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IL2

Gene Description:   interleukin 2 Synonyms:   lymphokine, TCGF, IL-2, Il-2, IL2, Il2 Orthologs:   Human IL2 (protein-coding), Mouse Il2 (protein-coding), Rat Il2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
4q27	Human	chr4:122909415..123614282	0.70	24	rs2069763 rs4505848

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd3	Mouse	chr3:36626676..37277405	0.65	9	19 no lod score

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 4q27 Orthologous Region	Rat	chr2:123220077..123823432	0.60	4
Human 4q27 Orthologous Region	Mouse	chr3:36628818..37183472	0.55	4

(Human) GRCh37 - chr4:123372625..123377880 (5.25 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr3:37019445..37024881 (5.44 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr2:123655005..123659709 (4.70 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for IL2: The IL2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs IL2   DGKA   BioGRID  empirical  8626603  IL2   IFNA1   HPRD  empirical  3262520  IL2   IL2   HPRD  empirical  12582206  IL2   IL2RA   HPRD, Reactome  empirical  1993646  16477002  1526987  8700888  IL2   IL2RB   HPRD, Reactome  empirical  11035066  8049354  8700888  IL2   IL2RG   HPRD, IntAct  empirical  10662798  8049354  8266076  IL2   FOXK2   HPRD  empirical  9065434  IL2   JAK1   Reactome  predicted  8700888  IL2   NGFR   HPRD  empirical  1316918  IL2   IL21R   BioGRID  empirical  11418623  IL2   SHC1   HPRD  empirical  10662798  IL2   CD53   HPRD  empirical  7963560

View all

KEGG Network: 10   Allograft rejection Human - 5330 Mouse - 5330 Rat - 5330 Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Chagas disease (American trypanosomiasis) Human - 5142 Mouse - 5142 Rat - 5142 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Graft-versus-host disease Human - 5332 Mouse - 5332 Rat - 5332 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Measles Human - 5162 Mouse - 5162 Rat - 5162 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940

Biocarta: 12   Antigen Dependent B Cell Activation Human Mouse Cytokine Network Human Mouse Cytokines and Inflammatory Response Human Mouse IL 18 Signaling Pathway Human Mouse IL 2 signaling pathway Human Mouse OX40 Signaling Pathway Human Mouse Regulation of hematopoiesis by cytokines Human Mouse Role of Tob in T-cell activation Human Mouse Selective expression of chemokine receptors during T-cell polarization Human Mouse Th1/Th2 Differentiation Human Mouse The 4-1BB-dependent immune response Human Mouse The Co-Stimulatory Signal During T-cell Activation Human Mouse

Reactome: 3   Interleukin receptor SHC signaling REACT_23891 Interleukin-3, 5 and GM-CSF signaling REACT_23837 Signaling by Interleukins REACT_22232

NCI-Nature Pathway Interaction Database: 13   Calcineurin-regulated NFAT-dependent transcription in lymphocytes Regulation of Telomerase Glucocorticoid receptor regulatory network IL2-mediated signaling events IL2 signaling events mediated by PI3K AP-1 transcription factor network IL23-mediated signaling events Downstream signaling in naïve CD8+ T cells IL27-mediated signaling events IL2 signaling events mediated by STAT5 Calcium signaling in the CD4+ TCR pathway IL12 signaling mediated by STAT4 IL12-mediated signaling events

Gene Ontology: 37   Negative regulation of protein phosphorylation GO:0001933 Positive regulation of protein phosphorylation GO:0001934 Negative regulation of B cell apoptosis GO:0002903 Cytokine activity GO:0005125 Interleukin-2 receptor binding GO:0005134 Extracellular region GO:0005576 Extracellular space GO:0005615 Anti-apoptosis GO:0006916 Immune response GO:0006955 Cell adhesion GO:0007155 Elevation of cytosolic calcium ion concentration GO:0007204 Activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 Cell-cell signaling GO:0007267 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Kinase activator activity GO:0019209 Natural killer cell activation GO:0030101 T cell differentiation GO:0030217 Carbohydrate binding GO:0030246 Positive regulation of cell growth GO:0030307 Positive regulation of B cell proliferation GO:0030890 Kappa-type opioid receptor binding GO:0031851 Positive regulation of interleukin-17 production GO:0032740 Positive regulation of tissue remodeling GO:0034105 Positive regulation of activated T cell proliferation GO:0042104 Positive regulation of phosphorylation GO:0042327 Positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 Glycosphingolipid binding GO:0043208 Positive regulation of regulatory T cell differentiation GO:0045591 Negative regulation of heart contraction GO:0045822 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Regulation of T cell homeostatic proliferation GO:0046013 Positive regulation of isotype switching to IgG isotypes GO:0048304 Negative regulation of lymphocyte proliferation GO:0050672 Negative regulation of inflammatory response GO:0050728 Positive regulation of inflammatory response GO:0050729 Positive regulation of immunoglobulin secretion GO:0051024

	KEGG Network: 10 Allograft rejection Human - 5330 Mouse - 5330 Rat - 5330 Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Chagas disease (American trypanosomiasis) Human - 5142 Mouse - 5142 Rat - 5142 Cytokine-cytokine receptor interaction Human - 4060 Mouse - 4060 Rat - 4060 Graft-versus-host disease Human - 5332 Mouse - 5332 Rat - 5332 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Jak-STAT signaling pathway Human - 4630 Mouse - 4630 Rat - 4630 Measles Human - 5162 Mouse - 5162 Rat - 5162 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940
	Biocarta: 12 Antigen Dependent B Cell Activation Human Mouse Cytokine Network Human Mouse Cytokines and Inflammatory Response Human Mouse IL 18 Signaling Pathway Human Mouse IL 2 signaling pathway Human Mouse OX40 Signaling Pathway Human Mouse Regulation of hematopoiesis by cytokines Human Mouse Role of Tob in T-cell activation Human Mouse Selective expression of chemokine receptors during T-cell polarization Human Mouse Th1/Th2 Differentiation Human Mouse The 4-1BB-dependent immune response Human Mouse The Co-Stimulatory Signal During T-cell Activation Human Mouse
	Reactome: 3 Interleukin receptor SHC signaling REACT_23891 Interleukin-3, 5 and GM-CSF signaling REACT_23837 Signaling by Interleukins REACT_22232
	NCI-Nature Pathway Interaction Database: 13 Calcineurin-regulated NFAT-dependent transcription in lymphocytes Regulation of Telomerase Glucocorticoid receptor regulatory network IL2-mediated signaling events IL2 signaling events mediated by PI3K AP-1 transcription factor network IL23-mediated signaling events Downstream signaling in naïve CD8+ T cells IL27-mediated signaling events IL2 signaling events mediated by STAT5 Calcium signaling in the CD4+ TCR pathway IL12 signaling mediated by STAT4 IL12-mediated signaling events
	Gene Ontology: 37 Negative regulation of protein phosphorylation GO:0001933 Positive regulation of protein phosphorylation GO:0001934 Negative regulation of B cell apoptosis GO:0002903 Cytokine activity GO:0005125 Interleukin-2 receptor binding GO:0005134 Extracellular region GO:0005576 Extracellular space GO:0005615 Anti-apoptosis GO:0006916 Immune response GO:0006955 Cell adhesion GO:0007155 Elevation of cytosolic calcium ion concentration GO:0007204 Activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway GO:0007205 Cell-cell signaling GO:0007267 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Kinase activator activity GO:0019209 Natural killer cell activation GO:0030101 T cell differentiation GO:0030217 Carbohydrate binding GO:0030246 Positive regulation of cell growth GO:0030307 Positive regulation of B cell proliferation GO:0030890 Kappa-type opioid receptor binding GO:0031851 Positive regulation of interleukin-17 production GO:0032740 Positive regulation of tissue remodeling GO:0034105 Positive regulation of activated T cell proliferation GO:0042104 Positive regulation of phosphorylation GO:0042327 Positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 Glycosphingolipid binding GO:0043208 Positive regulation of regulatory T cell differentiation GO:0045591 Negative regulation of heart contraction GO:0045822 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Regulation of T cell homeostatic proliferation GO:0046013 Positive regulation of isotype switching to IgG isotypes GO:0048304 Negative regulation of lymphocyte proliferation GO:0050672 Negative regulation of inflammatory response GO:0050728 Positive regulation of inflammatory response GO:0050729 Positive regulation of immunoglobulin secretion GO:0051024

Type 1 Diabetes Publications: 56

• Key role for IL-21 in experimental autoimmune uveitis.
  Wang L, Yu CR, Kim HP, Liao W, Telford WG, Egwuagu CE, Leonard WJ
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21593413
   
  
• Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis; a model of type 1 diabetic macrovascular disease.
  Zhou C, Pridgen B, King N, Xu J, Breslow JL
  J Lipid Res. 2011
  PubMed ID: 21606463
   
  
• Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
  Goudy KS, Johnson MC, Garland A, Li C, Samulski RJ, Wang B, Tisch R
  Eur J Immunol. 2011
  PubMed ID: 21469091
   
  
• Inducible Adeno-Associated Virus-Mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes.
  Goudy KS, Johnson MC, Garland A, Li C, Samulski RJ, Wang B, Tisch R
  J Immunol. 2011
  PubMed ID: 21317396
   
  
• Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells.
  Lau-Kilby AW, Kretz CC, Pechhold S, Price JD, Dorta S, Ramos H, Trinchieri G, Tarbell KV
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21262836
   
  
• A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
  Budarf ML, Goyette P, Boucher G, Lian J, Graham RR, Claudio JO, Hudson T, Gladman D, Clarke AE, Pope JE, Peschken C, Smith CD, Hanly J, Rich E, Boire G, Barr SG, Zummer M, GenES Investigators, Fortin PR, Wither J, Rioux JD
  Genes Immun. 2010
  PubMed ID: 20962850
   
  
• Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus.
  Maiti AK, Kim-Howard X, Viswanathan P, Guillén L, Rojas-Villarraga A, Deshmukh H, Direskeneli H, Saruhan-Direskeneli G, Cañas C, Tobön GJ, Sawalha AH, Cherñavsky AC, Anaya JM, Nath SK
  Arthritis Rheum. 2010
  PubMed ID: 20112382
   
  
• IL-2 mediates CD4+ T cell help in the breakdown of memory-like CD8+ T cell tolerance under lymphopenic conditions.
  Le Saout C, Villard M, Cabasse C, Jacquet C, Taylor N, Hernandez J
  PLoS One. 2010
  PubMed ID: 20856822
   
  
• Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significance.
  Hollis-Moffatt JE, Chen-Xu M, Topless R, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, Nissen M, Smith MD, van Rij A, Jones GT, Stamp LK, Merriman TR
  Arthritis Res Ther. 2010
  PubMed ID: 20553587
   
  
• Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.
  Pierce BL, Ahsan H
  Hum Hered. 2010
  PubMed ID: 20203524
   
  
• Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.
  Zhang S, Dai H, Wan N, Moore Y, Dai Z
  PLoS One. 2010
  PubMed ID: 20090908
   
  
• Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.
  McGuire HM, Vogelzang A, Hill N, Flodström-Tullberg M, Sprent J, King C
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19880748
   
  
• Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mouse.
  Kamanaka M, Rainbow D, Schuster-Gossler K, Eynon EE, Chervonsky AV, Wicker LS, Flavell RA
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19549859
   
  
• Multiple sclerosis association study with the TENR-IL2-IL21 region in a Spanish population.
  Fedetz M, Ndagire D, Fernandez O, Leyva L, Guerrero M, Arnal C, Lucas M, Izquierdo G, Delgado C, Alcina A, Matesanz F
  Tissue Antigens. 2009
  PubMed ID: 19523143
   
  
• Genetic variants in the region harbouring IL2/IL21 associated with ulcerative colitis.
  Festen EA, Goyette P, Scott R, Annese V, Zhernakova A, Lian J, Lefèbvre C, Brant SR, Cho JH, Silverberg MS, Taylor KD, de Jong DJ, Stokkers PC, Mcgovern D, Palmieri O, Achkar JP, Xavier RJ, Daly MJ, Duerr RH, Wijmenga C, Weersma RK, Rioux JD
  Gut. 2009
  PubMed ID: 19201773
   
  
• Novel Association of the Interleukin 2-Interleukin 21 Region With Inflammatory Bowel Disease.
  Márquez A, Orozco G, Martínez A, Palomino-Morales R, Fernández-Arquero M, Mendoza JL, Taxonera C, Díaz-Rubio M, Gómez-García M, Nieto A, López-Nevot MA, de la Concha EG, Martín J, Urcelay E
  Am J Gastroenterol. 2009
  PubMed ID: 19471255
   
  
• IL-2 and its high-affinity receptor: Genetic control of immunoregulation and autoimmunity.
  Wang J, Wicker LS, Santamaria P
  Semin Immunol. 2009
  PubMed ID: 19447046
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis.
  Carr EJ, Niederer HA, Williams J, Harper L, Watts RA, Lyons PA, Smith KG
  BMC Med Genet. 2009
  PubMed ID: 19951419
   
  
• Shared and distinct genetic variants in type 1 diabetes and celiac disease.
  Smyth DJ, Plagnol V, Walker NM, Cooper JD, Downes K, Yang JH, Howson JM, Stevens H, McManus R, Wijmenga C, Heap GA, Dubois PC, Clayton DG, Hunt KA, van Heel DA, Todd JA
  N Engl J Med. 2008
  PubMed ID: 19073967
   
  
• Impact of protective IL-2 allelic variants on CD4+ Foxp3+ regulatory T cell function in situ and resistance to autoimmune diabetes in NOD mice.
  Sgouroudis E, Albanese A, Piccirillo CA
  J Immunol. 2008
  PubMed ID: 18941219
   
  
• The IL-2/CD25 Pathway Determines Susceptibility to T1D in Humans and NOD Mice.
  Dendrou CA, Wicker LS
  J Clin Immunol. 2008
  PubMed ID: 18780166
   
  
• Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species.
  Rainbow DB, Esposito L, Howlett SK, Hunter KM, Todd JA, Peterson LB, Wicker LS
  Biochem Soc Trans. 2008
  PubMed ID: 18481948
   
  
• Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice.
  Hamzah J, Nelson D, Moldenhauer G, Arnold B, Hämmerling GJ, Ganss R
  J Clin Invest. 2008
  PubMed ID: 18398504
   
  
• Newly identified genetic risk variants for celiac disease related to the immune response.
  Hunt KA, Zhernakova A, Turner G, Heap GA, Franke L, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GK, Howdle PD, Walters JR, Sanders DS, Playford RJ, Trynka G, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ, Strachan DP, McArdle WL, Mein CA, Wapenaar MC, Deloukas P, McGinnis R, McManus R, Wijmenga C, van Heel DA
  Nat Genet. 2008
  PubMed ID: 18311140
   
  
• Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts.
  Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17670937
   
  
• Effects of cyclosporine on transplant tolerance: the role of IL-2.
  Kang HG, Zhang D, Degauque N, Mariat C, Alexopoulos S, Zheng XX
  Am J Transplant. 2007
  PubMed ID: 17617853
   
  
• Tracing the action of IL-2 in tolerance to islet-specific antigen.
  Liston A, Siggs OM, Goodnow CC
  Immunol Cell Biol. 2007
  PubMed ID: 17372610
   
  
• Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
  Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
  Nat Genet. 2007
  PubMed ID: 17277778
   
  
• Sjögren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice: gender differences in keratoconjunctivitis sicca defined by a cross-over in the chromosome 3 Aec1 locus.
  Nguyen C, Singson E, Kim JY, Cornelius JG, Attia R, Doyle ME, Bulosan M, Cha S, Peck AB
  Scand J Immunol. 2006
  PubMed ID: 16918699
   
  
• Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A.
  Sumnik Z, Cinek O, Bratanic N, Kordonouri O, Kulich M, Roszai B, Arato A, Lebl J, Soltesz G, Danne T, Battelino T, Schober E
  Diabetes Care. 2006
  PubMed ID: 16567828
   
  
• Defective induction of CTLA-4 in the NOD mouse is controlled by the NOD allele of Idd3/IL-2 and a novel locus (Ctex) telomeric on chromosome 1.
  Lundholm M, Motta V, Löfgren-Burström A, Duarte N, Bergman ML, Mayans S, Holmberg D
  Diabetes. 2006
  PubMed ID: 16443792
   
  
• Serum IL-1beta, IL-2, and IL-6 in insulin-dependent diabetic children.
  Dogan Y, Akarsu S, Ustundag B, Yilmaz E, Gurgoze MK
  Mediators Inflamm. 2006
  PubMed ID: 16864906
   
  
• Idd1 and Idd3 are necessary but not sufficient for development of type 1 diabetes in NOD mouse.
  Ikegami H, Fujisawa T, Sakamoto T, Makino S, Ogihara T
  Diabetes Res Clin Pract. 2004
  PubMed ID: 15563987
   
  
• Helper requirements for generation of effector CTL to islet beta cell antigens.
  Behrens GM, Li M, Davey GM, Allison J, Flavell RA, Carbone FR, Heath WR
  J Immunol. 2004
  PubMed ID: 15100283
   
  
• Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.
  Ikegami H, Fujisawa T, Makino S, Ogihara T
  Ann N Y Acad Sci. 2003
  PubMed ID: 14679059
   
  
• Either IL-2 or IL-12 is sufficient to direct Th1 differentiation by nonobese diabetic T cells.
  Zhou W, Zhang F, Aune TM
  J Immunol. 2003
  PubMed ID: 12517935
   
  
• Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjögren's syndrome) on a healthy murine background.
  Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG
  Arthritis Rheum. 2002
  PubMed ID: 12115247
   
  
• Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping.
  Ikegami H, Fujisawa T, Makino S, Ogihara T
  Ann N Y Acad Sci. 2002
  PubMed ID: 12021134
   
  
• IDD3 and IDD5 alleles from nod mice mediate Sjögren's syndrome-like autoimmunity.
  Cha S, Nagashima H, Peck AB, Humphreys-Beher MG
  Adv Exp Med Biol. 2002
  PubMed ID: 12614028
   
  
• Interleukin-2 signaling and the maintenance of self-tolerance.
  Nelson BH
  Curr Dir Autoimmun. 2002
  PubMed ID: 11826762
   
  
• Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene?
  Podolin PL, Wilusz MB, Cubbon RM, Pajvani U, Lord CJ, Todd JA, Peterson LB, Wicker LS, Lyons PA
  Cytokine. 2000
  PubMed ID: 10857762
   
  
• Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.
  Lyons PA, Armitage N, Argentina F, Denny P, Hill NJ, Lord CJ, Wilusz MB, Peterson LB, Wicker LS, Todd JA
  Genome Res. 2000
  PubMed ID: 10779485
   
  
• Induction of allograft tolerance in the absence of Fas-mediated apoptosis.
  Li XC, Li Y, Dodge I, Wells AD, Zheng XX, Turka LA, Strom TB
  J Immunol. 1999
  PubMed ID: 10452986
   
  
• QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2.
  Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK
  Nat Genet. 1999
  PubMed ID: 9988264
   
  
• IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection.
  Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, Li Y, Zheng XX, Nickerson PW, Steiger J, Malek TR, Strom TB
  J Immunol. 1998
  PubMed ID: 9670967
   
  
• Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.
  Denny P, Lord CJ, Hill NJ, Goy JV, Levy ER, Podolin PL, Peterson LB, Wicker LS, Todd JA, Lyons PA
  Diabetes. 1997
  PubMed ID: 9075813
   
  
• IL-2 and IL-4 double knock-out mice reject islet allografts: a role for novel T-cell growth factors?
  Roy-Chaudhury P, Manfro RC, Steiger J, Nickerson PW, Tian Y, Zheng XX, Li YS, Strom TB
  Transplant Proc. 1997
  PubMed ID: 9123210
   
  
• Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits.
  Yui MA, Muralidharan K, Moreno-Altamirano B, Perrin G, Chestnut K, Wakeland EK
  Mamm Genome. 1996
  PubMed ID: 8661724
   
  
• Aod2, the locus controlling development of atrophy in neonatal thymectomy-induced autoimmune ovarian dysgenesis, co-localizes with Il2, Fgfb, and Idd3.
  Teuscher C, Wardell BB, Lunceford JK, Michael SD, Tung KS
  J Exp Med. 1996
  PubMed ID: 8627174
   
  
• Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.
  Ikegami H, Makino S, Yamato E, Kawaguchi Y, Ueda H, Sakamoto T, Takekawa K, Ogihara T
  J Clin Invest. 1995
  PubMed ID: 7560085
   
  
• Crosses of NOD mice with the related NON strain. A polygenic model for IDDM.
  McAleer MA, Reifsnyder P, Palmer SM, Prochazka M, Love JM, Copeman JB, Powell EE, Rodrigues NR, Prins JB, Serreze DV
  Diabetes. 1995
  PubMed ID: 7556956
   
  
• IL-2 knockout recipient mice reject islet cell allografts.
  Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB
  J Immunol. 1995
  PubMed ID: 7602120
   
  
• Polygenic control of autoimmune diabetes in nonobese diabetic mice.
  Ghosh S, Palmer SM, Rodrigues NR, Cordell HJ, Hearne CM, Cornall RJ, Prins JB, McShane P, Lathrop GM, Peterson LB
  Nat Genet. 1993
  PubMed ID: 8401590
   
  
• Characterizations of candidate genes for IDD susceptibility from the diabetes-prone NOD mouse strain.
  Chesnut K, She JX, Cheng I, Muralidharan K, Wakeland EK
  Mamm Genome. 1993
  PubMed ID: 8268651
   
  
• Genetic analysis of autoimmune type 1 diabetes mellitus in mice.
  Todd JA, Aitman TJ, Cornall RJ, Ghosh S, Hall JR, Hearne CM, Knight AM, Love JM, McAleer MA, Prins JB
  Nature. 1991
  PubMed ID: 1675432
   
  

Publications: 973

• Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritis.
  Ronaghy A, de Jager W, Zonneveld-Huijssoon E, Klein MR, van Wijk F, Rijkers GT, Kuis W, Wulffraat NM, Prakken BJ
  Ann Rheum Dis. 2011
  PubMed ID: 21859687
   
  
• In vivo effect of surfactant on inflammatory cytokines during endotoxin-induced lung injury in rodents.
  Mittal N, Sanyal SN
  J Immunotoxicol. 2011
  PubMed ID: 21767135
   
  
• Local inflammatory markers and systemic endotoxin in aggressive periodontitis.
  Shaddox LM, Wiedey J, Calderon NL, Magnusson I, Bimstein E, Bidwell JA, Zapert EF, Aukhil I, Wallet SM
  J Dent Res. 2011
  PubMed ID: 21730256
   
  
• Involvement of NK 1.1-positive γδT cells in interleukin-18 plus interleukin-2-induced interstitial lung disease.
  Segawa S, Goto D, Yoshiga Y, Horikoshi M, Sugihara M, Hayashi T, Chino Y, Matsumoto I, Ito S, Sumida T
  Am J Respir Cell Mol Biol. 2011
  PubMed ID: 21257923
   
  
• Rapamycin and IL-2 reduce lethal acute graft-versus-host disease associated with increased expansion of donor type CD4+CD25+Foxp3+ regulatory T cells.
  Shin HJ, Baker J, Leveson-Gower DB, Smith AT, Sega EI, Negrin RS
  Blood. 2011
  PubMed ID: 21734238
   
  
• IL-2 may possess neuroprotective properties in glaucomatous optic neuropathy.
  Hautala N, Glumoff V, Hautala T, Vainio O
  Acta Ophthalmol. 2011
  PubMed ID: 21834929
   
  
• Efficacy of large doses of IL-2-activated human leukocyte antigen haploidentical peripheral blood stem cells on refractory metastatic renal cell carcinoma.
  Cao S, Wang YL, Ren XB, Yu JP, Ren BZ, Zhang XW, Zhang WH, Han Y
  Cancer Biother Radiopharm. 2011
  PubMed ID: 21812652
   
  
• Intraocular interleukin-17 and proinflammatory cytokines in HLA-A29-associated birdshot chorioretinopathy.
  Kuiper JJ, Mutis T, de Jager W, de Groot-Mijnes JD, Rothova A
  Am J Ophthalmol. 2011
  PubMed ID: 21570674
   
  
• Loss of CNS IL-2 gene expression modifies brain T lymphocyte trafficking: response of normal versus autoreactive Treg-deficient T cells.
  Huang Z, Meola D, Petitto JM
  Neurosci Lett. 2011
  PubMed ID: 21669253
   
  
• Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
  Höglinger GU, Melhem NM, Dickson DW, Sleiman PM, Wang LS, Klei L, Rademakers R, de Silva R, Litvan I, Riley DE, van Swieten JC, Heutink P, Wszolek ZK, Uitti RJ, Vandrovcova J, Hurtig HI, Gross RG, Maetzler W, Goldwurm S, Tolosa E, Borroni B, Pastor P, PSP Genetics Study Group, Cantwell LB, Han MR, Dillman A, van der Brug MP, Gibbs JR, Cookson MR, Hernandez DG, Singleton AB, Farrer MJ, Yu CE, Golbe LI, Revesz T, Hardy J, Lees AJ, Devlin B, Hakonarson H, Müller U, Schellenberg GD
  Nat Genet. 2011
  PubMed ID: 21685912
   
  
• Association of interleukin-2, interleukin-4 and transforming growth factor-beta gene polymorphisms with Behcet's disease.
  Shahram F, Nikoopour E, Rezaei N, Saeedfar K, Ziaei N, Davatchi F, Amirzargar A
  Clin Exp Rheumatol. 2011
  PubMed ID: 21640045
   
  
• Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells.
  Dubrac S, Elentner A, Schoonjans K, Auwerx J, Schmuth M
  Eur J Immunol. 2011
  PubMed ID: 21509781
   
  
• HIV-1 p17 matrix protein interacts with heparan sulfate side chain of CD44v3, syndecan-2, and syndecan-4 proteoglycans expressed on human activated CD4+ T cells affecting tumor necrosis factor alpha and interleukin 2 production.
  De Francesco MA, Baronio M, Poiesi C
  J Biol Chem. 2011
  PubMed ID: 21482826
   
