haynes NM, Tarlinton DM, Zhang JG, Belz GT, Smyth MJ, Bouillet P, Robb L, Strasser A
Nature. 2009
PubMed ID: 19794494
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Polymorphisms in cell death pathway genes are associated with altered sperm apoptosis and poor semen quality.
Ji G, Gu A, Hu F, Wang S, Liang J, Xia Y, Lu C, Song L, Fu G, Wang X
Hum Reprod. 2009
PubMed ID: 19542541
Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin.
Kim JG, Chae YS, Sohn SK, Moon JH, Ryoo HM, Bae SH, Kum Y, Jeon SW, Lim KH, Kang BM, Park IJ, Choi GS, Jun SH
Cancer Chemother Pharmacol. 2009
PubMed ID: 19219602
Expression of caspase family and muscle- and apoptosis-specific genes during skeletal myogenesis in mouse embryo.
Ikeda T, Kanazawa T, Otsuka S, Ichii O, Hashimoto Y, Kon Y
J Vet Med Sci. 2009
PubMed ID: 19801895
Membrane-bound Fas ligand requires RIP1 for efficient activation of caspase-8 within the death-inducing signaling complex.
Morgan MJ, Kim YS, Liu ZG
J Immunol. 2009
PubMed ID: 19641134
Peritumoral administration of granulocyte colony-stimulating factor induces an apoptotic response on a murine mammary adenocarcinoma.
Marino J, Furmento VA, Zotta E, Roguin LP
Cancer Biol Ther. 2009
PubMed ID: 19633419
Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.
Zhu JY, Giaisi M, Köhler R, Müller WW, Mühleisen A, Proksch P, Krammer PH, Li-Weber M
Cell Death Differ. 2009
PubMed ID: 19373244
Angiotensin II-inducible smooth muscle cell apoptosis involves the angiotensin II type 2 receptor, GATA-6 activation, and FasL-Fas engagement.
Tan NY, Li JM, Stocker R, Khachigian LM
Circ Res. 2009
PubMed ID: 19628789
Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity.
Shanker A, Brooks AD, Jacobsen KM, Wine JW, Wiltrout RH, Yagita H, Sayers TJ
Cancer Res. 2009
PubMed ID: 19654302
Cytotoxicity mediated by the Fas ligand (FasL)-activated apoptotic pathway in stem cells.
Mazar J, Thomas M, Bezrukov L, Chanturia A, Pekkurnaz G, Yin S, Kuznetsov SA, Robey PG, Zimmerberg J
J Biol Chem. 2009
PubMed ID: 19531476
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair.
Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A
Cell Stem Cell. 2009
PubMed ID: 19664992
Determination of the mechanism of action of anti-FasL antibody by epitope mapping and homology modeling.
Obungu VH, Gelfanova V, Rathnachalam R, Bailey A, Sloan-Lancaster J, Huang L
Biochemistry. 2009
PubMed ID: 19588926
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China.
Wang M, Wu D, Tan M, Gong W, Xue H, Shen H, Zhang Z
Biochem Genet. 2009
PubMed ID: 19565204
Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure.
Singhal S, Chakravarty A, Das BC, Kar P
Biomarkers. 2009
PubMed ID: 19505222
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
The -509C/T polymorphism of transforming growth factor-beta1 is associated with increased risk for development of chronic idiopathic neutropenia.
Eliopoulos DG, Mavroudi I, Pontikoglou C, Ximeri M, Stavroulaki E, Pyrovolaki K, Velegraki M, Spanoudakis M, Goulielmos G, Papadaki HA
Eur J Haematol. 2009
PubMed ID: 19614955
Expression of Fas/FasL in patients with oral lichen planus.
Hadzi-Mihailovic M, Raybaud H, Monteil R, Jankovic L
J BUON. 2009
PubMed ID: 19810143
Selective reduction of graft-versus-host disease-mediating human T cells by ex vivo treatment with soluble Fas ligand.
Bohana-Kashtan O, Morisot S, Hildreth R, Brayton C, Levitsky HI, Civin CI
J Immunol. 2009
PubMed ID: 19535642
A new function of the Fas-FasL pathway in macrophage activation.
Chakour R, Allenbach C, Desgranges F, Charmoy M, Mauel J, Garcia I, Launois P, Louis J, Tacchini-Cottier F
J Leukoc Biol. 2009
PubMed ID: 19380712
NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses.
Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K
Blood. 2009
PubMed ID: 19406986
Expression of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 during sertoli cell infection by ureaplasma urealyticum.
Li R, Xi Y, Liu X, Chen G, Wang B, Jiang L, Li W
Cell Mol Immunol. 2009
PubMed ID: 19567205
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.
Juric V, Chen CC, Lau LF
Mol Cell Biol. 2009
PubMed ID: 19364818
Serum sFas and tumor tissue FasL negatively correlated with survival in Egyptian patients suffering from breast ductal carcinoma.
El-Sarha AI, Magour GM, Zaki SM, El-Sammak MY
Pathol Oncol Res. 2009
PubMed ID: 19015953
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Effect of FasL gene expression on proliferation and apoptosis of rectal carcinoma cells in hypoxia state]
Zhao F, Li SY, An P, Yu B, Cai HY
Zhonghua Wei Chang Wai Ke Za Zhi. 2009
PubMed ID: 19434529
FasL cross-linking inhibits activation of human peripheral T cells.
Paulsen M, Mathew B, Qian J, Lettau M, Kabelitz D, Janssen O
Int Immunol. 2009
PubMed ID: 19332441
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
FASLG polymorphism is associated with cancer risk.
Liu Y, Wen QJ, Yin Y, Lu XT, Pu SH, Tian HP, Lou YF, Tang YN, Jiang X, Lu GS, Zhang J
Eur J Cancer. 2009
PubMed ID: 19403301
Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
Cai CF, Feng L, Wang L, Kong QZ, Zhao YF
Arch Pharm Res. 2009
PubMed ID: 19407976
Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye.
Montalvo V, Gery I
Curr Eye Res. 2009
PubMed ID: 19373582
The FAS ligand promoter polymorphism, rs763110 (-844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies.
Zhang Z, Qiu L, Wang M, Tong N, Li J, Zhang Z
Eur J Hum Genet. 2009
PubMed ID: 19337311
Expression of Fas and Fas ligand in human testicular germ cell tumours.
Baldini E, Ulisse S, Marchioni E, Di Benedetto A, Giovannetti G, Petrangeli E, Sentinelli S, Donnorso RP, Reale MG, Mottolese M, Gandini L, Lenzi A, D'Armiento M
Int J Androl. 2009
PubMed ID: 17916181
FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function.
Magerus-Chatinet A, Stolzenberg MC, Loffredo MS, Neven B, Schaffner C, Ducrot N, Arkwright PD, Bader-Meunier B, Barbot J, Blanche S, Casanova JL, Debré M, Ferster A, Fieschi C, Florkin B, Galambrun C, Hermine O, Lambotte O, Solary E, Thomas C, Le Deist F, Picard C, Fischer A, Rieux-Laucat F
Blood. 2009
PubMed ID: 19176318
Genetic variants in the candidate genes of the apoptosis pathway and susceptibility to chronic myeloid leukemia.
Kim DH, Xu W, Ma C, Liu X, Siminovitch K, Messner HA, Lipton JH
Blood. 2009
PubMed ID: 19141860
[Effect of resveratrol-induced FasL up-regulation on the apoptosis of pancreatic acinar cells in rats with severe acute pancreatitis]
Li ZD, Ma QY, Luo YH
Nan Fang Yi Ke Da Xue Xue Bao. 2009
PubMed ID: 19304523
Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer.
Park JY, Lee WK, Jung DK, Choi JE, Park TI, Lee EB, Cho S, Park JY, Cha SI, Kim CH, Kam S, Jung TH, Jheon S
Clin Cancer Res. 2009
PubMed ID: 19240174
Fas ligand is required for the development of respiratory syncytial virus vaccine-enhanced disease.
Olson MR, Varga SM
J Immunol. 2009
PubMed ID: 19234198
Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE: a possible explanation for the lack of efficacy of hrDNase I treatment.
Tinazzi E, Puccetti A, Gerli R, Rigo A, Migliorini P, Simeoni S, Beri R, Dolcino M, Martinelli N, Corrocher R, Lunardi C
Int Immunol. 2009
PubMed ID: 19181929
Cardiac-targeted expression of soluble fas attenuates doxorubicin-induced cardiotoxicity in mice.
Niu J, Azfer A, Wang K, Wang X, Kolattukudy PE
J Pharmacol Exp Ther. 2009
PubMed ID: 19066339
The many roles of FAS receptor signaling in the immune system.
Strasser A, Jost PJ, Nagata S
Immunity. 2009
PubMed ID: 19239902
A non-apoptotic role for Fas/FasL in erythropoiesis.
Carlile GW, Smith DH, Wiedmann M
FEBS Lett. 2009
PubMed ID: 19244619
Involvement of the intrinsic and extrinsic cell-death pathways in the induction of apoptosis of mature lymphocytes by the Escherichia coli heat-labile enterotoxin.
Tamayo E, Postigo J, Del Giudice G, Rappuoli R, Benito A, Yagita H, Merino R, Merino J
Eur J Immunol. 2009
PubMed ID: 19180465
Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis.
Strauss L, Bergmann C, Whiteside TL
J Immunol. 2009
PubMed ID: 19155494
Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes.
Linkermann A, Gelhaus C, Lettau M, Qian J, Kabelitz D, Janssen O
Biochim Biophys Acta. 2009
PubMed ID: 19041431
Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
Am J Obstet Gynecol. 2009
PubMed ID: 19019335
Thy1 up-regulates FasL expression in lung myofibroblasts via Src family kinases.
Cohen PY, Breuer R, Wallach-Dayan SB
Am J Respir Cell Mol Biol. 2009
PubMed ID: 18676775
Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells.
Bonofiglio D, Gabriele S, Aquila S, Qi H, Belmonte M, Catalano S, Andò S
Breast Cancer Res Treat. 2009
PubMed ID: 18293083
A possible role of Fas-ligand-mediated "reverse signaling" in pathogenesis of rheumatoid arthritis and systemic lupus erythematosus.
Telegina E, Reshetnyak T, Moshnikova A, Proussakova O, Zhukova A, Kuznetsova A, Ivanov A, Paltsev M, Beletsky I
Immunol Lett. 2009
PubMed ID: 19010354
Infliximab Dependency in Children with Crohn's Disease.
Duricova D, Pedersen N, Lenicek M, Hradsky O, Bronsky J, Adamcova M, Elkjaer M, Andersen PS, Vitek L, Larsen K, Lukas M, Nevoral J, Wewer V, Munkholm P
Aliment Pharmacol Ther. 2009
PubMed ID: 19183163
Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans.
Chatterjee K, Engelmark M, Gyllensten U, Dandara C, van der Merwe L, Galal U, Hoffman M, Williamson AL
BMC Res Notes. 2009
PubMed ID: 19941645
Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
Voss M, Lettau M, Janssen O
BMC Immunol. 2009
PubMed ID: 19807924
Interleukin-10 overexpression promotes Fas-ligand-dependent chronic macrophage-mediated demyelinating polyneuropathy.
Dace DS, Khan AA, Stark JL, Kelly J, Cross AH, Apte RS
PLoS One. 2009
PubMed ID: 19771172
Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.
Lundy SK, Fox DA
Arthritis Res Ther. 2009
PubMed ID: 19706160
Helicobacter pylori increases expression of proapoptotic markers Fas and FasL on CD4 lymphocytes in children.
Kotłowska-Kmieć A, Bakowska A, Szarszewski A, Kamińska B, Łuczak G, Radys W, Landowski P, Brodzicki J, Korzon M, Liberek A
Acta Biochim Pol. 2009
PubMed ID: 19572057
[Association between Fas/Fas L genes promoter polymorphisms and pathogenic risk of cervical cancer]
Li H, Guo HY, Sun T, Zhou YF, Lin DX, Zhang WH, Qiao J
Zhonghua Zhong Liu Za Zhi. 2009
PubMed ID: 19538867
If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
Reprod Biol Endocrinol. 2009
PubMed ID: 19527514
Lung cancer susceptibility model based on age, family history and genetic variants.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
PLoS One. 2009
PubMed ID: 19390575
Expressions of Fas/DcR3 and RGD-FasL mediated apoptosis in pituitary adenomas.
Chen L, Tian X, Li W, Agarwal A, Zhuang G
Neurol India. 2009
PubMed ID: 19305072
The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin.
Almendro V, Ametller E, García-Recio S, Collazo O, Casas I, Augé JM, Maurel J, Gascón P
PLoS One. 2009
PubMed ID: 19266094
FAS and FASLG polymorphisms and susceptibility to idiopathic azoospermia or severe oligozoospermia.
Wang W, Lu N, Xia Y, Gu A, Wu B, Liang J, Zhang W, Wang Z, Su J, Wang X
Reprod Biomed Online. 2009
PubMed ID: 19146781
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124506
NKG2A inhibits invariant NKT cell activation in hepatic injury.
Kawamura T, Takeda K, Kaneda H, Matsumoto H, Hayakawa Y, Raulet DH, Ikarashi Y, Kronenberg M, Yagita H, Kinoshita K, Abo T, Okumura K, Smyth MJ
J Immunol. 2009
PubMed ID: 19109156
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S
J Clin Invest. 2009
PubMed ID: 19104149
Distinct requirements for activation-induced cell surface expression of preformed Fas/CD95 ligand and cytolytic granule markers in T cells.
Kassahn D, Nachbur U, Conus S, Micheau O, Schneider P, Simon HU, Brunner T
Cell Death Differ. 2009
PubMed ID: 19079288
SBDS-deficiency results in specific hypersensitivity to Fas stimulation and accumulation of Fas at the plasma membrane.
Watanabe K, Ambekar C, Wang H, Ciccolini A, Schimmer AD, Dror Y
Apoptosis. 2009
PubMed ID: 19009351
Age-dependent, polyclonal hyperactivation of T cells is reduced in TNF-negative gld/gld mice.
Wiede F, Roomberg A, Cretney E, Lechner A, Fromm P, Wren L, Smyth MJ, Körner H
J Leukoc Biol. 2009
PubMed ID: 18948547
Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production.
Dakhova O, O'Day D, Kinet N, Yucer N, Wiese M, Shetty G, Ducy P
Endocrinology. 2009
PubMed ID: 18818293
Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo.
Woodworth JS, Wu Y, Behar SM
J Immunol. 2008
PubMed ID: 19050279
TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin.
Kim JG, Sohn SK, Chae YS, Song HS, Kwon KY, Do YR, Kim MK, Lee KH, Hyun MS, Lee WS, Sohn CH, Jung JS, Kim GC, Chung HY, Yu W
Cancer Chemother Pharmacol. 2008
PubMed ID: 19052714
Prevention of autoimmunity and control of recall response to exogenous antigen by Fas death receptor ligand expression on T cells.
Mabrouk I, Buart S, Hasmim M, Michiels C, Connault E, Opolon P, Chiocchia G, Lévi-Strauss M, Chouaib S, Karray S
Immunity. 2008
PubMed ID: 19013083
Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes.
Walter D, Schmich K, Vogel S, Pick R, Kaufmann T, Hochmuth FC, Haber A, Neubert K, McNelly S, von Weizsäcker F, Merfort I, Maurer U, Strasser A, Borner C
Hepatology. 2008
PubMed ID: 19003879
Hepatocellular apoptosis is mediated by TNFalpha-dependent Fas/FasLigand cytotoxicity in a murine model of acute liver failure.
Kuhla A, Eipel C, Siebert N, Abshagen K, Menger MD, Vollmar B
Apoptosis. 2008
PubMed ID: 18946736
TLR4/MYD88-dependent, LPS-induced synthesis of PGE2 by macrophages or dendritic cells prevents anti-CD3-mediated CD95L upregulation in T cells.
Weinlich R, Bortoluci KR, Chehab CF, Serezani CH, Ulbrich AG, Peters-Golden M, Russo M, Amarante-Mendes GP
Cell Death Differ. 2008
PubMed ID: 18820644
Ferritin and FasL (CD95L) mediate density dependent apoptosis in primary rat hepatocytes.
Bresgen N, Ohlenschläger I, Wacht N, Afazel S, Ladurner G, Eckl PM
J Cell Physiol. 2008
PubMed ID: 18726999
c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells.
Waetzig V, Loose K, Haeusgen W, Herdegen T
Biochem Pharmacol. 2008
PubMed ID: 18692025
The Fas system confers protection against alveolar disruption in hyperoxia-exposed newborn mice.
Mao Q, Gundavarapu S, Patel C, Tsai A, Luks FI, De Paepe ME
Am J Respir Cell Mol Biol. 2008
PubMed ID: 18587053
Soluble Fas ligand plasma levels are associated with forearm reactive hyperemia in subjects with coronary artery disease: a novel biomarker of endothelial function?
Blanco-Colio LM, Martín-Ventura JL, Tuñón J, García-Camarero T, Berrazueta JR, Egido J
Atherosclerosis. 2008
PubMed ID: 18359029
Dissection of effector pathways in the host-versus-graft response to bone marrow transplantation.
Weng L, Addey C, Warrens AN, Dyson J, Chai JG, Dazzi F
Transplantation. 2008
PubMed ID: 19005414
The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells.
Thornhill PB, Cohn JB, Stanford WL, Desbarats J
Biochem Biophys Res Commun. 2008
PubMed ID: 18789888
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand.
Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ
J Neurosci. 2008
PubMed ID: 19005073
[The change of certain biochemical indexes and apotosis protein (Fas/FasL) expression in rat liver of selenium and iodine deficiency].
Zhang D, Lei Y, Zhao J, Tan W
Wei Sheng Yan Jiu. 2008
PubMed ID: 19239001
Distinct but complementary roles of Fas ligand and Bim in homeostatic T cell apoptosis.
Kassahn D, Brunner T, Corazza N
Cell Cycle. 2008
PubMed ID: 18971628
Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
Wu X, Lu C, Ye Y, Chang J, Yang H, Lin J, Gu J, Hong WK, Stewart D, Spitz MR
Pharmacogenet Genomics. 2008
PubMed ID: 18854777
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis.
Bajou K, Peng H, Laug WE, Maillard C, Noel A, Foidart JM, Martial JA, DeClerck YA
Cancer Cell. 2008
PubMed ID: 18835034
Evaluation of apoptotic cells and immunohistochemical detection of FAS, FAS-L, Bcl-2, Bax, p53 and c-Myc in the skin of patients with chronic venous leg ulcers.
Heising S, Giebel J, Ostrowitzki AL, Riedel F, Haase H, Sippel K, Jünger M
Int J Mol Med. 2008
PubMed ID: 18813857
Autoreactive B-cell elimination by pathogenic IgG specific for the same antigen: implications for peripheral tolerance.
Ota T, Aoki-Ota M, Tsunoda K, Nishikawa T, Koyasu S, Amagai M
Int Immunol. 2008
PubMed ID: 18765425
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.
Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue J, Akiyama T, Takahama Y
Immunity. 2008
PubMed ID: 18799150
Neutrophil-dependent tumor rejection and priming of tumoricidal CD8+ T cell response induced by dendritic cells overexpressing CD95L.
Buonocore S, Haddou NO, Moore F, Florquin S, Paulart F, Heirman C, Thielemans K, Goldman M, Flamand V
J Leukoc Biol. 2008
PubMed ID: 18567840
Skewing the Th cell phenotype toward Th1 alters the maturation of tumor-infiltrating mononuclear phagocytes.
Nonaka K, Saio M, Suwa T, Frey AB, Umemura N, Imai H, Ouyang GF, Osada S, Balazs M, Adany R, Kawaguchi Y, Yoshida K, Takami T
J Leukoc Biol. 2008
PubMed ID: 18566103
Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.
Ter-Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, Heist RS, Lynch TJ, Wain JC, Lin X, Devivo I, Christiani DC
Carcinogenesis. 2008
PubMed ID: 18757527
Restricted Semliki Forest virus replication in perforin and Fas-ligand double-deficient mice.
Alsharifi M, Lobigs M, Bettadapura J, Koskinen A, Müllbacher A
J Gen Virol. 2008
PubMed ID: 18632965
Elevated Fas expression is related to increased apoptosis of circulating CD8+ T cell in patients with gastric cancer.
Yoshikawa T, Saito H, Osaki T, Matsumoto S, Tsujitani S, Ikeguchi M
J Surg Res. 2008
PubMed ID: 18561948
Blockade of the Fas/Fas ligand interaction suppresses hepatocyte apoptosis in ischemia-reperfusion rat liver.
Nakajima H, Mizuta N, Fujiwara I, Sakaguchi K, Ogata H, Magae J, Yagita H, Koji T
Apoptosis. 2008
PubMed ID: 18561025
Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells.
Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I
Blood. 2008
PubMed ID: 18509086
Improved secretion of human Fas ligand extracellular domain by N-terminal part truncation in Pichia pastoris and preparation of the N-linked carbohydrate chain trimmed derivative.
Muraki M
Protein Expr Purif. 2008
PubMed ID: 18501631
Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes.
Bosque A, Aguiló JI, del Rey M, Paz-Artal E, Allende LM, Naval J, Anel A
J Leukoc Biol. 2008
PubMed ID: 18483205
Genetic Polymorphisms of IL-1A, IL-1B, IL-1RN, NFKB1, FAS, and FASL, and Risk of Silicosis in a Chinese Occupational Population.
Wu F, Xia Z, Qu Y, Tang Y, Cao D, Sun P, Christiani DC
Am J Ind Med. 2008
PubMed ID: 18666137
Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome.
Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S
Br J Ophthalmol. 2008
PubMed ID: 18577653
Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma.
Zhang Y, Xu G, Zhang L, Roberts AI, Shi Y
J Immunol. 2008
PubMed ID: 18566384
Evaluation of angiopoietins and cell-derived microparticles after stem cell transplantation.
Nomura S, Ishii K, Inami N, Kimura Y, Uoshima N, Ishida H, Yoshihara T, Urase F, Maeda Y, Hayashi K
Biol Blood Marrow Transplant. 2008
PubMed ID: 18541195
Effect of tumour necrosis factor-alpha receptor 1 genetic deletion on carrageenan-induced acute inflammation: a comparison with etanercept.
Mazzon E, Esposito E, Di Paola R, Muià C, Crisafulli C, Genovese T, Caminiti R, Meli R, Bramanti P, Cuzzocrea S
Clin Exp Immunol. 2008
PubMed ID: 18505433
Fas/FasL-dependent apoptosis of hepatocytes induced in rat and patients with Clonorchis sinensis infection.
Zhang X, Jin Z, Da R, Dong Y, Song W, Chen X, Huang Q, Ling H, Che Y, Li Y, Zhang F
Parasitol Res. 2008
PubMed ID: 18427836
Placental fas/fas ligand expression in early pregnancy losses.
Guvendag Guven ES, Okur H, Beksac MS
Am J Reprod Immunol. 2008
PubMed ID: 18422813
FasL shedding is reduced by hypothermia in experimental stroke.
Liu L, Kim JY, Koike MA, Yoon YJ, Tang XN, Ma H, Lee H, Steinberg GK, Lee JE, Yenari MA
J Neurochem. 2008
PubMed ID: 18410517
Transient local depletion of Foxp3(+) regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death.
Reardon C, Wang A, McKay DM
J Immunol. 2008
PubMed ID: 18523298
Functional Polymorphisms of the FAS Gene Associated with Risk of Vitiligo in Chinese Populations: A Case-Control Analysis.
Li M, Sun D, Li C, Zhang Z, Gao L, Li K, Li H, Gao T
J Invest Dermatol. 2008
PubMed ID: 18548110
[Apoptosis of active T lymphocytes induced by human laryngocarcinoma cell line].
Ye J, Zhang G, Liu X, Yang Q, Li P, Huang J, Li Y
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008
PubMed ID: 18800686
Utility of antiPax5 in the diagnosis of lymphoproliferative disorders and neoplasia in mice.
Rehg JE, Sundberg JP
Comp Med. 2008
PubMed ID: 18589866
Differential expression of Fas system apoptotic molecules in peripheral lymphocytes from patients with Graves' disease and Hashimoto's thyroiditis.
Fountoulakis S, Vartholomatos G, Kolaitis N, Frillingos S, Philippou G, Tsatsoulis A
Eur J Endocrinol. 2008
PubMed ID: 18505906
p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice.
Shetty G, Shao SH, Weng CC
Endocrinology. 2008
PubMed ID: 18356279
Functional variants in cell death pathway genes and risk of pancreatic cancer.
Yang M, Sun T, Wang L, Yu D, Zhang X, Miao X, Liu J, Zhao D, Li H, Tan W, Lin D
Clin Cancer Res. 2008
PubMed ID: 18483392
Relationship between expression of gastrin, somatostatin, Fas/FasL and caspases in large intestinal carcinoma.
Mao JD, Wu P, Yang YL, Wu J, Huang H
World J Gastroenterol. 2008
PubMed ID: 18473402
[Fas-FasL and caspase-3 signal transduction pathway and apoptosis of peripheral T lymphocytes in ITP patients]
Zhong YG, Feng WY, Luo HQ, Fu JP, Jin J
Zhonghua Xue Ye Xue Za Zhi. 2008
PubMed ID: 18844072
CD95 ligand is a proliferative and antiapoptotic signal in quiescent hepatic stellate cells.
