APP

Summary Top Help

Gene Description:

amyloid beta (A4) precursor protein

Synonyms:

Ag, PN-II, E030013M08Rik, AD1, Cvap, Abpp, Adap, APP, ABETA, App, CTFgamma, APPI, ABPP, betaApp, CVAP, PN2, AAA, Abeta

Orthologs:

Human APP (protein-coding), Mouse App (protein-coding), Rat App (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Iddm17	Rat	chr11:19445919..87759784	68.31	594

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr21:27252861..27543446 (290.58 kb) View in Genome Browser

(Mouse) NCBIM37 - chr16:84954681..85173952 (219.27 kb) View in Genome Browser

(Rat) RGSC3.4 - chr11:24457766..24693964 (236.20 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for APP:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for APP:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 3

Reactome: 13

NCI-Nature Pathway Interaction Database: 3

Gene Ontology: 74

Publications from PubMed Top Help

Type 1 Diabetes Publications: 17

Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide.
Rezaei-Ghaleh N, Andreetto E, Yan LM, Kapurniotu A, Zweckstetter M
PLoS One. 2011
PubMed ID: 21633500
The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes.
Khemtémourian L, Engel MF, Kruijtzer JA, Höppener JW, Liskamp RM, Killian JA
Eur Biophys J. 2010
PubMed ID: 20052582
Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice.
Jolivalt CG, Hurford R, Lee CA, Dumaop W, Rockenstein E, Masliah E
Exp Neurol. 2010
PubMed ID: 19931251
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Gaspar RC, Villarreal SA, Bowles N, Hepler RW, Joyce JG, Shughrue PJ
Exp Neurol. 2010
PubMed ID: 19744481
Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction.
Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Götz J
Proteomics. 2010
PubMed ID: 20186753
Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.
Apostolidou M, Jayasinghe SA, Langen R
J Biol Chem. 2008
PubMed ID: 18442979
Beta-amyloid peptides 1-40betaA and 25-35betaA suppress human amylin-mediated death of RINm5F islet beta-cells with distinct actions on fibril formation.
Bai JZ
Cell Biol Int. 2008
PubMed ID: 18291688
p35/Cyclin-dependent kinase 5 is required for protection against beta-amyloid-induced cell death but not tau phosphorylation by ceramide.
Seyb KI, Ansar S, Li G, Bean J, Michaelis ML, Dobrowsky RT
J Mol Neurosci. 2007
PubMed ID: 17416967
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
Shen Y, Joachimiak A, Rosner MR, Tang WJ
Nature. 2006
PubMed ID: 17051221
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers.
Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG
J Biol Chem. 2005
PubMed ID: 15722360
Nucleation-dependent polymerization is an essential component of amyloid-mediated neuronal cell death.
Wogulis M, Wright S, Cunningham D, Chilcote T, Powell K, Rydel RE
J Neurosci. 2005
PubMed ID: 15689542
Intracellularly generated amyloid-beta peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells.
Esposito L, Gan L, Yu GQ, Essrich C, Mucke L
J Neurochem. 2004
PubMed ID: 15584903
Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.
Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, Seino S
DNA Res. 2004
PubMed ID: 15747579
Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA
Development. 2004
PubMed ID: 14660441
Localization of a fibrillar amyloid beta-protein binding domain on its precursor.
Van Nostrand WE, Melchor JP, Keane DM, Saporito-Irwin SM, Romanov G, Davis J, Xu F
J Biol Chem. 2002
PubMed ID: 12107175
c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK.
Matsuda S, Yasukawa T, Homma Y, Ito Y, Niikura T, Hiraki T, Hirai S, Ohno S, Kita Y, Kawasumi M, Kouyama K, Yamamoto T, Kyriakis JM, Nishimoto I
J Neurosci. 2001
PubMed ID: 11517249
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, Chishti MA, Horne P, Heslin D, French J, Mount HT, Nixon RA, Mercken M, Bergeron C, Fraser PE, St George-Hyslop P, Westaway D
Nature. 2000
PubMed ID: 11140685

