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IL2RA

Gene Description:   interleukin 2 receptor, alpha; interleukin 2 receptor, alpha chain Synonyms:   IL2R, IDDM10, CD25, IL2RAC, Il2ra, Il2r, TCGFR, Ly-43, IL2RA, MGC130561 Orthologs:   Human IL2RA (protein-coding), Mouse Il2ra (protein-coding), Rat Il2ra (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, KEGG Mouse-Rat: HomoloGene, MGD, RGD, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
10p15.1	Human	chr10:6029726..6197536	0.17	19	rs12722495 rs11594656 rs12251307

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 10p15.1 Orthologous Region	Rat	chr17:78043929..78203116	0.16	2
Human 10p15.1 Orthologous Region	Mouse	chr2:11461896..11617675	0.16	3

(Human) GRCh37 - chr10:6052652..6104333 (51.68 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr2:11564419..11614821 (50.40 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr17:78050491..78097802 (47.31 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for IL2RA: The IL2RA interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs IL2RA   ICAM1   HPRD  empirical  1976256  IL2RA   IL2   HPRD, Reactome  empirical  1993646  16477002  1526987  8700888  IL2RA   IL2RA   HPRD  empirical  11886175  IL2RA   IL2RB   HPRD, Reactome  empirical  11886175  8700888  IL2RA   JAK1   Reactome  predicted  8700888  IL2RA   NFKB1   HPRD  empirical  2497520  IL2RA   STAT3   HPRD  empirical  10602027  IL2RA   STAT5B   HPRD  empirical  10602027  IL2RA   CD4   HPRD  empirical  7539755

View all

KEGG Network: 5   Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Endocytosis Human - 4144 Mouse - 4144 Rat - 4144 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Measles Human - 5162 Mouse - 5162 Rat - 5162

Biocarta: 4   IL 2 signaling pathway Human Mouse IL-2 Receptor Beta Chain in T cell Activation Human Mouse Role of Tob in T-cell activation Human Mouse Th1/Th2 Differentiation Human Mouse

Reactome: 3   Interleukin receptor SHC signaling REACT_23891 Interleukin-3, 5 and GM-CSF signaling REACT_23837 Signaling by Interleukins REACT_22232

NCI-Nature Pathway Interaction Database: 9   Arf6 trafficking events Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL2-mediated signaling events IL2 signaling events mediated by PI3K Downstream signaling in naïve CD8+ T cells IL2 signaling events mediated by STAT5 Calcium signaling in the CD4+ TCR pathway IL12 signaling mediated by STAT4 IL12-mediated signaling events

Gene Ontology: 20   Inflammatory response to antigenic stimulus GO:0002437 Receptor activity GO:0004872 Interleukin-2 receptor activity GO:0004911 Plasma membrane GO:0005886 Apoptosis GO:0006915 Activation-induced cell death of T cells GO:0006924 Immune response GO:0006955 Cell surface receptor linked signaling pathway GO:0007166 Drug binding GO:0008144 Cell proliferation GO:0008283 External side of plasma membrane GO:0009897 Integral to membrane GO:0016021 Positive regulation of activated T cell proliferation GO:0042104 Negative regulation of T cell proliferation GO:0042130 Positive regulation of apoptosis GO:0043065 Positive regulation of T cell differentiation GO:0045582 Regulation of T cell homeostatic proliferation GO:0046013 Negative regulation of defense response to virus GO:0050687 Negative regulation of inflammatory response GO:0050728 Negative regulation of immune response GO:0050777

	KEGG Network: 5 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Endocytosis Human - 4144 Mouse - 4144 Rat - 4144 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Measles Human - 5162 Mouse - 5162 Rat - 5162
	Biocarta: 4 IL 2 signaling pathway Human Mouse IL-2 Receptor Beta Chain in T cell Activation Human Mouse Role of Tob in T-cell activation Human Mouse Th1/Th2 Differentiation Human Mouse
	Reactome: 3 Interleukin receptor SHC signaling REACT_23891 Interleukin-3, 5 and GM-CSF signaling REACT_23837 Signaling by Interleukins REACT_22232
	NCI-Nature Pathway Interaction Database: 9 Arf6 trafficking events Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL2-mediated signaling events IL2 signaling events mediated by PI3K Downstream signaling in naïve CD8+ T cells IL2 signaling events mediated by STAT5 Calcium signaling in the CD4+ TCR pathway IL12 signaling mediated by STAT4 IL12-mediated signaling events
	Gene Ontology: 20 Inflammatory response to antigenic stimulus GO:0002437 Receptor activity GO:0004872 Interleukin-2 receptor activity GO:0004911 Plasma membrane GO:0005886 Apoptosis GO:0006915 Activation-induced cell death of T cells GO:0006924 Immune response GO:0006955 Cell surface receptor linked signaling pathway GO:0007166 Drug binding GO:0008144 Cell proliferation GO:0008283 External side of plasma membrane GO:0009897 Integral to membrane GO:0016021 Positive regulation of activated T cell proliferation GO:0042104 Negative regulation of T cell proliferation GO:0042130 Positive regulation of apoptosis GO:0043065 Positive regulation of T cell differentiation GO:0045582 Regulation of T cell homeostatic proliferation GO:0046013 Negative regulation of defense response to virus GO:0050687 Negative regulation of inflammatory response GO:0050728 Negative regulation of immune response GO:0050777

Type 1 Diabetes Publications: 36

• Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population.
  Aminkeng F, Weets I, Van Autreve JE, Koeleman BP, Quartier E, Van Schravendijk C, Gorus FK, Van der Auwera BJ, Belgian Diabetes Registry
  Hum Immunol. 2010
  PubMed ID: 20849903
   
  
• Association of the protein tyrosine phosphatase nonreceptor 22 haplotypes with autoimmune thyroid disease in the Japanese population.
  Ban Y, Tozaki T, Taniyama M, Nakano Y, Ban Y, Ban Y, Hirano T
  Thyroid. 2010
  PubMed ID: 20615141
   
  
• In silico replication of the genome-wide association results of the Type 1 Diabetes Genetics Consortium.
  Qu HQ, Bradfield JP, Li Q, Kim C, Frackelton E, Grant SF, Hakonarson H, Polychronakos C
  Hum Mol Genet. 2010
  PubMed ID: 20378605
   
  
• Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
  Pierce BL, Ahsan H
  Hum Hered. 2010
  PubMed ID: 20203524
   
  
• Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects.
  Klinker MW, Schiller JJ, Magnuson VL, Wang T, Basken J, Veth K, Pearce KI, Kinnunen L, Harjutsalo V, Wang X, Tuomilehto J, Sarti C, Ghosh S
  Immunogenetics. 2009
  PubMed ID: 20033399
   
  
• The type I diabetes association of the IL2RA locus.
  Qu HQ, Bradfield JP, Bélisle A, Grant SF, Hakonarson H, Polychronakos C, Type I Diabetes Genetics Consortium
  Genes Immun. 2009
  PubMed ID: 19956099
   
  
• Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms.
  Liu Q, Sundar K, Mishra PK, Mousavi G, Liu Z, Gaydo A, Alem F, Lagunoff D, Bleich D, Gause WC
  Infect Immun. 2009
  PubMed ID: 19752032
   
  
• Genetic heterogeneity in latent autoimmune diabetes (LADA) is linked to a varying degree of autoimmune activity. Results from the Nord-Trondelag Health Study.
  Pettersen E, Skorpen F, Kvaløy K, Midthjell K, Grill V
  Diabetes. 2009
  PubMed ID: 19833889
   
  
• A cis-acting regulatory variant in the IL2RA locus.
  Qu HQ, Verlaan DJ, Ge B, Lu Y, Lam KC, Grabs R, Harmsen E, Hudson TJ, Hakonarson H, Pastinen T, Polychronakos C
  J Immunol. 2009
  PubMed ID: 19794070
   
  
• Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
  Dendrou CA, Plagnol V, Fung E, Yang JH, Downes K, Cooper JD, Nutland S, Coleman G, Himsworth M, Hardy M, Burren O, Healy B, Walker NM, Koch K, Ouwehand WH, Bradley JR, Wareham NJ, Todd JA, Wicker LS
  Nat Genet. 2009
  PubMed ID: 19701192
   
  
• Novel Association of the Interleukin 2-Interleukin 21 Region With Inflammatory Bowel Disease.
  Márquez A, Orozco G, Martínez A, Palomino-Morales R, Fernández-Arquero M, Mendoza JL, Taxonera C, Díaz-Rubio M, Gómez-García M, Nieto A, López-Nevot MA, de la Concha EG, Martín J, Urcelay E
  Am J Gastroenterol. 2009
  PubMed ID: 19471255
   
  
• IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity.
  Wang J, Wicker LS, Santamaria P
  Semin Immunol. 2009
  PubMed ID: 19447046
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes.
  Nejentsev S, Walker N, Riches D, Egholm M, Todd JA
  Science. 2009
  PubMed ID: 19264985
   
  
• Genetic Association between the Interleukin-2 Receptor-{alpha} Gene and Mode of Onset of Type 1 Diabetes in the Japanese Population.
  Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, Tanaka S, Kanazawa Y, Eguchi K, the Japanese Study Group on Type 1 Diabetes Genetics
  J Clin Endocrinol Metab. 2009
  PubMed ID: 19106270
   
  
• Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.
  Maier LM, Anderson DE, Severson CA, Baecher-Allan C, Healy B, Liu DV, Wittrup KD, De Jager PL, Hafler DA
  J Immunol. 2009
  PubMed ID: 19155502
   
  
• Upregulating CD4+CD25+FOXP3+ regulatory T cells in pancreatic lymph nodes in diabetic NOD mice by adjuvant immunotherapy.
  Tian B, Hao J, Zhang Y, Tian L, Yi H, O'Brien TD, Sutherland DE, Hering BJ, Guo Z
  Transplantation. 2009
  PubMed ID: 19155973
   
  
• Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.
  Chen G, Han G, Feng J, Wang J, Wang R, Xu R, Shen B, Qian J, Li Y
  PLoS One. 2009
  PubMed ID: 19759824
   
  
• Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis.
  Carr EJ, Clatworthy MR, Lowe CE, Todd JA, Wong A, Vyse TJ, Kamesh L, Watts RA, Lyons PA, Smith KG
  BMC Med Genet. 2009
  PubMed ID: 19265545
   
  
• IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).
  Alcina A, Fedetz M, Ndagire D, Fernández O, Leyva L, Guerrero M, Abad-Grau MM, Arnal C, Delgado C, Lucas M, Izquierdo G, Matesanz F
  PLoS ONE. 2009
  PubMed ID: 19125193
   
  
• IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.
  Maier LM, Lowe CE, Cooper J, Downes K, Anderson DE, Severson C, Clark PM, Healy B, Walker N, Aubin C, Oksenberg JR, Hauser SL, Compston A, Sawcer S, International Multiple Sclerosis Genetics Consortium, De Jager PL, Wicker LS, Todd JA, Hafler DA
  PLoS Genet. 2009
  PubMed ID: 19119414
   
  
• Association of the IL2RA/CD25 gene with juvenile idiopathic arthritis.
  Hinks A, Ke X, Barton A, Eyre S, Bowes J, Worthington J, Thompson SD, Langefeld CD, Glass DN, Thomson W, UK Rheumatoid Arthritis Genetics Consortium, British Society of Paediatric and Adolescent Rheumatology Study Group
  Arthritis Rheum. 2009
  PubMed ID: 19116909
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• Prevention of diabetes: effect of mycophenolate mofetil and anti-CD25 on onset of diabetes in the DRBB rat.
  Ugrasbul F, Moore WV, Tong PY, Kover KL
  Pediatr Diabetes. 2008
  PubMed ID: 18503494
   
  
• The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice.
  Dendrou CA, Wicker LS
  J Clin Immunol. 2008
  PubMed ID: 18780166
   
  
• Characterization of CD4+CD25+ natural regulatory T cells in the inflammatory infiltrate of human chronic periodontitis.
  Cardoso CR, Garlet GP, Moreira AP, Júnior WM, Rossi MA, Silva JS
  J Leukoc Biol. 2008
  PubMed ID: 18451325
   
  
• Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial.
  Butty V, Campbell C, Mathis D, Benoist C, the Diabetes Prevention Trial-Type 1 Study Group
  Diabetes. 2008
  PubMed ID: 18556337
   
  
• Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
  Lowe CE, Cooper JD, Brusko T, Walker NM, Smyth DJ, Bailey R, Bourget K, Plagnol V, Field S, Atkinson M, Clayton DG, Wicker LS, Todd JA
  Nat Genet. 2007
  PubMed ID: 17676041
   
  
• Toward further mapping of the association between the IL2RA locus and type 1 diabetes.
  Qu HQ, Montpetit A, Ge B, Hudson TJ, Polychronakos C
  Diabetes. 2007
  PubMed ID: 17395754
   
  
• Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs.
  Brand OJ, Lowe CE, Heward JM, Franklyn JA, Cooper JD, Todd JA, Gough SC
  Clin Endocrinol (Oxf). 2007
  PubMed ID: 17371467
   
  
• Deficiency in NOD antigen-presenting cell function may be responsible for suboptimal CD4+CD25+ T-cell-mediated regulation and type 1 diabetes development in NOD mice.
  Alard P, Manirarora JN, Parnell SA, Hudkins JL, Clark SL, Kosiewicz MM
  Diabetes. 2006
  PubMed ID: 16804081
   
  
• Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
  Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP
  J Allergy Clin Immunol. 2006
  PubMed ID: 16750991
   
  
• Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire.
  Fisson S, Djelti F, Trenado A, Billiard F, Liblau R, Klatzmann D, Cohen JL, Salomon BL
  Eur J Immunol. 2006
  PubMed ID: 16525991
   
  
• Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes.
  Endl J, Rosinger S, Schwarz B, Friedrich SO, Rothe G, Karges W, Schlosser M, Eiermann T, Schendel DJ, Boehm BO
  Diabetes. 2006
  PubMed ID: 16380476
   
  
• Where CD4+CD25+ T reg cells impinge on autoimmune diabetes.
  Chen Z, Herman AE, Matos M, Mathis D, Benoist C
  J Exp Med. 2005
  PubMed ID: 16301745
   
  
• Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
  Vella A, Cooper JD, Lowe CE, Walker N, Nutland S, Widmer B, Jones R, Ring SM, McArdle W, Pembrey ME, Strachan DP, Dunger DB, Twells RC, Clayton DG, Todd JA
  Am J Hum Genet. 2005
  PubMed ID: 15776395
   
  

Publications: 484

• Presence of activated airway T lymphocytes in human puumala hantavirus disease.
  Rasmuson J, Pourazar J, Linderholm M, Sandström T, Blomberg A, Ahlm C
  Chest. 2011
  PubMed ID: 21436245
   
  
• Depletion of CD25⁺ T cells from hematopoietic stem cell grafts increases posttransplantation vaccine-induced immunity to neuroblastoma.
  Jing W, Yan X, Hallett WH, Gershan JA, Johnson BD
  Blood. 2011
  PubMed ID: 21521781
   
