Home RBPJ
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(Human) GRCh37 - chr4:26165077..26436752 (271.68 kb) View in Genome Browser
(Mouse) NCBIM37 - chr5:53947018..54048684 (101.67 kb) View in Genome Browser
(Rat) RGSC3.4 - chr5:4663785..4665505 (1.72 kb) View in Genome Browser
HaemAtlas Expression Table for RBPJ:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
| no data | no data | no data | no data | no data | ||||||||
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for RBPJ:The RBPJ interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| RBPJ | CREBBP | Reactome | predicted | |
| RBPJ | GADD45A | BioGRID | empirical | 21900206 |
| RBPJ | FHL1 | HPRD, MINT | empirical | 15710417 |
| RBPJ | SNW1 | HPRD, IntAct, MIPS, BioGRID, Reactome, Sanger Interaction Map | empirical | 10713164 11713164 10644367 15345047 |
| RBPJ | SPEN | HPRD, BioGRID | empirical | 12374742 |
| RBPJ | SIN3A | BioGRID | empirical | 10644367 |
| RBPJ | KAT2A | BioGRID | empirical | 10747963 |
| RBPJ | SND1 | HPRD, BioGRID | empirical | 7651391 10644367 9874765 |
| RBPJ | RPS6KA6 | BioGRID | empirical | 21900206 |
| RBPJ | GSK3B | BioGRID | empirical | 21900206 |
| RBPJ | HDAC1 | HPRD | empirical | 9694793 |
| RBPJ | HMGB1 | HPRD | empirical | 11748221 |
| RBPJ | KPNA4 | Sanger Interaction Map | predicted | 15345047 |
| RBPJ | ASAH1 | Sanger Interaction Map | predicted | 15345047 |
| RBPJ | MYC | IntAct | empirical | 21150319 |
| RBPJ | NOTCH1 | HPRD, IntAct, BioGRID, Reactome | empirical | 8749394 9111040 10637481 16530044 10713164 12644465 17210915 |
| RBPJ | NOTCH2 | HPRD, BioGRID, Reactome | empirical | 9032325 |
| RBPJ | NOTCH3 | HPRD, Reactome | empirical | 11404076 |
| RBPJ | NOTCH4 | HPRD, Reactome | empirical | 11518718 |
| RBPJ | SUFU | HPRD, BioGRID | empirical | 14611647 |
| RBPJ | POU5F1 | BioGRID | empirical | 20362541 |
| RBPJ | AGGF1 | Sanger Interaction Map | predicted | 15345047 |
| RBPJ | MAML3 | Reactome | predicted | |
| RBPJ | SMARCD3 | BioGRID | empirical | 17210915 |
| RBPJ | MAML2 | Reactome | predicted | |
| RBPJ | KAT2B | HPRD, BioGRID, Reactome | empirical | 10747963 |
| RBPJ | MED27 | IntAct | empirical | 21988832 |
| RBPJ | CIR1 | HPRD, IntAct, BioGRID | empirical | 9874765 |
| RBPJ | NCOR1 | HPRD | empirical | 9694793 |
| RBPJ | NCOR2 | HPRD, IntAct | empirical | 11509665 10713164 |
| RBPJ | MAML1 | HPRD, IntAct, Reactome | empirical | 16530044 |
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Type 1 Diabetes Publications: 4
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Conditional ablation of Notch signaling in pancreatic development.
Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM
Development. 2008
PubMed ID: 18635610
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Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to Area III.
Miyatsuka T, Matsuoka TA, Shiraiwa T, Yamamoto T, Kojima I, Kaneto H
Biochem Biophys Res Commun. 2007
PubMed ID: 17803961
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Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ
Genes Dev. 2007
PubMed ID: 17938243
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Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K
Cell Metab. 2006
PubMed ID: 16399505
Publications: 294
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Notch pathway regulation of neural crest cell development in vivo.
Mead TJ, Yutzey KE
Dev Dyn. 2012
PubMed ID: 22275227
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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch.
Lee JS, Cella M, McDonald KG, Garlanda C, Kennedy GD, Nukaya M, Mantovani A, Kopan R, Bradfield CA, Newberry RD, Colonna M
Nat Immunol. 2012
PubMed ID: 22101730
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Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo.
Vanderpool C, Sparks EE, Huppert KA, Gannon M, Means AL, Huppert SS
Hepatology. 2012
PubMed ID: 21898486
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Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.
Lewis KL, Caton ML, Bogunovic M, Greter M, Grajkowska LT, Ng D, Klinakis A, Charo IF, Jung S, Gommerman JL, Ivanov II, Liu K, Merad M, Reizis B
Immunity. 2011
PubMed ID: 22018469
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Kaposi's sarcoma-associated herpesvirus Rta tetramers make high-affinity interactions with repetitive DNA elements in the Mta promoter to stimulate DNA binding of RBP-Jk/CSL.
Palmeri D, Carroll KD, Gonzalez-Lopez O, Lukac DM
J Virol. 2011
PubMed ID: 21880753
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Notch post-translationally regulates β-catenin protein in stem and progenitor cells.
Kwon C, Cheng P, King IN, Andersen P, Shenje L, Nigam V, Srivastava D
Nat Cell Biol. 2011
PubMed ID: 21841793
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Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.
Castellanos Rivera RM, Monteagudo MC, Pentz ES, Glenn ST, Gross KW, Carretero O, Sequeira-Lopez ML, Gomez RA
Physiol Genomics. 2011
PubMed ID: 21750232
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A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
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Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.
Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21737748
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Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism.
Wu X, Xu K, Zhang L, Deng Y, Lee P, Shapiro E, Monaco M, Makarenkova HP, Li J, Lepor H, Grishina I
Dev Biol. 2011
PubMed ID: 21624358
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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Pajvani UB, Shawber CJ, Samuel VT, Birkenfeld AL, Shulman GI, Kitajewski J, Accili D
Nat Med. 2011
PubMed ID: 21804540
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Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.
Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KM, Wang IJ, Kaartinen V, Yang LT, Cardoso WV
Development. 2011
PubMed ID: 21791528
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Loss of Gata5 in mice leads to bicuspid aortic valve.
Laforest B, Andelfinger G, Nemer M
J Clin Invest. 2011
PubMed ID: 21633169
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The single RBP-Jkappa site within the LANA promoter is crucial for establishing Kaposi's sarcoma-associated herpesvirus latency during primary infection.
Lu J, Verma SC, Cai Q, Robertson ES
J Virol. 2011
PubMed ID: 21507979
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Diet-induced aortic valve disease in mice haploinsufficient for the Notch pathway effector RBPJK/CSL.
Nus M, MacGrogan D, Martínez-Poveda B, Benito Y, Casanova JC, Fernández-Avilés F, Bermejo J, de la Pompa JL
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 21493891
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NKAP is required for T cell maturation and acquisition of functional competency.