Publications: 1950

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death.
Soura V, Stewart-Parker M, Williams TL, Ratnayaka A, Atherton J, Gorringe K, Tuffin J, Darwent E, Rambaran R, Klein W, Lacor P, Staras K, Thorpe J, Serpell LC
Biochem J. 2012
PubMed ID: 21955321
Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohort.
Schoonenboom NS, Reesink FE, Verwey NA, Kester MI, Teunissen CE, van de Ven PM, Pijnenburg YA, Blankenstein MA, Rozemuller AJ, Scheltens P, van der Flier WM
Neurology. 2012
PubMed ID: 22170879
Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia.
Buchhave P, Minthon L, Zetterberg H, Wallin AK, Blennow K, Hansson O
Arch Gen Psychiatry. 2012
PubMed ID: 22213792
Butyrylcholinesterase is associated with β-amyloid plaques in the transgenic APPSWE/PSEN1dE9 mouse model of Alzheimer disease.
Darvesh S, Cash MK, Reid GA, Martin E, Mitnitski A, Geula C
J Neuropathol Exp Neurol. 2012
PubMed ID: 22157615
Estrogen receptors and type 1 metabotropic glutamate receptors are interdependent in protecting cortical neurons against β-amyloid toxicity.
Spampinato SF, Molinaro G, Merlo S, Iacovelli L, Caraci F, Battaglia G, Nicoletti F, Bruno V, Sortino MA
Mol Pharmacol. 2012
PubMed ID: 21984253
c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model.
Sclip A, Antoniou X, Colombo A, Camici GG, Pozzi L, Cardinetti D, Feligioni M, Veglianese P, Bahlmann FH, Cervo L, Balducci C, Costa C, Tozzi A, Calabresi P, Forloni G, Borsello T
J Biol Chem. 2011
PubMed ID: 22033930
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, Olofsson A, DeJager PL, Tanzi RE, Caldwell KA, Caldwell GA, Lindquist S
Science. 2011
PubMed ID: 22033521
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
Disordered binding of small molecules to Aβ(12-28).
Convertino M, Vitalis A, Caflisch A
J Biol Chem. 2011
PubMed ID: 21969380
Evidence for ordering of Alzheimer disease biomarkers.
Jack CR, Vemuri P, Wiste HJ, Weigand SD, Aisen PS, Trojanowski JQ, Shaw LM, Bernstein MA, Petersen RC, Weiner MW, Knopman DS, Alzheimer's Disease Neuroimaging Initiative
Arch Neurol. 2011
PubMed ID: 21825215
Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation.
Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN
Neurobiol Dis. 2011
PubMed ID: 21798347
NSAID-based γ-secretase modulators do not bind to the amyloid-β polypeptide.
Barrett PJ, Sanders CR, Kaufman SA, Michelsen K, Jordan JB
Biochemistry. 2011
PubMed ID: 21995415
ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, Griffith LG, Lauffenburger DA, Petrovich R, Bartsch JW
J Biol Chem. 2011
PubMed ID: 21956108
Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia.
Neniskyte U, Neher JJ, Brown GC
J Biol Chem. 2011
PubMed ID: 21903584
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.
Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH
J Biol Chem. 2011
PubMed ID: 21868380
Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane regio
Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, Golde TE
J Biol Chem. 2011
PubMed ID: 21868378
Distinguishing amyloid fibril structures in Alzheimer's disease (AD) by two-dimensional ultraviolet (2DUV) spectroscopy.
Lam AR, Jiang J, Mukamel S
Biochemistry. 2011
PubMed ID: 21961527
Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.
Jawhar S, Wirths O, Bayer TA
J Biol Chem. 2011
PubMed ID: 21965666
Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line.
Sung HY, Choi EN, Ahn Jo S, Oh S, Ahn JH
Biochem Biophys Res Commun. 2011
PubMed ID: 22001921
Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins.
Bate C, Williams A
J Biol Chem. 2011
PubMed ID: 21900234
Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ
J Neurosci. 2011
PubMed ID: 22049429
MHC-independent genetic factors control the magnitude of CD4+ T cell responses to amyloid-β peptide in mice through regulatory T cell-mediated inhibition.
Toly-Ndour C, Lui G, Nunes MM, Bruley-Rosset M, Aucouturier P, Dorothée G
J Immunol. 2011
PubMed ID: 21949026
Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.
Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ
J Neurochem. 2011
PubMed ID: 21883219
Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes.
Pihlaja R, Koistinaho J, Kauppinen R, Sandholm J, Tanila H, Koistinaho M
Glia. 2011
PubMed ID: 21826742
Comparison of mRNA expression patterns of class B scavenger receptors in BV2 microglia upon exposure to amyloidogenic fragments of beta-amyloid and prion proteins.
Kouadir M, Yang L, Tu J, Yin X, Zhou X, Zhao D
DNA Cell Biol. 2011
PubMed ID: 21631281
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF
Cell. 2011
PubMed ID: 22036569
Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease.
Ngo S, Guo Z
Biochem Biophys Res Commun. 2011
PubMed ID: 21986527
BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).
Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J
J Biol Chem. 2011
PubMed ID: 21873424
Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.
Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS
Biochemistry. 2011
PubMed ID: 21919498
A new structural model of Aβ40 fibrils.
Bertini I, Gonnelli L, Luchinat C, Mao J, Nesi A
J Am Chem Soc. 2011
PubMed ID: 21882806
Molecular basis for amyloid-beta polymorphism.
Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21949245
A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36.
Wilkinson K, Boyd JD, Glicksman M, Moore KJ, El Khoury J
J Biol Chem. 2011
PubMed ID: 21835916
Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains.
Lasagna-Reeves CA, Kayed R
FEBS Lett. 2011
PubMed ID: 21872592
Amyloid-β associated volume loss occurs only in the presence of phospho-tau.
Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM, Alzheimer’s Disease Neuroimaging Initiative
Ann Neurol. 2011
PubMed ID: 22002658
Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice.
Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J
J Clin Invest. 2011
PubMed ID: 21881209
Substituted tryptophans at amyloid-β(1-40) residues 19 and 20 experience different environments after fibril formation.
McDonough RT, Paranjape G, Gallazzi F, Nichols MR
Arch Biochem Biophys. 2011
PubMed ID: 21843498
The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M
J Neurochem. 2011
PubMed ID: 21812781
Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.
Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G, Schaffner W
Biol Chem. 2011
PubMed ID: 21801085
Polymorphic triple beta-sheet structures contribute to amide hydrogen/deuterium (H/D) exchange protection in the Alzheimer amyloid beta42 peptide.
Ma B, Nussinov R
J Biol Chem. 2011
PubMed ID: 21832091
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
Oláh J, Vincze O, Virók D, Simon D, Bozsó Z, Tõkési N, Horváth I, Hlavanda E, Kovács J, Magyar A, Szũcs M, Orosz F, Penke B, Ovádi J
J Biol Chem. 2011
PubMed ID: 21832049
Role of key aromatic residues in the ligand-binding domain of alpha7 nicotinic receptors in the agonist action of beta-amyloid.
Tong M, Arora K, White MM, Nichols RA
J Biol Chem. 2011
PubMed ID: 21828053
Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.
Schieb H, Kratzin H, Jahn O, Möbius W, Rabe S, Staufenbiel M, Wiltfang J, Klafki HW
J Biol Chem. 2011
PubMed ID: 21795681
Respiratory and sniffing behaviors throughout adulthood and aging in mice.
Wesson DW, Varga-Wesson AG, Borkowski AH, Wilson DA
Behav Brain Res. 2011
PubMed ID: 21524667
In vivo olfactory model of APP-induced neurodegeneration reveals a reversible cell-autonomous function.
Cheng N, Cai H, Belluscio L
J Neurosci. 2011
PubMed ID: 21957232
The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?
Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC
Biochemistry. 2011
PubMed ID: 21838267
Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.
Griffiths HH, Whitehouse IJ, Baybutt H, Brown D, Kellett KA, Jackson CD, Turner AJ, Piccardo P, Manson JC, Hooper NM
J Biol Chem. 2011
PubMed ID: 21795680
Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.
Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z
Behav Brain Res. 2011
PubMed ID: 21513747
Iron(II) binding to amyloid-β, the Alzheimer's peptide.
Bousejra-ElGarah F, Bijani C, Coppel Y, Faller P, Hureau C
Inorg Chem. 2011
PubMed ID: 21800824
Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.
Walker JM, Fowler SW, Miller DK, Sun AY, Weisman GA, Wood WG, Sun GY, Simonyi A, Schachtman TR
Behav Brain Res. 2011
PubMed ID: 21443906
The role of factor XIa (FXIa) catalytic domain exosite residues in substrate catalysis and inhibition by the Kunitz protease inhibitor domain of protease nexin 2.
Su YC, Miller TN, Navaneetham D, Schoonmaker RT, Sinha D, Walsh PN
J Biol Chem. 2011
PubMed ID: 21778227
DC2 and keratinocyte-associated protein 2 (KCP2), subunits of the oligosaccharyltransferase complex, are regulators of the gamma-secretase-directed processing of amyloid precursor protein (APP).
Wilson CM, Magnaudeix A, Yardin C, Terro F
J Biol Chem. 2011
PubMed ID: 21768116
Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
Pamrén A, Wanngren J, Tjernberg LO, Winblad B, Bhat R, Näslund J, Karlström H
J Biol Chem. 2011
PubMed ID: 21768095
Magnetic resonance spectroscopy, β-amyloid load, and cognition in a population-based sample of cognitively normal older adults.
Kantarci K, Lowe V, Przybelski SA, Senjem ML, Weigand SD, Ivnik RJ, Roberts R, Geda YE, Boeve BF, Knopman DS, Petersen RC, Jack CR
Neurology. 2011
PubMed ID: 21865577
Homogeneous and heterogeneous tertiary structure ensembles of amyloid-β peptides.
Ball KA, Phillips AH, Nerenberg PS, Fawzi NL, Wemmer DE, Head-Gordon T
Biochemistry. 2011
PubMed ID: 21797254
Cerebrospinal fluid biomarkers, education, brain volume, and future cognition.
Roe CM, Fagan AM, Grant EA, Marcus DS, Benzinger TL, Mintun MA, Holtzman DM, Morris JC
Arch Neurol. 2011
PubMed ID: 21911695
The effects of amyloid-β42 oligomer on the proliferation and activation of astrocytes in vitro.
Hou L, Liu Y, Wang X, Ma H, He J, Zhang Y, Yu C, Guan W, Ma Y
In Vitro Cell Dev Biol Anim. 2011
PubMed ID: 21858610
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Jeon S, Bose S, Hur J, Jun K, Kim YK, Cho KS, Koo BS
J Ethnopharmacol. 2011
PubMed ID: 21762767
Occlusal disharmony increases amyloid-β in the rat hippocampus.
Ekuni D, Tomofuji T, Irie K, Azuma T, Endo Y, Kasuyama K, Morita M
Neuromolecular Med. 2011
PubMed ID: 21751079
Comparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology.
Fagan AM, Shaw LM, Xiong C, Vanderstichele H, Mintun MA, Trojanowski JQ, Coart E, Morris JC, Holtzman DM
Arch Neurol. 2011
PubMed ID: 21555603
Amyloid precursor protein gene (APP) variation in late-onset Alzheimer's disease.
Miar A, Alvarez V, Corao AI, Díaz M, Alonso B, Martínez C, Calatayud MT, Menéndez M, Morís G, Coto E
J Mol Neurosci. 2011
PubMed ID: 21424791
Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy.
Carrano A, Hoozemans JJ, van der Vies SM, Rozemuller AJ, van Horssen J, de Vries HE
Antioxid Redox Signal. 2011
PubMed ID: 21294650
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1.
Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21825135
Wnt/β-catenin signal pathway stabilizes APP intracellular domain (AICD) and promotes its transcriptional activity.
Zhou F, Gong K, van Laar T, Gong Y, Zhang L
Biochem Biophys Res Commun. 2011
PubMed ID: 21798242
APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.
Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L
J Neurosci. 2011
PubMed ID: 21849536
Amyloid-dependent and amyloid-independent stages of Alzheimer disease.
Hyman BT
Arch Neurol. 2011
PubMed ID: 21482918
A partially folded structure of amyloid-beta(1-40) in an aqueous environment.
Vivekanandan S, Brender JR, Lee SY, Ramamoorthy A
Biochem Biophys Res Commun. 2011
PubMed ID: 21726530
Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides.
Pedersen JT, Østergaard J, Rozlosnik N, Gammelgaard B, Heegaard NH
J Biol Chem. 2011
PubMed ID: 21642429
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G
J Biol Chem. 2011
PubMed ID: 21642424
Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid.
Halim A, Brinkmalm G, Rüetschi U, Westman-Brinkmalm A, Portelius E, Zetterberg H, Blennow K, Larson G, Nilsson J
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21712440
Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.
Mulvihill MM, Guttman M, Komives EA
Biochemistry. 2011
PubMed ID: 21650223
APP/SOD1 overexpressing mice present reduced neuropathic pain sensitivity.
Kotulska K, Larysz-Brysz M, LePecheur M, Marcol W, Olakowska E, Lewin-Kowalik J, London J
Brain Res Bull. 2011
PubMed ID: 21605634
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
Bedrosian TA, Herring KL, Weil ZM, Nelson RJ
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21709248
Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.
Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G
J Mol Biol. 2011
PubMed ID: 21621545
Monte Carlo study of the formation and conformational properties of dimers of Aβ42 variants.
Mitternacht S, Staneva I, Härd T, Irbäck A
J Mol Biol. 2011
PubMed ID: 21616081
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M
J Biol Chem. 2011
PubMed ID: 21606494
Face-name associative memory performance is related to amyloid burden in normal elderly.
Rentz DM, Amariglio RE, Becker JA, Frey M, Olson LE, Frishe K, Carmasin J, Maye JE, Johnson KA, Sperling RA
Neuropsychologia. 2011
PubMed ID: 21689670
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Manczak M, Calkins MJ, Reddy PH
Hum Mol Genet. 2011
PubMed ID: 21459773
Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier.
Bachmeier CJ, Beaulieu-Abdelahad D, Mullan MJ, Paris D
Microcirculation. 2011
PubMed ID: 21418385
Liver X receptor activation restores memory in aged AD mice without reducing amyloid.
Vanmierlo T, Rutten K, Dederen J, Bloks VW, van Vark-van der Zee LC, Kuipers F, Kiliaan A, Blokland A, Sijbrands EJ, Steinbusch H, Prickaerts J, Lütjohann D, Mulder M
Neurobiol Aging. 2011
PubMed ID: 19674815
Hypoxia induces beta-amyloid in association with death of RGC-5 cells in culture.
Li J, Dong Z, Liu B, Zhuo Y, Sun X, Yang Z, Ge J, Tan Z
Biochem Biophys Res Commun. 2011
PubMed ID: 21640074
The E2 domains of APP and APLP1 share a conserved mode of dimerization.
Lee S, Xue Y, Hu J, Wang Y, Liu X, Demeler B, Ha Y
Biochemistry. 2011
PubMed ID: 21574595
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes.
Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T
J Immunol. 2011
PubMed ID: 21551363
Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation.
Reifert J, Hartung-Cranston D, Feinstein SC
J Biol Chem. 2011
PubMed ID: 21482827
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events.
Belakavadi M, Dell J, Grover GJ, Fondell JD
Mol Cell Endocrinol. 2011
PubMed ID: 21458529
Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.
Nelson LD, Siddarth P, Kepe V, Scheibel KE, Huang SC, Barrio JR, Small GW
Arch Neurol. 2011
PubMed ID: 21670401
Regulation of Notch1 signaling by the APP intracellular domain facilitates degradation of the Notch1 intracellular domain and RBP-Jk.
Kim MY, Mo JS, Ann EJ, Yoon JH, Jung J, Choi YH, Kim SM, Kim HY, Ahn JS, Kim H, Kim K, Hoe HS, Park HS
J Cell Sci. 2011
PubMed ID: 21558417
Neuronal activity regulates the regional vulnerability to amyloid-β deposition.
Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM
Nat Neurosci. 2011
PubMed ID: 21532579
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J
EMBO J. 2011
PubMed ID: 21527912
The mechanism for heme to prevent Aβ(1-40) aggregation and its cytotoxicity.
Bao Q, Luo Y, Li W, Sun X, Zhu C, Li P, Huang ZX, Tan X
J Biol Inorg Chem. 2011
PubMed ID: 21523435
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.
Weyer SW, Klevanski M, Delekate A, Voikar V, Aydin D, Hick M, Filippov M, Drost N, Schaller KL, Saar M, Vogt MA, Gass P, Samanta A, Jäschke A, Korte M, Wolfer DP, Caldwell JH, Müller UC
EMBO J. 2011
PubMed ID: 21522131
Outcome-specific satiety reveals a deficit in context-outcome, but not stimulus- or action-outcome, associations in aged Tg2576 mice.
Lelos MJ, Thomas RS, Kidd EJ, Good MA
Behav Neurosci. 2011
PubMed ID: 21480689
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M
Mol Cell Biol. 2011
PubMed ID: 21464208
Recent progress in understanding Alzheimer's β-amyloid structures.
Fändrich M, Schmidt M, Grigorieff N
Trends Biochem Sci. 2011
PubMed ID: 21411326
Parkin mediates beclin-dependent autophagic clearance of defective mitochondria and ubiquitinated Abeta in AD models.
Khandelwal PJ, Herman AM, Hoe HS, Rebeck GW, Moussa CE
Hum Mol Genet. 2011
PubMed ID: 21378096
Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity.
Bolognin S, Messori L, Drago D, Gabbiani C, Cendron L, Zatta P
Int J Biochem Cell Biol. 2011
PubMed ID: 21376832
Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein.
Linde CI, Baryshnikov SG, Mazzocco-Spezzia A, Golovina VA
Am J Physiol Cell Physiol. 2011
PubMed ID: 21368296
In vitro Pb exposure disturbs the balance between Aβ production and elimination: the role of AβPP and neprilysin.
Huang H, Bihaqi SW, Cui L, Zawia NH
Neurotoxicology. 2011
PubMed ID: 21315759
Loss of amyloid precursor protein in a mouse model of Niemann-Pick type C disease exacerbates its phenotype and disrupts tau homeostasis.
Nunes A, Pressey SN, Cooper JD, Soriano S
Neurobiol Dis. 2011
PubMed ID: 21303697
Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity.
Shim S, Lee W, Chung H, Jung YK
Cell Mol Life Sci. 2011
PubMed ID: 20972601
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse m
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J
J Biol Chem. 2011
PubMed ID: 21460223
Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM
J Neurosci. 2011
PubMed ID: 21613482
Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.
Wang H, Barreyro L, Provasi D, Djemil I, Torres-Arancivia C, Filizola M, Ubarretxena-Belandia I
J Mol Biol. 2011
PubMed ID: 21440556
Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein.
Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ
J Neurosci. 2011
PubMed ID: 21593310
Mutations that replace aromatic side chains promote aggregation of the Alzheimer's Aβ peptide.
Armstrong AH, Chen J, McKoy AF, Hecht MH
Biochemistry. 2011
PubMed ID: 21513285
The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
Ovchinnikova OY, Finder VH, Vodopivec I, Nitsch RM, Glockshuber R
J Mol Biol. 2011
PubMed ID: 21402079
Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.
Moghekar A, Rao S, Li M, Ruben D, Mammen A, Tang X, O'Brien RJ
J Biol Chem. 2011
PubMed ID: 21454701
APPswe/Aβ regulation of osteoclast activation and RAGE expression in an age-dependent manner.
Cui S, Xiong F, Hong Y, Jung JU, Li XS, Liu JZ, Yan R, Mei L, Feng X, Xiong WC
J Bone Miner Res. 2011
PubMed ID: 21542009
Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation.
Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B
EMBO Mol Med. 2011
PubMed ID: 21500352
SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis.
Esteve P, Sandonìs A, Cardozo M, Malapeira J, Ibañez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P
Nat Neurosci. 2011
PubMed ID: 21478884
Apoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer's disease - a basic model of apoptosis?
Thinnes FP
Wien Med Wochenschr. 2011
PubMed ID: 21442216
Mapping ApoE/Aβ binding regions to guide inhibitor discovery.
Liu Q, Wu WH, Fang CL, Li RW, Liu P, Lei P, Hu J, Sun X, Zheng YZ, Zhao YF, Li YM
Mol Biosyst. 2011
PubMed ID: 21409287
Computational prediction and analysis of the DR6-NAPP interaction.
Ponomarev SY, Audie J
Proteins. 2011
PubMed ID: 21337622
Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
Shafaati M, Marutle A, Pettersson H, Lövgren-Sandblom A, Olin M, Pikuleva I, Winblad B, Nordberg A, Björkhem I
J Lipid Res. 2011
PubMed ID: 21335619
Attenuated atherogenesis in apolipoprotein E-deficient mice lacking amyloid precursor protein.
Van De Parre TJ, Guns PJ, Fransen P, Martinet W, Bult H, Herman AG, De Meyer GR
Atherosclerosis. 2011
PubMed ID: 21316678
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Cerf E, Gustot A, Goormaghtigh E, Ruysschaert JM, Raussens V
FASEB J. 2011
PubMed ID: 21266538
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.
Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP
J Biol Chem. 2011
PubMed ID: 21393248
Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium.
Nag S, Sarkar B, Bandyopadhyay A, Sahoo B, Sreenivasan VK, Kombrabail M, Muralidharan C, Maiti S
J Biol Chem. 2011
PubMed ID: 21349839
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.
Grimm MO, Kuchenbecker J, Grösgen S, Burg VK, Hundsdörfer B, Rothhaar TL, Friess P, de Wilde MC, Broersen LM, Penke B, Péter M, Vígh L, Grimm HS, Hartmann T
J Biol Chem. 2011
PubMed ID: 21324907
Amyloid β-induced erythrocytic damage and its attenuation by carotenoids.
Nakagawa K, Kiko T, Miyazawa T, Sookwong P, Tsuduki T, Satoh A, Miyazawa T
FEBS Lett. 2011
PubMed ID: 21459092
Alterations of cyclin dependent kinase 5 expression and phosphorylation in amyloid precursor protein (APP)-transfected PC12 cells.
Czapski GA, Gąssowska M, Songin M, Radecka UD, Strosznajder JB
FEBS Lett. 2011
PubMed ID: 21457712
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
Trazzi S, Mitrugno VM, Valli E, Fuchs C, Rizzi S, Guidi S, Perini G, Bartesaghi R, Ciani E
Hum Mol Genet. 2011
PubMed ID: 21266456
P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes.
Tran MD
Neurosci Lett. 2011
PubMed ID: 21300137
Platelet amyloid precursor protein isoform expression in Alzheimer's disease: evidence for peripheral marker.
Vignini A, Sartini D, Morganti S, Nanetti L, Luzzi S, Provinciali L, Mazzanti L, Emanuelli M
Int J Immunopathol Pharmacol. 2011
PubMed ID: 21658330
The increased density of p38 mitogen-activated protein kinase-immunoreactive microglia in the sensorimotor cortex of aged TgCRND8 mice is associated predominantly with smaller dense-core amyloid plaques.
Chlan-Fourney J, Zhao T, Walz W, Mousseau DD
Eur J Neurosci. 2011
PubMed ID: 21323766
Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.
Matsumura S, Shinoda K, Yamada M, Yokojima S, Inoue M, Ohnishi T, Shimada T, Kikuchi K, Masui D, Hashimoto S, Sato M, Ito A, Akioka M, Takagi S, Nakamura Y, Nemoto K, Hasegawa Y, Takamoto H, Inoue H, Nakamura S, Nabeshima Y, Teplow DB, Kinjo M, Hoshi M
J Biol Chem. 2011
PubMed ID: 21292768
Activity-induced dendrite and dendritic spine development in human amyloid precursor protein transgenic mice.
Alpár A, Ueberham U, Lendvai D, Naumann N, Rohn S, Gáti G, Arendt T, Gärtner U
Int J Dev Neurosci. 2011
PubMed ID: 21277971
The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency.
Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A
Biochim Biophys Acta. 2011
PubMed ID: 21262195
Low-n oligomers as therapeutic targets of Alzheimer's disease.
Ono K, Yamada M
J Neurochem. 2011
PubMed ID: 21244429
Solution NMR studies of Aβ monomer dynamics.
Wang C
Protein Pept Lett. 2011
PubMed ID: 21222639
Folding stability of amyloid-beta 40 monomer is an important determinant of the nucleation kinetics in fibrillization.
Ni CL, Shi HP, Yu HM, Chang YC, Chen YR
FASEB J. 2011
PubMed ID: 21209058
The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.
Ohkawara T, Nagase H, Koh CS, Nakayama K
Gene. 2011
PubMed ID: 21145952
Amyloid β-induced death in neurons involves glial and neuronal hemichannels.
Orellana JA, Shoji KF, Abudara V, Ezan P, Amigou E, Sáez PJ, Jiang JX, Naus CC, Sáez JC, Giaume C
J Neurosci. 2011
PubMed ID: 21451035
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, Suhara T, Higuchi M
J Neurosci. 2011
PubMed ID: 21430171
A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.
Barbagallo AP, Wang Z, Zheng H, D'Adamio L
J Biol Chem. 2011
PubMed ID: 21266574
Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
Caccamo A, Maldonado MA, Majumder S, Medina DX, Holbein W, Magrí A, Oddo S
J Biol Chem. 2011
PubMed ID: 21266573
Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation.
Chen WT, Liao YH, Yu HM, Cheng IH, Chen YR
J Biol Chem. 2011
PubMed ID: 21216965
Copper promotes the trafficking of the amyloid precursor protein.
Acevedo KM, Hung YH, Dalziel AH, Li QX, Laughton K, Wikhe K, Rembach A, Roberts B, Masters CL, Bush AI, Camakaris J
J Biol Chem. 2011
PubMed ID: 21177866
Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.
Jan A, Adolfsson O, Allaman I, Buccarello AL, Magistretti PJ, Pfeifer A, Muhs A, Lashuel HA
J Biol Chem. 2011
PubMed ID: 21156804
Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).
Romberg C, Mattson MP, Mughal MR, Bussey TJ, Saksida LM
J Neurosci. 2011
PubMed ID: 21368062
Amyloid β (Aβ) and phospho-tau (p-tau) as diagnostic biomarkers in Alzheimer's disease.
Prvulovic D, Hampel H
Clin Chem Lab Med. 2011
PubMed ID: 21342022
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.
Xu X, Zhou H, Boyer TG
EMBO Rep. 2011
PubMed ID: 21293490
Apo-Eε4 allele in conjunction with Aβ42 and tau in CSF: biomarker for Alzheimer's disease.
Kandimalla RJ, Prabhakar S, Binukumar BK, Wani WY, Gupta N, Sharma DR, Sunkaria A, Grover VK, Bhardwaj N, Jain K, Gill KD
Curr Alzheimer Res. 2011
PubMed ID: 21222606
Neurofibromin and amyloid precursor protein expression in dopamine D3 receptor knock-out mice brains.
Castorina A, Leggio GM, Giunta S, Magro G, Scapagnini G, Drago F, D'Agata V
Neurochem Res. 2011
PubMed ID: 21170735
Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier.
Paris D, Bachmeier C, Patel N, Quadros A, Volmar CH, Laporte V, Ganey J, Beaulieu-Abdelahad D, Ait-Ghezala G, Crawford F, Mullan MJ
Mol Med. 2011
PubMed ID: 21170472
Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets.
Canobbio I, Catricalà S, Balduini C, Torti M
Biochim Biophys Acta. 2011
PubMed ID: 21167219
Activation of amyloid precursor protein processing by growth factors is dependent on Ras GTPase activity.
Amigoni L, Ceriani M, Belotti F, Minopoli G, Martegani E
Neurochem Res. 2011
PubMed ID: 21161594
Insights into the thermodynamics of copper association with amyloid-β, α-synuclein and prion proteins.
Hong L, Simon JD
Metallomics. 2011
PubMed ID: 21116546
APP involvement in retinogenesis of mice.
Dinet V, An N, Ciccotosto GD, Bruban J, Maoui A, Bellingham SA, Hill AF, Andersen OM, Nykjaer A, Jonet L, Cappai R, Mascarelli F
Acta Neuropathol. 2011
PubMed ID: 20978902
Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.
Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH, Marr RA
J Mol Neurosci. 2011
PubMed ID: 20941644
Glial amyloid precursor protein expression is restricted to astrocytes in an experimental toxic model of multiple sclerosis.
Clarner T, Buschmann JP, Beyer C, Kipp M
J Mol Neurosci. 2011
PubMed ID: 20607446
Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line.
Czvitkovich S, Duller S, Mathiesen E, Lorenzoni K, Imbimbo BP, Hutter-Paier B, Windisch M, Wronski R
J Mol Neurosci. 2011
PubMed ID: 20603724
Amyloid precursor protein (APP) mRNA level is higher in the old mouse cerebral cortex and is regulated by sex steroids.
Sivanandam TM, Thakur MK
J Mol Neurosci. 2011
PubMed ID: 20563761
Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes.
Nishitsuji K, Hosono T, Uchimura K, Michikawa M
J Biol Chem. 2011
PubMed ID: 21177248
Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.
Herskowitz JH, Seyfried NT, Gearing M, Kahn RA, Peng J, Levey AI, Lah JJ
J Biol Chem. 2011
PubMed ID: 21147781
Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.
Amtul Z, Uhrig M, Rozmahel RF, Beyreuther K
J Biol Chem. 2011
PubMed ID: 20971855
Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
Jawhar S, Wirths O, Schilling S, Graubner S, Demuth HU, Bayer TA
J Biol Chem. 2011
PubMed ID: 21148560
Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.
Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA, Crowther DC
J Biol Chem. 2011
PubMed ID: 21147772
p75NTR regulates Abeta deposition by increasing Abeta production but inhibiting Abeta aggregation with its extracellular domain.
Wang YJ, Wang X, Lu JJ, Li QX, Gao CY, Liu XH, Sun Y, Yang M, Lim Y, Evin G, Zhong JH, Masters C, Zhou XF
J Neurosci. 2011
PubMed ID: 21307265
Bioluminescence imaging of Abeta deposition in bigenic mouse models of Alzheimer's disease.
Watts JC, Giles K, Grillo SK, Lemus A, DeArmond SJ, Prusiner SB
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21262831
The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.
Botev A, Munter LM, Wenzel R, Richter L, Althoff V, Ismer J, Gerling U, Weise C, Koksch B, Hildebrand PW, Bittl R, Multhaup G
Biochemistry. 2011
PubMed ID: 21186781
Aβ40(L17A/F19A) mutant diminishes the aggregation and neurotoxicity of Aβ40.
Chen YR, Huang HB, Lo CJ, Wang CC, Su CL, Liu HT, Shiao MS, Lin TH, Chen YC
Biochem Biophys Res Commun. 2011
PubMed ID: 21216230
Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.
Jürgensen S, Antonio LL, Mussi GE, Brito-Moreira J, Bomfim TR, De Felice FG, Garrido-Sanabria ER, Cavalheiro ÉA, Ferreira ST
J Biol Chem. 2011
PubMed ID: 21115476
Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.
Maezawa I, Zimin PI, Wulff H, Jin LW
J Biol Chem. 2011
PubMed ID: 20971854
Sphingolipid storage affects autophagic metabolism of the amyloid precursor protein and promotes Abeta generation.
Tamboli IY, Hampel H, Tien NT, Tolksdorf K, Breiden B, Mathews PM, Saftig P, Sandhoff K, Walter J
J Neurosci. 2011
PubMed ID: 21289194
In vivo fibrillar beta-amyloid detected using [11C]PiB positron emission tomography and neuropathologic assessment in older adults.
Sojkova J, Driscoll I, Iacono D, Zhou Y, Codispoti KE, Kraut MA, Ferrucci L, Pletnikova O, Mathis CA, Klunk WE, O'Brien RJ, Wong DF, Troncoso JC, Resnick SM
Arch Neurol. 2011
PubMed ID: 21320990
Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide.
Shruster A, Eldar-Finkelman H, Melamed E, Offen D
J Neurochem. 2011
PubMed ID: 21138436
Depletion of CXCR2 inhibits γ-secretase activity and amyloid-β production in a murine model of Alzheimer's disease.
Bakshi P, Margenthaler E, Reed J, Crawford F, Mullan M
Cytokine. 2011
PubMed ID: 21084199
Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.
Mohmmad Abdul H, Baig I, Levine H, Guttmann RP, Norris CM
Aging Cell. 2011
PubMed ID: 20969723
Striatal Aβ peptide deposition mirrors dementia and differentiates DLB and PDD from other parkinsonian syndromes.
Kalaitzakis ME, Walls AJ, Pearce RK, Gentleman SM
Neurobiol Dis. 2011
PubMed ID: 20951207
Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
Rönnbäck A, Zhu S, Dillner K, Aoki M, Lilius L, Näslund J, Winblad B, Graff C
Neurobiol Aging. 2011
PubMed ID: 19329229
Characterizing amyloid-beta protein misfolding from molecular dynamics simulations with explicit water.
Lee C, Ham S
J Comput Chem. 2011
PubMed ID: 20734314
MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.
Long JM, Lahiri DK
Biochem Biophys Res Commun. 2011
PubMed ID: 21172309
The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein.
Delarasse C, Auger R, Gonnord P, Fontaine B, Kanellopoulos JM
J Biol Chem. 2011
PubMed ID: 21081501
O-GlcNAcylation increases non-amyloidogenic processing of the amyloid-β precursor protein (APP).
Jacobsen KT, Iverfeldt K
Biochem Biophys Res Commun. 2011
PubMed ID: 21182826
Noninvasive magnetic resonance imaging detection of cerebral amyloid angiopathy-related microvascular alterations using superparamagnetic iron oxide particles in APP transgenic mouse models of Alzheimer's disease: application to passive Abeta immunotherap
Beckmann N, Gérard C, Abramowski D, Cannet C, Staufenbiel M
J Neurosci. 2011
PubMed ID: 21248127
Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline.
Yaffe K, Weston A, Graff-Radford NR, Satterfield S, Simonsick EM, Younkin SG, Younkin LH, Kuller L, Ayonayon HN, Ding J, Harris TB
JAMA. 2011
PubMed ID: 21245181
Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors.
Nicholson AM, Methner DN, Ferreira A
J Biol Chem. 2011
PubMed ID: 21047784
A role for FE65 in controlling GnRH-1 neurogenesis.
Forni PE, Fornaro M, Guénette S, Wray S
J Neurosci. 2011
PubMed ID: 21228158
Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients.
Kandimalla RJ, S P, Bk B, Wani WY, Sharma DR, Grover VK, Bhardwaj N, Jain K, Gill KD
Neurosci Lett. 2011
PubMed ID: 20599474
Stoichiometry and affinity of the human serum albumin-Alzheimer's Aβ peptide interactions.
Milojevic J, Melacini G
Biophys J. 2011
PubMed ID: 21190670
Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice.
Westmark CJ, Westmark PR, O'Riordan KJ, Ray BC, Hervey CM, Salamat MS, Abozeid SH, Stein KM, Stodola LA, Tranfaglia M, Burger C, Berry-Kravis EM, Malter JS
PLoS One. 2011
PubMed ID: 22046307
Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice.
Tran HT, Sanchez L, Esparza TJ, Brody DL
PLoS One. 2011
PubMed ID: 21980472
Amyloid-β-induced amyloid-β secretion: a possible feed-forward mechanism in Alzheimer’s disease.
Marsden IT, Minamide LS, Bamburg JR
J Alzheimers Dis. 2011
PubMed ID: 21961158
Soluble beta-amyloid precursor protein is related to disease progression in amyotrophic lateral sclerosis.
Steinacker P, Fang L, Kuhle J, Petzold A, Tumani H, Ludolph AC, Otto M, Brettschneider J
PLoS One. 2011
PubMed ID: 21858182
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity.
Li B, Zhong L, Yang X, Andersson T, Huang M, Tang SJ
PLoS One. 2011
PubMed ID: 21857966
Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein.
Shimada H, Ataka S, Tomiyama T, Takechi H, Mori H, Miki T
Dement Geriatr Cogn Disord. 2011
PubMed ID: 21846988
TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease.
Song M, Jin J, Lim JE, Kou J, Pattanayak A, Rehman JA, Kim HD, Tahara K, Lalonde R, Fukuchi K
J Neuroinflammation. 2011
PubMed ID: 21827663
[Effect of Panax notoginseng saponins on APP gene transcription in the brain tissue of SAMP8].
Zhong ZG, Lv L, Chai LM, Wu DP, Zhang WY, Huang JL, Gang YW, Li F, Zu B
Zhong Yao Cai. 2011
PubMed ID: 21818973
S100B and APP promote a gliocentric shift and impaired neurogenesis in Down syndrome neural progenitors.
Lu J, Esposito G, Scuderi C, Steardo L, Delli-Bovi LC, Hecht JL, Dickinson BC, Chang CJ, Mori T, Sheen V
PLoS One. 2011
PubMed ID: 21779383
Decreased sAβPPβ, Aβ38, and Aβ40 cerebrospinal fluid levels in frontotemporal dementia.
Gabelle A, Roche S, Gény C, Bennys K, Labauge P, Tholance Y, Quadrio I, Tiers L, Gor B, Boulanghien J, Chaulet C, Vighetto A, Croisile B, Krolak-Salmon P, Perret-Liaudet A, Touchon J, Lehmann S
J Alzheimers Dis. 2011
PubMed ID: 21709372
Detection of amyloid-β protein precursor homo-interactions using beta-galactosidase enzyme fragment complementation.
So PP, Chen CD, Abraham CR
J Alzheimers Dis. 2011
PubMed ID: 21694460
Amyloid-β protein precursor family members: a review from homology to biological function.
Huang HC, Jiang ZF
J Alzheimers Dis. 2011
PubMed ID: 21694452
Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease.
Madsen K, Neumann WJ, Holst K, Marner L, Haahr MT, Lehel S, Knudsen GM, Hasselbalch SG
J Alzheimers Dis. 2011
PubMed ID: 21673407
APOE and AβPP gene variation in cortical and cerebrovascular amyloid-β pathology and Alzheimer's disease: a population-based analysis.
Peuralinna T, Tanskanen M, Mäkelä M, Polvikoski T, Paetau A, Kalimo H, Sulkava R, Hardy J, Lai SL, Arepalli S, Hernandez D, Traynor BJ, Singleton A, Tienari PJ, Myllykangas L
J Alzheimers Dis. 2011
PubMed ID: 21654062
APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.
Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L
EMBO J. 2011
PubMed ID: 21587206
Cholesterol and amyloid-β: evidence for a cross-talk between astrocytes and neuronal cells.
Canepa E, Borghi R, Viña J, Traverso N, Gambini J, Domenicotti C, Marinari UM, Poli G, Pronzato MA, Ricciarelli R
J Alzheimers Dis. 2011
PubMed ID: 21483097
High throughput monitoring of amyloid-β(42) assembly into soluble oligomers achieved by sensitive conformation state-dependent immunoassays.
Zhao WQ, Toolan D, Hepler RW, Wolfe AL, Yu Y, Price E, Uebele VN, Schachter JB, Reynolds IJ, Renger JJ, McCampbell A, Ray WJ
J Alzheimers Dis. 2011
PubMed ID: 21483096
The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.
Barbagallo AP, Wang Z, Zheng H, D'Adamio L
PLoS One. 2011
PubMed ID: 21445342
Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.
Aydin D, Filippov MA, Tschäpe JA, Gretz N, Prinz M, Eils R, Brors B, Müller UC
BMC Genomics. 2011
PubMed ID: 21435241
Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.
Adlard PA, Bica L, White AR, Nurjono M, Filiz G, Crouch PJ, Donnelly PS, Cappai R, Finkelstein DI, Bush AI
PLoS One. 2011
PubMed ID: 21412423
A longitudinal study of behavioral deficits in an AβPP transgenic mouse model of Alzheimer's disease.
Havas D, Hutter-Paier B, Ubhi K, Rockenstein E, Crailsheim K, Masliah E, Windisch M
J Alzheimers Dis. 2011
PubMed ID: 21403389
The influence of chronic cerebral hypoperfusion on cognitive function and amyloid β metabolism in APP overexpressing mice.
Yamada M, Ihara M, Okamoto Y, Maki T, Washida K, Kitamura A, Hase Y, Ito H, Takao K, Miyakawa T, Kalaria RN, Tomimoto H, Takahashi R
PLoS One. 2011
PubMed ID: 21305033
Microarray analysis on human neuroblastoma cells exposed to aluminum, β(1-42)-amyloid or the β(1-42)-amyloid aluminum complex.
Gatta V, Drago D, Fincati K, Valenti MT, Dalle Carbonare L, Sensi SL, Zatta P
PLoS One. 2011
PubMed ID: 21298039
Central angiotensin II stimulation promotes β amyloid production in Sprague Dawley rats.
Zhu D, Shi J, Zhang Y, Wang B, Liu W, Chen Z, Tong Q
PLoS One. 2011
PubMed ID: 21297982
Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.
Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT
PLoS One. 2011
PubMed ID: 21297948