  
• CDK6 kinase activity is required for thymocyte development.
  Hu MG, Deshpande A, Schlichting N, Hinds EA, Mao C, Dose M, Hu GF, Van Etten RA, Gounari F, Hinds PW
  Blood. 2011
  PubMed ID: 21508411
   
  
• CD4+CD25+Foxp3+ regulatory T cells are dispensable for controlling CD8+ T cell-mediated lung inflammation.
  Tosiek MJ, Gruber AD, Bader SR, Mauel S, Hoymann HG, Prettin S, Tschernig T, Buer J, Gereke M, Bruder D
  J Immunol. 2011
  PubMed ID: 21518973
   
  
• High mobility group box-1 protein regulate immunosuppression of regulatory T cells through toll-like receptor 4.
  Zhu XM, Yao YM, Liang HP, Xu CT, Dong N, Yu Y, Sheng ZY
  Cytokine. 2011
  PubMed ID: 21419643
   
  
• Alleviating allergic airway diseases by means of short-term administration of IL-2 and dexamethasone.
  Ma J, Yang A, Qin W, Shi Y, Zhao B, Jin Y, Xie Y
  J Allergy Clin Immunol. 2011
  PubMed ID: 21377197
   
  
• Human colonic myofibroblasts promote expansion of CD4+ CD25high Foxp3+ regulatory T cells.
  Pinchuk IV, Beswick EJ, Saada JI, Boya G, Schmitt D, Raju GS, Brenmoehl J, Rogler G, Reyes VE, Powell DW
  Gastroenterology. 2011
  PubMed ID: 21376048
   
  
• Differential expression of monocyte/macrophage- selective markers in human idiopathic pulmonary fibrosis.
  Desai B, Mattson J, Paintal H, Nathan M, Shen F, Beaumont M, Malinao MC, Li Y, Canfield J, Basham B, de Waal Malefyt R, McClanahan T, Krishna G, Fick R
  Exp Lung Res. 2011
  PubMed ID: 21309737
   
  
• Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995.
  Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M
  J Immunol. 2011
  PubMed ID: 21422251
   
  
• IL-22 is produced by γC-independent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality.
  Dumoutier L, de Heusch M, Orabona C, Satoh-Takayama N, Eberl G, Sirard JC, Di Santo JP, Renauld JC
  Eur J Immunol. 2011
  PubMed ID: 21400499
   
  
• Induction of T regulatory cells by cytotoxic T-lymphocyte antigen-2α on corneal endothelial cells.
  Sugita S, Yamada Y, Horie S, Nakamura O, Ishidoh K, Yamamoto Y, Yamagami S, Mochizuki M
  Invest Ophthalmol Vis Sci. 2011
  PubMed ID: 21245393
   
  
• CD2 costimulation reveals defective activity by human CD4+CD25(hi) regulatory cells in patients with multiple sclerosis.
  Baecher-Allan CM, Costantino CM, Cvetanovich GL, Ashley CW, Beriou G, Dominguez-Villar M, Hafler DA
  J Immunol. 2011
  PubMed ID: 21300823
   
  
• Human cord blood CD4+CD25hi regulatory T cells suppress prenatally acquired T cell responses to Plasmodium falciparum antigens.
  Mackroth MS, Malhotra I, Mungai P, Koech D, Muchiri E, King CL
  J Immunol. 2011
  PubMed ID: 21278348
   
  
• Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD.
  Roos-Engstrand E, Pourazar J, Behndig AF, Bucht A, Blomberg A
  Respir Res. 2011
  PubMed ID: 21651772
   
  
• Effect of age on surface molecules and cytokine expression in human dendritic cells.
  Ciaramella A, Spalletta G, Bizzoni F, Salani F, Caltagirone C, Bossù P
  Cell Immunol. 2011
  PubMed ID: 21571262
   
  
• Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy.
  Milani P, Marilley M, Sanchez-Sevilla A, Imbert J, Vaillant C, Argoul F, Egly JM, Rocca-Serra J, Arneodo A
  PLoS One. 2011
  PubMed ID: 21533205
   
  
• Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.
  Wang Q, Chow J, Hong J, Smith AF, Moreno C, Seaby P, Vrana P, Miri K, Tak J, Chung ED, Mastromonaco G, Caniggia I, Varmuza S
  BMC Genomics. 2011
  PubMed ID: 21510876
   
  
• Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients.
  Fritzsching B, Haas J, König F, Kunz P, Fritzsching E, Pöschl J, Krammer PH, Brück W, Suri-Payer E, Wildemann B
  PLoS One. 2011
  PubMed ID: 21437244
   
  
• Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
  Melum E, Franke A, Schramm C, Weismüller TJ, Gotthardt DN, Offner FA, Juran BD, Laerdahl JK, Labi V, Björnsson E, Weersma RK, Henckaerts L, Teufel A, Rust C, Ellinghaus E, Balschun T, Boberg KM, Ellinghaus D, Bergquist A, Sauer P, Ryu E, Hov JR, Wedemeyer J, Lindkvist B, Wittig M, Porte RJ, Holm K, Gieger C, Wichmann HE, Stokkers P, Ponsioen CY, Runz H, Stiehl A, Wijmenga C, Sterneck M, Vermeire S, Beuers U, Villunger A, Schrumpf E, Lazaridis KN, Manns MP, Schreiber S, Karlsen TH
  Nat Genet. 2011
  PubMed ID: 21151127
   
  
• The vitamin D analog, TX527, promotes a human CD4+CD25highCD127low regulatory T cell profile and induces a migratory signature specific for homing to sites of inflammation.
  Baeke F, Korf H, Overbergh L, Verstuyf A, Thorrez L, Van Lommel L, Waer M, Schuit F, Gysemans C, Mathieu C
  J Immunol. 2011
  PubMed ID: 21131424
   
  
• Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells.
  Preston JA, Thorburn AN, Starkey MR, Beckett EL, Horvat JC, Wade MA, O'Sullivan BJ, Thomas R, Beagley KW, Gibson PG, Foster PS, Hansbro PM
  Eur Respir J. 2011
  PubMed ID: 20525707
   
  
• IL-21 induces death of marginal zone B cells during chronic inflammation.
  Tortola L, Yadava K, Bachmann MF, Müller C, Kisielow J, Kopf M
  Blood. 2010
  PubMed ID: 20826721
   
  
• Clinical relevance of elevated levels of serum soluble interleukin-2 receptor alpha (sIL-2Rα) in patients with non-Hodgkin's lymphoma.
  Jo SA, Hwang SH, Chang CL, Kim SY, Shin HJ, Chung JS, Sol MY, Lee EY
  Korean J Lab Med. 2010
  PubMed ID: 21157146
   
  
• Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
  Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M
  Nat Genet. 2010
  PubMed ID: 21102463
   
  
• CD4+CD25+Foxp3+ regulatory T cells protect the proinflammatory activation of human umbilical vein endothelial cells.
  He S, Li M, Ma X, Lin J, Li D
  Arterioscler Thromb Vasc Biol. 2010
  PubMed ID: 20930173
   
  
• CD4+CD25+ regulatory T cells attenuate cisplatin-induced nephrotoxicity in mice.
  Lee H, Nho D, Chung HS, Lee H, Shin MK, Kim SH, Bae H
  Kidney Int. 2010
  PubMed ID: 20463654
   
  
• Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
  Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
  Haematologica. 2010
  PubMed ID: 21048031
   
  
• Astragalus membranaceus injection delayed allograft survival related with CD4+ CD25+ regulatory T cells.
  Qu LL, Su YL, Li CX, Hou GH
  Transplant Proc. 2010
  PubMed ID: 21094858
   
  
• Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.
  Alachkar N, Ugarte R, Huang E, Womer KL, Montgomery R, Kraus E, Rabb H
  Transplant Proc. 2010
  PubMed ID: 21094786
   
  
• Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.
  Wiesel M, Joller N, Ehlert AK, Crouse J, Spörri R, Bachmann MF, Oxenius A
  J Immunol. 2010
  PubMed ID: 20881183
   
  
• Influence of IL2RA rs2104286 polymorphism in the risk of biopsy-proven giant cell arteritis.
  Rodríguez-Rodríguez L, Castañeda S, Vázquez-Rodríguez TR, Morado IC, Marí-Alfonso B, Gómez-Vaquero C, Miranda-Filloy JA, Ortego-Centeno N, Narvaez J, Blanco R, Fernández-Gutiérrez B, Martín J, González-Gay MA
  J Rheumatol. 2010
  PubMed ID: 20810507
   
  
• CD4+ CD25+ but not CD4+ Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis.
  Wang D, Zhang H, Liang J, Gu Z, Zhou Q, Fan X, Hou Y, Sun L
  Cell Mol Immunol. 2010
  PubMed ID: 20729906
   
  
• T regulatory cells control T-cell proliferation partly by the release of soluble CD25 in patients with B-cell malignancies.
  Lindqvist CA, Christiansson LH, Simonsson B, Enblad G, Olsson-Strömberg U, Loskog AS
  Immunology. 2010
  PubMed ID: 20518821
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• B cell abnormalities in Wegener's granulomatosis and microscopic polyangiitis: role of CD25+-expressing B cells.
  Eriksson P, Sandell C, Backteman K, Ernerudh J
  J Rheumatol. 2010
  PubMed ID: 20716663
   
  
• A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
  Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20673868
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation.
  Ladd M, Sharma A, Huang Q, Wang AY, Xu L, Genowati I, Levings MK, Lavoie PM
  Immunology. 2010
  PubMed ID: 20545784
   
  
• The genetics of multiple sclerosis: an update 2010.
  Hoffjan S, Akkad DA
  Mol Cell Probes. 2010
  PubMed ID: 20450971
   
  
• The associations of circulating CD4+CD25high regulatory T cells and TGF-β with disease activity and clinical course in patients with adult-onset Still's disease.
  Chen DY, Chen YM, Chen HH, Hsieh CW, Lin CC, Lan JL
  Connect Tissue Res. 2010
  PubMed ID: 20388015
   
  
• The impact of IL2ra induction therapy in kidney transplantation using tacrolimus- and mycophenolate-based immunosuppression.
  Gralla J, Wiseman AC
  Transplantation. 2010
  PubMed ID: 20595929
   
  
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20716621
   
  
• Transforming growth factor beta and CD25 are important for controlling systemic dissemination following Yersinia enterocolitica infection of the gut.
  Zhong Y, Cantwell A, Dube PH
  Infect Immun. 2010
  PubMed ID: 20584975
   
  
• Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis.
  Ammirati E, Cianflone D, Banfi M, Vecchio V, Palini A, De Metrio M, Marenzi G, Panciroli C, Tumminello G, Anzuini A, Palloshi A, Grigore L, Garlaschelli K, Tramontana S, Tavano D, Airoldi F, Manfredi AA, Catapano AL, Norata GD
  Arterioscler Thromb Vasc Biol. 2010
  PubMed ID: 20539016
   
  
• Deficient CD4+CD25+ T regulatory cell function in patients with abdominal aortic aneurysms.
  Yin M, Zhang J, Wang Y, Wang S, Böckler D, Duan Z, Xin S
  Arterioscler Thromb Vasc Biol. 2010
  PubMed ID: 20448211
   
  
• Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection.
  Fulton RB, Meyerholz DK, Varga SM
  J Immunol. 2010
  PubMed ID: 20639494
   
  
• Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood.
  Bottema RW, Kerkhof M, Reijmerink NE, Thijs C, Smit HA, van Schayck CP, Brunekreef B, van Oosterhout AJ, Postma DS, Koppelman GH
  J Allergy Clin Immunol. 2010
  PubMed ID: 20599261
   
  
• Spontaneous autoimmune dacryoadenitis in aged CD25KO mice.
  Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS
  Am J Pathol. 2010
  PubMed ID: 20566743
   
  
• Tissue expression of interleukin 2 (IL-2) and IL-2 receptor (IL-2R(alpha)/CD25) in non-Hodgkin B-cell lymphomas in children: correlations with clinical data.
  Kasprzak A, Spachacz R, Wachowiak J, Stefańska K, Kaczmarek E, Zabel M
  J Pediatr Hematol Oncol. 2010
  PubMed ID: 20562654
   
  
• Epigallocatechin-3-gallate directly suppresses T cell proliferation through impaired IL-2 utilization and cell cycle progression.
  Pae M, Ren Z, Meydani M, Shang F, Meydani SN, Wu D
  J Nutr. 2010
  PubMed ID: 20534878
   
  
• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
  Plant D, Flynn E, Mbarek H, Dieudé P, Cornelis F, Arlestig L, Dahlqvist SR, Goulielmos G, Boumpas DT, Sidiropoulos P, Johansen JS, Ørnbjerg LM, Hetland ML, Klareskog L, Filer A, Buckley CD, Raza K, Witte T, Schmidt RE, Worthington J
  Ann Rheum Dis. 2010
  PubMed ID: 20498205
   
  
• In vitro enhanced chemotaxis of CD25+ mononuclear cells in patients with familial IgAN through glomerulotubular interactions.
  Tam KY, Leung JC, Chan LY, Lam MF, Tang SC, Lai KN
  Am J Physiol Renal Physiol. 2010
  PubMed ID: 20484297
   
  
• Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis.
  Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L
  Clin Immunol. 2010
  PubMed ID: 20403730
   
  
• Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
  Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM
  Nature. 2010
  PubMed ID: 20596022
   
  
• Early signals during CD8(+) T cell priming regulate the generation of central memory cells.
  Obar JJ, Lefrançois L
  J Immunol. 2010
  PubMed ID: 20519649
   
  
• Monocyte IL-2Ralpha expression is associated with thrombosis and the JAK2V617F mutation in myeloproliferative neoplasms.
  Goette NP, Lev PR, Heller PG, Kornblihtt LI, Korin L, Molinas FC, Marta RF
  Cytokine. 2010
  PubMed ID: 20483636
   
  
• Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells.
  Krieg C, Létourneau S, Pantaleo G, Boyman O
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20547866
   
  
• Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.
  Mitchell DM, Ravkov EV, Williams MA
  J Immunol. 2010
  PubMed ID: 20483725
   
  
• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
  Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
  Pediatr Pulmonol. 2010
  PubMed ID: 20503287
   
  
• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
  Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
  Nat Genet. 2010
  PubMed ID: 20453842
   
  
• Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.
  Wildbaum G, Zohar Y, Karin N
  Am J Pathol. 2010
  PubMed ID: 20382706
   
  
• Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
  Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA
  N Engl J Med. 2010
  PubMed ID: 20410501
   
  
• Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
  Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20452482
   
  
• Impact of Basiliximab on regulatory T-cells early after kidney transplantation: down-regulation of CD25 by receptor modulation.
  Vondran FW, Timrott K, Tross J, Kollrich S, Schwarz A, Lehner F, Klempnauer J, Becker T, Schwinzer R
  Transpl Int. 2010
  PubMed ID: 19951265
   
  
• Impact of immunosuppressants on the therapeutic efficacy of in vitro-expanded CD4+CD25+Foxp3+ regulatory T cells in allotransplantation.
  Lim DG, Koo SK, Park YH, Kim Y, Kim HM, Park CS, Kim SC, Han DJ
  Transplantation. 2010
  PubMed ID: 20305583
   