Hsu FC, Pajerowski AG, Nelson-Holte M, Sundsbak R, Shapiro VS
J Exp Med. 2011
PubMed ID: 21624937
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Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa.
Basch ML, Ohyama T, Segil N, Groves AK
J Neurosci. 2011
PubMed ID: 21632926
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Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk.
Kim MY, Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim SM, Kim HY, Ahn JS, Kim H, Kim K, Hoe HS, Park HS
J Cell Sci. 2011
PubMed ID: 21558417
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RBP-J promotes the maturation of neuronal progenitors.
Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K
Dev Biol. 2011
PubMed ID: 21443869
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Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth.
Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E
Virology. 2011
PubMed ID: 21440926
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Rbpj regulates development of prosensory cells in the mammalian inner ear.
Yamamoto N, Chang W, Kelley MW
Dev Biol. 2011
PubMed ID: 21420948
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EBV nuclear antigen EBNALP dismisses transcription repressors NCoR and RBPJ from enhancers and EBNA2 increases NCoR-deficient RBPJ DNA binding.
Portal D, Zhao B, Calderwood MA, Sommermann T, Johannsen E, Kieff E
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21518914
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Notch signaling regulates the development of a novel type of Thy1-expressing dendritic cell in the thymus.
Ishifune C, Maekawa Y, Nishida J, Kitamura A, Tanigaki K, Yagita H, Yasutomo K
Eur J Immunol. 2011
PubMed ID: 21469122
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Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice.
Sparks EE, Perrien DS, Huppert KA, Peterson TE, Huppert SS
Dis Model Mech. 2011
PubMed ID: 21282722
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Transcriptional repression in the Notch pathway: thermodynamic characterization of CSL-MINT (Msx2-interacting nuclear target protein) complexes.
VanderWielen BD, Yuan Z, Friedmann DR, Kovall RA
J Biol Chem. 2011
PubMed ID: 21372128
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Notch signaling in stomach epithelial stem cell homeostasis.
Kim TH, Shivdasani RA
J Exp Med. 2011
PubMed ID: 21402740
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Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Pérez-Pomares JM, de la Pompa JL
Circ Res. 2011
PubMed ID: 21311046
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Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression.
Kim TH, Shivdasani RA
J Biol Chem. 2011
PubMed ID: 21282114
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Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch.
Li F, Lan Y, Wang Y, Wang J, Yang G, Meng F, Han H, Meng A, Wang Y, Yang X
Dev Cell. 2011
PubMed ID: 21397841
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Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice.
Fu T, Zhang P, Feng L, Ji G, Wang XH, Zheng MH, Qin HY, Chen DL, Wang WZ, Han H
Mol Immunol. 2011
PubMed ID: 21168915
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RBP-Jκ-dependent Notch signaling enhances retinal pigment epithelial cell proliferation in transgenic mice.
Schouwey K, Aydin IT, Radtke F, Beermann F
Oncogene. 2011
PubMed ID: 20856205
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Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.
Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I
Blood. 2011
PubMed ID: 20870902
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Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.
Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI
J Clin Invest. 2011
PubMed ID: 21123947
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A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.
Bartels SJ, Spruijt CG, Brinkman AB, Jansen PW, Vermeulen M, Stunnenberg HG
PLoS One. 2011
PubMed ID: 21991380
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Notch, IL-1 and leptin crosstalk outcome (NILCO) is critical for leptin-induced proliferation, migration and VEGF/VEGFR-2 expression in breast cancer.
Guo S, Gonzalez-Perez RR
PLoS One. 2011
PubMed ID: 21731759
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Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
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Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis.
Hamidi H, Gustafason D, Pellegrini M, Gasson J
PLoS One. 2011
PubMed ID: 21637838
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The role of the transcription factor Rbpj in the development of dorsal root ganglia.
Hu ZL, Shi M, Huang Y, Zheng MH, Pei Z, Chen JY, Han H, Ding YQ
Neural Dev. 2011
PubMed ID: 21510873
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Notch signaling regulates remodeling and vessel diameter in the extraembryonic yolk sac.
Copeland JN, Feng Y, Neradugomma NK, Fields PE, Vivian JL
BMC Dev Biol. 2011
PubMed ID: 21352545
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Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.
Jeannet R, Mastio J, Macias-Garcia A, Oravecz A, Ashworth T, Geimer Le Lay AS, Jost B, Le Gras S, Ghysdael J, Gridley T, Honjo T, Radtke F, Aster JC, Chan S, Kastner P
Blood. 2010
PubMed ID: 20829372
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EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Nomura T, Göritz C, Catchpole T, Henkemeyer M, Frisén J
Cell Stem Cell. 2010
PubMed ID: 21112567
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Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.
Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K
Immunity. 2010
PubMed ID: 21093322
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RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
Wacker SA, Alvarado C, von Wichert G, Knippschild U, Wiedenmann J, Clauß K, Nienhaus GU, Hameister H, Baumann B, Borggrefe T, Knöchel W, Oswald F
EMBO J. 2010
PubMed ID: 21102556
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Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.
Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K
J Clin Invest. 2010
PubMed ID: 20978353
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Cutting edge: Thymic NK cells develop independently from T cell precursors.
Ribeiro VS, Hasan M, Wilson A, Boucontet L, Pereira P, Lesjean-Pottier S, Satoh-Takayama N, Di Santo JP, Vosshenrich CA
J Immunol. 2010
PubMed ID: 20889548
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Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, Li Y, Hu X, Ivashkiv LB
J Immunol. 2010
PubMed ID: 20870935
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Most common SNPs associated with rheumatoid arthritis in subjects of European ancestry confer risk of rheumatoid arthritis in African-Americans.
Hughes LB, Reynolds RJ, Brown EE, Kelley JM, Thomson B, Conn DL, Jonas BL, Westfall AO, Padilla MA, Callahan LF, Smith EA, Brasington RD, Edberg JC, Kimberly RP, Moreland LW, Plenge RM, Bridges SL
Arthritis Rheum. 2010
PubMed ID: 20973039
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RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.
Ehm O, Göritz C, Covic M, Schäffner I, Schwarz TJ, Karaca E, Kempkes B, Kremmer E, Pfrieger FW, Espinosa L, Bigas A, Giachino C, Taylor V, Frisén J, Lie DC
J Neurosci. 2010
PubMed ID: 20943920
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Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation.
Luna-Zurita L, Prados B, Grego-Bessa J, Luxán G, del Monte G, Benguría A, Adams RH, Pérez-Pomares JM, de la Pompa JL
J Clin Invest. 2010
PubMed ID: 20890042
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Osteogenic differentiation of mouse mesenchymal progenitor cell, Kusa-A1 is promoted by mammalian transcriptional repressor Rbpj.
Wang S, Kawashima N, Sakamoto K, Katsube K, Umezawa A, Suda H
Biochem Biophys Res Commun. 2010
PubMed ID: 20691157
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ChIP (chromatin immunoprecipitation) analysis demonstrates co-ordinated binding of two transcription factors to the promoter of the p53 tumour-suppressor gene.