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Neprilysin-2 is an important β-amyloid degrading enzyme.
Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA
Am J Pathol. 2011
PubMed ID: 21224067
Cerebrospinal fluid tau, p-tau 181 and amyloid-β38/40/42 in frontotemporal dementias and primary progressive aphasias.
Bibl M, Mollenhauer B, Lewczuk P, Esselmann H, Wolf S, Otto M, Kornhuber J, Rüther E, Wiltfang J
Dement Geriatr Cogn Disord. 2011
PubMed ID: 21135556
Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.
Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT
J Alzheimers Dis. 2011
PubMed ID: 21116050
In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.
Smith P, Al Hashimi A, Girard J, Delay C, Hébert SS
J Neurochem. 2011
PubMed ID: 21062284
Study of the interaction between the amyloid beta peptide (1-40) and antioxidant compounds by nuclear magnetic resonance spectroscopy.
Galanakis PA, Bazoti FN, Bergquist J, Markides K, Spyroulias GA, Tsarbopoulos A
Biopolymers. 2011
PubMed ID: 21053258
Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing.
Eckert GP, Chang S, Eckmann J, Copanaki E, Hagl S, Hener U, Müller WE, Kögel D
Biochim Biophys Acta. 2011
PubMed ID: 21036142
β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease.
Wan L, Nie G, Zhang J, Luo Y, Zhang P, Zhang Z, Zhao B
Free Radic Biol Med. 2011
PubMed ID: 21034809
Effect of trehalose on the interaction of Alzheimer's Aβ-peptide and anionic lipid monolayers.
Izmitli A, Schebor C, McGovern MP, Reddy AS, Abbott NL, de Pablo JJ
Biochim Biophys Acta. 2011
PubMed ID: 20920466
Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein.
Pavlov PF, Wiehager B, Sakai J, Frykman S, Behbahani H, Winblad B, Ankarcrona M
FASEB J. 2011
PubMed ID: 20833873
Tau, prions and Aβ: the triad of neurodegeneration.
Reiniger L, Lukic A, Linehan J, Rudge P, Collinge J, Mead S, Brandner S
Acta Neuropathol. 2011
PubMed ID: 20473510
GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.
Cheng S, Li L, He S, Liu J, Sun Y, He M, Grasing K, Premont RT, Suo WZ
J Biol Chem. 2010
PubMed ID: 21041302
Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease.
Sarell CJ, Wilkinson SR, Viles JH
J Biol Chem. 2010
PubMed ID: 20974842
Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L, Bayer TA
J Biol Chem. 2010
PubMed ID: 20971852
The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.
Belyaev ND, Kellett KA, Beckett C, Makova NZ, Revett TJ, Nalivaeva NN, Hooper NM, Turner AJ
J Biol Chem. 2010
PubMed ID: 20961856
Intrinsic linear heterogeneity of amyloid {beta} protein fibrils revealed by higher resolution mass-per-length determinations.
Komatsu H, Feingold-Link E, Sharp KA, Rastogi T, Axelsen PH
J Biol Chem. 2010
PubMed ID: 20940298
Decreased clearance of CNS beta-amyloid in Alzheimer's disease.
Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, Morris JC, Yarasheski KE, Bateman RJ
Science. 2010
PubMed ID: 21148344
β-Barrel topology of Alzheimer's β-amyloid ion channels.
Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R
J Mol Biol. 2010
PubMed ID: 20970427
Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form.
Kitazume S, Tachida Y, Kato M, Yamaguchi Y, Honda T, Hashimoto Y, Wada Y, Saito T, Iwata N, Saido T, Taniguchi N
J Biol Chem. 2010
PubMed ID: 20952385
Alzheimer's disease peptide beta-amyloid interacts with fibrinogen and induces its oligomerization.
Ahn HJ, Zamolodchikov D, Cortes-Canteli M, Norris EH, Glickman JF, Strickland S
Proc Natl Acad Sci U S A. 2010
PubMed ID: 21098282
Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.
Austin SA, Santhanam AV, Katusic ZS
Circ Res. 2010
PubMed ID: 21127294
Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.
Habib LK, Lee MT, Yang J
J Biol Chem. 2010
PubMed ID: 20923778
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.
Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G
J Biol Chem. 2010
PubMed ID: 20921220
Mechanism of fiber assembly: treatment of Aβ peptide aggregation with a coarse-grained united-residue force field.
Rojas A, Liwo A, Browne D, Scheraga HA
J Mol Biol. 2010
PubMed ID: 20888834
Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
Tang CE, Guan YJ, Yi B, Li XH, Liang K, Zou HY, Yi H, Li MY, Zhang PF, Li C, Peng F, Chen ZC, Yao KT, Xiao ZQ
J Proteome Res. 2010
PubMed ID: 20882990
Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease.
Ongali B, Nicolakakis N, Lecrux C, Aboulkassim T, Rosa-Neto P, Papadopoulos P, Tong XK, Hamel E
Am J Pathol. 2010
PubMed ID: 21088218
Increased expression of β amyloid precursor gene in the hippocampus of streptozotocin-induced diabetic mice with memory deficit and anxiety induction.
Jung SW, Han OK, Kim SJ
J Neural Transm. 2010
PubMed ID: 21069392
Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology.
Schettini G, Govoni S, Racchi M, Rodriguez G
J Neurochem. 2010
PubMed ID: 21039524
Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model.
Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto-Watanabe Y, Kurata T, Abe K, Ikeda M, Westaway D, Murakami T, Hyslop PS, Matsubara E, Shoji M
J Neurosci Res. 2010
PubMed ID: 20936700
A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease.
Brohede J, Rinde M, Winblad B, Graff C
J Neurogenet. 2010
PubMed ID: 20919856
Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
Tamboli IY, Barth E, Christian L, Siepmann M, Kumar S, Singh S, Tolksdorf K, Heneka MT, Lütjohann D, Wunderlich P, Walter J
J Biol Chem. 2010
PubMed ID: 20876579
Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.
Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM
J Biol Chem. 2010
PubMed ID: 20864542
β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration.
Caušević M, Farooq U, Lovestone S, Killick R
Neurosci Lett. 2010
PubMed ID: 20826196
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.
Bordji K, Becerril-Ortega J, Nicole O, Buisson A
J Neurosci. 2010
PubMed ID: 21106831
A strategy for designing a peptide probe for detection of β-amyloid oligomers.
Hu Y, Su B, Kim CS, Hernandez M, Rostagno A, Ghiso J, Kim JR
Chembiochem. 2010
PubMed ID: 21031399
Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
Norstrom EM, Zhang C, Tanzi R, Sisodia SS
J Neurosci. 2010
PubMed ID: 21084623
N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly.
Liao MC, Hoos MD, Aucoin D, Ahmed M, Davis J, Smith SO, Van Nostrand WE
J Biol Chem. 2010
PubMed ID: 20807757
DHPC strongly affects the structure and oligomerization propensity of Alzheimer's Aβ(1-40) peptide.
Dahse K, Garvey M, Kovermann M, Vogel A, Balbach J, Fändrich M, Fahr A
J Mol Biol. 2010
PubMed ID: 20851128
I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.
Subramanian S, Mishra PK, Bandopadhyay D
Indian J Exp Biol. 2010
PubMed ID: 21117449
Prion-like aggregates: infectious agents in human disease.
Westermark GT, Westermark P
Trends Mol Med. 2010
PubMed ID: 20870462
CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT
Am J Pathol. 2010
PubMed ID: 20864679
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Xu W, Zhan Y, Huang W, Wang X, Zhang S, Lei H
J Neurosci Res. 2010
PubMed ID: 20806406
Larger temporal volume in elderly with high versus low beta-amyloid deposition.
Chételat G, Villemagne VL, Pike KE, Baron JC, Bourgeat P, Jones G, Faux NG, Ellis KA, Salvado O, Szoeke C, Martins RN, Ames D, Masters CL, Rowe CC, Australian Imaging Biomarkers and Lifestyle Study of Ageing (AIBL) Research Group
Brain. 2010
PubMed ID: 20739349
The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following β-amyloid peptide exposure.
Mairuae N, Hall Ii EC, Cheepsunthorn P, Lee SY, Connor JR
J Neurosci Res. 2010
PubMed ID: 20734416
The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.
Davis W
Curr Alzheimer Res. 2010
PubMed ID: 20704561
Stability of Aβ (1-42) peptide fibrils as consequence of environmental modifications.
Gregori M, Cassina V, Brogioli D, Salerno D, De Kimpe L, Scheper W, Masserini M, Mantegazza F
Eur Biophys J. 2010
PubMed ID: 20694815
Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis, on processing of the β-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.
Bürger S, Yafai Y, Bigl M, Wiedemann P, Schliebs R
Int J Dev Neurosci. 2010
PubMed ID: 20656006
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.
Alvira-Botero X, Pérez-Gonzalez R, Spuch C, Vargas T, Antequera D, Garzón M, Bermejo-Pareja F, Carro E
Mol Cell Neurosci. 2010
PubMed ID: 20637285
Amyloid-β peptide alteration of tau exon-10 splicing via the GSK3β-SC35 pathway.
Chen KL, Yuan RY, Hu CJ, Hsu CY
Neurobiol Dis. 2010
PubMed ID: 20615469
In vivo effects of APP are not exacerbated by BACE2 co-overexpression: behavioural characterization of a double transgenic mouse model.
Azkona G, Levannon D, Groner Y, Dierssen M
Amino Acids. 2010
PubMed ID: 20596738
Amyloid-β precursor protein induces glial differentiation of neural progenitor cells by activation of the IL-6/gp130 signaling pathway.
Kwak YD, Dantuma E, Merchant S, Bushnev S, Sugaya K
Neurotox Res. 2010
PubMed ID: 20309664
Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice.
Austin SA, Combs CK
Neurobiol Aging. 2010
PubMed ID: 19058878
ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice.
Donkin JJ, Stukas S, Hirsch-Reinshagen V, Namjoshi D, Wilkinson A, May S, Chan J, Fan J, Collins J, Wellington CL
J Biol Chem. 2010
PubMed ID: 20739291
Mutations alter the geometry and mechanical properties of Alzheimer's Aβ(1-40) amyloid fibrils.
Paparcone R, Pires MA, Buehler MJ
Biochemistry. 2010
PubMed ID: 20731379
High cerebrospinal tau levels are associated with the rs242557 tau gene variant and low cerebrospinal β-amyloid in Parkinson disease.
Compta Y, Ezquerra M, Muñoz E, Tolosa E, Valldeoriola F, Rios J, Cámara A, Fernández M, Buongiorno MT, Marti MJ
Neurosci Lett. 2010
PubMed ID: 20951764
Trafficking of amyloid β-precursor protein products C83 and C99 on the endocytic pathway.
Hare J
Biochem Biophys Res Commun. 2010
PubMed ID: 20849818
Micelle-like architecture of the monomer ensemble of Alzheimer's amyloid-β peptide in aqueous solution and its implications for Aβ aggregation.
Vitalis A, Caflisch A
J Mol Biol. 2010
PubMed ID: 20709081
Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.
Tian Y, Crump CJ, Li YM
J Biol Chem. 2010
PubMed ID: 20675367
Biology of amyloid: structure, function, and regulation.
Greenwald J, Riek R
Structure. 2010
PubMed ID: 20947013
APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle.
Carter CJ
Neurosci Lett. 2010
PubMed ID: 20674675
Tau reduction prevents Abeta-induced defects in axonal transport.
Vossel KA, Zhang K, Brodbeck J, Daub AC, Sharma P, Finkbeiner S, Cui B, Mucke L
Science. 2010
PubMed ID: 20829454
Specific and efficient anti-Aβ42 antibodies induced by sixteen tandem repeats of Aβ9.
Cui L, Huang X, Wang J, Zhang Y
J Neuroimmunol. 2010
PubMed ID: 20599279
Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.
Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT
J Biol Chem. 2010
PubMed ID: 20558735
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B
EMBO J. 2010
PubMed ID: 20818335
Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells.
Lukiw WJ, Cui JG, Yuan LY, Bhattacharjee PS, Corkern M, Clement C, Kammerman EM, Ball MJ, Zhao Y, Sullivan PM, Hill JM
Neuroreport. 2010
PubMed ID: 20683212
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.
Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20855613
Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease.
Shin J, Yu SB, Yu UY, Jo SA, Ahn JH
BMB Rep. 2010
PubMed ID: 21034535
Regulation of β cleavage of amyloid precursor protein.
Wang JF, Lu R, Wang YZ
Neurosci Bull. 2010
PubMed ID: 20882069
Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H
J Biol Chem. 2010
PubMed ID: 20693289
The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer's beta-amyloid level and tau phosphorylation.
Huang X, Chen Y, Li WB, Cohen SN, Liao FF, Li L, Xu H, Zhang YW
Hum Mol Genet. 2010
PubMed ID: 20650958
Mechanisms and specificity of factor XIa and trypsin inhibition by protease nexin 2 and basic pancreatic trypsin inhibitor.
Navaneetham D, Sinha D, Walsh PN
J Biochem. 2010
PubMed ID: 20647553
Binding of nonsteroidal anti-inflammatory drugs to Abeta fibril.
Takeda T, Chang WE, Raman EP, Klimov DK
Proteins. 2010
PubMed ID: 20635343
Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease.
Matharu B, El-Agnaf O, Razvi A, Austen BM
Peptides. 2010
PubMed ID: 20633587
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Alzheimer's disease amyloid-beta peptide analogue alters the ps-dynamics of phospholipid membranes.
Buchsteiner A, Hauss T, Dante S, Dencher NA
Biochim Biophys Acta. 2010
PubMed ID: 20603101
Vascular response to acetazolamide decreases as a function of age in the arcA beta mouse model of cerebral amyloidosis.
Princz-Kranz FL, Mueggler T, Knobloch M, Nitsch RM, Rudin M
Neurobiol Dis. 2010
PubMed ID: 20600914
Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing.
Kwon OY, Hwang K, Kim JA, Kim K, Kwon IC, Song HK, Jeon H
J Cell Biochem. 2010
PubMed ID: 20568118
Circulating neprilysin clears brain amyloid.
Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB
Mol Cell Neurosci. 2010
PubMed ID: 20558294
MEGF10 functions as a receptor for the uptake of amyloid-β.
Singh TD, Park SY, Bae JS, Yun Y, Bae YC, Park RW, Kim IS
FEBS Lett. 2010
PubMed ID: 20828568
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI
Cell. 2010
PubMed ID: 20817278
Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis.
Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E
J Neurosci. 2010
PubMed ID: 20844121
Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.
Zhang C, Browne A, Child D, Tanzi RE
J Biol Chem. 2010
PubMed ID: 20622013
Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.
Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG
J Biol Chem. 2010
PubMed ID: 20595388
The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, Takeda M
Psychogeriatrics. 2010
PubMed ID: 20860566
A nonhuman primate model of Alzheimer's disease generated by intracranial injection of amyloid-β42 and thiorphan.
Li W, Wu Y, Min F, Li Z, Huang J, Huang R
Metab Brain Dis. 2010
PubMed ID: 20838863
Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.
McMains VC, Myre M, Kreppel L, Kimmel AR
Dis Model Mech. 2010
PubMed ID: 20699477
ADDLs and the signaling web that leads to Alzheimer's disease.
Krafft GA, Klein WL
Neuropharmacology. 2010
PubMed ID: 20650286
Beta-like hippocampal network activity is differentially affected by amyloid beta peptides.
Adaya-Villanueva A, Ordaz B, Balleza-Tapia H, Márquez-Ramos A, Peña-Ortega F
Peptides. 2010
PubMed ID: 20558221
Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implications.
Lahiri DK, Maloney B
Exp Neurol. 2010
PubMed ID: 20451519
Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity.
Wang D, Govindaiah G, Liu R, De Arcangelis V, Cox CL, Xiang YK
FASEB J. 2010
PubMed ID: 20395454
DHEA prevents Abeta(25-35)-impaired survival of newborn neurons in the dentate gyrus through a modulation of PI3K-Akt-mTOR signaling.
Li L, Xu B, Zhu Y, Chen L, Sokabe M, Chen L
Neuropharmacology. 2010
PubMed ID: 20167228
The functional neurophysiology of the amyloid precursor protein (APP) processing pathway.
Randall AD, Witton J, Booth C, Hynes-Allen A, Brown JT
Neuropharmacology. 2010
PubMed ID: 20167227
Brain atrophy in healthy aging is related to CSF levels of Aβ1-42.
Fjell AM, Walhovd KB, Fennema-Notestine C, McEvoy LK, Hagler DJ, Holland D, Blennow K, Brewer JB, Dale AM, Alzheimer's Disease Neuroimaging Initiative
Cereb Cortex. 2010
PubMed ID: 20051356
Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells.
Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A
J Biol Chem. 2010
PubMed ID: 20576603
Abeta(1-40) forms five distinct amyloid structures whose beta-sheet contents and fibril stabilities are correlated.
Kodali R, Williams AD, Chemuru S, Wetzel R
J Mol Biol. 2010
PubMed ID: 20600131
Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues.
Chen S, Yadav SP, Surewicz WK
J Biol Chem. 2010
PubMed ID: 20576610
ANS binding reveals common features of cytotoxic amyloid species.
Bolognesi B, Kumita JR, Barros TP, Esbjorner EK, Luheshi LM, Crowther DC, Wilson MR, Dobson CM, Favrin G, Yerbury JJ
ACS Chem Biol. 2010
PubMed ID: 20550130
Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.
Kodam A, Maulik M, Peake K, Amritraj A, Vetrivel KS, Thinakaran G, Vance JE, Kar S
Glia. 2010
PubMed ID: 20607864
The prion protein as a receptor for amyloid-beta.
Kessels HW, Nguyen LN, Nabavi S, Malinow R
Nature. 2010
PubMed ID: 20703260
Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines.
Lee KJ, Moussa CE, Lee Y, Sung Y, Howell BW, Turner RS, Pak DT, Hoe HS
Neuroscience. 2010
PubMed ID: 20451588
Hollow core of Alzheimer's Abeta42 amyloid observed by cryoEM is relevant at physiological pH.
Miller Y, Ma B, Tsai CJ, Nussinov R
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20660780
Hereditary cerebral hemorrhage with amyloidosis associated with the E693K mutation of APP.
Bugiani O, Giaccone G, Rossi G, Mangieri M, Capobianco R, Morbin M, Mazzoleni G, Cupidi C, Marcon G, Giovagnoli A, Bizzi A, Di Fede G, Puoti G, Carella F, Salmaggi A, Romorini A, Patruno GM, Magoni M, Padovani A, Tagliavini F
Arch Neurol. 2010
PubMed ID: 20697050
Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers.
Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME
Ann Neurol. 2010
PubMed ID: 20641005
Ventricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline.
Chou YY, Leporé N, Saharan P, Madsen SK, Hua X, Jack CR, Shaw LM, Trojanowski JQ, Weiner MW, Toga AW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative
Neurobiol Aging. 2010
PubMed ID: 20620663
Clathrin-dependent APP endocytosis and Abeta secretion are highly sensitive to the level of plasma membrane cholesterol.
Cossec JC, Simon A, Marquer C, Moldrich RX, Leterrier C, Rossier J, Duyckaerts C, Lenkei Z, Potier MC
Biochim Biophys Acta. 2010
PubMed ID: 20580937
Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2).
Inouye H, Gleason KA, Zhang D, Decatur SM, Kirschner DA
Proteins. 2010
PubMed ID: 20544966
Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins.
Nielsen HM, Mulder SD, Beliën JA, Musters RJ, Eikelenboom P, Veerhuis R
Glia. 2010
PubMed ID: 20544859
The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort.
Caroli A, Frisoni GB, Alzheimer's Disease Neuroimaging Initiative
Neurobiol Aging. 2010
PubMed ID: 20538373
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects.
Apostolova LG, Hwang KS, Andrawis JP, Green AE, Babakchanian S, Morra JH, Cummings JL, Toga AW, Trojanowski JQ, Shaw LM, Jack CR, Petersen RC, Aisen PS, Jagust WJ, Koeppe RA, Mathis CA, Weiner MW, Thompson PM, Alzheimer's Disease Neuroimaging Initiative
Neurobiol Aging. 2010
PubMed ID: 20538372