  
• Endothelial nitric oxide synthase is a key mediator of interleukin-2-induced hypotension and vascular leak syndrome.
  Samlowski WE, Kondapaneni M, Tharkar S, McGregor JR, Laubach VE, Salvemini D
  J Immunother. 2011
  PubMed ID: 21577143
   
  
• Impact of endothelial activation on infective and inflammatory complications after cardiac surgery in type II diabetes mellitus.
  Onorati F, Rubino AS, Cuda A, Foti D, Sica V, Santini F, Gulletta E, Renzulli A
  Int J Artif Organs. 2011
  PubMed ID: 21574159
   
  
• Papillomavirus-specific CD4+ T cells exhibit reduced STAT-5 signaling and altered cytokine profiles in patients with recurrent respiratory papillomatosis.
  James EA, DeVoti JA, Rosenthal DW, Hatam LJ, Steinberg BM, Abramson AL, Kwok WW, Bonagura VR
  J Immunol. 2011
  PubMed ID: 21531896
   
  
• Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages.
  Liao W, Lin JX, Wang L, Li P, Leonard WJ
  Nat Immunol. 2011
  PubMed ID: 21516110
   
  
• Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9.
  Janse M, Lamberts LE, Franke L, Raychaudhuri S, Ellinghaus E, Muri Boberg K, Melum E, Folseraas T, Schrumpf E, Bergquist A, Björnsson E, Fu J, Jan Westra H, Groen HJ, Fehrmann RS, Smolonska J, van den Berg LH, Ophoff RA, Porte RJ, Weismüller TJ, Wedemeyer J, Schramm C, Sterneck M, Günther R, Braun F, Vermeire S, Henckaerts L, Wijmenga C, Ponsioen CY, Schreiber S, Karlsen TH, Franke A, Weersma RK
  Hepatology. 2011
  PubMed ID: 21425313
   
  
• Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21.
  Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martín J, Brown EE, Vilá LM, Alarcón GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcón-Riquelme ME, BIOLUPUS Network, Nath SK, Harley JB, Sawalha AH
  Arthritis Rheum. 2011
  PubMed ID: 21425124
   
  
• Antiviral role of toll-like receptors and cytokines against the new 2009 H1N1 virus infection.
  Liu Y, Chen H, Sun Y, Chen F
  Mol Biol Rep. 2011
  PubMed ID: 21603856
   
  
• Prolonged antitumor NK cell reactivity elicited by CXCL10-expressing dendritic cells licensed by CD40L+ CD4+ memory T cells.
  Shimizu K, Asakura M, Fujii S
  J Immunol. 2011
  PubMed ID: 21460206
   
  
• CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis.
  McNally A, Hill GR, Sparwasser T, Thomas R, Steptoe RJ
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21502514
   
  
• Interleukin-2 profiles shortly after tacrolimus conversion from a twice-daily to once-daily regimen.
  Meçule A, Tinti F, Bachetoni A, Poli L, D'Alessandro M, Alessandri C, Umbro I, Nofroni I, Berloco PB, Mitterhofer AP
  Transplant Proc. 2011
  PubMed ID: 21620040
   
  
• A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy.
  Wuest SC, Edwan JH, Martin JF, Han S, Perry JS, Cartagena CM, Matsuura E, Maric D, Waldmann TA, Bielekova B
  Nat Med. 2011
  PubMed ID: 21532597
   
  
• Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model.
  Lisiero DN, Soto H, Liau LM, Prins RM
  J Immunol. 2011
  PubMed ID: 21430221
   
  
• Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.
  Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD
  J Immunol. 2011
  PubMed ID: 21389258
   
  
• IL-2 contributes to maintaining a balance between CD4+Foxp3+ regulatory T cells and effector CD4+ T cells required for immune control of blood-stage malaria infection.
  Berretta F, St-Pierre J, Piccirillo CA, Stevenson MM
  J Immunol. 2011
  PubMed ID: 21389253
   
  
• IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.
  Orange JS, Roy-Ghanta S, Mace EM, Maru S, Rak GD, Sanborn KB, Fasth A, Saltzman R, Paisley A, Monaco-Shawver L, Banerjee PP, Pandey R
  J Clin Invest. 2011
  PubMed ID: 21383498
   
  
• Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.
  Konkel JE, Maruyama T, Carpenter AC, Xiong Y, Zamarron BF, Hall BE, Kulkarni AB, Zhang P, Bosselut R, Chen W
  Nat Immunol. 2011
  PubMed ID: 21297643
   
  
• CD4+ T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs.
  Sun J, Dodd H, Moser EK, Sharma R, Braciale TJ
  Nat Immunol. 2011
  PubMed ID: 21297642
   
  
• Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production.
  Wong WF, Kurokawa M, Satake M, Kohu K
  J Biol Chem. 2011
  PubMed ID: 21292764
   
  
• Protein kinases JAK and ERK mediate protective effect of interleukin-2 upon ganglion cells of the developing rat retina.
  Marra C, Gomes Moret D, de Souza Corrêa A, Chagas da Silva F, Moraes P, Linden R, Sholl-Franco A
  J Neuroimmunol. 2011
  PubMed ID: 21262542
   
  
• Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.
  Chen Y, Haines CJ, Gutcher I, Hochweller K, Blumenschein WM, McClanahan T, Hämmerling G, Li MO, Cua DJ, McGeachy MJ
  Immunity. 2011
  PubMed ID: 21435588
   
  
• A systematic investigation of confirmed autoimmune loci in early-onset psoriasis reveals an association with IL2/IL21.
  Warren RB, Smith RL, Flynn E, Bowes J, UKRAG Consortium, Eyre S, Worthington J, Barton A, Griffiths CE
  Br J Dermatol. 2011
  PubMed ID: 21375519
   
  
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
  Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD
  Nat Genet. 2011
  PubMed ID: 21297633
   
  
• IL-2: a two-faced master regulator of autoimmunity.
  Sharma R, Fu SM, Ju ST
  J Autoimmun. 2011
  PubMed ID: 21282039
   
  
• Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5.
  Yang XP, Ghoreschi K, Steward-Tharp SM, Rodriguez-Canales J, Zhu J, Grainger JR, Hirahara K, Sun HW, Wei L, Vahedi G, Kanno Y, O'Shea JJ, Laurence A
  Nat Immunol. 2011
  PubMed ID: 21278738
   
  
• Increased T regulatory cells and decreased Th1 pro-inflammatory cytokines correlate with culture-positive infection in febrile neutropenia childhood oncology patients.
  Hodge G, Scott J, Osborn M, To LB, Zola H, Hodge S, Revesz T
  Cytokine. 2011
  PubMed ID: 21167738
   
  
• Intravesical immune suppression by liposomal tacrolimus in cyclophosphamide-induced inflammatory cystitis.
  Chuang YC, Tyagi P, Huang HY, Yoshimura N, Wu M, Kaufman J, Chancellor MB
  Neurourol Urodyn. 2011
  PubMed ID: 20860016
   
  
• NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.
  Kuylenstierna C, Snyder-Cappione JE, Loo CP, Long BR, Gonzalez VD, Michaëlsson J, Moll M, Spotts G, Hecht FM, Nixon DF, Sandberg JK
  Scand J Immunol. 2011
  PubMed ID: 21198755
   
  
• Mitogenic response and cytokine production induced by cramoll 1,4 lectin in splenocytes of inoculated mice.
  de Melo CM, Melo H, Correia MT, Coelho LC, da Silva MB, Pereira VR
  Scand J Immunol. 2011
  PubMed ID: 21198751
   
  
• TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling.
  Motegi H, Shimo Y, Akiyama T, Inoue J
  Genes Cells. 2011
  PubMed ID: 21155952
   
  
• IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation.
  Sharma R, Sharma PR, Kim YC, Leitinger N, Lee JK, Fu SM, Ju ST
  J Immunol. 2011
  PubMed ID: 21169543
   
  
• Type I IFN substitutes for T cell help during viral infections.
  Wiesel M, Kratky W, Oxenius A
  J Immunol. 2011
  PubMed ID: 21160039
   
  
• Acute exhaustive exercise regulates IL-2, IL-4 and MyoD in skeletal muscle but not adipose tissue in rats.
  Rosa Neto JC, Lira FS, Zanchi NE, Oyama LM, Pimentel GD, Santos RV, Seelaender M, Oller do Nascimento CM
  Lipids Health Dis. 2011
  PubMed ID: 21668966
   
  
• The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection.
  Watkins RL, Pallister KB, Voyich JM
  PLoS One. 2011
  PubMed ID: 21603642
   
  
• Plasmodium berghei ANKA infection increases Foxp3, IL-10 and IL-2 in CXCL-10 deficient C57BL/6 mice.
  Sarfo BY, Wilson NO, Bond VC, Stiles JK
  Malar J. 2011
  PubMed ID: 21439091
   
  
• Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states.
  Sester U, Fousse M, Dirks J, Mack U, Prasse A, Singh M, Lalvani A, Sester M
  PLoS One. 2011
  PubMed ID: 21423578
   
  
• IL-2 suppression of IL-12p70 by a recombinant HSV-1 expressing IL-2 induces T-cell auto-reactivity and CNS demyelination.
  Zandian M, Mott KR, Allen SJ, Chen S, Arditi M, Ghiasi H
  PLoS One. 2011
  PubMed ID: 21364747
   
  
• Role of the rs6822844 gene polymorphism at the IL2-IL21 region in biopsy-proven giant cell arteritis.
  Rodríguez-Rodríguez L, Castañeda S, Vázquez-Rodríguez TR, Morado IC, Gómez-Vaquero C, Marí-Alfonso B, Miranda-Filloy JA, Narvaez J, Ortego-Centeno N, Vicente EF, Blanco R, Amigo-Diaz E, Fernández-Gutiérrez B, Martin J, González-Gay MA
  Clin Exp Rheumatol. 2011
  PubMed ID: 21269573
   
  
• Human activated CD4(+) T lymphocytes increase IL-2 expression by downregulating microRNA-181c.
  Xue Q, Guo ZY, Li W, Wen WH, Meng YL, Jia LT, Wang J, Yao LB, Jin BQ, Wang T, Yang AG
  Mol Immunol. 2011
  PubMed ID: 21112091
   
  
• Chronic colitis induces expression of β-defensins in murine intestinal epithelial cells.
  Rahman A, Fahlgren A, Sundstedt C, Hammarström S, Danielsson A, Hammarström ML
  Clin Exp Immunol. 2011
  PubMed ID: 21039426
   
  
• Production of IFN-γ by CD4(+) T cells in response to malaria antigens is IL-2 dependent.
  Kimura D, Miyakoda M, Honma K, Shibata Y, Yuda M, Chinzei Y, Yui K
  Int Immunol. 2010
  PubMed ID: 21059770
   
  
• Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
  Barron L, Dooms H, Hoyer KK, Kuswanto W, Hofmann J, O'Gorman WE, Abbas AK
  J Immunol. 2010
  PubMed ID: 21037099
   
  
• IL-2 complex treatment can protect naive mice from bacterial and viral infection.
  Hamilton SE, Schenkel JM, Akue AD, Jameson SC
  J Immunol. 2010
  PubMed ID: 21037095
   
  
• IL-2 and IL-4 stimulate MEK1 expression and contribute to T cell resistance against suppression by TGF-beta and IL-10 in asthma.
  Liang Q, Guo L, Gogate S, Karim Z, Hanifi A, Leung DY, Gorska MM, Alam R
  J Immunol. 2010
  PubMed ID: 20926789
   
  
• Hodgkin disease risk: Role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes.
  Monroy CM, Cortes AC, Lopez MS, D'Amelio AM, Etzel CJ, Younes A, Strom SS, El-Zein RA
  Mol Carcinog. 2010
  PubMed ID: 21061265
   
  
• Th cells act via two synergistic pathways to promote antiviral CD8+ T cell responses.
  Wiesel M, Joller N, Ehlert AK, Crouse J, Spörri R, Bachmann MF, Oxenius A
  J Immunol. 2010
  PubMed ID: 20881183
   
  
• IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase CbetaI.
  Zhu P, Jiang W, Cao L, Yu W, Pei Y, Yang X, Wan B, Liu JO, Yi Q, Yu L
  J Immunol. 2010
  PubMed ID: 20870937
   
  
• Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors.
  Decker T, Bogner C, Oelsner M, Peschel C, Ringshausen I
  Ann Hematol. 2010
  PubMed ID: 20544350
   
  
• Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
  Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
  Arthritis Rheum. 2010
  PubMed ID: 20973039
   
  
• The functional significance of the TGM2 gene in schizophrenia: A correlation of SNPs and circulating IL-2 levels.
  Bradford M, Law MH, Megson IL, Wei J
  J Neuroimmunol. 2010
  PubMed ID: 20926141
   
  
• Role of interleukin-18 in human natural killer cell is associated with interleukin-2.
  Huang Y, Lei Y, Zhang H, Zhang M, Dayton A
  Mol Immunol. 2010
  PubMed ID: 21035858
   
  
• Abrogating Cbl-b in effector CD8(+) T cells improves the efficacy of adoptive therapy of leukemia in mice.
  Stromnes IM, Blattman JN, Tan X, Jeevanjee S, Gu H, Greenberg PD
  J Clin Invest. 2010
  PubMed ID: 20890046
   
  
• The influence of upstream IL-2 -330 (T/G) and TNF-α -308 (A/G) polymorphisms on glutamine-supplemented cytokine release.
  Müller T, Topp T, Weismüller K, Kwapisz M, Engel J
  Scand J Immunol. 2010
  PubMed ID: 20883322
   
  
• A multiplex MALDI-TOF MS approach facilitates genotyping of DNA from formalin-fixed paraffin-embedded tumour specimens.
  Horn H, Pott C, Kalla J, Dreyling M, Rosenwald A, Ott G, Schwab M, Schaeffeler E
  Pharmacogenet Genomics. 2010
  PubMed ID: 20802378
   
  
• Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection.
  Molloy M, Zhang W, Usherwood E
  J Virol. 2010
  PubMed ID: 20686022
   
  
• A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
  Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20673868
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis.
  Shahbazi M, Roshandel D, Ebadi H, Fathi D, Zamani M, Boghaee M, Mohammadhoseeeni M, Rshaidbaghan A, Bakhshandeh A, Shahbazi S
  Clin Immunol. 2010
  PubMed ID: 20594918
   
  
• In CD28-costimulated human naïve CD4+ T cells, I-κB kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms.
  Lupino E, Buccinnà B, Ramondetti C, Lomartire A, De Marco G, Ricotti E, Tovo PA, Rinaudo MT, Piccinini M
  Immunology. 2010
  PubMed ID: 20465575
   
  
• Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases.
  Morer A, Chae W, Henegariu O, Bothwell AL, Leckman JF, Kawikova I
  Brain Behav Immun. 2010
  PubMed ID: 20193755
   
  
• In vitro propagation and dynamics of T cells from skin biopsies by methods using interleukins-2 and -4 or anti-CD3/CD28 antibody-coated microbeads.
  Hashizume H, Hansen A, Poulsen LK, Thomsen AR, Takigawa M, Thestrup-Pedersen K
  Acta Derm Venereol. 2010
  PubMed ID: 20814620
   
  
• Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.
  Chang JS, Wiemels JL, Chokkalingam AP, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Green J, May SL, Kiley VA, Wiencke JK, Buffler PA
  Cancer Epidemiol Biomarkers Prev. 2010
  PubMed ID: 20716621
   
  
• NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination.
  Horowitz A, Behrens RH, Okell L, Fooks AR, Riley EM
  J Immunol. 2010
  PubMed ID: 20679529
   
  
• IL1RN VNTR and IL2-330 polymorphic genes are independently associated with chronic immune thrombocytopenia.
  Rocha AM, De Souza C, Rocha GA, De Melo FF, Saraiva IS, Clementino NC, Marino MC, Queiroz DM
  Br J Haematol. 2010
  PubMed ID: 20626741
   
  
• IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis.
  Kameyama K, Nemoto Y, Kanai T, Shinohara T, Okamoto R, Tsuchiya K, Nakamura T, Sakamoto N, Totsuka T, Hibi T, Watanabe M
  Eur J Immunol. 2010
  PubMed ID: 20623548
   
  
• IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation.
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• Interleukin-2 as a neuromodulator possibly implicated in the physiopathology of sudden infant death syndrome.
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• Primed antigen-specific CD4+ T cells are required for NK cell activation in vivo upon Leishmania major infection.
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• Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat model.
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• Helicobacter pylori infection and cytokine gene polymorphisms in Uzbeks.
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• IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation.
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• A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients.
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• Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood.
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• Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
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• Tissue expression of interleukin 2 (IL-2) and IL-2 receptor (IL-2R(alpha)/CD25) in non-Hodgkin B-cell lymphomas in children: correlations with clinical data.
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• The C-terminal region of human NFATc2 binds cJun to synergistically activate interleukin-2 transcription.
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• Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers.
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• Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
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• Cytokine gene polymorphisms in sarcoidosis.
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• Effect of gene polymorphisms on the levels of calcineurin inhibitors in Indian renal transplant recipients.
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• Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
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• Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization.
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• IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents.
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• A Large-scale genetic association study of esophageal adenocarcinoma risk.
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• Association of the interleukin-2 polymorphisms with interleukin-2 serum levels and risk of nasopharyngeal carcinoma.
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• Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.
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• The genes encoding cytokines IL-2, IL-10 and IL-12B are primary 1alpha,25(OH)2D3 target genes.
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• IL-2 and IFN-gamma in the retina of diabetic rats.
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• Distinct roles for IL-2 and IL-15 in the differentiation and survival of CD8+ effector and memory T cells.
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• TRAF6 inhibits Th17 differentiation and TGF-beta-mediated suppression of IL-2.
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• Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
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• Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
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  Nat Genet. 2010
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• Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
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• Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
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• Evidence that cervical cancer cells secrete IL-2, which becomes an autocrine growth factor.
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• Interleukin-2 enhances dendritic development and spinogenesis in cultured hippocampal neurons.
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• Reciprocal granzyme/perforin-mediated death of human regulatory and responder T cells is regulated by interleukin-2 (IL-2).
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• Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft-versus-host disease through up-regulating suppressors of cytokine signalling-3 expression of naive CD4+ T cells.
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• Inhibition of transforming growth factor-beta signalling attenuates interleukin (IL)-18 plus IL-2-induced interstitial lung disease in mice.
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• Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
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• Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
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• C-reactive protein -717C>T genetic polymorphism associates with esophagectomy-induced stress hyperglycemia.
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• IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.
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• Galpha12 is critical for TCR-induced IL-2 production and differentiation of T helper 2 and T helper 17 cells.
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• Graves' disease and gene polymorphism of TNF-α, IL-2, IL-6, IL-12, and IFN-γ.
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• Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity.
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• Multiple common variants for celiac disease influencing immune gene expression.
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• Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease.
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• IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs).
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• Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
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• Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer.
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• The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register.
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• Cytokine polymorphisms and Alzheimer disease: possible associations.
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  Neurol Sci. 2010
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• Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
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• Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis.
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  Genes Immun. 2010
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• The association of IL-1beta, IL-2, and IL-6 gene polymorphisms with bone mineral density and osteoporosis in postmenopausal women.
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• c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells.
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• Shockwaves increase T-cell proliferation and IL-2 expression through ATP release, P2X7 receptors, and FAK activation.
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• Knockdown of interleukin-2 by shRNA-mediated RNA interference prolongs liver allograft survival.
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• Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk.
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• T-Helper 1, T-Helper 2, and T-Regulatory Cytokines Gene Polymorphisms in Irritable Bowel Syndrome.
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• Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments.
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• IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
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• Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
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• Immunogenetic characteristics of patients with autoimmune gastritis.
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• RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells.
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• An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes.
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• Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
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• Characterization of protective human CD4CD25 FOXP3 regulatory T cells generated with IL-2, TGF-β and retinoic acid.
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• The DTH effector response and IL-2 are unaffected by cyclosporine A in autoimmune B6D2F1 mice.
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• Cytokine gene polymorphisms and risk for upper respiratory symptoms in highly-trained athletes.
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• Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
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• L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
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• Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells.
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• The 4q27 locus and prostate cancer risk.
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• CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production.
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• Genetic risk factors for periodontitis in a Japanese population.
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• Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
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• Polymorphisms of some cytokines and chronic hepatitis B and C virus infection.
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• Dendritic cell transfected with secondary lymphoid-tissue chemokine and/or interleukin-2 gene-enhanced cytotoxicity of T-lymphocyte in human bladder tumor cell S in vitro.
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• Interferon-gamma 874A>T genetic polymorphism is associated with infectious complications following surgery in patients with thoracic esophageal cancer.
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• Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.
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• Common and different genetic background for rheumatoid arthritis and coeliac disease.
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• Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.
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  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19805141
   
  
• Role of inflammation gene polymorphisms on pain severity in lung cancer patients.
  Reyes-Gibby CC, Spitz MR, Yennurajalingam S, Swartz M, Gu J, Wu X, Bruera E, Shete S
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19773451
   
  
• IL2-330G polymorphic allele is associated with decreased risk of Helicobacter pylori infection in adulthood.
  Queiroz DM, Saraiva IE, Rocha GA, Rocha AM, Gomes LI, Melo FF, Bittencourt PF
  Microbes Infect. 2009
  PubMed ID: 19638314
   
  
• Interleukin-2 -330 and 166 gene polymorphisms in relation to aggressive or chronic periodontitis and the presence of periodontopathic bacteria.
  Reichert S, Machulla HK, Klapproth J, Zimmermann U, Reichert Y, Gläser C, Schaller HG, Schulz S
  J Periodontal Res. 2009
  PubMed ID: 19453859
   
  
• ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury.
  Li X, Chaudry IH, Choudhry MA
  J Immunol. 2009
  PubMed ID: 19710466
   
  
• Interleukin-2 gene transfer potentiates the alpha-galactosylceramide-stimulated antitumor effect by the induction of TRAIL in NKT and NK cells in mouse models of subcutaneous and metastatic carcinoma.
  Nishihori Y, Kato K, Tanaka M, Okamoto T, Hagiwara S, Araki N, Kogawa K, Kuribayashi K, Nakamura K, Niitsu Y
  Cancer Biol Ther. 2009
  PubMed ID: 19901518
   
  
• Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation.
  Gutermuth J, Nograles KE, Miyagawa F, Nelson E, Cho YH, Katz SI
  J Immunol. 2009
  PubMed ID: 19675167
   
  
• X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms.
  Sharma R, Deshmukh US, Zheng L, Fu SM, Ju ST
  J Immunol. 2009
  PubMed ID: 19648271
   
  
• Assessment of 14 functional gene polymorphisms in Japanese patients with oral lichen planus: a pilot case-control study.
  Fujita H, Kobayashi T, Tai H, Nagata M, Hoshina H, Nishizawa R, Takagi R, Yoshie H
  Int J Oral Maxillofac Surg. 2009
  PubMed ID: 19497711
   
  
• CRP genetic polymorphism is associated with lymph node metastasis in thoracic esophageal squamous cell cancer.
  Motoyama S, Miura M, Hinai Y, Maruyama K, Usami S, Saito H, Minamiya Y, Satoh S, Murata K, Suzuki T, Ogawa J
  Ann Surg Oncol. 2009
  PubMed ID: 19495883
   
  
• A cytokine study in children and adolescents with Tourette's disorder.
  Gabbay V, Coffey BJ, Guttman LE, Gottlieb L, Katz Y, Babb JS, Hamamoto MM, Gonzalez CJ
  Prog Neuropsychopharmacol Biol Psychiatry. 2009
  PubMed ID: 19427348
   
  
• Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development.
  Le Campion A, Gagnerault MC, Auffray C, Bécourt C, Poitrasson-Rivière M, Lallemand E, Bienvenu B, Martin B, Lepault F, Lucas B
  Blood. 2009
  PubMed ID: 19561321
   
  
• The PTPN22(gain-of-function)+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.
  Chuang WY, Ströbel P, Belharazem D, Rieckmann P, Toyka KV, Nix W, Schalke B, Gold R, Kiefer R, Klinker E, Opitz A, Inoue M, Kuo TT, Müller-Hermelink HK, Marx A
  Genes Immun. 2009
  PubMed ID: 19693092
   
  
• Four novel coeliac disease regions replicated in an association study of a Swedish-Norwegian family cohort.
  Amundsen SS, Rundberg J, Adamovic S, Gudjónsdóttir AH, Ascher H, Ek J, Nilsson S, Lie BA, Naluai AT, Sollid LM
  Genes Immun. 2009
  PubMed ID: 19693089
   
  
• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
  Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
  Eur Urol. 2009
  PubMed ID: 19692168
   
  
• Allelic polymorphism of cytokine genes during pulmonary tuberculosis.
  Naslednikova IO, Urazova OI, Voronkova OV, Strelis AK, Novitsky VV, Nikulina EL, Hasanova RR, Kononova TE, Serebryakova VA, Vasileva OA, Suhalentseva NA, Churina EG, Kolosova AE, Fedorovich TV
  Bull Exp Biol Med. 2009
  PubMed ID: 20027321
   
  
• Distribution of cytokine gene polymorphisms in the general Lebanese population: the first report.
  Mahfouz RA, Shammaa D, Harb N, Halas H, Sarafian K, Zaatari G, Bazarbachi A
  Genet Test Mol Biomarkers. 2009
  PubMed ID: 19594368
   
  
• Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
  Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
  Br J Haematol. 2009
  PubMed ID: 19573080
   
  
• Decreased 4-1BB expression on HIV-specific CD4+ T cells is associated with sustained viral replication and reduced IL-2 production.
  Kassu A, D'Souza M, O'Connor BP, Kelly-McKnight E, Akkina R, Fontenot AP, Palmer BE
  Clin Immunol. 2009
  PubMed ID: 19406689
   