Polson A, Takahashi P, Reisman D
Cell Biol Int. 2010
PubMed ID: 20446924
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Regulation of myeloid leukaemia by the cell-fate determinant Musashi.
Ito T, Kwon HY, Zimdahl B, Congdon KL, Blum J, Lento WE, Zhao C, Lagoo A, Gerrard G, Foroni L, Goldman J, Goh H, Kim SH, Kim DW, Chuah C, Oehler VG, Radich JP, Jordan CT, Reya T
Nature. 2010
PubMed ID: 20639863
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Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis.
Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP
Genes Dev. 2010
PubMed ID: 20634318
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Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-Jkappa in Ikaros null mice.
Chari S, Umetsu SE, Winandy S
J Immunol. 2010
PubMed ID: 20511547
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Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.
Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsässer HP, Magnuson MA, MacDonald RJ
Gastroenterology. 2010
PubMed ID: 20398665
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Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
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Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma.
Julian E, Dave RK, Robson JP, Hallahan AR, Wainwright BJ
Oncogene. 2010
PubMed ID: 20418906
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Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses.
Wang YC, He F, Feng F, Liu XW, Dong GY, Qin HY, Hu XB, Zheng MH, Liang L, Feng L, Liang YM, Han H
Cancer Res. 2010
PubMed ID: 20501839
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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nat Genet. 2010
PubMed ID: 20453842
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Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging.
Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Götz M, Haas CA, Kempermann G, Taylor V, Giachino C
Cell Stem Cell. 2010
PubMed ID: 20452319
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RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.
Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ
Development. 2010
PubMed ID: 20335360
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Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
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An Oct4-centered protein interaction network in embryonic stem cells.
van den Berg DL, Snoek T, Mullin NP, Yates A, Bezstarosti K, Demmers J, Chambers I, Poot RA
Cell Stem Cell. 2010
PubMed ID: 20362541
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The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells.
Srinivasan RS, Geng X, Yang Y, Wang Y, Mukatira S, Studer M, Porto MP, Lagutin O, Oliver G
Genes Dev. 2010
PubMed ID: 20360386
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Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor.
Alam MS, Maekawa Y, Kitamura A, Tanigaki K, Yoshimoto T, Kishihara K, Yasutomo K
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20231432
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Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
Roberts KE, Kawut SM, Krowka MJ, Brown RS, Trotter JF, Shah V, Peter I, Tighiouart H, Mitra N, Handorf E, Knowles JA, Zacks S, Fallon MB, Pulmonary Vascular Complications of Liver Disease Study Group
Gastroenterology. 2010
PubMed ID: 20346360
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Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex.
Liefke R, Oswald F, Alvarado C, Ferres-Marco D, Mittler G, Rodriguez P, Dominguez M, Borggrefe T
Genes Dev. 2010
PubMed ID: 20231316
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Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains.
Imayoshi I, Sakamoto M, Yamaguchi M, Mori K, Kageyama R
J Neurosci. 2010
PubMed ID: 20203209
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Binding of RBP-Jkappa (CSL) protein to the promoter of the Kaposi's sarcoma-associated herpesvirus ORF47 (gL) gene is a critical but not sufficient determinant of transactivation by ORF50 protein.
Chang PJ, Boonsiri J, Wang SS, Chen LY, Miller G
Virology. 2010
PubMed ID: 20006367
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Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2.
Johnson SE, Ilagan MX, Kopan R, Barrick D
J Biol Chem. 2010
PubMed ID: 20028974
-
Asymmetric Arginine dimethylation of Epstein-Barr virus nuclear antigen 2 promotes DNA targeting.
Gross H, Barth S, Palermo RD, Mamiani A, Hennard C, Zimber-Strobl U, West MJ, Kremmer E, Grässer FA
Virology. 2010
PubMed ID: 19969318
-
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.
Hu M, Sun XJ, Zhang YL, Kuang Y, Hu CQ, Wu WL, Shen SH, Du TT, Li H, He F, Xiao HS, Wang ZG, Liu TX, Lu H, Huang QH, Chen SJ, Chen Z
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133625
-
Transgenic expression of Notch in melanocytes demonstrates RBP-Jkappa-dependent signaling.
Schouwey K, Larue L, Radtke F, Delmas V, Beermann F
Pigment Cell Melanoma Res. 2010
PubMed ID: 19895548
-
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate.
Morimoto M, Liu Z, Cheng HT, Winters N, Bader D, Kopan R
J Cell Sci. 2010
PubMed ID: 20048339
-
Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.
Kassner N, Krueger M, Yagita H, Dzionek A, Hutloff A, Kroczek R, Scheffold A, Rutz S
J Immunol. 2010
PubMed ID: 20008296
-
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage.
Surendran K, Boyle S, Barak H, Kim M, Stomberski C, McCright B, Kopan R
Dev Biol. 2010
PubMed ID: 19914235
-
Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.
Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L
Oncogene. 2010
PubMed ID: 19838210
-
RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer.
Julian E, Hallahan AR, Wainwright BJ
Neural Dev. 2010
PubMed ID: 20950430
-
The transcription factor RBP-J-mediated signaling is essential for dendritic cells to evoke efficient anti-tumor immune responses in mice.
Feng F, Wang YC, Hu XB, Liu XW, Ji G, Chen YR, Wang L, He F, Dou GR, Liang L, Zhang HW, Han H
Mol Cancer. 2010
PubMed ID: 20420708
-
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of notch signaling in the murine skin.
Dumortier A, Durham AD, Di Piazza M, Vauclair S, Koch U, Ferrand G, Ferrero I, Demehri S, Song LL, Farr AG, Leonard WJ, Kopan R, Miele L, Hohl D, Finke D, Radtke F
PLoS One. 2010
PubMed ID: 20174635
-
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis.
Xu K, Nieuwenhuis E, Cohen BL, Wang W, Canty AJ, Danska JS, Coultas L, Rossant J, Wu MY, Piscione TD, Nagy A, Gossler A, Hicks GG, Hui CC, Henkelman RM, Yu LX, Sled JG, Gridley T, Egan SE
Am J Physiol Lung Cell Mol Physiol. 2010
PubMed ID: 19897741
-
A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
-
Epstein-Barr virus nuclear protein 3C domains necessary for lymphoblastoid cell growth: interaction with RBP-Jkappa regulates TCL1.
Lee S, Sakakibara S, Maruo S, Zhao B, Calderwood MA, Holthaus AM, Lai CY, Takada K, Kieff E, Johannsen E
J Virol. 2009
PubMed ID: 19776126
-
Rbpj cell autonomous regulation of retinal ganglion cell and cone photoreceptor fates in the mouse retina.
Riesenberg AN, Liu Z, Kopan R, Brown NL
J Neurosci. 2009
PubMed ID: 19828801
-
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M
PLoS Genet. 2009
PubMed ID: 19779553
-
Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.