Reinehr R, Sommerfeld A, Häussinger D
Gastroenterology. 2008
PubMed ID: 18471522
A novel molecular mechanism for anticancer drug-induced ovarian failure: Irinotecan HCl, an anticancer topoisomerase I inhibitor, induces specific FasL expression in granulosa cells of large ovarian follicles to enhance follicular apoptosis.
Utsunomiya T, Tanaka T, Utsunomiya H, Umesaki N
Int J Oncol. 2008
PubMed ID: 18425325
Coelomic cells show apoptosis via Fas/FasL system: a comparative study between healthy human pregnancies and missed miscarriages.
Kaponis A, Skyrlas A, Zagorianakou N, Georgiou I, Passa V, Paraskevaidis E, Makrydimas G
Hum Reprod. 2008
PubMed ID: 18316328
Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression.
Contassot E, Kerl K, Roques S, Shane R, Gaide O, Dupuis M, Rook AH, French LE
Blood. 2008
PubMed ID: 18314443
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Fas ligand expression on human nucleus pulposus cells decreases with disc degeneration processes.
Kaneyama S, Nishida K, Takada T, Suzuki T, Shimomura T, Maeno K, Kurosaka M, Doita M
J Orthop Sci. 2008
PubMed ID: 18392917
Identification of apoptotic proteins in thyroid gland from patients with Graves' disease and Hashimoto's thyroiditis.
Bossowski A, Czarnocka B, Bardadin K, Stasiak-Barmuta A, Urban M, Dadan J, Ratomski K, Bossowska A
Autoimmunity. 2008
PubMed ID: 18324486
The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation.
Wang L, Azad N, Kongkaneramit L, Chen F, Lu Y, Jiang BH, Rojanasakul Y
J Immunol. 2008
PubMed ID: 18292530
Mutation in the Fas Pathway Impairs CD8+ T Cell Memory.
Dudani R, Russell M, van Faassen H, Krishnan L, Sad S
J Immunol. 2008
PubMed ID: 18292515
Calmodulin binding to the Fas-mediated death-inducing signaling complex in cholangiocarcinoma cells.
Chen Y, Pawar P, Pan G, Ma L, Liu H, McDonald JM
J Cell Biochem. 2008
PubMed ID: 17654480
Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival.
Krum SA, Miranda-Carboni GA, Hauschka PV, Carroll JS, Lane TF, Freedman LP, Brown M
EMBO J. 2008
PubMed ID: 18219273
Evaluation of functional single nucleotide polymorphisms of different genes coding for the immunoregulatory molecules in patients with monoclonal large granular lymphocyte lymphocytosis.
Garrido P, Almeida J, Romero JM, Cantón J, Sandberg Y, Bárcena P, Lima M, Langerak AW, Orfao A, Ruiz-Cabello F
Hum Immunol. 2008
PubMed ID: 18361934
No requirement for TRAIL in intrathymic negative selection.
Cretney E, Uldrich AP, McNab FW, Godfrey DI, Smyth MJ
Int Immunol. 2008
PubMed ID: 18192669
Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
Rheumatology (Oxford). 2008
PubMed ID: 18174230
Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosis.
Thorpe JA, Christian PA, Schwarze SR
Prostate. 2008
PubMed ID: 18076022
The sodium-dependent glucose cotransporter SLC5A11 as an autoimmune modifier gene in SLE.
Tsai LJ, Hsiao SH, Tsai LM, Lin CY, Tsai JJ, Liou DM, Lan JL
Tissue Antigens. 2008
PubMed ID: 18069935
The "Fas counterattack" is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability.
Houston AM, Michael-Robinson JM, Walsh MD, Cummings MC, Ryan AE, Lincoln D, Pandeya N, Jass JR, Radford-Smith GL, O'Connell J
Hum Pathol. 2008
PubMed ID: 17961631
Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligand-mediated apoptotic pathway in human non-small cell lung cancer A549 cells.
Hung JY, Yang CJ, Tsai YM, Huang HW, Huang MS
Clin Exp Pharmacol Physiol. 2008
PubMed ID: 17941899
Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.
Reinehr R, Sommerfeld A, Keitel V, Grether-Beck S, Haüssinger D
J Biol Chem. 2008
PubMed ID: 18045865
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis.
Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, Smyth MJ
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18178624
Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
PLoS ONE. 2008
PubMed ID: 18818748
Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions.
Hsu PI, Lu PJ, Wang EM, Ger LP, Lo GH, Tsay FW, Chen TA, Yang HB, Chen HC, Lin WS, Lai KH
Anticancer Res. 2008
PubMed ID: 18383830
[Polymorphisms of FAS and FASL genes and susceptibility of silicosis]
Wu F, Qu YB, Sun P, Ji F, Qiu YL, Miao WB, Wang W, Jin RF, Xia ZL
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008
PubMed ID: 18302883
Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli.
Wisniewski P, Master A, Kaminska B
Acta Biochim Pol. 2008
PubMed ID: 18204739
FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer.
Kang S, Dong SM, Seo SS, Kim JW, Park SY
Cancer Genet Cytogenet. 2008
PubMed ID: 18068525
Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma.
Lerma E, Romero M, Gallardo A, Pons C, Muñoz J, Fuentes J, Lloveras B, Catasus L, Prat J
Virchows Arch. 2008
PubMed ID: 18000680
Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis.
Wallach-Dayan SB, Golan-Gerstl R, Breuer R
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18077384
Increased apoptosis of peripheral blood lymphocytes and its association with interleukin-18 in patients with active untreated adult-onset Still's disease.
Chen DY, Hsieh TY, Hsieh CW, Lin FJ, Lan JL
Arthritis Rheum. 2007
PubMed ID: 18050226
Preemptive HMG-CoA reductase inhibition provides graft-versus-host disease protection by Th-2 polarization while sparing graft-versus-leukemia activity.
Zeiser R, Youssef S, Baker J, Kambham N, Steinman L, Negrin RS
Blood. 2007
PubMed ID: 17827390
Expression of CD95 and CD95L on astrocytes in the CA1 area of the immature rat hippocampus after hypoxia-ischemia injury.
Kim MJ, Lim HS, Yoo YB, Lee YI, Hahm DH, Lee HJ, Jung KW, Kim JW, Yoe SM, Chung DC, Chang YP
Comp Med. 2007
PubMed ID: 18246871
Statins stimulate in vitro membrane FasL expression and lymphocyte apoptosis through RhoA/ROCK pathway in murine melanoma cells.
Sarrabayrouse G, Synaeve C, Leveque K, Favre G, Tilkin-Mariamé AF
Neoplasia. 2007
PubMed ID: 18084615
Aqueous humor levels of soluble Fas and Fas-ligand in patients with primary open angle and pseudoexfoliation glaucoma.
Razeghinejad MR, Kamali-Sarvestani E
Iran J Immunol. 2007
PubMed ID: 18057579
Suppression of FasL expression in tumor cells and preventing tumor necrosis factor-induced apoptosis by adenovirus 14.7K is an effective escape mechanism for immune cells.
Zhang J, Xu G
Cancer Genet Cytogenet. 2007
PubMed ID: 18036397
Transgenic expression of Bcl-xL or Bcl-2 by murine B cells enhances the in vivo antipolysaccharide, but not antiprotein, response to intact Streptococcus pneumoniae.
Chattopadhyay G, Khan AQ, Sen G, Colino J, DuBois W, Rubtsov A, Torres RM, Potter M, Snapper CM
J Immunol. 2007
PubMed ID: 18025197
Donor double-negative Treg promote allogeneic mixed chimerism and tolerance.
He KM, Ma Y, Wang S, Min WP, Zhong R, Jevnikar A, Zhang ZX
Eur J Immunol. 2007
PubMed ID: 18000953
Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk.
Crew KD, Gammon MD, Terry MB, Zhang FF, Agrawal M, Eng SM, Sagiv SK, Teitelbaum SL, Neugut AI, Santella RM
Carcinogenesis. 2007
PubMed ID: 17962219
Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression.
Koide N, Morikawa A, Tumurkhuu G, Dagvadorj J, Hassan F, Islam S, Naiki Y, Mori I, Yoshida T, Yokochi T
Clin Exp Immunol. 2007
PubMed ID: 17900305
Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis.
Peng Y, Sigua CA, Karsonovich C, Murr MM
J Gastrointest Surg. 2007
PubMed ID: 17899301
Involvement of cellular death in TRAIL/DR5-dependent suppression induced by CD4(+)CD25(+) regulatory T cells.
Ren X, Ye F, Jiang Z, Chu Y, Xiong S, Wang Y
Cell Death Differ. 2007
PubMed ID: 17762882
Enforced covalent trimerization increases the activity of the TNF ligand family members TRAIL and CD95L.
Berg D, Lehne M, Müller N, Siegmund D, Münkel S, Sebald W, Pfizenmaier K, Wajant H
Cell Death Differ. 2007
PubMed ID: 17703232
Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer.
Ivansson EL, Gustavsson IM, Magnusson JJ, Steiner LL, Magnusson PK, Erlich HA, Gyllensten UB
Int J Cancer. 2007
PubMed ID: 17688234
Antigen-presenting cell population dynamics during murine silicosis.
Beamer CA, Holian A
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17641296
Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease.
Pan J, Zhao YX, Wang ZQ, Jin L, Sun ZK, Chen SD
Neurosci Lett. 2007
PubMed ID: 17959308
Down-regulation of Fas-ligand mRNA in Sjögren's syndrome patients with enlarged exocrine glands.
Tsuzaka K, Matsumoto Y, Sasaki Y, Abe T, Tsubota K, Takeuchi T
Autoimmunity. 2007
PubMed ID: 17966039
TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.
Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P
J Immunol. 2007
PubMed ID: 17947688
Cutting edge: two distinct motifs within the Fas ligand tail regulate Fas ligand-mediated costimulation.
Sun M, Lee S, Karray S, Levi-Strauss M, Ames KT, Fink PJ
J Immunol. 2007
PubMed ID: 17947633
Apoptosis in the kidneys of patients with type II diabetic nephropathy.
Verzola D, Gandolfo MT, Ferrario F, Rastaldi MP, Villaggio B, Gianiorio F, Giannoni M, Rimoldi L, Lauria F, Miji M, Deferrari G, Garibotto G
Kidney Int. 2007
PubMed ID: 17851466
FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts.
Miyagawa-Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H, Okuno T, Toyokuni S, Tamaki K, Yamabe H, Manabe T, Uemoto S
Am J Pathol. 2007
PubMed ID: 17823283
Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system.
Shrestha B, Diamond MS
J Virol. 2007
PubMed ID: 17804505
Association of human leukocyte antigen and T cell message with human papillomavirus 16-positive cervical neoplasia in Japanese women.
Saito M, Okubo M, Hirata R, Takeda S, Maeda H
Int J Gynecol Cancer. 2007
PubMed ID: 17433060
The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells.
Kim KW, Ha KY, Lee JS, Rhyu KW, An HS, Woo YK
Spine (Phila Pa 1976). 2007
PubMed ID: 18090083
Expression and distribution of S-100 protein, CD83 and apoptosis-related proteins (Fas, FasL and Bcl-2) in thyroid tissues of autoimmune thyroid diseases.
Xu WC, Chen SR, Huang JX, Zheng ZC, Chen LX, Lin JJ, Li YG
Eur J Histochem. 2007
PubMed ID: 18162459
Expression of proliferative and preapoptotic molecules in human myometrium and leiomyoma throughout the menstrual cycle.
Kayisli UA, Berkkanoglu M, Kizilay G, Senturk L, Arici A
Reprod Sci. 2007
PubMed ID: 18000229
Expression of Fas and Fas-ligand in donor hematopoietic stem and progenitor cells is dissociated from the sensitivity to apoptosis.
Pearl-Yafe M, Yolcu ES, Stein J, Kaplan O, Shirwan H, Yaniv I, Askenasy N
Exp Hematol. 2007
PubMed ID: 17889725
Fas/FasL-mediated apoptosis in the arcuate nucleus and medial preoptic area of male ArKO mice is ameliorated by selective estrogen receptor alpha and estrogen receptor beta agonist treatment, respectively.
Hill RA, Chow J, Fritzemeier K, Simpson ER, Boon WC
Mol Cell Neurosci. 2007
PubMed ID: 17716913
Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression.
Bhuiyan MS, Shibuya M, Shioda N, Moriguchi S, Kasahara J, Iwabuchi Y, Fukunaga K
Eur J Pharmacol. 2007
PubMed ID: 17658509
Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.
Brunlid G, Pruszak J, Holmes B, Isacson O, Sonntag KC
Stem Cells. 2007
PubMed ID: 17615270
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.
Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S
Cell. 2007
PubMed ID: 17803905
Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation.
Minas V, Rolaki A, Kalantaridou SN, Sidiropoulos J, Mitrou S, Petsas G, Jeschke U, Paraskevaidis EA, Fountzilas G, Chrousos GP, Pavlidis N, Makrigiannakis A
Br J Cancer. 2007
PubMed ID: 17667919
Soluble Fas and soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis: a Tunisian case-control study.
Mrabet D, Hajri R, Hamzaoui K, Attia Romdhane N, Zakraoui L
Clin Exp Rheumatol. 2007
PubMed ID: 18078642
[Relationship between FAS/FASL gene polymorphisms and susceptibility of coal worker's pneumoconiosis]
Ni CH, Song ZF, Jia XM, Li AP, Li CP, Li SK, Li YM, Wang ZL, Zhou Y, Wang SY, Zhang ZD, Zhou JW
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2007
PubMed ID: 17997887
Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin.
Minas V, Jeschke U, Kalantaridou SN, Richter DU, Reimer T, Mylonas I, Friese K, Makrigiannakis A
Mol Hum Reprod. 2007
PubMed ID: 17704118
A biochemical mechanism for resistance of intervertebral discs to metastatic cancer: Fas ligand produced by disc cells induces apoptotic cell death of cancer cells.
Park JB, Lee JK, Cho ST, Park EY, Riew KD
Eur Spine J. 2007
PubMed ID: 17684774
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells.
Kirkin V, Cahuzac N, Guardiola-Serrano F, Huault S, Lückerath K, Friedmann E, Novac N, Wels WS, Martoglio B, Hueber AO, Zörnig M
Cell Death Differ. 2007
PubMed ID: 17557115
Chemokine system and tissue infiltration in aggressive NK-cell leukemia.
Makishima H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F
Leuk Res. 2007
PubMed ID: 17123604
CTLs contain and use intracellular stores of FasL distinct from cytolytic granules.
He JS, Ostergaard HL
J Immunol. 2007
PubMed ID: 17675495
MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner.
Kim SH, Bianco NR, Shufesky WJ, Morelli AE, Robbins PD
J Immunol. 2007
PubMed ID: 17675484
[The expression of FasL and ICAM-1 on the HEVs in the hypertrophic tonsils].
Liu Y, Wang Z, Yu H, Wang F, Liu S, Cui Y
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007
PubMed ID: 17969524
Analysis of apoptotic markers Fas/FasL (CD95/CD95L) expression on the lymphocytes in patients with acute coronary syndrome.
Bossowska A, Bossowski A, Galar B
Kardiol Pol. 2007
PubMed ID: 17853317
The Fas/Fas-ligand pathway does not mediate the apoptosis in elastase-induced emphysema in mice.
Sawada M, Ohno Y, La BL, Funaguchi N, Asai T, Yuhgetsu H, Takemura G, Minatoguchi S, Fujiwara H, Fujiwara T
Exp Lung Res. 2007
PubMed ID: 17694438
IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease.
Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N, Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR
J Immunol. 2007
PubMed ID: 17641033
c-FLIP expression in colorectal carcinomas: association with Fas/FasL expression and prognostic implications.
Korkolopoulou P, Saetta AA, Levidou G, Gigelou F, Lazaris A, Thymara I, Scliri M, Bousboukea K, Michalopoulos NV, Apostolikas N, Konstantinidou A, Tzivras M, Patsouris E
Histopathology. 2007
PubMed ID: 17559541
Importance of FAS-1377, FAS-670, and FASL-844 polymorphisms in tumor onset, progression, and pigment phenotypes of Swedish patients with melanoma: a case-control analysis.
Zhang H, Sun XF, Synnerstad I, Rosdahl I
Cancer J. 2007
PubMed ID: 17762757
CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL.
Wesche-Soldato DE, Chung CS, Gregory SH, Salazar-Mather TP, Ayala CA, Ayala A
Am J Pathol. 2007
PubMed ID: 17591956
Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection.
de Oliveira GM, Diniz RL, Batista W, Batista MM, Bani Correa C, de Araújo-Jorge TC, Henriques-Pons A
Am J Pathol. 2007
PubMed ID: 17591955
Serum levels of sFas and sFasL during chemotherapy of lung cancer.
Naumnik W, Izycki T, Ossolinska M, Chyczewska E
Exp Oncol. 2007
PubMed ID: 17704746
A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas.
Villa-Morales M, Santos J, Pérez-Gómez E, Quintanilla M, Fernández-Piqueras J
Cancer Res. 2007
PubMed ID: 17545588
Fas ligand enhances hematopoietic cell engraftment through abrogation of alloimmune responses and nonimmunogenic interactions.
Pearl-Yafe M, Yolcu ES, Stein J, Kaplan O, Yaniv I, Shirwan H, Askenasy N
Stem Cells. 2007
PubMed ID: 17363551
Fetal growth restriction is associated with reduced FasL expression by decidual cells.
Eide IP, Isaksen CV, Salvesen KA, Langaas M, Günther CC, Iversen AC, Austgulen R
J Reprod Immunol. 2007
PubMed ID: 17196256
Loss of functional Fas ligand enhances intestinal tumorigenesis in the Min mouse model.
Fingleton B, Carter KJ, Matrisian LM
Cancer Res. 2007
PubMed ID: 17510409
Fas/Fas ligand gene polymorphism in patients with papillary thyroid cancer in the Turkish population.
Erdogan M, Karadeniz M, Berdeli A, Tamsel S, Ertan Y, Uluer H, Yilmaz C, Tuzun M, Kabalak T, Ozgen AG
J Endocrinol Invest. 2007
PubMed ID: 17598974
FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury.
Davis AR, Lotocki G, Marcillo AE, Dietrich WD, Keane RW
J Neurotrauma. 2007
PubMed ID: 17518537
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity.
Stranges PB, Watson J, Cooper CJ, Choisy-Rossi CM, Stonebraker AC, Beighton RA, Hartig H, Sundberg JP, Servick S, Kaufmann G, Fink PJ, Chervonsky AV
Immunity. 2007
PubMed ID: 17509906
Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production.
Matsumoto N, Imamura R, Suda T
FEBS J. 2007
PubMed ID: 17403042
ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.
Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P
Cell Death Differ. 2007
PubMed ID: 17290285
Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer.
Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, Shi Y, Tan W, Zhou Y, Zhao D, Zhang X, Guo Y, Lin D
Carcinogenesis. 2007
PubMed ID: 17183065
Fas ligand expression in TM4 Sertoli cells is enhanced by estradiol "in situ" production.
Catalano S, Rizza P, Gu G, Barone I, Giordano C, Marsico S, Casaburi I, Middea E, Lanzino M, Pellegrino M, Andò S
J Cell Physiol. 2007
PubMed ID: 17167783
[Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia]
Wang W, Lu NX, Xia YA, Wang XR, Zhang W, Song NH, Wei M, Su JT
Zhonghua Nan Ke Xue. 2007
PubMed ID: 17491259
Analysis of the -844C > T polymorphism in the promoter region of FASLgene in a cohort of Spanish HCV patients.
Ruiz-Ferrer M, Antiñolo G, Aguilar-Reina J
J Viral Hepat. 2007
PubMed ID: 17381722
The Fas death pathway controls coordinated expansions of type 1 CD8 and type 2 CD4 T cells in Trypanosoma cruzi infection.
Guillermo LV, Silva EM, Ribeiro-Gomes FL, De Meis J, Pereira WF, Yagita H, DosReis GA, Lopes MF
J Leukoc Biol. 2007
PubMed ID: 17261545
Anaplastic, plasmablastic, and plasmacytic plasmacytomas of mice: relationships to human plasma cell neoplasms and late-stage differentiation of normal B cells.
Qi CF, Zhou JX, Lee CH, Naghashfar Z, Xiang S, Kovalchuk AL, Fredrickson TN, Hartley JW, Roopenian DC, Davidson WF, Janz S, Morse HC
Cancer Res. 2007
PubMed ID: 17363561
The Fas/Fas ligand system inhibits differentiation of murine osteoblasts but has a limited role in osteoblast and osteoclast apoptosis.
Kovacić N, Lukić IK, Grcević D, Katavić V, Croucher P, Marusić A
J Immunol. 2007
PubMed ID: 17339432
Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer.
Gormus U, Ergen A, Yilmaz H, Dalan B, Berkman S, Isbir T
Anticancer Res. 2007
PubMed ID: 17465232
Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity.
Raghavendra PB, Sreenivasan Y, Manna SK
Mol Immunol. 2007
PubMed ID: 17173971
Involvement of the Fas-Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell-only syndrome.
Kim SK, Yoon YD, Park YS, Seo JT, Kim JH
Fertil Steril. 2007
PubMed ID: 17123522
Death receptor ligation triggers membrane scrambling between Golgi and mitochondria.
Ouasti S, Matarrese P, Paddon R, Khosravi-Far R, Sorice M, Tinari A, Malorni W, Degli Esposti M
Cell Death Differ. 2007
PubMed ID: 17008914
Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis.
Golan-Gerstl R, Wallach-Dayan SB, Amir G, Breuer R
Am J Respir Cell Mol Biol. 2007
PubMed ID: 16990614
Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Still's disease.
Chen DY, Lan JL, Lin FJ, Hsieh TY
Clin Rheumatol. 2007
PubMed ID: 16972019
Membrane-bound CD95 ligand expressed on human antigen-presenting cells prevents alloantigen-specific T cell response without impairment of viral and third-party T cell immunity.
Strauss G, Osen W, Knape I, Jacobsen EM, Müller SM, Debatin KM
Cell Death Differ. 2007
PubMed ID: 16902496
Transcriptional regulation of FasL expression and participation of sTNF-alpha in response to sertoli cell injury.
Yao PL, Lin YC, Sawhney P, Richburg JH
J Biol Chem. 2007
PubMed ID: 17192273
TNF-dependent overexpression of CCL21 is an underlying cause of progressive lymphoaccumulation in generalized lymphoproliferative disorder.
Wiede F, Vana K, Sedger LM, Lechner A, Körner H
Eur J Immunol. 2007
PubMed ID: 17236235
The human immunodeficiency virus type 1 tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism.
O'Hara SP, Small AJ, Nelson JB, Badley AD, Chen XM, Gores GJ, Larusso NF
Infect Immun. 2007
PubMed ID: 17118988
Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma.
Yamamoto T, Yokozeki H, Nishioka K
Arch Dermatol Res. 2007
PubMed ID: 17102953
Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells.
Yasuda T, Kuwabara T, Nakano H, Aritomi K, Onodera T, Lipp M, Takahama Y, Kakiuchi T
Blood. 2007
PubMed ID: 16973962
Concentrations of ssDNA in liver tissue and its correlation with sFas and sFasL in serum of patients infected with HBV, HCV, HCV and HIV.
Łapinski TW, Wiercińska-Drapało A, Panasiuk A, Kovalchuk O
Adv Med Sci. 2007
PubMed ID: 18217400
Myocardial Fas ligand expression increases susceptibility to AZT-induced cardiomyopathy.
Purevjav E, Nelson DP, Varela JJ, Jimenez S, Kearney DL, Sanchez XV, DeFreitas G, Carabello B, Taylor MD, Vatta M, Shearer WT, Towbin JA, Bowles NE
Cardiovasc Toxicol. 2007
PubMed ID: 17943461
Putative association of Fas and FasL gene polymorphisms with clinical outcomes of hepatitis B virus infection.
Jung YJ, Kim YJ, Kim LH, Lee SO, Park BL, Shin HD, Lee HS
Intervirology. 2007
PubMed ID: 17938571
Inhibition of apoptosis by expression of antiapoptotic proteins in recombinant human keratinocytes.
Choi CY, Reimers K, Allmeling C, Kall S, Choi YH, Vogt PM
Cell Transplant. 2007
PubMed ID: 17912957
Association analysis of chromosome 1 migraine candidate genes.
Fernandez F, Curtain RP, Colson NJ, Ovcaric M, MacMillan J, Griffiths LR
BMC Med Genet. 2007
PubMed ID: 17727731
Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib.
Bi LL, Pan G, Atkinson TP, Zheng L, Dale JK, Makris C, Reddy V, McDonald JM, Siegel RM, Puck JM, Lenardo MJ, Straus SE
BMC Med Genet. 2007
PubMed ID: 17605793
Fas/Fas-ligand expressions in primary breast cancer are significant predictors of its skeletal spread.
Bebenek M, Duś D, Koźlak J
Anticancer Res. 2007
PubMed ID: 17352235
The critical role of protein kinase C-theta in Fas/Fas ligand-mediated apoptosis.