  
• PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  Hosgood HD, Menashe I, He X, Chanock S, Lan Q
  Respir Med. 2009
  PubMed ID: 19625176
   
  
• IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation.
  Sharma R, Sung SS, Abaya CE, Ju AC, Fu SM, Ju ST
  J Immunol. 2009
  PubMed ID: 19553521
   
  
• Serum tumor necrosis factor-alpha and interleukin-2 concentrations in newly diagnosed ERBB2 (HER2/neu) positive breast cancer patients.
  Saglam S, Suzme R, Gurdol F
  Int J Biol Markers. 2009
  PubMed ID: 19787624
   
  
• [Allelic polymorphism of the IL-2and IL-4 genes in herpesvirus infection]
  Naslednikova IO, Novitskiĭ VV, Urazova OI, Gorbunova EB, Sukhalentseva NA, Chernov AS, Reshetnikov VI, Shperling NV, Pronina NA, Chaĭkovskiĭ AV, Chernova EN, Bezmenova MA, Sharopina AV, Voronkova OV
  Klin Lab Diagn. 2009
  PubMed ID: 19718824
   
  
• CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2.
  Pedersen AE, Lauritsen JP
  Scand J Immunol. 2009
  PubMed ID: 19522766
   
  
• Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients.
  Singh B, Bera NK, Nayak CR, Chaudhuri TK
  Cytokine. 2009
  PubMed ID: 19502081
   
  
• Hepatitis C virus and disrupted interferon signaling promote lymphoproliferation via type II CD95 and interleukins.
  Machida K, Tsukiyama-Kohara K, Sekiguch S, Seike E, Tóne S, Hayashi Y, Tobita Y, Kasama Y, Shimizu M, Takahashi H, Taya C, Yonekawa H, Tanaka N, Kohara M
  Gastroenterology. 2009
  PubMed ID: 19362089
   
  
• Effect of desensitization in solid organ transplant recipients depends on some cytokines genes polymorphism.
  Lobashevsky AL, Manwaring JE, Travis MM, Nord BL, Higgins NG, Serov YA, Arnoff TS, Hommel-Berrey GA, Goggins WC, Taber TE, Carter CB, Smith DS, Wozniak TC, O'Donnell JA, Turrentine MW
  Transpl Immunol. 2009
  PubMed ID: 19332120
   
  
• IL-2, IFN-gamma, and IL-12 Gene Polymorphisms and Susceptibility to Multiple Sclerosis.
  Ali Shokrgozar M, Sarial S, Amirzargar A, Shokri F, Rezaei N, Arjang Z, Radfar J, Yousefi-Behzadi M, Ali Sahraian M, Lotfi J
  J Clin Immunol. 2009
  PubMed ID: 19543959
   
  
• Involvement of CD252 (CD134L) and IL-2 in the expression of cytotoxic proteins in bacterial- or viral-activated human T cells.
  Walch M, Rampini SK, Stoeckli I, Latinovic-Golic S, Dumrese C, Sundstrom H, Vogetseder A, Marino J, Glauser DL, van den Broek M, Sander P, Groscurth P, Ziegler U
  J Immunol. 2009
  PubMed ID: 19494280
   
  
• Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women.
  Van Dyke AL, Cote ML, Wenzlaff AS, Chen W, Abrams J, Land S, Giroux CN, Schwartz AG
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19505916
   
  
• PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.
  Chikuma S, Terawaki S, Hayashi T, Nabeshima R, Yoshida T, Shibayama S, Okazaki T, Honjo T
  J Immunol. 2009
  PubMed ID: 19454662
   
  
• Interleukin-2 as a predictor of early postoperative atrial fibrillation after cardiopulmonary bypass graft (CABG).
  Hak Ł, Myśliwska J, Wieckiewicz J, Szyndler K, Siebert J, Rogowski J
  J Interferon Cytokine Res. 2009
  PubMed ID: 19450160
   
  
• Serum vascular endothelial growth factor and fibronectin predict clinical response to high-dose interleukin-2 therapy.
  Sabatino M, Kim-Schulze S, Panelli MC, Stroncek D, Wang E, Taback B, Kim DW, Deraffele G, Pos Z, Marincola FM, Kaufman HL
  J Clin Oncol. 2009
  PubMed ID: 19364969
   
  
• Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination.
  Ovsyannikova IG, Ryan JE, Vierkant RA, O'Byrne MM, Pankratz VS, Jacobson RM, Poland GA
  Vaccine. 2009
  PubMed ID: 19200845
   
  
• A programmed switch from IL-15- to IL-2-dependent activation in human NK cells.
  Pillet AH, Bugault F, Thèze J, Chakrabarti LA, Rose T
  J Immunol. 2009
  PubMed ID: 19414780
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis.
  Daha NA, Kurreeman FA, Marques RB, Stoeken-Rijsbergen G, Verduijn W, Huizinga TW, Toes RE
  Arthritis Rheum. 2009
  PubMed ID: 19404967
   
  
• Involvement of functional polymorphisms in the TNFA gene in the pathogenesis of autoimmune thyroid diseases and production of anti-thyrotropin receptor antibody.
  Inoue N, Watanabe M, Nanba T, Wada M, Akamizu T, Iwatani Y
  Clin Exp Immunol. 2009
  PubMed ID: 19250279
   
  
• Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
  Environ Mol Mutagen. 2009
  PubMed ID: 19170196
   
  
• Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylase.
  Nayak A, Glöckner-Pagel J, Vaeth M, Schumann JE, Buttmann M, Bopp T, Schmitt E, Serfling E, Berberich-Siebelt F
  J Biol Chem. 2009
  PubMed ID: 19218564
   
  
• Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection.
  Molloy MJ, Zhang W, Usherwood EJ
  J Immunol. 2009
  PubMed ID: 19342623
   
  
• TNF-alpha and IL-10 gene polymorphisms show a weak association with pemphigus vulgaris in the Slovak population.
  Javor J, Chmurova N, Parnicka Z, Ferencik S, Grosse-Wilde H, Buc M, Svecova D
  J Eur Acad Dermatol Venereol. 2009
  PubMed ID: 19470040
   
  
• [HBcAg-specific CTL response induced by PTD-HBcAg fusion protein to inhibit HBV replication in vitro]
  Chen XH, Pan QC, Yu YS, Tang ZH, Zang GQ
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
  PubMed ID: 19351491
   
  
• Comparison of IL10 and IL2 genotypes of Turkish population with other populations.
  Yazici AC, Atac FB, Verdi H, Ozbek N
  Int J Immunogenet. 2009
  PubMed ID: 19284443
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
  Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
  Pediatr Infect Dis J. 2009
  PubMed ID: 19258923
   
  
• Critical role of NOD2 in regulating the immune response to Staphylococcus aureus.
  Deshmukh HS, Hamburger JB, Ahn SH, McCafferty DG, Yang SR, Fowler VG
  Infect Immun. 2009
  PubMed ID: 19139201
   
  
• Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells.
  Dearman RJ, Cumberbatch M, Maxwell G, Basketter DA, Kimber I
  Immunology. 2009
  PubMed ID: 18778283
   
  
• Excessive ovarian response is associated with increased expression of interleukin-2 in the periimplantation endometrium.
  Makkar G, Ng EH, Yeung WS, Ho PC
  Fertil Steril. 2009
  PubMed ID: 18331736
   
  
• Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus.
  Wojciechowski W, Harris DP, Sprague F, Mousseau B, Makris M, Kusser K, Honjo T, Mohrs K, Mohrs M, Randall T, Lund FE
  Immunity. 2009
  PubMed ID: 19249230
   
  
• Phospholipase Cgamma2 is critical for Dectin-1-mediated Ca2+ flux and cytokine production in dendritic cells.
  Xu S, Huo J, Lee KG, Kurosaki T, Lam KP
  J Biol Chem. 2009
  PubMed ID: 19136564
   
  
• Association of cytokine gene polymorphisms with chronic obstructive pulmonary disease in Macedonians.
  Trajkov D, Mirkovska-Stojkovikj J, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Sandevska E, Sibinovska O, Hristomanova S, Djulejic E, Petrov J, Gogusev J, Spiroski M
  Iran J Allergy Asthma Immunol. 2009
  PubMed ID: 19279357
   
  
• Analysis of adhesion molecules, target cells, and role of IL-2 in human FOXP3+ regulatory T cell suppressor function.
  Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, Shevach EM
  J Immunol. 2009
  PubMed ID: 19234188
   
  
• Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population.
  Sata F, Toya S, Yamada H, Suzuki K, Saijo Y, Yamazaki A, Minakami H, Kishi R
  Mol Hum Reprod. 2009
  PubMed ID: 19141488
   
  
• A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production.
  Lardone PJ, Carrillo-Vico A, Molinero P, Rubio A, Guerrero JM
  Cell Mol Life Sci. 2009
  PubMed ID: 19099187
   
  
• IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12.
  van de Wetering D, de Paus RA, van Dissel JT, van de Vosse E
  Int Immunol. 2009
  PubMed ID: 19088061
   
  
• Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.
  Velez DR, Fortunato S, Thorsen P, Lombardi SJ, Williams SM, Menon R
  Am J Obstet Gynecol. 2009
  PubMed ID: 19019335
   
  
• IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes.
  Duré M, Macian F
  Mol Immunol. 2009
  PubMed ID: 18990450
   
  
• IFN-gamma reverses IL-2- and IL-4-mediated T-cell steroid resistance.
  Goleva E, Li LB, Leung DY
  Am J Respir Cell Mol Biol. 2009
  PubMed ID: 18776133
   
  
• CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses.
  Verma ND, Plain KM, Nomura M, Tran GT, Robinson C, Boyd R, Hodgkinson SJ, Hall BM
  Blood. 2009
  PubMed ID: 18827184
   
  
• Distinct roles of helper T-cell subsets in a systemic autoimmune disease.
  Hoyer KK, Kuswanto WF, Gallo E, Abbas AK
  Blood. 2009
  PubMed ID: 18815283
   
  
• Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of United States.
  Ognjanovic S, Yuan JM, Chaptman A, Fan Y, Yu MC
  Carcinogenesis. 2009
  PubMed ID: 19126646
   
  
• TOM1L is involved in a novel signaling pathway important for the IL-2 production in Jurkat T cells stimulated by CD3/CD28 co-ligation.
  Elmarghani A, Abuabaid H, Kjellen P
  Mediators Inflamm. 2009
  PubMed ID: 20182632
   
  
• IL-2 regulates SEB induced toxic shock syndrome in BALB/c mice.
  Khan AA, Priya S, Saha B
  PLoS One. 2009
  PubMed ID: 20041187
   
  
• Eosinophil and T cell markers predict functional decline in COPD patients.
  D'Armiento JM, Scharf SM, Roth MD, Connett JE, Ghio A, Sternberg D, Goldin JG, Louis TA, Mao JT, O'Connor GT, Ramsdell JW, Ries AL, Schluger NW, Sciurba FC, Skeans MA, Voelker H, Walter RE, Wendt CH, Weinmann GG, Wise RA, Foronjy RF
  Respir Res. 2009
  PubMed ID: 19925666
   
  
• CD4+ T cell-derived IL-2 signals during early priming advances primary CD8+ T cell responses.
  Lai YP, Lin CC, Liao WJ, Tang CY, Chen SC
  PLoS One. 2009
  PubMed ID: 19901991
   
  
• Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study.
  Gallo J, Mrazek F, Petrek M
  BMC Med Genet. 2009
  PubMed ID: 19860911
   
  
• If Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.
  Menon R, Pearce B, Velez DR, Merialdi M, Williams SM, Fortunato SJ, Thorsen P
  Reprod Biol Endocrinol. 2009
  PubMed ID: 19527514
   
  
• Distribution of the 22 cytokine gene polymorphisms in healthy Macedonian population.
  Trajkov D, Arsov T, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Gogusev J, Spiroski M
  Bratisl Lek Listy. 2009
  PubMed ID: 19408823
   
  
• Cytokine gene polymorphisms in common variable immunodeficiency.
  Rezaei N, Aghamohammadi A, Shakiba Y, Mahmoudi M, Jalali A, Moradi B, Amirzargar AA
  Int Arch Allergy Immunol. 2009
  PubMed ID: 19339796
   
  
• Testing for the association of the KIAA1109/Tenr/IL2/IL21 gene region with rheumatoid arthritis in a European family-based study.
  Teixeira VH, Pierlot C, Migliorini P, Balsa A, Westhovens R, Barrera P, Alves H, Vaz C, Fernandes M, Pascual-Salcedo D, Bombardieri S, Dequeker J, Radstake TR, Van Riel P, van de Putte L, Lopes-Vaz A, Bardin T, Prum B, Cornélis F, Petit-Teixeira E, European Consortium on Rheumatoid Arthritis Families
  Arthritis Res Ther. 2009
  PubMed ID: 19302705
   
  
• Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
  Bishop KD, Harris JE, Mordes JP, Greiner DL, Rossini AA, Czech MP, Phillips NE
  Cell Immunol. 2009
  PubMed ID: 19230866
   
  
• CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation.
  Camargo JF, Quinones MP, Mummidi S, Srinivas S, Gaitan AA, Begum K, Jimenez F, VanCompernolle S, Unutmaz D, Ahuja SS, Ahuja SK
  J Immunol. 2009
  PubMed ID: 19109148
   
  
• Increase of CD4+TNF{alpha}+IL-2-T cells in cerebrospinal fluid of multiple sclerosis patients.
  Shi N, Kawano Y, Matsuoka T, Mei F, Ishizu T, Ohyagi Y, Kira J
  Mult Scler. 2009
  PubMed ID: 18755820
   
  
• Cytokine gene polymorphisms and BALF cytokine levels in interstitial lung diseases.
  Vasakova M, Sterclova M, Kolesar L, Slavcev A, Pohunek P, Sulc J, Striz I
  Respir Med. 2008
  PubMed ID: 19117745
   
  
• Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner.
  Jiang G, Yang HR, Wang L, Wildey GM, Fung J, Qian S, Lu L
  Transplantation. 2008
  PubMed ID: 19077880
   
  
• Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil.
  Franceschi DS, Mazini PS, Rudnick CC, Sell AM, Tsuneto LT, Ribas ML, Peixoto PR, Visentainer JE
  Int J Infect Dis. 2008
  PubMed ID: 19058987
   
  
• Promoter polymorphisms of IL2, IL4, and risk of gastric cancer in a high-risk Chinese population.
  Wu J, Lu Y, Ding YB, Ke Q, Hu ZB, Yan ZG, Xue Y, Zhou Y, Hua ZL, Shu YQ, Liu P, Shen J, Xu YC, Shen HB
  Mol Carcinog. 2008
  PubMed ID: 19058298
   
  
• Association of pro/anti-inflammatory cytokine gene variants in renal transplant patients with allograft outcome and cyclosporine immunosuppressant levels.
  Manchanda PK, Kumar A, Sharma RK, Goel H, Mittal RD
  Biologics. 2008
  PubMed ID: 19707465
   
  
• [Correlation of polymorphisms of interleukin-2 gene and HBV DNA copies in patients with chronic hepatitis B]
  Wei YS, Lan Y, Yuan XH
  Zhonghua Gan Zang Bing Za Zhi. 2008
  PubMed ID: 19105930
   
  
• Cutting edge: CD4+ T cell-derived IL-2 is essential for help-dependent primary CD8+ T cell responses.
  Wilson EB, Livingstone AM
  J Immunol. 2008
  PubMed ID: 19017930
   
  
• Regulation of IL-2 expression by transcription factor BACH2 in umbilical cord blood CD4+ T cells.
  Lesniewski ML, Haviernik P, Weitzel RP, Kadereit S, Kozik MM, Fanning LR, Yang YC, Hegerfeldt Y, Finney MR, Ratajczak MZ, Greco N, Paul P, Maciejewski J, Laughlin MJ
  Leukemia. 2008
  PubMed ID: 18769450
   
  
• IL-10, TGF-beta, IL-2, IL-12, and IFN-gamma cytokine gene polymorphisms in asthma.
  Movahedi M, Mahdaviani SA, Rezaei N, Moradi B, Dorkhosh S, Amirzargar AA
  J Asthma. 2008
  PubMed ID: 18972297
   
  
• Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers.
  Shibata K, Yamada H, Nakamura R, Sun X, Itsumi M, Yoshikai Y
  J Immunol. 2008
  PubMed ID: 18941182
   
  
• Epstein-Barr virus nuclear antigen-1 renders lymphocytes responsive to IL-2 but not IL-15 for survival.
  Tsimbouri P, Al-Sheikh Y, Drotar ME, Cushley W, Wilson JB
  J Gen Virol. 2008
  PubMed ID: 18931080
   
  
• Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.
  Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ
  Nat Immunol. 2008
  PubMed ID: 18820682
   
  
• IL-2 family of cytokines in T regulatory cell development and homeostasis.
  Malek TR, Yu A, Zhu L, Matsutani T, Adeegbe D, Bayer AL
  J Clin Immunol. 2008
  PubMed ID: 18726679
   
  
• Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis.
  Queiroz DM, Oliveira AG, Saraiva IE, Rocha GA, Rocha AM, das Graças Pimenta Sanna M, Guerra JB, Dani R, de Lourdes Abreu Ferrari M, Castro LP
  Inflamm Bowel Dis. 2008
  PubMed ID: 18942754
   
  
• Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma.
  Su K, Chen F, Yan WM, Zeng QL, Xu L, Xi D, Pi B, Luo XP, Ning Q
  World J Gastroenterol. 2008
  PubMed ID: 18932275
   
  
• Blimp-1 induced by IL-4 plays a critical role in suppressing IL-2 production in activated CD4 T cells.
  Wang L, van Panhuys N, Hu-Li J, Kim S, Le Gros G, Min B
  J Immunol. 2008
  PubMed ID: 18832679
   
  
• Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
  Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
  Carcinogenesis. 2008
  PubMed ID: 18676680
   
  
• G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan.
  Lin YJ, Wan L, Sheu JJ, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin WY, Liu HP, Lin TH, Huang YM, Tsai FJ
  Clin Immunol. 2008
  PubMed ID: 18650128
   
  
• Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
  Habermann TM, Wang SS, Maurer MJ, Morton LM, Lynch CF, Ansell SM, Hartge P, Severson RK, Rothman N, Davis S, Geyer SM, Cozen W, Chanock SJ, Cerhan JR
  Blood. 2008
  PubMed ID: 18633131
   
  
• Serum cytokine and T regulatory cell levels in patients with burning mouth syndrome.
  Pekiner FN, Demirel GY, Gümrü B, Ozbayrak S
  J Oral Pathol Med. 2008
  PubMed ID: 18624934
   
  
• Six new celiac disease loci replicated in an Italian population confirm association to celiac disease.
  Romanos J, Barisani D, Trynka G, Zhernakova A, Bardella MT, Wijmenga C
  J Med Genet. 2008
  PubMed ID: 18805825
   
  
• The production of IL-10 by human regulatory T cells is enhanced by IL-2 through a STAT5-responsive intronic enhancer in the IL-10 locus.
  Tsuji-Takayama K, Suzuki M, Yamamoto M, Harashima A, Okochi A, Otani T, Inoue T, Sugimoto A, Toraya T, Takeuchi M, Yamasaki F, Nakamura S, Kibata M
  J Immunol. 2008
  PubMed ID: 18768844
   
  
• A new genetic variant involved in genetic susceptibility to alcoholic liver cirrhosis: -330T>G polymorphism of the interleukin-2 gene.
  Marcos M, Pastor I, González-Sarmiento R, Laso FJ
  Eur J Gastroenterol Hepatol. 2008
  PubMed ID: 18794598
   
  
• Association of cytokine gene polymorphisms with bronchial asthma in Macedonians.
  Trajkov D, Mirkovska-Stojkovikj J, Arsov T, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Sandevska E, Gogusev J, Spiroski M
  Iran J Allergy Asthma Immunol. 2008
  PubMed ID: 18780949
   
  
• Correlation between genetic polymorphism of cytokine genes, plasma protein levels and bronchial asthma in the Han people in northern China.
  Xiaomin L, Fenglin C, Jianmin H, Yuzhi S, Binsheng G, Yingmei Z
  J Asthma. 2008
  PubMed ID: 18773331
   
  
• Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival.
  Martins GA, Cimmino L, Liao J, Magnusdottir E, Calame K
  J Exp Med. 2008
  PubMed ID: 18725523
   
  
• Th2 cell therapy of established acute graft-versus-host disease requires IL-4 and IL-10 and is abrogated by IL-2 or host-type antigen-presenting cells.
  Foley JE, Mariotti J, Ryan K, Eckhaus M, Fowler DH
  Biol Blood Marrow Transplant. 2008
  PubMed ID: 18721759
   
  
• IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells.
  Litjens NH, Huisman M, Hijdra D, Lambrecht BM, Stittelaar KJ, Betjes MG
  J Immunol. 2008
  PubMed ID: 18714042
   
  
• IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
  Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
  J Immunol. 2008
  PubMed ID: 18714000
   
  
• Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection.
  Noone CM, Paget E, Lewis EA, Loetscher MR, Newman RW, Johnson PA
  J Virol. 2008
  PubMed ID: 18614637
   
  
• Polymorphisms of interleukin-1 and interleukin-2 genes in patients with gastric cancer in Korea.
  Shin WG, Jang JS, Kim HS, Kim SJ, Kim KH, Jang MK, Lee JH, Kim HJ, Kim HY
  J Gastroenterol Hepatol. 2008
  PubMed ID: 18761558
   
  
• Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain.
  Lee YT, Wang WF, Cheng CW, Wu SL, Pawlak CR, Ho YJ
  Neuroreport. 2008
  PubMed ID: 18628674
   
  
• EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2.
  Lünemann JD, Jelcić I, Roberts S, Lutterotti A, Tackenberg B, Martin R, Münz C
  J Exp Med. 2008
  PubMed ID: 18663124
   
  
• The targeted immunocytokine L19-IL2 efficiently inhibits the growth of orthotopic pancreatic cancer.
  Wagner K, Schulz P, Scholz A, Wiedenmann B, Menrad A
  Clin Cancer Res. 2008
  PubMed ID: 18676770
   
  
• A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
  Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF
  Immunity. 2008
  PubMed ID: 18674934
   
  
• Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.
  Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL
  Science. 2008
  PubMed ID: 18635804
   
  
• Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure.
  McKarns SC, Schwartz RH
  J Immunol. 2008
  PubMed ID: 18606681
   
  
• Ability of epistatic interactions of cytokine single-nucleotide polymorphisms to predict susceptibility to disease subsets in systemic sclerosis patients.
  Beretta L, Cappiello F, Moore JH, Barili M, Greene CS, Scorza R
  Arthritis Rheum. 2008
  PubMed ID: 18576303
   
  
• Cervical and vulvar cancer risk in relation to the joint effects of cigarette smoking and genetic variation in interleukin 2.
  Hussain SK, Madeleine MM, Johnson LG, Du Q, Malkki M, Wilkerson HW, Farin FM, Carter JJ, Galloway DA, Daling JR, Petersdorf EW, Schwartz SM
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 18628433
   
  
• Polymorphisms in CLEC16A and CIITA at 16p13 are associated with primary adrenal insufficiency.
  Skinningsrud B, Husebye ES, Pearce SH, McDonald DO, Brandal K, Bøe Wolff A, Løvås K, Egeland T, Undlien DE
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18593762
   
  
• A heat shock protein gene (Hsp70.1) is critically involved in the generation of the immune response to myelin antigen.
  Mycko MP, Cwiklinska H, Walczak A, Libert C, Raine CS, Selmaj KW
  Eur J Immunol. 2008
  PubMed ID: 18581325
   
  
• The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases.
  Meylan F, Davidson TS, Kahle E, Kinder M, Acharya K, Jankovic D, Bundoc V, Hodges M, Shevach EM, Keane-Myers A, Wang EC, Siegel RM
  Immunity. 2008
  PubMed ID: 18571443
   
  
• Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis.
  Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Nisha Rajeswari D, Narayanan PR
  Cytokine. 2008
  PubMed ID: 18522869
   
  
• CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression.
  Matter MS, Claus C, Ochsenbein AF
  Eur J Immunol. 2008
  PubMed ID: 18506879
   
  
• The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse.
  Huang Y, Comiskey EO, Dupree RS, Li S, Koleske AJ, Burkhardt JK
  Blood. 2008
  PubMed ID: 18305217
   
  
• Association study of interleukin 2 (IL2) and IL4 with schizophrenia in a Japanese population.
  Watanabe Y, Nunokawa A, Shibuya M, Kaneko N, Nawa H, Someya T
  Eur Arch Psychiatry Clin Neurosci. 2008
  PubMed ID: 18574615
   
  
• T-cell development and function are modulated by dual specificity phosphatase DUSP5.
  Kovanen PE, Bernard J, Al-Shami A, Liu C, Bollenbacher-Reilley J, Young L, Pise-Masison C, Spolski R, Leonard WJ
  J Biol Chem. 2008
  PubMed ID: 18430737
   
  
• Cytokine single nucleotide polymorphisms in Iranian populations.
  Amirzargar AA, Naroueynejad M, Khosravi F, Dianat S, Rezaei N, Mytilineos J, Nikbin B
  Eur Cytokine Netw. 2008
  PubMed ID: 18632425
   
  
• [The association of IL-2 promoter polymorphisms with idiopathic dilated cardiomyopathy in Chinese Han population]
  Huang P, Zhou B, Zhang L, Liu X, Chen B, Rao L
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008
  PubMed ID: 18543227
   
  
• Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15.
  Yang CH, Tian L, Ling GS, Trendell-Smith NJ, Ma L, Lo CK, Stott DI, Liew FY, Huang FP
  Eur J Immunol. 2008
  PubMed ID: 18465774
   
  
• Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice.
  Kim S, Lalani S, Parekh VV, Vincent TL, Wu L, Van Kaer L
  J Clin Invest. 2008
  PubMed ID: 18451996
   