Increased expression of the lysosomal cholesterol transporter NPC1 in Alzheimer's disease.
Kågedal K, Kim WS, Appelqvist H, Chan S, Cheng D, Agholme L, Barnham K, McCann H, Halliday G, Garner B
Biochim Biophys Acta. 2010
PubMed ID: 20497909
Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APP.
Hughes M, Snetkov V, Rose RS, Trousil S, Mermoud JE, Dingwall C
J Neurochem. 2010
PubMed ID: 20477946
sAPPalpha antagonizes dendritic degeneration and neuron death triggered by proteasomal stress.
Copanaki E, Chang S, Vlachos A, Tschäpe JA, Müller UC, Kögel D, Deller T
Mol Cell Neurosci. 2010
PubMed ID: 20472066
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.
Iijima K, Gatt A, Iijima-Ando K
Hum Mol Genet. 2010
PubMed ID: 20466736
Adult-onset hypothyroidism induces the amyloidogenic pathway of amyloid precursor protein processing in the rat hippocampus.
Ghenimi N, Alfos S, Redonnet A, Higueret P, Pallet V, Enderlin V
J Neuroendocrinol. 2010
PubMed ID: 20403092
Membrane rafts in Alzheimer's disease beta-amyloid production.
Vetrivel KS, Thinakaran G
Biochim Biophys Acta. 2010
PubMed ID: 20303415
Abeta polymerization through interaction with membrane gangliosides.
Matsuzaki K, Kato K, Yanagisawa K
Biochim Biophys Acta. 2010
PubMed ID: 20117237
The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia.
Spies PE, Slats D, Sjögren JM, Kremer BP, Verhey FR, Rikkert MG, Verbeek MM
Curr Alzheimer Res. 2010
PubMed ID: 20043812
Amyloid β oligomers decrease hippocampal spontaneous network activity in an age-dependent manner.
Balleza-Tapia H, Huanosta-Gutiérrez A, Márquez-Ramos A, Arias N, Peña F
Curr Alzheimer Res. 2010
PubMed ID: 20043810
Transgenic expression of human wild-type amyloid precursor protein decreases neurogenesis in the adult hippocampus.
Naumann N, Alpár A, Ueberham U, Arendt T, Gärtner U
Hippocampus. 2010
PubMed ID: 19714567
Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers.
Ladiwala AR, Lin JC, Bale SS, Marcelino-Cruz AM, Bhattacharya M, Dordick JS, Tessier PM
J Biol Chem. 2010
PubMed ID: 20511235
Regional metabolic alteration of Alzheimer's disease in mouse brain expressing mutant human APP-PS1 by 1H HR-MAS.
Woo DC, Lee SH, Lee DW, Kim SY, Kim GY, Rhim HS, Choi CB, Kim HY, Lee CU, Choe BY
Behav Brain Res. 2010
PubMed ID: 20307581
Amyloid beta precursor protein regulates male sexual behavior.
Park JH, Bonthius PJ, Tsai HW, Bekiranov S, Rissman EF
J Neurosci. 2010
PubMed ID: 20668181
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.
Donmez G, Wang D, Cohen DE, Guarente L
Cell. 2010
PubMed ID: 20655472
Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif.
Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G
J Biol Chem. 2010
PubMed ID: 20452985
Oligomerized Abeta25-35 induces increased tyrosine phosphorylation of NMDA receptor subunit 2A in rat hippocampal CA1 subfield.
Wu GM, Hou XY
Brain Res. 2010
PubMed ID: 20441772
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.
Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E
FEBS J. 2010
PubMed ID: 20573181
The London APP mutation (Val717Ile) associated with early shifting abilities and behavioral changes in two Italian families with early-onset Alzheimer's disease.
Talarico G, Piscopo P, Gasparini M, Salati E, Pignatelli M, Pietracupa S, Malvezzi-Campeggi L, Crestini A, Boschi S, Lenzi GL, Confaloni A, Bruno G
Dement Geriatr Cogn Disord. 2010
PubMed ID: 20523046
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
Koike MA, Green KN, Blurton-Jones M, Laferla FM
Am J Pathol. 2010
PubMed ID: 20472896
A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease.
Salek RM, Xia J, Innes A, Sweatman BC, Adalbert R, Randle S, McGowan E, Emson PC, Griffin JL
Neurochem Int. 2010
PubMed ID: 20398713
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid.
Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Akutsu H, Hayashi T
Free Radic Res. 2010
PubMed ID: 20370566
Regulation of cholesterol efflux by amyloid beta secretion.
Umeda T, Mori H, Zheng H, Tomiyama T
J Neurosci Res. 2010
PubMed ID: 20155813
Dynamin 1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.
Watanabe T, Iwasaki K, Takasaki K, Yamagata N, Fujino M, Nogami A, Ii M, Katsurabayashi S, Mishima K, Fujiwara M
J Neurosci Res. 2010
PubMed ID: 20127811
ß-amyloid-related peptides potentiate K+-evoked glutamate release from adult rat hippocampal slices.
Kabogo D, Rauw G, Amritraj A, Baker G, Kar S
Neurobiol Aging. 2010
PubMed ID: 18819729
Episodic memory deficits are not related to altered glutamatergic synaptic transmission and plasticity in the CA1 hippocampus of the APPswe/PS1δE9-deleted transgenic mice model of ß-amyloidosis.
Volianskis A, Køstner R, Mølgaard M, Hass S, Jensen MS
Neurobiol Aging. 2010
PubMed ID: 18790549
Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.
Christensen DZ, Bayer TA, Wirths O
Neurobiol Aging. 2010
PubMed ID: 18771817
Co-occurrence of Alzheimer's disease beta-amyloid and tau pathologies at synapses.
Takahashi RH, Capetillo-Zarate E, Lin MT, Milner TA, Gouras GK
Neurobiol Aging. 2010
PubMed ID: 18771816
LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation.
Okabayashi S, Kimura N
Neuroreport. 2010
PubMed ID: 20461023
Laser-induced propagation and destruction of amyloid beta fibrils.
Yagi H, Ozawa D, Sakurai K, Kawakami T, Kuyama H, Nishimura O, Shimanouchi T, Kuboi R, Naiki H, Goto Y
J Biol Chem. 2010
PubMed ID: 20406822
MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons.
Vilardo E, Barbato C, Ciotti M, Cogoni C, Ruberti F
J Biol Chem. 2010
PubMed ID: 20395292
Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5.
Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A
Neuron. 2010
PubMed ID: 20547131
Fibrinogen and beta-amyloid association alters thrombosis and fibrinolysis: a possible contributing factor to Alzheimer's disease.
Cortes-Canteli M, Paul J, Norris EH, Bronstein R, Ahn HJ, Zamolodchikov D, Bhuvanendran S, Fenz KM, Strickland S
Neuron. 2010
PubMed ID: 20547128
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H
J Biol Chem. 2010
PubMed ID: 20348104
Increased tau phosphorylation and beta amyloid in the hipocampus of mouse pups by early life lead exposure.
Li N, Yu ZL, Wang L, Zheng YT, Jia JX, Wang Q, Zhu MJ, Liu XL, Xia X, Li WJ
Acta Biol Hung. 2010
PubMed ID: 20519167
Interaction of a novel mitochondrial protein, 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (NIPSNAP1), with the amyloid precursor protein family.
Tummala H, Li X, Homayouni R
Eur J Neurosci. 2010
PubMed ID: 20497468
hnRNP C promotes APP translation by competing with FMRP for APP mRNA recruitment to P bodies.
Lee EK, Kim HH, Kuwano Y, Abdelmohsen K, Srikantan S, Subaran SS, Gleichmann M, Mughal MR, Martindale JL, Yang X, Worley PF, Mattson MP, Gorospe M
Nat Struct Mol Biol. 2010
PubMed ID: 20473314
Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production.
Hooff GP, Peters I, Wood WG, Müller WE, Eckert GP
Mol Neurobiol. 2010
PubMed ID: 20405344
Density functional theory analysis and spectral studies on amyloid peptide Abeta(28-35) and its mutants A30G and A30I.
Nagarajan S, Rajadas J, Malar EJ
J Struct Biol. 2010
PubMed ID: 20188180
Wild type but not mutant APP is involved in protective adaptive responses against oxidants.
Cenini G, Maccarinelli G, Lanni C, Bonini SA, Ferrari-Toninelli G, Govoni S, Racchi M, Butterfield DA, Memo M, Uberti D
Amino Acids. 2010
PubMed ID: 20063202
Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study.
Haeffner F, Barnham KJ, Bush AI, Brinck T
J Mol Model. 2010
PubMed ID: 19924451
Soluble oligomeric forms of beta-amyloid (Abeta) peptide stimulate Abeta production via astrogliosis in the rat brain.
Perez JL, Carrero I, Gonzalo P, Arevalo-Serrano J, Sanz-Anquela JM, Ortega J, Rodriguez M, Gonzalo-Ruiz A
Exp Neurol. 2010
PubMed ID: 19879263
Abeta exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease.
Folwell J, Cowan CM, Ubhi KK, Shiabh H, Newman TA, Shepherd D, Mudher A
Exp Neurol. 2010
PubMed ID: 19782075
Somatostatin, tau, and beta-amyloid within the anterior olfactory nucleus in Alzheimer disease.
Saiz-Sanchez D, Ubeda-Bañon I, de la Rosa-Prieto C, Argandoña-Palacios L, Garcia-Muñozguren S, Insausti R, Martinez-Marcos A
Exp Neurol. 2010
PubMed ID: 19559700
Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling.
Ladner CL, Chen M, Smith DP, Platt GW, Radford SE, Langen R
J Biol Chem. 2010
PubMed ID: 20335170
Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study.
Bora RP, Prabhakar R
Biochemistry. 2010
PubMed ID: 20380468
Destabilizing Alzheimer's Abeta(42) protofibrils with morin: mechanistic insights from molecular dynamics simulations.
Lemkul JA, Bevan DR
Biochemistry. 2010
PubMed ID: 20369844
Effect of Naoling decoction on the expression of APP in hippocampal CA3 region in rats with synthetic Alzheimer's disease.
Zhong B, Wang Z, He M
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010
PubMed ID: 20543465
Learning discloses abnormal structural and functional plasticity at hippocampal synapses in the APP23 mouse model of Alzheimer's disease.
Middei S, Roberto A, Berretta N, Panico MB, Lista S, Bernardi G, Mercuri NB, Ammassari-Teule M, Nisticò R
Learn Mem. 2010
PubMed ID: 20404004
Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.
Ajmo JM, Bailey LA, Howell MD, Cortez LK, Pennypacker KR, Mehta HN, Morgan D, Gordon MN, Gottschall PE
J Neurochem. 2010
PubMed ID: 20180882
Behavioural phenotype of APPC100.V717F transgenic mice over-expressing a mutant Abeta-bearing fragment is associated with reduced NMDA receptor density.
Boon WC, van den Buuse M, Wegener N, Martin S, Chua HK, Bush AI, Masters CL, Adlard PA, Li QX
Behav Brain Res. 2010
PubMed ID: 20085783
Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice.
Vale C, Alonso E, Rubiolo JA, Vieytes MR, LaFerla FM, Giménez-Llort L, Botana LM
Cell Mol Neurobiol. 2010
PubMed ID: 19943189
Induction of terminal differentiation in melanoma cells on downregulation of beta-amyloid precursor protein.
Botelho MG, Wang X, Arndt-Jovin DJ, Becker D, Jovin TM
J Invest Dermatol. 2010
PubMed ID: 19759550
Amyloid-beta-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation.
Tai LM, Holloway KA, Male DK, Loughlin AJ, Romero IA
J Cell Mol Med. 2010
PubMed ID: 19438816
Calcium signaling and amyloid toxicity in Alzheimer disease.
Demuro A, Parker I, Stutzmann GE
J Biol Chem. 2010
PubMed ID: 20212036
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S
J Biol Chem. 2010
PubMed ID: 20178983
PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila.
Chiang HC, Wang L, Xie Z, Yau A, Zhong Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20351282
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes.
Takeda S, Sato N, Uchio-Yamada K, Sawada K, Kunieda T, Takeuchi D, Kurinami H, Shinohara M, Rakugi H, Morishita R
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20231468
Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ
J Biol Chem. 2010
PubMed ID: 20145246
Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli IY, Walter J, Wirths O, Bayer TA
J Biol Chem. 2010
PubMed ID: 20145244
A role for the high-density lipoprotein receptor SR-B1 in synovial inflammation via serum amyloid-A.
Mullan RH, McCormick J, Connolly M, Bresnihan B, Veale DJ, Fearon U
Am J Pathol. 2010
PubMed ID: 20304957
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model.
Kohjima M, Sun Y, Chan L
Endocrinology. 2010
PubMed ID: 20176720
Analysis of beta-amyloid (Abeta) deposition in the temporal lobe in Alzheimer's disease using Fourier (spectral) analysis.
Armstrong RA, Cairns NJ
Neuropathol Appl Neurobiol. 2010
PubMed ID: 20132489
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Morinaga A, Hasegawa K, Nomura R, Ookoshi T, Ozawa D, Goto Y, Yamada M, Naiki H
Biochim Biophys Acta. 2010
PubMed ID: 20100601
Cell-type dependent modulation of Notch signaling by the amyloid precursor protein.
Oh SY, Chen CD, Abraham CR
J Neurochem. 2010
PubMed ID: 20089128
Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease.
Bader Lange ML, St Clair D, Markesbery WR, Studzinski CM, Murphy MP, Butterfield DA
Neurobiol Dis. 2010
PubMed ID: 20083199
Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation.
Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B
Stem Cells. 2010
PubMed ID: 20049903
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.
Mosconi L, Rinne JO, Tsui WH, Berti V, Li Y, Wang H, Murray J, Scheinin N, Någren K, Williams S, Glodzik L, De Santi S, Vallabhajosula S, de Leon MJ
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20231448
TAG-1 is an inhibitor of TGFbeta2-induced neuronal death via amyloid beta precursor protein.
Tachi N, Hashimoto Y, Nawa M, Matsuoka M
Biochem Biophys Res Commun. 2010
PubMed ID: 20184861
Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein.
Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20212142
The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H
J Biol Chem. 2010
PubMed ID: 20106965
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein.
Zhang C, Browne A, Child D, Divito JR, Stevenson JA, Tanzi RE
J Biol Chem. 2010
PubMed ID: 20097758
AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.
Vingtdeux V, Giliberto L, Zhao H, Chandakkar P, Wu Q, Simon JE, Janle EM, Lobo J, Ferruzzi MG, Davies P, Marambaud P
J Biol Chem. 2010
PubMed ID: 20080969
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation.
Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y
J Neurosci. 2010
PubMed ID: 20237263
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
Burgos PV, Mardones GA, Rojas AL, daSilva LL, Prabhu Y, Hurley JH, Bonifacino JS
Dev Cell. 2010
PubMed ID: 20230749
APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice.
Kotulska K, Larysz-Brysz M, LePecheur M, Marcol W, Lewin-Kowalik J, Paly E, London J
Brain Res Bull. 2010
PubMed ID: 19958821
The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.
Muirhead KE, Borger E, Aitken L, Conway SJ, Gunn-Moore FJ
Biochem J. 2010
PubMed ID: 20175748
The extracellular domain of Bri2 (ITM2B) binds the ABri peptide (1-23) and amyloid beta-peptide (Abeta1-40): Implications for Bri2 effects on processing of amyloid precursor protein and Abeta aggregation.
Peng S, Fitzen M, Jörnvall H, Johansson J
Biochem Biophys Res Commun. 2010
PubMed ID: 20036644
Conversion of Abeta42 into a folded soluble native-like protein using a semi-random library of amphipathic helices.
Arslan PE, Mulligan VK, Ho S, Chakrabartty A
J Mol Biol. 2010
PubMed ID: 20026077
Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.
Zhao WQ, Santini F, Breese R, Ross D, Zhang XD, Stone DJ, Ferrer M, Townsend M, Wolfe AL, Seager MA, Kinney GG, Shughrue PJ, Ray WJ
J Biol Chem. 2010
PubMed ID: 20032460
Blocking beta2-adrenergic receptor attenuates acute stress-induced amyloid beta peptides production.
Yu NN, Wang XX, Yu JT, Wang ND, Lu RC, Miao D, Tian Y, Tan L
Brain Res. 2010
PubMed ID: 20059989
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats.
Silverberg GD, Miller MC, Machan JT, Johanson CE, Caralopoulos IN, Pascale CL, Heile A, Klinge PM
Brain Res. 2010
PubMed ID: 20045398
Generation of conditional null alleles for APP and APLP2.
Mallm JP, Tschäpe JA, Hick M, Filippov MA, Müller UC
Genesis. 2010
PubMed ID: 20140888
The enhancement of amyloid precursor protein and beta-site amyloid cleavage enzyme 1 interaction: amyloid-beta production with aging.
Zou L, Yang R, Zhang P, Dai Y
Int J Mol Med. 2010
PubMed ID: 20127045
Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid beta formation in NT2N neurons.
Eftekharzadeh B, Maghsoudi N, Khodagholi F
Biochimie. 2010
PubMed ID: 20026169
Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment.
Hansson O, Zetterberg H, Vanmechelen E, Vanderstichele H, Andreasson U, Londos E, Wallin A, Minthon L, Blennow K
Neurobiol Aging. 2010
PubMed ID: 18486992
Evidence for dimeric BACE-mediated APP processing.
Jin S, Agerman K, Kolmodin K, Gustafsson E, Dahlqvist C, Jureus A, Liu G, Fälting J, Berg S, Lundkvist J, Lendahl U
Biochem Biophys Res Commun. 2010
PubMed ID: 20097169
Detergent-like interaction of Congo red with the amyloid beta peptide.
Lendel C, Bolognesi B, Wahlström A, Dobson CM, Gräslund A
Biochemistry. 2010
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Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death.
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Brain Res. 2010
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NMR characterization of the interactions between lyso-GM1 aqueous micelles and amyloid beta.
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FEBS Lett. 2010
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Biophysical characterization of Abeta42 C-terminal fragments: inhibitors of Abeta42 neurotoxicity.
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Biochemistry. 2010
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Possible involvement of NO/NOS signaling in hippocampal amyloid-beta production induced by transient focal cerebral ischemia in aged rats.
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Neurosci Lett. 2010
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[Effects of Valeriana amurensis on the expressions of beta-APP, Abeta(1-40) and caspase-3 in Alzheimer's disease model rat's brain].
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Zhong Yao Cai. 2010
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Conformations and biological activities of amyloid beta peptide 25-35.
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Curr Protein Pept Sci. 2010
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A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.
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Cell Res. 2010
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An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production.
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Nat Struct Mol Biol. 2010
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Amyloid beta from axons and dendrites reduces local spine number and plasticity.
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Nat Neurosci. 2010
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Changes in cell proliferation in the subventricular zone of the brain in adult rats given beta-amyloid peptide (25-35).
Stepanichev MY, Moiseeva YV, Lazareva NA, Onufriev MV, Gulyaeva NV
Neurosci Behav Physiol. 2010
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Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.
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Mol Biol Cell. 2010
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Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years.
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Neurobiol Aging. 2010