  
• Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.
  Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM
  Am J Hum Genet. 2010
  PubMed ID: 20362271
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Characterization of rabbit antithymocyte globulins-induced CD25+ regulatory T cells from cells of patients with end-stage renal disease.
  Sewgobind VD, van der Laan LJ, Kho MM, Kraaijeveld R, Korevaar SS, van Dam T, Ijzermans JN, Weimar W, Baan CC
  Transplantation. 2010
  PubMed ID: 20164820
   
  
• The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
  Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T, Bunn D, Worthington J, Symmons D, Barton A
  Rheumatology (Oxford). 2010
  PubMed ID: 20219786
   
  
• [Haplotypes in the IL2RA region associated with diabetes and expression of the IL2RA protein on lymphocytes populations]
  Plagnol V
  Med Sci (Paris). 2010
  PubMed ID: 20346270
   
  
• Decreased CD4+CD25+ cells and increased dimeric IgA-producing cells in tonsils in IgA nephropathy.
  Huang H, Peng Y, Liu H, Yang X, Liu F
  J Nephrol. 2010
  PubMed ID: 20213609
   
  
• Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice.
  McGee HS, Edwan JH, Agrawal DK
  Am J Respir Cell Mol Biol. 2010
  PubMed ID: 19448155
   
  
• Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
  Cavanillas ML, Alcina A, Núñez C, de Las Heras V, Fernández-Arquero M, Bartolomé M, de la Concha EG, Fernández O, Arroyo R, Matesanz F, Urcelay E
  Eur J Hum Genet. 2010
  PubMed ID: 20179739
   
  
• Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
  Ross JA, Cheng H, Nagy ZS, Frost JA, Kirken RA
  J Biol Chem. 2010
  PubMed ID: 19923221
   
  
• IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
  Létourneau S, van Leeuwen EM, Krieg C, Martin C, Pantaleo G, Sprent J, Surh CD, Boyman O
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20133862
   
  
• Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab.
  Du J, Yang H, Zhang D, Wang J, Guo H, Peng B, Guo Y, Ding J
  J Immunol. 2010
  PubMed ID: 20032294
   
  
• Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+ T-regulatory cells.
  Matta B, Jha P, Bora PS, Bora NS
  Immunol Cell Biol. 2010
  PubMed ID: 19884905
   
  
• Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.
  Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R
  Immunity. 2010
  PubMed ID: 20096608
   
  
• Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
  Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A
  Immunity. 2010
  PubMed ID: 20096607
   
  
• CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses.
  Obar JJ, Molloy MJ, Jellison ER, Stoklasek TA, Zhang W, Usherwood EJ, Lefrançois L
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 19966302
   
  
• Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.
  Lu L, Zhou X, Wang J, Zheng SG, Horwitz DA
  PLoS One. 2010
  PubMed ID: 21179414
   
  
• Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells.
  Borges TJ, Porto BN, Teixeira CA, Rodrigues M, Machado FD, Ornaghi AP, de Souza AP, Maito F, Pavanelli WR, Silva JS, Bonorino C
  PLoS One. 2010
  PubMed ID: 21170379
   
  
• CD4+CD25+Foxp3+ regulatory T cells depletion may attenuate the development of silica-induced lung fibrosis in mice.
  Liu F, Liu J, Weng D, Chen Y, Song L, He Q, Chen J
  PLoS One. 2010
  PubMed ID: 21072213
   
  
• L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
  Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
  Nephron Clin Pract. 2010
  PubMed ID: 20424473
   
  
• Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.
  Jensen CJ, Stankovich J, Van der Walt A, Bahlo M, Taylor BV, van der Mei IA, Foote SJ, Kilpatrick TJ, Johnson LJ, Wilkins E, Field J, Danoy P, Brown MA, Australian and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), Rubio JP, Butzkueven H
  PLoS One. 2010
  PubMed ID: 20368992
   
  
• Plasmodium vivax: induction of CD4+CD25+FoxP3+ regulatory T cells during infection are directly associated with level of circulating parasites.
  Bueno LL, Morais CG, Araújo FF, Gomes JA, Corrêa-Oliveira R, Soares IS, Lacerda MV, Fujiwara RT, Braga EM
  PLoS One. 2010
  PubMed ID: 20224778
   
  
• Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
  Ryckman KK, Morken NH, White MJ, Velez DR, Menon R, Fortunato SJ, Magnus P, Williams SM, Jacobsson B
  PLoS One. 2010
  PubMed ID: 20140262
   
  
• GATA-3 is required for early T lineage progenitor development.
  Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD
  J Exp Med. 2009
  PubMed ID: 19934022
   
  
• Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score.
  De Jager PL, Chibnik LB, Cui J, Reischl J, Lehr S, Simon KC, Aubin C, Bauer D, Heubach JF, Sandbrink R, Tyblova M, Lelkova P, Steering committee of the BENEFIT study, Steering committee of the BEYOND study, Steering committee of the LTF study, Steering committee of the CCR1 study, Havrdova E, Pohl C, Horakova D, Ascherio A, Hafler DA, Karlson EW
  Lancet Neurol. 2009
  PubMed ID: 19879194
   
  
• Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes.
  Quaedackers ME, Baan CC, Weimar W, Hoogduijn MJ
  Eur J Immunol. 2009
  PubMed ID: 19798683
   
  
• Dec2 promotes Th2 cell differentiation by enhancing IL-2R signaling.
  Liu Z, Li Z, Mao K, Zou J, Wang Y, Tao Z, Lin G, Tian L, Ji Y, Wu X, Zhu X, Sun S, Chen W, Xiang C, Sun B
  J Immunol. 2009
  PubMed ID: 19880450
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.
  Hoppenbrouwers IA, Aulchenko YS, Janssens AC, Ramagopalan SV, Broer L, Kayser M, Ebers GC, Oostra BA, van Duijn CM, Hintzen RQ
  J Hum Genet. 2009
  PubMed ID: 19834503
   
  
• Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population.
  Kurreeman FA, Daha NA, Chang M, Catanese JJ, Begovich AB, Huizinga TW, Toes RE
  Ann Rheum Dis. 2009
  PubMed ID: 19822714
   
  
• Multiple sclerosis susceptibility alleles in African Americans.
  Johnson BA, Wang J, Taylor EM, Caillier SJ, Herbert J, Khan OA, Cross AH, De Jager PL, Gourraud PA, Cree BC, Hauser SL, Oksenberg JR
  Genes Immun. 2009
  PubMed ID: 19865102
   
  
• CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury.
  D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, Britos MF, Pipeling MR, Brower RG, Tuder RM, McDyer JF, King LS
  J Clin Invest. 2009
  PubMed ID: 19770521
   
  
• Dynamic development of homing receptor expression and memory cell differentiation of infant CD4+CD25high regulatory T cells.
  Grindebacke H, Stenstad H, Quiding-Järbrink M, Waldenström J, Adlerberth I, Wold AE, Rudin A
  J Immunol. 2009
  PubMed ID: 19734224
   
  
• Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells.
  Cao Z, Wara AK, Icli B, Sun X, Packard RR, Esen F, Stapleton CJ, Subramaniam M, Kretschmer K, Apostolou I, von Boehmer H, Hansson GK, Spelsberg TC, Libby P, Feinberg MW
  J Biol Chem. 2009
  PubMed ID: 19602726
   
  
• T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
  Terauchi M, Li JY, Bedi B, Baek KH, Tawfeek H, Galley S, Gilbert L, Nanes MS, Zayzafoon M, Guldberg R, Lamar DL, Singer MA, Lane TF, Kronenberg HM, Weitzmann MN, Pacifici R
  Cell Metab. 2009
  PubMed ID: 19723499
   
  
• Tolerogenic semimature dendritic cells induce effector T-cell hyporesponsiveness by the activation of antigen-specific CD4+ CD25+ T-regulatory cells.
  Fu BM, He XS, Yu S, Hu AB, Ma Y, Wu LW, Tam NL, Huang JF
  Exp Clin Transplant. 2009
  PubMed ID: 19715524
   
  
• CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2.
  Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19666526
   
  
• Increased interleukin-10 production without expansion of CD4+CD25+ T-regulatory cells in early stable renal transplant patients on calcineurin inhibitors.
  Mittal SK, Sharma RK, Gupta A, Naik S
  Transplantation. 2009
  PubMed ID: 19667950
   
  
• Extracorporeal photophoresis augments function of CD4+CD25+FoxP3+ regulatory T cells by triggering adenosine production.
  Schmitt S, Johnson TS, Karakhanova S, Näher H, Mahnke K, Enk AH
  Transplantation. 2009
  PubMed ID: 19667946
   
  
• Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.
  Saint Fleur S, Hoshino A, Kondo K, Egawa T, Fujii H
  Blood. 2009
  PubMed ID: 19528538
   
  
• [Altered frequency of CD4+CD25-Foxp3+ T cells in patients with systemic lupus erythematosus]
  Yan B, Liu Y, Xie QB, Liu G
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
  PubMed ID: 19664391
   
  
• Analysis of variation in the IL7RA and IL2RA genes in atopic dermatitis.
  Hoffjan S, Beygo J, Akkad DA, Parwez Q, Petrasch-Parwez E, Epplen JT
  J Dermatol Sci. 2009
  PubMed ID: 19523791
   
  
• Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
  Gut. 2009
  PubMed ID: 19240061
   
  
• Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis.
  Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, Zeft AS, Bohnsack JF, Jorde LB
  Arthritis Rheum. 2009
  PubMed ID: 19565500
   
  
• Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
  Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)
  Nat Genet. 2009
  PubMed ID: 19525955
   
  
• Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
  De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR
  Nat Genet. 2009
  PubMed ID: 19525953
   
  
• CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2.
  Pedersen AE, Lauritsen JP
  Scand J Immunol. 2009
  PubMed ID: 19522766
   
  
• Correlation between the degree of immune activation, production of IL-2 and FOXP3 expression in CD4+CD25+ T regulatory cells in HIV-1 infected persons under HAART.
  Terzieva V, Popova D, Kicheva M, Todorova Y, Markova R, Martinova F, Elenkov I, Yankova M
  Int Immunopharmacol. 2009
  PubMed ID: 19303058
   
  
• Local effector failure in mesothelioma is not mediated by CD4+ CD25+ T-regulator cells.
  Jackaman C, Cornwall S, Lew AM, Zhan Y, Robinson BW, Nelson DJ
  Eur Respir J. 2009
  PubMed ID: 19251786
   
  
• Fine mapping of multiple sclerosis susceptibility genes provides evidence of allelic heterogeneity at the IL2RA locus.
  Perera D, Stankovich J, Butzkueven H, Taylor BV, Foote SJ, Kilpatrick TJ, Rubio JP
  J Neuroimmunol. 2009
  PubMed ID: 19375175
   
  
• Risk alleles for multiple sclerosis in multiplex families.
  D'Netto MJ, Ward H, Morrison KM, Ramagopalan SV, Dyment DA, DeLuca GC, Handunnetthi L, Sadovnick AD, Ebers GC
  Neurology. 2009
  PubMed ID: 19506219
   
  
• Characterization of Multiple Sclerosis candidate gene expression kinetics in rat experimental autoimmune encephalomyelitis.
  Thessen Hedreul M, Gillett A, Olsson T, Jagodic M, Harris RA
  J Neuroimmunol. 2009
  PubMed ID: 19269041
   
  
• Serum soluble interleukin-2 receptor levels in patients with malignant lymphoma of bone.
  Akahane T, Shimizu T, Isobe K, Yoshimura Y, Kato H
  J Orthop Sci. 2009
  PubMed ID: 19499289
   
  
• A positive feedback loop of IL-21 signaling provoked by homeostatic CD4+CD25- T cell expansion is essential for the development of arthritis in autoimmune K/BxN mice.
  Jang E, Cho SH, Park H, Paik DJ, Kim JM, Youn J
  J Immunol. 2009
  PubMed ID: 19342640
   
  
• Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells.
  Huber S, Stahl FR, Schrader J, Lüth S, Presser K, Carambia A, Flavell RA, Werner S, Blessing M, Herkel J, Schramm C
  J Immunol. 2009
  PubMed ID: 19342638
   
  
• Reciprocal modulation of circulating CD4+CD25+bright T cells induced by extracorporeal photochemotherapy in cutaneous T-cell lymphoma and chronic graft-versus-host-disease patients.
  Quaglino P, Comessatti A, Ponti R, Peroni A, Mola F, Fierro MT, Savoia P, Novelli M, Bernengo MG
  Int J Immunopathol Pharmacol. 2009
  PubMed ID: 19505389
   
  
• Immunophenotypic analysis of CD103+ B-lymphoproliferative disorders: hairy cell leukemia and its mimics.
  Dong HY, Weisberger J, Liu Z, Tugulea S
  Am J Clin Pathol. 2009
  PubMed ID: 19289595
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
• Expression of TCTP antisense in CD25(high) regulatory T cells aggravates cuff-injured vascular inflammation.
  Xiong Z, Yan Y, Song J, Fang P, Yin Y, Yang Y, Cowan A, Wang H, Yang XF
  Atherosclerosis. 2009
  PubMed ID: 18789801
   
  
• Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
  Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu SN, Knoops L, Renauld JC
  J Biol Chem. 2009
  PubMed ID: 19139102
   
  
• Variation in the IL7RA and IL2RA genes in German multiple sclerosis patients.
  Akkad DA, Hoffjan S, Petrasch-Parwez E, Beygo J, Gold R, Epplen JT
  J Autoimmun. 2009
  PubMed ID: 19231135
   
  
• Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma.
  Matsumoto K, Inoue H, Fukuyama S, Kan-O K, Eguchi-Tsuda M, Matsumoto T, Moriwaki A, Nakano T, Nakanishi Y
  Respirology. 2009
  PubMed ID: 19192224
   
  
• Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus.
  Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C
  J Immunol. 2009
  PubMed ID: 19155519
   
  
• Biomarkers for nononcologic gastrointestinal diseases.
  Katial R
  Immunol Allergy Clin North Am. 2009
  PubMed ID: 19141347
   
  
• Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
  Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
  Am J Obstet Gynecol. 2009
  PubMed ID: 19019335
   
  
• IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.
  Duré M, Macian F
  Mol Immunol. 2009
  PubMed ID: 18990450
   
  
• Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
  Brusko TM, Wasserfall CH, Hulme MA, Cabrera R, Schatz D, Atkinson MA
  PLoS One. 2009
  PubMed ID: 19956753
   
  
• Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
  Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH
  J Transl Med. 2009
  PubMed ID: 19849846
   
  
• [The expression of CD25 in phytohemagglutinin- or interleukin-2-stimulated human peripheral blood lymphocytes]
  Zenin VV, Aksenov ND, Shatrova AN, Marakhova II
  Tsitologiia. 2009
  PubMed ID: 19637754
   
  
• If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
  Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19527514
   
  
• Interleukin-6 and soluble interleukin-2 receptor alpha-markers of inflammation in patients with psoriatic arthritis?
  Alenius GM, Eriksson C, Rantapää Dahlqvist S
  Clin Exp Rheumatol. 2009
  PubMed ID: 19327240
   