Manicassamy S, Sun Z
J Immunol. 2007
PubMed ID: 17182568
Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.
Zuccato E, Blott EJ, Holt O, Sigismund S, Shaw M, Bossi G, Griffiths GM
J Cell Sci. 2007
PubMed ID: 17164290
Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death.
Nakano K, Saito K, Mine S, Matsushita S, Tanaka Y
Apoptosis. 2007
PubMed ID: 17136494
Apoptosis induced in HIV-1-exposed, resting CD4+ T cells subsequent to signaling through homing receptors is Fas/Fas ligand-mediated.
Ji J, Chen JJ, Braciale VL, Cloyd MW
J Leukoc Biol. 2007
PubMed ID: 17056762
Increased soluble Fas plasma levels in subjects at high cardiovascular risk: Atorvastatin on Inflammatory Markers (AIM) study, a substudy of ACTFAST.
Blanco-Colio LM, Martín-Ventura JL, de Teresa E, Farsang C, Gaw A, Gensini G, Leiter LA, Langer A, Martineau P, Hérnandez G, Egido J, ACTFAST investigators
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17053166
The suppression of delayed-type hypersensitivity by CD8+ regulatory T cells requires interferon-gamma.
Cone RE, Li X, Sharafieh R, O'Rourke J, Vella AT
Immunology. 2007
PubMed ID: 17052246
Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression.
Singh NP, Nagarkatti M, Nagarkatti PS
Mol Pharmacol. 2007
PubMed ID: 16940415
Disparate distribution of 16 candidate single nucleotide polymorphisms among racial and ethnic groups of pediatric heart transplant patients.
Girnita DM, Webber SA, Ferrell R, Burckart GJ, Brooks MM, McDade KK, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Girnita AL, Zeevi A
Transplantation. 2006
PubMed ID: 17198275
Loss of Fas ligand-function improves survival in G93A-transgenic ALS mice.
Petri S, Kiaei M, Wille E, Calingasan NY, Flint Beal M
J Neurol Sci. 2006
PubMed ID: 17049562
CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma.
Schmitz I, Meyer C, Schulze-Osthoff K
Oncogene. 2006
PubMed ID: 16767155
Hepatocellular apoptosis during Candida albicans colonization: involvement of TNF-alpha and infiltrating Fas-L positive lymphocytes.
Renna MS, Correa SG, Porporatto C, Figueredo CM, Aoki MP, Paraje MG, Sotomayor CE
Int Immunol. 2006
PubMed ID: 17053043
Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population.
Park SH, Choi JE, Kim EJ, Jang JS, Lee WK, Cha SI, Kim CH, Kam S, Kim DS, Park RW, Kim YC, Han SB, Jung TH, Park JY
Lung Cancer. 2006
PubMed ID: 17014925
Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress.
Wang X, Finegan KG, Robinson AC, Knowles L, Khosravi-Far R, Hinchliffe KA, Boot-Handford RP, Tournier C
Cell Death Differ. 2006
PubMed ID: 16710360
Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension.
Ju KR, Kim HS, Kim JH, Lee NY, Park CK
Brain Res. 2006
PubMed ID: 17045251
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death.
Fritzsching B, Oberle N, Pauly E, Geffers R, Buer J, Poschl J, Krammer P, Linderkamp O, Suri-Payer E
Blood. 2006
PubMed ID: 16868256
The effects of interleukin-10 on the expression of Fas and FasL in rat hepatic stellate cells.
Zhang L, Wang X, Zheng W, Shi M
Med Chem. 2006
PubMed ID: 17105443
Synergistic actions of pemphigus vulgaris IgG, Fas-ligand and tumor necrosis factor-alpha during induction of basal cell shrinkage and acantholysis.
Orlov MD, Chernyavsky AI, Arredondo J, Grando SA
Autoimmunity. 2006
PubMed ID: 17101499
Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism.
Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Aplin JD, Whitley GS
Am J Pathol. 2006
PubMed ID: 17071607
Fas ligand elicits a caspase-independent proinflammatory response in human keratinocytes: implications for dermatitis.
Farley SM, Dotson AD, Purdy DE, Sundholm AJ, Schneider P, Magun BE, Iordanov MS
J Invest Dermatol. 2006
PubMed ID: 16858424
Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene.
Wang CC, Zeng Q, Hwang LA, Guo K, Li J, Liew HC, Hong W
Biochem Biophys Res Commun. 2006
PubMed ID: 16935260
Exogenous expression of Fas-ligand or CrmA prolongs the survival in rat liver transplantation.
Adachi K, Fujino M, Kitazawa Y, Funeshima-Fuji N, Takahara S, Kimura H, Li XK
Transplant Proc. 2006
PubMed ID: 17098047
Fatal recall responses mediated by CD8 T cells during intracellular bacterial challenge infection.
Bitsaktsis C, Winslow G
J Immunol. 2006
PubMed ID: 16982903
Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.
Zhang Z, Wang LE, Sturgis EM, El-Naggar AK, Hong WK, Amos CI, Spitz MR, Wei Q
Clin Cancer Res. 2006
PubMed ID: 17000697
Irradiation-induced pneumonitis mediated by the CD95/CD95-ligand system.
Heinzelmann F, Jendrossek V, Lauber K, Nowak K, Eldh T, Boras R, Handrick R, Henkel M, Martin C, Uhlig S, Köhler D, Eltzschig HK, Wehrmann M, Budach W, Belka C
J Natl Cancer Inst. 2006
PubMed ID: 16954477
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
Marie JC, Liggitt D, Rudensky AY
Immunity. 2006
PubMed ID: 16973387
[Role of Fas-FasL and caspase-3 signal transduction pathway in promoting apoptosis of T lymphocyte subset in SLE patients]
Chen X, Wang LL, Cai B, Chen J, Feng WH
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006
PubMed ID: 16948902
CD4 T cell-dependent autoimmunity against a melanocyte neoantigen induces spontaneous vitiligo and depends upon Fas-Fas ligand interactions.
Lambe T, Leung JC, Bouriez-Jones T, Silver K, Makinen K, Crockford TL, Ferry H, Forrester JV, Cornall RJ
J Immunol. 2006
PubMed ID: 16920942
Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model.
Aprahamian T, Bonegio R, Rizzo J, Perlman H, Lefer DJ, Rifkin IR, Walsh K
J Immunol. 2006
PubMed ID: 16920939
A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.
Del-Rey M, Ruiz-Contreras J, Bosque A, Calleja S, Gomez-Rial J, Roldan E, Morales P, Serrano A, Anel A, Paz-Artal E, Allende LM
Blood. 2006
PubMed ID: 16627752
Macrophages inhibit neovascularization in a murine model of age-related macular degeneration.
Apte RS, Richter J, Herndon J, Ferguson TA
PLoS Med. 2006
PubMed ID: 16903779
The cytoplasmic domain of Fas ligand costimulates TCR signals.
Sun M, Ames KT, Suzuki I, Fink PJ
J Immunol. 2006
PubMed ID: 16849454
Overexpression of FasL in retinal pigment epithelial cells reduces choroidal neovascularization.
Semkova I, Fauser S, Lappas A, Smyth N, Kociok N, Kirchhof B, Paulsson M, Poulaki V, Joussen AM
FASEB J. 2006
PubMed ID: 16807368
Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells.
Mohamood AS, Trujillo CJ, Zheng D, Jie C, Murillo FM, Schneck JP, Hamad AR
Int Immunol. 2006
PubMed ID: 16769751
Fas-ligand is stored in secretory lysosomes of ocular barrier epithelia and released with microvesicles.
McKechnie NM, King BC, Fletcher E, Braun G
Exp Eye Res. 2006
PubMed ID: 16563377
Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL.
Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, Janssen O
Cell Signal. 2006
PubMed ID: 16318909
[Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat].
Wen T, Ren F, Liu Y, Wu ZM, Zhao JY
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006
PubMed ID: 16831245
Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development.
Zhang X, Cowan CM, Jiang X, Soo C, Miao S, Carpenter D, Wu B, Kuroda S, Ting K
Lab Invest. 2006
PubMed ID: 16652108
Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo.
Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M
Blood. 2006
PubMed ID: 16527892
Involvement of p38 mitogen-activated protein kinase and inducible nitric oxide synthase in apoptotic signaling of murine and human male germ cells after hormone deprivation.
Vera Y, Erkkilä K, Wang C, Nunez C, Kyttänen S, Lue Y, Dunkel L, Swerdloff RS, Sinha Hikim AP
Mol Endocrinol. 2006
PubMed ID: 16469770
Competition between glucocorticoid receptor and NFkappaB for control of the human FasL promoter.
Novac N, Baus D, Dostert A, Heinzel T
FASEB J. 2006
PubMed ID: 16770006
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis.
Yano T, Ito K, Fukamachi H, Chi XZ, Wee HJ, Inoue K, Ida H, Bouillet P, Strasser A, Bae SC, Ito Y
Mol Cell Biol. 2006
PubMed ID: 16738314
Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.
Ramirez-Montagut T, Chow A, Hirschhorn-Cymerman D, Terwey TH, Kochman AA, Lu S, Miles RC, Sakaguchi S, Houghton AN, van den Brink MR
J Immunol. 2006
PubMed ID: 16709800
Active transcription of the human FASL/CD95L/TNFSF6 promoter region in T lymphocytes involves chromatin remodeling: role of DNA methylation and protein acetylation suggest distinct mechanisms of transcriptional repression.
Castellano R, Vire B, Pion M, Quivy V, Olive D, Hirsch I, Van Lint C, Collette Y
J Biol Chem. 2006
PubMed ID: 16595663
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
Activated CD4+CD25+ T cells selectively kill B lymphocytes.
Zhao DM, Thornton AM, DiPaolo RJ, Shevach EM
Blood. 2006
PubMed ID: 16418326
[Effect of p, p'-DDE on DNA damage and expression of FasL gene of rat Sertoli cell in vitro]
Song Y, Yang KD
Wei Sheng Yan Jiu. 2006
PubMed ID: 16921742
Inhibition of Fas-mediated apoptosis through administration of soluble Fas receptor improves functional outcome and reduces posttraumatic axonal degeneration after acute spinal cord injury.
Ackery A, Robins S, Fehlings MG
J Neurotrauma. 2006
PubMed ID: 16689665
Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells.
Ivanov VN, Hei TK
Exp Cell Res. 2006
PubMed ID: 16487513
Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma.
Wang WS, Chen PM, Wang HS, Liang WY, Su Y
Carcinogenesis. 2006
PubMed ID: 16474169
Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively.
Hsiao HL, Wang WS, Chen PM, Su Y
Carcinogenesis. 2006
PubMed ID: 16364925
Role of endogenous Fas (CD95/Apo-1) ligand in balloon-induced apoptosis, inflammation, and neointima formation.
Matter CM, Chadjichristos CE, Meier P, von Lukowicz T, Lohmann C, Schuler PK, Zhang D, Odermatt B, Hofmann E, Brunner T, Kwak BR, Lüscher TF
Circulation. 2006
PubMed ID: 16606788
Stat1 deficiency in the host enhances interleukin-12-mediated tumor regression.
Torrero MN, Xia X, Henk W, Yu S, Li S
Cancer Res. 2006
PubMed ID: 16618773
Oral nickel tolerance: Fas ligand-expressing invariant NK T cells promote tolerance induction by eliciting apoptotic death of antigen-carrying, effete B cells.
Nowak M, Kopp F, Roelofs-Haarhuis K, Wu X, Gleichmann E
J Immunol. 2006
PubMed ID: 16585548
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse.
Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, Janssen O
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16595635
Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL.
Raoul C, Buhler E, Sadeghi C, Jacquier A, Aebischer P, Pettmann B, Henderson CE, Haase G
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16581901
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation.
Chen YH, Wu HL, Li C, Huang YH, Chiang CW, Wu MP, Wu LW
Thromb Haemost. 2006
PubMed ID: 16601838
NK cell-mediated immunopathology during an acute viral infection of the CNS.
Alsharifi M, Lobigs M, Simon MM, Kersten A, Müller K, Koskinen A, Lee E, Müllbacher A
Eur J Immunol. 2006
PubMed ID: 16541469
Differential roles of CD8+ and CD8- T lymphocytes in corneal allograft rejection in 'high-risk' hosts.
Niederkorn JY, Stevens C, Mellon J, Mayhew E
Am J Transplant. 2006
PubMed ID: 16539627
Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma.
Li C, Larson D, Zhang Z, Liu Z, Strom SS, Gershenwald JE, Prieto VG, Lee JE, Ross MI, Mansfield PF, Cormier JN, Duvic M, Grimm EA, Wei Q
Pharmacogenet Genomics. 2006
PubMed ID: 16538172
Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.
Li C, Wu W, Liu J, Qian L, Li A, Yang K, Wei Q, Zhou J, Zhang Z
Pharmacogenet Genomics. 2006
PubMed ID: 16538171
Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts.
Nachbur U, Kassahn D, Yousefi S, Legler DF, Brunner T
Blood. 2006
PubMed ID: 16332972
CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.
Bremer E, ten Cate B, Samplonius DF, de Leij LF, Helfrich W
Blood. 2006
PubMed ID: 16332967
Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice.
Hamano Y, Tsukamoto K, Abe M, Sun GD, Zhang D, Fujii H, Matsuoka S, Tanaka M, Ishida-Okawara A, Tachikawa H, Nishimura H, Tokunaka K, Hirose S, Suzuki K
J Immunol. 2006
PubMed ID: 16517735
Immunization with murine breast cancer cells treated with antisense oligodeoxynucleotides to type I insulin-like growth factor receptor induced an antitumoral effect mediated by a CD8+ response involving Fas/Fas ligand cytotoxic pathway.
Schillaci R, Salatino M, Cassataro J, Proietti CJ, Giambartolomei GH, Rivas MA, Carnevale RP, Charreau EH, Elizalde PV
J Immunol. 2006
PubMed ID: 16517711
Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity.
Cahuzac N, Baum W, Kirkin V, Conchonaud F, Wawrezinieck L, Marguet D, Janssen O, Zörnig M, Hueber AO
Blood. 2006
PubMed ID: 16282344
The role of receptor internalization in CD95 signaling.
Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, Peter ME, Chan AC
EMBO J. 2006
PubMed ID: 16498403
[The expression and role of Fas/FasL in infantile hemangioma]
Xing X, Ouyang TX, Yuan SM, Lu B, Ni CR, Yang ZY
Zhonghua Zheng Xing Wai Ke Za Zhi. 2006
PubMed ID: 16736614
Porphyromonas gingivalis enhances FasL expression via up-regulation of NFkappaB-mediated gene transcription and induces apoptotic cell death in human gingival epithelial cells.
Brozovic S, Sahoo R, Barve S, Shiba H, Uriarte S, Blumberg RS, Kinane DF
Microbiology. 2006
PubMed ID: 16514159
No association between selected candidate gene polymorphisms and severe chronic periodontitis.
Wohlfahrt JC, Wu T, Hodges JS, Hinrichs JE, Michalowicz BS
J Periodontol. 2006
PubMed ID: 16512757
Abnormal Fas/FasL and caspase-3-mediated apoptotic signaling pathways of T lymphocyte subset in patients with systemic lupus erythematosus.
Xue C, Lan-Lan W, Bei C, Jie C, Wei-Hua F
Cell Immunol. 2006
PubMed ID: 16808908
Study of Fas (CD95) and FasL (CD178) polymorphisms in liver transplant recipients.
Marín LA, Muro M, Moya-Quiles MR, Miras M, Minguela A, Bermejo J, Sanchez-Bueno F, Parrilla P, Alvarez-López MR
Tissue Antigens. 2006
PubMed ID: 16441482
Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi.
Shi C, Wolfe J, Russell JQ, Fortner K, Hardin N, Anguita J, Budd RC
Infect Immun. 2006
PubMed ID: 16428764
Involvement of Fas and FasL in Ectromelia virus-induced apoptosis in mouse brain.
Krzyzowska M, Cymerys J, Winnicka A, Niemiałtowski M
Virus Res. 2006
PubMed ID: 16169110
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
Lee CH, Melchers M, Wang H, Torrey TA, Slota R, Qi CF, Kim JY, Lugar P, Kong HJ, Farrington L, van der Zouwen B, Zhou JX, Lougaris V, Lipsky PE, Grammer AC, Morse HC
J Exp Med. 2006
PubMed ID: 16380510
Opposite roles of FAP-1 and dynamin in the regulation of Fas (CD95) translocation to the cell surface and susceptibility to Fas ligand-mediated apoptosis.
Ivanov VN, Ronai Z, Hei TK
J Biol Chem. 2006
PubMed ID: 16306044
Concentrations of soluble Fas and soluble Fas ligand as indicators of programmed cell death among patients coinfected with Human Immunodeficiency Virus and Hepatitis C Virus.
Lapinski TW, Jaroszewicz J, Wiercinska-Drapalo A
Viral Immunol. 2006
PubMed ID: 16987075
Oxidative stress increases Fas ligand expression in endothelial cells.
Suzuki M, Aoshiba K, Nagai A
J Inflamm (Lond). 2006
PubMed ID: 16854215
Sexual dimorphism in immune response genes as a function of puberty.
Lamason R, Zhao P, Rawat R, Davis A, Hall JC, Chae JJ, Agarwal R, Cohen P, Rosen A, Hoffman EP, Nagaraju K
BMC Immunol. 2006
PubMed ID: 16504066
Genetic deletion of fas receptors or Fas ligands does not reduce infarct size after acute global ischemia-reperfusion in isolated mouse heart.
Tekin D, Xi L, Kukreja RC
Cell Biochem Biophys. 2006
PubMed ID: 16456239
Atrophy of mesenteric lymph nodes in experimental Chagas' disease: differential role of Fas/Fas-L and TNFRI/TNF pathways.
de Meis J, Mendes-da-Cruz DA, Farias-de-Oliveira DA, Corrêa-de-Santana E, Pinto-Mariz F, Cotta-de-Almeida V, Bonomo A, Savino W
Microbes Infect. 2006
PubMed ID: 16239119
Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
Peng Y, Gallagher SF, Haines K, Baksh K, Murr MM
J Surg Res. 2006
PubMed ID: 16154149
Toll-like receptors 2 and 4 are differentially involved in Fas dependent apoptosis in Peyer's patch and the liver at an early stage after bile duct ligation in mice.
Ogawa A, Tagawa T, Nishimura H, Yajima T, Abe T, Arai T, Taniguchi M, Takeda K, Akira S, Nimura Y, Yoshikai Y
Gut. 2006
PubMed ID: 16118350
Control of neuronal branching by the death receptor CD95 (Fas/Apo-1).
Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A, del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba A
Cell Death Differ. 2006
PubMed ID: 16003386
Raf-1 sets the threshold of Fas sensitivity by modulating Rok-alpha signaling.
Piazzolla D, Meissl K, Kucerova L, Rubiolo C, Baccarini M
J Cell Biol. 2005
PubMed ID: 16365167
Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production.
Kidoya H, Umemura M, Kawabe T, Matsuzaki G, Yahagi A, Imamura R, Suda T
J Immunol. 2005
PubMed ID: 16339539
Binding of the intracellular Fas ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.
Baum W, Kirkin V, Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M
J Biol Chem. 2005
PubMed ID: 16204241
Lymph node dendritic cells control CD8+ T cell responses through regulated FasL expression.
Legge KL, Braciale TJ
Immunity. 2005
PubMed ID: 16356862
Interaction of Fas ligand and Fas expressed on osteoclast precursors increases osteoclastogenesis.
Park H, Jung YK, Park OJ, Lee YJ, Choi JY, Choi Y
J Immunol. 2005
PubMed ID: 16301623
Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia.
Nolsøe RL, Kelly JA, Pociot F, Moser KL, Kristiansen OP, Mandrup-Poulsen T, Harley JB
Genes Immun. 2005
PubMed ID: 16163374
Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia.
Peruzzi F, Bergonzini V, Aprea S, Reiss K, Sawaya BE, Rappaport J, Amini S, Khalili K
Brain Res Brain Res Rev. 2005
PubMed ID: 15936090
Expression of Fas and Fas-ligand and analysis of argyrophilic nucleolar organizer regions in squamous cell carcinoma: relationships with tumor stage and grade, and apoptosis.
Guler N, Uckan S, Celik I, Oznurlu Y, Uckan D
Int J Oral Maxillofac Surg. 2005
PubMed ID: 15907374
The C terminus of HIV-1 Tat modulates the extent of CD178-mediated apoptosis of T cells.
Campbell GR, Watkins JD, Esquieu D, Pasquier E, Loret EP, Spector SA
J Biol Chem. 2005
PubMed ID: 16155003
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A
J Exp Med. 2005
PubMed ID: 16260486
Pressure and endothelial coculture upregulate myocytic Fas-FasL pathway and induce apoptosis by way of direct and paracrine mechanisms.
Vouyouka AG, Lin L, Basson MD
Am J Surg. 2005
PubMed ID: 16226958
Mechanism of counterattack of colorectal cancer cell by Fas/Fas ligand system.
Zhu Q, Liu JY, Xu HW, Yang CM, Zhang AZ, Cui Y, Wang HB
World J Gastroenterol. 2005
PubMed ID: 16273638
FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer.
Sun T, Zhou Y, Li H, Han X, Shi Y, Wang L, Miao X, Tan W, Zhao D, Zhang X, Guo Y, Lin D
J Exp Med. 2005
PubMed ID: 16186185
The granule exocytosis and Fas/FasLigand pathways at the time of transplantation and during borderline and acute rejection of human renal allografts.
Carstens J, Markussen N, Madsen M
Transplant Proc. 2005
PubMed ID: 16298578
Polymorphisms in apoptosis genes predict response to infliximab therapy in luminal and fistulizing Crohn's disease.
Hlavaty T, Pierik M, Henckaerts L, Ferrante M, Joossens S, van Schuerbeek N, Noman M, Rutgeerts P, Vermeire S
Aliment Pharmacol Ther. 2005
PubMed ID: 16181301
Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients.
Nasi M, Pinti M, Bugarini R, Troiano L, Lugli E, Bellodi C, Mussini C, Borghi V, Trenti T, Balli F, Esposito R, Cossarizza A
Immunogenetics. 2005
PubMed ID: 16158329
The role of the tumor necrosis factor (TNF)--Fas L and HCV in the development of hepatocellular carcinoma.
Nada O, Abdel-Hamid M, Ismail A, El Shabrawy L, Sidhom KF, El Badawy NM, Ghazal FA, El Daly M, El Kafrawy S, Esmat G, Loffredo CA
J Clin Virol. 2005
PubMed ID: 16157266
Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum.
Allen HL, Deepe GS
J Clin Invest. 2005
PubMed ID: 16151533
Hyperoxia-induced apoptosis and Fas/FasL expression in lung epithelial cells.
De Paepe ME, Mao Q, Chao Y, Powell JL, Rubin LP, Sharma S
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 16148053
Genetic polymorphisms of FAS and FASL (CD95/CD95L) genes in cervical carcinogenesis: An analysis of haplotype and gene-gene interaction.
Lai HC, Lin WY, Lin YW, Chang CC, Yu MH, Chen CC, Chu TY
Gynecol Oncol. 2005
PubMed ID: 15996722
Presence of membrane and soluble forms of Fas ligand and of matrilysin (MMP-7) activity in normal and abnormal human semen.
Riccioli A, Dal Secco V, De Cesaris P, Starace D, Gandini L, Lenzi A, Dondero F, Padula F, Filippini A, Ziparo E
Hum Reprod. 2005
PubMed ID: 15979995
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation.
Muthumani K, Choo AY, Hwang DS, Premkumar A, Dayes NS, Harris C, Green DR, Wadsworth SA, Siekierka JJ, Weiner DB
Blood. 2005
PubMed ID: 15928037
Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease.
Landau AM, Luk KC, Jones ML, Siegrist-Johnstone R, Young YK, Kouassi E, Rymar VV, Dagher A, Sadikot AF, Desbarats J
J Exp Med. 2005
PubMed ID: 16129703
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Polymorphism of Fas and Fas ligand in preterm premature rupture of membranes in singleton pregnancies.
Fuks A, Parton LA, Polavarapu S, Netta D, Strassberg S, Godi I, Hsu CD
Am J Obstet Gynecol. 2005
PubMed ID: 16157125
The role of Fas ligand as an effector molecule in corneal graft rejection.
Stuart PM, Yin X, Plambeck S, Pan F, Ferguson TA
Eur J Immunol. 2005
PubMed ID: 16114107
Characterization of soluble FAS, FAS ligand and tumour necrosis factor-alpha in patients with chronic HCV infection.
Raghuraman S, Abraham P, Daniel HD, Ramakrishna BS, Sridharan G
J Clin Virol. 2005
PubMed ID: 16087126
Tumor exosomes expressing Fas ligand mediate CD8+ T-cell apoptosis.
Abusamra AJ, Zhong Z, Zheng X, Li M, Ichim TE, Chin JL, Min WP
Blood Cells Mol Dis. 2005
PubMed ID: 16081306
Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele.