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Interaction between oligomers of stefin B and amyloid-beta in vitro and in cells.
Skerget K, Taler-Vercic A, Bavdek A, Hodnik V, Ceru S, Tusek-Znidaric M, Kumm T, Pitsi D, Pompe-Novak M, Palumaa P, Soriano S, Kopitar-Jerala N, Turk V, Anderluh G, Zerovnik E
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Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
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J Biol Chem. 2010
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The common architecture of cross-beta amyloid.
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J Mol Biol. 2010
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Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition.
Jiang Y, Mullaney KA, Peterhoff CM, Che S, Schmidt SD, Boyer-Boiteau A, Ginsberg SD, Cataldo AM, Mathews PM, Nixon RA
Proc Natl Acad Sci U S A. 2010
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CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.
Giedraitis V, Glaser A, Sarajärvi T, Brundin R, Gunnarsson MD, Schjeide BM, Tanzi RE, Helisalmi S, Pirttilä T, Kilander L, Lannfelt L, Soininen H, Bertram L, Ingelsson M, Hiltunen M
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Beta-amyloid causes depletion of synaptic vesicles leading to neurotransmission failure.
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J Biol Chem. 2010
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Association thermodynamics and conformational stability of beta-sheet amyloid beta(17-42) oligomers: effects of E22Q (Dutch) mutation and charge neutralization.
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The amyloid precursor protein/protease nexin 2 Kunitz inhibitor domain is a highly specific substrate of mesotrypsin.
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J Biol Chem. 2010
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Estrogen stimulates degradation of beta-amyloid peptide by up-regulating neprilysin.
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Cognitive deficits associated with alteration of synaptic metaplasticity precede plaque deposition in AβPP23 transgenic mice.
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J Alzheimers Dis. 2010
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Docosahexaenoic acid reduces amyloid-β(1-42) secretion in human AβPP-transfected CHO-cells by mechanisms other than inflammation related to PGE₂.
de Wilde MC, van der Beek EM, Kiliaan AJ, Leenders I, Kuipers AA, Kamphuis PJ, Broersen LM
J Alzheimers Dis. 2010
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Evaluation of CSF biomarkers as predictors of Alzheimer's disease: a clinical follow-up study of 4.7 years.
Hertze J, Minthon L, Zetterberg H, Vanmechelen E, Blennow K, Hansson O
J Alzheimers Dis. 2010
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Neurotransmitter phenotype differentiation and synapse formation of neural precursors engrafting in amyloid-β(1-40) injured rat hippocampus.
Li Z, Gao C, Huang H, Sun W, Yi H, Fan X, Xu H
J Alzheimers Dis. 2010
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Amyloid-β peptides in plasma and cognitive decline after 1 year follow-up in Alzheimer's disease patients.
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Modified immunotherapies against Alzheimer's disease: toward safer and effective amyloid clearance.
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J Alzheimers Dis. 2010
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Coronary artery bypass surgery provokes Alzheimer's disease-like changes in the cerebrospinal fluid.
Palotás A, Reis HJ, Bogáts G, Babik B, Racsmány M, Engvau L, Kecskeméti E, Juhász A, Vieira LB, Teixeira AL, Mukhamedyarovi MA, Rizvanov AA, Yalvaç ME, Guimarães MM, Ferreira CN, Zefirov AL, Kiyasov AP, Wang L, Janka Z, Kálmán J
J Alzheimers Dis. 2010
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Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.
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Cell Death Dis. 2010
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The concentration of soluble extracellular amyloid-β protein in acute brain slices from CRND8 mice.
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Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease.
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Alzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.
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Amyloid-β inhibits No-cGMP signaling in a CD36- and CD47-dependent manner.
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PLoS One. 2010
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The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β.
Han HE, Sellamuthu S, Shin BH, Lee YJ, Song S, Seo JS, Baek IS, Bae J, Kim H, Yoo YJ, Jung YK, Song WK, Han PL, Park WJ
PLoS One. 2010
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Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice.
Fiorentini A, Rosi MC, Grossi C, Luccarini I, Casamenti F
PLoS One. 2010
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Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
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PLoS One. 2010
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Zinc overload enhances APP cleavage and Aβ deposition in the Alzheimer mouse brain.
Wang CY, Wang T, Zheng W, Zhao BL, Danscher G, Chen YH, Wang ZY
PLoS One. 2010
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Β-amyloid 1-42 oligomers impair function of human embryonic stem cell-derived forebrain cholinergic neurons.
Wicklund L, Leão RN, Strömberg AM, Mousavi M, Hovatta O, Nordberg A, Marutle A
PLoS One. 2010
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Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease.
Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H, Koistinaho J, Koistinaho M
J Neuroinflammation. 2010
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Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.
Bittner T, Fuhrmann M, Burgold S, Ochs SM, Hoffmann N, Mitteregger G, Kretzschmar H, LaFerla FM, Herms J
PLoS One. 2010
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Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.
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PLoS One. 2010
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Amyloid-β oligomer specificity mediated by the IgM isotype--implications for a specific protective mechanism exerted by endogenous auto-antibodies.
Lindhagen-Persson M, Brännström K, Vestling M, Steinitz M, Olofsson A
PLoS One. 2010
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Screening for familial APP mutations in sporadic cerebral amyloid angiopathy.
Biffi A, Plourde A, Shen Y, Onofrio R, Smith EE, Frosch M, Prada CM, Gusella J, Greenberg SM, Rosand J
PLoS One. 2010
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APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells.
De Chiara G, Marcocci ME, Civitelli L, Argnani R, Piacentini R, Ripoli C, Manservigi R, Grassi C, Garaci E, Palamara AT
PLoS One. 2010
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Sex- and brain region-specific acceleration of β-amyloidogenesis following behavioral stress in a mouse model of Alzheimer's disease.
Devi L, Alldred MJ, Ginsberg SD, Ohno M
Mol Brain. 2010
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Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein.
Witton J, Brown JT, Jones MW, Randall AD
Mol Brain. 2010
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Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein.
Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T
BMC Genomics. 2010
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eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer's disease.
Bottley A, Phillips NM, Webb TE, Willis AE, Spriggs KA
PLoS One. 2010
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EEG, activity, and sleep architecture in a transgenic AβPPswe/PSEN1A246E Alzheimer's disease mouse.
Jyoti A, Plano A, Riedel G, Platt B
J Alzheimers Dis. 2010
PubMed ID: 20858963
Upregulation of presenilin 1 in brains of sporadic, late-onset Alzheimer's disease.
Borghi R, Piccini A, Barini E, Cirmena G, Guglielmotto M, Tamagno E, Fornaro M, Perry G, Smith MA, Garuti A, Tabaton M
J Alzheimers Dis. 2010
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Amyloid-β as a modulator of synaptic plasticity.
Parihar MS, Brewer GJ
J Alzheimers Dis. 2010
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Importance of the caspase cleavage site in amyloid-β protein precursor.
Bredesen DE, John V, Galvan V
J Alzheimers Dis. 2010
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Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes, but not in Alzheimer's disease transgenic mice.
Cruz NF, Ball KK, Dienel GA
ASN Neuro. 2010
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The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.
Chung RS, Howells C, Eaton ED, Shabala L, Zovo K, Palumaa P, Sillard R, Woodhouse A, Bennett WR, Ray S, Vickers JC, West AK
PLoS One. 2010
PubMed ID: 20711450
FAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis.
Stieren E, Werchan WP, El Ayadi A, Li F, Boehning D
PLoS One. 2010
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APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation.
Ghosal K, Stathopoulos A, Pimplikar SW
PLoS One. 2010
PubMed ID: 20689579
Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking.
Fuentealba RA, Liu Q, Zhang J, Kanekiyo T, Hu X, Lee JM, LaDu MJ, Bu G
PLoS One. 2010
PubMed ID: 20686698
A study of long-term potentiation in transgenic mice over-expressing mutant forms of both amyloid precursor protein and presenilin-1.
Fitzjohn SM, Kuenzi F, Morton RA, Rosahl TW, Lewis H, Smith D, Seabrook GR, Collingridge GL
Mol Brain. 2010
PubMed ID: 20630068
Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production.
Saito R, Kaneko M, Okuma Y, Nomura Y
J Pharmacol Sci. 2010
PubMed ID: 20606367
Amyloid-beta1-42 induces reactive oxygen species-mediated autophagic cell death in U87 and SH-SY5Y cells.
Wang H, Ma J, Tan Y, Wang Z, Sheng C, Chen S, Ding J
J Alzheimers Dis. 2010
PubMed ID: 20571221
Amyloid-beta decreases cell-surface AMPA receptors by increasing intracellular calcium and phosphorylation of GluR2.
Liu SJ, Gasperini R, Foa L, Small DH
J Alzheimers Dis. 2010
PubMed ID: 20571220
APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice.
Sharman MJ, Morici M, Hone E, Berger T, Taddei K, Martins IJ, Lim WL, Singh S, Wenk MR, Ghiso J, Buxbaum JD, Gandy S, Martins RN
J Alzheimers Dis. 2010
PubMed ID: 20555142
Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.
Netzer WJ, Powell C, Nong Y, Blundell J, Wong L, Duff K, Flajolet M, Greengard P
PLoS One. 2010
PubMed ID: 20532168
Alzheimer's disease amyloid-beta links lens and brain pathology in Down syndrome.
Moncaster JA, Pineda R, Moir RD, Lu S, Burton MA, Ghosh JG, Ericsson M, Soscia SJ, Mocofanescu A, Folkerth RD, Robb RM, Kuszak JR, Clark JI, Tanzi RE, Hunter DG, Goldstein LE
PLoS One. 2010
PubMed ID: 20502642
Activation of PERK signaling attenuates Abeta-mediated ER stress.
Lee do Y, Lee KS, Lee HJ, Kim do H, Noh YH, Yu K, Jung HY, Lee SH, Lee JY, Youn YC, Jeong Y, Kim DK, Lee WB, Kim SS
PLoS One. 2010
PubMed ID: 20463975
Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer disease.
Seo JS, Leem YH, Lee KW, Kim SW, Lee JK, Han PL
J Alzheimers Dis. 2010
PubMed ID: 20421695
Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.
Lanni C, Nardinocchi L, Puca R, Stanga S, Uberti D, Memo M, Govoni S, D'Orazi G, Racchi M
PLoS One. 2010
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Plasma amyloid-beta as a biomarker in Alzheimer's disease: the AIBL study of aging.
Lui JK, Laws SM, Li QX, Villemagne VL, Ames D, Brown B, Bush AI, De Ruyck K, Dromey J, Ellis KA, Faux NG, Foster J, Fowler C, Gupta V, Hudson P, Laughton K, Masters CL, Pertile K, Rembach A, Rimajova M, Rodrigues M, Rowe CC, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ward V, Martins RN, AIBL Research Group
J Alzheimers Dis. 2010
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L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.
Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, Knaus HG, Marksteiner J
J Alzheimers Dis. 2010
PubMed ID: 20413896
Spherulites of amyloid-beta42 in vitro and in Alzheimer's disease.
Exley C, House E, Collingwood JF, Davidson MR, Cannon D, Donald AM
J Alzheimers Dis. 2010
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Immunohistochemical visualization of amyloid-beta protein precursor and amyloid-beta in extra- and intracellular compartments in the human brain.
Aho L, Pikkarainen M, Hiltunen M, Leinonen V, Alafuzoff I
J Alzheimers Dis. 2010
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Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice.
Holm P, Ettrup A, Klein AB, Santini MA, El-Sayed M, Elvang AB, Stensbøl TB, Mikkelsen JD, Knudsen GM, Aznar S
J Alzheimers Dis. 2010
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Differential accumulation of secreted AbetaPP metabolites in ocular fluids.
Prakasam A, Muthuswamy A, Ablonczy Z, Greig NH, Fauq A, Rao KJ, Pappolla MA, Sambamurti K
J Alzheimers Dis. 2010
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Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution.
Rui Y, Gu J, Yu K, Hartzell HC, Zheng JQ
Mol Brain. 2010
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Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.
Gengler S, Hamilton A, Hölscher C
PLoS One. 2010
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gamma-Secretase dependent production of intracellular domains is reduced in adult compared to embryonic rat brain membranes.
Frånberg J, Karlström H, Winblad B, Tjernberg LO, Frykman S
PLoS One. 2010
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Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40.
Sondag CM, Combs CK
J Neuroinflammation. 2010
PubMed ID: 20302643
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD
PLoS One. 2010
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Genetic reductions of beta-site amyloid precursor protein-cleaving enzyme 1 and amyloid-beta ameliorate impairment of conditioned taste aversion memory in 5XFAD Alzheimer's disease model mice.
Devi L, Ohno M
Eur J Neurosci. 2010
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Alzheimer's disease and the amyloid-beta peptide.
Murphy MP, LeVine H
J Alzheimers Dis. 2010
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Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease.
Vanmierlo T, Bloks VW, van Vark-van der Zee LC, Rutten K, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch HW, Kuipers F, Lütjohann D, Mulder M
J Alzheimers Dis. 2010
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Changes in the expression of genes associated with intraneuronal amyloid-beta and tau in Alzheimer's disease.
Fujimura RK, Reiner T, Ma F, Phillips V, de las Pozas A, Dickson DW, Roos BA, Howard GA, Perez-Stable C
J Alzheimers Dis. 2010
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Neocortical variation of Abeta load in fully expressed, pure Alzheimer's disease.
Cupidi C, Capobianco R, Goffredo D, Marcon G, Ghetti B, Bugiani O, Tagliavini F, Giaccone G
J Alzheimers Dis. 2010
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Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Huesa G, Baltrons MA, Gómez-Ramos P, Morán A, García A, Hidalgo J, Francés S, Santpere G, Ferrer I, Galea E
J Alzheimers Dis. 2010
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Genetic regulatory network analysis for app based on genetical genomics approach.
Wang X, Chen Y, Wang X, Lu L
Exp Aging Res. 2010
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Methods and models in neurodegenerative and systemic protein aggregation diseases.
Brorsson AC, Kumita JR, MacLeod I, Bolognesi B, Speretta E, Luheshi LM, Knowles TP, Dobson CM, Crowther DC
Front Biosci. 2010
PubMed ID: 20036826
Clinical, neuropathologic, and biochemical profile of the amyloid precursor protein I716F mutation.
Guardia-Laguarta C, Pera M, Clarimón J, Molinuevo JL, Sánchez-Valle R, Lladó A, Coma M, Gómez-Isla T, Blesa R, Ferrer I, Lleó A
J Neuropathol Exp Neurol. 2010
PubMed ID: 20010303
Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer's disease cases.
Wirths O, Bethge T, Marcello A, Harmeier A, Jawhar S, Lucassen PJ, Multhaup G, Brody DL, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA
J Neural Transm. 2010
PubMed ID: 19823761
Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2.
Patel NS, Mathura VS, Bachmeier C, Beaulieu-Abdelahad D, Laporte V, Weeks O, Mullan M, Paris D
J Neurochem. 2010
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The effects of parkin suppression on the behaviour, amyloid processing, and cell survival in APP mutant transgenic mice.
Perucho J, Casarejos MJ, Rubio I, Rodriguez-Navarro JA, Gómez A, Ampuero I, Rodal I, Solano RM, Carro E, García de Yébenes J, Mena MA
Exp Neurol. 2010
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Protective effect of N-glycan bisecting GlcNAc residues on beta-amyloid production in Alzheimer's disease.
Akasaka-Manya K, Manya H, Sakurai Y, Wojczyk BS, Kozutsumi Y, Saito Y, Taniguchi N, Murayama S, Spitalnik SL, Endo T
Glycobiology. 2010
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Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.
Fossati S, Cam J, Meyerson J, Mezhericher E, Romero IA, Couraud PO, Weksler BB, Ghiso J, Rostagno A
FASEB J. 2010
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A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.
Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE
FASEB J. 2010
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Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.
Rosen KM, Moussa CE, Lee HK, Kumar P, Kitada T, Qin G, Fu Q, Querfurth HW
J Neurosci Res. 2010
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Beta-amyloid protein (25-35) disrupts hippocampal network activity: role of Fyn-kinase.
Peña F, Ordaz B, Balleza-Tapia H, Bernal-Pedraza R, Márquez-Ramos A, Carmona-Aparicio L, Giordano M
Hippocampus. 2010
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Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories.
Konietzko U, Goodger ZV, Meyer M, Kohli BM, Bosset J, Lahiri DK, Nitsch RM
Neurobiol Aging. 2010
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Novel mediators of amyloid precursor protein signaling.
Swistowski A, Zhang Q, Orcholski ME, Crippen D, Vitelli C, Kurakin A, Bredesen DE
J Neurosci. 2009
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Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.