Henke RM, Savage TK, Meredith DM, Glasgow SM, Hori K, Dumas J, MacDonald RJ, Johnson JE
Development. 2009
PubMed ID: 19641016
-
Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development.
Mead TJ, Yutzey KE
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19590010
-
Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.
Chen H, Ko G, Zatti A, Di Giacomo G, Liu L, Raiteri E, Perucco E, Collesi C, Min W, Zeiss C, De Camilli P, Cremona O
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666558
-
RBP-J promotes neuronal differentiation and inhibits oligodendroglial development in adult neurogenesis.
Fujimoto M, Takagi Y, Muraki K, Nozaki K, Yamamoto N, Tsuji M, Hashimoto N, Honjo T, Tanigaki K
Dev Biol. 2009
PubMed ID: 19501584
-
Cell- and stage-specific chromatin structure across the Complement receptor 2 (CR2/CD21) promoter coincide with CBF1 and C/EBP-beta binding in B cells.
Cruickshank MN, Fenwick E, Karimi M, Abraham LJ, Ulgiati D
Mol Immunol. 2009
PubMed ID: 19487031
-
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
Gut. 2009
PubMed ID: 19240061
-
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment.
Demehri S, Turkoz A, Kopan R
Cancer Cell. 2009
PubMed ID: 19573812
-
Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.
Iulianella A, Sharma M, Vanden Heuvel GB, Trainor PA
Development. 2009
PubMed ID: 19542352
-
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity.
Woodhoo A, Alonso MB, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P, Shen J, Guillemot F, Radtke F, Meijer D, Feltri ML, Wrabetz L, Mirsky R, Jessen KR
Nat Neurosci. 2009
PubMed ID: 19525946
-
Notch signaling controls the balance of ciliated and secretory cell fates in developing airways.
Tsao PN, Vasconcelos M, Izvolsky KI, Qian J, Lu J, Cardoso WV
Development. 2009
PubMed ID: 19502490
-
Lipopolysaccharide-induced maturation of bone marrow-derived dendritic cells is regulated by notch signaling through the up-regulation of CXCR4.
Wang YC, Hu XB, He F, Feng F, Wang L, Li W, Zhang P, Li D, Jia ZS, Liang YM, Han H
J Biol Chem. 2009
PubMed ID: 19357083
-
Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma.
Demehri S, Morimoto M, Holtzman MJ, Kopan R
PLoS Biol. 2009
PubMed ID: 19557146
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Notch signaling controls liver development by regulating biliary differentiation.
Zong Y, Panikkar A, Xu J, Antoniou A, Raynaud P, Lemaigre F, Stanger BZ
Development. 2009
PubMed ID: 19369401
-
Jagged 1 is necessary for normal mouse lens formation.
Le TT, Conley KW, Brown NL
Dev Biol. 2009
PubMed ID: 19389370
-
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model.
Mercher T, Raffel GD, Moore SA, Cornejo MG, Baudry-Bluteau D, Cagnard N, Jesneck JL, Pikman Y, Cullen D, Williams IR, Akashi K, Shigematsu H, Bourquin JP, Giovannini M, Vainchenker W, Levine RL, Lee BH, Bernard OA, Gilliland DG
J Clin Invest. 2009
PubMed ID: 19287095
-
Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors.
Gao F, Zhang Q, Zheng MH, Liu HL, Hu YY, Zhang P, Zhang ZP, Qin HY, Feng L, Wang L, Han H, Ju G
Mol Cell Neurosci. 2009
PubMed ID: 19168137
-
Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth.
Maruo S, Wu Y, Ito T, Kanda T, Kieff ED, Takada K
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19237563
-
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MS, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisén J
Nat Neurosci. 2009
PubMed ID: 19234458
-
Notch signaling in bulge stem cells is not required for selection of hair follicle fate.
Demehri S, Kopan R
Development. 2009
PubMed ID: 19211676
-
RBP-Jkappa binds to and represses transcription of the p53 tumor suppressor gene.
Boggs K, Henderson B, Reisman D
Cell Biol Int. 2009
PubMed ID: 19135161
-
Senescent stromal-derived osteopontin promotes preneoplastic cell growth.
Pazolli E, Luo X, Brehm S, Carbery K, Chung JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA
Cancer Res. 2009
PubMed ID: 19155301
-
Reduced notch activity is associated with an impaired marginal zone B cell development and function in Sly1 mutant mice.
Scheikl T, Reis B, Pfeffer K, Holzmann B, Beer S
Mol Immunol. 2009
PubMed ID: 18950867
-
Tenascin-C is a novel RBPJkappa-induced target gene for Notch signaling in gliomas.
Sivasankaran B, Degen M, Ghaffari A, Hegi ME, Hamou MF, Ionescu MC, Zweifel C, Tolnay M, Wasner M, Mergenthaler S, Miserez AR, Kiss R, Lino MM, Merlo A, Chiquet-Ehrismann R, Boulay JL
Cancer Res. 2009
PubMed ID: 19147558
-
Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis.
Raafat A, Lawson S, Bargo S, Klauzinska M, Strizzi L, Goldhar AS, Buono K, Salomon D, Vonderhaar BK, Callahan R
Oncogene. 2009
PubMed ID: 18836481
-
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.
Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, Kageyama R, Wallace VA
J Cell Biol. 2009
PubMed ID: 19124651
-
The transcription factor RBP-J is essential for retinal cell differentiation and lamination.
Zheng MH, Shi M, Pei Z, Gao F, Han H, Ding YQ
Mol Brain. 2009
PubMed ID: 20017954
-
Notch-RBP-J signaling regulates the mobilization and function of endothelial progenitor cells by dynamic modulation of CXCR4 expression in mice.
Wang L, Wang YC, Hu XB, Zhang BF, Dou GR, He F, Gao F, Feng F, Liang YM, Dou KF, Han H
PLoS One. 2009
PubMed ID: 19859544
-
Functional characterization and identification of mouse Rad51d splice variants.
Gruver AM, Yard BD, McInnes C, Rajesh C, Pittman DL
BMC Mol Biol. 2009
PubMed ID: 19327148
-
"Notch-Off": a perspective on the termination of Notch signalling.
Fior R, Henrique D
Int J Dev Biol. 2009
PubMed ID: 19247952
-
Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti.
Doetzlhofer A, Basch ML, Ohyama T, Gessler M, Groves AK, Segil N
Dev Cell. 2009
PubMed ID: 19154718
-
Blockade of Notch signaling in tumor-bearing mice may lead to tumor regression, progression, or metastasis, depending on tumor cell types.
Hu XB, Feng F, Wang YC, Wang L, He F, Dou GR, Liang L, Zhang HW, Liang YM, Han H
Neoplasia. 2009
PubMed ID: 19107229
-
Disruption of the transcription factor recombination signal-binding protein-Jkappa (RBP-J) leads to veno-occlusive disease and interfered liver regeneration in mice.