  
• A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells.
  Liu Y, Zhang P, Li J, Kulkarni AB, Perruche S, Chen W
  Nat Immunol. 2008
  PubMed ID: 18438410
   
  
• Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.
  Adamovic S, Amundsen SS, Lie BA, Gudjónsdóttir AH, Ascher H, Ek J, van Heel DA, Nilsson S, Sollid LM, Torinsson Naluai A
  Genes Immun. 2008
  PubMed ID: 18418394
   
  
• AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling.
  Missy K, Hu B, Schilling K, Harenberg A, Sakk V, Kuchenbecker K, Kutsche K, Fischer KD
  Mol Cell Biol. 2008
  PubMed ID: 18378701
   
  
• IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.
  Hinrichs CS, Spolski R, Paulos CM, Gattinoni L, Kerstann KW, Palmer DC, Klebanoff CA, Rosenberg SA, Leonard WJ, Restifo NP
  Blood. 2008
  PubMed ID: 18276844
   
  
• Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia.
  Ennas MG, Moore PS, Zucca M, Angelucci E, Cabras MG, Melis M, Gabbas A, Serpe R, Madeddu C, Scarpa A, Cocco P
  Hematol Oncol. 2008
  PubMed ID: 18271063
   
  
• Immunogenetic Correlates of Neisseria gonorrhoeae Infection in Adolescents.
  Geisler WM, Wang C, Tang J, Wilson CM, Crowley-Nowick PA, Kaslow RA
  Sex Transm Dis. 2008
  PubMed ID: 18496418
   
  
• Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
  Lindemann MJ, Hu Z, Benczik M, Liu KD, Gaffen SL
  J Biol Chem. 2008
  PubMed ID: 18348982
   
  
• [Implication of different expression of IL-2 mRNA and IL-10 mRNA in CD4(+)CD25(+)T cell induced immune tolerance of liver transplantation in rat]
  Shi LB, Zhang HW, Cui YY
  Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008
  PubMed ID: 18471351
   
  
• Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoimmunity.
  Waithman J, Gebhardt T, Davey GM, Heath WR, Carbone FR
  J Immunol. 2008
  PubMed ID: 18424696
   
  
• Potential role of phospholipase D2 in increasing interleukin-2 production by T-lymphocytes through activation of mitogen-activated protein kinases ERK1/ERK2.
  Hamdi SM, Cariven C, Coronas S, Malet N, Chap H, Perret B, Salles JP, Record M
  Biochim Biophys Acta. 2008
  PubMed ID: 18423386
   
  
• Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production.
  Sun GP, Wang H, Xu SP, Shen YX, Wu Q, Chen ZD, Wei W
  Eur J Pharmacol. 2008
  PubMed ID: 18329639
   
  
• Interleukin 21 enhances antibody-mediated tumor rejection.
  Smyth MJ, Teng MW, Sharkey J, Westwood JA, Haynes NM, Yagita H, Takeda K, Sivakumar PV, Kershaw MH
  Cancer Res. 2008
  PubMed ID: 18413772
   
  
• The lymphopenic environment of CD132 (common gamma-chain)-deficient hosts elicits rapid homeostatic proliferation of naive T cells via IL-15.
  Ramsey C, Rubinstein MP, Kim DM, Cho JH, Sprent J, Surh CD
  J Immunol. 2008
  PubMed ID: 18390713
   
  
• Dynamic changes of IL-2/IL-10, sFas and expression of Fas in intestinal mucosa in rats with acute necrotizing pancreatitis.
  Dang SC, Zhang JX, Qu JG, Mao ZF, Wang XQ, Zhu B
  World J Gastroenterol. 2008
  PubMed ID: 18407603
   
  
• IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8(+) T cell responses and increases the ratio of effector/memory CD8(+) T cells to regulatory T cells.
  Mostböck S, Lutsiak ME, Milenic DE, Baidoo K, Schlom J, Sabzevari H
  J Immunol. 2008
  PubMed ID: 18354238
   
  
• Brief antigenic stimulation generates effector CD8 T cells with low cytotoxic activity and high IL-2 production.
  Usharauli D, Kamala T
  J Immunol. 2008
  PubMed ID: 18354172
   
  
• Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage.
  Suzuki T, Yu HP, Hsieh YC, Choudhry MA, Bland KI, Chaudry IH
  Cytokine. 2008
  PubMed ID: 18343154
   
  
• Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice.
  Zheng L, Sharma R, Kung JT, Deshmukh US, Jarjour WN, Fu SM, Ju ST
  Int Immunol. 2008
  PubMed ID: 18310063
   
  
• Analysis of cytokine gene polymorphisms in recipient's matched with living donors on acute rejection after renal transplantation.
  Manchanda PK, Mittal RD
  Mol Cell Biochem. 2008
  PubMed ID: 18165865
   
  
• Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma.
  Cozen W, Gill PS, Salam MT, Nieters A, Masood R, Cockburn MG, Gauderman WJ, Martínez-Maza O, Nathwani BN, Pike MC, Van Den Berg DJ, Hamilton AS, Deapen DM, Mack TM
  Blood. 2008
  PubMed ID: 18077789
   
  
• Human IL-Rbeta chains form IL-2 binding homodimers.
  Pillet AH, Juffroy O, Mazard-Pasquier V, Moreau JL, Gesbert F, Chastagner P, Colle JH, Thèze J, Rose T
  Eur Cytokine Netw. 2008
  PubMed ID: 18299274
   
  
• Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.
  Barabanova SV, Artyukhina ZE, Ovchinnikova KT, Abramova TV, Kazakova TB, Khavinson VKh, Malinin VV, Korneva EA
  Neurosci Behav Physiol. 2008
  PubMed ID: 18264770
   
  
• Mutations in the zinc finger domain of IKK gamma block the activation of NF-kappa B and the induction of IL-2 in stimulated T lymphocytes.
  Shifera AS, Horwitz MS
  Mol Immunol. 2008
  PubMed ID: 18207244
   
  
• Gender dimorphism of tumor growth: role of gonadal hormones in differential regulation of apoptosis of a murine T cell lymphoma.
  Gupta V, Singh SM
  J Biomed Sci. 2008
  PubMed ID: 17965948
   
  
• Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy.
  Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, Baker B, Trocha A, Rosenberg R, Mackey E, Ueda P, Lu Z, Cohen D, Wrin T, Petropoulos CJ, Rosenberg ES, Walker BD
  J Infect Dis. 2008
  PubMed ID: 18275276
   
  
• Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS.
  Bae J, Park D, Lee YS, Jeoung D
  J Microbiol Biotechnol. 2008
  PubMed ID: 18309287
   
  
• The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease.
  Fukata M, Breglio K, Chen A, Vamadevan AS, Goo T, Hsu D, Conduah D, Xu R, Abreu MT
  J Immunol. 2008
  PubMed ID: 18209086
   
  
• TGF-beta inhibits IL-2 production and promotes cell cycle arrest in TCR-activated effector/memory T cells in the presence of sustained TCR signal transduction.
  Das L, Levine AD
  J Immunol. 2008
  PubMed ID: 18209044
   
  
• High expression of GADD-45alpha and VEGF induced tumor recurrence via upregulation of IL-2 after photodynamic therapy using NPe6.
  Ohtani K, Usuda J, Ichinose S, Ishizumi T, Hirata T, Inoue T, Maehara S, Imai K, Kubota M, Tsunoda Y, Yamada M, Tsutsui H, Yamada K, Kuroiwa Y, Furukawa K, Okunaka T, Kato H
  Int J Oncol. 2008
  PubMed ID: 18202762
   
  
• Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
  Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
  Rheumatology (Oxford). 2008
  PubMed ID: 18174230
   
  
• IL-27 inhibits the development of regulatory T cells via STAT3.
  Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M
  Int Immunol. 2008
  PubMed ID: 18156621
   
  
• Protein kinase C theta plays a fundamental role in different types of chronic colitis.
  Nagahama K, Ogawa A, Shirane K, Shimomura Y, Sugimoto K, Mizoguchi A
  Gastroenterology. 2008
  PubMed ID: 18155708
   
  
• Perlecan: a major IL-2-binding proteoglycan in murine spleen.
  Miller JD, Stevens ET, Smith DR, Wight TN, Wrenshall LE
  Immunol Cell Biol. 2008
  PubMed ID: 18040286
   
  
• IL-2 activation of STAT5 enhances production of IL-10 from human cytotoxic regulatory T cells, HOZOT.
  Tsuji-Takayama K, Suzuki M, Yamamoto M, Harashima A, Okochi A, Otani T, Inoue T, Sugimoto A, Motoda R, Yamasaki F, Nakamura S, Kibata M
  Exp Hematol. 2008
  PubMed ID: 18023521
   
  
• Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.
  Elias KM, Laurence A, Davidson TS, Stephens G, Kanno Y, Shevach EM, O'Shea JJ
  Blood. 2008
  PubMed ID: 17951529
   
  
• A chimera of interleukin 2 and a binding variant of aerolysin is selectively toxic to cells displaying the interleukin 2 receptor.
  Osusky M, Teschke L, Wang X, Wong K, Buckley JT
  J Biol Chem. 2008
  PubMed ID: 17981806
   
  
• Critical role for Rsk2 in T-lymphocyte activation.
  Lin JX, Spolski R, Leonard WJ
  Blood. 2008
  PubMed ID: 17938253
   
  
• A pro-inflammatory genotype predisposes to Barrett's esophagus.
  Moons LM, Kusters JG, van Delft JH, Kuipers EJ, Gottschalk R, Geldof H, Bode WA, Stoof J, van Vliet AH, Ketelslegers HB, Kleinjans JC, Siersema PD
  Carcinogenesis. 2008
  PubMed ID: 18192685
   
  
• Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
  Velez DR, Fortunato SJ, Thorsen P, Lombardi SJ, Williams SM, Menon R
  PLoS ONE. 2008
  PubMed ID: 18818748
   
  
• The association between cytokine gene polymorphisms and kidney allograft survival.
  Pawlik A, Domanski L, Rozanski J, Czerny B, Juzyszyn Z, Dutkiewicz G, Myslak M, Hałasa M, Słojewski M, Dabrowska-Zamojcin E
  Ann Transplant. 2008
  PubMed ID: 18566561
   
  
• Intestinal colonization of IL-2 deficient mice with non-colitogenic B. vulgatus prevents DC maturation and T-cell polarization.
  Müller M, Fink K, Geisel J, Kahl F, Jilge B, Reimann J, Mach N, Autenrieth IB, Frick JS
  PLoS ONE. 2008
  PubMed ID: 18545662
   
  
• Negative feedback regulation of T cells via interleukin-2 and FOXP3 reciprocity.
  Popmihajlov Z, Smith KA
  PLoS ONE. 2008
  PubMed ID: 18324310
   
  
• Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation.
  Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L
  J Immunol. 2008
  PubMed ID: 18097023
   
  
• IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells.
  Turka LA, Walsh PT
  Front Biosci. 2008
  PubMed ID: 17981641
   
  
• Hyaluronan synthesis is required for IL-2-mediated T cell proliferation.
  Mahaffey CL, Mummert ME
  J Immunol. 2007
  PubMed ID: 18056362
   
  
• A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms.
  Zheng L, Sharma R, Gaskin F, Fu SM, Ju ST
  J Immunol. 2007
  PubMed ID: 18056343
   
  
• Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors.
  Yamazaki S, Bonito AJ, Spisek R, Dhodapkar M, Inaba K, Steinman RM
  Blood. 2007
  PubMed ID: 17699744
   
  
• Characterization of mouse CD4 T cell subsets defined by expression of KLRG1.
  Beyersdorf N, Ding X, Tietze JK, Hanke T
  Eur J Immunol. 2007
  PubMed ID: 18034419
   
  
• IL2 and TNFA gene polymorphisms and the risk of graft-versus-host disease after allogeneic haematopoietic stem cell transplantation.
  Viel DO, Tsuneto LT, Sossai CR, Lieber SR, Marques SB, Vigorito AC, Aranha FJ, de Brito Eid KA, Oliveira GB, Miranda EC, de Souza CA, Visentainer JE
  Scand J Immunol. 2007
  PubMed ID: 18021367
   
  
• Ets-1 is a negative regulator of Th17 differentiation.
  Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho IC
  J Exp Med. 2007
  PubMed ID: 17967903
   
  
• [Genetic polymorphism of interleukin-2 gene in Chinese Han and Thai populations]
  Du B, Zhang L, Wei YS, Yang ZH, Zhou B, Zhang GQ
  Sichuan Da Xue Xue Bao Yi Xue Ban. 2007
  PubMed ID: 18095604
   
  
• Possible association of CTLA-4 gene polymorphism with cyclosporine-induced gingival overgrowth in kidney transplant recipients.
  Kusztal M, Radwan-Oczko M, Kościelska-Kasprzak K, Boratyńska M, Patrzałek D, Klinger M
  Transplant Proc. 2007
  PubMed ID: 18021981
   
  
• Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients: preliminary study.
  Satoh S, Saito M, Inoue K, Miura M, Komatsuda A, Habuchi T
  Int J Urol. 2007
  PubMed ID: 17956522
   
  
• Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate.
  Samy ET, Meyer CA, Caplazi P, Langrish CL, Lora JM, Bluethmann H, Peng SL
  J Immunol. 2007
  PubMed ID: 17947634
   
  
• Mechanism of HDAC inhibitor FR235222-mediated IL-2 transcriptional repression in Jurkat cells.
  Matsuoka H, Fujimura T, Mori H, Aramori I, Mutoh S
  Int Immunopharmacol. 2007
  PubMed ID: 17761346
   
  
• Human immunodeficiency virus type 1 controllers but not noncontrollers maintain CD4 T cells coexpressing three cytokines.
  Kannanganat S, Kapogiannis BG, Ibegbu C, Chennareddi L, Goepfert P, Robinson HL, Lennox J, Amara RR
  J Virol. 2007
  PubMed ID: 17728221
   
  
• Associations of IL-2 and IL-4 gene polymorphisms with psoriasis in the Korean population.
  Kim YK, Pyo CW, Choi HB, Kim SY, Kim TY, Kim TG
  J Dermatol Sci. 2007
  PubMed ID: 17714919
   
  
• CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells.
  Vosshenrich CA, Lesjean-Pottier S, Hasan M, Richard-Le Goff O, Corcuff E, Mandelboim O, Di Santo JP
  J Exp Med. 2007
  PubMed ID: 17923507
   
  
• Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin.
  Kumar N, Mishra J, Narang VS, Waters CM
  J Biol Chem. 2007
  PubMed ID: 17537734
   
  
• Interleukin (IL)-12, IL-2, interferon-gamma gene polymorphisms in subacute sclerosing panencephalitis patients.
  Yilmaz V, Demirbilek V, Gürses C, Yentür SP, Uysal S, Yapici Z, Yilmaz G, Muncey A, Cokar O, Onal E, Gökyiğit A, Saruhan-Direskeneli G
  J Neurovirol. 2007
  PubMed ID: 17994425
   
  
• Quantitative gene expression of cytokines in peripheral blood leukocytes stimulated in vitro: modulation by the anti-tumor nerosis factor-alpha antibody infliximab and comparison with the mucosal cytokine expression in patients with ulcerative colitis.
  Moriconi F, Raddatz D, Ho NA, Yeruva S, Dudas J, Ramadori G
  Transl Res. 2007
  PubMed ID: 17900510
   
  
• Superantigen-induced CD4+ T cell tolerance is associated with DNA methylation and histone hypo-acetylation at cytokine gene loci.
  Thomas RM, Saouaf SJ, Wells AD
  Genes Immun. 2007
  PubMed ID: 17671507
   
  
• Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40.
  Niedbala W, Cai B, Liu H, Pitman N, Chang L, Liew FY
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17875988
   
  
• Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
  Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
  J Infect Dis. 2007
  PubMed ID: 17703412
   
  
• Cascade of transcriptional induction and repression during IL-2 deprivation-induced apoptosis.
  Fleischer A, Duhamel M, Lopez-Fernandez LA, Muñoz M, Rebollo MP, Alvarez-Franco F, Rebollo A
  Immunol Lett. 2007
  PubMed ID: 17651815
   
  
• Rapid generation of a functional NK-cell compartment.
  Prlic M, Kamimura D, Bevan MJ
  Blood. 2007
  PubMed ID: 17554057
   
  
• Cytokine polymorphisms and risk of infection after kidney transplantation.
  Rodrigo E, Sánchez-Velasco P, Ruiz JC, Fernández-Fresnedo G, López-Hoyos M, Piñera C, Palomar R, Gómez-Alamillo C, González-Cotorruelo J, Leyba-Cobián F, Arias M
  Transplant Proc. 2007
  PubMed ID: 17889143
   
  
• Influence of interleukin-2 deficiency on the generation of autoimmune B cells.
  Wrenshall LE, Smith DR, Stevens ET, Miller JD
  J Autoimmun. 2007
  PubMed ID: 17692504
   
  
• Regulation of interleukin-2 signaling by fatty acids in human lymphocytes.
  Gorjão R, Hirabara SM, de Lima TM, Cury-Boaventura MF, Curi R
  J Lipid Res. 2007
  PubMed ID: 17592174
   
  
• Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population.
  Watt AP, Ross OA, Courtney J, Middleton D, Ennis M, Elborn JS
  J Cyst Fibros. 2007
  PubMed ID: 17336597
   
  
• An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
  Cho JH, Boyman O, Kim HO, Hahm B, Rubinstein MP, Ramsey C, Kim DM, Surh CD, Sprent J
  J Exp Med. 2007
  PubMed ID: 17664294
   
  
• Naive CD8+ T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo.
  Kamimura D, Bevan MJ
  J Exp Med. 2007
  PubMed ID: 17664293
   
  
• Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk.
  Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D
  J Exp Med. 2007
  PubMed ID: 17646407
   
  
• Cellular expression of interleukin 2 (IL-2) and its receptor (IL-2R, CD25) in lung tumours.
  Kasprzak A, Olejniczak K, Przybyszewska W, Zabel M
  Folia Morphol (Warsz). 2007
  PubMed ID: 17985312
   
  
• [Analgesic effect of interleukin-2 in mouse models of spared nerve injury]
  Liu S, Shi L, Wang JY, Fan GX, Yuan YK
  Nan Fang Yi Ke Da Xue Xue Bao. 2007
  PubMed ID: 17715020
   
  
• Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression.
  Kryczek I, Wei S, Vatan L, Escara-Wilke J, Szeliga W, Keller ET, Zou W
  J Immunol. 2007
  PubMed ID: 17641006
   
  
• Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population.
  Javor J, Bucova M, Ferencik S, Grosse-Wilde H, Buc M
  Int J Immunogenet. 2007
  PubMed ID: 17627763
   
  
• Intracellular cytokine patterns in Behçet's disease in comparison to ankylosing spondylitis--influence of treatment with interferon-alpha2a.
  Amberger M, Groll S, Günaydin I, Deuter C, Vonthein R, Kötter I
  Clin Exp Rheumatol. 2007
  PubMed ID: 17949552
   
  
• IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells.
  Amato R, Menniti M, Agosti V, Boito R, Costa N, Bond HM, Barbieri V, Tagliaferri P, Venuta S, Perrotti N
  J Mol Med. 2007
  PubMed ID: 17571248
   
  
• A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21.
  van Heel DA, Franke L, Hunt KA, Gwilliam R, Zhernakova A, Inouye M, Wapenaar MC, Barnardo MC, Bethel G, Holmes GK, Feighery C, Jewell D, Kelleher D, Kumar P, Travis S, Walters JR, Sanders DS, Howdle P, Swift J, Playford RJ, McLaren WM, Mearin ML, Mulder CJ, McManus R, McGinnis R, Cardon LR, Deloukas P, Wijmenga C
  Nat Genet. 2007
  PubMed ID: 17558408
   
  
• Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
  Cerhan JR, Wang S, Maurer MJ, Ansell SM, Geyer SM, Cozen W, Morton LM, Davis S, Severson RK, Rothman N, Lynch CF, Wacholder S, Chanock SJ, Habermann TM, Hartge P
  Blood. 2007
  PubMed ID: 17327408
   
  
• Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides.
  Naslednikova IO, Konenkov VI, Ryazantseva NV, Novitskii VV, Tkachenko SB, Zima AP, Avdoshina VV, Beloborodova EI, Beloborodova EV, Dortman VV
  Bull Exp Biol Med. 2007
  PubMed ID: 18239807
   
  
• Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis.
  Lee CC, Lin WY, Wan L, Tsai Y, Lin YJ, Tsai CH, Huang CM, Tsai FJ
  Immunogenetics. 2007
  PubMed ID: 17396252
   
  
• [Detection by flow cytometry of T cell subsets secreting IL-2 and UFNy(Gamma): optimalisation for the technic and the establishment of reference values]
  Kallel C, Masy E, Duthilleul P
  Pathol Biol (Paris). 2007
  PubMed ID: 16678358
   
  
• NF90 regulates inducible IL-2 gene expression in T cells.
  Shi L, Godfrey WR, Lin J, Zhao G, Kao PN
  J Exp Med. 2007
  PubMed ID: 17470640
   
  
• Expression of CXCR3 on mononuclear cells and CXCR3 ligands in patients with metastatic renal cell carcinoma in response to systemic IL-2 therapy.
  Reckamp KL, Figlin RA, Moldawer N, Pantuck AJ, Belldegrun AS, Burdick MD, Strieter RM
  J Immunother. 2007
  PubMed ID: 17457216
   
  
• Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis.
  Mattuzzi S, Barbi S, Carletto A, Ravagnani V, Moore PS, Bambara LM, Scarpa A
  J Rheumatol. 2007
  PubMed ID: 17444587
   
  
• Paradoxical effect of reduced costimulation in T cell-mediated colitis.
  Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M
  J Immunol. 2007
  PubMed ID: 17442938
   
  
• Elevated interleukin-4 expression in severe recurrent hepatitis C virus after liver transplantation.
  Dharancy S, Podevin P, Aoudjehane L, Batteux F, Rosenberg AR, Soubrane O, Calmus Y, Conti F
  Transplantation. 2007
  PubMed ID: 17460561
   
  
• Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells.
  Bayer AL, Yu A, Malek TR
  J Immunol. 2007
  PubMed ID: 17371960
   
  
• Characterization of the sequence and architectural constraints of the regulatory and core regions of the human interleukin-2 promoter.
  Weaver JR, Good K, Walters RD, Kugel JF, Goodrich JA
  Mol Immunol. 2007
  PubMed ID: 17337059
   
  
• Interleukin (IL)-12 receptor beta1 codon 378 G homozygote and allele, but not IL-1 (beta-511 promoter, 3953 exon 5, receptor antagonist), IL-2 114, IL-4-590 intron 3, IL-8 3'-UTR 2767, and IL-18 105, are associated with higher susceptibility to leiomyoma.
  Hsieh YY, Chang CC, Tsai CH, Lin CC, Tsai FJ
  Fertil Steril. 2007
  PubMed ID: 17222831
   
  
• Role of human neutrophil peptides in the initial interaction between lung epithelial cells and CD4+ lymphocytes.
  Vaschetto R, Grinstein J, Del Sorbo L, Khine AA, Voglis S, Tullis E, Slutsky AS, Zhang H
  J Leukoc Biol. 2007
  PubMed ID: 17215524
   
  
• Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells.
  Bandyopadhyay S, Duré M, Paroder M, Soto-Nieves N, Puga I, Macián F
  Blood. 2007
  PubMed ID: 17148585
   
  
• Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells.
  Dooms H, Wolslegel K, Lin P, Abbas AK
  J Exp Med. 2007
  PubMed ID: 17312008
   
  
• Profile of cytokine gene polymorphisms in Iranian multiple sclerosis patients.
  Amirzargar A, Khosravi F, Dianat S, Hushmand F, Maryousef P, Foroushani AR, Lotfi J, Nikbin B
  Mult Scler. 2007
  PubMed ID: 17439892
   
  
• Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation.
  Laurence A, Tato CM, Davidson TS, Kanno Y, Chen Z, Yao Z, Blank RB, Meylan F, Siegel R, Hennighausen L, Shevach EM, O'shea JJ
  Immunity. 2007
  PubMed ID: 17363300
   
  
• hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
  Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
  Genomics. 2007
  PubMed ID: 17207965
   
  
• IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
  Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
  J Immunol. 2007
  PubMed ID: 17277105
   
  
• Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells.
  Stopak KS, Chiu YL, Kropp J, Grant RM, Greene WC
  J Biol Chem. 2007
  PubMed ID: 17110377
   
  
• Maternal microchimerism leads to the presence of interleukin-2 in interleukin-2 knock out mice: implications for the role of interleukin-2 in thymic function.
  Wrenshall LE, Stevens ET, Smith DR, Miller JD
  Cell Immunol. 2007
  PubMed ID: 17524378
   
  
• CD4+ Th1 cells promote CD8+ Tc1 cell survival, memory response, tumor localization and therapy by targeted delivery of interleukin 2 via acquired pMHC I complexes.
  Huang H, Hao S, Li F, Ye Z, Yang J, Xiang J
  Immunology. 2007
  PubMed ID: 17274112
   
  
• Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population.
  Kaur G, Rapthap CC, Kumar N, Kumar S, Neolia S, Mehra NK
  Tissue Antigens. 2007
  PubMed ID: 17257312
   
  
• Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus.
  Kyttaris VC, Wang Y, Juang YT, Weinstein A, Tsokos GC
  J Immunol. 2007
  PubMed ID: 17237447
   
  
• Suppression of early IL-4 production underlies the failure of CD4 T cells activated by TLR-stimulated dendritic cells to differentiate into Th2 cells.
  Sun J, Pearce EJ
  J Immunol. 2007
  PubMed ID: 17237413
   
  
• Age-associated decline in effective immune synapse formation of CD4(+) T cells is reversed by vitamin E supplementation.
  Marko MG, Ahmed T, Bunnell SC, Wu D, Chung H, Huber BT, Meydani SN
  J Immunol. 2007
  PubMed ID: 17237392
   