  
• Expression of interleukin-21, interleukin-21 receptor alpha and related type I cytokines by intravascular graft leukocytes during acute renal allograft rejection.
  Hecker A, Kaufmann A, Hecker M, Padberg W, Grau V
  Immunobiology. 2009
  PubMed ID: 19159826
   
  
• Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner.
  Jiang G, Yang HR, Wang L, Wildey GM, Fung J, Qian S, Lu L
  Transplantation. 2008
  PubMed ID: 19077880
   
  
• Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.
  Wilson EB, Livingstone AM
  J Immunol. 2008
  PubMed ID: 19017930
   
  
• Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
  Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S
  Am J Pathol. 2008
  PubMed ID: 19008373
   
  
• CD25+ T cells induce Helicobacter pylori-specific CD25- T-cell anergy but are not required to maintain persistent hyporesponsiveness.
  Stuller KA, Ding H, Redline RW, Czinn SJ, Blanchard TG
  Eur J Immunol. 2008
  PubMed ID: 19003932
   
  
• Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
  Cooper JD, Smyth DJ, Smiles AM, Plagnol V, Walker NM, Allen JE, Downes K, Barrett JC, Healy BC, Mychaleckyj JC, Warram JH, Todd JA
  Nat Genet. 2008
  PubMed ID: 18978792
   
  
• FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal.
  Pons JA, Revilla-Nuin B, Baroja-Mazo A, Ramírez P, Martínez-Alarcón L, Sánchez-Bueno F, Robles R, Rios A, Aparicio P, Parrilla P
  Transplantation. 2008
  PubMed ID: 19034005
   
  
• Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers.
  Shibata K, Yamada H, Nakamura R, Sun X, Itsumi M, Yoshikai Y
  J Immunol. 2008
  PubMed ID: 18941182
   
  
• Tolerance to melanin-associated antigen in autoimmune uveitis is mediated by CD4+CD25+ T-regulatory cells.
  Matta B, Jha P, Bora PS, Bora NS
  Am J Pathol. 2008
  PubMed ID: 18832572
   
  
• High-level expression of a functional humanized single-chain variable fragment antibody against CD25 in Pichia pastoris.
  Wan L, Cai H, Yang H, Lu Y, Li Y, Li X, Li S, Zhang J, Li Y, Cheng J, Lu X
  Appl Microbiol Biotechnol. 2008
  PubMed ID: 18704398
   
  
• Depletion of CD4(+)CD25(+) regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma.
  Chen YL, Fang JH, Lai MD, Shan YS
  World J Gastroenterol. 2008
  PubMed ID: 18855977
   
  
• E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
  Jia J, Dai M, Zhuang Y
  Eur J Immunol. 2008
  PubMed ID: 18958875
   
  
• Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.
  Rubio JP, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C, Bahlo M, Perera D, Johnson LJ, Tait BD, Varney MD, Speed TP, Taylor BV, Foote SJ, Butzkueven H, Kilpatrick TJ
  Genes Immun. 2008
  PubMed ID: 18650830
   
  
• Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology.
  van Hamburg JP, de Bruijn MJ, Ribeiro de Almeida C, van Zwam M, van Meurs M, de Haas E, Boon L, Samsom JN, Hendriks RW
  Eur J Immunol. 2008
  PubMed ID: 18792410
   
  
• Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.
  Dhiman N, Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA
  Tissue Antigens. 2008
  PubMed ID: 18715339
   
  
• IL-2 receptor beta-chain signaling controls immunosuppressive CD4+ T cells in the draining lymph nodes and lung during allergic airway inflammation in vivo.
  Doganci A, Karwot R, Maxeiner JH, Scholtes P, Schmitt E, Neurath MF, Lehr HA, Ho IC, Finotto S
  J Immunol. 2008
  PubMed ID: 18641329
   
  
• SCART scavenger receptors identify a novel subset of adult gammadelta T cells.
  Kisielow J, Kopf M, Karjalainen K
  J Immunol. 2008
  PubMed ID: 18641307
   
  
• Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3.
  Zheng Y, Manzotti CN, Burke F, Dussably L, Qureshi O, Walker LS, Sansom DM
  J Immunol. 2008
  PubMed ID: 18641304
   
  
• IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.
  Fragale A, Gabriele L, Stellacci E, Borghi P, Perrotti E, Ilari R, Lanciotti A, Remoli AL, Venditti M, Belardelli F, Battistini A
  J Immunol. 2008
  PubMed ID: 18641303
   
  
• Anti-CD25 antibodies affect cytokine synthesis pattern of human dendritic cells and decrease their ability to prime allogeneic CD4+ T cells.
  Mnasria K, Lagaraine C, Velge-Roussel F, Oueslati R, Lebranchu Y, Baron C
  J Leukoc Biol. 2008
  PubMed ID: 18467656
   
  
• Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.
  Skinningsrud B, Husebye ES, Pearce SH, McDonald DO, Brandal K, Bøe Wolff A, Løvås K, Egeland T, Undlien DE
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18593762
   
  
• A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells.
  Bayer AL, Lee JY, de la Barrera A, Surh CD, Malek TR
  J Immunol. 2008
  PubMed ID: 18566388
   
  
• TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis.
  Wang H, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, Röhrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K
  J Clin Invest. 2008
  PubMed ID: 18521187
   
  
• Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection.
  Perrella A, Vitiello L, Atripaldi L, Sbreglia C, Grattacaso S, Bellopede P, Patarino T, Morelli G, Altamura S, Racioppi L, Perrella O
  J Gastroenterol Hepatol. 2008
  PubMed ID: 17645467
   
  
• Aerobic training increases the stimulated percentage of CD4+CD25+ in older men but not older women.
  Broadbent S, Gass G
  Eur J Appl Physiol. 2008
  PubMed ID: 18204854
   
  
• IL-17 production elicited by allo-major histocompatibility complex class II recognition depends on CD25posCD4pos T cells.
  Benghiat FS, Craciun L, De Wilde V, Dernies T, Kubjak C, Lhomme F, Goldman M, Le Moine A
  Transplantation. 2008
  PubMed ID: 18408572
   
  
• CD127 and CD25 expression defines CD4+ T cell subsets that are differentially depleted during HIV infection.
  Dunham RM, Cervasi B, Brenchley JM, Albrecht H, Weintrob A, Sumpter B, Engram J, Gordon S, Klatt NR, Frank I, Sodora DL, Douek DC, Paiardini M, Silvestri G
  J Immunol. 2008
  PubMed ID: 18390743
   
  
• The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.
  Ramsey C, Rubinstein MP, Kim DM, Cho JH, Sprent J, Surh CD
  J Immunol. 2008
  PubMed ID: 18390713
   
  
• Colocalization of the IL-12 receptor and FcgammaRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma.
  Kondadasula SV, Roda JM, Parihar R, Yu J, Lehman A, Caligiuri MA, Tridandapani S, Burry RW, Carson WE
  Blood. 2008
  PubMed ID: 18174382
   
  
• Serum soluble interleukin-2 receptor alpha in systemic lupus erythematosus.
  El-Shafey EM, El-Nagar GF, El-Bendary AS, Sabry AA, Selim AG
  Iran J Kidney Dis. 2008
  PubMed ID: 19377213
   
  
• IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.
  Weber F, Fontaine B, Cournu-Rebeix I, Kroner A, Knop M, Lutz S, Müller-Sarnowski F, Uhr M, Bettecken T, Kohli M, Ripke S, Ising M, Rieckmann P, Brassat D, Semana G, Babron MC, Mrejen S, Gout C, Lyon-Caen O, Yaouanq J, Edan G, Clanet M, Holsboer F, Clerget-Darpoux F, Müller-Myhsok B
  Genes Immun. 2008
  PubMed ID: 18354419
   
  
• CD4+CD25+ regulatory T cells specific for a thymus-expressed antigen prevent the development of anaphylaxis to self.
  Scabeni S, Lapilla M, Musio S, Gallo B, Ciusani E, Steinman L, Mantegazza R, Pedotti R
  J Immunol. 2008
  PubMed ID: 18354164
   
  
• Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice.
  Zheng L, Sharma R, Kung JT, Deshmukh US, Jarjour WN, Fu SM, Ju ST
  Int Immunol. 2008
  PubMed ID: 18310063
   
  
• CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H.
  Bloom DD, Chang Z, Fechner JH, Dar W, Polster SP, Pascual J, Turka LA, Knechtle SJ
  Am J Transplant. 2008
  PubMed ID: 18261176
   
  
• Circulating naïve and CD4+CD25high regulatory T cells in patients with autoimmune pancreatitis.
  Miyoshi H, Uchida K, Taniguchi T, Yazumi S, Matsushita M, Takaoka M, Okazaki K
  Pancreas. 2008
  PubMed ID: 18376303
   
  
• Nanometer-scale organization of the alpha subunits of the receptors for IL2 and IL15 in human T lymphoma cells.
  de Bakker BI, Bodnár A, van Dijk EM, Vámosi G, Damjanovich S, Waldmann TA, van Hulst NF, Jenei A, Garcia-Parajo MF
  J Cell Sci. 2008
  PubMed ID: 18287585
   
  
• Proportional change of CD4+CD25+ regulatory T cells in decidua and peripheral blood in unexplained recurrent spontaneous abortion patients.
  Yang H, Qiu L, Chen G, Ye Z, Lü C, Lin Q
  Fertil Steril. 2008
  PubMed ID: 17543960
   
  
• CD4+CD25+ regulatory T cells selectively diminish systemic autoreactivity in arthritic K/BxN mice.
  Kang SM, Jang E, Paik DJ, Jang YJ, Youn J
  Mol Cells. 2008
  PubMed ID: 18319615
   
  
• Ex vivo generated regulatory T cells modulate experimental autoimmune myasthenia gravis.
  Aricha R, Feferman T, Fuchs S, Souroujon MC
  J Immunol. 2008
  PubMed ID: 18250419
   
  
• Ex vivo-expanded natural CD4+CD25+ regulatory T cells synergize with host T-cell depletion to promote long-term survival of allografts.
  Xia G, He J, Leventhal JR
  Am J Transplant. 2008
  PubMed ID: 18190656
   
  
• A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor.
  Osusky M, Teschke L, Wang X, Wong K, Buckley JT
  J Biol Chem. 2008
  PubMed ID: 17981806
   
  
• Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement.
  Owaidah TM, Rawas FI, Al Khayatt MF, Elkum NB
  Hematol Oncol Stem Cell Ther. 2008
  PubMed ID: 20063526
   
  
• Alterations in the peripheral blood lymphocyte CD25 and Ki67 indices in renal cell carcinoma and their significance: a preliminary study.
  Li Y, Chen YR, Ju J, Shi B
  Urol Int. 2008
  PubMed ID: 19077408
   
  
• Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
  Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
  PLoS ONE. 2008
  PubMed ID: 18818748
   
  
• Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression.
  Wang R, Wan Q, Kozhaya L, Fujii H, Unutmaz D
  PLoS ONE. 2008
  PubMed ID: 18628982
   
  
• CD25 expression on cutaneous mast cells from adult patients presenting with urticaria pigmentosa is predictive of systemic mastocytosis.
  Hollmann TJ, Brenn T, Hornick JL
  Am J Surg Pathol. 2008
  PubMed ID: 18162781
   
  
• Decreased CD4+CD25+bright T cells in peripheral blood of patients with primary Sjogren's syndrome.
  Liu MF, Lin LH, Weng CT, Weng MY
  Lupus. 2008
  PubMed ID: 18089681
   
  
• Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes.
  Joffre O, Santolaria T, Calise D, Al Saati T, Hudrisier D, Romagnoli P, van Meerwijk JP
  Nat Med. 2008
  PubMed ID: 18066074
   
  
• Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134.
  Nolte-'t Hoen EN, Boot EP, Wagenaar-Hilbers JP, van Bilsen JH, Arkesteijn GJ, Storm G, Everse LA, van Eden W, Wauben MH
  J Leukoc Biol. 2008
  PubMed ID: 17928458
   
  
• Chronic plasminogen activator inhibitor-1 (PAI-1) overexpression dampens CD25+ lymphocyte recruitment after lipopolysaccharide endotoxemia in mouse lung.
  Poggi M, Paulmyer-Lacroix O, Verdier M, Peiretti F, Bastelica D, Boucraut J, Lijnen HR, Juhan-Vague I, Alessi MC
  J Thromb Haemost. 2007
  PubMed ID: 17848179
   
  
• Immunoreactivity for CD25 in gastrointestinal mucosal mast cells is specific for systemic mastocytosis.
  Hahn HP, Hornick JL
  Am J Surg Pathol. 2007
  PubMed ID: 18059223
   
  
• The influence of immuosuppressive therapy on the development of CD4+CD25+ T cells after renal transplantation.
  Korczak-Kowalska G, Wierzbicki P, Bocian K, Klosowska D, Niemczyk M, Wyzgal J, Korecka A, Durlik M, Chmura A, Paczek L, Górski A
  Transplant Proc. 2007
  PubMed ID: 18021968
   
  
• The frequency and suppressor function of CD4+CD25highFoxp3+ T cells in the circulation of patients with squamous cell carcinoma of the head and neck.
  Strauss L, Bergmann C, Gooding W, Johnson JT, Whiteside TL
  Clin Cancer Res. 2007
  PubMed ID: 17975141
   
  
• Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4+CD25+ cells in the draining lymph nodes.
  Gorman S, Kuritzky LA, Judge MA, Dixon KM, McGlade JP, Mason RS, Finlay-Jones JJ, Hart PH
  J Immunol. 2007
  PubMed ID: 17947703
   
  
• The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study.
  Zwickey H, Brush J, Iacullo CM, Connelly E, Gregory WL, Soumyanath A, Buresh R
  Phytother Res. 2007
  PubMed ID: 17661330
   
  
• Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo.
  Powell DJ, Felipe-Silva A, Merino MJ, Ahmadzadeh M, Allen T, Levy C, White DE, Mavroukakis S, Kreitman RJ, Rosenberg SA, Pastan I
  J Immunol. 2007
  PubMed ID: 17878392
   
  
• CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo.
  Taylor MD, Harris A, Babayan SA, Bain O, Culshaw A, Allen JE, Maizels RM
  J Immunol. 2007
  PubMed ID: 17878360
   
  
• CD70+ non-Hodgkin lymphoma B cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25 T cells.
  Yang ZZ, Novak AJ, Ziesmer SC, Witzig TE, Ansell SM
  Blood. 2007
  PubMed ID: 17615291
   
  
• Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host.
  Easterbrook JD, Zink MC, Klein SL
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17878294
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
  Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
  J Infect Dis. 2007
  PubMed ID: 17703412
   
  
• Circulating CD4+CD25+ T cells in rheumatic mitral stenosis.
  Yildiz A, Ozeke O, Aras D, Balci M, Deveci B, Ergun K, Topaloglu S, Dogan M, Ozcan F, Sokmen Y, Sasmaz A, Korkmaz S
  J Heart Valve Dis. 2007
  PubMed ID: 17944116
   