Wang L, Wang CM, Hou LH, Dou GR, Wang YC, Hu XB, He F, Feng F, Zhang HW, Liang YM, Dou KF, Han H
Hepatology. 2009
PubMed ID: 19065680
-
Notch signaling regulates the FOXP3 promoter through RBP-J- and Hes1-dependent mechanisms.
Ou-Yang HF, Zhang HW, Wu CG, Zhang P, Zhang J, Li JC, Hou LH, He F, Ti XY, Song LQ, Zhang SZ, Feng L, Qi HW, Han H
Mol Cell Biochem. 2009
PubMed ID: 18777163
-
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells.
Shimizu T, Kagawa T, Inoue T, Nonaka A, Takada S, Aburatani H, Taga T
Mol Cell Biol. 2008
PubMed ID: 18852283
-
KyoT3, an isoform of murine FHL1, associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation.
Liang L, Zhang HW, Liang J, Niu XL, Zhang SZ, Feng L, Liang YM, Han H
Biochim Biophys Acta. 2008
PubMed ID: 18760388
-
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Hu X, Chung AY, Wu I, Foldi J, Chen J, Ji JD, Tateya T, Kang YJ, Han J, Gessler M, Kageyama R, Ivashkiv LB
Immunity. 2008
PubMed ID: 18976936
-
Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles.
Aubin-Houzelstein G, Djian-Zaouche J, Bernex F, Gadin S, Delmas V, Larue L, Panthier JJ
J Invest Dermatol. 2008
PubMed ID: 18463680
-
Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element.
Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES, Lan K
Virology. 2008
PubMed ID: 18786687
-
Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.
Tsao PN, Chen F, Izvolsky KI, Walker J, Kukuruzinska MA, Lu J, Cardoso WV
J Biol Chem. 2008
PubMed ID: 18694942
-
Notch activates cell cycle reentry and progression in quiescent cardiomyocytes.
Campa VM, Gutiérrez-Lanza R, Cerignoli F, Díaz-Trelles R, Nelson B, Tsuji T, Barcova M, Jiang W, Mercola M
J Cell Biol. 2008
PubMed ID: 18838555
-
AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.
Wang X, Pasolli HA, Williams T, Fuchs E
J Cell Biol. 2008
PubMed ID: 18824566
-
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
-
Notch signaling regulates growth and differentiation in the mammalian lens.
Rowan S, Conley KW, Le TT, Donner AL, Maas RL, Brown NL
Dev Biol. 2008
PubMed ID: 18588871
-
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.
Imayoshi I, Shimogori T, Ohtsuka T, Kageyama R
Development. 2008
PubMed ID: 18579678
-
Pofut1 is required for the proper localization of the Notch receptor during mouse development.
Okamura Y, Saga Y
Mech Dev. 2008
PubMed ID: 18547789
-
Slug is a direct Notch target required for initiation of cardiac cushion cellularization.
Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A
J Cell Biol. 2008
PubMed ID: 18663143
-
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode.
Jayasena CS, Ohyama T, Segil N, Groves AK
Development. 2008
PubMed ID: 18495817
-
Ectopic notch activation in developing podocytes causes glomerulosclerosis.
Waters AM, Wu MY, Onay T, Scutaru J, Liu J, Lobe CG, Quaggin SE, Piscione TD
J Am Soc Nephrol. 2008
PubMed ID: 18337488
-
Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity.
Demehri S, Liu Z, Lee J, Lin MH, Crosby SD, Roberts CJ, Grigsby PW, Miner JH, Farr AG, Kopan R
PLoS Biol. 2008
PubMed ID: 18507503
-
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.
Friedmann DR, Wilson JJ, Kovall RA
J Biol Chem. 2008
PubMed ID: 18381292
-
SoxB1 transcription factors and Notch signaling use distinct mechanisms to regulate proneural gene function and neural progenitor differentiation.
Holmberg J, Hansson E, Malewicz M, Sandberg M, Perlmann T, Lendahl U, Muhr J
Development. 2008
PubMed ID: 18417619
-
ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.
Salat D, Liefke R, Wiedenmann J, Borggrefe T, Oswald F
Mol Cell Biol. 2008
PubMed ID: 18332109
-
RBP-J, the transcription factor downstream of Notch receptors, is essential for the maintenance of vascular homeostasis in adult mice.
Dou GR, Wang YC, Hu XB, Hou LH, Wang CM, Xu JF, Wang YS, Liang YM, Yao LB, Yang AG, Han H
FASEB J. 2008
PubMed ID: 18096813
-
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.
Kathrein KL, Chari S, Winandy S
J Biol Chem. 2008
PubMed ID: 18287091
-
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells.
Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS
Cell Stem Cell. 2008
PubMed ID: 18397755
-
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
-
Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site.
Tang Y, Urs S, Liaw L
Circ Res. 2008
PubMed ID: 18239137
-
Mutational and energetic studies of Notch 1 transcription complexes.
Del Bianco C, Aster JC, Blacklow SC
J Mol Biol. 2008
PubMed ID: 18155729
-
A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.
Hori K, Cholewa-Waclaw J, Nakada Y, Glasgow SM, Masui T, Henke RM, Wildner H, Martarelli B, Beres TM, Epstein JA, Magnuson MA, Macdonald RJ, Birchmeier C, Johnson JE
Genes Dev. 2008
PubMed ID: 18198335
-
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition.
Ong CT, Sedy JR, Murphy KM, Kopan R
PLoS ONE. 2008
PubMed ID: 18665263
-
Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.
Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Alborán IM, Nakayama K, Nakayama KI
J Exp Med. 2007
PubMed ID: 17984302
-
The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling.
Komine O, Nagaoka M, Watase K, Gutmann DH, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K
Dev Biol. 2007
PubMed ID: 17915208
-
Rbp-j regulates expansion of pancreatic epithelial cells and their differentiation into exocrine cells during mouse development.
Fujikura J, Hosoda K, Kawaguchi Y, Noguchi M, Iwakura H, Odori S, Mori E, Tomita T, Hirata M, Ebihara K, Masuzaki H, Fukuda A, Furuyama K, Tanigaki K, Yabe D, Nakao K
Dev Dyn. 2007
PubMed ID: 17849436
-
The Notch signaling pathway controls the size of the ocular lens by directly suppressing p57Kip2 expression.
Jia J, Lin M, Zhang L, York JP, Zhang P
Mol Cell Biol. 2007
PubMed ID: 17709399
-
Zinc-induced downregulation of Notch signaling is associated with cytoplasmic retention of Notch1-IC and RBP-Jk via PI3k-Akt signaling pathway.
Baek SH, Kim MY, Mo JS, Ann EJ, Lee KS, Park JH, Kim JY, Seo MS, Choi EJ, Park HS
Cancer Lett. 2007
PubMed ID: 17513037
-
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
Laky K, Fowlkes BJ
J Exp Med. 2007
PubMed ID: 17698590
-
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
-
The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1.