  
• A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis.
  Sharma R, Zheng L, Deshmukh US, Jarjour WN, Sung SS, Fu SM, Ju ST
  J Immunol. 2007
  PubMed ID: 17237369
   
  
• Association of interleukin (IL)-4 intron-3 and IL-6 -174 G/C gene polymorphism with susceptibility to end-stage renal disease.
  Mittal RD, Manchanda PK
  Immunogenetics. 2007
  PubMed ID: 17203290
   
  
• T cells contribute to lysophosphatidylcholine-induced macrophage activation and demyelination in the CNS.
  Ghasemlou N, Jeong SY, Lacroix S, David S
  Glia. 2007
  PubMed ID: 17096403
   
  
• Carbohydrate consumption during cycling increases in vitro NK cell responses to IL-2 and IFN-gamma.
  McFarlin BK, Flynn MG, Hampton T
  Brain Behav Immun. 2007
  PubMed ID: 16889932
   
  
• Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.
  Villarino AV, Tato CM, Stumhofer JS, Yao Z, Cui YK, Hennighausen L, O'Shea JJ, Hunter CA
  J Exp Med. 2007
  PubMed ID: 17227909
   
  
• Disturbance of serum interleukin-2 and interleukin-8 levels in posttraumatic and non-posttraumatic stress disorder earthquake survivors in northern China.
  Song Y, Zhou D, Guan Z, Wang X
  Neuroimmunomodulation. 2007
  PubMed ID: 18073500
   
  
• Interleukin-2 induces the proliferation of mouse primordial germ cells in vitro.
  Eguizabal C, Boyano MD, Díez-Torre A, Andrade R, Andollo N, De Felici M, Aréchaga J
  Int J Dev Biol. 2007
  PubMed ID: 17939120
   
  
• IL-2, TNF-alpha, and leptin: local versus systemic concentrations in NSCLC patients.
  Carpagnano GE, Spanevello A, Curci C, Salerno F, Palladino GP, Resta O, Di Gioia G, Carpagnano F, Foschino Barbaro MP
  Oncol Res. 2007
  PubMed ID: 17913045
   
  
• Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).
  Gingras S, Pelletier S, Boyd K, Ihle JN
  PLoS ONE. 2007
  PubMed ID: 17726538
   
  
• IL-2-induced IL-9 production by allergen-specific human helper T-cell clones.
  Kajiyama Y, Umezu-Goto M, Kobayashi N, Takahashi K, Fukuchi Y, Mori A
  Int Arch Allergy Immunol. 2007
  PubMed ID: 17541281
   
  
• The effect of compound nutrients on stress-induced changes in serum IL-2, IL-6 and TNF-alpha levels in rats.
  Liu YL, Bi H, Chi SM, Fan R, Wang YM, Ma XL, Chen YM, Luo WJ, Pei JM, Chen JY
  Cytokine. 2007
  PubMed ID: 17433709
   
  
• Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
  Huang HY, Thuita L, Strickland P, Hoffman SC, Comstock GW, Helzlsouer KJ
  BMC Genet. 2007
  PubMed ID: 17355643
   
  
• IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.
  Burchill MA, Yang J, Vogtenhuber C, Blazar BR, Farrar MA
  J Immunol. 2007
  PubMed ID: 17182565
   
  
• Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production.
  Gong D, Malek TR
  J Immunol. 2007
  PubMed ID: 17182561
   
  
• Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity.
  Carrier Y, Yuan J, Kuchroo VK, Weiner HL
  J Immunol. 2007
  PubMed ID: 17182552
   
  
• Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.
  Dhiman N, Ovsyannikova IG, Cunningham JM, Vierkant RA, Kennedy RB, Pankratz VS, Poland GA, Jacobson RM
  J Infect Dis. 2007
  PubMed ID: 17152005
   
  
• Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer.
  Hou L, El-Omar EM, Chen J, Grillo P, Rabkin CS, Baccarelli A, Yeager M, Chanock SJ, Zatonski W, Sobin LH, Lissowska J, Fraumeni JF, Chow WH
  Carcinogenesis. 2007
  PubMed ID: 16885196
   
  
• Inhibition of AMP-activated protein kinase suppresses IL-2 expression through down-regulation of NF-AT and AP-1 activation in Jurkat T cells.
  Jhun BS, Lee JY, Oh YT, Lee JH, Choe W, Baik HH, Kim SS, Yoon KS, Ha J, Kang I
  Biochem Biophys Res Commun. 2006
  PubMed ID: 17097050
   
  
• Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.
  Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK
  J Exp Med. 2006
  PubMed ID: 17130300
   
  
• Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes.
  Eidenschenk C, Jouanguy E, Alcaïs A, Mention JJ, Pasquier B, Fleckenstein IM, Puel A, Gineau L, Carel JC, Vivier E, Le Deist F, Casanova JL
  J Immunol. 2006
  PubMed ID: 17142786
   
  
• Latent virus influences the generation and maintenance of CD8+ T cell memory.
  Sheridan BS, Khanna KM, Frank GM, Hendricks RL
  J Immunol. 2006
  PubMed ID: 17142732
   
  
• Cutting Edge: TCR-induced NAB2 enhances T cell function by coactivating IL-2 transcription.
  Collins S, Wolfraim LA, Drake CG, Horton MR, Powell JD
  J Immunol. 2006
  PubMed ID: 17142725
   
  
• Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.
  Sharma R, Zheng L, Guo X, Fu SM, Ju ST, Jarjour WN
  J Autoimmun. 2006
  PubMed ID: 17207605
   
  
• Paradoxical response to tacrolimus assessed by interleukin-2 gene expression.
  El-Safa EA, Fredericks S, MacPhee I, Holt DW, Johnston A
  Transplant Proc. 2006
  PubMed ID: 17175263
   
  
• The common gamma chain cytokines interleukin (IL)-2 and IL-7 indirectly modulate blood fluke development via effects on CD4+ T cells.
  Blank RB, Lamb EW, Tocheva AS, Crow ET, Lim KC, McKerrow JH, Davies SJ
  J Infect Dis. 2006
  PubMed ID: 17083048
   
  
• Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells.
  Irie A, Harada K, Tsukamoto H, Kim JR, Araki N, Nishimura Y
  Int Immunol. 2006
  PubMed ID: 17077180
   
  
• Genetic background influences Th cell differentiation by controlling the capacity for IL-2-induced IL-4 production by naive CD4+ T cells.
  Yagi J, Arimura Y, Takatori H, Nakajima H, Iwamoto I, Uchiyama T
  Int Immunol. 2006
  PubMed ID: 17035345
   
  
• Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.
  Zhu J, Jankovic D, Grinberg A, Guo L, Paul WE
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 17116877
   
  
• [Expression of recombinant plasmid of HIV-1 gp120 and IFN-gamma in E. coli and its immunoregulatory effect]
  Zhao G, Wu NP, Yao HP
  Zhejiang Da Xue Xue Bao Yi Xue Ban. 2006
  PubMed ID: 17177332
   
  
• Naive T-cell receptor transgenic T cells help memory B cells produce antibody.
  Duffy D, Yang CP, Heath A, Garside P, Bell EB
  Immunology. 2006
  PubMed ID: 17067314
   
  
• Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome.
  Chien JY, Hsueh PR, Cheng WC, Yu CJ, Yang PC
  Respirology. 2006
  PubMed ID: 17052299
   
  
• Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals.
  Bejon P, Keating S, Mwacharo J, Kai OK, Dunachie S, Walther M, Berthoud T, Lang T, Epstein J, Carucci D, Moris P, Cohen J, Gilbert SC, Peshu N, Marsh K, Hill AV
  Infect Immun. 2006
  PubMed ID: 16966412
   
  
• Interleukin 2 regulation following semi-allogeneic bone marrow transplantation in mice.
  Abdul-Hai A, Ben-Yehuda A, Galsky H, Slavin S, Or R
  Cancer Immunol Immunother. 2006
  PubMed ID: 16450143
   
  
• ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation.
  Rui L, Healy JI, Blasioli J, Goodnow CC
  J Immunol. 2006
  PubMed ID: 17015719
   
  
• Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells.
  Yu A, Malek TR
  J Immunol. 2006
  PubMed ID: 17015695
   
  
• DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
  French AR, Sjölin H, Kim S, Koka R, Yang L, Young DA, Cerboni C, Tomasello E, Ma A, Vivier E, Kärre K, Yokoyama WM
  J Immunol. 2006
  PubMed ID: 17015680
   
  
• BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes.
  Cismasiu VB, Ghanta S, Duque J, Albu DI, Chen HM, Kasturi R, Avram D
  Blood. 2006
  PubMed ID: 16809611
   
  
• Th-1 cytokines gene polymorphism in human brucellosis.
  Davoudi S, Amirzargar AA, Hajiabdolbaghi M, Rasoolinejad M, Soodbakhsh A, Jafari S, Piri H, Maleknejad P, Bagherian H, Madadi N, Nikbin B
  Int J Immunogenet. 2006
  PubMed ID: 16984280
   
  
• Polymorphisms in cytokine genes and risk of Helicobacter pylori infection among Jamaican children.
  Tseng FC, Brown EE, Maiese EM, Yeager M, Welch R, Gold BD, Owens M, Cranston B, Hanchard B, El-Omar E, Hisada M
  Helicobacter. 2006
  PubMed ID: 16961803
   
  
• Interleukin (IL)-12, IL-2, and IL-6 gene polymorphisms in Takayasu's arteritis from Turkey.
  Saruhan-Direskeneli G, Biçakçigil M, Yilmaz V, Kamali S, Aksu K, Fresko I, Akkoç N, Kiraz S, Ozer HT, Tunç E, Yücel E, Karaarslan Y, Uyar FA, Doganavşargil E, Inanc M, Direskeneli H, Rheumatology Education and Research Society Vasculitis Study Group
  Hum Immunol. 2006
  PubMed ID: 17002904
   
  
• CD8+ cytotoxic T-APC stimulate central memory CD8+ T cell responses via acquired peptide-MHC class I complexes and CD80 costimulation, and IL-2 secretion.
  Xia D, Hao S, Xiang J
  J Immunol. 2006
  PubMed ID: 16920933
   
  
• All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3.
  Engedal N, Gjevik T, Blomhoff R, Blomhoff HK
  J Immunol. 2006
  PubMed ID: 16920920
   
  
• Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX.
  Perchonock CE, Fernando MC, Quinn WJ, Nguyen CT, Sun J, Shapiro MJ, Shapiro VS
  Mol Cell Biol. 2006
  PubMed ID: 16880512
   
  
• Role of toll-like receptors in spontaneous commensal-dependent colitis.
  Rakoff-Nahoum S, Hao L, Medzhitov R
  Immunity. 2006
  PubMed ID: 16879997
   
  
• Cytokine gene polymorphisms can alter the effect of Bacillus Calmette-Guérin (BCG) immunotherapy.
  Basturk B, Yavascaoglu I, Oral B, Göral G, Oktay B
  Cytokine. 2006
  PubMed ID: 16938461
   
  
• Duration of CTL activation regulates IL-2 production required for autonomous clonal expansion.
  Spierings DC, Lemmens EE, Grewal K, Schoenberger SP, Green DR
  Eur J Immunol. 2006
  PubMed ID: 16791878
   
  
• Indexation as a novel mechanism of lymphocyte homeostasis: the number of CD4+CD25+ regulatory T cells is indexed to the number of IL-2-producing cells.
  Almeida AR, Zaragoza B, Freitas AA
  J Immunol. 2006
  PubMed ID: 16785514
   
  
• In vivo effects of sequential granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-2 (IL-2) on circulating dendritic cells (DC) in patients with surgically resected high risk cutaneous melanoma.
  Hasskamp JH, Elias EG, Zapas JL
  J Clin Immunol. 2006
  PubMed ID: 16783532
   
  
• The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.
  Chae WJ, Henegariu O, Lee SK, Bothwell AL
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16769892
   
  
• Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells.
  Williams MA, Tyznik AJ, Bevan MJ
  Nature. 2006
  PubMed ID: 16778891
   
  
• IL-2 is required for the activation of memory CD8+ T cells via antigen cross-presentation.
  Blachère NE, Morris HK, Braun D, Saklani H, Di Santo JP, Darnell RB, Albert ML
  J Immunol. 2006
  PubMed ID: 16751372
   
  
• Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance.
  Shimoda M, Mmanywa F, Joshi SK, Li T, Miyake K, Pihkala J, Abbas JA, Koni PA
  J Immunol. 2006
  PubMed ID: 16709807
   
  
• Use of cytokine polymorphisms and Epstein-Barr virus viral load to predict development of post-transplant lymphoproliferative disorder in paediatric liver transplant recipients.
  Lee TC, Savoldo B, Barshes NR, Rooney CM, Heslop HE, Gee AP, Caldwell Y, Scott JD, Goss JA
  Clin Transplant. 2006
  PubMed ID: 16824159
   
  
• Interleukin-2-dependent mechanisms of tolerance and immunity in vivo.
  Antony PA, Paulos CM, Ahmadzadeh M, Akpinarli A, Palmer DC, Sato N, Kaiser A, Hinrichs CS, Heinrichs C, Klebanoff CA, Tagaya Y, Restifo NP
  J Immunol. 2006
  PubMed ID: 16621991
   
  
• Conditional up-regulation of IL-2 production by p38 MAPK inactivation is mediated by increased Erk1/2 activity.
  Kogkopoulou O, Tzakos E, Mavrothalassitis G, Baldari CT, Paliogianni F, Young HA, Thyphronitis G
  J Leukoc Biol. 2006
  PubMed ID: 16478922
   
  
• Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation.
  Kreisberg JF, Yonemoto W, Greene WC
  J Exp Med. 2006
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• Engagement of CD28 outside of the immunological synapse results in up-regulation of IL-2 mRNA stability but not IL-2 transcription.
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• Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress.
  Barabanova SV, Artyukhina ZE, Kazakova TB, Khavinson VKh, Malinin VV, Korneva EA
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• Aggressive non-Hodgkin's lymphoma: concomitant evaluation of interleukin-2, soluble interleukin-2 receptor, interleukin-4, interleukin-6, interleukin-10 and correlation with outcome.
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  Leuk Lymphoma. 2006
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• Interleukin-2 in human milk: a potential modulator of lymphocyte development in the breastfed infant.
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• Influence of interleukin-2 and interferon-gamma in murine schistosomiasis.
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  Cytokine. 2006
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• Th1/Th2 cytokine gene polymorphisms in patients with idiopathic pulmonary fibrosis.
  Vasakova M, Striz I, Slavcev A, Jandova S, Kolesar L, Sulc J
  Tissue Antigens. 2006
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• Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.
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• IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3.
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• Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.
  Hoeve MA, Savage ND, de Boer T, Langenberg DM, de Waal Malefyt R, Ottenhoff TH, Verreck FA
  Eur J Immunol. 2006
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• T cells use two directionally distinct pathways for cytokine secretion.
  Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM
  Nat Immunol. 2006
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• IL-2 induction by simian immunodeficiency virus involves MAP kinase signaling but is independent of calcineurin/NF-AT activity.
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• IL-2 and IL-4 polymorphisms as candidate genes in schizophrenia.
  Schwarz MJ, Krönig H, Riedel M, Dehning S, Douhet A, Spellmann I, Ackenheil M, Möller HJ, Müller N
  Eur Arch Psychiatry Clin Neurosci. 2006
  PubMed ID: 16091861
   
  
• Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.
  Stauber DJ, Debler EW, Horton PA, Smith KA, Wilson IA
  Proc Natl Acad Sci U S A. 2006
  PubMed ID: 16477002
   
  
• Family based association analysis of the IL2 and IL15 genes in allergic disorders.
  Christensen U, Haagerup A, Binderup HG, Vestbo J, Kruse TA, Børglum AD
  Eur J Hum Genet. 2006
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• Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions.
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• TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.
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  Blood. 2006
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• IL-2 gene C/T polymorphism is associated with prostate cancer.
  Wu HC, Chang CH, Wan L, Wu CI, Tsai FJ, Chen WC
  J Clin Lab Anal. 2006
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• Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome.
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  Mediators Inflamm. 2006
  PubMed ID: 16864905
   
  
• Interleukin-2 (IL-2) expression in livers of patients with chronic hepatitis C virus (HCV) infection.
  Kasprzak A, Seidel J, Adamek A, Biczysko W, Wysocki J, Spachacz R, Juszczyk J, Zabel M
  Folia Histochem Cytobiol. 2006
  PubMed ID: 16805135
   
  
• Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
  Rothman N, Skibola CF, Wang SS, Morgan G, Lan Q, Smith MT, Spinelli JJ, Willett E, De Sanjose S, Cocco P, Berndt SI, Brennan P, Brooks-Wilson A, Wacholder S, Becker N, Hartge P, Zheng T, Roman E, Holly EA, Boffetta P, Armstrong B, Cozen W, Linet M, Bosch FX, Ennas MG, Holford TR, Gallagher RP, Rollinson S, Bracci PM, Cerhan JR, Whitby D, Moore PS, Leaderer B, Lai A, Spink C, Davis S, Bosch R, Scarpa A, Zhang Y, Severson RK, Yeager M, Chanock S, Nieters A
  Lancet Oncol. 2006
  PubMed ID: 16389181
   
  
• Behavioral risk exposure and host genetics of susceptibility to HIV-1 infection.
  Shrestha S, Strathdee SA, Galai N, Oleksyk T, Fallin MD, Mehta S, Schaid D, Vlahov D, O'Brien SJ, Smith MW
  J Infect Dis. 2006
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• IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation.
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• The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion.
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  PubMed ID: 16339532
   
  
• TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.
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  FEBS Lett. 2005
  PubMed ID: 16293250
   
  
• Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy.
  Scola L, Candore G, Colonna-Romano G, Crivello A, Forte GI, Paolisso G, Franceschi C, Lio D, Caruso C
  Biogerontology. 2005
  PubMed ID: 16518704
   
  
• Interleukin-2 and interleukin-6 gene promoter polymorphisms, and early failure of dental implants.
  Campos MI, Godoy dos Santos MC, Trevilatto PC, Scarel-Caminaga RM, Bezerra FJ, Line SR
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• Bone marrow-derived dendritic cells reverse the anergic state of CD4+CD25+ T cells without reversing their suppressive function.
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• Inducing and expanding regulatory T cell populations by foreign antigen.
  Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H
  Nat Immunol. 2005
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• Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway.
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  Mech Ageing Dev. 2005
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• Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
  Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK
  J Exp Med. 2005
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• Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
  Wang X, Rickert M, Garcia KC
  Science. 2005
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• The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.
  Shapiro MJ, Chen YY, Shapiro VS
  J Biol Chem. 2005
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• Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
  Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY
  Cell Res. 2005
  PubMed ID: 16354571
   
  
• Reduced expression of interleukin-2 decreases the frequency of alopecia areata onset in C3H/HeJ mice.
  Freyschmidt-Paul P, McElwee KJ, Hoffmann R, Sundberg JP, Kissling S, Hummel S, Vitacolonna M, Kopp-Schneider A, Zöller M
  J Invest Dermatol. 2005
  PubMed ID: 16297194
   
  
• A function for interleukin 2 in Foxp3-expressing regulatory T cells.
  Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY
  Nat Immunol. 2005
  PubMed ID: 16227984
   
  
• Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling.
  D'Cruz LM, Klein L
  Nat Immunol. 2005
  PubMed ID: 16227983
   
  
• Regulation of Rho signaling pathways in interleukin-2-stimulated human T-lymphocytes.
  Mzali R, Seguin L, Liot C, Auger A, Pacaud P, Loirand G, Thibault C, Pierre J, Bertoglio J
  FASEB J. 2005
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• Frequencies of the common promoter polymorphisms in cytokine genes in a Polish population.
  Kurzawski M, Pawlik A, Czerny B, Domański L, Rózański J, Droździk M
  Int J Immunogenet. 2005
  PubMed ID: 16164695
   
  
• IL-15 but not IL-2 rapidly induces lethal xenogeneic graft-versus-host disease.
  Roychowdhury S, Blaser BW, Freud AG, Katz K, Bhatt D, Ferketich AK, Bergdall V, Kusewitt D, Baiocchi RA, Caligiuri MA
  Blood. 2005
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• T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo.
  Webb AI, Dunstone MA, Williamson NA, Price JD, de Kauwe A, Chen W, Oakley A, Perlmutter P, McCluskey J, Aguilar MI, Rossjohn J, Purcell AW
  J Immunol. 2005
  PubMed ID: 16148127
   
  
• IL-2 induces expression and secretion of IFN-gamma in murine peritoneal macrophages.
  Puddu P, Carollo M, Pietraforte I, Spadaro F, Tombesi M, Ramoni C, Belardelli F, Gessani S
  J Leukoc Biol. 2005
  PubMed ID: 15951352
   
  
• Characterization of the murine immunological signaling network with phosphospecific flow cytometry.
  Krutzik PO, Hale MB, Nolan GP
  J Immunol. 2005
  PubMed ID: 16081807
   
  
• Coordinate analysis of murine immune cell surface markers and intracellular phosphoproteins by flow cytometry.
  Krutzik PO, Clutter MR, Nolan GP
  J Immunol. 2005
  PubMed ID: 16081806
   
  
• High-affinity CD25-binding IL-2 mutants potently stimulate persistent T cell growth.
  Rao BM, Driver I, Lauffenburger DA, Wittrup KD
  Biochemistry. 2005
  PubMed ID: 16060678
   
  
• Cytokine gene polymorphisms in population of ethnic Macedonians.
  Trajkov D, Arsov T, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Spiroski M
  Croat Med J. 2005
  PubMed ID: 16100774
   
  
• CD44v6 promotes proliferation by persisting activation of MAP kinases.
  Marhaba R, Bourouba M, Zöller M
  Cell Signal. 2005
  PubMed ID: 15894169
   
  
• 1H, 15N, and 13C resonance assignments of human interleukin-2.
  Fry DC, Emerson SD, Liu CM, Palermo R
  J Biomol NMR. 2005
  PubMed ID: 16132828
   
  
• Homeostatic role of interferons conferred by inhibition of IL-1-mediated inflammation and tissue destruction.
  Hu X, Ho HH, Lou O, Hidaka C, Ivashkiv LB
  J Immunol. 2005
  PubMed ID: 15972639
   
  
• Risk of spontaneous preterm birth is associated with common proinflammatory cytokine polymorphisms.
  Engel SA, Erichsen HC, Savitz DA, Thorp J, Chanock SJ, Olshan AF
  Epidemiology. 2005
  PubMed ID: 15951664
   
  
• AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells.
  Jhun BS, Oh YT, Lee JY, Kong Y, Yoon KS, Kim SS, Baik HH, Ha J, Kang I
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15910743
   
  
• Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo.
  Erdmann AA, Gao ZG, Jung U, Foley J, Borenstein T, Jacobson KA, Fowler DH
  Blood. 2005
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• Cytokine mRNA levels in brain and peripheral tissues of the rat: relationships with plus-maze behavior.
  Pawlak CR, Schwarting RK, Bauhofer A
  Brain Res Mol Brain Res. 2005
  PubMed ID: 15950774
   
  
• T-cell specific enhancement of histone H3 acetylation in 5' flanking region of the IL-2 gene.
  Wang L, Kametani Y, Katano I, Habu S
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15850801
   
  
• IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection.
  Pawlik A, Domanski L, Rozanski J, Florczak M, Dabrowska-Zamojcin E, Dutkiewicz G, Gawronska-Szklarz B
  Transplant Proc. 2005
  PubMed ID: 15964333
   
  
• Interleukin-2 gene polymorphisms associated with increased risk of gastric atrophy from Helicobacter pylori infection.
  Togawa S, Joh T, Itoh M, Katsuda N, Ito H, Matsuo K, Tajima K, Hamajima N
  Helicobacter. 2005
  PubMed ID: 15904474
   
  
• Arginine methylation regulates IL-2 gene expression: a role for protein arginine methyltransferase 5 (PRMT5).
  Richard S, Morel M, Cléroux P
  Biochem J. 2005
  PubMed ID: 15654770
   
  
• Preferential loss of IL-2-secreting CD4+ T helper cells in chronic HCV infection.
  Semmo N, Day CL, Ward SM, Lucas M, Harcourt G, Loughry A, Klenerman P
  Hepatology. 2005
  PubMed ID: 15841456
   
  
• Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice.
  Beck RD, Wasserfall C, Ha GK, Cushman JD, Huang Z, Atkinson MA, Petitto JM
  Brain Res. 2005
  PubMed ID: 15829231
   
  
• Signals from CD28 induce stable epigenetic modification of the IL-2 promoter.
  Thomas RM, Gao L, Wells AD
  J Immunol. 2005
  PubMed ID: 15814687
   
  
• Physiological relevance of antigen presentasome (APS), an acquired MHC/costimulatory complex, in the sustained activation of CD4+ T cells in the absence of APCs.
  Zhou J, Tagaya Y, Tolouei-Semnani R, Schlom J, Sabzevari H
  Blood. 2005
  PubMed ID: 15637136
   
  
• Systemic iron supplementation replenishes iron stores without enhancing colon carcinogenesis in murine models of ulcerative colitis: comparison with iron-enriched diet.
  Seril DN, Liao J, Yang CS, Yang GY
  Dig Dis Sci. 2005
  PubMed ID: 15844705
   
  
• Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.
  Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC
  J Clin Invest. 2005
  PubMed ID: 15841182
   
  
• Reduced susceptibility to dextran sulphate sodium-induced colitis in the interleukin-2 heterozygous (IL-2) mouse.
  Sund M, Xu LL, Rahman A, Qian BF, Hammarström ML, Danielsson A
  Immunology. 2005
  PubMed ID: 15804292
   
  
• Inducing P-selectin ligand formation in CD8 T cells: IL-2 and IL-12 are active in vitro but not required in vivo.
  Carlow DA, Williams MJ, Ziltener HJ
  J Immunol. 2005
  PubMed ID: 15778352
   