Roesler J, Izquierdo JM, Ryser M, Rösen-Wolff A, Gahr M, Valcarcel J, Lenardo MJ, Zheng L
Blood. 2005
PubMed ID: 15870181
IL-21 enhances tumor rejection through a NKG2D-dependent mechanism.
Takaki R, Hayakawa Y, Nelson A, Sivakumar PV, Hughes S, Smyth MJ, Lanier LL
J Immunol. 2005
PubMed ID: 16081783
[Genetic polymorphisms of apoptosis-associated genes FAS and FASL and risk of colorectal cancer]
Yang S, Miao XP, Zhang XM, Sun T, Qu SN, Xiong P, Ye YJ, Guo YL, Tan W, Wang S, Lin DX
Zhonghua Yi Xue Za Zhi. 2005
PubMed ID: 16313826
Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes.
Alonso R, Rodríguez MC, Pindado J, Merino E, Mérida I, Izquierdo M
J Biol Chem. 2005
PubMed ID: 15870081
NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy.
Ross MJ, Martinka S, D'Agati VD, Bruggeman LA
J Am Soc Nephrol. 2005
PubMed ID: 15975999
FasL (CD95L/APO-1L) resistance of neurons mediated by phosphatidylinositol 3-kinase-Akt/protein kinase B-dependent expression of lifeguard/neuronal membrane protein 35.
Beier CP, Wischhusen J, Gleichmann M, Gerhardt E, Pekanovic A, Krueger A, Taylor V, Suter U, Krammer PH, Endres M, Weller M, Schulz JB
J Neurosci. 2005
PubMed ID: 16033886
Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction.
Litzinger MT, Su Y, Lei TC, Soukhareva N, Scott DW
J Immunol. 2005
PubMed ID: 16002674
Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium.
Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J, Kalyanaraman B
Biochem J. 2005
PubMed ID: 15799720
Role of cytokines in promoting immune escape of FasL-expressing human colon cancer cells.
Xu T, Sun BC, Li Q, Hao XS
World J Gastroenterol. 2005
PubMed ID: 15991293
Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.
Martin LJ, Chen K, Liu Z
J Neurosci. 2005
PubMed ID: 16000635
Mechanisms of apoptosis of T-cells in human tuberculosis.
Hirsch CS, Johnson JL, Okwera A, Kanost RA, Wu M, Peters P, Muhumuza M, Mayanja-Kizza H, Mugerwa RD, Mugyenyi P, Ellner JJ, Toossi Z
J Clin Immunol. 2005
PubMed ID: 16133992
FAS/FAS ligand ratio: a marker of oxaliplatin-based intrinsic and acquired resistance in advanced colorectal cancer.
Nadal C, Maurel J, Gallego R, Castells A, Longarón R, Marmol M, Sanz S, Molina R, Martin-Richard M, Gascón P
Clin Cancer Res. 2005
PubMed ID: 16000573
Fas ligand but not complement is critical for control of experimental Staphylococcus aureus Endophthalmitis.
Engelbert M, Gilmore MS
Invest Ophthalmol Vis Sci. 2005
PubMed ID: 15980239
Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.
Onoe T, Ohdan H, Tokita D, Shishida M, Tanaka Y, Hara H, Zhou W, Ishiyama K, Mitsuta H, Ide K, Asahara T
J Immunol. 2005
PubMed ID: 15972640
The influence of effector T cells and Fas ligand on lupus-associated B cells.
Fields ML, Nish SA, Hondowicz BD, Metzgar MH, Wharton GN, Caton AJ, Erikson J
J Immunol. 2005
PubMed ID: 15972636
Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells.
Camacho IA, Singh N, Hegde VL, Nagarkatti M, Nagarkatti PS
J Immunol. 2005
PubMed ID: 15972635
Mousepox conjunctivitis: the role of Fas/FasL-mediated apoptosis of epithelial cells in virus dissemination.
Krzyzowska M, Polanczyk M, Bas M, Cymerys J, Schollenberger A, Chiodi F, Niemialtowski M
J Gen Virol. 2005
PubMed ID: 15958680
Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus.
Price GE, Huang L, Ou R, Zhang M, Moskophidis D
J Virol. 2005
PubMed ID: 15956596
Action and mechanism of Fas and Fas ligand in immune escape of gallbladder carcinoma.
Xu LN, Zou SQ, Wang JM
World J Gastroenterol. 2005
PubMed ID: 15968727
Fas ligand expression in colon cancer: a possible mechanism of tumor immune privilege.
Zhang W, Ding EX, Wang Q, Zhu DQ, He J, Li YL, Wang YH
World J Gastroenterol. 2005
PubMed ID: 15962391
Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer.
Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y
J Exp Med. 2005
PubMed ID: 15967825
Peptide-specific CD8 T regulatory cells use IFN-gamma to elaborate TGF-beta-based suppression.
Myers L, Croft M, Kwon BS, Mittler RS, Vella AT
J Immunol. 2005
PubMed ID: 15944263
[The expression and significance of Fas/FasL in nasal polyps tissue].
Li Q, Ming W, Zhang H, Chen X, Jian J, Zhang D
Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005
PubMed ID: 16124644
Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer.
Zhang X, Miao X, Sun T, Tan W, Qu S, Xiong P, Zhou Y, Lin D
J Med Genet. 2005
PubMed ID: 15937082
Inflammatory arthritis requires Foxo3a to prevent Fas ligand-induced neutrophil apoptosis.
Jonsson H, Allen P, Peng SL
Nat Med. 2005
PubMed ID: 15895074
Hibiscus polyphenol-rich extract induces apoptosis in human gastric carcinoma cells via p53 phosphorylation and p38 MAPK/FasL cascade pathway.
Lin HH, Huang HP, Huang CC, Chen JH, Wang CJ
Mol Carcinog. 2005
PubMed ID: 15791651
Induction of stable mixed chimerism by embryonic stem cells requires functional Fas/FasL engagement.
Fabricius D, Bonde S, Zavazava N
Transplantation. 2005
PubMed ID: 15880040
Transfection of apoptosis related gene Fas ligand in human hepatocellular carcinoma cells and its significance in apoptosis.
Chen J, Su XS, Jiang YF, Gong GZ, Zheng YH, Li GY
World J Gastroenterol. 2005
PubMed ID: 15849828
[Expression of Fas antigen and ligand, placental growth factor in placenta of pregnant women with pre-eclampsia]
Yue XY, Zhang X, Cui SH, Wang XQ
Zhonghua Fu Chan Ke Za Zhi. 2005
PubMed ID: 15938782
The Nef-mediated AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with increased Fas/FasL expression on T cells and T-cell death but is not prevented in Fas-, FasL-, tumor necrosis factor receptor 1-, or interleukin-1be
Priceputu E, Rodrigue I, Chrobak P, Poudrier J, Mak TW, Hanna Z, Hu C, Kay DG, Jolicoeur P
J Virol. 2005
PubMed ID: 15858021
HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death.
Gülow K, Kaminski M, Darvas K, Süss D, Li-Weber M, Krammer PH
J Immunol. 2005
PubMed ID: 15843521
Polymorphisms in the promoter regions of FAS and FASL genes as candidate genetic factors conferring susceptibility to endometriosis.
Fernández RM, Noval JA, García-Lozano JC, Borrego S, Moliní JL, Antiñolo G
Int J Mol Med. 2005
PubMed ID: 15806311
Anti-CD3 induces bi-phasic apoptosis in murine intestinal epithelial cells: possible involvement of the Fas/Fas ligand system in different T cell compartments.
Miura N, Yamamoto M, Fukutake M, Ohtake N, Iizuka S, Ishige A, Sasaki H, Fukuda K, Yamamoto T, Hayakawa S
Int Immunol. 2005
PubMed ID: 15778290
Gamma delta T cells regulate the extent and duration of inflammation in the central nervous system by a Fas ligand-dependent mechanism.
Ponomarev ED, Dittel BN
J Immunol. 2005
PubMed ID: 15814692
Fetal expression of Fas ligand is necessary and sufficient for induction of CD8 T cell tolerance to the fetal antigen H-Y during pregnancy.
Vacchio MS, Hodes RJ
J Immunol. 2005
PubMed ID: 15814689
Fas ligand (CD178) cytoplasmic tail is a positive regulator of Fas ligand-mediated cytotoxicity.
Jodo S, Pidiyar VJ, Xiao S, Furusaki A, Sharma R, Koike T, Ju ST
J Immunol. 2005
PubMed ID: 15814666
Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells.
Dicker F, Kater AP, Fukuda T, Kipps TJ
Blood. 2005
PubMed ID: 15339846
Resistance to activation-induced cell death and bystander cytotoxicity via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas.
Ni X, Zhang C, Talpur R, Duvic M
J Invest Dermatol. 2005
PubMed ID: 15816832
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility.
Wang X, Ria M, Kelmenson PM, Eriksson P, Higgins DC, Samnegård A, Petros C, Rollins J, Bennet AM, Wiman B, de Faire U, Wennberg C, Olsson PG, Ishii N, Sugamura K, Hamsten A, Forsman-Semb K, Lagercrantz J, Paigen B
Nat Genet. 2005
PubMed ID: 15750594
p21 (Waf1/Cip1) and FasL gene activation via Sp1 and NFkappaB is required for leukemia cell survival but not for cell death induced by diverse stimuli.
Savickiene J, Treigyte G, Magnusson KE, Navakauskiene R
Int J Biochem Cell Biol. 2005
PubMed ID: 15694838
Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression.
Bosque A, Pardo J, Martínez-Lorenzo MJ, Iturralde M, Marzo I, Piñeiro A, Alava MA, Naval J, Anel A
J Leukoc Biol. 2005
PubMed ID: 15653751
The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability.
Henkler F, Behrle E, Dennehy KM, Wicovsky A, Peters N, Warnke C, Pfizenmaier K, Wajant H
J Cell Biol. 2005
PubMed ID: 15795317
Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy.
Gajate C, Mollinedo F
J Biol Chem. 2005
PubMed ID: 15659383
Association of NKT cells and granulocytes with liver injury after reperfusion of the portal vein.
Shimamura K, Kawamura H, Nagura T, Kato T, Naito T, Kameyama H, Hatakeyama K, Abo T
Cell Immunol. 2005
PubMed ID: 15963482
Relationship of acute lung inflammatory injury to Fas/FasL system.
Neff TA, Guo RF, Neff SB, Sarma JV, Speyer CL, Gao H, Bernacki KD, Huber-Lang M, McGuire S, Hoesel LM, Riedemann NC, Beck-Schimmer B, Zetoune FS, Ward PA
Am J Pathol. 2005
PubMed ID: 15743781
The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE.
Chen JY, Wang CM, Ma CC, Chow YH, Luo SF
Genes Immun. 2005
PubMed ID: 15674374
The aryl hydrocarbon receptor predisposes hepatocytes to Fas-mediated apoptosis.
Park KT, Mitchell KA, Huang G, Elferink CJ
Mol Pharmacol. 2005
PubMed ID: 15550680
Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host disease.
Maeda Y, Levy RB, Reddy P, Liu C, Clouthier SG, Teshima T, Ferrara JL
Blood. 2005
PubMed ID: 15466930
Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1.
Hsu LJ, Schultz L, Mattison J, Lin YS, Chang NS
Biochem Biophys Res Commun. 2005
PubMed ID: 15629131
Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance.
Cosson E, Bringuier AF, Paries J, Guillot R, Vaysse J, Attali JR, Feldmann G, Valensi P
Diabetes Metab. 2005
PubMed ID: 15803113
Cross-Talk between Fas/Fas ligand system and nitric oxide in the pathway subserving granulosa cell apoptosis: a possible regulatory mechanism for ovarian follicle atresia.
Chen Q, Yano T, Matsumi H, Osuga Y, Yano N, Xu J, Wada O, Koga K, Fujiwara T, Kugu K, Taketani Y
Endocrinology. 2005
PubMed ID: 15528299
Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis.
Jayanthi S, Deng X, Ladenheim B, McCoy MT, Cluster A, Cai NS, Cadet JL
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15644446
Potential genetic modifiers of the cystic fibrosis intestinal inflammatory phenotype on mouse chromosomes 1, 9, and 10.
Norkina O, De Lisle RC
BMC Genet. 2005
PubMed ID: 15921521
Altered expression of membrane-bound and soluble CD95/Fas contributes to the resistance of fibrotic lung fibroblasts to FasL induced apoptosis.
Bühling F, Wille A, Röcken C, Wiesner O, Baier A, Meinecke I, Welte T, Pap T
Respir Res. 2005
PubMed ID: 15833141
Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level.
Frängsmyr L, Baranov V, Nagaeva O, Stendahl U, Kjellberg L, Mincheva-Nilsson L
Mol Hum Reprod. 2005
PubMed ID: 15579659
CD95L mediates tumor counterattack in vitro but induces neutrophil-independent tumor rejection in vivo.
Igney FH, Behrens CK, Krammer PH
Int J Cancer. 2005
PubMed ID: 15386427
Independent roles of perforin, granzymes, and Fas in the control of Friend retrovirus infection.
Zelinskyy G, Balkow S, Schimmer S, Schepers K, Simon MM, Dittmer U
Virology. 2004
PubMed ID: 15567431
Fas ligand is required for resolution of granulomatous experimental autoimmune thyroiditis.
Wei Y, Chen K, Sharp GC, Braley-Mullen H
J Immunol. 2004
PubMed ID: 15585889
Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.
Zhang JQ, Okumura C, McCarty T, Shin MS, Mukhopadhyay P, Hori M, Torrey TA, Naghashfar Z, Zhou JX, Lee CH, Roopenian DC, Morse HC, Davidson WF
J Exp Med. 2004
PubMed ID: 15583018
Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIP.
de Groot-Kruseman HA, Baan CC, Zondervan PE, de Weger RA, Niesters HG, Balk AH, Weimar W
Transplant Proc. 2004
PubMed ID: 15686714
Acute pancreatitis induces FasL gene expression and apoptosis in the liver.
Gallagher SF, Yang J, Baksh K, Haines K, Carpenter H, Epling-Burnette PK, Peng Y, Norman J, Murr MM
J Surg Res. 2004
PubMed ID: 15555619
Sustained activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase pathways by hepatitis B virus X protein mediates apoptosis via induction of Fas/FasL and tumor necrosis factor (TNF) receptor 1/TNF-alpha expression.
Wang WH, Grégori G, Hullinger RL, Andrisani OM
Mol Cell Biol. 2004
PubMed ID: 15542843
Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.
Imamura R, Konaka K, Matsumoto N, Hasegawa M, Fukui M, Mukaida N, Kinoshita T, Suda T
J Biol Chem. 2004
PubMed ID: 15337758
Induction of apoptosis and activation of NF-kappaB by CD95 require different signalling thresholds.
Legembre P, Barnhart BC, Zheng L, Vijayan S, Straus SE, Puck J, Dale JK, Lenardo M, Peter ME
EMBO Rep. 2004
PubMed ID: 15514680
Fas-ligand expression on nucleus pulposus begins in developing embryo.
Inui Y, Nishida K, Doita M, Takada T, Miyamoto H, Yoshiya S, Kurosaka M
Spine. 2004
PubMed ID: 15507796
Impaired apoptosis of lymphocytes derived from patient with decreased expression of caspase-8 results in Alps-like phenotype.
Grzela T, Krauze A, Grzela K, Lazarczyk M, Niderla J, Brawura-Biskupski-Samaha R, Dziunycz P, Milewski L, Korczak-Kowalska G, Kulus M
Int J Mol Med. 2004
PubMed ID: 15492869
Role of soluble Fas ligand in autoimmune diseases.
Li NL, Nie H, Yu QW, Zhang JY, Ma AL, Shen BH, Wang L, Bai J, Chen XH, Zhou T, Zhang DQ
World J Gastroenterol. 2004
PubMed ID: 15457562
Novel negative regulator of expression in Fas ligand (CD178) cytoplasmic tail: evidence for translational regulation and against Fas ligand retention in secretory lysosomes.
Xiao S, Deshmukh US, Jodo S, Koike T, Sharma R, Furusaki A, Sung SS, Ju ST
J Immunol. 2004
PubMed ID: 15470053
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Ontogenesis and cell specific localization of Fas ligand expression in the rat testis.
D'Abrizio P, Baldini E, Russo PF, Biordi L, Graziano FM, Rucci N, Properzi G, Francavilla S, Ulisse S
Int J Androl. 2004
PubMed ID: 15379972
Fas ligand expression in human pancreatic cancer.
Ohta T, Elnemr A, Kitagawa H, Kayahara M, Takamura H, Fujimura T, Nishimura G, Shimizu K, Yi SQ, Miwa K
Oncol Rep. 2004
PubMed ID: 15375495
Fas/FasL-mediated apoptosis in perinatal murine lungs.
De Paepe ME, Mao Q, Embree-Ku M, Rubin LP, Luks FI
Am J Physiol Lung Cell Mol Physiol. 2004
PubMed ID: 15355863
The critical role of Fas-Fas ligand interaction in donor-specific transfusion-induced tolerance to H-Y antigen.
Minagawa R, Okano S, Tomita Y, Kishihara K, Yamada H, Nomoto K, Shimada M, Maehara Y, Sugimachi K, Yoshikai Y, Nomoto K
Transplantation. 2004
PubMed ID: 15385797
Murine male germ cell apoptosis induced by busulfan treatment correlates with loss of c-kit-expression in a Fas/FasL- and p53-independent manner.
Choi YJ, Ok DW, Kwon DN, Chung JI, Kim HC, Yeo SM, Kim T, Seo HG, Kim JH
FEBS Lett. 2004
PubMed ID: 15388331
The Tlx gene regulates the timing of neurogenesis in the cortex.
Roy K, Kuznicki K, Wu Q, Sun Z, Bock D, Schutz G, Vranich N, Monaghan AP
J Neurosci. 2004
PubMed ID: 15385616
Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure.
Li Y, Takemura G, Kosai K, Takahashi T, Okada H, Miyata S, Yuge K, Nagano S, Esaki M, Khai NC, Goto K, Mikami A, Maruyama R, Minatoguchi S, Fujiwara T, Fujiwara H
Circ Res. 2004
PubMed ID: 15297380
Fas-Fas ligand interactions are essential for the binding to and killing of activated macrophages by gamma delta T cells.
Dalton JE, Howell G, Pearson J, Scott P, Carding SR
J Immunol. 2004
PubMed ID: 15356111
Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro.
Wang XZ, Zhang SJ, Chen YX, Chen ZX, Huang YH, Zhang LJ
World J Gastroenterol. 2004
PubMed ID: 15309723
Synergistic induction of the Fas (CD95) ligand promoter by Max and NFkappaB in human non-small lung cancer cells.
Wiener Z, Ontsouka EC, Jakob S, Torgler R, Falus A, Mueller C, Brunner T
Exp Cell Res. 2004
PubMed ID: 15302589
TRANCE counteracts FasL-mediated apoptosis of murine bone marrow-derived dendritic cells.
Chen A, Xu H, Choi Y, Wang B, Zheng G
Cell Immunol. 2004
PubMed ID: 15919368
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells.
Tsukinoki T, Sugiyama H, Sunami R, Kobayashi M, Onoda T, Maeshima Y, Yamasaki Y, Makino H
Clin Exp Nephrol. 2004
PubMed ID: 15480896
Prolonged production of TNF-alpha exacerbates illness during respiratory syncytial virus infection.
Rutigliano JA, Graham BS
J Immunol. 2004
PubMed ID: 15322205
Vulnerability of mouse cortical neurons to doxorubicin-induced apoptosis is strain-dependent and is correlated with mRNAs encoding Fas, Fas-Ligand, and metalloproteinases.
Wetzel M, Tibbitts J, Rosenberg GA, Cunningham LA
Apoptosis. 2004
PubMed ID: 15314293
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
Steinbach JP, Eisenmann C, Klumpp A, Weller M
Biochem Biophys Res Commun. 2004
PubMed ID: 15358139
Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.
Yoo YG, Lee MO
J Biol Chem. 2004
PubMed ID: 15173177
CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells.
Barnhart BC, Legembre P, Pietras E, Bubici C, Franzoso G, Peter ME
EMBO J. 2004
PubMed ID: 15272306
Serum levels of soluble molecules associated with evasion of immune surveillance: a study in biliary disease.
Enjoji M, Yamaguchi K, Nakashima M, Ohta S, Kotoh K, Fukushima M, Kuniyoshi M, Tanaka M, Nakamuta M, Watanabe T, Nawata H
Liver Int. 2004
PubMed ID: 15287856
Ongoing myocardial damage in chronic heart failure is related to activated tumor necrosis factor and Fas/Fas ligand system.
Setsuta K, Seino Y, Ogawa T, Ohtsuka T, Seimiya K, Takano T
Circ J. 2004
PubMed ID: 15277733
The rate of the CD8-dependent initial reduction in tumor volume is not limited by contact-dependent perforin, Fas ligand, or TNF-mediated cytolysis.
Hollenbaugh JA, Reome J, Dobrzanski M, Dutton RW
J Immunol. 2004
PubMed ID: 15265903
Termination of antigen-specific immunity by CD95 ligand (Fas ligand) and IL-10.
Barreiro R, Luker G, Herndon J, Ferguson TA
J Immunol. 2004
PubMed ID: 15265879
Involvement of IL-17 in Fas ligand-induced inflammation.
Umemura M, Kawabe T, Shudo K, Kidoya H, Fukui M, Asano M, Iwakura Y, Matsuzaki G, Imamura R, Suda T
Int Immunol. 2004
PubMed ID: 15237105
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice.
Yang J, Sato K, Aprahamian T, Brown NJ, Hutcheson J, Bialik A, Perlman H, Walsh K
Arterioscler Thromb Vasc Biol. 2004
PubMed ID: 15178561
Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma.
Sun T, Miao X, Zhang X, Tan W, Xiong P, Lin D
J Natl Cancer Inst. 2004
PubMed ID: 15240787
Fas ligand is enriched in the caveolae membrane domains of thymic epithelial cells.
Lalor D, Liu P, Hayashi J
Cell Immunol. 2004
PubMed ID: 15541714
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.
Jin H, Carrio R, Yu A, Malek TR
J Immunol. 2004
PubMed ID: 15210829
A potent modifier of liver cancer risk on distal mouse chromosome 1: linkage analysis and characterization of congenic lines.
Bilger A, Bennett LM, Carabeo RA, Chiaverotti TA, Dvorak C, Liss KM, Schadewald SA, Pitot HC, Drinkwater NR
Genetics. 2004
PubMed ID: 15238534
c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations.
Korkolopoulou P, Goudopoulou A, Voutsinas G, Thomas-Tsagli E, Kapralos P, Patsouris E, Saetta AA
Urology. 2004
PubMed ID: 15183989
Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma.
Murakami M, Sasaki T, Miyata H, Yamasaki S, Kuwahara K, Chayama K
Oncol Rep. 2004
PubMed ID: 15138553
Regulation of Fas ligand expression by vascular endothelial growth factor in endometrial stromal cells in vitro.
Berkkanoglu M, Guzeloglu-Kayisli O, Kayisli UA, Selam BF, Arici A
Mol Hum Reprod. 2004
PubMed ID: 15073283
T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis.
Hao Z, Hampel B, Yagita H, Rajewsky K
J Exp Med. 2004
PubMed ID: 15148335
Regulation of interleukin-2 induced soluble Fas ligand release from human peripheral blood mononuclear cells.
Mauz-Körholz C, Banning U, Körholz D
Immunol Invest. 2004
PubMed ID: 15195700
Pro-Th1 cytokines promote Fas-dependent apoptosis of immature peripheral basophils.
Schneider E, Tonanny MB, Lisbonne M, Leite-de-Moraes M, Dy M
J Immunol. 2004
PubMed ID: 15100264
Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand.
Kosiewicz MM, Alard P, Liang S, Clark SL
Int Immunol. 2004
PubMed ID: 15096489
Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells.
Xiao S, Zhang X, Mann KK, Jodo S, Li L, Jarjour WN, Marshak-Rothstein A, Sherr DH, Ju ST
Int Immunol. 2004
PubMed ID: 15096479
The human melanoma cell line MelJuSo secretes bioactive FasL and APO2L/TRAIL on the surface of microvesicles. Possible contribution to tumor counterattack.
Martínez-Lorenzo MJ, Anel A, Alava MA, Piñeiro A, Naval J, Lasierra P, Larrad L
Exp Cell Res. 2004
PubMed ID: 15093732
Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease.
Aprahamian T, Rifkin I, Bonegio R, Hugel B, Freyssinet JM, Sato K, Castellot JJ, Walsh K
J Exp Med. 2004
PubMed ID: 15096538
Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia.
Li W, Fu J, Wang F, Yu G, Wang Y, Zhang X
Cell Mol Immunol. 2004
PubMed ID: 16212902
HIV/SIV escape from immune surveillance: focus on Nef.
Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M
Curr HIV Res. 2004
PubMed ID: 15078178
Spatiotemporal analysis of programmed cell death during mouse cardiac septation.
Sharma PR, Anderson RH, Copp AJ, Henderson DJ
Anat Rec A Discov Mol Cell Evol Biol. 2004
PubMed ID: 15052663
Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta.