Liao WR, Hsieh RH, Hsu KW, Wu MZ, Tseng MJ, Mai RT, Wu Lee YH, Yeh TS
Carcinogenesis. 2007
PubMed ID: 17434929
-
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.
Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R
Dev Cell. 2007
PubMed ID: 17681139
-
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.
Caton ML, Smith-Raska MR, Reizis B
J Exp Med. 2007
PubMed ID: 17591855
-
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch.
Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, Busslinger M, McCright B, Gridley T, Flavell RA
Immunity. 2007
PubMed ID: 17658279
-
Notch directly regulates Gata3 expression during T helper 2 cell differentiation.
Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS
Immunity. 2007
PubMed ID: 17658278
-
Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems.
Taylor MK, Yeager K, Morrison SJ
Development. 2007
PubMed ID: 17537790
-
The notch pathway positively regulates programmed cell death during erythroid differentiation.
Robert-Moreno A, Espinosa L, Sanchez MJ, de la Pompa JL, Bigas A
Leukemia. 2007
PubMed ID: 17476283
-
A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter.
Singh PP, Voleti B, Agrawal A
J Immunol. 2007
PubMed ID: 17513780
-
Generation of a conditional knockout allele for mammalian Spen protein Mint/SHARP.
Yabe D, Fukuda H, Aoki M, Yamada S, Takebayashi S, Shinkura R, Yamamoto N, Honjo T
Genesis. 2007
PubMed ID: 17457934
-
Opposing LSD1 complexes function in developmental gene activation and repression programmes.
Wang J, Scully K, Zhu X, Cai L, Zhang J, Prefontaine GG, Krones A, Ohgi KA, Zhu P, Garcia-Bassets I, Liu F, Taylor H, Lozach J, Jayes FL, Korach KS, Glass CK, Fu XD, Rosenfeld MG
Nature. 2007
PubMed ID: 17392792
-
Rbm15 modulates Notch-induced transcriptional activation and affects myeloid differentiation.
Ma X, Renda MJ, Wang L, Cheng EC, Niu C, Morris SW, Chi AS, Krause DS
Mol Cell Biol. 2007
PubMed ID: 17283045
-
RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.
Vasyutina E, Lenhard DC, Wende H, Erdmann B, Epstein JA, Birchmeier C
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360543
-
Notch signaling is essential for ventricular chamber development.
Grego-Bessa J, Luna-Zurita L, del Monte G, Bolós V, Melgar P, Arandilla A, Garratt AN, Zang H, Mukouyama YS, Chen H, Shou W, Ballestar E, Esteller M, Rojas A, Pérez-Pomares JM, de la Pompa JL
Dev Cell. 2007
PubMed ID: 17336907
-
Essential role of RBP-Jkappa in activation of the K8 delayed-early promoter of Kaposi's sarcoma-associated herpesvirus by ORF50/RTA.
Wang Y, Yuan Y
Virology. 2007
PubMed ID: 17055026
-
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.
Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17284587
-
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.
Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R
Development. 2007
PubMed ID: 17229764
-
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis.
Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA
Cell Death Differ. 2007
PubMed ID: 16763620
-
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Tsuji M, Shinkura R, Kuroda K, Yabe D, Honjo T
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17242367
-
Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch.
Lubman OY, Ilagan MX, Kopan R, Barrick D
J Mol Biol. 2007
PubMed ID: 17070841
-
Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry.
Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17210915
-
CBF-1 (RBP-J kappa) binds to the PTEN promoter and regulates PTEN gene expression.
Whelan JT, Forbes SL, Bertrand FE
Cell Cycle. 2007
PubMed ID: 17245125
-
Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner.
Schouwey K, Delmas V, Larue L, Zimber-Strobl U, Strobl LJ, Radtke F, Beermann F
Dev Dyn. 2007
PubMed ID: 17080428
-
Canonical notch signaling functions as a commitment switch in the epidermal lineage.
Blanpain C, Lowry WE, Pasolli HA, Fuchs E
Genes Dev. 2006
PubMed ID: 17079689
-
Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis.
Zhu X, Zhang J, Tollkuhn J, Ohsawa R, Bresnick EH, Guillemot F, Kageyama R, Rosenfeld MG
Genes Dev. 2006
PubMed ID: 17015435
-
Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway.
Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M
J Biol Chem. 2006
PubMed ID: 16867989
-
Notch1 confers thymocytes a resistance to GC-induced apoptosis through Deltex1 by blocking the recruitment of p300 to the SRG3 promoter.
Jang J, Choi YI, Choi J, Lee KY, Chung H, Jeon SH, Seong RH
Cell Death Differ. 2006
PubMed ID: 16341126
-
Epstein-Barr virus nuclear antigen 2 trans-activates the cellular antiapoptotic bfl-1 gene by a CBF1/RBPJ kappa-dependent pathway.
Pegman PM, Smith SM, D'Souza BN, Loughran ST, Maier S, Kempkes B, Cahill PA, Simmons MJ, Gélinas C, Walls D
J Virol. 2006
PubMed ID: 16873269
-
RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development.
Souilhol C, Cormier S, Tanigaki K, Babinet C, Cohen-Tannoudji M
Mol Cell Biol. 2006
PubMed ID: 16782866
-
The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.
Tanaka S, Tsukada J, Suzuki W, Hayashi K, Tanigaki K, Tsuji M, Inoue H, Honjo T, Kubo M
Immunity. 2006
PubMed ID: 16782026
-
Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1.
Mohan J, Dement-Brown J, Maier S, Ise T, Kempkes B, Tolnay M
Blood. 2006
PubMed ID: 16439682
-
The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy.
Buono KD, Robinson GW, Martin C, Shi S, Stanley P, Tanigaki K, Honjo T, Hennighausen L
Dev Biol. 2006
PubMed ID: 16581056
-
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells.
Moriyama M, Osawa M, Mak SS, Ohtsuka T, Yamamoto N, Han H, Delmas V, Kageyama R, Beermann F, Larue L, Nishikawa S
J Cell Biol. 2006
PubMed ID: 16651378
-
c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes.
Subramanyam D, Krishna S
Virology. 2006
PubMed ID: 16378632
-
The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis.
Shen H, McElhinny AS, Cao Y, Gao P, Liu J, Bronson R, Griffin JD, Wu L
Genes Dev. 2006
PubMed ID: 16510869
-
Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
Nam Y, Sliz P, Song L, Aster JC, Blacklow SC
Cell. 2006
PubMed ID: 16530044
-
Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis.
Dale JK, Malapert P, Chal J, Vilhais-Neto G, Maroto M, Johnson T, Jayasinghe S, Trainor P, Herrmann B, Pourquié O
Dev Cell. 2006
PubMed ID: 16516838
-
PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.
Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ
Mol Cell Biol. 2006
PubMed ID: 16354684
-
Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas.
Yamamoto N, Tanigaki K, Tsuji M, Yabe D, Ito J, Honjo T
J Mol Med. 2006
PubMed ID: 16283144
-
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes.
Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W, Borggrefe T
Mol Cell Biol. 2005
PubMed ID: 16287852
-
Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro.
Morrow D, Scheller A, Birney YA, Sweeney C, Guha S, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA
Am J Physiol Cell Physiol. 2005
PubMed ID: 15987768
-
Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
Barsi JC, Rajendra R, Wu JI, Artzt K
Mech Dev. 2005
PubMed ID: 16061358
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, Kong YY
Development. 2005
PubMed ID: 16000382
-
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.
Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA
Nat Immunol. 2005
PubMed ID: 15991363
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.
van Es JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, Cozijnsen M, Robine S, Winton DJ, Radtke F, Clevers H
Nature. 2005
PubMed ID: 15959515
-
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
Huppert SS, Ilagan MX, De Strooper B, Kopan R
Dev Cell. 2005
PubMed ID: 15866159
-
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
-
RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.
Robert-Moreno A, Espinosa L, de la Pompa JL, Bigas A
Development. 2005
PubMed ID: 15689374
-
The PcG protein HPC2 inhibits RBP-J-mediated transcription by interacting with LIM protein KyoT2.
Qin H, Du D, Zhu Y, Li J, Feng L, Liang Y, Han H
FEBS Lett. 2005
PubMed ID: 15710417
-
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
-
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
-
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
Fryer CJ, White JB, Jones KA
Mol Cell. 2004
PubMed ID: 15546612
-
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.
Yoon K, Nery S, Rutlin ML, Radtke F, Fishell G, Gaiano N
J Neurosci. 2004
PubMed ID: 15509736
-
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.
Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T
Genes Dev. 2004
PubMed ID: 15466160
-
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
-
Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.
Cormier S, Vandormael-Pournin S, Babinet C, Cohen-Tannoudji M
Gene Expr Patterns. 2004
PubMed ID: 15465494
-
Notch4-induced inhibition of endothelial sprouting requires the ankyrin repeats and involves signaling through RBP-Jkappa.
MacKenzie F, Duriez P, Larrivée B, Chang L, Pollet I, Wong F, Yip C, Karsan A
Blood. 2004
PubMed ID: 15187023
-
Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway.
Sweeney C, Morrow D, Birney YA, Coyle S, Hennessy C, Scheller A, Cummins PM, Walls D, Redmond EM, Cahill PA
FASEB J. 2004
PubMed ID: 15247148
-
Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823
-
RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA.
Liang Y, Ganem D
J Virol. 2004
PubMed ID: 15194757
-
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.
Amsen D, Blander JM, Lee GR, Tanigaki K, Honjo T, Flavell RA
Cell. 2004
PubMed ID: 15137944
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Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling.
Tanigaki K, Tsuji M, Yamamoto N, Han H, Tsukada J, Inoue H, Kubo M, Honjo T
Immunity. 2004
PubMed ID: 15142529
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1.
Chu J, Bresnick EH
J Biol Chem. 2004
PubMed ID: 14645224
-
Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways.
MacKenzie F, Duriez P, Wong F, Noseda M, Karsan A
J Biol Chem. 2004
PubMed ID: 14701863
-
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
Paces-Fessy M, Boucher D, Petit E, Paute-Briand S, Blanchet-Tournier MF
Biochem J. 2004
PubMed ID: 14611647
-
The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.
Lim JW, Kim H, Kim KH
J Biol Chem. 2004
PubMed ID: 14570916
-
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
-
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.
Timmerman LA, Grego-Bessa J, Raya A, Bertrán E, Pérez-Pomares JM, Díez J, Aranda S, Palomo S, McCormick F, Izpisúa-Belmonte JC, de la Pompa JL
Genes Dev. 2004
PubMed ID: 14701881
-
Transcriptome analysis of mouse stem cells and early embryos.
Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS
PLoS Biol. 2003
PubMed ID: 14691545
-
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
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Learning and memory deficits in Notch mutant mice.
Costa RM, Honjo T, Silva AJ
Curr Biol. 2003
PubMed ID: 12906797
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Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling.
Liang Y, Ganem D
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12832621
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Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development.
Yun TJ, Bevan MJ
J Immunol. 2003
PubMed ID: 12794108
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Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.
Nam Y, Weng AP, Aster JC, Blacklow SC
J Biol Chem. 2003
PubMed ID: 12644465
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Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos.
Raya A, Kawakami Y, Rodriguez-Esteban C, Buscher D, Koth CM, Itoh T, Morita M, Raya RM, Dubova I, Bessa JG, de la Pompa JL, Belmonte JC
Genes Dev. 2003
PubMed ID: 12730123
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Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis.
Schroeder T, Fraser ST, Ogawa M, Nishikawa S, Oka C, Bornkamm GW, Nishikawa S, Honjo T, Just U
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12655061
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Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.
Yamamoto N, Tanigaki K, Han H, Hiai H, Honjo T
Curr Biol. 2003
PubMed ID: 12593800
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Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.
Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T
Immunity. 2003
PubMed ID: 12594956
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic Acids Res. 2003
PubMed ID: 12520002
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.
Oswald F, Kostezka U, Astrahantseff K, Bourteele S, Dillinger K, Zechner U, Ludwig L, Wilda M, Hameister H, Knöchel W, Liptay S, Schmid RM
EMBO J. 2002
PubMed ID: 12374742
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The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway.
Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D
Genes Dev. 2002
PubMed ID: 12154127
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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
Han H, Tanigaki K, Yamamoto N, Kuroda K, Yoshimoto M, Nakahata T, Ikuta K, Honjo T
Int Immunol. 2002
PubMed ID: 12039915
-
Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.
Jeffries S, Robbins DJ, Capobianco AJ
Mol Cell Biol. 2002
PubMed ID: 11997524
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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.
Tanigaki K, Han H, Yamamoto N, Tashiro K, Ikegawa M, Kuroda K, Suzuki A, Nakano T, Honjo T
Nat Immunol. 2002
PubMed ID: 11967543
-
Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.
Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D
Genes Dev. 2002
PubMed ID: 11937492
-
HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.
Dintilhac A, Bernués J
J Biol Chem. 2002
PubMed ID: 11748221
-
HERP1 is a cell type-specific primary target of Notch.
Iso T, Chung G, Hamamori Y, Kedes L
J Biol Chem. 2002
PubMed ID: 11741889
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Notch signaling inhibits PC12 cell neurite outgrowth via RBP-J-dependent and -independent mechanisms.
Levy OA, Lah JJ, Levey AI
Dev Neurosci. 2002
PubMed ID: 12145413
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p300 acts as a transcriptional coactivator for mammalian Notch-1.
Oswald F, Täuber B, Dobner T, Bourteele S, Kostezka U, Adler G, Liptay S, Schmid RM
Mol Cell Biol. 2001
PubMed ID: 11604511
-
Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.