  
• Regulation of interleukin-2 signaling by fatty acids in human lymphocytes.
  Gorjão R, Hirabara SM, de Lima TM, Cury-Boaventura MF, Curi R
  J Lipid Res. 2007
  PubMed ID: 17592174
   
  
• Risk alleles for multiple sclerosis identified by a genomewide study.
  International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL
  N Engl J Med. 2007
  PubMed ID: 17660530
   
  
• An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
  Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J
  J Exp Med. 2007
  PubMed ID: 17664294
   
  
• Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours.
  Kasprzak A, Olejniczak K, Przybyszewska W, Zabel M
  Folia Morphol (Warsz). 2007
  PubMed ID: 17985312
   
  
• Mesenchymal cells are required for functional development of thymic epithelial cells.
  Itoi M, Tsukamoto N, Yoshida H, Amagai T
  Int Immunol. 2007
  PubMed ID: 17625108
   
  
• Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients.
  Codarri L, Vallotton L, Ciuffreda D, Venetz JP, Garcia M, Hadaya K, Buhler L, Rotman S, Pascual M, Pantaleo G
  J Exp Med. 2007
  PubMed ID: 17591854
   
  
• IL-2Rbeta links IL-2R signaling with Foxp3 expression.
  Soper DM, Kasprowicz DJ, Ziegler SF
  Eur J Immunol. 2007
  PubMed ID: 17559173
   
  
• Expression and function of the IL-2 receptor in activated human plasmacytoid dendritic cells.
  Naranjo-Gómez M, Oliva H, Climent N, Fernández MA, Ruiz-Riol M, Bofill M, Gatell JM, Gallart T, Pujol-Borrell R, Borràs FE
  Eur J Immunol. 2007
  PubMed ID: 17523134
   
  
• OX40-mediated differentiation to effector function requires IL-2 receptor signaling but not CD28, CD40, IL-12Rbeta2, or T-bet.
  Williams CA, Murray SE, Weinberg AD, Parker DC
  J Immunol. 2007
  PubMed ID: 17548606
   
  
• Human CD4+CD25+ regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells.
  Kim YG, Lee CK, Nah SS, Mun SH, Yoo B, Moon HB
  Biochem Biophys Res Commun. 2007
  PubMed ID: 17462597
   
  
• Differential role of IL-2R signaling for CD8+ T cell responses in acute and chronic viral infections.
  Bachmann MF, Wolint P, Walton S, Schwarz K, Oxenius A
  Eur J Immunol. 2007
  PubMed ID: 17492805
   
  
• Hepatocellular carcinoma cell supernatants increase expansion and function of CD4(+)CD25(+) regulatory T cells.
  Cao M, Cabrera R, Xu Y, Firpi R, Zhu H, Liu C, Nelson DR
  Lab Invest. 2007
  PubMed ID: 17372588
   
  
• Dose-dependent recruitment of CD25+ and CD26+ T cells in a novel F344 rat model of asthma.
  Skripuletz T, Schmiedl A, Schade J, Bedoui S, Glaab T, Pabst R, von Hörsten S, Stephan M
  Am J Physiol Lung Cell Mol Physiol. 2007
  PubMed ID: 17351063
   
  
• IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility.
  Matesanz F, Caro-Maldonado A, Fedetz M, Fernández O, Milne RL, Guerrero M, Delgado C, Alcina A
  J Neurol. 2007
  PubMed ID: 17420929
   
  
• CD4+ CD25+ regulatory T cells suppress CD4+ T-cell function and inhibit the development of Plasmodium berghei-specific TH1 responses involved in cerebral malaria pathogenesis.
  Nie CQ, Bernard NJ, Schofield L, Hansen DS
  Infect Immun. 2007
  PubMed ID: 17325053
   
  
• Correlation of the CD4+CD25high T-regulatory cells in recipients and their corresponding donors to acute GVHD.
  Zhai Z, Sun Z, Li Q, Zhang A, Liu H, Xu J, Xu X, Geng L, Harris D, Hu S, Wang Y
  Transpl Int. 2007
  PubMed ID: 17313446
   
  
• Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients.
  Schmidt-Lucke C, Aicher A, Romagnani P, Gareis B, Romagnani S, Zeiher AM, Dimmeler S
  Am J Physiol Heart Circ Physiol. 2007
  PubMed ID: 17237241
   
  
• Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis.
  Nylén S, Maurya R, Eidsmo L, Manandhar KD, Sundar S, Sacks D
  J Exp Med. 2007
  PubMed ID: 17389235
   
  
• Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.
  Bayer AL, Yu A, Malek TR
  J Immunol. 2007
  PubMed ID: 17371960
   
  
• Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells.
  Dooms H, Wolslegel K, Lin P, Abbas AK
  J Exp Med. 2007
  PubMed ID: 17312008
   
  
• The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis.
  Wisnoski N, Chung CS, Chen Y, Huang X, Ayala A
  Shock. 2007
  PubMed ID: 17304105
   
  
• Targeting of CD25 and glucocorticoid-induced TNF receptor family-related gene-expressing T cells differentially modulates asthma risk in offspring of asthmatic and normal mother mice.
  Hubeau C, Apostolou I, Kobzik L
  J Immunol. 2007
  PubMed ID: 17237396
   
  
• A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis.
  Sharma R, Zheng L, Deshmukh US, Jarjour WN, Sung SS, Fu SM, Ju ST
  J Immunol. 2007
  PubMed ID: 17237369
   
  
• Clinical and prognostic significance of cytokine receptor expression in adult acute lymphoblastic leukemia: interleukin-2 receptor alpha-chain predicts a poor prognosis.
  Nakase K, Kita K, Miwa H, Nishii K, Shikami M, Tanaka I, Tsutani H, Ueda T, Nasu K, Kyo T, Dohy H, Shiku H, Katayama N
  Leukemia. 2007
  PubMed ID: 17205058
   
  
• Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus.
  Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN
  Adv Exp Med Biol. 2007
  PubMed ID: 17712998
   
  
• Neuropilin 1 and CD25 co-regulation during early murine thymic differentiation.
  Corbel C, Lemarchandel V, Thomas-Vaslin V, Pelus AS, Agboton C, Roméo PH
  Dev Comp Immunol. 2007
  PubMed ID: 17374393
   
  
• Functional CD25(bright+) alloresponsive T cells in fully immunosuppressed renal allograft recipients.
  Baan CC, Velthuis JH, van Gurp EA, Mol WM, Klepper M, Ijzermans JN, Weimar W
  Clin Transplant. 2007
  PubMed ID: 17302593
   
  
• Peripheral CD4(+)CD25(+) TREG cell counts and the response to extracorporeal photopheresis in lung transplant recipients.
  Meloni F, Cascina A, Miserere S, Perotti C, Vitulo P, Fietta AM
  Transplant Proc. 2007
  PubMed ID: 17275508
   
  
• IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.
  Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA
  J Immunol. 2007
  PubMed ID: 17182565
   
  
• Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.
  Dhiman N, Ovsyannikova IG, Cunningham JM, Vierkant RA, Kennedy RB, Pankratz VS, Poland GA, Jacobson RM
  J Infect Dis. 2007
  PubMed ID: 17152005
   
  
• Decreased expression of CD25 on decidual activated T lymphocytes is not mediated by reduced CD25 messenger ribonucleic acid.
  Chao KH, Wu MY, Yang JH, Chen SU, Yang YS, Ho HN
  Fertil Steril. 2007
  PubMed ID: 17074352
   
  
• Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.
  Sharma R, Zheng L, Guo X, Fu SM, Ju ST, Jarjour WN
  J Autoimmun. 2006
  PubMed ID: 17207605
   
  
• Anti-CD25 mAb administration prevents spontaneous liver transplant tolerance.
  Li W, Carper K, Liang Y, Zheng XX, Kuhr CS, Reyes JD, Perkins DL, Thomson AW, Perkins JD
  Transplant Proc. 2006
  PubMed ID: 17175224
   
  
• Adoptive cell therapy using in vitro generated human CD4+ CD25+ regulatory t cells with indirect allospecificity to promote donor-specific transplantation tolerance.
  Jiang S, Tsang J, Lechler RI
  Transplant Proc. 2006
  PubMed ID: 17175221
   
  
• Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.
  Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL
  J Immunol. 2006
  PubMed ID: 17114466
   
  
• Presence of functional mouse regulatory CD4+CD25+T cells in xenogeneic neonatal porcine thymus-grafted athymic mice.
  Sun Z, Zhao L, Wang H, Sun L, Yi H, Zhao Y
  Am J Transplant. 2006
  PubMed ID: 17062002
   
  
• GATA-3 regulates the development and function of invariant NKT cells.
  Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC
  J Immunol. 2006
  PubMed ID: 17082577
   
  
• B-cell CD25 expression in murine primary and secondary lymphoid tissue.
  Amu S, Gjertsson I, Tarkowski A, Brisslert M
  Scand J Immunol. 2006
  PubMed ID: 17032240
   
  
• Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.
  Kim HP, Imbert J, Leonard WJ
  Cytokine Growth Factor Rev. 2006
  PubMed ID: 16911870
   
  
• Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7.
  Peffault de Latour R, Dujardin HC, Mishellany F, Burlen-Defranoux O, Zuber J, Marques R, Di Santo J, Cumano A, Vieira P, Bandeira A
  Blood. 2006
  PubMed ID: 16763207
   
  
• Expression and function of IL-10R in mononuclear cells from patients with systemic lupus erythematosus.
  Valencia-Pacheco G, Layseca-Espinosa E, Niño-Moreno P, Portales-Pérez DP, Baranda L, Rosenstein Y, Abud-Mendoza C, González-Amaro R
  Scand J Rheumatol. 2006
  PubMed ID: 17062437
   
  
• Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.
  Marie JC, Liggitt D, Rudensky AY
  Immunity. 2006
  PubMed ID: 16973387
   
  
• Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo.
  Vukmanovic-Stejic M, Zhang Y, Cook JE, Fletcher JM, McQuaid A, Masters JE, Rustin MH, Taams LS, Beverley PC, Macallan DC, Akbar AN
  J Clin Invest. 2006
  PubMed ID: 16955142
   
  
• Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency.
  Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB
  J Immunol. 2006
  PubMed ID: 16920911
   
  
• PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs.
  Walsh PT, Buckler JL, Zhang J, Gelman AE, Dalton NM, Taylor DK, Bensinger SJ, Hancock WW, Turka LA
  J Clin Invest. 2006
  PubMed ID: 16917540
   
  
• Role of IFN-gamma in induction of Foxp3 and conversion of CD4+ CD25- T cells to CD4+ Tregs.
  Wang Z, Hong J, Sun W, Xu G, Li N, Chen X, Liu A, Xu L, Sun B, Zhang JZ
  J Clin Invest. 2006
  PubMed ID: 16906223
   
  
• The anti-CD25 monoclonal antibody 7G7/B6, armed with the alpha-emitter 211At, provides effective radioimmunotherapy for a murine model of leukemia.
  Zhang M, Yao Z, Zhang Z, Garmestani K, Talanov VS, Plascjak PS, Yu S, Kim HS, Goldman CK, Paik CH, Brechbiel MW, Carrasquillo JA, Waldmann TA
  Cancer Res. 2006
  PubMed ID: 16912202
   
  
• CD4+25+ regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation.
  Bharat A, Fields RC, Steward N, Trulock EP, Patterson GA, Mohanakumar T
  Am J Transplant. 2006
  PubMed ID: 16889540
   
  
• Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells.
  Pacholczyk R, Ignatowicz H, Kraj P, Ignatowicz L
  Immunity. 2006
  PubMed ID: 16879995
   
  
• Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.
  Almeida AR, Zaragoza B, Freitas AA
  J Immunol. 2006
  PubMed ID: 16785514
   
  
• Levels of circulating regulatory CD4+CD25+ T cells are decreased in breast cancer patients after vaccination with a HER2/neu peptide (E75) and GM-CSF vaccine.
  Hueman MT, Stojadinovic A, Storrer CE, Foley RJ, Gurney JM, Shriver CD, Ponniah S, Peoples GE
  Breast Cancer Res Treat. 2006
  PubMed ID: 16758122
   
  
• Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.
  Williams MA, Tyznik AJ, Bevan MJ
  Nature. 2006
  PubMed ID: 16778891
   
  
• Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.
  Leithäuser F, Meinhardt-Krajina T, Fink K, Wotschke B, Möller P, Reimann J
  Am J Pathol. 2006
  PubMed ID: 16723705
   
  
• Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage.
  Cabarrocas J, Cassan C, Magnusson F, Piaggio E, Mars L, Derbinski J, Kyewski B, Gross DA, Salomon BL, Khazaie K, Saoudi A, Liblau RS
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16709665
   
  
• In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma.
  Beyer M, Kochanek M, Giese T, Endl E, Weihrauch MR, Knolle PA, Classen S, Schultze JL
  Blood. 2006
  PubMed ID: 16410445
   
  
• Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells.
  Liu H, Komai-Koma M, Xu D, Liew FY
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16632602
   
  
• Dynamics of CD4+CD25+ T cells in spleens and mesenteric lymph nodes of mice infected with Schistosoma japonicum.
  Cai XP, Zhang H, Zhang YC, Wang Y, Su C, Ji MJ, Wu HW, Zhu X, Zhang ZS, Wu GL
  Acta Biochim Biophys Sin (Shanghai). 2006
  PubMed ID: 16680369
   
  
• Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitors.
  de Pooter RF, Schmitt TM, de la Pompa JL, Fujiwara Y, Orkin SH, Zúñiga-Pflücker JC
  J Immunol. 2006
  PubMed ID: 16621992
   
  
• Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
  Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, Sato N, Kaiser A, Hinrichs CS, Heinrichs C, Klebanoff CA, Tagaya Y, Restifo NP
  J Immunol. 2006
  PubMed ID: 16621991
   
  
• Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction.
  Hayashi RJ, Kanagawa O
  Int Immunol. 2006
  PubMed ID: 16574670
   
  
• Aggressive non-Hodgkin's lymphoma: concomitant evaluation of interleukin-2, soluble interleukin-2 receptor, interleukin-4, interleukin-6, interleukin-10 and correlation with outcome.
  Fabre-Guillevin E, Tabrizi R, Coulon V, Monnereau A, Eghbali H, Soubeyran I, Soubeyran P
  Leuk Lymphoma. 2006
  PubMed ID: 16690518
   
  
• Associations of the IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFN (gamma) R1 cytokine receptor genes with AIDS progression in a French AIDS cohort.
  Do H, Vasilescu A, Diop G, Hirtzig T, Coulonges C, Labib T, Heath SC, Spadoni JL, Therwath A, Lathrop M, Matsuda F, Zagury JF
  Immunogenetics. 2006
  PubMed ID: 16491350
   
  
• Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis.
  Guyot-Revol V, Innes JA, Hackforth S, Hinks T, Lalvani A
  Am J Respir Crit Care Med. 2006
  PubMed ID: 16339919
   