Alard P, Clark SL, Kosiewicz MM
Eur J Immunol. 2004
PubMed ID: 15048712
Genomic analysis of Fas and FasL genes and absence of correlation with disease progression in AIDS.
Vasilescu A, Heath SC, Diop G, Do H, Hirtzig T, Hendel H, Bertin-Maghit S, Rappaport J, Therwath A, Lathrop GM, Matsuda F, Zagury JF
Immunogenetics. 2004
PubMed ID: 15042330
Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells.
Hiatt K, Ingram DA, Huddleston H, Spandau DF, Kapur R, Clapp DW
Am J Pathol. 2004
PubMed ID: 15039234
Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression.
Takemura Y, Fukuo K, Yasuda O, Inoue T, Inomata N, Yokoi T, Kawamoto H, Suhara T, Ogihara T
Hypertension. 2004
PubMed ID: 14967838
CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes.
Reinehr R, Görg B, Höngen A, Häussinger D
J Biol Chem. 2004
PubMed ID: 14679192
Expression of FasL and perforin/granzyme B mRNA in chronic hepatitis B virus infection.
Lee JY, Chae DW, Kim SM, Nam ES, Jang MK, Lee JH, Kim HY, Yoo JY
J Viral Hepat. 2004
PubMed ID: 14996347
Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome.
Strand S, Strand D, Seufert R, Mann A, Lotz J, Blessing M, Lahn M, Wunsch A, Broering DC, Hahn U, Grischke EM, Rogiers X, Otto G, Gores GJ, Galle PR
Gastroenterology. 2004
PubMed ID: 14988839
Expression of FasL by tumor cells does not abrogate anti-tumor CTL function.
Lee SH, Bar-Haim E, Goldberger O, Reich-Zeliger S, Vadai E, Tzehoval E, Eisenbach L
Immunol Lett. 2004
PubMed ID: 15019279
Altered expression of FAS system is related to adverse clinical outcome in stage I-II breast cancer patients treated with adjuvant anthracycline-based chemotherapy.
Botti C, Buglioni S, Benevolo M, Giannarelli D, Papaldo P, Cognetti F, Vici P, Di Filippo F, Del Nonno F, Venanzi FM, Natali PG, Mottolese M
Clin Cancer Res. 2004
PubMed ID: 14977837
CD4+ T cells regulate CD8+ T cell-mediated cutaneous immune responses by restricting effector T cell development through a Fas ligand-dependent mechanism.
Gorbachev AV, Fairchild RL
J Immunol. 2004
PubMed ID: 14764697
Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.
Karray S, Kress C, Cuvellier S, Hue-Beauvais C, Damotte D, Babinet C, Lévi-Strauss M
J Immunol. 2004
PubMed ID: 14764677
Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt.
Remy I, Michnick SW
Mol Cell Biol. 2004
PubMed ID: 14749367
NF-kappaB activation and Fas ligand overexpression in blood and plaques of patients with carotid atherosclerosis: potential implication in plaque instability.
Martín-Ventura JL, Blanco-Colio LM, Muñoz-García B, Gómez-Hernández A, Arribas A, Ortega L, Tuñón J, Egido J
Stroke. 2004
PubMed ID: 14739407
IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells.
Roth E, Pircher H
J Immunol. 2004
PubMed ID: 14734739
Soluble Fas and soluble FasL in multiple organ dysfunction syndrome complicating diffuse peritonitis.
Kitamura M, Endo S, Sato N, Yaegashi Y, Suxzuki Y, Kojika N, Wakabayashi G
Res Commun Mol Pathol Pharmacol. 2004
PubMed ID: 17564320
Role of the receptor-mediated apoptosis in Helicobacter pylori in gastric epithelial cells.
Ledig S, Wagner S, Manns MP, Beil W, Athmann C
Digestion. 2004
PubMed ID: 15557763
Essential role for hematopoietic Fas ligand (FasL) in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice.
Hall CL, Yao M, Hill LL, Owen-Schaub LB
Clin Exp Metastasis. 2004
PubMed ID: 15387375
A study of promoter and intronic markers of ApoI/Fas gene and the interaction with Fas ligand in relapsing multiple sclerosis.
Lucas M, Zayas MD, De Costa AF, Solano F, Chadli A, Dinca L, Izquierdo G
Eur Neurol. 2004
PubMed ID: 15218339
Human Fas-ligand expression on porcine endothelial cells does not protect against xenogeneic natural killer cytotoxicity.
Matter-Reissmann UB, Sonntag KC, Gilli UO, Leguern C, Schneider MK, Seebach JD
Xenotransplantation. 2004
PubMed ID: 14962292
The Fas promoter polymorphism at position -670 is not associated with late-onset sporadic Alzheimer's disease.
Rosenmann H, Meiner Z, Kahana E, Aladjem Z, Friedman G, Ben-Yehuda A, Grenader T, Wertman E, Abramsky O
Dement Geriatr Cogn Disord. 2004
PubMed ID: 14739535
Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses.
Choi C, Benveniste EN
Brain Res Brain Res Rev. 2004
PubMed ID: 14739003
CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS.
Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, de Andrade M, McMurray CT, Weinshenker BG
J Neuroimmunol. 2004
PubMed ID: 14698859
NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy.
Hayakawa Y, Screpanti V, Yagita H, Grandien A, Ljunggren HG, Smyth MJ, Chambers BJ
J Immunol. 2004
PubMed ID: 14688317
Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death.
Xiao S, Sung SS, Fu SM, Ju ST
J Biol Chem. 2003
PubMed ID: 14525977
CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants.
Eberle J, Fecker LF, Hossini AM, Wieder T, Daniel PT, Orfanos CE, Geilen CC
Oncogene. 2003
PubMed ID: 14668794
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells.
Tone M, Tone Y, Adams E, Yates SF, Frewin MR, Cobbold SP, Waldmann H
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14608036
Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM): expression of Fas ligand/Fas-mediated apoptosis signaling molecules in luteal cells.
Kiso M, Manabe N, Komatsu K, Shimabe M, Miyamoto H
J Reprod Dev. 2003
PubMed ID: 14967896
Expression of Fas and Fas ligand protein and mRNA in mouse oocytes and embryos.
Kelkar RL, Dharma SJ, Nandedkar TD
Reproduction. 2003
PubMed ID: 14748698
Overexpression of HBxAg in hepatocellular carcinoma and its relationship with Fas/FasL system.
Wang XZ, Chen XC, Chen YX, Zhang LJ, Li D, Chen FL, Chen ZX, Chen HY, Tao QM
World J Gastroenterol. 2003
PubMed ID: 14669310
Protection against murine leukemia virus-induced spongiform myeloencephalopathy in mice overexpressing Bcl-2 but not in mice deficient for interleukin-6, inducible nitric oxide synthetase, ICE, Fas, Fas ligand, or TNF-R1 genes.
Jolicoeur P, Hu C, Mak TW, Martinou JC, Kay DG
J Virol. 2003
PubMed ID: 14645573
Mechanisms of caspase activation.
Boatright KM, Salvesen GS
Curr Opin Cell Biol. 2003
PubMed ID: 14644197
Fibronectin-associated Fas ligand rapidly induces opposing and time-dependent effects on the activation and apoptosis of T cells.
Zanin-Zhorov A, Hershkoviz R, Hecht I, Cahalon L, Lider O
J Immunol. 2003
PubMed ID: 14634098
Regulation of Fas (APO-1, CD95) and Fas ligand expression in leukocytes during systemic inflammation in humans.
Marsik C, Halama T, Cardona F, Wlassits W, Mayr F, Pleiner J, Jilma B
Shock. 2003
PubMed ID: 14625471
Non-functional Fas ligand increases the formation of cartilage early in the endochondral bone induction by rhBMP-2.
Katavić V, Grcević D, Lukić IK, Vucenik V, Kovacić N, Kalajzić I, Marusić A
Life Sci. 2003
PubMed ID: 14575809
Induction of FAS ligand expression in a human hepatoblastoma cell line by HCV core protein.
Ruggieri A, Murdolo M, Rapicetta M
Virus Res. 2003
PubMed ID: 14602201
Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression.
Canbay A, Feldstein AE, Higuchi H, Werneburg N, Grambihler A, Bronk SF, Gores GJ
Hepatology. 2003
PubMed ID: 14578857
Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses.
Droin NM, Pinkoski MJ, Dejardin E, Green DR
Mol Cell Biol. 2003
PubMed ID: 14560009
Soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase 3 in the cerebrospinal fluid of infants with posthemorrhagic and nonhemorrhagic hydrocephalus.
Felderhoff-Mueser U, Buhrer C, Groneck P, Obladen M, Bartmann P, Heep A
Pediatr Res. 2003
PubMed ID: 12867600
Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells.
Ciechomska I, Pyrzynska B, Kazmierczak P, Kaminska B
Oncogene. 2003
PubMed ID: 14576824
Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL.
Syed V, Ho SM
Oncogene. 2003
PubMed ID: 14534535
The tolerogenic molecule CD95-L is expressed on the plasma membrane of human activated, but not resting, Langerhans' cells.
De Panfilis G, Venturini M, Lavazza A, Mommaas MA, Semenza D, Torresani C, Pasolini G
Exp Dermatol. 2003
PubMed ID: 14705811
Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina.
Péquignot MO, Provost AC, Sallé S, Taupin P, Sainton KM, Marchant D, Martinou JC, Ameisen JC, Jais JP, Abitbol M
Dev Dyn. 2003
PubMed ID: 14517994
Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis.
Dan N, Kanai T, Totsuka T, Iiyama R, Yamazaki M, Sawada T, Miyata T, Yagita H, Okumura K, Watanabe M
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12969829
The role of TNF-TNFR2 interactions in generation of CTL responses and clearance of hepatic adenovirus infection.
Kafrouni MI, Brown GR, Thiele DL
J Leukoc Biol. 2003
PubMed ID: 12960267
Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element.
Crist SA, Griffith TS, Ratliff TL
J Biol Chem. 2003
PubMed ID: 12855690
NK T cells stimulated with a ligand for TLR2 at least partly contribute to liver injury caused by Escherichia coli infection in mice.
Hiromatsu T, Matsuguchi T, Shimizu H, Yajima T, Nishimura H, Arai T, Nimura Y, Yoshikai Y
Eur J Immunol. 2003
PubMed ID: 12938227
Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal.
Chakour R, Guler R, Bugnon M, Allenbach C, Garcia I, Mauël J, Louis J, Tacchini-Cottier F
Infect Immun. 2003
PubMed ID: 12933876
Fas ligand is not constitutively expressed in low-grade B-cell lymphoma and B-lymphoblastoid cells.
Grüllich C, Richter M, Exner S, Finke J
Eur J Haematol. 2003
PubMed ID: 12930319
The Fas/Fas ligand pathway is important for optimal tumor regression in a mouse model of CTL adoptive immunotherapy of experimental CMS4 lung metastases.
Caldwell SA, Ryan MH, McDuffie E, Abrams SI
J Immunol. 2003
PubMed ID: 12928387
Two distinct mechanisms for induction of dendritic cell apoptosis in response to intact Streptococcus pneumoniae.
Colino J, Snapper CM
J Immunol. 2003
PubMed ID: 12928382
Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system.
Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A
J Immunol. 2003
PubMed ID: 12928375
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation.
Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS
Nat Med. 2003
PubMed ID: 12925844
Fas ligand expression in the organ of Corti.
Bodmer D, Brors D, Bodmer M, Pak K, Ryan AF
Audiol Neurootol. 2003
PubMed ID: 12904679
Stimulation of Kv1.3 potassium channels by death receptors during apoptosis in Jurkat T lymphocytes.
Storey NM, Gómez-Angelats M, Bortner CD, Armstrong DL, Cidlowski JA
J Biol Chem. 2003
PubMed ID: 12807917
Expression of Fas antigen and Fas ligand in bronchoalveolar lavage from silicosis patients.
Hamzaoui A, Ammar J, Graïri H, Hamzaoui K
Mediators Inflamm. 2003
PubMed ID: 14514471
Distinct patterns of cleavage and translocation of cell cycle control proteins in CD95-induced and p53-induced apoptosis.
Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
J Korean Med Sci. 2003
PubMed ID: 12923319
Prolonged survival of rat liver allograft with adenoviral gene transfection of human immunodeficiency virus type 1 nef.
Fujino M, Adachi K, Kawasaki M, Kitazawa Y, Funeshima N, Okuyama T, Kimura H, Li XK
Liver Transpl. 2003
PubMed ID: 12884192
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanism.
Blazar BR, Carreno BM, Panoskaltsis-Mortari A, Carter L, Iwai Y, Yagita H, Nishimura H, Taylor PA
J Immunol. 2003
PubMed ID: 12874215
Fas ligand on tumor cells mediates inactivation of neutrophils.
Chen YL, Chen SH, Wang JY, Yang BC
J Immunol. 2003
PubMed ID: 12874204
Involvement of Fas and TNF pathways in the induction of apoptosis of T cells by antithymocyte globulin.
Dubey S, Nityanand S
Ann Hematol. 2003
PubMed ID: 12783210
Necrotic cell death in response to oxidant stress involves the activation of the apoptogenic caspase-8/bid pathway.
Wang X, Ryter SW, Dai C, Tang ZL, Watkins SC, Yin XM, Song R, Choi AM
J Biol Chem. 2003
PubMed ID: 12754217
Regulation of FasL/Fas in human trophoblasts: possible implications for chorioamnionitis.
Balkundi DR, Ziegler JA, Watchko JF, Craven C, Trucco M
Biol Reprod. 2003
PubMed ID: 12700199
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.
Micheau O, Tschopp J
Cell. 2003
PubMed ID: 12887920
Mutation in fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors.
Boursalian TE, Fink PJ
J Exp Med. 2003
PubMed ID: 12860933
A co-evolution perspective of the TNFSF and TNFRSF families in the immune system.
Collette Y, Gilles A, Pontarotti P, Olive D
Trends Immunol. 2003
PubMed ID: 12860530
Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer.
Zheng HC, Sun JM, Wei ZL, Yang XF, Zhang YC, Xin Y
World J Gastroenterol. 2003
PubMed ID: 12854132
Increased retinal neovascularization in Fas ligand-deficient mice.
Davies MH, Eubanks JP, Powers MR
Invest Ophthalmol Vis Sci. 2003
PubMed ID: 12824272
Key apoptotic pathways for heat-induced programmed germ cell death in the testis.
Hikim AP, Lue Y, Yamamoto CM, Vera Y, Rodriguez S, Yen PH, Soeng K, Wang C, Swerdloff RS
Endocrinology. 2003
PubMed ID: 12810573
Regulation of apoptosis by lethal cytokines in human mesothelial cells.
Catalan MP, Subirá D, Reyero A, Selgas R, Ortiz-Gonzalez A, Egido J, Ortiz A
Kidney Int. 2003
PubMed ID: 12787425
Alterations in Fas expression are characteristic of, but not solely responsible for, enhanced metastatic competence.
Liu K, Abrams SI
J Immunol. 2003
PubMed ID: 12794124
CTLA-4. FasL induces alloantigen-specific hyporesponsiveness.
Elhalel MD, Huang JH, Schmidt W, Rachmilewitz J, Tykocinski ML
J Immunol. 2003
PubMed ID: 12794109
Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice.
Freyschmidt-Paul P, McElwee KJ, Botchkarev V, Kissling S, Wenzel E, Sundberg JP, Happle R, Hoffmann R
J Investig Dermatol Symp Proc. 2003
PubMed ID: 12895005
Comparative analysis of apoptosis and inflammation genes of mice and humans.
Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A, RIKEN GER Group, GSL Members
Genome Res. 2003
PubMed ID: 12819136
T-cells mediate an inhibitory effect of interleukin-4 on osteoclastogenesis.
Mirosavljevic D, Quinn JM, Elliott J, Horwood NJ, Martin TJ, Gillespie MT
J Bone Miner Res. 2003
PubMed ID: 12817750
Bcl11b is required for differentiation and survival of alphabeta T lymphocytes.
Wakabayashi Y, Watanabe H, Inoue J, Takeda N, Sakata J, Mishima Y, Hitomi J, Yamamoto T, Utsuyama M, Niwa O, Aizawa S, Kominami R
Nat Immunol. 2003
PubMed ID: 12717433
Apoptosis in uterine epithelium and decidua in response to implantation: evidence for two different pathways.
Joswig A, Gabriel HD, Kibschull M, Winterhager E
Reprod Biol Endocrinol. 2003
PubMed ID: 12801416
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX
J Biol Chem. 2003
PubMed ID: 12637505
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S
Oncogene. 2003
PubMed ID: 12761501
A Bcl-2 transgene expressed in hepatocytes does not protect mice from fulminant liver destruction induced by Fas ligand.
Loo G, Lippens S, Hahne M, Matthijssens F, Declercq W, Saelens X, Vandenabeele P
Cytokine. 2003
PubMed ID: 12849704
Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation.
Legler DF, Micheau O, Doucey MA, Tschopp J, Bron C
Immunity. 2003
PubMed ID: 12753742
The development of clinical activity in relapsing-remitting MS is associated with a decrease of FasL mRNA and an increase of Fas mRNA in peripheral blood.
Lopatinskaya L, van Boxel-Dezaire AH, Barkhof F, Polman CH, Lucas CJ, Nagelkerken L
J Neuroimmunol. 2003
PubMed ID: 12742662
Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis.
Campanelli AP, Martins GA, Souto JT, Pereira MS, Livonesi MC, Martinez R, Silva JS
J Infect Dis. 2003
PubMed ID: 12717632
Toxic epidermal necrolysis and Stevens-Johnson syndrome are induced by soluble Fas ligand.
Abe R, Shimizu T, Shibaki A, Nakamura H, Watanabe H, Shimizu H
Am J Pathol. 2003
PubMed ID: 12707034
Immunohistochemical study of the apoptotic mechanisms in the intestinal mucosa during children's coeliac disease.
Ehrmann J, Kolek A, Kod'ousek R, Zapletalová J, Lísová S, Murray PG, Drábek J, Kolár Z
Virchows Arch. 2003
PubMed ID: 12698366
Endothelial cell overexpression of fas ligand attenuates ischemia-reperfusion injury in the heart.
Yang J, Jones SP, Suhara T, Greer JJ, Ware PD, Nguyen NP, Perlman H, Nelson DP, Lefer DJ, Walsh K
J Biol Chem. 2003
PubMed ID: 12576484
Expression of Fas/Fas-ligand, Bcl-2 protein and apoptosis in extravillous trophoblast along invasion to the decidua in human term placenta.
Murakoshi H, Matsuo H, Laoag-Fernandez JB, Samoto T, Maruo T
Endocr J. 2003
PubMed ID: 12803240
Fas and Fas ligand are associated with neuritic degeneration in the AD brain and participate in beta-amyloid-induced neuronal death.
Su JH, Anderson AJ, Cribbs DH, Tu C, Tong L, Kesslack P, Cotman CW
Neurobiol Dis. 2003
PubMed ID: 12742739
VIPase autoantibodies in Fas-defective mice and patients with autoimmune disease.
Bangale Y, Karle S, Planque S, Zhou YX, Taguchi H, Nishiyama Y, Li L, Kalaga R, Paul S
FASEB J. 2003
PubMed ID: 12665475
Human urinary bladder transitional cell carcinomas acquire the functional Fas ligand during tumor progression.
Chopin D, Barei-Moniri R, Maillé P, Le Frère-Belda MA, Muscatelli-Groux B, Merendino N, Lecerf L, Stoppacciaro A, Velotti F
Am J Pathol. 2003
PubMed ID: 12651606
An unexpected role for FosB in activation-induced cell death of T cells.
Baumann S, Hess J, Eichhorst ST, Krueger A, Angel P, Krammer PH, Kirchhoff S
Oncogene. 2003
PubMed ID: 12618758
Lack of FasL-mediated killing leads to in vivo tumor promotion in mouse Lewis lung cancer.
Lee JK, Sayers TJ, Back TC, Wigginton JM, Wiltrout RH
Apoptosis. 2003
PubMed ID: 12766475
Perforin is required for innate and adaptive immunity induced by heat shock protein gp96.
Strbo N, Oizumi S, Sotosek-Tokmadzic V, Podack ER
Immunity. 2003
PubMed ID: 12648455
Cross-talk between tumor cells and neutrophils through the Fas (APO-1, CD95)/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils.
Hor WS, Huang WL, Lin YS, Yang BC
J Leukoc Biol. 2003
PubMed ID: 12629150
Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis.
Dix RD, Podack ER, Cousins SW
J Virol. 2003
PubMed ID: 12610115
High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis.
Roessner K, Wolfe J, Shi C, Sigal LH, Huber S, Budd RC
J Immunol. 2003
PubMed ID: 12594300
Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease.
Stuck BJ, Pani MA, Besrour F, Segni M, Krause M, Usadel KH, Badenhoop K
Hum Immunol. 2003
PubMed ID: 12559631
Increased bone mass is a part of the generalized lymphoproliferative disorder phenotype in the mouse.
Katavić V, Lukić IK, Kovacić N, Grcević D, Lorenzo JA, Marusić A
J Immunol. 2003
PubMed ID: 12538719
Somatostatin receptor subtype 2 sensitizes human pancreatic cancer cells to death ligand-induced apoptosis.
Guillermet J, Saint-Laurent N, Rochaix P, Cuvillier O, Levade T, Schally AV, Pradayrol L, Buscail L, Susini C, Bousquet C
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12490654
FasL-induced downregulation of CD28 expression on jurkat cells in vitro is associated with activation of caspases.
Ma S, Ochi H, Cui L, He W
Cell Biol Int. 2003
PubMed ID: 14642527
Soluble Fas ligand levels in cerebrospinal fluid in neuro-Behçet's disease.
Aoyama-Hayashi E, Matsuda T, Ohya N, Tanaka C, Kongozi M, Kamo C, Hotta M, Ikejima H, Shiraishi M, Mizushima Y
Adv Exp Med Biol. 2003
PubMed ID: 12918731
Maternal serum of women with pre-eclampsia reduces trophoblast cell viability: evidence for an increased sensitivity to Fas-mediated apoptosis.
Neale D, Demasio K, Illuzi J, Chaiworapongsa T, Romero R, Mor G
J Matern Fetal Neonatal Med. 2003
PubMed ID: 12710855
Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway.
Müller U, Sobek V, Balkow S, Hölscher C, Müllbacher A, Museteanu C, Mossmann H, Simon MM
Eur J Immunol. 2003
PubMed ID: 12594834
Interleukin-4 biases differentiation of B cells from Trypanosoma cruzi-infected mice and restrains their fratricide: role of Fas ligand down-regulation and MHC class II-transactivator up-regulation.
Acosta Rodriguez EV, Zuñiga E, Montes CL, Gruppi A
J Leukoc Biol. 2003
PubMed ID: 12525570
Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer.
Seki N, Hayakawa Y, Brooks AD, Wine J, Wiltrout RH, Yagita H, Tanner JE, Smyth MJ, Sayers TJ
Cancer Res. 2003
PubMed ID: 12517799
Massive hepatic apoptosis associated with TGF-beta1 activation after Fas ligand treatment of IGF binding protein-1-deficient mice.
Leu JI, Crissey MA, Taub R
J Clin Invest. 2003
PubMed ID: 12511596
A novel signaling mechanism for soluble CD95 ligand. Synergy with anti-CD95 monoclonal antibodies for apoptosis and NF-kappaB nuclear translocation.
Xiao S, Jodo S, Sung SS, Marshak-Rothstein A, Ju ST
J Biol Chem. 2002
PubMed ID: 12393889
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells.
Denning TL, Takaishi H, Crowe SE, Boldogh I, Jevnikar A, Ernst PB
Free Radic Biol Med. 2002
PubMed ID: 12488132
Identification of novel matrix metalloproteinase-7 (matrilysin) cleavage sites in murine and human Fas ligand.
Vargo-Gogola T, Crawford HC, Fingleton B, Matrisian LM
Arch Biochem Biophys. 2002
PubMed ID: 12464266
Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion.
Pinkoski MJ, Droin NM, Lin T, Genestier L, Ferguson TA, Green DR
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12454289
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A role for the Fas/Fas ligand apoptotic pathway in regulating myeloid progenitor cell kinetics.
Alenzi FQ, Marley SB, Lewis JL, Chandrashekran A, Warrens AN, Goldman JM, Gordon MY
Exp Hematol. 2002
PubMed ID: 12482505
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
Ayala A, Chung CS, Lomas JL, Song GY, Doughty LA, Gregory SH, Cioffi WG, LeBlanc BW, Reichner J, Simms HH, Grutkoski PS
Am J Pathol. 2002
PubMed ID: 12466142
Bone marrow B cell apoptosis during in vivo influenza virus infection requires TNF-alpha and lymphotoxin-alpha.
Sedger LM, Hou S, Osvath SR, Glaccum MB, Peschon JJ, van Rooijen N, Hyland L
J Immunol. 2002
PubMed ID: 12444124
The human papillomavirus type 16 E5 protein impairs TRAIL- and FasL-mediated apoptosis in HaCaT cells by different mechanisms.
Kabsch K, Alonso A
J Virol. 2002
PubMed ID: 12414956
The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells.