  
• A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, the TCR/CD3 complex, and IL-2 production in systemic lupus erythematosus T cells.
  Tsuzaka K, Setoyama Y, Yoshimoto K, Shiraishi K, Suzuki K, Abe T, Takeuchi T
  J Immunol. 2005
  PubMed ID: 15749888
   
  
• Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period.
  Bayer AL, Yu A, Adeegbe D, Malek TR
  J Exp Med. 2005
  PubMed ID: 15753210
   
  
• Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.
  Setoguchi R, Hori S, Takahashi T, Sakaguchi S
  J Exp Med. 2005
  PubMed ID: 15753206
   
  
• IL1beta+3953 exon 5 and IL-2 -330 promoter polymorphisms in patients with rheumatoid arthritis.
  Pawlik A, Kurzawski M, Florczak M, Gawronska Szklarz B, Herczyńska M
  Clin Exp Rheumatol. 2005
  PubMed ID: 15895884
   
  
• The cytokine gene polymorphisms in patients with chronic kidney graft rejection.
  Pawlik A, Domanski L, Rozanski J, Florczak M, Wrzesniewska J, Dutkiewicz G, Dabrowska-Zamojcin E, Gawronska-Szklarz B
  Transpl Immunol. 2005
  PubMed ID: 15814282
   
  
• Genetic variations in IL6 associate with intervertebral disc disease characterized by sciatica.
  Noponen-Hietala N, Virtanen I, Karttunen R, Schwenke S, Jakkula E, Li H, Merikivi R, Barral S, Ott J, Karppinen J, Ala-Kokko L
  Pain. 2005
  PubMed ID: 15733644
   
  
• Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.
  Rodriguez-Galán MC, Bream JH, Farr A, Young HA
  J Immunol. 2005
  PubMed ID: 15728489
   
  
• CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
  Antony PA, Piccirillo CA, Akpinarli A, Finkelstein SE, Speiss PJ, Surman DR, Palmer DC, Chan CC, Klebanoff CA, Overwijk WW, Rosenberg SA, Restifo NP
  J Immunol. 2005
  PubMed ID: 15728465
   
  
• IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: relation to development and neurotrophins.
  Beck RD, King MA, Ha GK, Cushman JD, Huang Z, Petitto JM
  J Neuroimmunol. 2005
  PubMed ID: 15710467
   
  
• IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites.
  Liu Z, Liu Q, Hamed H, Anthony RM, Foster A, Finkelman FD, Urban JF, Gause WC
  J Immunol. 2005
  PubMed ID: 15699158
   
  
• Rhox: a new homeobox gene cluster.
  Maclean JA, Chen MA, Wayne CM, Bruce SR, Rao M, Meistrich ML, Macleod C, Wilkinson MF
  Cell. 2005
  PubMed ID: 15707895
   
  
• Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.
  Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC
  J Biol Chem. 2005
  PubMed ID: 15563472
   
  
• Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells.
  Konstantinidis KV, Alici E, Aints A, Christensson B, Ljunggren HG, Dilber MS
  Exp Hematol. 2005
  PubMed ID: 15676209
   
  
• Roles for common cytokine receptor gamma-chain-dependent cytokines in the generation, differentiation, and maturation of NK cell precursors and peripheral NK cells in vivo.
  Vosshenrich CA, Ranson T, Samson SI, Corcuff E, Colucci F, Rosmaraki EE, Di Santo JP
  J Immunol. 2005
  PubMed ID: 15661875
   
  
• CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.
  Tai X, Cowan M, Feigenbaum L, Singer A
  Nat Immunol. 2005
  PubMed ID: 15640801
   
  
• Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system.
  Carrillo-Vico A, Lardone PJ, Fernández-Santos JM, Martín-Lacave I, Calvo JR, Karasek M, Guerrero JM
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15562014
   
  
• Dendritic cell-derived IL-2 production is regulated by IL-15 in humans and in mice.
  Feau S, Facchinetti V, Granucci F, Citterio S, Jarrossay D, Seresini S, Protti MP, Lanzavecchia A, Ricciardi-Castagnoli P
  Blood. 2005
  PubMed ID: 15353479
   
  
• Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells.
  Adachi S, Rothenberg EV
  Nucleic Acids Res. 2005
  PubMed ID: 15937196
   
  
• Nef: "necessary and enforcing factor" in HIV infection.
  Joseph AM, Kumar M, Mitra D
  Curr HIV Res. 2005
  PubMed ID: 15638726
   
  
• IL-2 overcomes the unresponsiveness but fails to reverse the regulatory function of antigen-induced T regulatory cells.
  Anderson PO, Sundstedt A, Yazici Z, Minaee S, O'Neill EJ, Woolf R, Nicolson K, Whitley N, Li L, Li S, Wraith DC, Wang P
  J Immunol. 2005
  PubMed ID: 15611254
   
  
• Apoptotic death of infiltrating cells in human cardiac allografts is regulated by IL-2, FASL, and FLIP.
  de Groot-Kruseman HA, Baan CC, Zondervan PE, de Weger RA, Niesters HG, Balk AH, Weimar W
  Transplant Proc. 2004
  PubMed ID: 15686714
   
  
• Signaling pathways in Th2 development.
  Mowen KA, Glimcher LH
  Immunol Rev. 2004
  PubMed ID: 15546395
   
  
• Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells.
  Fehérvári Z, Sakaguchi S
  Int Immunol. 2004
  PubMed ID: 15520045
   
  
• Interleukin (IL)-15 and IL-2 reciprocally regulate expression of the chemokine receptor CX3CR1 through selective NFAT1- and NFAT2-dependent mechanisms.
  Barlic J, McDermott DH, Merrell MN, Gonzales J, Via LE, Murphy PM
  J Biol Chem. 2004
  PubMed ID: 15347678
   
  
• B-Raf contributes to sustained extracellular signal-regulated kinase activation associated with interleukin-2 production stimulated through the T cell receptor.
  Tsukamoto H, Irie A, Nishimura Y
  J Biol Chem. 2004
  PubMed ID: 15339934
   
  
• In vitro IL-2 incubation induces CD69 expression and other phenotypic changes on NK subpopulations present in PBPC collections.
  Baptista MJ, Barbosa IL, Roncon S, Vaz CP, Campilho F, Campos A, Pimentel P, Carvalhais A
  Exp Hematol. 2004
  PubMed ID: 15539078
   
  
• Shock waves increase T-cell proliferation or IL-2 expression by activating p38 MAP kinase.
  Yu TC, Liu Y, Tan Y, Jiang Y, Zheng X, Xu X
  Acta Biochim Biophys Sin (Shanghai). 2004
  PubMed ID: 15514847
   
  
• Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
  Hwang KW, Sweatt WB, Mashayekhi M, Palucki DA, Sattar H, Chuang E, Alegre ML
  J Immunol. 2004
  PubMed ID: 15494488
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Donor genomics influence graft events: the effect of donor polymorphisms on acute rejection and chronic allograft nephropathy.
  Hoffmann S, Park J, Jacobson LM, Muehrer RJ, Lorentzen D, Kleiner D, Becker YT, Hullett DA, Mannon R, Kirk AD, Becker BN
  Kidney Int. 2004
  PubMed ID: 15458467
   
  
• Cytokine gene polymorphisms in Taiwan.
  Trejaut JA, Tsai ZU, Lee HL, Chen ZX, Lin M
  Tissue Antigens. 2004
  PubMed ID: 15361128
   
  
• The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectin.
  Alcaide P, Fresno M
  Int Immunol. 2004
  PubMed ID: 15314038
   
  
• A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2.
  Bream JH, Hodge DL, Gonsky R, Spolski R, Leonard WJ, Krebs S, Targan S, Morinobu A, O'Shea JJ, Young HA
  J Biol Chem. 2004
  PubMed ID: 15271977
   
  
• A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis.
  Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR
  Cell. 2004
  PubMed ID: 15339668
   
  
• Interleukin-2 is essential for CD4+CD25+ regulatory T cell function.
  de la Rosa M, Rutz S, Dorninger H, Scheffold A
  Eur J Immunol. 2004
  PubMed ID: 15307180
   
  
• Selective cytoplasmic translocation of HuR and site-specific binding to the interleukin-2 mRNA are not sufficient for CD28-mediated stabilization of the mRNA.
  Seko Y, Azmi H, Fariss R, Ragheb JA
  J Biol Chem. 2004
  PubMed ID: 15020598
   
  
• Translocation of CD28 to lipid rafts and costimulation of IL-2.
  Sadra A, Cinek T, Imboden JB
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15280538
   
  
• Transfection of IL-2 and/or IL-12 genes into spleen in treatment of rat liver cancer.
  You TG, Wang HS, Yang JH, Qian QJ, Fan RF, Wu MC
  World J Gastroenterol. 2004
  PubMed ID: 15259063
   
  
• Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect.
  Gismondi A, Cifaldi L, Mazza C, Giliani S, Parolini S, Morrone S, Jacobelli J, Bandiera E, Notarangelo L, Santoni A
  Blood. 2004
  PubMed ID: 15001467
   
  
• Interleukin-2, but not interleukin-15, is required to terminate experimentally induced clonal T-cell anergy.
  Bendiksen S, Rekvig OP
  Scand J Immunol. 2004
  PubMed ID: 15238074
   
  
• Identification of an I-Ed-restricted T-cell epitope of Escherichia coli outer membrane protein F.
  Williams KM, Bigley EC
  Infect Immun. 2004
  PubMed ID: 15213134
   
  
• Chagas' disease susceptibility/resistance: linkage disequilibrium analysis suggests epistasis between major histocompatibility complex and interleukin-10.
  Moreno M, Silva EL, Ramírez LE, Palacio LG, Rivera D, Arcos-Burgos M
  Tissue Antigens. 2004
  PubMed ID: 15191519
   
  
• Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta.
  Elliott MR, Shanks RA, Khan IU, Brooks JW, Burkett PJ, Nelson BJ, Kyttaris V, Juang YT, Tsokos GC, Kammer GM
  J Immunol. 2004
  PubMed ID: 15187164
   
  
• A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery.
  Gherzi R, Lee KY, Briata P, Wegmüller D, Moroni C, Karin M, Chen CY
  Mol Cell. 2004
  PubMed ID: 15175153
   
  
• Looking for immunological risk genotypes.
  Caruso C, Aquino A, Candore G, Scola L, Colonna-Romano G, Lio D
  Ann N Y Acad Sci. 2004
  PubMed ID: 15247007
   
  
• Association of single nucleotide polymorphisms within cytokine genes with juvenile idiopathic arthritis in the Czech population.
  Cinek O, Vavrincová P, Striz I, Drevínek P, Sedláková P, Vavrinec J, Slavcev A
  J Rheumatol. 2004
  PubMed ID: 15170937
   
  
• Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
  Rowley TF, Al-Shamkhani A
  J Immunol. 2004
  PubMed ID: 15128787
   
  
• IL-2 induces a competitive survival advantage in T lymphocytes.
  Dooms H, Kahn E, Knoechel B, Abbas AK
  J Immunol. 2004
  PubMed ID: 15128779
   
  
• Ryanodine receptor signaling is required for anti-CD3-induced T cell proliferation, interleukin-2 synthesis, and interleukin-2 receptor signaling.
  Conrad DM, Hanniman EA, Watson CL, Mader JS, Hoskin DW
  J Cell Biochem. 2004
  PubMed ID: 15108363
   
  
• E2F1 promotes cytokine mediated cell survival via a mechanism that is separable from its cell cycle regulatory effects.
  Gala S, Williamson P
  Immunol Invest. 2004
  PubMed ID: 15195696
   
  
• Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.
  George S, Ruan XZ, Navarrete C, Turner D, Reynard M, Sweny P, Hamilton G, Wheeler DC, Powis SH, Moorhead JF, Varghese Z
  Tissue Antigens. 2004
  PubMed ID: 15104679
   
  
• Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10.
  Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA
  J Immunol. 2004
  PubMed ID: 15100259
   
  
• Myocyte enhancer factor 2 mediates calcium-dependent transcription of the interleukin-2 gene in T lymphocytes: a calcium signaling module that is distinct from but collaborates with the nuclear factor of activated T cells (NFAT).
  Pan F, Ye Z, Cheng L, Liu JO
  J Biol Chem. 2004
  PubMed ID: 14722108
   
  
• Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish.
  Ross OA, O'Neill C, Rea IM, Lynch T, Gosal D, Wallace A, Curran MD, Middleton D, Gibson JM
  Hum Immunol. 2004
  PubMed ID: 15120188
   
  
• HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination.
  Wang C, Tang J, Song W, Lobashevsky E, Wilson CM, Kaslow RA
  Hepatology. 2004
  PubMed ID: 15057902
   
  
• An abundance of Escherichia coli is harbored by the mucosa-associated bacterial flora of interleukin-2-deficient mice.
  Schuppler M, Lötzsch K, Waidmann M, Autenrieth IB
  Infect Immun. 2004
  PubMed ID: 15039318
   
  
• IL-2, regulatory T cells, and tolerance.
  Nelson BH
  J Immunol. 2004
  PubMed ID: 15034008
   
  
• IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells.
  Tuhácková Z, Sloncová E, Vojtechová M, Sovová V
  Int J Mol Med. 2004
  PubMed ID: 15010863
   
  
• Concentration of IL-2, IL-6, IL-8, IL-10 and TNF-alpha in children with acute lymphoblastic leukemia after cessation of chemotherapy.
  Mazur B, Mertas A, Sońta-Jakimczyk D, Szczepański T, Janik-Moszant A
  Hematol Oncol. 2004
  PubMed ID: 15152368
   
  
• Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg.
  Nieters A, Linseisen J, Becker N
  Clin Exp Allergy. 2004
  PubMed ID: 15005726
   
  
• Effects of the multiple sclerosis associated -330 promoter polymorphism in IL2 allelic expression.
  Matesanz F, Fedetz M, Leyva L, Delgado C, Fernández O, Alcina A
  J Neuroimmunol. 2004
  PubMed ID: 14975604
   
  
• IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells.
  Klebanoff CA, Finkelstein SE, Surman DR, Lichtman MK, Gattinoni L, Theoret MR, Grewal N, Spiess PJ, Antony PA, Palmer DC, Tagaya Y, Rosenberg SA, Waldmann TA, Restifo NP
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 14762166
   
  
• Disparate in vitro and in vivo requirements for IL-2 during antigen-independent CD8 T cell expansion.
  Wong P, Pamer EG
  J Immunol. 2004
  PubMed ID: 14764683
   
  
• Mechanisms of diarrhea in the interleukin-2-deficient mouse model of colonic inflammation.
  Barmeyer C, Harren M, Schmitz H, Heinzel-Pleines U, Mankertz J, Seidler U, Horak I, Wiedenmann B, Fromm M, Schulzke JD
  Am J Physiol Gastrointest Liver Physiol. 2004
  PubMed ID: 14715519
   
  
• Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.
  Oukka M, Wein MN, Glimcher LH
  J Exp Med. 2004
  PubMed ID: 14707112
   
  
• Influence of chronic interleukin-2 infusion and stressors on sickness behaviors and neurochemical change in mice.
  Sudom K, Turrin NP, Hayley S, Anisman H
  Neuroimmunomodulation. 2004
  PubMed ID: 15316245
   
  
• Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study.
  García-Tuñón I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M
  Breast Cancer Res. 2004
  PubMed ID: 14680494
   
  
• High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation.
  MacMillan ML, Radloff GA, Kiffmeyer WR, DeFor TE, Weisdorf DJ, Davies SM
  Transplantation. 2003
  PubMed ID: 14688528
   
  
• Combining Fas mutation with interleukin-2 deficiency prevents Colitis and Lupus: implicating interleukin-2 for auto-reactive T cell expansion and Fas ligand for colon epithelial cell death.
  Xiao S, Sung SS, Fu SM, Ju ST
  J Biol Chem. 2003
  PubMed ID: 14525977
   
  
• Effects of conjugated linoleic acid on growth and cytokine expression in Jurkat T cells.
  Luongo D, Bergamo P, Rossi M
  Immunol Lett. 2003
  PubMed ID: 14687725
   
  
• Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma.
  Howell WM, Turner SJ, Theaker JM, Bateman AC
  Eur J Immunogenet. 2003
  PubMed ID: 14675394
   
  
• Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin.
  Ashcroft AJ, Cruickshank SM, Croucher PI, Perry MJ, Rollinson S, Lippitt JM, Child JA, Dunstan C, Felsburg PJ, Morgan GJ, Carding SR
  Immunity. 2003
  PubMed ID: 14670302
   
  
• IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion.
  D'Souza WN, Lefrançois L
  J Immunol. 2003
  PubMed ID: 14634080
   
  
• Human CD94 gene expression: dual promoters differing in responsiveness to IL-2 or IL-15.
  Lieto LD, Borrego F, You CH, Coligan JE
  J Immunol. 2003
  PubMed ID: 14607929
   
  
• Specific signaling pathways triggered by IL-2 in human V gamma 9V delta 2 T cells: an amalgamation of NK and alpha beta T cell signaling.
  Lafont V, Loisel S, Liautard J, Dudal S, Sablé-Teychené M, Liautard JP, Favero J
  J Immunol. 2003
  PubMed ID: 14607923
   
  
• Cloning and characterization of ALX, an adaptor downstream of CD28.
  Greene TA, Powell P, Nzerem C, Shapiro MJ, Shapiro VS
  J Biol Chem. 2003
  PubMed ID: 12960172
   
  
• Plasmodium chabaudi adami: interferon-gamma but not IL-2 is essential for the expression of cell-mediated immunity against blood-stage parasites in mice.
  Batchelder JM, Burns JM, Cigel FK, Lieberg H, Manning DD, Pepper BJ, Yañez DM, van der Heyde H, Weidanz WP
  Exp Parasitol. 2003
  PubMed ID: 14969693
   
  
• Polymorphisms of IL-1B, IL-1RN, IL-2, IL-4, IL-6, IL-10, and IFN-gamma genes in the Korean population.
  Pyo CW, Hur SS, Kim YK, Choi HB, Hong YS, Kim DW, Kim CC, Kim HK, Kim TG
  Hum Immunol. 2003
  PubMed ID: 14522096
   
  
• Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.
  Mathews CE, Graser RT, Bagley RJ, Caldwell JW, Li R, Churchill GA, Serreze DV, Leiter EH
  Immunogenetics. 2003
  PubMed ID: 14513297
   
  
• CC chemokine ligand 2 and its receptor regulate mucosal production of IL-12 and TGF-beta in high dose oral tolerance.
  DePaolo RW, Rollins BJ, Kuziel W, Karpus WJ
  J Immunol. 2003
  PubMed ID: 14500652
   
  
• Essential role for STAT5 signaling in CD25+CD4+ regulatory T cell homeostasis and the maintenance of self-tolerance.
  Antov A, Yang L, Vig M, Baltimore D, Van Parijs L
  J Immunol. 2003
  PubMed ID: 14500638
   
  
• IL-2, IL-10, IL-15 and TNF are key regulators of murine T-cell lymphoma growth.
  Gravisaco MJ, Mongini C, Alvarez E, Ruybal P, Escalada A, Sanchez-Lockhart M, Hajos S, Waldner C
  Int J Mol Med. 2003
  PubMed ID: 12964046
   
  
• An IL-2-dependent switch between CD95 signaling pathways sensitizes primary human T cells toward CD95-mediated activation-induced cell death.
  Schmitz I, Krueger A, Baumann S, Schulze-Bergkamen H, Krammer PH, Kirchhoff S
  J Immunol. 2003
  PubMed ID: 12960316
   
  
• Cutting Edge: Multiple autoimmune pathways in kd/kd mice.
  Hancock WW, Tsai TL, Madaio MP, Gasser DL
  J Immunol. 2003
  PubMed ID: 12960297
   
  
• Involvement of CXCR4 and IL-2 in the homing and retention of human NK and NK T cells to the bone marrow and spleen of NOD/SCID mice.
  Beider K, Nagler A, Wald O, Franitza S, Dagan-Berger M, Wald H, Giladi H, Brocke S, Hanna J, Mandelboim O, Darash-Yahana M, Galun E, Peled A
  Blood. 2003
  PubMed ID: 12730102
   
  
• Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression.
  Vasilescu A, Heath SC, Ivanova R, Hendel H, Do H, Mazoyer A, Khadivpour E, Goutalier FX, Khalili K, Rappaport J, Lathrop GM, Matsuda F, Zagury JF
  Genes Immun. 2003
  PubMed ID: 12944981
   
  
• Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans.
  Biondo C, Beninati C, Bombaci M, Messina L, Mancuso G, Midiri A, Galbo R, Teti G
  Infect Immun. 2003
  PubMed ID: 12933895
   
  
• Habitual exercise did not affect the balance of type 1 and type 2 cytokines in elderly people.
  Ogawa K, Oka J, Yamakawa J, Higuchi M
  Mech Ageing Dev. 2003
  PubMed ID: 14499500
   
  
• Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones.
  Bayley JP, Bakker AM, Kaijzel EL, Wierenga EA, van der Pouw-Kraan TC, Huizinga TW, Verweij CL
  Eur J Immunol. 2003
  PubMed ID: 12884288
   
  
• Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways.
  Butler JJ, Mader JS, Watson CL, Zhang H, Blay J, Hoskin DW
  J Cell Biochem. 2003
  PubMed ID: 12874832
   
  
• Relative abundance and patterns of correlation among six cytokines in pleural fluid measured by cytometric bead array.
  Aoe K, Hiraki A, Murakami T, Murakami K, Makihata K, Takao K, Eda R, Maeda T, Sugi K, Darzynkiewicz Z, Takeyama H
  Int J Mol Med. 2003
  PubMed ID: 12851716
   
  
• Loss of Hmga1 gene function affects embryonic stem cell lympho-hematopoietic differentiation.
  Battista S, Pentimalli F, Baldassarre G, Fedele M, Fidanza V, Croce CM, Fusco A
  FASEB J. 2003
  PubMed ID: 12824305
   
  
• Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development.
  Yagi J, Arimura Y, Dianzani U, Uede T, Okamoto T, Uchiyama T
  J Immunol. 2003
  PubMed ID: 12847246
   
  
• Effect of interleukin 1alpha and interleukin 2 over glucose metabolism in isolated uterus of restricted diet rats. Influence of NO and COX-2.
  Linares JA, Campos ML, Goldraij A
  Prostaglandins Leukot Essent Fatty Acids. 2003
  PubMed ID: 12878449
   
  
• Contrasting effects of interleukin-2 secretion by rat glioma cells contingent upon anatomical location: accelerated tumorigenesis in the central nervous system and complete rejection in the periphery.
  Graf MR, Prins RM, Poulsen GA, Merchant RE
  J Neuroimmunol. 2003
  PubMed ID: 12864971
   
  
• Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice.
  Waidmann M, Bechtold O, Frick JS, Lehr HA, Schubert S, Dobrindt U, Loeffler J, Bohn E, Autenrieth IB
  Gastroenterology. 2003
  PubMed ID: 12851881
   
  
• Homeostasis of naive and memory CD4+ T cells: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis.
  Jaleco S, Swainson L, Dardalhon V, Burjanadze M, Kinet S, Taylor N
  J Immunol. 2003
  PubMed ID: 12816983
   
  
• Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor.
  Devireddy LR, Green MR
  Mol Cell Biol. 2003
  PubMed ID: 12808095
   
  
• IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells.
  Bream JH, Curiel RE, Yu CR, Egwuagu CE, Grusby MJ, Aune TM, Young HA
  Blood. 2003
  PubMed ID: 12637316
   
  
• Upregulation of IL-2 but not IL-15 by allorecognition in human mixed lymphocyte culture.
  Praditpornsilpa K, Wang W, Chan L
  Transplant Proc. 2003
  PubMed ID: 12826231
   
  
• Interleukin-2 gene polymorphism is associated with renal but not cardiac transplant outcome.
  Morgun A, Shulzhenko N, Rampim GF, Medina JO, Machado PG, Diniz RV, Almeida DR, Gerbase-DeLima M
  Transplant Proc. 2003
  PubMed ID: 12826155
   
  
• Propagation and control of T cell responses by heparan sulfate-bound IL-2.
  Wrenshall LE, Platt JL, Stevens ET, Wight TN, Miller JD
  J Immunol. 2003
  PubMed ID: 12759423
   
  
• Identification of a protein fragment of interleukin 2 responsible for vasopermeability.
  Epstein AL, Mizokami MM, Li J, Hu P, Khawli LA
  J Natl Cancer Inst. 2003
  PubMed ID: 12759392
   
  
• Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming.
  Granucci F, Feau S, Angeli V, Trottein F, Ricciardi-Castagnoli P
  J Immunol. 2003
  PubMed ID: 12734352
   
  
• Stochastic model of T cell proliferation: a calculus revealing IL-2 regulation of precursor frequencies, cell cycle time, and survival.
  Deenick EK, Gett AV, Hodgkin PD
  J Immunol. 2003
  PubMed ID: 12734339
   
  
• pH Dependence of structural stability of interleukin-2 and granulocyte colony-stimulating factor.
  Ricci MS, Sarkar CA, Fallon EM, Lauffenburger DA, Brems DN
  Protein Sci. 2003
  PubMed ID: 12717025
   
  
• Ref-1 protein enhances the IL-2-stimulated telomerase activity.
  Xu W, Yan M, Sun L, Zheng Z, Liu X
  J Cell Biochem. 2003
  PubMed ID: 12647295
   
  
• CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.
  Fehniger TA, Cooper MA, Nuovo GJ, Cella M, Facchetti F, Colonna M, Caligiuri MA
  Blood. 2003
  PubMed ID: 12480696
   
  
• Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.
  Fukuda K, Yoshida H, Sato T, Furumoto TA, Mizutani-Koseki Y, Suzuki Y, Saito Y, Takemori T, Kimura M, Sato H, Taniguchi M, Nishikawa S, Nakayama T, Koseki H
  Dev Biol. 2003
  PubMed ID: 12648490
   
  
• The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis.
  Krummrei U, Baulieu EE, Chambraud B
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12604780
   