  
• Cutting Edge: Anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells.
  Kohm AP, McMahon JS, Podojil JR, Begolka WS, DeGutes M, Kasprowicz DJ, Ziegler SF, Miller SD
  J Immunol. 2006
  PubMed ID: 16517695
   
  
• A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?
  Strieder TG, Drexhage HA, Lam-Tse WK, Prummel MF, Tijssen JG, Wiersinga WM
  Autoimmunity. 2006
  PubMed ID: 16698664
   
  
• Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.
  Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16477002
   
  
• A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A
  Am J Hum Genet. 2006
  PubMed ID: 16385451
   
  
• Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
  Wang X, Rickert M, Garcia KC
  Science. 2005
  PubMed ID: 16293754
   
  
• Serum evaluation of the balance between soluble interleukin-2 and interleukin-4 receptors.
  Fujita N, Okamoto Y, Gotoh Y, Yada Y, Suzuki Y, Ando T, Togari H, Nishida M
  Cytokine. 2005
  PubMed ID: 16226465
   
  
• A function for interleukin 2 in Foxp3-expressing regulatory T cells.
  Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY
  Nat Immunol. 2005
  PubMed ID: 16227984
   
  
• Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling.
  D'Cruz LM, Klein L
  Nat Immunol. 2005
  PubMed ID: 16227983
   
  
• Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease.
  Zorn E, Kim HT, Lee SJ, Floyd BH, Litsa D, Arumugarajah S, Bellucci R, Alyea EP, Antin JH, Soiffer RJ, Ritz J
  Blood. 2005
  PubMed ID: 15972448
   
  
• A negative regulatory element-dependent inhibitory role of ITF2B on IL-2 receptor alpha gene.
  Lu Y, Sheng DQ, Mo ZC, Li HF, Wu NH, Shen YF
  Biochem Biophys Res Commun. 2005
  PubMed ID: 16126178
   
  
• Smad-dependent cooperative regulation of interleukin 2 receptor alpha chain gene expression by T cell receptor and transforming growth factor-beta.
  Kim HP, Kim BG, Letterio J, Leonard WJ
  J Biol Chem. 2005
  PubMed ID: 16087671
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Subthalamic neurons coordinate basal ganglia function through differential neural pathways.
  Yasoshima Y, Kai N, Yoshida S, Shiosaka S, Koyama Y, Kayama Y, Kobayashi K
  J Neurosci. 2005
  PubMed ID: 16120775
   
  
• IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes.
  Mekala DJ, Alli RS, Geiger TL
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16087867
   
  
• High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth.
  Rao BM, Driver I, Lauffenburger DA, Wittrup KD
  Biochemistry. 2005
  PubMed ID: 16060678
   
  
• The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis.
  Sharma R, Bagavant H, Jarjour WN, Sung SS, Ju ST
  J Immunol. 2005
  PubMed ID: 16034141
   
  
• CD25-expressing CD8+ T cells are potent memory cells in old age.
  Herndler-Brandstetter D, Schwaiger S, Veel E, Fehrer C, Cioca DP, Almanzar G, Keller M, Pfister G, Parson W, Würzner R, Schönitzer D, Henson SM, Aspinall R, Lepperdinger G, Grubeck-Loebenstein B
  J Immunol. 2005
  PubMed ID: 16034095
   
  
• Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells.
  Baan CC, van der Mast BJ, Klepper M, Mol WM, Peeters AM, Korevaar SS, Balk AH, Weimar W
  Transplantation. 2005
  PubMed ID: 16003241
   
  
• Accelerated chemically induced tumor development mediated by CD4+CD25+ regulatory T cells in wild-type hosts.
  Nishikawa H, Kato T, Tawara I, Takemitsu T, Saito K, Wang L, Ikarashi Y, Wakasugi H, Nakayama T, Taniguchi M, Kuribayashi K, Old LJ, Shiku H
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 15961541
   
  
• Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses.
  Darrasse-Jèze G, Marodon G, Salomon BL, Catala M, Klatzmann D
  Blood. 2005
  PubMed ID: 15731180
   
  
• Interleukin-2alpha receptor in membrane lipid rafts.
  Li QR, Ma J, Wang H, Li JS
  Transplant Proc. 2005
  PubMed ID: 15964425
   
  
• Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.
  Erlandsson L, Licence S, Gaspal F, Lane P, Corcoran AE, Mårtensson IL
  Eur J Immunol. 2005
  PubMed ID: 15909309
   
  
• The expression of human leukocyte antigen-DR and CD25 on circulating T cells in cutaneous lupus erythematosus and correlation with disease activity.
  Wenzel J, Henze S, Brähler S, Bieber T, Tüting T
  Exp Dermatol. 2005
  PubMed ID: 15885081
   
  
• Complementary role of CD4+CD25+ regulatory T cells and TGF-beta in oral tolerance.
  Chung Y, Lee SH, Kim DH, Kang CY
  J Leukoc Biol. 2005
  PubMed ID: 15758078
   
  
• Augmented Induction of CD4+CD25+ Treg using monoclonal antibodies to CD200R.
  Gorczynski RM, Lee L, Boudakov I
  Transplantation. 2005
  PubMed ID: 15880066
   
  
• Priming in the presence of IL-10 results in direct enhancement of CD8+ T cell primary responses and inhibition of secondary responses.
  Kang SS, Allen PM
  J Immunol. 2005
  PubMed ID: 15843536
   
  
• Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.
  Locher CP, Witt SA, Kassel R, Dowell NL, Fujimura S, Levy JA
  J Gen Virol. 2005
  PubMed ID: 15784911
   
  
• Characteristics of CD4+CD25+ regulatory T cells in the peripheral circulation of patients with head and neck cancer.
  Schaefer C, Kim GG, Albers A, Hoermann K, Myers EN, Whiteside TL
  Br J Cancer. 2005
  PubMed ID: 15714205
   
  
• Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.
  Bayer AL, Yu A, Adeegbe D, Malek TR
  J Exp Med. 2005
  PubMed ID: 15753210
   
  
• T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
  Fahlén L, Read S, Gorelik L, Hurst SD, Coffman RL, Flavell RA, Powrie F
  J Exp Med. 2005
  PubMed ID: 15753207
   
  
• Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells.
  Nishikawa H, Kato T, Tawara I, Saito K, Ikeda H, Kuribayashi K, Allen PM, Schreiber RD, Sakaguchi S, Old LJ, Shiku H
  J Exp Med. 2005
  PubMed ID: 15753203
   
  
• Displacement of SATB1-bound histone deacetylase 1 corepressor by the human immunodeficiency virus type 1 transactivator induces expression of interleukin-2 and its receptor in T cells.
  Kumar PP, Purbey PK, Ravi DS, Mitra D, Galande S
  Mol Cell Biol. 2005
  PubMed ID: 15713622
   
  
• The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.
  Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I
  J Exp Med. 2005
  PubMed ID: 15728238
   
  
• Down-regulation of myasthenogenic T cell responses by a dual altered peptide ligand via CD4+CD25+-regulated events leading to apoptosis.
  Ben-David H, Sela M, Mozes E
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 15677327
   
  
• Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cells.
  Coenen JJ, Koenen HJ, van Rijssen E, Hilbrands LB, Joosten I
  Transplantation. 2005
  PubMed ID: 15665762
   
  
• A model of the ternary complex of interleukin-10 with its soluble receptors.
  Pletnev S, Magracheva E, Wlodawer A, Zdanov A
  BMC Struct Biol. 2005
  PubMed ID: 15985167
   
  
• Stat5 tetramer formation is associated with leukemogenesis.
  Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, Bunting KD, Wagner EF, Sonneck K, Valent P, Ihle JN, Beug H
  Cancer Cell. 2005
  PubMed ID: 15652752
   
  
• Investigation of possible cytokine induction in peripheral blood mononuclear cells by heat-stable serotypes of Campylobacter jejuni.
  Chatzipanagiotou S, Michalopoulou M, Marinou I, Boufidou F, Papavasileiou E, Trikka-Graphakos E, Kabouri E, Nicolaou C, Legakis NJ
  Clin Microbiol Infect. 2005
  PubMed ID: 15649306
   
  
• Peyer's patch dendritic cells capturing oral antigen interact with antigen-specific T cells and induce gut-homing CD4(+)CD25(+) regulatory T cells in Peyer's patches.
  Nagatani K, Sagawa K, Komagata Y, Yamamoto K
  Ann N Y Acad Sci. 2004
  PubMed ID: 15681783
   
  
• BAFF binding to T cell-expressed BAFF-R costimulates T cell proliferation and alloresponses.
  Ye Q, Wang L, Wells AD, Tao R, Han R, Davidson A, Scott ML, Hancock WW
  Eur J Immunol. 2004
  PubMed ID: 15368291
   
  
• Interleukin-2 receptor antagonists and aggressive steroid minimization strategies for kidney transplant patients.
  Vincenti F
  Transpl Int. 2004
  PubMed ID: 15365604
   
  
• Soluble interleukin-2 receptor in cancer.
  Murakami S
  Front Biosci. 2004
  PubMed ID: 15353339
   
  
• Degree of CD25 expression in T-cell lymphoma is dependent on tissue site: implications for targeted therapy.
  Jones D, Ibrahim S, Patel K, Luthra R, Duvic M, Medeiros LJ
  Clin Cancer Res. 2004
  PubMed ID: 15328201
   
  
• STAT5 is required for thymopoiesis in a development stage-specific manner.
  Kang J, DiBenedetto B, Narayan K, Zhao H, Der SD, Chambers CA
  J Immunol. 2004
  PubMed ID: 15294943
   
  
• IL-2 and IL-15 receptor alpha-subunits are coexpressed in a supramolecular receptor cluster in lipid rafts of T cells.
  Vámosi G, Bodnár A, Vereb G, Jenei A, Goldman CK, Langowski J, Tóth K, Mátyus L, Szöllösi J, Waldmann TA, Damjanovich S
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15263076
   
  
• CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development.
  McKee AS, Pearce EJ
  J Immunol. 2004
  PubMed ID: 15240714
   
  
• Can IL-2R alpha be a valuable marker along with CA 19-9 in the diagnosis of chronic pancreatitis and pancreatic cancer?
  Kayhan B, Kayhan B, Akdoğan M
  Int J Biol Markers. 2004
  PubMed ID: 15503821
   
  
• Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy.
  Karlsson MR, Rugtveit J, Brandtzaeg P
  J Exp Med. 2004
  PubMed ID: 15197226
   
  
• The DNA sequence and comparative analysis of human chromosome 10.
  Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J
  Nature. 2004
  PubMed ID: 15164054
   
  
• Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
  Bensinger SJ, Walsh PT, Zhang J, Carroll M, Parsons R, Rathmell JC, Thompson CB, Burchill MA, Farrar MA, Turka LA
  J Immunol. 2004
  PubMed ID: 15100267
   
  
• CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors.
  Madakamutil LT, Christen U, Lena CJ, Wang-Zhu Y, Attinger A, Sundarrajan M, Ellmeier W, von Herrath MG, Jensen P, Littman DR, Cheroutre H
  Science. 2004
  PubMed ID: 15105501
   
  
• High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
  Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
  Genome Res. 2004
  PubMed ID: 15060019
   
  
• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
  Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
  Nature. 2004
  PubMed ID: 15057822
   
  
• IL-2, regulatory T cells, and tolerance.
  Nelson BH
  J Immunol. 2004
  PubMed ID: 15034008
   
  
• Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.
  Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 14990792
   
  
• STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
  O'Sullivan A, Chang HC, Yu Q, Kaplan MH
  J Biol Chem. 2004
  PubMed ID: 14660657
   
  
• Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease.
  Nishibori T, Tanabe Y, Su L, David M
  J Exp Med. 2004
  PubMed ID: 14699080
   
  
• Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study.
  García-Tuñón I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M
  Breast Cancer Res. 2004
  PubMed ID: 14680494
   
  
• IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
  D'Souza WN, Lefrançois L
  J Immunol. 2003
  PubMed ID: 14634080
   
  
• Genetic loci that control vascular endothelial growth factor-induced angiogenesis.
  Rogers MS, Rohan RM, Birsner AE, D'Amato RJ
  FASEB J. 2003
  PubMed ID: 12958152
   
  
• Detection of T lymphocyte subsets and mIL-2R on surface of PBMC in patients with hepatitis B.
  Wang KX, Peng JL, Wang XF, Tian Y, Wang J, Li CP
  World J Gastroenterol. 2003
  PubMed ID: 12970897
   
  
• Fas is not essential for lamina propria T lymphocyte homeostasis.
  Boone DL, Dassopoulos T, Chai S, Chien M, Lodolce J, Ma A
  Am J Physiol Gastrointest Liver Physiol. 2003
  PubMed ID: 12702495
   
  
• Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation.
  Egawa T, Albrecht B, Favier B, Sunshine MJ, Mirchandani K, O'Brien W, Thome M, Littman DR
  Curr Biol. 2003
  PubMed ID: 12867038
   
  
• Role of prolactin receptor and CD25 in protection of circulating T lymphocytes from apoptosis in patients with breast cancer.
  Bauernhofer T, Kuss I, Friebe-Hoffmann U, Baum AS, Dworacki G, Vonderhaar BK, Whiteside TL
  Br J Cancer. 2003
  PubMed ID: 12698200
   
  
• Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.
  Lindemann MJ, Benczik M, Gaffen SL
  J Biol Chem. 2003
  PubMed ID: 12525482
   
  
• CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism.
  Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL
  J Immunol. 2003
  PubMed ID: 12594277
   
  
• Serum soluble interleukin-2 receptor in eosinophilia.
  Kaito K, Otsubo H, Ogasawara Y, Kimura H, Kurihara E, Koike M, Aiso M, Kobayashi M
  Acta Haematol. 2003
  PubMed ID: 12486319
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Tumour necrosis factor-alpha, interleukin-2 soluble receptor and different inflammatory parameters in patients with rheumatoid arthritis.
  Fröde TS, Tenconi P, Debiasi MR, Medeiros YS
  Mediators Inflamm. 2002
  PubMed ID: 12581498
   
  
• Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
  Almeida AR, Legrand N, Papiernik M, Freitas AA
  J Immunol. 2002
  PubMed ID: 12391195
   
  
• SATB1 targets chromatin remodelling to regulate genes over long distances.
  Yasui D, Miyano M, Cai S, Varga-Weisz P, Kohwi-Shigematsu T
  Nature. 2002
  PubMed ID: 12374985
   
  
• An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines.
  Hwang ES, White IA, Ho IC
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12271139
   
  
• Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus.
  Klug DB, Carter C, Gimenez-Conti IB, Richie ER
  J Immunol. 2002
  PubMed ID: 12218095
   
  
• Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells.
  Sereti I, Martinez-Wilson H, Metcalf JA, Baseler MW, Hallahan CW, Hahn B, Hengel RL, Davey RT, Kovacs JA, Lane HC
  Blood. 2002
  PubMed ID: 12200381
   
  
• Expression of IL-2alpha and IL-2beta receptors on the membrane surface of human sperm.
  Fierro R, Schwed P, Foliguet B, Grignon G, Bene MC, Faure G
  Arch Androl. 2002
  PubMed ID: 12230826
   