Yang L, Wang Z, Wang B, Justice NJ, Zheng H
J Neurosci. 2009
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Biophysical analyses of synthetic amyloid-beta(1-42) aggregates before and after covalent cross-linking. Implications for deducing the structure of endogenous amyloid-beta oligomers.
Moore BD, Rangachari V, Tay WM, Milkovic NM, Rosenberry TL
Biochemistry. 2009
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Amyloid-beta expression in retrosplenial cortex of triple transgenic mice: relationship to cholinergic axonal afferents from medial septum.
Robertson RT, Baratta J, Yu J, LaFerla FM
Neuroscience. 2009
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Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.
Rohe M, Synowitz M, Glass R, Paul SM, Nykjaer A, Willnow TE
J Neurosci. 2009
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Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.
Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA
Proc Natl Acad Sci U S A. 2009
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Fibril fragmentation enhances amyloid cytotoxicity.
Xue WF, Hellewell AL, Gosal WS, Homans SW, Hewitt EW, Radford SE
J Biol Chem. 2009
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Pathology associated memory deficits in Swedish mutant genome-based amyloid precursor protein transgenic mice.
Hock BJ, Lattal KM, Kulnane LS, Abel T, Lamb BT
Curr Aging Sci. 2009
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High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types.
Villemagne VL, Ataka S, Mizuno T, Brooks WS, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O'Keefe GJ, Masters CL, Mori H, Rowe CC
Arch Neurol. 2009
PubMed ID: 20008660
Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition.
Storandt M, Mintun MA, Head D, Morris JC
Arch Neurol. 2009
PubMed ID: 20008651
Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.
Abramov E, Dolev I, Fogel H, Ciccotosto GD, Ruff E, Slutsky I
Nat Neurosci. 2009
PubMed ID: 19935655
Abeta(31-35)-induced neuronal apoptosis is mediated by JNK-dependent extrinsic apoptosis pathway.
Li LM, Liu QH, Qiao JT, Zhang C
Neurosci Bull. 2009
PubMed ID: 19927172
Beta-amyloid deposition and the aging brain.
Rodrigue KM, Kennedy KM, Park DC
Neuropsychol Rev. 2009
PubMed ID: 19908146
Cell-derived soluble oligomers of human amyloid-beta peptides disturb cellular homeostasis and induce apoptosis in primary hippocampal neurons.
Yang TT, Hsu CT, Kuo YM
J Neural Transm. 2009
PubMed ID: 19809865
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
Mitchell JC, Ariff BB, Yates DM, Lau KF, Perkinton MS, Rogelj B, Stephenson JD, Miller CC, McLoughlin DM
Hum Mol Genet. 2009
PubMed ID: 19744962
Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.
Tan J, Mao G, Cui MZ, Lamb B, Sy MS, Xu X
Neurobiol Dis. 2009
PubMed ID: 19716417
Divalent metal transporter 1 is involved in amyloid precursor protein processing and Abeta generation.
Zheng W, Xin N, Chi ZH, Zhao BL, Zhang J, Li JY, Wang ZY
FASEB J. 2009
PubMed ID: 19679638
Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease.
Zhang L, Postina R, Wang Y
Cell Mol Life Sci. 2009
PubMed ID: 19672558
The difference in gliosis induced by β-amyloid and Tau treatments in astrocyte cultures derived from senescence accelerated and normal mouse strains.
Lü L, Mak YT, Fang M, Yew DT
Biogerontology. 2009
PubMed ID: 19221889
CSF biomarker levels in early and late onset Alzheimer's disease.
Bouwman FH, Schoonenboom NS, Verwey NA, van Elk EJ, Kok A, Blankenstein MA, Scheltens P, van der Flier WM
Neurobiol Aging. 2009
PubMed ID: 18403055
Rck/p54 interacts with APP mRNA as part of a multi-protein complex and enhances APP mRNA and protein expression in neuronal cell lines.
Broytman O, Westmark PR, Gurel Z, Malter JS
Neurobiol Aging. 2009
PubMed ID: 18378046
Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.
Kanekiyo T, Bu G
J Biol Chem. 2009
PubMed ID: 19826010
Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease.
Nishida Y, Ito S, Ohtsuki S, Yamamoto N, Takahashi T, Iwata N, Jishage K, Yamada H, Sasaguri H, Yokota S, Piao W, Tomimitsu H, Saido TC, Yanagisawa K, Terasaki T, Mizusawa H, Yokota T
J Biol Chem. 2009
PubMed ID: 19679659
Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve.
Cohen AD, Price JC, Weissfeld LA, James J, Rosario BL, Bi W, Nebes RD, Saxton JA, Snitz BE, Aizenstein HA, Wolk DA, Dekosky ST, Mathis CA, Klunk WE
J Neurosci. 2009
PubMed ID: 19940172
Age-related changes in serum and brain levels of androgens in male Brown Norway rats.
Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike CJ
Neuroreport. 2009
PubMed ID: 19829160
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19901339
Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.
Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F, Ozmen L, Bluethmann H, Dröse S, Brandt U, Savaskan E, Czech C, Götz J, Eckert A
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19897719
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.
Noguchi A, Matsumura S, Dezawa M, Tada M, Yanazawa M, Ito A, Akioka M, Kikuchi S, Sato M, Ideno S, Noda M, Fukunari A, Muramatsu S, Itokazu Y, Sato K, Takahashi H, Teplow DB, Nabeshima Y, Kakita A, Imahori K, Hoshi M
J Biol Chem. 2009
PubMed ID: 19759000
Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells.
Austin SA, Sens MA, Combs CK
J Neurosci. 2009
PubMed ID: 19923279
Divergent pathways mediate spine alterations and cell death induced by amyloid-beta, wild-type tau, and R406W tau.
Tackenberg C, Brandt R
J Neurosci. 2009
PubMed ID: 19923278
Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle.
Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM
Science. 2009
PubMed ID: 19779148
The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.
Falsone SF, Kungl AJ, Rek A, Cappai R, Zangger K
J Biol Chem. 2009
PubMed ID: 19759002
Human serum albumin inhibits Abeta fibrillization through a "monomer-competitor" mechanism.
Milojevic J, Raditsis A, Melacini G
Biophys J. 2009
PubMed ID: 19883602
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease.
Roher AE, Maarouf CL, Sue LI, Hu Y, Wilson J, Beach TG
Biomarkers. 2009
PubMed ID: 19863188
Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice.
Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J, Tan Z
Am J Pathol. 2009
PubMed ID: 19834067
Microglia activated with the toll-like receptor 9 ligand CpG attenuate oligomeric amyloid {beta} neurotoxicity in in vitro and in vivo models of Alzheimer's disease.
Doi Y, Mizuno T, Maki Y, Jin S, Mizoguchi H, Ikeyama M, Doi M, Michikawa M, Takeuchi H, Suzumura A
Am J Pathol. 2009
PubMed ID: 19834064
Amyloid precursor protein is required for convergent-extension movements during Zebrafish development.
Joshi P, Liang JO, DiMonte K, Sullivan J, Pimplikar SW
Dev Biol. 2009
PubMed ID: 19664615
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM
Neurobiol Dis. 2009
PubMed ID: 19660551
Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.
Ghosal K, Vogt DL, Liang M, Shen Y, Lamb BT, Pimplikar SW
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19837693
TMP21 transmembrane domain regulates gamma-secretase cleavage.
Pardossi-Piquard R, Böhm C, Chen F, Kanemoto S, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE
J Biol Chem. 2009
PubMed ID: 19710022
Degradation of amyloid beta protein by purified myelin basic protein.
Liao MC, Ahmed M, Smith SO, Van Nostrand WE
J Biol Chem. 2009
PubMed ID: 19692707
Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production.
Eggert S, Midthune B, Cottrell B, Koo EH
J Biol Chem. 2009
PubMed ID: 19596858
Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway.
Goodger ZV, Rajendran L, Trutzel A, Kohli BM, Nitsch RM, Konietzko U
J Cell Sci. 2009
PubMed ID: 19773363
Identification and characterisation of the novel amyloid-beta peptide-induced protein p17.
Nehar S, Mishra M, Heese K
FEBS Lett. 2009
PubMed ID: 19755123
Pure progressive amnesia and the APPV717G mutation.
Knight WD, Ahsan RL, Jackson J, Cipolotti L, Warrington EK, Fox NC, Rossor MN
Alzheimer Dis Assoc Disord. 2009
PubMed ID: 19950418
Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis.
Pavlov PF, Hansson Petersen C, Glaser E, Ankarcrona M
J Cell Mol Med. 2009
PubMed ID: 19725915
Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.
Laky K, Annaert W, Fowlkes BJ
Int Immunol. 2009
PubMed ID: 19710207
Plasma beta-amyloid 1-40 is associated with the diffuse small vessel disease subtype.
Gomis M, Sobrino T, Ois A, Millán M, Rodríguez-Campello A, Pérez de la Ossa N, Rodríguez-González R, Jiménez-Conde J, Cuadrado-Godia E, Roquer J, Dávalos A
Stroke. 2009
PubMed ID: 19696416
Protein phosphatase 5 protects neurons against amyloid-beta toxicity.
Sanchez-Ortiz E, Hahm BK, Armstrong DL, Rossie S
J Neurochem. 2009
PubMed ID: 19686245
Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathways.
Jin HK, Bae JS, Furuya S, Carter JE
Cell Prolif. 2009
PubMed ID: 19614678
Vascular endothelial growth factor (VEGF) affects processing of amyloid precursor protein and beta-amyloidogenesis in brain slice cultures derived from transgenic Tg2576 mouse brain.
Bürger S, Noack M, Kirazov LP, Kirazov EP, Naydenov CL, Kouznetsova E, Yafai Y, Schliebs R
Int J Dev Neurosci. 2009
PubMed ID: 19589380
Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides.
Ghidoni R, Albertini V, Squitti R, Paterlini A, Bruno A, Bernardini S, Cassetta E, Rossini PM, Squitieri F, Benussi L, Binetti G
J Alzheimers Dis. 2009
PubMed ID: 19584443
Amyloid beta and impairment in multiple memory systems in older transgenic APP TgCRND8 mice.
Hanna A, Horne P, Yager D, Eckman C, Eckman E, Janus C
Genes Brain Behav. 2009
PubMed ID: 19531156
Intracellular amyloid beta interacts with SOD1 and impairs the enzymatic activity of SOD1: implications for the pathogenesis of amyotrophic lateral sclerosis.
Yoon EJ, Park HJ, Kim GY, Cho HM, Choi JH, Park HY, Jang JY, Rhim HS, Kang SM
Exp Mol Med. 2009
PubMed ID: 19478559
Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice.
Philipson O, Lannfelt L, Nilsson LN
FEBS Lett. 2009
PubMed ID: 19683527
Reelin signaling antagonizes beta-amyloid at the synapse.
Durakoglugil MS, Chen Y, White CL, Kavalali ET, Herz J
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805234
Non-fibrillar amyloid-beta peptide reduces NMDA-induced neurotoxicity, but not AMPA-induced neurotoxicity.
Niidome T, Goto Y, Kato M, Wang PL, Goh S, Tanaka N, Akaike A, Kihara T, Sugimoto H
Biochem Biophys Res Commun. 2009
PubMed ID: 19563781
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.
Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H
J Neurosci. 2009
PubMed ID: 19726636
Amyloid precursor protein, heat-shock proteins, and Bcl-2 form a complex in mitochondria and modulate mitochondria function and apoptosis in N2a cells.
Yang TT, Hsu CT, Kuo YM
Mech Ageing Dev. 2009
PubMed ID: 19622370
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model.
Choi JH, Berger JD, Mazzella MJ, Morales-Corraliza J, Cataldo AM, Nixon RA, Ginsberg SD, Levy E, Mathews PM
J Neurochem. 2009
PubMed ID: 19619138
Parkin promotes intracellular Abeta1-42 clearance.
Burns MP, Zhang L, Rebeck GW, Querfurth HW, Moussa CE
Hum Mol Genet. 2009
PubMed ID: 19483198
Gamma-secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior.
McLeod J, Curtis N, Lewis HD, Good MA, Fagan MJ, Genever PG
FASEB J. 2009
PubMed ID: 19376818
Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures.
Henriques AG, Vieira SI, da Cruz e Silva EF, da Cruz e Silva OA
J Mol Neurosci. 2009
PubMed ID: 19340611
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN
Neurobiol Aging. 2009
PubMed ID: 18192084
Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.
Sola Vigo F, Kedikian G, Heredia L, Heredia F, Añel AD, Rosa AL, Lorenzo A
Neurobiol Aging. 2009
PubMed ID: 18187234
Amino acid position-specific contributions to amyloid beta-protein oligomerization.
Maji SK, Ogorzalek Loo RR, Inayathullah M, Spring SM, Vollers SS, Condron MM, Bitan G, Loo JA, Teplow DB
J Biol Chem. 2009
PubMed ID: 19567875
Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy.
Chen B, Thurber KR, Shewmaker F, Wickner RB, Tycko R
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706519
Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease.
Jiang D, Li X, Williams R, Patel S, Men L, Wang Y, Zhou F
Biochemistry. 2009
PubMed ID: 19601593
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.
Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J
J Neurosci. 2009
PubMed ID: 19692615
The repeat domain of the melanosome fibril protein Pmel17 forms the amyloid core promoting melanin synthesis.
McGlinchey RP, Shewmaker F, McPhie P, Monterroso B, Thurber K, Wickner RB
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666488
Amyloid beta-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes.
Igbavboa U, Sun GY, Weisman GA, He Y, Wood WG
Neuroscience. 2009
PubMed ID: 19401218
Paradoxical condensation of copper with elevated beta-amyloid in lipid rafts under cellular copper deficiency conditions: implications for Alzheimer disease.
Hung YH, Robb EL, Volitakis I, Ho M, Evin G, Li QX, Culvenor JG, Masters CL, Cherny RA, Bush AI
J Biol Chem. 2009
PubMed ID: 19542222
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.
Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK
J Neurosci. 2009
PubMed ID: 19657023
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.
Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C
Hum Mutat. 2009
PubMed ID: 19462468
FAD-mutation of APP is associated with a loss of its synaptotrophic activity.
Seeger G, Gärtner U, Ueberham U, Rohn S, Arendt T
Neurobiol Dis. 2009
PubMed ID: 19450683
Antiparallel beta-sheet: a signature structure of the oligomeric amyloid beta-peptide.
Cerf E, Sarroukh R, Tamamizu-Kato S, Breydo L, Derclaye S, Dufrêne YF, Narayanaswami V, Goormaghtigh E, Ruysschaert JM, Raussens V
Biochem J. 2009
PubMed ID: 19435461
CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling.
Volmar CH, Ait-Ghezala G, Frieling J, Weeks OI, Mullan MJ
Exp Cell Res. 2009
PubMed ID: 19422822
AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model.
Hassan WM, Merin DA, Fonte V, Link CD
Hum Mol Genet. 2009
PubMed ID: 19414486
S655 phosphorylation enhances APP secretory traffic.
Vieira SI, Rebelo S, Domingues SC, da Cruz e Silva EF, da Cruz e Silva OA
Mol Cell Biochem. 2009
PubMed ID: 19381782
RAGE regulates BACE1 and Abeta generation via NFAT1 activation in Alzheimer's disease animal model.
Cho HJ, Son SM, Jin SM, Hong HS, Shin DH, Kim SJ, Huh K, Mook-Jung I
FASEB J. 2009
PubMed ID: 19332646
Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C
Gut. 2009
PubMed ID: 19240061
Amyloid precursor protein increases cortical neuron size in transgenic mice.
Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC
Neurobiol Aging. 2009
PubMed ID: 18304698
Ganglioside GM1 binding the N-terminus of amyloid precursor protein.
Zhang H, Ding J, Tian W, Wang L, Huang L, Ruan Y, Lu T, Sha Y, Zhang D
Neurobiol Aging. 2009
PubMed ID: 18077059
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.
Wang H, Wei B, Bismuth G, Rudd CE
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19617540
The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide.
Wu F, Matsuoka Y, Mattson MP, Yao PJ
Biochem Biophys Res Commun. 2009
PubMed ID: 19450545
Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.
Peng S, Garzon DJ, Marchese M, Klein W, Ginsberg SD, Francis BM, Mount HT, Mufson EJ, Salehi A, Fahnestock M
J Neurosci. 2009
PubMed ID: 19625522
Thyroid hormones reverse the UV-induced repression of APP in neuroblastoma cells.
Cuesta A, Zambrano A, López E, Pascual A
FEBS Lett. 2009
PubMed ID: 19563806
Oligomeric Abeta in Alzheimer's Disease: Relationship to Plaque and Tangle Pathology, APOE Genotype and Cerebral Amyloid Angiopathy.
van Helmond Z, Miners JS, Kehoe PG, Love S
Brain Pathol. 2009
PubMed ID: 19725829
Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}.
Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL
J Biol Chem. 2009
PubMed ID: 19406747
Influence of residue 22 on the folding, aggregation profile, and toxicity of the Alzheimer's amyloid beta peptide.
Perálvarez-Marín A, Mateos L, Zhang C, Singh S, Cedazo-Mínguez A, Visa N, Morozova-Roche L, Gräslund A, Barth A
Biophys J. 2009
PubMed ID: 19580765
Evidence for novel beta-sheet structures in Iowa mutant beta-amyloid fibrils.
Tycko R, Sciarretta KL, Orgel JP, Meredith SC
Biochemistry. 2009
PubMed ID: 19358576
Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease.
Bernstein SL, Dupuis NF, Lazo ND, Wyttenbach T, Condron MM, Bitan G, Teplow DB, Shea JE, Ruotolo BT, Robinson CV, Bowers MT
Nat Chem. 2009
PubMed ID: 20703363
ABAD: a potential therapeutic target for Abeta-induced mitochondrial dysfunction in Alzheimer's disease.
Marques AT, Fernandes PA, Ramos MJ
Mini Rev Med Chem. 2009
PubMed ID: 19601895
Alzheimer's disease genetic mutation evokes ultrastructural alterations: correlation to an intracellular Abeta deposition and the level of GSK-3beta-P(Y216) phosphorylated form.
Pajak B, Songin M, Strosznajder JB, Gajkowska B
Neurotoxicology. 2009
PubMed ID: 19501118
Overexpression of Tfam protects mitochondria against beta-amyloid-induced oxidative damage in SH-SY5Y cells.
Xu S, Zhong M, Zhang L, Wang Y, Zhou Z, Hao Y, Zhang W, Yang X, Wei A, Pei L, Yu Z
FEBS J. 2009
PubMed ID: 19496804
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A
J Neurochem. 2009
PubMed ID: 19457132
Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
Sevalle J, Ayral E, Hernandez JF, Martinez J, Checler F
J Neurochem. 2009
PubMed ID: 19457123
Abeta43 is more frequent than Abeta40 in amyloid plaque cores from Alzheimer disease brains.
Welander H, Frånberg J, Graff C, Sundström E, Winblad B, Tjernberg LO
J Neurochem. 2009
PubMed ID: 19457079
Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease.
Atamna H, Frey WH, Ko N
Arch Biochem Biophys. 2009
PubMed ID: 19454279
Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer's disease.
Marcello A, Wirths O, Schneider-Axmann T, Degerman-Gunnarsson M, Lannfelt L, Bayer TA
J Neural Transm. 2009
PubMed ID: 19415450
c-Abl modulates AICD dependent cellular responses: transcriptional induction and apoptosis.
Vázquez MC, Vargas LM, Inestrosa NC, Alvarez AR
J Cell Physiol. 2009
PubMed ID: 19306298
Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.
Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H
J Neurosci Res. 2009
PubMed ID: 19267423
Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells.
Spadoni O, Crestini A, Piscopo P, Malvezzi-Campeggi L, Carunchio I, Pieri M, Zona C, Confaloni A
Cell Mol Neurobiol. 2009
PubMed ID: 19214738
Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease.