  
• Induction of innate immunity by IL-2-expressing Salmonella confers protection against lethal infection.
  al-Ramadi BK, Mustafa N, AbouHaidar M, Fernandez-Cabezudo MJ
  Mol Immunol. 2003
  PubMed ID: 12617991
   
  
• Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis.
  Fedetz M, Matesanz F, Cáliz R, Ferrer MA, Collado MD, Alcina A, Martín J
  J Rheumatol. 2003
  PubMed ID: 12610796
   
  
• Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes.
  Kryworuchko M, Pasquier V, Thèze J
  Clin Exp Immunol. 2003
  PubMed ID: 12605694
   
  
• A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production by Jurkat cells.
  Sakakibara A, Hattori S, Nakamura S, Katagiri T
  J Biol Chem. 2003
  PubMed ID: 12486027
   
  
• Binding of small molecules to an adaptive protein-protein interface.
  Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12582206
   
  
• Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.
  Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG
  J Biol Chem. 2003
  PubMed ID: 12464620
   
  
• Study of age-association with cytokine gene polymorphisms in an aged Irish population.
  Ross OA, Curran MD, Meenagh A, Williams F, Barnett YA, Middleton D, Rea IM
  Mech Ageing Dev. 2003
  PubMed ID: 12633940
   
  
• A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS).
  Harada Y, Ohgai D, Watanabe R, Okano K, Koiwai O, Tanabe K, Toma H, Altman A, Abe R
  J Exp Med. 2003
  PubMed ID: 12538664
   
  
• Population frequencies of single nucleotide polymorphisms (SNPs) in immuno-modulatory genes.
  Martin AM, Athanasiadis G, Greshock JD, Fisher J, Lux MP, Calzone K, Rebbeck TR, Weber BL
  Hum Hered. 2003
  PubMed ID: 14566095
   
  
• Recipient gene polymorphisms in the Th-1 cytokines IL-2 and IFN-gamma in relation to acute rejection and graft vascular disease after clinical heart transplantation.
  Holweg CT, Peeters AM, Balk AH, Uitterlinden AG, Niesters HG, Maat AP, Weimar W, Baan CC
  Transpl Immunol. 2003
  PubMed ID: 12727483
   
  
• Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients.
  McDaniel DO, Barber WH, Nguyan C, Rhodes SW, May WL, McDaniel LS, Vig PJ, Jemeson LL, Butkus DE
  Transpl Immunol. 2003
  PubMed ID: 12727482
   
  
• Interleukin-2 production by peripheral blood mononuclear cells from patients with myasthenia gravis.
  Utsugisawa K, Nagane Y, Obara D, Kondoh R, Yonezawa H, Tohgi H
  Eur Neurol. 2003
  PubMed ID: 12646760
   
  
• HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines.
  Vitale M, Caruso A, De Francesco MA, Rodella L, Bozzo L, Garrafa E, Grassi M, Gobbi G, Cacchioli A, Fiorentini S
  Br J Haematol. 2003
  PubMed ID: 12542496
   
  
• Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line.
  García-Lora A, Martinez M, Pedrinaci S, Garrido F
  Cancer Immunol Immunother. 2003
  PubMed ID: 12536241
   
  
• IL-2 gene knockout affects T lymphocyte trafficking and the microglial response to regenerating facial motor neurons.
  Petitto JM, Huang Z, Lo J, Streit WJ
  J Neuroimmunol. 2003
  PubMed ID: 12507776
   
  
• Autoreactive T cells promote post-traumatic healing in the central nervous system.
  Hofstetter HH, Sewell DL, Liu F, Sandor M, Forsthuber T, Lehmann PV, Fabry Z
  J Neuroimmunol. 2003
  PubMed ID: 12507769
   
  
• Regulation of Akt-dependent cell survival by Syk and Rac.
  Jiang K, Zhong B, Ritchey C, Gilvary DL, Hong-Geller E, Wei S, Djeu JY
  Blood. 2003
  PubMed ID: 12393431
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• An assessment of the association between IL-2 gene polymorphisms and Japanese patients with multiple sclerosis.
  Kikuchi S, Niino M, Fukazawa T, Yabe I, Tashiro K
  J Neurol Sci. 2002
  PubMed ID: 12409183
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
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• Association of IL2, TNFA, IL4 and IL10 Promoter Gene Polymorphisms with the Rate of Progression of the HIV Infection.
  Smolnikova MV, Konenkov VI
  Russ J Immunol. 2002
  PubMed ID: 12687247
   
  
• Hematopoietic stem cell functional failure in interleukin-2-deficient mice.
  Chen J, Astle CM, Harrison DE
  J Hematother Stem Cell Res. 2002
  PubMed ID: 12590705
   
  
• [Role of cytokines for maintenance of memory CD8+ T cells]
  Kamon H, Murakami M
  Tanpakushitsu Kakusan Koso. 2002
  PubMed ID: 12518454
   
  
• Nuclear export of NF90 is required for interleukin-2 mRNA stabilization.
  Shim J, Lim H, R Yates J, Karin M
  Mol Cell. 2002
  PubMed ID: 12504009
   
  
• Effective anti-tumor adoptive immunotherapy: utilization of exogenous IL-2-independent cytotoxic T lymphocyte clones.
  Iwashiro M, Jinyan W, Toda M, Linan W, Kato T, Kuribayashi K
  Int Immunol. 2002
  PubMed ID: 12456594
   
  
• Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout.
  Beck RD, King MA, Huang Z, Petitto JM
  Brain Res. 2002
  PubMed ID: 12419517
   
  
• Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America.
  Meenagh A, Williams F, Ross OA, Patterson C, Gorodezky C, Hammond M, Leheny WA, Middleton D
  Hum Immunol. 2002
  PubMed ID: 12392859
   
  
• Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.
  Almeida AR, Legrand N, Papiernik M, Freitas AA
  J Immunol. 2002
  PubMed ID: 12391195
   
  
• Enhanced clearance of herpes simplex virus type 1 and reduced herpetic eye disease in STAT6 knockout mice is associated with increased IL-2.
  Ghiasi H, Osorio Y, Nesburn AB, Wechsler SL
  Virology. 2002
  PubMed ID: 12441072
   
  
• A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation.
  Massberg S, Brand K, Grüner S, Page S, Müller E, Müller I, Bergmeier W, Richter T, Lorenz M, Konrad I, Nieswandt B, Gawaz M
  J Exp Med. 2002
  PubMed ID: 12370251
   
  
• Interleukin-7 (IL-7) in patients receiving intensive chemotherapy for acute myelogenous leukemia: studies of systemic IL-7 Levels and IL-7 responsiveness of circulating T lymphocytes.
  Wendelbo Ø, Glenjen N, Bruserud Ø
  J Interferon Cytokine Res. 2002
  PubMed ID: 12433286
   
  
• Analysis of -631 and -475 interleukin-2 promoter single nucleotide polymorphisms in multiple sclerosis.
  Fedetz M, Alcina A, Fernández O, Guerrero M, Delgado C, Matesanz F
  Eur J Immunogenet. 2002
  PubMed ID: 12358847
   
  
• Lymphoadenopathy in IL-2-deficient mice: further characterization and overexpression of the antiapoptotic molecule cellular FLIP.
  Chastagner P, Reddy J, Thèze J
  J Immunol. 2002
  PubMed ID: 12244156
   
  
• IL-12 provides proliferation and survival signals to murine CD4+ T cells through phosphatidylinositol 3-kinase/Akt signaling pathway.
  Yoo JK, Cho JH, Lee SW, Sung YC
  J Immunol. 2002
  PubMed ID: 12244155
   
  
• Long-term effects of intermittent interleukin 2 therapy in patients with HIV infection: characterization of a novel subset of CD4(+)/CD25(+) T cells.
  Sereti I, Martinez-Wilson H, Metcalf JA, Baseler MW, Hallahan CW, Hahn B, Hengel RL, Davey RT, Kovacs JA, Lane HC
  Blood. 2002
  PubMed ID: 12200381
   
  
• CD4 T lymphocytes cause hepatocyte apoptosis by releasing Th1 cytokines in cellular immunological liver injury.
  Xu Q, Chen XC
  Inflamm Res. 2002
  PubMed ID: 12365717
   
  
• The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production.
  Pradhan D, Morrow J
  Immunity. 2002
  PubMed ID: 12354383
   
  
• The human IL-2 gene promoter can assemble a positioned nucleosome that becomes remodeled upon T cell activation.
  Attema JL, Reeves R, Murray V, Levichkin I, Temple MD, Tremethick DJ, Shannon MF
  J Immunol. 2002
  PubMed ID: 12193716
   
  
• Overexpression of interleukin-2 by a recombinant herpes simplex virus type 1 attenuates pathogenicity and enhances antiviral immunity.
  Ghiasi H, Osorio Y, Perng GC, Nesburn AB, Wechsler SL
  J Virol. 2002
  PubMed ID: 12186890
   
  
• Susceptibility of interleukin-2-deficient mice to Toxoplasma gondii is associated with a defect in the production of gamma interferon.
  Villegas EN, Lieberman LA, Carding SR, Hunter CA
  Infect Immun. 2002
  PubMed ID: 12183516
   
  
• DOCK2 mediates T cell receptor-induced activation of Rac2 and IL-2 transcription.
  Nishihara H, Maeda M, Tsuda M, Makino Y, Sawa H, Nagashima K, Tanaka S
  Biochem Biophys Res Commun. 2002
  PubMed ID: 12176041
   
  
• IL-2 and autoimmune disease.
  Schimpl A, Berberich I, Kneitz B, Krämer S, Santner-Nanan B, Wagner S, Wolf M, Hünig T
  Cytokine Growth Factor Rev. 2002
  PubMed ID: 12220550
   
  
• CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.
  Malek TR, Yu A, Vincek V, Scibelli P, Kong L
  Immunity. 2002
  PubMed ID: 12196288
   
  
• Frequencies of the -330 (T --> G) IL-2 and -590 (T --> C) IL-4 gene polymorphisms in a population from south-eastern Brazil.
  Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Line SR
  Eur J Immunogenet. 2002
  PubMed ID: 12121273
   
  
• HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor.
  De Francesco MA, Baronio M, Fiorentini S, Signorini C, Bonfanti C, Poiesi C, Popovic M, Grassi M, Garrafa E, Bozzo L, Lewis GK, Licenziati S, Gallo RC, Caruso A
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12105273
   
  
• Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis.
  Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Line SR
  J Clin Periodontol. 2002
  PubMed ID: 12354082
   
  
• Induction of interleukin-2 receptor alpha (IL-2Ralpha) expression by interleukin-2: important role of the interleukin-2 receptor beta chain region between the two Stat5 docking sites.
  Imbert V, Rezzonico R, Reichenbach P, Nabholz M
  Eur Cytokine Netw. 2002
  PubMed ID: 12231477
   
  
• Cytokine gene polymorphisms and acute human liver graft rejection.
  Warlé MC, Farhan A, Metselaar HJ, Hop WC, Perrey C, Zondervan PE, Kap M, de Rave S, Kwekkeboom J, Ijzermans JN, Tilanus HW, Pravica V, Hutchinson IV, Bouma GJ
  Liver Transpl. 2002
  PubMed ID: 12089714
   
  
• Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants.
  Pedroza-Martins L, Boscardin WJ, Anisman-Posner DJ, Schols D, Bryson YJ, Uittenbogaart CH
  J Virol. 2002
  PubMed ID: 12072494
   
  
• Early antigen-specific response by naive CD8 T cells is not altered with aging.
  Li SP, Cai Z, Shi W, Brunmark A, Jackson M, Linton PJ
  J Immunol. 2002
  PubMed ID: 12055223
   
  
• IL-2 and IL-12 alter NK cell responsiveness to IFN-gamma-inducible protein 10 by down-regulating CXCR3 expression.
  Hodge DL, Schill WB, Wang JM, Blanca I, Reynolds DA, Ortaldo JR, Young HA
  J Immunol. 2002
  PubMed ID: 12055219
   
  
• Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system.
  Bemiss CJ, Mahon BD, Henry A, Weaver V, Cantorna MT
  Arch Biochem Biophys. 2002
  PubMed ID: 12051670
   
  
• Reduced cytokine secretions by LAK cells of pulmonary tuberculosis patients in response to tumor targets in vitro.
  Nirmala R, Mathew R, Narayanan PR
  J Interferon Cytokine Res. 2002
  PubMed ID: 12162871
   
  
• The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2.
  Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM, Medema RH
  J Immunol. 2002
  PubMed ID: 11994454
   
  
• Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL).
  Rossmann ED, Lewin N, Jeddi-Tehrani M, Osterborg A, Mellstedt H
  Eur J Haematol. 2002
  PubMed ID: 12144536
   
  
• [Enhancement of antigen presenting function of dendritic cells by IL-2 gene modification and its mechanism]
  Sun L, Liu J, Cao X, Zhang M, Zhou Y, Liu B, Shi H
  Zhonghua Xue Ye Xue Za Zhi. 2002
  PubMed ID: 12133446
   
  
• The leptin defense against wasting is abolished in the IL-2-deficient mouse model of inflammatory bowel disease.
  Gaetke LM, Oz HS, de Villiers WJ, Varilek GW, Frederich RC
  J Nutr. 2002
  PubMed ID: 11983809
   
  
• Effect of HLA-DR matching on acute rejection after clinical heart transplantation might be influenced by an IL-2 gene polymorphism.
  Holweg CT, Peeters AM, Balk AH, Uitterlinden AG, Niesters HG, Maat AP, Weimar W, Baan CC
  Transplantation. 2002
  PubMed ID: 11981437
   
  
• Genetic analysis of autoimmune sialadenitis in nonobese diabetic mice: a major susceptibility region on chromosome 1.
  Boulard O, Fluteau G, Eloy L, Damotte D, Bedossa P, Garchon HJ
  J Immunol. 2002
  PubMed ID: 11937580
   
  
• Interleukin-2 in the pathogenesis of perinatal white matter damage.
  Kadhim H, Tabarki B, De Prez C, Rona AM, Sébire G
  Neurology. 2002
  PubMed ID: 11940709
   
  
• Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain.
  Olosz F, Malek TR
  J Biol Chem. 2002
  PubMed ID: 11815609
   
  
• Vomitoxin (deoxynivalenol)-mediated inhibition of nuclear protein binding to NRE-A, an IL-2 promoter negative regulatory element, in EL-4 cells.
  Yang GH, Pestka JJ
  Toxicology. 2002
  PubMed ID: 11893416
   
  
• Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4.
  Mita Y, Dobashi K, Endou K, Kawata T, Shimizu Y, Nakazawa T, Mori M
  Immunol Lett. 2002
  PubMed ID: 11841848
   
  
• Insertion of interleukin-2 (IL-2) and interleukin-12 (IL-12) genes into vaccinia virus results in effective anti-tumor responses without toxicity.
  Kaufman HL, Flanagan K, Lee CS, Perretta DJ, Horig H
  Vaccine. 2002
  PubMed ID: 11906776
   
  
• The influence of gammadelta T cells on the CD4+ T cell and antibody response during a primary Plasmodium chabaudi chabaudi infection in mice.
  Seixas E, Fonseca L, Langhorne J
  Parasite Immunol. 2002
  PubMed ID: 11982858
   
  
• Hypo-active variant of IL-2 and associated decreased T cell activation contribute to impaired apoptosis in autoimmune prone MRL mice.
  Choi Y, Simon-Stoos K, Puck JM
  Eur J Immunol. 2002
  PubMed ID: 11857342
   
  
• PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2.
  Carter L, Fouser LA, Jussif J, Fitz L, Deng B, Wood CR, Collins M, Honjo T, Freeman GJ, Carreno BM
  Eur J Immunol. 2002
  PubMed ID: 11857337
   
  
• Molecular mechanism of NFAT family proteins for differential regulation of the IL-2 and TNF-alpha promoters.
  Oum JH, Han J, Myung H, Hleb M, Sharma S, Park J
  Mol Cells. 2002
  PubMed ID: 11911478
   
  
• Similarity between eruptions induced by sulfhydryl drugs and acute cutaneous graft-versus-host disease after bone marrow transplantation.
  Takatsuka H, Takemoto Y, Yamada S, Mori A, Wada H, Fujimori Y, Okamoto T, Kanamaru A, Kakishita E
  Hematology. 2002
  PubMed ID: 12171778
   
  
• Opioid receptor-mediated effects of interleukin-2 on the [Ca2+]i transient and contraction in isolated ventricular myocytes of the rat.
  Cao CM, Xia Q, Chen YY, Zhang X, Shen YL
  Pflugers Arch. 2002
  PubMed ID: 11907831
   
  
• The role of the IL-2 pathway in costimulation blockade-resistant rejection of allografts.
  Jones TR, Ha J, Williams MA, Adams AB, Durham MM, Rees PA, Cowan SR, Pearson TC, Larsen CP
  J Immunol. 2002
  PubMed ID: 11801646
   
  
• IL-2 and related cytokines can promote T cell survival by activating AKT.
  Kelly E, Won A, Refaeli Y, Van Parijs L
  J Immunol. 2002
  PubMed ID: 11777951
   
  
• The interleukin-2-deficient mouse model.
  Barmeyer C, Horak I, Zeitz M, Fromm M, Schulzke JD
  Pathobiology. 2002
  PubMed ID: 12571417
   
  
• Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitis.
  Malley SE, Vizzard MA
  Physiol Genomics. 2002
  PubMed ID: 11948286
   
  
• Recombinant interleukin-2 treatment decreases P-glycoprotein activity and paclitaxel metabolism in mice.
  Bonhomme-Faivre L, Pelloquin A, Tardivel S, Urien S, Mathieu MC, Castagne V, Lacour B, Farinotti R
  Anticancer Drugs. 2002
  PubMed ID: 11914641
   
  
• Kinetic and mechanistic analysis of the RNA polymerase II transcrption reaction at the human interleukin-2 promoter.
  Ferguson HA, Kugel JF, Goodrich JA
  J Mol Biol. 2001
  PubMed ID: 11743717
   
  
• TCR engagement in the absence of cell cycle progression leads to T cell anergy independent of p27(Kip1).
  Powell JD, Bruniquel D, Schwartz RH
  Eur J Immunol. 2001
  PubMed ID: 11745394
   
  
• A central role for IL-2 in fate determination of mature T cells--I: role in determining the Th1/Th2 profile in primary T cell cultures.
  Raju K, Rabinovich BA, Radvanyi LG, Spaner D, Miller RG
  Int Immunol. 2001
  PubMed ID: 11717186
   
  
• Transduction of an IL-2 gene into human melanoma-reactive lymphocytes results in their continued growth in the absence of exogenous IL-2 and maintenance of specific antitumor activity.
  Liu K, Rosenberg SA
  J Immunol. 2001
  PubMed ID: 11714800
   
  
• Induction of TAK (cyclin T1/P-TEFb) in purified resting CD4(+) T lymphocytes by combination of cytokines.
  Ghose R, Liou LY, Herrmann CH, Rice AP
  J Virol. 2001
  PubMed ID: 11689614
   
  
• Age- and stage-specific regulation patterns in the hematopoietic stem cell hierarchy.
  Geiger H, True JM, de Haan G, Van Zant G
  Blood. 2001
  PubMed ID: 11698278
   
  
• ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse.
  Allenspach EJ, Cullinan P, Tong J, Tang Q, Tesciuba AG, Cannon JL, Takahashi SM, Morgan R, Burkhardt JK, Sperling AI
  Immunity. 2001
  PubMed ID: 11728336
   
  
• Disrupted B-lymphocyte development and survival in interleukin-2-deficient mice.
  Schultz M, Clarke SH, Arnold LW, Sartor RB, Tonkonogy SL
  Immunology. 2001
  PubMed ID: 11683951
   
  
• Molecular genetics of ulcerative colitis-associated colon cancer in the interleukin 2- and beta(2)-microglobulin-deficient mouse.
  Sohn KJ, Shah SA, Reid S, Choi M, Carrier J, Comiskey M, Terhorst C, Kim YI
  Cancer Res. 2001
  PubMed ID: 11559569
   
  
• Allelic expression and interleukin-2 polymorphisms in multiple sclerosis.
  Matesanz F, Fedetz M, Collado-Romero M, Fernández O, Guerrero M, Delgado C, Alcina A
  J Neuroimmunol. 2001
  PubMed ID: 11525806
   
  
• Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6.
  Cox ED, Hoffmann SC, DiMercurio BS, Wesley RA, Harlan DM, Kirk AD, Blair PJ
  Transplantation. 2001
  PubMed ID: 11544437
   
  
• Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells.
  Breloer M, Dorner B, Moré SH, Roderian T, Fleischer B, von Bonin A
  Eur J Immunol. 2001
  PubMed ID: 11449358
   
  
• Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.
  Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K
  J Immunol. 2001
  PubMed ID: 11418623
   
  
• The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat.
  Ehret A, Li-Weber M, Frank R, Krammer PH
  Eur J Immunol. 2001
  PubMed ID: 11385624
   
  
• Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms.
  Wolf M, Schimpl A, Hünig T
  Eur J Immunol. 2001
  PubMed ID: 11385607
   
  
• Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.
  Biggs WH, Cavenee WK, Arden KC
  Mamm Genome. 2001
  PubMed ID: 11353388
   
  
• A requirement for IL-2/IL-2 receptor signaling in intrathymic negative selection.
  Bassiri H, Carding SR
  J Immunol. 2001
  PubMed ID: 11342609
   
  
• The influence of genetic background on spontaneous and genetically engineered mouse models of complex diseases.
  Linder CC
  Lab Anim (NY). 2001
  PubMed ID: 11385732
   
  
• A defined conformational epitope from the C4 domain of HIV type 1 glycoprotein 120: anti-cyclic C4 antibodies from HIV-positive donors magnify glycoprotein 120 suppression of interleukin 2 produced by T cells.
  Robey FA, Robert-Guroff M
  AIDS Res Hum Retroviruses. 2001
  PubMed ID: 11350667
   
  
• Serum levels of endothelin-1 (ET-1), interleukin-2 (IL-2) and amino-terminal propeptide type III procollagen (PIII NP) in patients with acute and chronic filariasis.
  el-Sharkawy IM, Haseeb AN, Saleh WA
  J Egypt Soc Parasitol. 2001
  PubMed ID: 12557940
   
  
• Cytokine gene polymorphisms and susceptibility to juvenile idiopathic arthritis. British Paediatric Rheumatology Study Group.
  Donn RP, Barrett JH, Farhan A, Stopford A, Pepper L, Shelley E, Davies N, Ollier WE, Thomson W
  Arthritis Rheum. 2001
  PubMed ID: 11315919
   
  
• HIV-1 Tat inhibits IL-2 gene transcription through qualitative and quantitative alterations of the cooperative Rel/AP1 complex bound to the CD28RE/AP1 composite element of the IL-2 promoter.
  González E, Punzón C, González M, Fresno M
  J Immunol. 2001
  PubMed ID: 11254713
   
  
• Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population.
  Nieters A, Brems S, Becker N
  Hum Genet. 2001
  PubMed ID: 11354638
   
  
• A p74 common gamma receptor chain isoform facilitates IL-2 and IL-15 responses by the myelomonocytic cell line Tf-1beta2.
  Monson NL, Fenske TJ, Wei S, Okragly AJ, de Jong JL, Haak-Frendscho M, O'Shea J, Djeu J, Sondel PM
  J Leukoc Biol. 2001
  PubMed ID: 11261789
   
  
• IL-2-induced tumor necrosis factor (TNF)-beta expression: further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation.
  Reddy J, Chastagner P, Fiette L, Liu X, Thèze J
  Int Immunol. 2001
  PubMed ID: 11157847
   
  
• Complete regression of established spontaneous mammary carcinoma and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: induction of local T cell infiltration, Fas/Fas ligand gene expression, and mammary epithe
  Wigginton JM, Park JW, Gruys ME, Young HA, Jorcyk CL, Back TC, Brunda MJ, Strieter RM, Ward J, Green JE, Wiltrout RH
  J Immunol. 2001
  PubMed ID: 11145697
   
  
• IL-15 and IL-2: a matter of life and death for T cells in vivo.
  Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, Strom TB
  Nat Med. 2001
  PubMed ID: 11135625
   
  
• Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication.
  Secchiero P, Zella D, Curreli S, Mirandola P, Capitani S, Gallo RC, Zauli G
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 11114167
   
  
• Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice.
  Mitsos LM, Cardon LR, Fortin A, Ryan L, LaCourse R, North RJ, Gros P
  Genes Immun. 2000
  PubMed ID: 11197687
   
  
• Allelic selection of human IL-2 gene.
  Matesanz F, Delgado C, Fresno M, Alcina A
  Eur J Immunol. 2000
  PubMed ID: 11093171
   
  
• Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts.
  Zand MS, Li Y, Hancock W, Li XC, Roy-Chaudhury P, Zheng XX, Strom TB
  Transplantation. 2000
  PubMed ID: 11087156
   
  
• IL-2R beta agonist P1-30 acts in synergy with IL-2, IL-4, IL-9, and IL-15: biological and molecular effects.
  Eckenberg R, Moreau JL, Melnyk O, Thèze J
  J Immunol. 2000
  PubMed ID: 11035066
   
  
• The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells.
  Dai Z, Konieczny BT, Lakkis FG
  J Immunol. 2000
  PubMed ID: 10975812
   
  
• Increased serum amyloid a levels reflect colitis severity and precede amyloid formation in IL-2 knockout mice.
  de Villiers WJ, Varilek GW, de Beer FC, Guo JT, Kindy MS
  Cytokine. 2000
  PubMed ID: 10975993
   
  
• Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii.
  Cai G, Radzanowski T, Villegas EN, Kastelein R, Hunter CA
  J Immunol. 2000
  PubMed ID: 10946290
   
  
• HIV-Nef enhances interleukin-2 production and phosphatidylinositol 3-kinase activity in a human T cell line.
  Schibeci SD, Clegg AO, Biti RA, Sagawa K, Stewart GJ, Williamson P
  AIDS. 2000
  PubMed ID: 10985305
   