  
• Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice.
  Kirstein SL, Davidson KL, Ehringer MA, Sikela JM, Erwin VG, Tabakoff B
  J Pharmacol Exp Ther. 2002
  PubMed ID: 12183685
   
  
• Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites.
  Imbert V, Rezzonico R, Reichenbach P, Nabholz M
  Eur Cytokine Netw. 2002
  PubMed ID: 12231477
   
  
• The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements.
  Kim HP, Leonard WJ
  EMBO J. 2002
  PubMed ID: 12065418
   
  
• Cellular immune responses to recombinant antigens in pregnant women chronically infected with Toxoplasma gondii.
  Fatoohi AF, Cozon GJ, Greenland T, Ferrandiz J, Bienvenu J, Picot S, Peyron F
  Clin Diagn Lab Immunol. 2002
  PubMed ID: 11986281
   
  
• Control of IL-2Ralpha gene expression: structural changes within the proximal enhancer/core promoter during T-cell development.
  Yeh JH, Spicuglia S, Kumar S, Sanchez-Sevilla A, Ferrier P, Imbert J
  Nucleic Acids Res. 2002
  PubMed ID: 11972331
   
  
• Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene.
  Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B
  Nat Immunol. 2002
  PubMed ID: 11927910
   
  
• Thymopoiesis requires Pax9 function in thymic epithelial cells.
  Hetzer-Egger C, Schorpp M, Haas-Assenbaum A, Balling R, Peters H, Boehm T
  Eur J Immunol. 2002
  PubMed ID: 11932925
   
  
• Similarity between eruptions induced by sulfhydryl drugs and acute cutaneous graft-versus-host disease after bone marrow transplantation.
  Takatsuka H, Takemoto Y, Yamada S, Mori A, Wada H, Fujimori Y, Okamoto T, Kanamaru A, Kakishita E
  Hematology. 2002
  PubMed ID: 12171778
   
  
• GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines.
  Matkó J, Bodnár A, Vereb G, Bene L, Vámosi G, Szentesi G, Szöllösi J, Gáspár R, Horejsi V, Waldmann TA, Damjanovich S
  Eur J Biochem. 2002
  PubMed ID: 11856346
   
  
• Natural CD4 CD25(+) regulatory T cells control the burst of superantigen-induced cytokine production: the role of IL-10.
  Pontoux C, Banz A, Papiernik M
  Int Immunol. 2002
  PubMed ID: 11809742
   
  
• Oligomerization of IL-2Ralpha.
  Eicher DM, Damjanovich S, Waldmann TA
  Cytokine. 2002
  PubMed ID: 11886175
   
  
• Cytokine release by activated T-cells in large granular lymphocytic leukemia associated with autoimmune disorders.
  Shvidel L, Duksin C, Tzimanis A, Shtalrid M, Klepfish A, Sigler E, Haran M, Eilat E, Berrebi A
  Hematol J. 2002
  PubMed ID: 11960393
   
  
• The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.
  Kim HP, Kelly J, Leonard WJ
  Immunity. 2001
  PubMed ID: 11485747
   
  
• Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor alpha-chain locus.
  Yeh JH, Lecine P, Nunes JA, Spicuglia S, Ferrier P, Olive D, Imbert J
  Mol Cell Biol. 2001
  PubMed ID: 11416131
   
  
• Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization.
  Wang L, Yan L, McGuire C, Kozak CA, Wang M, Kim UJ, Siciliano M, Weinshilboum RM
  Inflamm Res. 2001
  PubMed ID: 11475331
   
  
• Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance.
  Keller RS, Shai SY, Babbitt CJ, Pham CG, Solaro RJ, Valencik ML, Loftus JC, Ross RS
  Am J Pathol. 2001
  PubMed ID: 11238056
   
  
• The sequence of the human genome.
  Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigó R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X
  Science. 2001
  PubMed ID: 11181995
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Binding of HMG-I(Y) imparts architectural specificity to a positioned nucleosome on the promoter of the human interleukin-2 receptor alpha gene.
  Reeves R, Leonard WJ, Nissen MS
  Mol Cell Biol. 2000
  PubMed ID: 10848593
   
  
• Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
  Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ
  Mol Cell Biol. 2000
  PubMed ID: 10825200
   
  
• The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.
  Lin JX, Leonard WJ
  Oncogene. 2000
  PubMed ID: 10851055
   
  
• Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis.
  Poussier P, Ning T, Chen J, Banerjee D, Julius M
  Gastroenterology. 2000
  PubMed ID: 10784587
   
  
• IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells.
  Rameil P, Lécine P, Ghysdael J, Gouilleux F, Kahn-Perlès B, Imbert J
  Oncogene. 2000
  PubMed ID: 10815800
   
  
• Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements.
  Maki K, Nagata K, Kitamura F, Takemori T, Karasuyama H
  J Exp Med. 2000
  PubMed ID: 10770800
   
  
• Chromosomal mapping of osteopenia-associated quantitative trait loci using closely related mouse strains.
  Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis RJ
  J Bone Miner Res. 2000
  PubMed ID: 10780854
   
  
• Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand.
  Mages HW, Hutloff A, Heuck C, Büchner K, Himmelbauer H, Oliveri F, Kroczek RA
  Eur J Immunol. 2000
  PubMed ID: 10760791
   
  
• Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
  Delespine-Carmagnat M, Bouvier G, Bertoglio J
  Eur J Immunol. 2000
  PubMed ID: 10602027
   
  
• Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.
  Matsumoto M
  J Med Invest. 1999
  PubMed ID: 10687308
   
  
• CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation.
  Sepulveda H, Cerwenka A, Morgan T, Dutton RW
  J Immunol. 1999
  PubMed ID: 10415007
   
  
• Immunosuppression for neural xenografts: a comparison of cyclosporin and anti-CD25 monoclonal antibody.
  Honey CR, Shen H
  J Neurosurg. 1999
  PubMed ID: 10389888
   
  
• The absence of IL-6 does not affect Th2 cell development in vivo, but does lead to impaired proliferation, IL-2 receptor expression, and B cell responses.
  La Flamme AC, Pearce EJ
  J Immunol. 1999
  PubMed ID: 10229817
   
  
• Genetic mapping of eight SH3 domain genes on seven mouse chromosomes.
  Lee CG, Morse HC, Kay BK, Kozak CA
  Mamm Genome. 1999
  PubMed ID: 10087302
   
  
• Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines.
  Imbert V, Renauld PR
  Eur Cytokine Netw. 1999
  PubMed ID: 10210776
   
  
• Multiple gamma c-dependent cytokines regulate T-cell development.
  Malek TR, Porter BO, He YW
  Immunol Today. 1999
  PubMed ID: 10098325
   
  
• Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
  Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN
  Immunity. 1999
  PubMed ID: 10072077
   
  
• The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model.
  Girgis L, Davis MM, Fazekas de St Groth B
  J Exp Med. 1999
  PubMed ID: 9892609
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination.
  Watanabe D, Inokawa H, Hashimoto K, Suzuki N, Kano M, Shigemoto R, Hirano T, Toyama K, Kaneko S, Yokoi M, Moriyoshi K, Suzuki M, Kobayashi K, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S
  Cell. 1998
  PubMed ID: 9778244
   
  
• Free interleukin-2 receptors in children with trisomy 21 (Down's syndrome) and different levels of periodontal disease.
  Cutando-Soriano A, Gómez-Moreno G, Bravo M
  Int J Paediatr Dent. 1998
  PubMed ID: 17294624
   
  
• Cutting edge: JAK3 activation and rescue of T cells from HIV gp120-induced unresponsiveness.
  Selliah N, Finkel TH
  J Immunol. 1998
  PubMed ID: 9637477
   
  
• Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.
  Kung JT, Beller D, Ju ST
  Cell Immunol. 1998
  PubMed ID: 9636694
   
  
• Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.
  Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Pénit C
  Int Immunol. 1998
  PubMed ID: 9620592
   
  
• Does the IL-2 receptor alpha chain induced on dendritic cells have a biological function?
  Kronin V, Vremec D, Shortman K
  Int Immunol. 1998
  PubMed ID: 9533452
   
  
• T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death.
  Zheng L, Trageser CL, Willerford DM, Lenardo MJ
  J Immunol. 1998
  PubMed ID: 9551911
   
  
• Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription.
  Meyer WK, Reichenbach P, Schindler U, Soldaini E, Nabholz M
  J Biol Chem. 1997
  PubMed ID: 9395528
   
  
• Mouse brain microglia express interleukin-15 and its multimeric receptor complex functionally coupled to Janus kinase activity.
  Hanisch UK, Lyons SA, Prinz M, Nolte C, Weber JR, Kettenmann H, Kirchhoff F
  J Biol Chem. 1997
  PubMed ID: 9360952
   
  
• Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
  Gene. 1997
  PubMed ID: 9373149
   
  
• Role of IL-2 in rat fetal thymocyte development.
  Varas A, Vicente A, Romo T, Zapata AG
  Int Immunol. 1997
  PubMed ID: 9352365
   
  
• Interleukin-2 receptor beta and gamma chain dysregulation during the inhibition of CD4 T cell activation by human immunodeficiency virus-1 gp120.
  Bani L, David D, Février M, Pialoux G, Dupont B, Sugamura K, Thèze J
  Eur J Immunol. 1997
  PubMed ID: 9341758
   
  
• Characterization of definitive lymphohematopoietic stem cells in the day 9 murine yolk sac.
  Yoder MC, Hiatt K, Dutt P, Mukherjee P, Bodine DM, Orlic D
  Immunity. 1997
  PubMed ID: 9324354
   
  
• [Relationship between human cytomegalovirus infection and soluble interleukin-2 receptor level]
  Cao Y, Li A
  Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997
  PubMed ID: 15617342
   
  
• Temporal and subunit-specific modulations of the Rel/NF-kappaB transcription factors through CD28 costimulation.
  Kahn-Perlès B, Lipcey C, Lécine P, Olive D, Imbert J
  J Biol Chem. 1997
  PubMed ID: 9268307
   
  
• Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.
  Li CJ, Ueda Y, Shi B, Borodyansky L, Huang L, Li YZ, Pardee AB
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9223324
   
  
• Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism.
  Horiuchi S, Koyanagi Y, Tanaka Y, Waki M, Matsumoto A, Zhou YW, Yamamoto M, Yamamoto N
  Immunology. 1997
  PubMed ID: 9203962
   
  
• Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.
  Van Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK
  J Immunol. 1997
  PubMed ID: 9103438
   
  
• Elf-1 contributes to the function of the complex interleukin (IL)-2-responsive enhancer in the mouse IL-2 receptor alpha gene.
  Serdobova I, Pla M, Reichenbach P, Sperisen P, Ghysdael J, Wilson A, Freeman J, Nabholz M
  J Exp Med. 1997
  PubMed ID: 9104808
   
  
• Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor.
  Sharfe N, Dadi HK, Shahar M, Roifman CM
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9096364
   
  
• [Study on relationship of soluble interleukin-2 receptors in serious hepatitis B patients and the T lymphocyte subgroup]
  Zhang P, Wei F, Jiao W, Yang Y
  Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997
  PubMed ID: 15619904
   
  
• Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene.
  Lécine P, Algarté M, Rameil P, Beadling C, Bucher P, Nabholz M, Imbert J
  Mol Cell Biol. 1996
  PubMed ID: 8943338
   
  
• An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
  John S, Robbins CM, Leonard WJ
  EMBO J. 1996
  PubMed ID: 8896456
   
  
• Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice.
  Hazenbos WL, Gessner JE, Hofhuis FM, Kuipers H, Meyer D, Heijnen IA, Schmidt RE, Sandor M, Capel PJ, Daëron M, van de Winkel JG, Verbeek JS
  Immunity. 1996
  PubMed ID: 8769481
   
  
• Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.
  Bouvier G, Watrin F, Naspetti M, Verthuy C, Naquet P, Ferrier P
  Proc Natl Acad Sci U S A. 1996
  PubMed ID: 8755570
   
  
• Human fibroblasts express functional IL-2 receptors formed by the IL-2R alpha- and beta-chain subunits: association of IL-2 binding with secretion of the monocyte chemoattractant protein-1.
  Gruss HJ, Scott C, Rollins BJ, Brach MA, Herrmann F
  J Immunol. 1996
  PubMed ID: 8752938
   
  
• Nitrous oxide antinociception in BXD recombinant inbred mouse strains and identification of quantitative trait loci.
  Quock RM, Mueller JL, Vaughn LK, Belknap JK
  Brain Res. 1996
  PubMed ID: 8828582
   
  
• Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development.
  Reya T, Yang-Snyder JA, Rothenberg EV, Carding SR
  Blood. 1996
  PubMed ID: 8547641
   
  
• Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes.
  Anderson DM, Kumaki S, Ahdieh M, Bertles J, Tometsko M, Loomis A, Giri J, Copeland NG, Gilbert DJ, Jenkins NA
  J Biol Chem. 1995
  PubMed ID: 8530383
   
  
• Prolactin and interleukin-2 receptors in T lymphocytes signal through a MGF-STAT5-like transcription factor.
  Gouilleux F, Moritz D, Humar M, Moriggl R, Berchtold S, Groner B
  Endocrinology. 1995
  PubMed ID: 7588326
   
  
• Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk.
  Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL
  Nature. 1995
  PubMed ID: 7477352
   
  
• Genetic mapping of the interleukin 1 receptor alpha and beta chain genes in the mouse.
  Kozak CA, Leonard WJ
  Mamm Genome. 1995
  PubMed ID: 8597644
   
  
• Influence of thyroxine and thyroxine with growth hormone and prolactin on splenocyte subsets and on the expression of interleukin-2 and prolactin receptors on splenocyte subsets of Snell dwarf mice.
  Gala RR
  Proc Soc Exp Biol Med. 1995
  PubMed ID: 7568281
   
  
• Differences in the interleukin-2 (IL-2) receptor system in human and mouse: alpha chain is required for formation of the functional mouse IL-2 receptor.
  Nemoto T, Takeshita T, Ishii N, Kondo M, Higuchi M, Satomi S, Nakamura M, Mori S, Sugamura K
  Eur J Immunol. 1995
  PubMed ID: 7489734
   
  
• In vivo regulation of interleukin-2 receptor alpha gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells.
  Algarté M, Lécine P, Costello R, Plet A, Olive D, Imbert J
  EMBO J. 1995
  PubMed ID: 7588634
   
  
• Cloning and chromosomal assignment of the bovine interleukin-2 receptor alpha (IL-2R alpha) gene.
  Yoo J, Ponce de Leon FA, Stone RT, Beattie CW
  Mamm Genome. 1995
  PubMed ID: 8563178
   
  
• Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.
  Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW
  Immunity. 1995
  PubMed ID: 7584142
   
  
• Molecular cloning of IL-2R alpha, IL-2R beta, and IL-2R gamma cDNAs from a human oligodendroglioma cell line: presence of IL-2R mRNAs in the human central nervous system.
  Otero GC, Merrill JE
  Glia. 1995
  PubMed ID: 8530186
   
  
• Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.
  Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM
  EMBO J. 1995
  PubMed ID: 7641685
   