Saxena MT, Schroeter EH, Mumm JS, Kopan R
J Biol Chem. 2001
PubMed ID: 11518718
-
Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
PubMed ID: 11544199
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Mutational analysis of the J recombination signal sequence binding protein (RBP-J)/Epstein-Barr virus nuclear antigen 2 (EBNA2) and RBP-J/Notch interaction.
Fuchs KP, Bommer G, Dumont E, Christoph B, Vidal M, Kremmer E, Kempkes B
Eur J Biochem. 2001
PubMed ID: 11532000
-
Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex.
Zhou S, Hayward SD
Mol Cell Biol. 2001
PubMed ID: 11509665
-
The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity.
Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U
Mech Dev. 2001
PubMed ID: 11404076
-
p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos.
Obata J, Yano M, Mimura H, Goto T, Nakayama R, Mibu Y, Oka C, Kawaichi M
Genes Cells. 2001
PubMed ID: 11318877
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5.
Kurooka H, Honjo T
J Biol Chem. 2000
PubMed ID: 10747963
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Functional interactions between an atypical NF-kappaB site from the rat CYP2B1 promoter and the transcriptional repressor RBP-Jkappa/CBF1.
Lee SH, Wang X, DeJong J
Nucleic Acids Res. 2000
PubMed ID: 10773077
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SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD
Mol Cell Biol. 2000
PubMed ID: 10713164
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Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus.
Smith PR, de Jesus O, Turner D, Hollyoake M, Karstegl CE, Griffin BE, Karran L, Wang Y, Hayward SD, Farrell PJ
J Virol. 2000
PubMed ID: 10708423
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A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD
J Virol. 2000
PubMed ID: 10644367
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Assignment of the mouse Rbpsuh gene to chromosome 5 and one processed pseudogene Rbpsuh-rs3 to chromosome 6.
Klein BS, Himmelbauer H, Zechner U, Riemann M, Liptay S, Hameister H, Schmid RM
Cytogenet Cell Genet. 2000
PubMed ID: 10828593
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Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression.
Kao HY, Downes M, Ordentlich P, Evans RM
Genes Dev. 2000
PubMed ID: 10640276
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Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.
Callahan J, Aster J, Sklar J, Kieff E, Robertson ES
Leukemia. 2000
PubMed ID: 10637481
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Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ
Int J Cancer. 1999
PubMed ID: 10508479
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Notch signalling controls pancreatic cell differentiation.
Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H
Nature. 1999
PubMed ID: 10476967
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Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.
Barrantes IB, Elia AJ, Wünsch K, Hrabe de Angelis MH, Mak TW, Rossant J, Conlon RA, Gossler A, de la Pompa JL
Curr Biol. 1999
PubMed ID: 10330372
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CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
Hsieh JJ, Zhou S, Chen L, Young DB, Hayward SD
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9874765
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region.
Kurooka H, Kuroda K, Honjo T
Nucleic Acids Res. 1998
PubMed ID: 9826771
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Genetic elements regulating HES-1 induction in Wnt-1-transformed PC12 cells.
Issack PS, Ziff EB
Cell Growth Differ. 1998
PubMed ID: 9790494
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A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.
Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T
Genes Dev. 1998
PubMed ID: 9694793
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The renal TGF-beta system in the db/db mouse model of diabetic nephropathy.
Cohen MP, Sharma K, Guo J, Eltayeb BO, Ziyadeh FN
Exp Nephrol. 1998
PubMed ID: 9639038
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LIM protein KyoT2 negatively regulates transcription by association with the RBP-J DNA-binding protein.
Taniguchi Y, Furukawa T, Tun T, Han H, Honjo T
Mol Cell Biol. 1998
PubMed ID: 9418910
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Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization.
Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK
Jpn J Hum Genet. 1997
PubMed ID: 9290259
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RBP-L, a transcription factor related to RBP-Jkappa.
Minoguchi S, Taniguchi Y, Kato H, Okazaki T, Strobl LJ, Zimber-Strobl U, Bornkamm GW, Honjo T
Mol Cell Biol. 1997
PubMed ID: 9111338
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Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription.
Aster JC, Robertson ES, Hasserjian RP, Turner JR, Kieff E, Sklar J
J Biol Chem. 1997
PubMed ID: 9111040
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Conservation of the Notch signalling pathway in mammalian neurogenesis.
de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, Conlon RA
Development. 1997
PubMed ID: 9102301
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Epstein-Barr virus immortalization: Notch2 interacts with CBF1 and blocks differentiation.
Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD
J Virol. 1997
PubMed ID: 9032325
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A pancreatic cancer-specific expression profile.
Gress TM, Müller-Pillasch F, Geng M, Zimmerhackl F, Zehetner G, Friess H, Büchler M, Adler G, Lehrach H
Oncogene. 1996
PubMed ID: 8895530
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a discrete domain of Jkappa.
Zhao B, Marshall DR, Sample CE
J Virol. 1996
PubMed ID: 8676443
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The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa).
Robertson ES, Lin J, Kieff E
J Virol. 1996
PubMed ID: 8627785
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Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).
Tamura K, Taniguchi Y, Minoguchi S, Sakai T, Tun T, Furukawa T, Honjo T
Curr Biol. 1995
PubMed ID: 8749394
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Disruption of the mouse RBP-J kappa gene results in early embryonic death.
Oka C, Nakano T, Wakeham A, de la Pompa JL, Mori C, Sakai T, Okazaki S, Kawaichi M, Shiota K, Mak TW, Honjo T
Development. 1995
PubMed ID: 7588063
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Signalling downstream of activated mammalian Notch.
Jarriault S, Brou C, Logeat F, Schroeter EH, Kopan R, Israel A
Nature. 1995
PubMed ID: 7566092
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The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.
Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E
Mol Cell Biol. 1995
PubMed ID: 7651391
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V(D)J recombination of immunoglobulin genes.
Oka C, Kawaichi M
Adv Biophys. 1995
PubMed ID: 7625272
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Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.
Henkel T, Ling PD, Hayward SD, Peterson MG
Science. 1994
PubMed ID: 8016657
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Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.
Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T
Genomics. 1993
PubMed ID: 8406481
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Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
Kawaichi M, Oka C, Shibayama S, Koromilas AE, Matsunami N, Hamaguchi Y, Honjo T
J Biol Chem. 1992
PubMed ID: 1740450
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Cloning and characterization of a protein binding to the J kappa recombination signal sequence of immunoglobulin genes.
Hamaguchi Y, Mastunami N, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, Kawaichi M, Honjo T
Adv Exp Med Biol. 1991
PubMed ID: 1950768
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A protein binding to the J kappa recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif.
Matsunami N, Hamaguchi Y, Yamamoto Y, Kuze K, Kangawa K, Matsuo H, Kawaichi M, Honjo T
Nature. 1989
PubMed ID: 2556644
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The human kappa deleting element and the mouse recombining segment share DNA sequence homology.
Siminovitch KA, Moore MW, Durdik J, Selsing E
Nucleic Acids Res. 1987
PubMed ID: 3104881
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