Kaplan MJ, Lewis EE, Shelden EA, Somers E, Pavlic R, McCune WJ, Richardson BC
J Immunol. 2002
PubMed ID: 12421989
FasL deficiency enhances the development of tumors in p53+/- mice.
Embree-Ku M, Boekelheide K
Toxicol Pathol. 2002
PubMed ID: 12512872
Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome.
Albertine KH, Soulier MF, Wang Z, Ishizaka A, Hashimoto S, Zimmerman GA, Matthay MA, Ware LB
Am J Pathol. 2002
PubMed ID: 12414525
Synergistic engagement of an ineffective endogenous anti-tumor immune response and induction of IFN-gamma and Fas-ligand-dependent tumor eradication by combined administration of IL-18 and IL-2.
Wigginton JM, Lee JK, Wiltrout TA, Alvord WG, Hixon JA, Subleski J, Back TC, Wiltrout RH
J Immunol. 2002
PubMed ID: 12370382
Bax, Bcl-2, fas and Fas-L antigen expression in human seminoma: correlation with the apoptotic index.
Grobholz R, Zentgraf H, Köhrmann KU, Bleyl U
APMIS. 2002
PubMed ID: 12583439
Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels.
Bouchet D, Tesson L, Ménoret S, Charreau B, Mathieu P, Yagita H, Duisit G, Anegon I
Mol Med. 2002
PubMed ID: 12477972
Prognostic significance of a combination of soluble Fas and soluble Fas ligand in the serum of patients with Ta bladder cancer.
Mizutani Y, Yoshida O, Ukimura O, Kawauchi A, Bonavida B, Miki T
Cancer Biother Radiopharm. 2002
PubMed ID: 12470426
Fas ligand breaks tolerance to self-antigens and induces tumor immunity mediated by antibodies.
Simon AK, Gallimore A, Jones E, Sawitzki B, Cerundolo V, Screaton GR
Cancer Cell. 2002
PubMed ID: 12398895
Elevated soluble Fas ligand levels may suggest a role for apoptosis in women with endometriosis.
Garcia-Velasco JA, Mulayim N, Kayisli UA, Arici A
Fertil Steril. 2002
PubMed ID: 12372468
Fas and Fas ligand expression in pancreatic adenocarcinoma.
Pernick NL, Sarkar FH, Tabaczka P, Kotcher G, Frank J, Adsay NV
Pancreas. 2002
PubMed ID: 12370548
Toll-like receptor 2 contributes to liver injury by Salmonella infection through Fas ligand expression on NKT cells in mice.
Shimizu H, Matsuguchi T, Fukuda Y, Nakano I, Hayakawa T, Takeuchi O, Akira S, Umemura M, Suda T, Yoshikai Y
Gastroenterology. 2002
PubMed ID: 12360487
The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B.
Conlan LA, Martin TJ, Gillespie MT
FEBS Lett. 2002
PubMed ID: 12220636
Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.
Li-Weber M, Weigand MA, Giaisi M, Süss D, Treiber MK, Baumann S, Ritsou E, Breitkreutz R, Krammer PH
J Clin Invest. 2002
PubMed ID: 12208869
Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-gamma and is independent of perforin and granzymes.
Sobek V, Balkow S, Körner H, Simon MM
Eur J Immunol. 2002
PubMed ID: 12207333
Hyperosmolarity triggers CD95 membrane trafficking and sensitizes rat hepatocytes toward CD95L-induced apoptosis.
Reinehr R, Graf D, Fischer R, Schliess F, Häussinger D
Hepatology. 2002
PubMed ID: 12198652
Membrane Fas ligand activates innate immunity and terminates ocular immune privilege.
Gregory MS, Repp AC, Holhbaum AM, Saff RR, Marshak-Rothstein A, Ksander BR
J Immunol. 2002
PubMed ID: 12193747
Cutting edge: a novel role for Fas ligand in facilitating antigen acquisition by dendritic cells.
Tada Y, O-Wang J, Takiguchi Y, Tatsumi K, Kuriyama T, Okada S, Tokuhisa T, Sakiyama S, Tagawa M
J Immunol. 2002
PubMed ID: 12193688
Extensive and preferential Fas/Fas ligand-dependent death of gammadelta T cells following infection with Listeria monocytogenes.
Mukasa A, Lahn M, Fleming S, Freiberg B, Pflum E, Vollmer M, Kupfer A, O'Brien R, Born W
Scand J Immunol. 2002
PubMed ID: 12193224
Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.
Kojima Y, Kawasaki-Koyanagi A, Sueyoshi N, Kanai A, Yagita H, Okumura K
Biochem Biophys Res Commun. 2002
PubMed ID: 12163021
Possible involvement of Fas system in the induction of apoptosis in human astrocytic brain tumors.
Fujita H, Koji T, Kitagawa N, Tsutsumi K, Abe K, Kaminogo M, Shibata S
Cell Mol Neurobiol. 2002
PubMed ID: 12507389
Regulation of fas ligand expression by IL-8 in human endometrium.
Selam B, Kayisli UA, Garcia-Velasco JA, Akbas GE, Arici A
J Clin Endocrinol Metab. 2002
PubMed ID: 12161534
Inflammatory signals increase Fas ligand expression by inner ear cells.
Bodmer D, Brors D, Pak K, Keithley EM, Mullen L, Ryan AF, Gloddek B
J Neuroimmunol. 2002
PubMed ID: 12161015
MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.
VanLith ML, Kohlgraf KG, Sivinski CL, Tempero RM, Hollingsworth MA
Int Immunol. 2002
PubMed ID: 12147624
The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo.
Ford MS, Young KJ, Zhang Z, Ohashi PS, Zhang L
J Exp Med. 2002
PubMed ID: 12119351
H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP.
Facchinetti F, Furegato S, Terrazzino S, Leon A
J Neurosci Res. 2002
PubMed ID: 12111799
Constitutive expression of the Fas receptor and its ligand in adult human bone marrow: a regulatory feedback loop for the homeostatic control of hematopoiesis.
Brazil JJ, Gupta P
Blood Cells Mol Dis. 2002
PubMed ID: 12482410
Role of Fas/Fas ligand interaction in ischemia-induced collateral vessel growth.
Sata M, Hirata Y, Nagai R
Hypertens Res. 2002
PubMed ID: 12358144
Absence of weight loss during Cryptosporidium infection in susceptible mice deficient in Fas-mediated apoptosis.
Motta I, Gissot M, Kanellopoulos JM, Ojcius DM
Microbes Infect. 2002
PubMed ID: 12270729
Regulation of Fas ligand expression by estrogen in normal ovary.
Sapi E, Brown WD, Aschkenazi S, Lim C, Munoz A, Kacinski BM, Rutherford T, Mor G
J Soc Gynecol Investig. 2002
PubMed ID: 12113885
Abnormal expression and function of Fas ligand of lacrimal glands and peripheral blood in Sjögren's syndrome patients with enlarged exocrine glands.
Tsubota K, Fujita H, Tadano K, Onoda N, Tsuzaka K, Takeuchi T
Clin Exp Immunol. 2002
PubMed ID: 12100038
Absence of p53 and FasL has sexually dimorphic effects on both development and reproduction.
Embree-Ku M, Boekelheide K
Exp Biol Med (Maywood). 2002
PubMed ID: 12094020
Gammadelta T cells promote a Th1 response during coxsackievirus B3 infection in vivo: role of Fas and Fas ligand.
Huber S, Shi C, Budd RC
J Virol. 2002
PubMed ID: 12050361
Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis.
Wang W, Prince CZ, Mou Y, Pollman MJ
J Biol Chem. 2002
PubMed ID: 11925448
[Study on expression and function of fas ligand in human myeloid leukemia cells]
Li AX, Zou P, Wang LL, Hu ZB, Ma YP
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2002
PubMed ID: 12513781
[The role of Fas/Fas ligand in tumorgenesis, immune escape, and counterattack in colonic cancer]
Zhu Q, Deng C
Zhonghua Nei Ke Za Zhi. 2002
PubMed ID: 12137598
Redundant and alternative roles for activating Fc receptors and complement in an antibody-dependent model of autoimmune vitiligo.
Trcka J, Moroi Y, Clynes RA, Goldberg SM, Bergtold A, Perales MA, Ma M, Ferrone CR, Carroll MC, Ravetch JV, Houghton AN
Immunity. 2002
PubMed ID: 12121667
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.
Crawford HC, Scoggins CR, Washington MK, Matrisian LM, Leach SD
J Clin Invest. 2002
PubMed ID: 12045257
Differential regulation and function of the Fas/Fas ligand system in human trophoblast cells.
Aschkenazi S, Straszewski S, Verwer KM, Foellmer H, Rutherford T, Mor G
Biol Reprod. 2002
PubMed ID: 12021072
HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter.
Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD
J Biol Chem. 2002
PubMed ID: 11909874
Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178).
Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O
FEBS Lett. 2002
PubMed ID: 12023017
Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles.
Andreola G, Rivoltini L, Castelli C, Huber V, Perego P, Deho P, Squarcina P, Accornero P, Lozupone F, Lugini L, Stringaro A, Molinari A, Arancia G, Gentile M, Parmiani G, Fais S
J Exp Med. 2002
PubMed ID: 12021310
Modulation of dendritic cell differentiation and maturation by decoy receptor 3.
Hsu TL, Chang YC, Chen SJ, Liu YJ, Chiu AW, Chio CC, Chen L, Hsieh SL
J Immunol. 2002
PubMed ID: 11994433
[Fas and Fas-L expression in human adenocarcinoma of uterine cervix]
Chen B, Shi Y, Ge Y, Zhou C, Chen X
Zhonghua Zhong Liu Za Zhi. 2002
PubMed ID: 12515623
Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells.
Song J, Rutherford T, Naftolin F, Brown S, Mor G
Mol Hum Reprod. 2002
PubMed ID: 11994542
IL-10 is necessary for FasL-induced protection from experimental autoimmune thyroiditis but not for FasL-induced immune deviation.
Tourneur L, Damotte D, Marion S, Mistou S, Chiocchia G
Eur J Immunol. 2002
PubMed ID: 11981816
Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism.
Miñana JB, Gómez-Cambronero L, Lloret A, Pallardó FV, Del Olmo J, Escudero A, Rodrigo JM, Pellíin A, Viña JR, Viña J, Sastre J
Hepatology. 2002
PubMed ID: 11981771
c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction.
Couillard M, Guillaume R, Tanji N, D'Agati V, Trudel M
Cancer Res. 2002
PubMed ID: 11956070
Role of p38 mitogen-activated protein kinase phosphorylation and Fas-Fas ligand interaction in morphine-induced macrophage apoptosis.
Singhal PC, Bhaskaran M, Patel J, Patel K, Kasinath BS, Duraisamy S, Franki N, Reddy K, Kapasi AA
J Immunol. 2002
PubMed ID: 11937560
Normal breast epithelial cells induce apoptosis of breast cancer cells via Fas signaling.
Toillon RA, Descamps S, Adriaenssens E, Ricort JM, Bernard D, Boilly B, Le Bourhis X
Exp Cell Res. 2002
PubMed ID: 11925103
Apoptosis and related proteins during parturition in prostaglandin F receptor-deficient mice.
Mu J, Kanzaki T, Si X, Tomimatsu T, Fukuda H, Fujii E, Hosono T, Murata Y, Sugimoto Y, Ichikawa A
Biochem Biophys Res Commun. 2002
PubMed ID: 11922619
Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase.
Dermitzaki E, Tsatsanis C, Gravanis A, Margioris AN
J Biol Chem. 2002
PubMed ID: 11790788
Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: studies on centenarians.
Pinti M, Troiano L, Nasi M, Moretti L, Monterastelli E, Mazzacani A, Mussi C, Ventura P, Olivieri F, Franceschi C, Salvioli G, Cossarizza A
Cell Death Differ. 2002
PubMed ID: 11965496
Differential expressions of Fas and Fas ligand in human placenta.
Roh CR, Lee JW, Kang BH, Yang SH, Kim BG, Bae DS, Kim JH, Lee JH
J Korean Med Sci. 2002
PubMed ID: 11961305
Apoptosis and expression of apoptosis-related genes in the mouse testis following heat exposure.
Miura M, Sasagawa I, Suzuki Y, Nakada T, Fujii J
Fertil Steril. 2002
PubMed ID: 11937135
Lack of both Fas ligand and perforin protects from flavivirus-mediated encephalitis in mice.
Licon Luna RM, Lee E, Müllbacher A, Blanden RV, Langman R, Lobigs M
J Virol. 2002
PubMed ID: 11884544
Granzyme B, FAS-ligand and perforin expression during acute cellular rejection episodes after kidney transplantation: comparison between blood and renal aspirates.
Netto MV, Fonseca BA, Dantas M, Saber LT, Castro MC, Ferraz AS
Transplant Proc. 2002
PubMed ID: 12009596
Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes/macrophage.
Imanishi T, Han DK, Hofstra L, Hano T, Nishio I, Liles WC, Gown AM, Schwartz SM, Han DK, Gorden AM
Atherosclerosis. 2002
PubMed ID: 11882326
T cell dependent and independent antitumor immunity generated by the expression of Fas ligand on mouse lung carcinoma cells.
Tada Y, O-Wang J, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
Int J Mol Med. 2002
PubMed ID: 11836634
Negative regulation of erythroblast maturation by Fas-L(+)/TRAIL(+) highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma.
Silvestris F, Cafforio P, Tucci M, Dammacco F
Blood. 2002
PubMed ID: 11830480
Repression of FasL expression by retinoic acid involves a novel mechanism of inhibition of transactivation function of the nuclear factors of activated T-cells.
Lee MO, Kang HJ, Kim YM, Oum JH, Park J
Eur J Biochem. 2002
PubMed ID: 11856352
Evolution of the regulators of G-protein signaling multigene family in mouse and human.
Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM
Genomics. 2002
PubMed ID: 11829488
Fas (CD95/Apo-1)/Fas ligand expression in neonates with pontosubicular neuron necrosis.
van Landeghem FK, Felderhoff-Mueser U, Moysich A, Stadelmann C, Obladen M, Brück W, Bührer C
Pediatr Res. 2002
PubMed ID: 11809905
Negative regulation of CD95 ligand gene expression by vitamin D3 in T lymphocytes.
Cippitelli M, Fionda C, Di Bona D, Di Rosa F, Lupo A, Piccoli M, Frati L, Santoni A
J Immunol. 2002
PubMed ID: 11801650
Expression of Fas and Fas ligand in esophageal tissue mucosa and carcinomas.
Kase S, Osaki M, Adachi H, Kaibara N, Ito H
Int J Oncol. 2002
PubMed ID: 11788891
Fas (Apo-1/CD95) and Fas ligand interaction between gastric cancer cells and immune cells.
Lee TB, Min YD, Lim SC, Kim KJ, Jeon HJ, Choi SM, Choi CH
J Gastroenterol Hepatol. 2002
PubMed ID: 11895550
Porcine Fas-ligand gene: genomic sequence analysis and comparison with human gene.
Motegi-Ishiyama Y, Nakajima Y, Hoka S, Takagaki Y
Mol Immunol. 2002
PubMed ID: 11792426
Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.
Chopin V, Toillon RA, Jouy N, Le Bourhis X
Br J Pharmacol. 2002
PubMed ID: 11786482
Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver.
Rüdiger HA, Clavien PA
Gastroenterology. 2002
PubMed ID: 11781294
Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection.
Zhou S, Ou R, Huang L, Moskophidis D
J Virol. 2002
PubMed ID: 11752172
Extracellular matrix-dependent regulation of Fas ligand expression in human endometrial stromal cells.
Selam B, Kayisli UA, Garcia-Velasco JA, Arici A
Biol Reprod. 2002
PubMed ID: 11751256
Expression of FasL gene in T cells of renal allograft recipients.
Kasprzycka M, Kłodos K, Nowaczyk M, Wyzgał J, Podobińska I, Durlik M, Górski A
Immunol Lett. 2002
PubMed ID: 11716959
Genetic contributions of nonautoimmune SWR mice toward lupus nephritis.
Xie S, Chang S, Yang P, Jacob C, Kaliyaperumal A, Datta SK, Mohan C
J Immunol. 2001
PubMed ID: 11739537
Differential secretion of Fas ligand- or APO2 ligand/TNF-related apoptosis-inducing ligand-carrying microvesicles during activation-induced death of human T cells.
Monleón I, Martínez-Lorenzo MJ, Monteagudo L, Lasierra P, Taulés M, Iturralde M, Piñeiro A, Larrad L, Alava MA, Naval J, Anel A
J Immunol. 2001
PubMed ID: 11739488
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O
FEBS Lett. 2001
PubMed ID: 11741599
Expression and regulation of Fas and Fas ligand on thyrocytes and infiltrating cells during induction and resolution of granulomatous experimental autoimmune thyroiditis.
Wei Y, Chen K, Sharp GC, Yagita H, Braley-Mullen H
J Immunol. 2001
PubMed ID: 11714840
Liver damage by infiltrating CD8+ T cells is Fas dependent.
Kennedy NJ, Russell JQ, Michail N, Budd RC
J Immunol. 2001
PubMed ID: 11714837
Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells.
Jung YS, Kim KS, Kim KD, Lim JS, Kim JW, Kim E
Biochem Biophys Res Commun. 2001
PubMed ID: 11606059
Identification of a polymorphic microsatellite marker in the mouse Fas ligand gene.
Lévi-Strauss M, Beauvais C, Karray S
Eur J Immunogenet. 2001
PubMed ID: 11881823
The role of the Fas/Fas ligand system in estrogen-induced thymic alteration.
Mor G, Muñoz A, Redlinger R, Silva I, Song J, Lim C, Kohen F
Am J Reprod Immunol. 2001
PubMed ID: 11642679
Effect of Fas and Fas ligand deficiency in resistance of C57BL/6 mice to HSV-1 keratitis and chorioretinitis.
Nguyen QD, Uy HS, Merchant A, Medina CA, Baltatzis S, Zhao T, Zhao ZS, Cantor H, Foster CS
Invest Ophthalmol Vis Sci. 2001
PubMed ID: 11581190
Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.
Morishima Y, Gotoh Y, Zieg J, Barrett T, Takano H, Flavell R, Davis RJ, Shirasaki Y, Greenberg ME
J Neurosci. 2001
PubMed ID: 11567045
Castration induces apoptosis in the male accessory sex organs of Fas-deficient lpr and Fas ligand-deficient gld mutant mice.
Sugihara A, Yamada N, Tsujimura T, Iwasaki T, Yamashita K, Takagi Y, Tsuji M, Terada N
In Vivo. 2001
PubMed ID: 11695234
Inhibition of NF-kappaB in T cells blocks lymphoproliferation and partially rescues autoimmune disease in gld/gld mice.
Vallabhapurapu S, Ryseck RP, Malewicz M, Weih DS, Weih F
Eur J Immunol. 2001
PubMed ID: 11536159
Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection.
Balkow S, Kersten A, Tran TT, Stehle T, Grosse P, Museteanu C, Utermöhlen O, Pircher H, von Weizsäcker F, Wallich R, Müllbacher A, Simon MM
J Virol. 2001
PubMed ID: 11507223
Fas/Fas ligand deficiency results in altered localization of anti-double-stranded DNA B cells and dendritic cells.
Fields ML, Sokol CL, Eaton-Bassiri A, Seo S, Madaio MP, Erikson J
J Immunol. 2001
PubMed ID: 11490027
Genetic influences on the end-stage effector phase of arthritis.
Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon HJ, Degott C, Lathrop M, Benoist C, Mathis D
J Exp Med. 2001
PubMed ID: 11489951
The genes encoding E-selectin (SELE) and lymphotactin (SCYC1) lie on separate chicken chromosomes although they are closely linked in human and mouse.
Morroll S, Goodchild M, Salmon N, Copeland NG, Gilbert DJ, Jenkins NA, Bumstead N, Boyd Y
Immunogenetics. 2001
PubMed ID: 11685458
The membrane-bound but not the soluble form of human Fas ligand is responsible for its inflammatory activity.
Shudo K, Kinoshita K, Imamura R, Fan H, Hasumoto K, Tanaka M, Nagata S, Suda T
Eur J Immunol. 2001
PubMed ID: 11500835
Transgenic expression of CD95 ligand on thyroid follicular cells confers immune privilege upon thyroid allografts.
Tourneur L, Malassagne B, Batteux F, Fabre M, Mistou S, Lallemand E, Lores P, Chiocchia G
J Immunol. 2001
PubMed ID: 11466351
Fas ligand triggers pulmonary silicosis.
Borges VM, Falcão H, Leite-Júnior JH, Alvim L, Teixeira GP, Russo M, Nóbrega AF, Lopes MF, Rocco PM, Davidson WF, Linden R, Yagita H, Zin WA, DosReis GA
J Exp Med. 2001
PubMed ID: 11457890
Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity.
Medana I, Li Z, Flügel A, Tschopp J, Wekerle H, Neumann H
J Immunol. 2001
PubMed ID: 11441070
Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail.
Blott EJ, Bossi G, Clark R, Zvelebil M, Griffiths GM
J Cell Sci. 2001
PubMed ID: 11559749
Control of murine cytomegalovirus replication in salivary glands during acute infection is independent of the Fas ligand/Fas system.
Riera L, Gariglio M, Pagano M, Gaiola O, Simon MM, Landolfo S
New Microbiol. 2001
PubMed ID: 11497079
IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy.
Wigginton JM, Gruys E, Geiselhart L, Subleski J, Komschlies KL, Park JW, Wiltrout TA, Nagashima K, Back TC, Wiltrout RH
J Clin Invest. 2001
PubMed ID: 11435457
Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis.
Zayas MD, Lucas M, Solano F, Fernández-Pérez MJ, Izquierdo G
J Neuroimmunol. 2001
PubMed ID: 11438180
Mechanisms of the antimetastatic effect in the liver and of the hepatocyte injury induced by alpha-galactosylceramide in mice.
Nakagawa R, Nagafune I, Tazunoki Y, Ehara H, Tomura H, Iijima R, Motoki K, Kamishohara M, Seki S
J Immunol. 2001
PubMed ID: 11359810
Antigen-specific T(h)1 cells as direct effectors of Propionibacterium acnes-primed lipopolysaccharide-induced hepatic injury.
Okazaki T, Ozaki S, Nagaoka T, Kozuki M, Sumita S, Tanaka M, Osakada F, Kishimura M, Kakutani T, Nakao K
Int Immunol. 2001
PubMed ID: 11312248
Increased apoptosis in lamina propria B cells during polymicrobial sepsis is FasL but not endotoxin mediated.
Chung CS, Wang W, Chaudry IH, Ayala A
Am J Physiol Gastrointest Liver Physiol. 2001
PubMed ID: 11292588
The role of Fas system [Fas-FasL] as an inducer of apoptosis in cutaneous leishmaniasis: a combined human and experimental study.
el-Kowrany SI, Sallam FA, Nassar SO, Ismail HI, Eissa MM
J Egypt Soc Parasitol. 2001
PubMed ID: 12557947
CD95 is required for the early control of parasite burden in the liver of Leishmania donovani-infected mice.
Alexander CE, Kaye PM, Engwerda CR
Eur J Immunol. 2001
PubMed ID: 11298345
Extracellular matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity.
Aoki K, Kurooka M, Chen JJ, Petryniak J, Nabel EG, Nabel GJ
Nat Immunol. 2001
PubMed ID: 11276204
Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members.
Dzialo-Hatton R, Milbrandt J, Hockett RD, Weaver CT
J Immunol. 2001
PubMed ID: 11254710
Veto activity of activated bone marrow does not require perforin and Fas ligand.
Chrobak P, Gress RE
Cell Immunol. 2001
PubMed ID: 11333140
Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway.
Melnick M, Chen H, Zhou Y, Jaskoll T
Anat Rec. 2001
PubMed ID: 11241200
The TNF and TNF receptor superfamilies: integrating mammalian biology.
Locksley RM, Killeen N, Lenardo MJ
Cell. 2001
PubMed ID: 11239407
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation.
Kapasi AA, Fan S, Singhal PC
Am J Physiol Renal Physiol. 2001
PubMed ID: 11208609
CD8- and CD95/95L-dependent mechanisms of resistance in mice with chronic pulmonary tuberculosis.
Turner J, D'Souza CD, Pearl JE, Marietta P, Noel M, Frank AA, Appelberg R, Orme IM, Cooper AM
Am J Respir Cell Mol Biol. 2001
PubMed ID: 11159055
Modulation of fas/fasL in a murine retroviral infection by AZT and methionine enkephalin.
Bowden R, Soto S, Specter S
Adv Exp Med Biol. 2001
PubMed ID: 11727760
Human pancreatic cancer cells express non-functional Fas receptors and counterattack lymphocytes by expressing Fas ligand; a potential mechanism for immune escape.
Elnemr A, Ohta T, Yachie A, Kayahara M, Kitagawa H, Ninomiya I, Fushida S, Fujimura T, Nishimura G, Shimizu K, Miwa K
Int J Oncol. 2001
PubMed ID: 11115536
Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice.
Mitsos LM, Cardon LR, Fortin A, Ryan L, LaCourse R, North RJ, Gros P
Genes Immun. 2000
PubMed ID: 11197687
Loss of Fas-ligand expression in mouse keratinocytes during UV carcinogenesis.