  
• Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.
  Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M
  J Immunol. 1995
  PubMed ID: 7636184
   
  
• Analysis of interleukin receptor gene expression in mouse fetal liver by quantitative polymerase chain reaction.
  Jia GQ, Gutierrez-Ramos JC
  Eur J Immunol. 1995
  PubMed ID: 7621883
   
  
• Molecular cloning of the coding sequence of an interleukin-2 receptor alpha subunit cDNA in murine brain.
  Petitto JM, Huang Z
  J Neuroimmunol. 1995
  PubMed ID: 7797614
   
  
• Mouse interleukin-2 receptor alpha gene expression. Interleukin-1 and interleukin-2 control transcription via distinct cis-acting elements.
  Sperisen P, Wang SM, Soldaini E, Pla M, Rusterholz C, Bucher P, Corthésy P, Reichenbach P, Nabholz M
  J Biol Chem. 1995
  PubMed ID: 7738013
   
  
• Mouse interleukin-2 receptor alpha gene expression. Delimitation of cis-acting regulatory elements in transgenic mice and by mapping of DNase-I hypersensitive sites.
  Soldaini E, Pla M, Beermann F, Espel E, Corthésy P, Barangé S, Waanders GA, MacDonald HR, Nabholz M
  J Biol Chem. 1995
  PubMed ID: 7738012
   
  
• Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.
  Dianzani U, Bragardo M, Buonfiglio D, Redoglia V, Funaro A, Portoles P, Rojo J, Malavasi F, Pileri A
  Eur J Immunol. 1995
  PubMed ID: 7539755
   
  
• Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.
  Miyazaki T, Liu ZJ, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Permutter RM, Taniguchi T
  Cell. 1995
  PubMed ID: 7736574
   
  
• Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.
  Pekny M, Levéen P, Pekna M, Eliasson C, Berthold CH, Westermark B, Betsholtz C
  EMBO J. 1995
  PubMed ID: 7737111
   
  
• Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.
  John S, Reeves RB, Lin JX, Child R, Leiden JM, Thompson CB, Leonard WJ
  Mol Cell Biol. 1995
  PubMed ID: 7862168
   
  
• Human immunodeficiency virus type 1 Nef protein inhibits activation pathways in peripheral blood mononuclear cells and T-cell lines.
  Greenway A, Azad A, McPhee D
  J Virol. 1995
  PubMed ID: 7853525
   
  
• Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line.
  Puri RK, Leland P, Aggarwal BB
  AIDS Res Hum Retroviruses. 1995
  PubMed ID: 7734194
   
  
• Human chromosome 10 loci map to three different sheep chromosomes.
  Ansari HA, Pearce PD, Maher DW, Broad TE
  Mamm Genome. 1995
  PubMed ID: 7719026
   
  
• The interleukin-2 and interleukin-4 receptors studied by molecular modelling.
  Bamborough P, Hedgecock CJ, Richards WG
  Structure. 1994
  PubMed ID: 7529123
   
  
• IL-2 receptor alpha chain expression during early B lymphocyte differentiation.
  Chen J, Ma A, Young F, Alt FW
  Int Immunol. 1994
  PubMed ID: 7981152
   
  
• IL-2 receptor alpha chain (CD25, TAC) expression defines a crucial stage in pre-B cell development.
  Rolink A, Grawunder U, Winkler TH, Karasuyama H, Melchers F
  Int Immunol. 1994
  PubMed ID: 7526894
   
  
• Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone.
  Yanagida T, Kato T, Igarashi O, Inoue T, Nariuchi H
  J Immunol. 1994
  PubMed ID: 7909827
   
  
• Heat-stable antigen/CD24 on mouse T lymphocytes: evidence for a costimulatory function.
  Hubbe M, Altevogt P
  Eur J Immunol. 1994
  PubMed ID: 8125140
   
  
• Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
  Maruyama K, Sugano S
  Gene. 1994
  PubMed ID: 8125298
   
  
• Nef 27, but not the Nef 25 isoform of human immunodeficiency virus-type 1 pNL4.3 down-regulates surface CD4 and IL-2R expression in peripheral blood mononuclear cells and transformed T cells.
  Greenway AL, McPhee DA, Grgacic E, Hewish D, Lucantoni A, Macreadie I, Azad A
  Virology. 1994
  PubMed ID: 7903128
   
  
• Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.
  Zurawski SM, Vega F, Doyle EL, Huyghe B, Flaherty K, McKay DB, Zurawski G
  EMBO J. 1993
  PubMed ID: 8262055
   
  
• Differential T cell costimulatory requirements in CD28-deficient mice.
  Shahinian A, Pfeffer K, Lee KP, Kündig TM, Kishihara K, Wakeham A, Kawai K, Ohashi PS, Thompson CB, Mak TW
  Science. 1993
  PubMed ID: 7688139
   
  
• The state of DNA methylation in the promoter and exon 1 regions of the human gene for the interleukin-2 receptor alpha chain (IL-2R alpha) in various cell types.
  Behn-Krappa A, Doerfler W
  Hum Mol Genet. 1993
  PubMed ID: 8364583
   
  
• Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
  Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
  Science. 1993
  PubMed ID: 8493579
   
  
• Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.
  Costello R, Lipcey C, Algarté M, Cerdan C, Baeuerle PA, Olive D, Imbert J
  Cell Growth Differ. 1993
  PubMed ID: 8098618
   
  
• The hematopoietin receptor superfamily.
  Cosman D
  Cytokine. 1993
  PubMed ID: 8392875
   
  
• Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells.
  Morse HC
  J Immunol. 1992
  PubMed ID: 1431091
   
  
• A new cDNA sequence for the murine interleukin-2 gene.
  Matesanz F, Alcina A, Pellicer A
  Biochim Biophys Acta. 1992
  PubMed ID: 1420317
   
  
• Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein.
  Purvis SF, Georges DL, Williams TM, Lederman MM
  Cell Immunol. 1992
  PubMed ID: 1394441
   
  
• Transient expression of the IL-2 receptor alpha-chain in IL-6-induced myeloid cells is regulated by autocrine production of prostaglandin E2.
  Ruhl S, Begley CG, Bickel M, Pluznik DH
  Exp Hematol. 1992
  PubMed ID: 1587308
   
  
• Induction of IL-2 receptor expression and proliferation of T cell clones by a novel cytokine(s).
  Kato T, Inoue T, Yamamoto K, Tamura T, Nariuchi H
  Cell Immunol. 1992
  PubMed ID: 1586961
   
  
• The augmentation of lymphokine-activated killer activity following pulsing of human peripheral blood mononuclear cells with recombinant human interleukin-2.
  Carter CR, Hancock BW, Rees RC
  Cancer Immunol Immunother. 1992
  PubMed ID: 1511461
   
  
• A novel subpopulation of CD45RA+ CD4+ T cells expressing IL-2 receptor alpha-chain (CD25) and having a functionally transitional nature into memory cells.
  Kanegane H, Miyawaki T, Kato K, Yokoi T, Uehara T, Yachie A, Taniguchi N
  Int Immunol. 1991
  PubMed ID: 1685671
   
  
• A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx.
  Ruegg CL, Strand M
  Cell Immunol. 1991
  PubMed ID: 1832084
   
  
• Molecular cloning of cDNAs for the rat interleukin 2 receptor alpha and beta chain genes: differentially regulated gene activity in response to mitogenic stimulation.
  Page TH, Dallman MJ
  Eur J Immunol. 1991
  PubMed ID: 1889461
   
  
• The interleukin-2 receptor.
  Waldmann TA
  J Biol Chem. 1991
  PubMed ID: 1993646
   
  
• Expression of IL-2 receptor p55 and p75 chains by human B lymphocytes: effects of activation and differentiation.
  Zola H, Weedon H, Thompson GR, Fung MC, Ingley E, Hapel AJ
  Immunology. 1991
  PubMed ID: 2016116
   
  
• Mapping HSA10 homologous loci in cattle.
  Threadgill DS, Womack JE
  Cytogenet Cell Genet. 1991
  PubMed ID: 1655359
   
  
• Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor.
  Burton J, Goldman CK, Rao P, Moos M, Waldmann TA
  Proc Natl Acad Sci U S A. 1990
  PubMed ID: 1976256
   
  
• Sp1 represses IL-2 receptor alpha chain gene expression.
  Roman DG, Toledano MB, Leonard WJ
  New Biol. 1990
  PubMed ID: 2083254
   
  
• Interleukin-2 and the IL-2 receptor: new insights into structure and function.
  Kuziel WA, Greene WC
  J Invest Dermatol. 1990
  PubMed ID: 1693645
   
  
• Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.
  Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S
  Proc Natl Acad Sci U S A. 1990
  PubMed ID: 2315327
   
  
• The same target sequences are differentially important for activation of the interleukin 2 receptor alpha-chain gene in two distinct T-cell lines.
  Toledano MB, Roman DG, Halden NF, Lin BB, Leonard WJ
  Proc Natl Acad Sci U S A. 1990
  PubMed ID: 2308942
   
  
• Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated.
  Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC
  J Biol Chem. 1990
  PubMed ID: 2303462
   
  
• Delineation of an enhancerlike positive regulatory element in the interleukin-2 receptor alpha-chain gene.
  Lin BB, Cross SL, Halden NF, Roman DG, Toledano MB, Leonard WJ
  Mol Cell Biol. 1990
  PubMed ID: 2153927
   
  
• Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2.
  Webb GC, Campbell HD, Lee JS, Young IG
  Cytogenet Cell Genet. 1990
  PubMed ID: 2265562
   
  
• IL-2 protects T cell hybrids from the cytolytic effect of glucocorticoids. Synergistic effect of IL-2 and dexamethasone in the induction of high-affinity IL-2 receptors.
  Fernández-Ruiz E, Rebollo A, Nieto MA, Sanz E, Somoza C, Ramirez F, Lopez-Rivas A, Silva A
  J Immunol. 1989
  PubMed ID: 2592769
   
  
• Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's.
  Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T
  Science. 1989
  PubMed ID: 2785715
   
  
• Functionally distinct NF-kappa B binding sites in the immunoglobulin kappa and IL-2 receptor alpha chain genes.
  Cross SL, Halden NF, Lenardo MJ, Leonard WJ
  Science. 1989
  PubMed ID: 2497520
   
  
• Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.
  Tsudo M, Kitamura F, Miyasaka M
  Proc Natl Acad Sci U S A. 1989
  PubMed ID: 2467293
   
  
• Lymphocyte activation by HIV-1 envelope glycoprotein.
  Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM
  Nature. 1988
  PubMed ID: 2843775
   
  
• A BglI polymorphism for the interleukin-2 receptor gene (IL2R) on chromosome 10.
  Ardinger RH, Murray JC
  Nucleic Acids Res. 1988
  PubMed ID: 2901720
   
  
• p55 IL-2 receptor mRNA precursors in murine T lymphocyte nuclei.
  Froussard P, Chastagner P, Sommé G, Abadie A, Greene W, Thèze J, Longacre S
  J Immunol. 1988
  PubMed ID: 3135330
   
  
• Stimulation of the beta-subunit of the IL-2 receptor induces MHC-unrestricted cytotoxicity in T acute lymphoblastic leukemia cells and normal thymocytes.
  Colamonici OR, Rosolen A, Cole D, Kirsch I, Felix C, Poplack DG, Neckers LM
  J Immunol. 1988
  PubMed ID: 3135323
   
  
• Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure.
  Miedel MC, Hulmes JD, Weber DV, Bailon P, Pan YC
  Biochem Biophys Res Commun. 1988
  PubMed ID: 3134887
   
  
• Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.
  Cross SL, Feinberg MB, Wolf JB, Holbrook NJ, Wong-Staal F, Leonard WJ
  Cell. 1987
  PubMed ID: 3030566
   
  
• High level stable expression of human interleukin-2 receptors in mouse cells generates only low affinity interleukin-2 binding sites.
  Cosman D, Wignall J, Lewis A, Alpert A, Cerretti DP, Park L, Dower SK, Gillis S, Urdal DL
  Mol Immunol. 1986
  PubMed ID: 3097520
   
  
• Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.
  Shackelford DA, Trowbridge IS
  J Biol Chem. 1986
  PubMed ID: 2941417
   
  
• Interleukin 2 receptor expression in unstimulated murine splenic T cells. Localization to L3T4+ cells and regulation by non-H-2-linked genes.
  Kawamura H, Sharrow SO, Alling DW, Stephany D, York-Jolley J, Berzofsky JA
  J Exp Med. 1986
  PubMed ID: 3086480
   
  
• Interleukin-2 receptor: structure, function, and expression.
  Kanamori H, Kondo S, Kinoshita M, Suzuki N, Saito Y, Sabe H, Matsunami N, Ishida N, Shimizu A, Honjo T
  Cold Spring Harb Symp Quant Biol. 1986
  PubMed ID: 3107885
   
  
• Molecular cloning and structure of the human interleukin 2 receptor gene.
  Ishida N, Kanamori H, Noma T, Nikaido T, Sabe H, Suzuki N, Shimizu A, Honjo T
  Nucleic Acids Res. 1985
  PubMed ID: 2999698
   
  
• Structure of the human interleukin-2 receptor gene.
  Leonard WJ, Depper JM, Kanehisa M, Krönke M, Peffer NJ, Svetlik PB, Sullivan M, Greene WC
  Science. 1985
  PubMed ID: 2996141
   
  
• Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
  Leonard WJ, Donlon TA, Lebo RV, Greene WC
  Science. 1985
  PubMed ID: 3925551
   
  
• Nucleotide sequence and expression of a mouse interleukin 2 receptor cDNA.
  Miller J, Malek TR, Leonard WJ, Greene WC, Shevach EM, Germain RN
  J Immunol. 1985
  PubMed ID: 3921620
   
  
• Immunoelectron-microscopic localization of Tac antigen in adult T-cell leukemia/lymphoma.
  Shamoto M, Suchi T, Uchiyama T
  Am J Pathol. 1985
  PubMed ID: 2990220
   
  
• Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence.
  Shimuzu A, Kondo S, Takeda S, Yodoi J, Ishida N, Sabe H, Osawa H, Diamantstein T, Nikaido T, Honjo T
  Nucleic Acids Res. 1985
  PubMed ID: 2987826
   
  
• Interleukin 2 regulates its own receptors.
  Smith KA, Cantrell DA
  Proc Natl Acad Sci U S A. 1985
  PubMed ID: 2983318
   
  
• Cloning, sequence and expression of human interleukin-2 receptor.
  Cosman D, Cerretti DP, Larsen A, Park L, March C, Dower S, Gillis S, Urdal D
  Nature. 1984
  PubMed ID: 6096720
   
  
• Molecular cloning of cDNA encoding human interleukin-2 receptor.
  Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T
  Nature. 1984
  PubMed ID: 6090949
   
  
• Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
  Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Krönke M, Svetlik PB, Peffer NJ, Waldmann TA
  Nature. 1984
  PubMed ID: 6090948
   
  
• The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.
  Ortega G, Robb RJ, Shevach EM, Malek TR
  J Immunol. 1984
  PubMed ID: 6206144
   
  

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