  
• Restriction landmark genomic scanning of mouse liver tumors for gene amplification: overexpression of cyclin A2.
  Haddad R, Morrow AD, Plass C, Held WA
  Biochem Biophys Res Commun. 2000
  PubMed ID: 10903917
   
  
• Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators.
  Ariel A, Lider O, Brill A, Cahalon L, Savion N, Varon D, Hershkoviz R
  Immunology. 2000
  PubMed ID: 10929056
   
  
• The role of IL-2 in allograft rejection--a lesson learned from experimental work.
  Stepkowski SM, Kirken RA
  Transplantation. 2000
  PubMed ID: 10910265
   
  
• Neuroendocrine changes in colon of mice with a disrupted IL-2 gene.
  Qian BF, El-Salhy M, Melgar S, Hammarström ML, Danielsson A
  Clin Exp Immunol. 2000
  PubMed ID: 10844519
   
  
• Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.
  Zhou YJ, Magnuson KS, Cheng TP, Gadina M, Frucht DM, Galon J, Candotti F, Geahlen RL, Changelian PS, O'Shea JJ
  Mol Cell Biol. 2000
  PubMed ID: 10825200
   
  
• The role of Stat5a and Stat5b in signaling by IL-2 family cytokines.
  Lin JX, Leonard WJ
  Oncogene. 2000
  PubMed ID: 10851055
   
  
• Interleukin-2 gene deletion produces a robust reduction in susceptibility to experimental autoimmune encephalomyelitis in C57BL/6 mice.
  Petitto JM, Streit WJ, Huang Z, Butfiloski E, Schiffenbauer J
  Neurosci Lett. 2000
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• Intestinal inflammation observed in IL-2R/IL-2 mutant mice is associated with impaired intestinal T lymphopoiesis.
  Poussier P, Ning T, Chen J, Banerjee D, Julius M
  Gastroenterology. 2000
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• Dissection of behavior and psychiatric disorders using the mouse as a model.
  Tarantino LM, Bucan M
  Hum Mol Genet. 2000
  PubMed ID: 10767319
   
  
• The emerging role of IL-15 in NK-cell development.
  Liu CC, Perussia B, Young JD
  Immunol Today. 2000
  PubMed ID: 10689297
   
  
• The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells.
  Eckenberg R, Rose T, Moreau JL, Weil R, Gesbert F, Dubois S, Tello D, Bossus M, Gras H, Tartar A, Bertoglio J, Chouaïb S, Goldberg M, Jacques Y, Alzari PM, Thèze J
  J Exp Med. 2000
  PubMed ID: 10662798
   
  
• The Nef protein of HIV-1 associates with rafts and primes T cells for activation.
  Wang JK, Kiyokawa E, Verdin E, Trono D
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10618429
   
  
• Role of costimulation in the induction of the IL-12/IL-12 receptor pathway and the development of autoimmunity.
  Chang JT, Segal BM, Shevach EM
  J Immunol. 2000
  PubMed ID: 10604999
   
  
• The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.
  Sotsios Y, Whittaker GC, Westwick J, Ward SG
  J Immunol. 1999
  PubMed ID: 10570282
   
  
• IL-2Rbeta/IL-7Ralpha doubly deficient mice recapitulate the thymic and intraepithelial lymphocyte (IEL) developmental defects of gammac-/- mice: roles for both IL-2 and IL-15 in CD8alphaalpha IEL development.
  Porter BO, Malek TR
  J Immunol. 1999
  PubMed ID: 10570276
   
  
• Increased nuclear factor-kappaB activation in colitis of interleukin-2-deficient mice.
  Yang F, de Villiers WJ, Lee EY, McClain CJ, Varilek GW
  J Lab Clin Med. 1999
  PubMed ID: 10521084
   
  
• Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells.
  Moriggl R, Sexl V, Piekorz R, Topham D, Ihle JN
  Immunity. 1999
  PubMed ID: 10485657
   
  
• CD28, IL-2-independent costimulatory pathways for CD8 T lymphocyte activation.
  Sepulveda H, Cerwenka A, Morgan T, Dutton RW
  J Immunol. 1999
  PubMed ID: 10415007
   
  
• HIV-1 Nef increases T cell activation in a stimulus-dependent manner.
  Schrager JA, Marsh JW
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 10393966
   
  
• IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation.
  Schultz M, Tonkonogy SL, Sellon RK, Veltkamp C, Godfrey VL, Kwon J, Grenther WB, Balish E, Horak I, Sartor RB
  Am J Physiol. 1999
  PubMed ID: 10362650
   
  
• Impaired learning and memory and altered hippocampal neurodevelopment resulting from interleukin-2 gene deletion.
  Petitto JM, McNamara RK, Gendreau PL, Huang Z, Jackson AJ
  J Neurosci Res. 1999
  PubMed ID: 10340751
   
  
• Reciprocal modulatory interaction between human immunodeficiency virus type 1 Tat and transcription factor NFAT1.
  Macián F, Rao A
  Mol Cell Biol. 1999
  PubMed ID: 10207088
   
  
• Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.
  Glushakova S, Grivel JC, Suryanarayana K, Meylan P, Lifson JD, Desrosiers R, Margolis L
  J Virol. 1999
  PubMed ID: 10196292
   
  
• Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice.
  Lúdvíksson BR, Strober W, Nishikomori R, Hasan SK, Ehrhardt RO
  J Immunol. 1999
  PubMed ID: 10202045
   
  
• Cutting edge: sustained expansion of CD8+ T cells requires CD154 expression by Th cells in acute graft versus host disease.
  Buhlmann JE, Gonzalez M, Ginther B, Panoskaltsis-Mortari A, Blazar BR, Greiner DL, Rossini AA, Flavell R, Noelle RJ
  J Immunol. 1999
  PubMed ID: 10201970
   
  
• Protective role of beta-chemokines associated with HIV-specific Th responses against perinatal HIV transmission.
  Wasik TJ, Bratosiewicz J, Wierzbicki A, Whiteman VE, Rutstein RR, Starr SE, Douglas SD, Kaufman D, Sison AV, Polansky M, Lischner HW, Kozbor D
  J Immunol. 1999
  PubMed ID: 10201969
   
  
• IL-2-dependent expression of genes involved in cytoskeleton organization, oncogene regulation, and transcriptional control.
  Herblot S, Chastagner P, Samady L, Moreau JL, Demaison C, Froussard P, Liu X, Bonnet J, Thèze J
  J Immunol. 1999
  PubMed ID: 10092780
   
  
• Immunosuppression through inhibition of interleukin-2/interleukin-2 receptor interaction.
  Soulillou JP
  Transplant Proc. 1999
  PubMed ID: 10078228
   
  
• On costimulatory signals and T cell tolerance: relevance for transplantation immunity.
  Holländer GA, Zuklys S, Förster E, Krenger W
  Transplant Proc. 1999
  PubMed ID: 10078224
   
  
• Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
  Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN
  Immunity. 1999
  PubMed ID: 10072077
   
  
• The kinetics of cytokine gene expression in the thyroids of mice developing granulomatous experimental autoimmune thyroiditis.
  Tang H, Sharp GC, Chen K, Braley-Mullen H
  J Autoimmun. 1998
  PubMed ID: 9878080
   
  
• Differential tropism and replication kinetics of human immunodeficiency virus type 1 isolates in thymocytes: coreceptor expression allows viral entry, but productive infection of distinct subsets is determined at the postentry level.
  Pedroza-Martins L, Gurney KB, Torbett BE, Uittenbogaart CH
  J Virol. 1998
  PubMed ID: 9811677
   
  
• Expression of Th1/Th2 cytokine mRNA in peritoneal exudative polymorphonuclear neutrophils and their effects on mononuclear cell Th1/Th2 cytokine production in MRL-lpr/lpr mice.
  Yu C, Sun K, Tsai C, Tsai Y, Tsai S, Huang D, Han S, Yu H
  Immunology. 1998
  PubMed ID: 9824514
   
  
• Primary Th1 cell immunization against HIVgp160 in SCID-hu mice coengrafted with peripheral blood lymphocytes and skin.
  Delhem N, Hadida F, Gorochov G, Carpentier F, de Cavel JP, Andréani JF, Autran B, Cesbron JY
  J Immunol. 1998
  PubMed ID: 9712080
   
  
• IL-2 receptor alpha-chain expression is independently regulated in primary and secondary lymphoid organs.
  Demaison C, Fiette L, Blanchetière V, Schimpl A, Thèze J, Froussard P
  J Immunol. 1998
  PubMed ID: 9712069
   
  
• Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.
  Dai Z, Konieczny BT, Baddoura FK, Lakkis FG
  J Immunol. 1998
  PubMed ID: 9712028
   
  
• Development of colonic adenocarcinomas in a mouse model of ulcerative colitis.
  Shah SA, Simpson SJ, Brown LF, Comiskey M, de Jong YP, Allen D, Terhorst C
  Inflamm Bowel Dis. 1998
  PubMed ID: 9741021
   
  
• Mice with a fluorescent marker for interleukin 2 gene activation.
  Naramura M, Hu RJ, Gu H
  Immunity. 1998
  PubMed ID: 9729041
   
  
• Genetic mapping of mouse transient receptor potential (Trrp) genes responsible for capacitative calcium entry channels to chromosomes 3, 7, 9, and X.
  Yamazaki K, Okada T, Mori Y, Tanaka I
  Genomics. 1998
  PubMed ID: 9722956
   
  
• CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.
  Su HC, Cousens LP, Fast LD, Slifka MK, Bungiro RD, Ahmed R, Biron CA
  J Immunol. 1998
  PubMed ID: 9590250
   
  
• Lymphokine regulation of activation-induced apoptosis in T cells of IL-2 and IL-2R beta knockout mice.
  Kung JT, Beller D, Ju ST
  Cell Immunol. 1998
  PubMed ID: 9636694
   
  
• Cytokine gene expression in murine fetal intestine: potential for extrathymic T cell development.
  Murray AM, Simm B, Beagley KW
  Cytokine. 1998
  PubMed ID: 9619371
   
  
• Bruton's tyrosine kinase-mediated interleukin-2 gene activation in mast cells. Dependence on the c-Jun N-terminal kinase activation pathway.
  Hata D, Kitaura J, Hartman SE, Kawakami Y, Yokota T, Kawakami T
  J Biol Chem. 1998
  PubMed ID: 9556577
   
  
• Abnormal myelocytic cell development in interleukin-2 (IL-2)-deficient mice: evidence for the involvement of IL-2 in myelopoiesis.
  Reya T, Contractor NV, Couzens MS, Wasik MA, Emerson SG, Carding SR
  Blood. 1998
  PubMed ID: 9531604
   
  
• Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency.
  Papiernik M, de Moraes ML, Pontoux C, Vasseur F, Pénit C
  Int Immunol. 1998
  PubMed ID: 9620592
   
  
• gp41 envelope protein of human immunodeficiency virus induces interleukin (IL)-10 in monocytes, but not in B, T, or NK cells, leading to reduced IL-2 and interferon-gamma production.
  Barcova M, Kacani L, Speth C, Dierich MP
  J Infect Dis. 1998
  PubMed ID: 9534962
   
  
• Monoallelic expression of the interleukin-2 locus.
  Holländer GA, Zuklys S, Morel C, Mizoguchi E, Mobisson K, Simpson S, Terhorst C, Wishart W, Golan DE, Bhan AK, Burakoff SJ
  Science. 1998
  PubMed ID: 9516115
   
  
• Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice.
  Stoffel B, Bauer P, Nix M, Deres K, Stoffel W
  Eur J Immunol. 1998
  PubMed ID: 9541582
   
  
• Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice.
  Meijssen MA, Brandwein SL, Reinecker HC, Bhan AK, Podolsky DK
  Am J Physiol. 1998
  PubMed ID: 9530147
   
  
• HIV p17 enhances lymphocyte proliferation and HIV-1 replication after binding to a human serum factor.
  De Francesco MA, Caruso A, Fallacara F, Canaris AD, Dima F, Poiesi C, Licenziati S, Corulli M, Martinelli F, Fiorentini S, Turano A
  AIDS. 1998
  PubMed ID: 9517986
   
  
• Altered antigen presentation in mice lacking H2-O.
  Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP, Karlsson L
  Immunity. 1998
  PubMed ID: 9492004
   
  
• Linkage mapping of Csrp to proximal mouse chromosome 3.
  Alli C, Consalez GG
  Mamm Genome. 1998
  PubMed ID: 9457685
   
  
• Genetic mapping of the mouse ferritin light chain gene and 11 pseudogenes on 11 mouse chromosomes.
  Filie JD, Buckler CE, Kozak CA
  Mamm Genome. 1998
  PubMed ID: 9457670
   
  
• Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.
  Reya T, Bassiri H, Biancaniello R, Carding SR
  Dev Immunol. 1998
  PubMed ID: 9814585
   
  
• Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice.
  Contractor NV, Bassiri H, Reya T, Park AY, Baumgart DC, Wasik MA, Emerson SG, Carding SR
  J Immunol. 1998
  PubMed ID: 9551995
   
  
• Interaction of STAT5 dimers on two low affinity binding sites mediates interleukin 2 (IL-2) stimulation of IL-2 receptor alpha gene transcription.
  Meyer WK, Reichenbach P, Schindler U, Soldaini E, Nabholz M
  J Biol Chem. 1997
  PubMed ID: 9395528
   
  
• Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation.
  Autenrieth IB, Bucheler N, Bohn E, Heinze G, Horak I
  Gut. 1997
  PubMed ID: 9462212
   
  
• Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation.
  Herold KC, Lu J, Rulifson I, Vezys V, Taub D, Grusby MJ, Bluestone JA
  J Immunol. 1997
  PubMed ID: 9379007
   
  
• Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.
  Boussiotis VA, Freeman GJ, Berezovskaya A, Barber DL, Nadler LM
  Science. 1997
  PubMed ID: 9311917
   
  
• Role of IL-2 in rat fetal thymocyte development.
  Varas A, Vicente A, Romo T, Zapata AG
  Int Immunol. 1997
  PubMed ID: 9352365
   
  
• Semi-quantitative polymerase chain reaction analysis of cytokine and cytokine receptor gene expression during thymic ontogeny.
  Montgomery RA, Dallman MJ
  Cytokine. 1997
  PubMed ID: 9344502
   
  
• HIV-1 Vpr suppresses immune activation and apoptosis through regulation of nuclear factor kappa B.
  Ayyavoo V, Mahboubi A, Mahalingam S, Ramalingam R, Kudchodkar S, Williams WV, Green DR, Weiner DB
  Nat Med. 1997
  PubMed ID: 9334723
   
  
• TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice.
  Lúdvíksson BR, Ehrhardt RO, Strober W
  J Immunol. 1997
  PubMed ID: 9317162
   
  
• GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
  Avots A, Hoffmeyer A, Flory E, Cimanis A, Rapp UR, Serfling E
  Mol Cell Biol. 1997
  PubMed ID: 9234696
   
  
• Modulation of Bcl-2 protein by CD4 cross-linking: a possible mechanism for lymphocyte apoptosis in human immunodeficiency virus infection and for rescue of apoptosis by interleukin-2.
  Hashimoto F, Oyaizu N, Kalyanaraman VS, Pahwa S
  Blood. 1997
  PubMed ID: 9226175
   
  
• Leukaemia inhibitory factor mRNA is expressed in the brains of patients with subacute sclerosing panencephalitis.
  McQuaid S, Campbell R, Isserte S, Cosby SL
  J Neuroimmunol. 1997
  PubMed ID: 9209269
   
  
• Stimulatory roles of muscarinic acetylcholine receptors on T cell antigen receptor/CD3 complex-mediated interleukin-2 production in human peripheral blood lymphocytes.
  Fujino H, Kitamura Y, Yada T, Uehara T, Nomura Y
  Mol Pharmacol. 1997
  PubMed ID: 9187267
   
  
• The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression.
  Li L, Krajewski S, Reed JC, Choi YS
  Cell Immunol. 1997
  PubMed ID: 9184696
   
  
• IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.
  Krulová M, Havelková H, Kosarová M, Holán V, Hart AA, Demant P, Lipoldová M
  Genomics. 1997
  PubMed ID: 9177770
   
  
• Immunosuppressive activity of cloned natural killer (NK1.1+) T cells established from murine tumor-infiltrating lymphocytes.
  Tamada K, Harada M, Abe K, Li T, Tada H, Onoe Y, Nomoto K
  J Immunol. 1997
  PubMed ID: 9144500
   
  
• Induction of autoimmune myocarditis in interleukin-2-deficient mice.
  Grässl G, Pummerer CL, Horak I, Neu N
  Circulation. 1997
  PubMed ID: 9107162
   
  
• Constitutive binding of the transcription factor interleukin-2 (IL-2) enhancer binding factor to the IL-2 promoter.
  Nirula A, Moore DJ, Gaynor RB
  J Biol Chem. 1997
  PubMed ID: 9065434
   
  
• Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway.
  Ott M, Emiliani S, Van Lint C, Herbein G, Lovett J, Chirmule N, McCloskey T, Pahwa S, Verdin E
  Science. 1997
  PubMed ID: 9045614
   
  
• Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner.
  Jin M, Uratani Y, Arimatsu Y
  Genomics. 1997
  PubMed ID: 9119386
   
  
• Different effects of IL-2 in vivo treatment and emotional stress on POMC gene expression in the pituitary of mice.
  Chesnokova V, Busick J, Chesnokov V, Jakobson G, Ivanova L
  Horm Metab Res. 1997
  PubMed ID: 9105908
   
  
• gp160 of HIV or anti-CD4 monoclonal antibody ligation of CD4 induces inhibition of JNK and ERK-2 activities in human peripheral CD4+ T lymphocytes.
  Jabado N, Pallier A, Jauliac S, Fischer A, Hivroz C
  Eur J Immunol. 1997
  PubMed ID: 9045910
   
  
• V3 loop of human immunodeficiency virus type 1 suppresses interleukin 2-induced T cell growth.
  Sakaida H, Murakami T, Kawamata S, Hattori T, Uchiyama T
  AIDS Res Hum Retroviruses. 1997
  PubMed ID: 9007200
   
  
• Induction and prevention of colonic inflammation in IL-2-deficient mice.
  Ehrhardt RO, Lúdvíksson BR, Gray B, Neurath M, Strober W
  J Immunol. 1997
  PubMed ID: 8992969
   
  
• Recombinant interleukin-2 acts as an adjuvant and helps to increase the efficacy of tumour vaccines.
  Vondrys P, Símová J, Takácová S, Jandlová T, Bubeník J
  Folia Biol (Praha). 1997
  PubMed ID: 9158948
   
  
• Absence of natural killer cells during murine pregnancy is associated with reproductive compromise in TgE26 mice.
  Guimond MJ, Luross JA, Wang B, Terhorst C, Danial S, Croy BA
  Biol Reprod. 1997
  PubMed ID: 9002646
   
  
• Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes.
  Lúdvíksson BR, Gray B, Strober W, Ehrhardt RO
  J Immunol. 1997
  PubMed ID: 8977180
   
  
• Decreased production of IL-2 and IFN-gamma by stimulated splenocytes from mice bearing plasma cell tumors is associated with alteration of DNA-binding factors.
  Ruzek MC, O'Brien DP, Mathur A
  Int Immunol. 1996
  PubMed ID: 8982782
   
  
• High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters.
  Himes SR, Coles LS, Reeves R, Shannon MF
  Immunity. 1996
  PubMed ID: 8934574
   
  
• Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions.
  Nishinakamura R, Miyajima A, Mee PJ, Tybulewicz VL, Murray R
  Blood. 1996
  PubMed ID: 8839836
   
  
• Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2.
  Gómez J, Martínez-A C, Fernández B, García A, Rebollo A
  J Immunol. 1996
  PubMed ID: 8805624
   
  
• In vivo expression of interleukin-1 beta (IL-1 beta), IL-2, IL-4, IL-6, tumour necrosis factor-alpha and interferon-gamma in the fetal murine thymus.
  Deman J, Van Meurs M, Claassen E, Humblet C, Boniver J, Defresne MP
  Immunology. 1996
  PubMed ID: 8911153
   
  
• Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells.
  Mondino A, Whaley CD, DeSilva DR, Li W, Jenkins MK, Mueller DL
  J Immunol. 1996
  PubMed ID: 8757326
   
  
• Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.
  Lundqvist C, Melgar S, Yeung MM, Hammarström S, Hammarström ML
  J Immunol. 1996
  PubMed ID: 8757311
   
  
• The effect of age on the expression of interleukin-2.
  Pahlavani MA, Richardson A
  Mech Ageing Dev. 1996
  PubMed ID: 8844635
   
  
• Characterization of Nef-induced CD4 T cell proliferation.
  Torres BA, Tanabe T, Johnson HM
  Biochem Biophys Res Commun. 1996
  PubMed ID: 8769094
   
  
• Evidence for intact CD28 signaling in T cell hyporesponsiveness induced by the HIV-1 nef gene.
  Collette Y, Mawas C, Olive D
  Eur J Immunol. 1996
  PubMed ID: 8765022
   
  
• Glutamine and tetrapeptide repeat variations affect the biological activity of different mouse interleukin-2 alleles.
  Matesanz F, Alcina A
  Eur J Immunol. 1996
  PubMed ID: 8765005
   
  
• Reversal of the inhibitory effects of HIV-gp120 on CD4+ T cells by stimulation through the CD28 pathway.
  Faith A, Yssel H, O'Hehir RE, Lamb JR
  Clin Exp Immunol. 1996
  PubMed ID: 8706326
   
  
• Chromosomal localization of murine and human oligodendrocyte-specific protein genes.
  Bronstein JM, Kozak CA, Chen XN, Wu S, Danciger M, Korenberg JR, Farber DB
  Genomics. 1996
  PubMed ID: 8661061
   
  
• Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.
  Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ
  Proc Natl Acad Sci U S A. 1996
  PubMed ID: 8643566
   
  
• Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation.
  Flores I, Casaseca T, Martinez-A C, Kanoh H, Merida I
  J Biol Chem. 1996
  PubMed ID: 8626603
   
  
• The specificity and orientation of a TCR to its peptide-MHC class II ligands.
  Sant'Angelo DB, Waterbury G, Preston-Hurlburt P, Yoon ST, Medzhitov R, Hong SC, Janeway CA
  Immunity. 1996
  PubMed ID: 8612131
   
  
• Sequence of interleukin-2 isolated from human placental poly A+ RNA: possible role in maintenance of fetal allograft.
  Chernicky CL, Tan H, Burfeind P, Ilan J, Ilan J
  Mol Reprod Dev. 1996
  PubMed ID: 8824916
   
  
• Mouse annexin V chromosomal localization, cDNA sequence conservation, and molecular evolution.
  Rodriguez-Garcia MI, Kozak CA, Morgan RO, Fernandez MP
  Genomics. 1996
  PubMed ID: 8824796
   
  
• Expression and co-cytokine function of murine thioredoxin/adult T cell leukaemia-derived factor (ADF).
  Blum H, Röllinghoff M, Gessner A
  Cytokine. 1996
  PubMed ID: 8742061
   
  
• Identical genetic control of MLC reactivity to different MHC incompatibilities, independent of production of and response to IL-2.
  Holán V, Lipoldová M, Demant P
  Immunogenetics. 1996
  PubMed ID: 8613140
   
  
• Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 Nef gene-induced expression.
  Collette Y, Chang HL, Cerdan C, Chambost H, Algarte M, Mawas C, Imbert J, Burny A, Olive D
  J Immunol. 1996
  PubMed ID: 8598486
   
  
• Regulated expression and function of CD122 (interleukin-2/interleukin-15R-beta) during lymphoid development.
  Reya T, Yang-Snyder JA, Rothenberg EV, Carding SR
  Blood. 1996
  PubMed ID: 8547641
   
  
• Erythropoietin-like activity in vivo of the fusion protein rhIL-6/IL-2 (CH925).
  Zhao C, Tang P, Mao N, Zhang S, Fan E, Dong B, Li Q, Du D
  Exp Hematol. 1996
  PubMed ID: 8536793
   
  
• Interleukin-2 deficient mice: a new model to study autoimmunity and self-tolerance.
  Horak I, Löhler J, Ma A, Smith KA
  Immunol Rev. 1995
  PubMed ID: 8825281
   
  
• CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine Th1 cells.
  Sommer F, Huber M, Röllinghoff M, Lohoff M
  Int Immunol. 1995
  PubMed ID: 8580076
   
  
• T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice.
  Ma A, Datta M, Margosian E, Chen J, Horak I
  J Exp Med. 1995
  PubMed ID: 7595226
   
  
• Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells.
  Sadlack B, Löhler J, Schorle H, Klebb G, Haber H, Sickel E, Noelle RJ, Horak I
  Eur J Immunol. 1995
  PubMed ID: 7489743
   
  
• Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.
  Munger W, DeJoy SQ, Jeyaseelan R, Torley LW, Grabstein KH, Eisenmann J, Paxton R, Cox T, Wick MM, Kerwar SS
  Cell Immunol. 1995
  PubMed ID: 7553894
   
  
• Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.
  Tuosto L, Piazza C, Moretti S, Modesti A, Greenlaw R, Lechler R, Lombardi G, Piccolella E
  Eur J Immunol. 1995
  PubMed ID: 7589092
   
  
• Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment.
  Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW
  Immunity. 1995
  PubMed ID: 7584142
   
  
• Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis.
  Simpson SJ, Mizoguchi E, Allen D, Bhan AK, Terhorst C
  Eur J Immunol. 1995
  PubMed ID: 7589135
   
  
• Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice.
  Kneitz B, Herrmann T, Yonehara S, Schimpl A
  Eur J Immunol. 1995
  PubMed ID: 7589128
   
  
• Immunodeficiency in IL-2-knockout mice.
  Horak I
  Clin Immunol Immunopathol. 1995
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• HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells.
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