Ouhtit A, Gorny A, Muller HK, Hill LL, Owen-Schaub L, Ananthaswamy HN
Am J Pathol. 2000
PubMed ID: 11106570
Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.
Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, Bodmer JL, Schneider P, Seed B, Tschopp J
Nat Immunol. 2000
PubMed ID: 11101870
Pathogenesis of herpes simplex virus type 1-induced corneal inflammation in perforin-deficient mice.
Chang E, Galle L, Maggs D, Estes DM, Mitchell WJ
J Virol. 2000
PubMed ID: 11090183
Fas and Fas ligand expressed on cells of the immune system, not on the target tissue, control induction of experimental autoimmune uveitis.
Wahlsten JL, Gitchell HL, Chan CC, Wiggert B, Caspi RR
J Immunol. 2000
PubMed ID: 11067900
Roles of Fas and Fas ligand during mammary gland remodeling.
Song J, Sapi E, Brown W, Nilsen J, Tartaro K, Kacinski BM, Craft J, Naftolin F, Mor G
J Clin Invest. 2000
PubMed ID: 11086022
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Host T cells resist graft-versus-host disease mediated by donor leukocyte infusions.
Blazar BR, Lees CJ, Martin PJ, Noelle RJ, Kwon B, Murphy W, Taylor PA
J Immunol. 2000
PubMed ID: 11046015
Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis.
Smith AL, Hayday AC
Infect Immun. 2000
PubMed ID: 11035735
Expression of Fas and Fas ligand reflects the biological characteristics but not the status of apoptosis of intrahepatic cholangiocellular carcinoma.
Ito Y, Takeda T, Sasaki Y, Sakon M, Yamada T, Ishiguro S, Imaoka S, Tsujimoto M, Matsuura N
Int J Mol Med. 2000
PubMed ID: 11029528
Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice.
Melamed D, Miri E, Leider N, Nemazee D
J Immunol. 2000
PubMed ID: 11035071
The biochemistry of apoptosis.
Hengartner MO
Nature. 2000
PubMed ID: 11048727
CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway.
Parlato S, Giammarioli AM, Logozzi M, Lozupone F, Matarrese P, Luciani F, Falchi M, Malorni W, Fais S
EMBO J. 2000
PubMed ID: 11013215
apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene.
Feuk L, Prince JA, Breen G, Emahazion T, Carothers A, St Clair D, Brookes AJ
Hum Genet. 2000
PubMed ID: 11129341
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome.
Bolstad AI, Wargelius A, Nakken B, Haga HJ, Jonsson R
J Rheumatol. 2000
PubMed ID: 11036836
Evidence that retinal pigment epithelium functions as an immune-privileged tissue.
Wenkel H, Streilein JW
Invest Ophthalmol Vis Sci. 2000
PubMed ID: 11006240
Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks.
Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A
J Exp Med. 2000
PubMed ID: 10993919
Interferon-gamma is required for innate immunity to Cryptosporidium parvum in mice.
Hayward AR, Chmura K, Cosyns M
J Infect Dis. 2000
PubMed ID: 10950807
Fas engagement accelerates liver regeneration after partial hepatectomy.
Desbarats J, Newell MK
Nat Med. 2000
PubMed ID: 10932231
Immune complexes present in the sera of autoimmune mice activate rheumatoid factor B cells.
Rifkin IR, Leadbetter EA, Beaudette BC, Kiani C, Monestier M, Shlomchik MJ, Marshak-Rothstein A
J Immunol. 2000
PubMed ID: 10903773
Fas ligand-deficient mice display enhanced leukocyte infiltration and intima hyperplasia in flow-restricted vessels.
Sata M, Walsh K
J Mol Cell Cardiol. 2000
PubMed ID: 10900166
Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease.
van den Brink MR, Moore E, Horndasch KJ, Crawford JM, Murphy GF, Burakoff SJ
Transplantation. 2000
PubMed ID: 10919598
Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus.
Satoh M, Weintraub JP, Yoshida H, Shaheen VM, Richards HB, Shaw M, Reeves WH
J Immunol. 2000
PubMed ID: 10878381
Requirement for RORgamma in thymocyte survival and lymphoid organ development.
Sun Z, Unutmaz D, Zou YR, Sunshine MJ, Pierani A, Brenner-Morton S, Mebius RE, Littman DR
Science. 2000
PubMed ID: 10875923
Double mutant MRL-lpr/lpr-gld/gld cells fail to trigger lpr-graft-versus-host disease in syngeneic wild-type recipient mice, but can induce wild-type B cells to make autoantibody.
Zhu B, Beaudette BC, Rifkin IR, Marshak-Rothstein A
Eur J Immunol. 2000
PubMed ID: 10898516
Engagement of CD4 before TCR triggering regulates both Bax- and Fas (CD95)-mediated apoptosis.
Somma F, Tuosto L, Gilardini Montani MS, Di Somma MM, Cundari E, Piccolella E
J Immunol. 2000
PubMed ID: 10799864
Critical contribution of liver natural killer T cells to a murine model of hepatitis.
Takeda K, Hayakawa Y, Van Kaer L, Matsuda H, Yagita H, Okumura K
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10792025
CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types.
O'Connor L, Harris AW, Strasser A
Cancer Res. 2000
PubMed ID: 10728678
Antigen presenting cells expressing Fas ligand down-modulate chronic inflammatory disease in Fas ligand-deficient mice.
Zhang HG, Fleck M, Kern ER, Liu D, Wang Y, Hsu HC, Yang P, Wang Z, Curiel DT, Zhou T, Mountz JD
J Clin Invest. 2000
PubMed ID: 10727450
Fas and Fas ligand in gut and liver.
Pinkoski MJ, Brunner T, Green DR, Lin T
Am J Physiol Gastrointest Liver Physiol. 2000
PubMed ID: 10712254
Molecular characterization of the mouse Fas ligand promoter in airway epithelial cells.
Zhang J, Miranda K, Ma BY, Fine A
Biochim Biophys Acta. 2000
PubMed ID: 10684974
Transgenic expression of Fas ligand on thyroid follicular cells prevents autoimmune thyroiditis.
Batteux F, Lores P, Bucchini D, Chiocchia G
J Immunol. 2000
PubMed ID: 10657610
T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.
Li-Weber M, Laur O, Dern K, Krammer PH
Eur J Immunol. 2000
PubMed ID: 10671224
Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype.
Körner H, Cretney E, Wilhelm P, Kelly JM, Röllinghoff M, Sedgwick JD, Smyth MJ
J Exp Med. 2000
PubMed ID: 10620607
Fas ligand is expressed in normal breast epithelial cells and is frequently up-regulated in breast cancer.
Müllauer L, Mosberger I, Grusch M, Rudas M, Chott A
J Pathol. 2000
PubMed ID: 10640988
Ionizing radiation alters Fas antigen ligand at the cell surface and on exfoliated plasma membrane-derived vesicles: implications for apoptosis and intercellular signaling.
Albanese J, Dainiak N
Radiat Res. 2000
PubMed ID: 10630977
Coupling and uncoupling of tumor immunity and autoimmunity.
Bowne WB, Srinivasan R, Wolchok JD, Hawkins WG, Blachere NE, Dyall R, Lewis JJ, Houghton AN
J Exp Med. 1999
PubMed ID: 10587362
Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice.
Taguchi N, Hashimoto Y, Naiki M, Farr AG, Boyd RL, Ansari AA, Shultz LD, Kotzin BL, Dorshkind K, Ikehara S, Gershwin ME
J Autoimmun. 1999
PubMed ID: 10585755
Cloning and expression of a short Fas ligand: A new alternatively spliced product of the mouse Fas ligand gene.
Ayroldi E, D'Adamio F, Zollo O, Agostini M, Moraca R, Cannarile L, Migliorati G, Delfino DV, Riccardi C
Blood. 1999
PubMed ID: 10552956
Gender- and androgen-related influence on the expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice.
Toda I, Sullivan BD, Wickham LA, Sullivan DA
J Steroid Biochem Mol Biol. 1999
PubMed ID: 10619357
Apoptosis and the thymic microenvironment in murine lupus.
Takeoka Y, Taguchi N, Shultz L, Boyd RL, Naiki M, Ansari AA, Gershwin ME
J Autoimmun. 1999
PubMed ID: 10550220
Fas ligand is frequently expressed in human pancreatic duct cell carcinoma.
Satoh K, Shimosegawa T, Masamune A, Hirota M, Koizumi M, Toyota T
Pancreas. 1999
PubMed ID: 10547193
Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD)-induced immunotoxicity: increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity.
Kamath AB, Camacho I, Nagarkatti PS, Nagarkatti M
Toxicol Appl Pharmacol. 1999
PubMed ID: 10527913
Increased fetal and extramedullary hematopoiesis in Fas-deficient C57BL/6-lpr/lpr mice.
Schneider E, Moreau G, Arnould A, Vasseur F, Khodabaccus N, Dy M, Ezine S
Blood. 1999
PubMed ID: 10515865
Effect of graft-versus-host disease (GVHD) on host hematopoietic progenitor cells is mediated by Fas-Fas ligand interactions but this does not explain the effect of GVHD on donor cells.
Iwasaki T, Hamano T, Saheki K, Kuroiwa T, Kataoka Y, Takemoto Y, Ogata A, Sugihara A, Terada N, Fujimoto J, Kakishita E
Cell Immunol. 1999
PubMed ID: 10555993
IL-5 mediates eosinophilic rejection of MHC class II-disparate skin allografts in mice.
Le Moine A, Surquin M, Demoor FX, Noël JC, Nahori MA, Pretolani M, Flamand V, Braun MY, Goldman M, Abramowicz D
J Immunol. 1999
PubMed ID: 10490975
Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ T cells in vivo.
Maldonado MA, MacDonald GC, Kakkanaiah VN, Fecho K, Dransfield M, Sekiguchi D, Cohen PL, Eisenberg RA
J Immunol. 1999
PubMed ID: 10477580
Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice.
Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, Matsui K, Kashiwamura S, Hada T, Akira S, Yagita H, Okamura H, Nakanishi K
Immunity. 1999
PubMed ID: 10514014
Cytokine deprivation of naive CD8+ T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: a mechanism of self-regulation.
Sad S, Krishnan L
J Immunol. 1999
PubMed ID: 10452979
Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells.
Urtreger AJ, Aguirre Ghiso JA, Werbajh SE, Puricelli LI, Muro AF, Bal de Kier Joff E
Int J Cancer. 1999
PubMed ID: 10417775
Fas ligand: a sensor for DNA damage critical in skin cancer etiology.
Hill LL, Ouhtit A, Loughlin SM, Kripke ML, Ananthaswamy HN, Owen-Schaub LB
Science. 1999
PubMed ID: 10436160
Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice.
Smyth MJ, Johnstone RW, Cretney E, Haynes NM, Sedgwick JD, Korner H, Poulton LD, Baxter AG
J Immunol. 1999
PubMed ID: 10415034
Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively.
Hashimoto W, Osaki T, Okamura H, Robbins PD, Kurimoto M, Nagata S, Lotze MT, Tahara H
J Immunol. 1999
PubMed ID: 10395644
Another cell death induction system: TNF-alpha acts as a ligand for Fas in vaginal cells.
Suzuki A, Tsutomi Y, Shimizu M, Matsuzawa A
Cell Death Differ. 1999
PubMed ID: 10453074
Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis.
Kuwano K, Hagimoto N, Kawasaki M, Yatomi T, Nakamura N, Nagata S, Suda T, Kunitake R, Maeyama T, Miyazaki H, Hara N
J Clin Invest. 1999
PubMed ID: 10393694
Ectopic expression of B7-1 (CD80) on T lymphocytes in autoimmune lpr and gld mice.
Weintraub JP, Cohen PL
Clin Immunol. 1999
PubMed ID: 10370375
Perforin is a major contributor to NK cell control of tumor metastasis.
Smyth MJ, Thia KY, Cretney E, Kelly JM, Snook MB, Forbes CA, Scalzo AA
J Immunol. 1999
PubMed ID: 10352283
Evidence for Fas-dependent and Fas-independent mechanisms in the pathogenesis of experimental autoimmune encephalomyelitis.
Dittel BN, Merchant RM, Janeway CA
J Immunol. 1999
PubMed ID: 10352252
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.
Yu KY, Kwon B, Ni J, Zhai Y, Ebner R, Kwon BS
J Biol Chem. 1999
PubMed ID: 10318773
Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.
Xu XN, Laffert B, Screaton GR, Kraft M, Wolf D, Kolanus W, Mongkolsapay J, McMichael AJ, Baur AS
J Exp Med. 1999
PubMed ID: 10224289
Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice.
Bachmann R, Eugster HP, Frei K, Fontana A, Lassmann H
Am J Pathol. 1999
PubMed ID: 10329594
Retroviral insertions in Evi12, a novel common virus integration site upstream of Tra1/Grp94, frequently coincide with insertions in the gene encoding the peripheral cannabinoid receptor Cnr2.
Valk PJ, Vankan Y, Joosten M, Jenkins NA, Copeland NG, Löwenberg B, Delwel R
J Virol. 1999
PubMed ID: 10196250
A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation.
Hill LL, Shreedhar VK, Kripke ML, Owen-Schaub LB
J Exp Med. 1999
PubMed ID: 10209045
Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis.
Sabelko-Downes KA, Cross AH, Russell JH
J Exp Med. 1999
PubMed ID: 10209037
CD95 ligand expression enhances growth of murine renal cell carcinoma in vivo.
Nishimatsu H, Takeuchi T, Ueki T, Kajiwara T, Moriyama N, Ishida T, Li B, Kakizoe T, Kitamura T
Cancer Immunol Immunother. 1999
PubMed ID: 10235489
Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.
Bartz SR, Emerman M
J Virol. 1999
PubMed ID: 9971775
Fas ligand (CD95 ligand) controls angiogenesis beneath the retina.
Kaplan HJ, Leibole MA, Tezel T, Ferguson TA
Nat Med. 1999
PubMed ID: 10086384
Potent inhibition of CD4/TCR-mediated T cell apoptosis by a CD4-binding glycoprotein secreted from breast tumor and seminal vesicle cells.
Gaubin M, Autiero M, Basmaciogullari S, Métivier D, Mis hal Z, Culerrier R, Oudin A, Guardiola J, Piatier-Tonneau D
J Immunol. 1999
PubMed ID: 10072505
Cytotoxicity is mandatory for CD8(+) T cell-mediated contact hypersensitivity.
Kehren J, Desvignes C, Krasteva M, Ducluzeau MT, Assossou O, Horand F, Hahne M, Kägi D, Kaiserlian D, Nicolas JF
J Exp Med. 1999
PubMed ID: 10049941
Timing and casting for actors of thymic negative selection.
Dautigny N, Le Campion A, Lucas B
J Immunol. 1999
PubMed ID: 9973382
Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway.
Zauli G, Gibellini D, Secchiero P, Dutartre H, Olive D, Capitani S, Collette Y
Blood. 1999
PubMed ID: 9920849
Role of Egr-2 in up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells.
Mittelstadt PR, Ashwell JD
J Biol Chem. 1999
PubMed ID: 9915863
Increased susceptibility of Fas ligand-deficient gld mice to Trypanosoma cruzi infection due to a Th2-biased host immune response.
Lopes MF, Nunes MP, Henriques-Pons A, Giese N, Morse HC, Davidson WF, Araújo-Jorge TC, DosReis GA
Eur J Immunol. 1999
PubMed ID: 9933089
Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death.
Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M
Mol Cell Biol. 1999
PubMed ID: 9858598
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.
Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, Godowski PJ, Wood WI, Gurney AL, Hillan KJ, Cohen RL, Goddard AD, Botstein D, Ashkenazi A
Nature. 1998
PubMed ID: 9872321
Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis.
Spielman J, Lee RK, Podack ER
J Immunol. 1998
PubMed ID: 9862744
Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas.
Fogler WE, Volker K, Watanabe M, Wigginton JM, Roessler P, Brunda MJ, Ortaldo JR, Wiltrout RH
J Immunol. 1998
PubMed ID: 9834083
Fas and Fas ligand interactions suppress melanoma lung metastasis.
Owen-Schaub LB, van Golen KL, Hill LL, Price JE
J Exp Med. 1998
PubMed ID: 9802983
Inducible nonlymphoid expression of Fas ligand is responsible for superantigen-induced peripheral deletion of T cells.
Bonfoco E, Stuart PM, Brunner T, Lin T, Griffith TS, Gao Y, Nakajima H, Henkart PA, Ferguson TA, Green DR
Immunity. 1998
PubMed ID: 9846492
Antitumor activity exhibited by Fas ligand (CD95L) overexpressed on lymphoid cells against Fas+ tumor cells.
Shimizu M, Takeda Y, Yagita H, Yoshimoto T, Matsuzawa A
Cancer Immunol Immunother. 1998
PubMed ID: 9829839
Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice.
Booker JK, Reap EA, Cohen PL
J Immunol. 1998
PubMed ID: 9794379
HIV/gp120 and PMA/ionomycin induced apoptosis but not activation induced cell death require PKC for Fas-L upregulation.
Accornero P, Radrizzani M, Carè A, Mattia G, Chiodoni C, Kurrle R, Colombo MP
FEBS Lett. 1998
PubMed ID: 9801169
Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma.
Matsui K, Fine A, Zhu B, Marshak-Rothstein A, Ju ST
J Immunol. 1998
PubMed ID: 9759866
Evidence for the involvement of Fas ligand and perforin in the induction of vascular leak syndrome.
Rafi AQ, Zeytun A, Bradley MJ, Sponenberg DP, Grayson RL, Nagarkatti M, Nagarkatti PS
J Immunol. 1998
PubMed ID: 9743374
Perforin-dependent neurologic injury in a viral model of multiple sclerosis.
Murray PD, McGavern DB, Lin X, Njenga MK, Leibowitz J, Pease LR, Rodriguez M
J Neurosci. 1998
PubMed ID: 9736651
Death receptors: signaling and modulation.
Ashkenazi A, Dixit VM
Science. 1998
PubMed ID: 9721089
Mice deficient in fas ligand (gld) or fas (lpr) show few alterations in granulopoiesis.
Fecho K, Bentley SA, Cohen PL
Cell Immunol. 1998
PubMed ID: 9743554
Amelioration of lymphoid hyperplasia and hypergammaglobulinemia in lupus-prone mice (gld) by Fas-ligand gene transfer.
Hong NM, Masuko-Hongo K, Sasakawa H, Kato T, Shirai T, Okumura K, Nishioka K, Kobata T
J Autoimmun. 1998
PubMed ID: 9776707
Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions.
Davidson WF, Giese T, Fredrickson TN
J Exp Med. 1998
PubMed ID: 9607923
Theiler's virus infection of genetically susceptible mice induces central nervous system-infiltrating CTLs with no apparent viral or major myelin antigenic specificity.
Lin X, Pease LR, Murray PD, Rodriguez M
J Immunol. 1998
PubMed ID: 9605173
Immunological and pathological consequences of mutations in both Fas and Fas ligand.
Weintraub JP, Godfrey V, Wolthusen PA, Cheek RL, Eisenberg RA, Cohen PL
Cell Immunol. 1998
PubMed ID: 9637760
Fas/Fas ligand signaling during gestational T cell development.
Fleck M, Zhou T, Tatsuta T, Yang P, Wang Z, Mountz JD
J Immunol. 1998
PubMed ID: 9558079
Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal.
Guy-Grand D, DiSanto JP, Henchoz P, Malassis-Séris M, Vassalli P
Eur J Immunol. 1998
PubMed ID: 9521083
The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity.
Conceição-Silva F, Hahne M, Schröter M, Louis J, Tschopp J
Eur J Immunol. 1998
PubMed ID: 9485203
HIV-1 gp120 accelerates Fas-mediated activation-induced human lamina propria T cell apoptosis.
Boirivant M, Viora M, Giordani L, Luzzati AL, Pronio AM, Montesani C, Pugliese O
J Clin Immunol. 1998
PubMed ID: 9475352
Downregulation of Fas ligand by shedding.
Tanaka M, Itai T, Adachi M, Nagata S
Nat Med. 1998
PubMed ID: 9427603
Separate domains of the human fas ligand dictate self-association and receptor binding.
Orlinick JR, Elkon KB, Chao MV
J Biol Chem. 1997
PubMed ID: 9405425
Allele-specific PCR analysis for detection of the gld Fas-ligand point mutation.
Hoek RM, Kortekaas MC, Sedgwick JD
J Immunol Methods. 1997
PubMed ID: 9502590
Gene transfer of Fas ligand induces tumor regression in vivo.
Arai H, Gordon D, Nabel EG, Nabel GJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9391118
Myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas- and Fas ligand-deficient lpr and gld mice.
Malipiero U, Frei K, Spanaus KS, Agresti C, Lassmann H, Hahne M, Tschopp J, Eugster HP, Fontana A
Eur J Immunol. 1997
PubMed ID: 9464800
Why do defects in the Fas-Fas ligand system cause autoimmunity?
Suda T, Nagata S
J Allergy Clin Immunol. 1997
PubMed ID: 9440553
CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.
Lesage S, Steff AM, Philippoussis F, Pagé M, Trop S, Mateo V, Hugo P
J Immunol. 1997
PubMed ID: 9366400
Impaired peripheral deletion of activated T cells in mice lacking the common cytokine receptor gamma-chain: defective Fas ligand expression in gamma-chain-deficient mice.
Nakajima H, Leonard WJ
J Immunol. 1997
PubMed ID: 9366397
Up-regulation of Fas and the costimulatory molecules B7-1 and B7-2 on peripheral lymphocytes in autoimmune B6/gld mice.
Weintraub JP, Eisenberg RA, Cohen PL
J Immunol. 1997
PubMed ID: 9379003
Apoptosis in the cornea: further characterization of Fas/Fas ligand system.
Mohan RR, Liang Q, Kim WJ, Helena MC, Baerveldt F, Wilson SE
Exp Eye Res. 1997
PubMed ID: 9464190
Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.
Waldner H, Sobel RA, Howard E, Kuchroo VK
J Immunol. 1997
PubMed ID: 9317104
Immunosensitization of prostate carcinoma cell lines for lymphocytes (CTL, TIL, LAK)-mediated apoptosis via the Fas-Fas-ligand pathway of cytotoxicity.
Frost P, Ng CP, Belldegrun A, Bonavida B
Cell Immunol. 1997
PubMed ID: 9316641
Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas.
Saras J, Engström U, Góñez LJ, Heldin CH
J Biol Chem. 1997
PubMed ID: 9261095
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation.
Graubert TA, DiPersio JF, Russell JH, Ley TJ
J Clin Invest. 1997
PubMed ID: 9259590
Characterization of Fas (Apo-1, CD95)-Fas ligand interaction.
Schneider P, Bodmer JL, Holler N, Mattmann C, Scuderi P, Terskikh A, Peitsch MC, Tschopp J
J Biol Chem. 1997
PubMed ID: 9228058
Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2.
Hashimoto F, Oyaizu N, Kalyanaraman VS, Pahwa S
Blood. 1997
PubMed ID: 9226175
Apoptosis induced by HIV-gp120 in a Th1 clone involves the generation of reactive oxygen intermediates downstream CD95 triggering.
Radrizzani M, Accornero P, Delia D, Kurrle R, Colombo MP
FEBS Lett. 1997
PubMed ID: 9247148
Daxx, a novel Fas-binding protein that activates JNK and apoptosis.
Yang X, Khosravi-Far R, Chang HY, Baltimore D
Cell. 1997
PubMed ID: 9215629
Rheumatic diseases in an MRL strain of mice with a deficit in the functional Fas ligand.
Ito MR, Terasaki S, Itoh J, Katoh H, Yonehara S, Nose M
Arthritis Rheum. 1997
PubMed ID: 9182916
Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions.
Reap EA, Roof K, Maynor K, Borrero M, Booker J, Cohen PL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9159145
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis.
Zhang X, Brunner T, Carter L, Dutton RW, Rogers P, Bradley L, Sato T, Reed JC, Green D, Swain SL
J Exp Med. 1997
PubMed ID: 9151709
Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.
Hunt JS, Vassmer D, Ferguson TA, Miller L
J Immunol. 1997
PubMed ID: 9126971
Identification of amino acid residues important for ligand binding to Fas.
Starling GC, Bajorath J, Emswiler J, Ledbetter JA, Aruffo A, Kiener PA
J Exp Med. 1997
PubMed ID: 9126929
Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis.
Cheng LE, Chan FK, Cado D, Winoto A
EMBO J. 1997
PubMed ID: 9155013
Polymorphism of murine Fas ligand that affects the biological activity.
Kayagaki N, Yamaguchi N, Nagao F, Matsuo S, Maeda H, Okumura K, Yagita H
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9108079
Enhancement of ectopic bone formation in mice with a deficit in Fas-mediated apoptosis.
Mori S, Nose M, Chiba M, Narita K, Kumagai M, Kosaka H, Teshima T
Pathol Int. 1997
PubMed ID: 9088029
CD95 ligand (FasL)-induced apoptosis is necessary for corneal allograft survival.
Stuart PM, Griffith TS, Usui N, Pepose J, Yu X, Ferguson TA
J Clin Invest. 1997
PubMed ID: 9022072
Differential susceptibility to HIV-GP120-sensitized apoptosis in CD4+ T-cell clones with different T-helper phenotypes: role of CD95/CD95L interactions.
Accornero P, Radrizzani M, Delia D, Gerosa F, Kurrle R, Colombo MP
Blood. 1997
PubMed ID: 9002959
Fas ligand-mediated depletion of CD4 and CD8 lymphocytes by monomeric HIV-1-gp120.
Uchiyama J, Kishi S, Yagita H, Matsuzaki S, Koga Y
Arch Virol. 1997
PubMed ID: 9672636
IL-1 beta convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms.
Smith DJ, McGuire MJ, Tocci MJ, Thiele DL
J Immunol. 1997
PubMed ID: 8977187
The role of the perforin and Fas pathways of cytotoxicity in skin graft rejection.
Selvaggi G, Ricordi C, Podack ER, Inverardi L
Transplantation. 1996
PubMed ID: 8990386
A major role for the Fas pathway in acute graft-versus-host disease.
Via CS, Nguyen P, Shustov A, Drappa J, Elkon KB
J Immunol. 1996
PubMed ID: 8955186
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
Hahne M, Rimoldi D, Schröter M, Romero P, Schreier M, French LE, Schneider P, Bornand T, Fontana A, Lienard D, Cerottini J, Tschopp J
Science. 1996
PubMed ID: 8910274
Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.
Okura T, Gong L, Kamitani T, Wada T, Okura I, Wei CF, Chang HM, Yeh ET
J Immunol. 1996
PubMed ID: 8906799
Fas-independent apoptosis of photoreceptor cells in C3H mice.
Nambu H, Yuge K, Shikata N, Tsubura A, Matsuzawa A
Exp Anim. 1996
PubMed ID: 8902493
Role of macrophages in the development of arteritis in MRL strains of mice with a deficit in Fas-mediated apoptosis.
Taniguchi Y, Ito MR, Mori S, Yonehara S, Nose M
Clin Exp Immunol. 1996
PubMed ID: 8870694
Contribution of Fas ligand to cardiac allograft rejection.
Seino K, Kayagaki N, Bashuda H, Okumura K, Yagita H
Int Immunol. 1996
PubMed ID: 8921411
Fas ligand mutation in a patient with systemic lupus erythematosus and lymphoproliferative disease.
Wu J, Wilson J, He J, Xiang L, Schur PH, Mountz JD
J Clin Invest. 1996
PubMed ID: 8787672
Fas system-mediated apoptosis suppresses lymphopoiesis.
Yasutomo K, Nagasawa H, Hisaeda H, Good RA, Kuroda Y, Himeno K
J Immunol. 1996
PubMed ID: 8757318
Vascular lesions in mice with a deficit in Fas-mediated apoptosis and their transfer.
Nose M, Ito MR, Ono M, Terasaki S, Miyazawa M, Mori S
Int J Cardiol. 1996
PubMed ID: 9119511
Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract.
Suzuki A, Matsuzawa A, Iguchi T
Oncogene. 1996
PubMed ID: 8700551
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death.
Boldin MP, Goncharov TM, Goltsev YV, Wallach D
Cell. 1996
PubMed ID: 8681376
The phosphotyrosine phosphatase inhibitor-phenylarsine oxide restores defective phosphoinositide hydrolysis response in anergic C3H-gld/gld lymphocytes.
Ling W, Tibbetts DJ, Crain RC, Lynes MA
Immunol Cell Biol. 1996
PubMed ID: 8799722
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice.
Baker MB, Altman NH, Podack ER, Levy RB
J Exp Med. 1996
PubMed ID: 8676085
Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide.
Brossart P, Bevan MJ
J Exp Med. 1996
PubMed ID: 8676065
Apoptosis of nur77/N10-transgenic thymocytes involves the Fas/Fas ligand pathway.
Weih F, Ryseck RP, Chen L, Bravo R
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8643610
Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.
Mieza MA, Itoh T, Cui JQ, Makino Y, Kawano T, Tsuchida K, Koike T, Shirai T, Yagita H, Matsuzawa A, Koseki H, Taniguchi M
J Immunol. 1996
PubMed ID: 8621946
Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.
Coerver KA, Woodruff TK, Finegold MJ, Mather J, Bradley A, Matzuk MM
Mol Endocrinol. 1996
PubMed ID: 8732684
Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo.
Ehl S, Hoffmann-Rohrer U, Nagata S, Hengartner H, Zinkernagel R
J Immunol. 1996
PubMed ID: 8786290
Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover.
French LE, Hahne M, Viard I, Radlgruber G, Zanone R, Becker K, Müller C, Tschopp J
J Cell Biol. 1996
PubMed ID: 8609166
Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice.
Tamura A, Katsumata M, Greene MI, Yui K
Cell Immunol. 1996
PubMed ID: 8640868
Activated B cells express functional Fas ligand.
Hahne M, Renno T, Schroeter M, Irmler M, French L, Bornard T, MacDonald HR, Tschopp J
Eur J Immunol. 1996
PubMed ID: 8605944
Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated function.
Cui H, Sherr DH, el-Khatib M, Matsui K, Panka DJ, Marshak-Rothstein A, Ju ST
Cell Immunol. 1996
PubMed ID: 8603437
Apoptosis in adult mouse testis induced by experimental cryptorchidism.
Ohta Y, Nishikawa A, Fukazawa Y, Urushitani H, Matsuzawa A, Nishina Y, Iguchi T
Acta Anat (Basel). 1996
PubMed ID: 9226038
Suppression and reversal of gld disease by parabiosis with normal mice.
Kakkanaiah VN, MacDonald GC, Cohen PL, Eisenberg RA
Clin Immunol Immunopathol. 1996
PubMed ID: 8599885
Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice.
Reap EA, Piecyk ML, Oliver A, Sobel ES, Waldschmidt T, Cohen PL, Eisenberg RA
Clin Immunol Immunopathol. 1996
PubMed ID: 8599880
Fas and FasL in the homeostatic regulation of immune responses.
Lynch DH, Ramsdell F, Alderson MR
Immunol Today. 1995
PubMed ID: 8579749
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor.
Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME
EMBO J. 1995
PubMed ID: 8521815
A role for CD95 ligand in preventing graft rejection.
Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC
Nature. 1995
PubMed ID: 7566174
Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain.
Hane M, Lowin B, Peitsch M, Becker K, Tschopp J
FEBS Lett. 1995
PubMed ID: 7589480
Apoptotic death of lymphocytes in murine acquired immunodeficiency syndrome: involvement of Fas-Fas ligand interaction.
Kanagawa O, Vaupel BA, Korsmeyer SJ, Russell JH
Eur J Immunol. 1995
PubMed ID: 7589105
Characterization of the non-functional Fas ligand of gld mice.
Hahne M, Peitsch MC, Irmler M, Schröter M, Lowin B, Rousseau M, Bron C, Renno T, French L, Tschopp J
Int Immunol. 1995
PubMed ID: 7495745
The accumulation of B220+ CD4- CD8- (DN) T cells in C3H-lpr/lpr mice is not accelerated by the stimulation of CD8+ T cells or B220+ DN T cells with staphylococcal enterotoxin B and occurs independently of V beta 8+ T cells.
Giese T, Davidson WF
Int Immunol. 1995
PubMed ID: 7495728
Age-dependent reduction of Bcl-2 expression in peripheral T cells of lpr and gld mutant mice.
Tamura A, Yui K
J Immunol. 1995
PubMed ID: 7602121
Comparative molecular modelling of the Fas-ligand and other members of the TNF family.
Peitsch MC, Tschopp J
Mol Immunol. 1995
PubMed ID: 7544870
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.
Westendorp MO, Frank R, Ochsenbauer C, Stricker K, Dhein J, Walczak H, Debatin KM, Krammer PH
Nature. 1995
PubMed ID: 7539892
A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain.
Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH, Wallach D
J Biol Chem. 1995
PubMed ID: 7536190
Development of grafted gld cells in athymic and euthymic recipients.
Rosenblatt N, Hartmann KU, Loor F
Immunology. 1995
PubMed ID: 7790030
Thymic microenvironmental abnormalities in MRL/MP-lpr/lpr, BXSB/MpJ Yaa and C3H HeJ-gld/gld mice.
Takeoka Y, Yoshida SH, Van de Water J, Boyd R, Suehiro S, Ansari AA, Gershwin ME
J Autoimmun. 1995
PubMed ID: 7612145
The Fas death factor.
Nagata S, Golstein P
Science. 1995
PubMed ID: 7533326
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.
Brunner T, Mogil RJ, LaFace D, Yoo NJ, Mahboubi A, Echeverri F, Martin SJ, Force WR, Lynch DH, Ware CF
Nature. 1995
PubMed ID: 7530336
Apoptosis abnormalities of splenic lymphocytes in autoimmune lpr and gld mice.
Reap EA, Leslie D, Abrahams M, Eisenberg RA, Cohen PL
J Immunol. 1995
PubMed ID: 7529292
Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.
Watanabe D, Suda T, Hashimoto H, Nagata S
EMBO J. 1995
PubMed ID: 7530197
A fas antigen receptor mutation allows development of toxic shock syndrome toxin-1-induced lethal shock in V beta 8.2 T-cell receptor transgenic mice.
Cullen CM, Bonventre PF, Heeg H, Bluethmann H, Mountz JD, Edwards CK
Pathobiology. 1995
PubMed ID: 8738468
Fas and Fas ligand: lpr and gld mutations.
Nagata S, Suda T
Immunol Today. 1995
PubMed ID: 7533498
Fas ligand mediates activation-induced cell death in human T lymphocytes.
Alderson MR, Tough TW, Davis-Smith T, Braddy S, Falk B, Schooley KA, Goodwin RG, Smith CA, Ramsdell F, Lynch DH
J Exp Med. 1995
PubMed ID: 7528780
Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.
Chu JL, Ramos P, Rosendorff A, Nikolić-Zugić J, Lacy E, Matsuzawa A, Elkon KB
J Exp Med. 1995
PubMed ID: 7528774
In vivo depletion of Thy-1-positive cells originating from normal bone marrow abrogates the suppression of gld disease in normal-gld mixed bone marrow chimeras.
MacDonald GC, Kakkanaiah VN, Sobel ES, Cohen PL, Eisenberg RA
J Immunol. 1995
PubMed ID: 7527820
Defective T cells from gld mice play a pivotal role in development of Thy-1.2+B220+ cells and autoimmunity.
Yasutomo K, Maeda K, Nagata S, Nagasawa H, Okada K, Good RA, Kuroda Y, Himeno K
J Immunol. 1994
PubMed ID: 7527451
Lymphotactin: a cytokine that represents a new class of chemokine.
Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ
Science. 1994
PubMed ID: 7973732
The Yaa gene-dependent B-cell deficiency worsens the generalized lymphadenopathy and autoimmunity of C57BL/6-gld male mice.
Rosenblatt N, Hartmann KU, Loor F
Immunology. 1994
PubMed ID: 7835973
Role of Fas ligand in apoptosis induced by hepatitis C virus infection.
Mita E, Hayashi N, Iio S, Takehara T, Hijioka T, Kasahara A, Fusamoto H, Kamada T
Biochem Biophys Res Commun. 1994
PubMed ID: 7980502
Human Fas ligand: gene structure, chromosomal location and species specificity.
Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S
Int Immunol. 1994
PubMed ID: 7826947
Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.
Baum PR, Gayle RB, Ramsdell F, Srinivasan S, Sorensen RA, Watson ML, Seldin MF, Baker E, Sutherland GR, Clifford KN
EMBO J. 1994
PubMed ID: 8076595
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways.
Lowin B, Hahne M, Mattmann C, Tschopp J
Nature. 1994
PubMed ID: 7520535
T cell specialization at environmental interfaces: T cells from the lung and the female genital tract of lpr and gld mice differ from their splenic and lymph node counterparts.
Ibraghimov AR, Lynch RG
Eur J Immunol. 1994
PubMed ID: 7519999
Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.
Matsuzawa A, Katagiri T, Ogata Y, Kominami R, Kimura M
Eur J Immunol. 1994
PubMed ID: 8026532
The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.
Rosenblatt N, Hartmann KU, Loor F
Cell Immunol. 1994
PubMed ID: 8025960
Molecular cloning of a murine N-acetylgalactosamine transferase cDNA that determines expression of the T lymphocyte-specific CT oligosaccharide differentiation antigen.
Smith PL, Lowe JB
J Biol Chem. 1994
PubMed ID: 7515051
Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.
Hanabuchi S, Koyanagi M, Kawasaki A, Shinohara N, Matsuzawa A, Nishimura Y, Kobayashi Y, Yonehara S, Yagita H, Okumura K
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7515183
The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster.
Lynch DH, Watson ML, Alderson MR, Baum PR, Miller RE, Tough T, Gibson M, Davis-Smith T, Smith CA, Hunter K
Immunity. 1994
PubMed ID: 7889405
gld/gld mice are unable to express a functional ligand for Fas.
Ramsdell F, Seaman MS, Miller RE, Tough TW, Alderson MR, Lynch DH
Eur J Immunol. 1994
PubMed ID: 7512035
Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway?
Vignaux F, Golstein P
Eur J Immunol. 1994
PubMed ID: 7512034
Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand.
Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S
Cell. 1994
PubMed ID: 7511063
Chronic treatment of C3H-lpr/lpr and C3H-gld/gld mice with anti-CD8 monoclonal antibody prevents the accumulation of double negative T cells but not autoantibody production.
Giese T, Davidson WF
J Immunol. 1994
PubMed ID: 8120404
Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.
Ettinger R, Wang JK, Bossu P, Papas K, Sidman CL, Abbas AK, Marshak-Rothstein A
J Immunol. 1994
PubMed ID: 8120369
The role of B cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice.
Eisenberg RA, Sobel ES, Reap EA, Halpern MD, Cohen PL
Semin Immunol. 1994
PubMed ID: 8167307
Gld and lpr mice: single gene mutant models for failed self tolerance.
Bhandoola A, Yui K, Siegel RM, Zerva L, Greene MI
Int Rev Immunol. 1994
PubMed ID: 7930847
Autoimmunity in mice bearing lprcg: a novel mutant gene.
Kimura M, Matsuzawa A
Int Rev Immunol. 1994
PubMed ID: 7930845
Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.
Suda T, Takahashi T, Golstein P, Nagata S
Cell. 1993
PubMed ID: 7505205
Dynamic associations of CD45 and Thy-1 on plasma membranes of C3H-gld/gld and C3H-lpr/lpr. I. Potential effects on proliferation and phosphatase activity.
Lynes MA, Tibbetts DJ, Swenson LM, Sidman CL
Cell Immunol. 1993
PubMed ID: 8104711
Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene.
Sobel ES, Kakkanaiah VN, Cohen PL, Eisenberg RA
Int Immunol. 1993
PubMed ID: 7505611
gld and lpr hematopoietic cell transfers: common and different serological features of the C57BL/6 chimeras.
Velin D, Goettelfinger P, Froidevaux S, Loor F
Cell Immunol. 1993
PubMed ID: 8098670
Evidence for early onset, polyclonal activation of T cell subsets in mice homozygous for lpr.
Giese T, Davidson WF
J Immunol. 1992
PubMed ID: 1383337
The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane.
Cohen PL, Eisenberg RA
Immunol Today. 1992
PubMed ID: 1282318
Murine models of autoimmunity: T-cell and B-cell defects.
Mountz JD, Edwards CK
Curr Opin Rheumatol. 1992
PubMed ID: 1419495
Adoptive transfer of the generalized lymphoproliferative disease (gld) syndrome in nude beige mice.
Froidevaux S, Rosenblatt N, Loor F
Immunology. 1992
PubMed ID: 1592442
Cell electrophoretic characterization of abnormally expanded lymphocytes in autoimmune lprcg, lpr, gld and Yaa mice, and of thymocyte subsets.
Shimizu M, Sekine K, Matsuzawa A, Iwaguchi T
Electrophoresis. 1992
PubMed ID: 1592043
Rheumatoid factors in mice bearing the lpr or gld mutation. Selective production of rheumatoid factor cryoglobulins in MRL/MPJ-lpr/lpr mice.
Shibata T, Berney T, Spertini F, Izui S
Clin Exp Immunol. 1992
PubMed ID: 1735182
Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.
Montecino-Rodriguez EM, Loor F
Immunology. 1991
PubMed ID: 1682243
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease.
Cohen PL, Eisenberg RA
Annu Rev Immunol. 1991
PubMed ID: 1910678
Different nature of the proliferation defects of GLD, LPR and MEV C57BL/6 mouse lymphoid cells.
Froidevaux S, Kuntz L, Velin D, Loor F
Autoimmunity. 1991
PubMed ID: 1756226
A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse.
Matsuzawa A, Moriyama T, Kaneko T, Tanaka M, Kimura M, Ikeda H, Katagiri T
J Exp Med. 1990
PubMed ID: 2406366
Analysis of granulomatous arteritis in MRL/Mp autoimmune disease mice bearing lymphoproliferative genes. The use of mouse genetics to dissociate the development of arteritis and glomerulonephritis.
Nose M, Nishimura M, Kyogoku M
Am J Pathol. 1989
PubMed ID: 2782373
Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.
Huppi K, Bhatia K, Siwarski D, Klinman D, Cherney B, Smulson M
Nucleic Acids Res. 1989
PubMed ID: 2498841
Abundant expression of type l K+ channels. A marker for lymphoproliferative diseases?
Grissmer S, Cahalan MD, Chandy KG
J Immunol. 1988
PubMed ID: 2456342
Molecular and functional properties of novel T cell subsets in C3H-gld/gld and nude mice. Implications for thymic and extrathymic maturation.
Yui K, Wadsworth S, Yellen A, Hashimoto Y, Kokai Y, Greene MI
Immunol Rev. 1988
PubMed ID: 3049314
Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group.
Seldin MF, Morse HC, Reeves JP, Scribner CL, LeBoeuf RC, Steinberg AD
J Exp Med. 1988
PubMed ID: 2894402
A molecular genetic approach to gld "autoimmune" disease.
Seldin MF, Morse HC, Steinberg AD
Curr Top Microbiol Immunol. 1988
PubMed ID: 3416634
Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice.
Davidson WF, Dumont FJ, Bedigian HG, Fowlkes BJ, Morse HC
J Immunol. 1986
PubMed ID: 3009614
Immunologic abnormalities of mice bearing the gld mutation suggest a common pathway for murine nonmalignant lymphoproliferative disorders with autoimmunity.
Davidson WF, Holmes KL, Roths JB, Morse HC
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3856256
A new mutation, gld, that produces lymphoproliferation and autoimmunity in C3H/HeJ mice.
Roths JB, Murphy ED, Eicher EM
J Exp Med. 1984
PubMed ID: 6693832

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	356	14103	25385
EnsEMBL Gene(s)	ENSG00000117560 LRG_58	ENSMUSG00000000817	ENSRNOG00000002978
Unigene	Hs.2007	Mm.3355	Rn.9725
Homologene	FASLG	Fasl	Faslg
OMIM	134638	N/A	N/A
GeneCards	FASLG	N/A	N/A
Beta Cell Genomics	DT.100746121 DT.309278	DT.101360960 DT.40147693 DT.91446661 DT.91446662	N/A
Reactome	P48023	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	356	14103	25385

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Interactor	Interactor	Sources	Classification	Pubmed IDs
FASLG	PDCD6	HPRD	empirical	11606059
FASLG	SORBS3	IntAct	empirical	19807924
FASLG	GRAP	HPRD, BioGRID	empirical	11741599
FASLG	PACSIN2	HPRD, MINT, BioGRID	empirical	12023017 16318909
FASLG	SNX18	MINT, IntAct	empirical	17761170 19807924
FASLG	CRK	IntAct	empirical	19807924
FASLG	RIMBP3C	IntAct	empirical	19807924
FASLG	SH3RF2	IntAct	empirical	19807924
FASLG	DAXX	HPRD	empirical	9215629
FASLG	AP2B1	MINT	empirical	17761170
FASLG	DLG2	IntAct	empirical	19807924
FASLG	DMD	HPRD	empirical	11741599
FASLG	FGR	BioGRID	empirical	17164290
FASLG	FNBP1	HPRD, MINT, BioGRID	empirical	12023017 16318909
FASLG	DNMBP	IntAct	empirical	19807924
FASLG	FN1	HPRD, BioGRID	empirical	11276204
FASLG	SRGAP2	MINT, IntAct	empirical	16318909 19807924
FASLG	FYB	IntAct	empirical	19807924
FASLG	FYN	HPRD, IntAct	empirical	7589480 19807924
FASLG	SNX33	IntAct	empirical	19807924
FASLG	OSTF1	IntAct	empirical	19807924
FASLG	TJP3	IntAct	empirical	19807924
FASLG	SH3PXD2B	IntAct	empirical	19807924
FASLG	GRB2	HPRD, BioGRID	empirical	11741599 12023017 12220636
FASLG	PACSIN3	MINT	empirical	16318909
FASLG	PACSIN1	MINT	empirical	16318909
FASLG	HCK	IntAct	empirical	19807924
FASLG	APBB1	HPRD	empirical	11741599
FASLG	MACC1	IntAct	empirical	19807924
FASLG	FAS	HPRD, IntAct, BioGRID, Reactome	empirical	9228058 9126929 12887920 15659383 12753742 7530336
FASLG	ITK	IntAct	empirical	19807924
FASLG	RHOA	BioGRID	empirical	15659383
FASLG	ARHGAP4	MINT	empirical	16318909
FASLG	LCK	HPRD, BioGRID	empirical	11741599
FASLG	ARHGDIA	BioGRID	empirical	15659383
FASLG	LYN	IntAct, BioGRID	empirical	19807924 17164290
FASLG	MLL	HPRD	empirical	12023017
FASLG	MMP7	HPRD, BioGRID	empirical	12464266
FASLG	MSN	BioGRID	empirical	15659383
FASLG	NCK1	HPRD, IntAct, BioGRID	empirical	11741599 19807924
FASLG	ITSN2	IntAct	empirical	19807924
FASLG	MYO15A	IntAct	empirical	19807924
FASLG	SNX9	IntAct	empirical	19807924
FASLG	NCKIPSD	IntAct	empirical	19807924
FASLG	PIK3R1	HPRD, IntAct	empirical	11741599 19807924
FASLG	PIN1	HPRD	empirical	11741599
FASLG	PRPF40A	HPRD	empirical	11741599
FASLG	BAIAP2L1	IntAct	empirical	19807924
FASLG	MAPK8	BioGRID	empirical	15659383
FASLG	SRGAP1	IntAct	empirical	19807924
FASLG	PTPN12	MINT	empirical	16204241
FASLG	PTPN13	HPRD, BioGRID	empirical	9261095 16498403
FASLG	MPP4	IntAct	empirical	19807924
FASLG	BID	BioGRID	empirical	15659383
FASLG	SAMSN1	IntAct	empirical	19807924
FASLG	ARHGAP9	IntAct	empirical	19807924
FASLG	SH3GL3	IntAct	empirical	19807924
FASLG	NCF1	HPRD, IntAct	empirical	11741599 19807924
FASLG	SPTA1	IntAct	empirical	19807924
FASLG	SRC	HPRD, IntAct	empirical	11741599 19807924
FASLG	BTK	IntAct	empirical	19807924
FASLG	TEC	IntAct	empirical	19807924
FASLG	TNFRSF1A	BioGRID	empirical	15659383 12753742
FASLG	UBC	BioGRID	empirical	17164290
FASLG	SUMO1	HPRD	empirical	8906799
FASLG	EZR	HPRD, BioGRID	empirical	11013215 15659383
FASLG	YES1	IntAct	empirical	19807924
FASLG	CACNB3	IntAct	empirical	19807924
FASLG	CACNB4	IntAct	empirical	19807924
FASLG	EPS8L3	IntAct	empirical	19807924
FASLG	MIA	IntAct	empirical	19807924
FASLG	CASP8	MINT, IntAct, BioGRID	empirical	16498403 12198154 12887920 15659383 12753742
FASLG	CASP10	MINT, IntAct, BioGRID	empirical	16498403 12198154 15659383
FASLG	NCK2	IntAct	empirical	19807924
FASLG	TNFRSF6B	BioGRID	empirical	10318773 11994433 9872321
FASLG	FADD	HPRD, MINT, IntAct, BioGRID	empirical	12887920 16498403 15659383 12753742
FASLG	TNFRSF10B	BioGRID	empirical	15659383
FASLG	SKAP2	IntAct	empirical	19807924
FASLG	KALRN	IntAct	empirical	19807924
FASLG	PSTPIP1	HPRD, MINT, IntAct	empirical	16204241 16318909 19807924
FASLG	TRIP10	MINT	empirical	16318909
FASLG	GRAP2	HPRD, BioGRID	empirical	11741599
FASLG	SH3PXD2A	IntAct	empirical	19807924
FASLG	DOCK4	IntAct	empirical	19807924
FASLG	SRGAP3	IntAct	empirical	19807924