Zhiyou C, Yong Y, Shanquan S, Jun Z, Liangguo H, Ling Y, Jieying L
Neurochem Res. 2009
PubMed ID: 19123057
Binding and uptake of A beta1-42 by primary human astrocytes in vitro.
Nielsen HM, Veerhuis R, Holmqvist B, Janciauskiene S
Glia. 2009
PubMed ID: 19062178
Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid.
Strozyk D, Launer LJ, Adlard PA, Cherny RA, Tsatsanis A, Volitakis I, Blennow K, Petrovitch H, White LR, Bush AI
Neurobiol Aging. 2009
PubMed ID: 18068270
Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.
Li L, Zhang X, Yang D, Luo G, Chen S, Le W
Neurobiol Aging. 2009
PubMed ID: 18063223
A transgenic rat model of Alzheimer's disease with extracellular Abeta deposition.
Flood DG, Lin YG, Lang DM, Trusko SP, Hirsch JD, Savage MJ, Scott RW, Howland DS
Neurobiol Aging. 2009
PubMed ID: 18053619
Repeated novel cage exposure-induced improvement of early Alzheimer's-like cognitive and amyloid changes in TASTPM mice is unrelated to changes in brain endocannabinoids levels.
Pardon MC, Sarmad S, Rattray I, Bates TE, Scullion GA, Marsden CA, Barrett DA, Lowe J, Kendall DA
Neurobiol Aging. 2009
PubMed ID: 18023506
Microscopic factors that control beta-sheet registry in amyloid fibrils formed by fragment 11-25 of amyloid beta peptide: insights from computer simulations.
Negureanu L, Baumketner A
J Mol Biol. 2009
PubMed ID: 19414017
Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells.
Zhu X, Zhou W, Cui Y, Zhu L, Li J, Xia Z, Shao B, Wang H, Chen H
Biochem Biophys Res Commun. 2009
PubMed ID: 19393223
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.
Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW
J Neurosci. 2009
PubMed ID: 19515914
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.
Matsuda S, Matsuda Y, D'Adamio L
J Biol Chem. 2009
PubMed ID: 19366692
Pharmacology of the intracellular pathways activated by amyloid beta protein.
Balleza-Tapia H, Peña F
Mini Rev Med Chem. 2009
PubMed ID: 19519498
Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta.
Liu ML, Liu MJ, Shen YF, Ryu H, Kim HJ, Klupsch K, Downward J, Hong ST
J Cell Sci. 2009
PubMed ID: 19435805
APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.
Breyhan H, Wirths O, Duan K, Marcello A, Rettig J, Bayer TA
Acta Neuropathol. 2009
PubMed ID: 19387667
Intracellular Abeta and C99 aggregates induce mitochondria-dependent cell death in human neuroglioma H4 cells through recruitment of the 20S proteasome subunits.
Park HJ, Kim SS, Kang S, Rhim H
Brain Res. 2009
PubMed ID: 19362074
Organoselenium (Sel-Plex diet) decreases amyloid burden and RNA and DNA oxidative damage in APP/PS1 mice.
Lovell MA, Xiong S, Lyubartseva G, Markesbery WR
Free Radic Biol Med. 2009
PubMed ID: 19303433
Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.
Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O
Mol Cell Neurosci. 2009
PubMed ID: 19281847
Deprivation-induced dendritic shrinkage might be oppositely affected by the expression of wild-type and mutated human amyloid precursor protein.
Alpár A, Naumann N, Ueberham U, Arendt T, Gärtner U
J Neurosci Res. 2009
PubMed ID: 19170186
Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form.
Sarell CJ, Syme CD, Rigby SE, Viles JH
Biochemistry. 2009
PubMed ID: 19338344
Abeta40, either soluble or aggregated, is a remarkably potent antioxidant in cell-free oxidative systems.
Baruch-Suchodolsky R, Fischer B
Biochemistry. 2009
PubMed ID: 19320465
Overexpression of amyloid precursor protein increases copper content in HEK293 cells.
Suazo M, Hodar C, Morgan C, Cerpa W, Cambiazo V, Inestrosa NC, Gonzalez M
Biochem Biophys Res Commun. 2009
PubMed ID: 19318086
Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP x PS1 mice using MRI.
Maheswaran S, Barjat H, Rueckert D, Bate ST, Howlett DR, Tilling L, Smart SC, Pohlmann A, Richardson JC, Hartkens T, Hill DL, Upton N, Hajnal JV, James MF
Brain Res. 2009
PubMed ID: 19272356
Experimental characterization of disordered and ordered aggregates populated during the process of amyloid fibril formation.
Carulla N, Zhou M, Arimon M, Gairí M, Giralt E, Robinson CV, Dobson CM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416886
Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices.
Smith JP, Lal V, Bowser D, Cappai R, Masters CL, Ciccotosto GD
Brain Res. 2009
PubMed ID: 19302985
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier.
Li M, Shang DS, Zhao WD, Tian L, Li B, Fang WG, Zhu L, Man SM, Chen YH
J Immunol. 2009
PubMed ID: 19380826
Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis.
Vattemi G, Nogalska A, King Engel W, D'Agostino C, Checler F, Askanas V
Acta Neuropathol. 2009
PubMed ID: 19280202
Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.
Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H
J Biol Chem. 2009
PubMed ID: 19276086
Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation.
Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE
J Biol Chem. 2009
PubMed ID: 19251705
Intracellular sAPP retention in response to Abeta is mapped to cytoskeleton-associated structures.
Henriques AG, Vieira SI, Crespo-López ME, Guiomar de Oliveira MA, da Cruz e Silva EF, da Cruz e Silva OA
J Neurosci Res. 2009
PubMed ID: 19105196
AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.
Xu F, Previti ML, Nieman MT, Davis J, Schmaier AH, Van Nostrand WE
J Neurosci. 2009
PubMed ID: 19403832
MCP-1 involvement in glial differentiation of neuroprogenitor cells through APP signaling.
Vrotsos EG, Kolattukudy PE, Sugaya K
Brain Res Bull. 2009
PubMed ID: 19185603
Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease.
Reiman EM, Chen K, Liu X, Bandy D, Yu M, Lee W, Ayutyanont N, Keppler J, Reeder SA, Langbaum JB, Alexander GE, Klunk WE, Mathis CA, Price JC, Aizenstein HJ, DeKosky ST, Caselli RJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19346482
{beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution.
Gu Z, Liu W, Yan Z
J Biol Chem. 2009
PubMed ID: 19240035
Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.
Santos SF, Pierrot N, Morel N, Gailly P, Sindic C, Octave JN
J Neurosci. 2009
PubMed ID: 19369541
Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.
Hoey SE, Williams RJ, Perkinton MS
J Neurosci. 2009
PubMed ID: 19357271
Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta.
Pigino G, Morfini G, Atagi Y, Deshpande A, Yu C, Jungbauer L, LaDu M, Busciglio J, Brady S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19321417
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
Cho DH, Nakamura T, Fang J, Cieplak P, Godzik A, Gu Z, Lipton SA
Science. 2009
PubMed ID: 19342591
Amyloid beta peptides trigger CD47-dependent mast cell secretory and phagocytic responses.
Niederhoffer N, Levy R, Sick E, Andre P, Coupin G, Lombard Y, Gies JP
Int J Immunopathol Pharmacol. 2009
PubMed ID: 19505377
Dysmorphic findings in two cases of abeta/hypobetalipoproteinemia.
Solomon BD, Mohan P, Tifft CJ
Clin Dysmorphol. 2009
PubMed ID: 19282754
Reduced amyloidogenic processing of the amyloid beta-protein precursor by the small-molecule Differentiation Inducing Factor-1.
Myre MA, Washicosky K, Moir RD, Tesco G, Tanzi RE, Wasco W
Cell Signal. 2009
PubMed ID: 19154786
Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection.
Khanlou N, Moore DJ, Chana G, Cherner M, Lazzaretto D, Dawes S, Grant I, Masliah E, Everall IP, HNRC Group
J Neurovirol. 2009
PubMed ID: 19115126
Protein kinase C-dependent alpha-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B.
Argellati F, Domenicotti C, Passalacqua M, Janda E, Melloni E, Marinari UM, Pronzato MA, Ricciarelli R
FASEB J. 2009
PubMed ID: 19103644
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks.
Stante M, Minopoli G, Passaro F, Raia M, Vecchio LD, Russo T
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19282473
The effects of amyloid precursor protein on postsynaptic composition and activity.
Hoe HS, Fu Z, Makarova A, Lee JY, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD, Vicini S, Pak DT, Rebeck GW
J Biol Chem. 2009
PubMed ID: 19164281
Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM.
Zhang R, Hu X, Khant H, Ludtke SJ, Chiu W, Schmid MF, Frieden C, Lee JM
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19264960
Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.
Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, Tanila H
J Neurosci. 2009
PubMed ID: 19295151
Effect of amyloid beta on capacitive calcium entry in neural 2a cells.
Niu Y, Su Z, Zhao C, Song B, Zhang X, Zhao N, Shen X, Gong Y
Brain Res Bull. 2009
PubMed ID: 19000747
A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
Di Fede G, Catania M, Morbin M, Rossi G, Suardi S, Mazzoleni G, Merlin M, Giovagnoli AR, Prioni S, Erbetta A, Falcone C, Gobbi M, Colombo L, Bastone A, Beeg M, Manzoni C, Francescucci B, Spagnoli A, Cantù L, Del Favero E, Levy E, Salmona M, Tagliavini F
Science. 2009
PubMed ID: 19286555
Amyloid beta induces cellular relocalization and production of agrin and glypican-1.
Timmer NM, van Horssen J, Otte-Holler I, Wilhelmus MM, David G, van Beers J, de Waal RM, Verbeek MM
Brain Res. 2009
PubMed ID: 19166823
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19228947
Structural characterization of a soluble amyloid beta-peptide oligomer.
Yu L, Edalji R, Harlan JE, Holzman TF, Lopez AP, Labkovsky B, Hillen H, Barghorn S, Ebert U, Richardson PL, Miesbauer L, Solomon L, Bartley D, Walter K, Johnson RW, Hajduk PJ, Olejniczak ET
Biochemistry. 2009
PubMed ID: 19216516
AbetaPP A713T Mutation in Late Onset Alzheimer's Disease with Cerebrovascular Lesions.
Bernardi L, Geracitano S, Colao R, Puccio G, Gallo M, Anfossi M, Frangipane F, Curcio SA, Mirabelli M, Tomaino C, Vasso F, Smirne N, Maletta R, Bruni AC
J Alzheimers Dis. 2009
PubMed ID: 19363265
Angiotensin II AT2 receptor oligomers mediate G-protein dysfunction in an animal model of Alzheimer disease.
AbdAlla S, Lother H, el Missiry A, Langer A, Sergeev P, el Faramawy Y, Quitterer U
J Biol Chem. 2009
PubMed ID: 19074441
Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75(NTR) interaction.
Fombonne J, Rabizadeh S, Banwait S, Mehlen P, Bredesen DE
Ann Neurol. 2009
PubMed ID: 19334058
Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.
Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM
J Alzheimers Dis. 2009
PubMed ID: 19276549
E22Q-mutant Abeta peptide (AbetaDutch) increases vascular but reduces parenchymal Abeta deposition.
Herzig MC, Eisele YS, Staufenbiel M, Jucker M
Am J Pathol. 2009
PubMed ID: 19218342
Assessment of beta-amyloid deposits in human brain: a study of the BrainNet Europe Consortium.
Alafuzoff I, Thal DR, Arzberger T, Bogdanovic N, Al-Sarraj S, Bodi I, Boluda S, Bugiani O, Duyckaerts C, Gelpi E, Gentleman S, Giaccone G, Graeber M, Hortobagyi T, Höftberger R, Ince P, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Pikkarainen M, Revesz T, Rozemuller A, Seilhean D, Schulz-Schaeffer W, Streichenberger N, Wharton SB, Kretzschmar H
Acta Neuropathol. 2009
PubMed ID: 19184666
JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.
Colombo A, Bastone A, Ploia C, Sclip A, Salmona M, Forloni G, Borsello T
Neurobiol Dis. 2009
PubMed ID: 19166938
The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells.
Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL, Mori H
Am J Pathol. 2009
PubMed ID: 19164507
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid.
Lee HK, Kumar P, Fu Q, Rosen KM, Querfurth HW
Mol Biol Cell. 2009
PubMed ID: 19144826
Intestinal uptake of amyloid beta protein through columnar epithelial cells in suckling mice.
Ano Y, Nakayama H, Sakudo A, Sawano Y, Tanokura M, Itohara S, Onodera T
Histol Histopathol. 2009
PubMed ID: 19130397
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.
Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B
Neurobiol Dis. 2009
PubMed ID: 19110058
Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.
Simón AM, Schiapparelli L, Salazar-Colocho P, Cuadrado-Tejedor M, Escribano L, López de Maturana R, Del Río J, Pérez-Mediavilla A, Frechilla D
Neurobiol Dis. 2009
PubMed ID: 19101630
Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease.
Filali M, Lalonde R, Rivest S
Genes Brain Behav. 2009
PubMed ID: 19077180
Inverse association of cortisol serum levels with T-tau, P-tau 181 and P-tau 231 peptide levels and T-tau/Abeta 1-42 ratios in CSF in patients with mild Alzheimer's disease dementia.
Laske C, Stransky E, Fritsche A, Eschweiler GW, Leyhe T
Eur Arch Psychiatry Clin Neurosci. 2009
PubMed ID: 18806919
Abeta(1-42) stimulated T cells express P-PKC-delta and P-PKC-zeta in Alzheimer disease.
Miscia S, Ciccocioppo F, Lanuti P, Velluto L, Bascelli A, Pierdomenico L, Genovesi D, Di Siena A, Santavenere E, Gambi F, Ausili-Cèfaro G, Grimley PM, Marchisio M, Gambi D
Neurobiol Aging. 2009
PubMed ID: 17850925
IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.
Araki W, Kume H, Oda A, Tamaoka A, Kametani F
Biochem Biophys Res Commun. 2009
PubMed ID: 19167357
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.
Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM
Nature. 2009
PubMed ID: 19242475
Effects of environmental enrichment and physical activity on neurogenesis in transgenic PS1/APP mice.
Catlow BJ, Rowe AR, Clearwater CR, Mamcarz M, Arendash GW, Sanchez-Ramos J
Brain Res. 2009
PubMed ID: 19135431
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M
Nature. 2009
PubMed ID: 19225519
Decrease of dynamin 2 levels in late-onset Alzheimer's disease alters Abeta metabolism.
Kamagata E, Kudo T, Kimura R, Tanimukai H, Morihara T, Sadik MG, Kamino K, Takeda M
Biochem Biophys Res Commun. 2009
PubMed ID: 19126407
Oligomeric amyloid-beta(1-42) induces THP-1 human monocyte adhesion and maturation.
Crouse NR, Ajit D, Udan ML, Nichols MR
Brain Res. 2009
PubMed ID: 19101527
Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts.
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G
J Biol Chem. 2009
PubMed ID: 19074428
Abnormal cleavage of APP impairs its functions in cell adhesion and migration.
Sheng B, Song B, Zheng Z, Zhou F, Lu G, Zhao N, Zhang X, Gong Y
Neurosci Lett. 2009
PubMed ID: 19056463
Expression of amyloid precursor protein after rat traumatic brain injury.
Itoh T, Satou T, Nishida S, Tsubaki M, Hashimoto S, Ito H
Neurol Res. 2009
PubMed ID: 19228461
A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.
Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ
Arch Neurol. 2009
PubMed ID: 19204155
O-Mannosylation is required for the solubilization of heterologously expressed human beta-amyloid precursor protein in Saccharomyces cerevisiae.
Murakami-Sekimata A, Sato K, Sato K, Takashima A, Nakano A
Genes Cells. 2009
PubMed ID: 19170767
Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy.
Zaghi J, Goldenson B, Inayathullah M, Lossinsky AS, Masoumi A, Avagyan H, Mahanian M, Bernas M, Weinand M, Rosenthal MJ, Espinosa-Jeffrey A, de Vellis J, Teplow DB, Fiala M
Acta Neuropathol. 2009
PubMed ID: 19139910
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.
Kaden D, Voigt P, Munter LM, Bobowski KD, Schaefer M, Multhaup G
J Cell Sci. 2009
PubMed ID: 19126676
Collagen VI protects neurons against Abeta toxicity.
Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu GQ, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L
Nat Neurosci. 2009
PubMed ID: 19122666
Novel polymorphisms of the amyloid precursor protein (APP) gene in Chinese/Taiwanese patients with Alzheimer's disease.
Thajeb P, Wang P, Chien CL, Harrigan R
J Clin Neurosci. 2009
PubMed ID: 19097908
Elucidation of O-glycosylation structures of the beta-amyloid precursor protein by liquid chromatography-mass spectrometry using electron transfer dissociation and collision induced dissociation.
Perdivara I, Petrovich R, Allinquant B, Deterding LJ, Tomer KB, Przybylski M
J Proteome Res. 2009
PubMed ID: 19093876
Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice.
Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN
J Neurochem. 2009
PubMed ID: 19046405
Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis.
Zheng L, Kågedal K, Dehvari N, Benedikz E, Cowburn R, Marcusson J, Terman A
Free Radic Biol Med. 2009
PubMed ID: 19038331
A new amyloid-like beta-aggregate with amyloid characteristics, except fibril morphology.
Chang ES, Liao TY, Lim TS, Fann W, Chen RP
J Mol Biol. 2009
PubMed ID: 19041877
p120 catenin recruits cadherins to gamma-secretase and inhibits production of Abeta peptide.
Kouchi Z, Barthet G, Serban G, Georgakopoulos A, Shioi J, Robakis NK
J Biol Chem. 2009
PubMed ID: 19008223
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G
J Biol Chem. 2009
PubMed ID: 19028695
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation.
Crouch PJ, Hung LW, Adlard PA, Cortes M, Lal V, Filiz G, Perez KA, Nurjono M, Caragounis A, Du T, Laughton K, Volitakis I, Bush AI, Li QX, Masters CL, Cappai R, Cherny RA, Donnelly PS, White AR, Barnham KJ
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19122148
Mitochondrial mislocalization underlies Abeta42-induced neuronal dysfunction in a Drosophila model of Alzheimer's disease.
Iijima-Ando K, Hearn SA, Shenton C, Gatt A, Zhao L, Iijima K
PLoS One. 2009
PubMed ID: 20016833
[Genetics of dementias, Part 4: a spectrum of mutations responsible for the familial autosomal dominant form of Alzheimer's disease]
Kowalska A
Postepy Hig Med Dosw (Online). 2009
PubMed ID: 20009122
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H
PLoS One. 2009
PubMed ID: 19936202
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O
PLoS One. 2009
PubMed ID: 19924286
MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta.
Westmark CJ, Westmark PR, Malter JS
Int J Clin Exp Pathol. 2009
PubMed ID: 19918329
Expression of complement system components during aging and amyloid deposition in APP transgenic mice.
Reichwald J, Danner S, Wiederhold KH, Staufenbiel M
J Neuroinflammation. 2009
PubMed ID: 19917141
Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.
Hureau C, Coppel Y, Dorlet P, Solari PL, Sayen S, Guillon E, Sabater L, Faller P
Angew Chem Int Ed Engl. 2009
PubMed ID: 19904787
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
Rahimi F, Murakami K, Summers JL, Chen CH, Bitan G
PLoS One. 2009
PubMed ID: 19901993
CD74 interacts with APP and suppresses the production of Abeta.
Matsuda S, Matsuda Y, D'Adamio L
Mol Neurodegener. 2009
PubMed ID: 19849849
Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine.
Galloway S, Takechi R, Pallebage-Gamarallage MM, Dhaliwal SS, Mamo JC
Lipids Health Dis. 2009
PubMed ID: 19845970
Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.
Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS
Genome Biol. 2009
PubMed ID: 19799774
AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, Borghgraef P, Devijver H, Filipkowski RK, Kaczmarek L, Kügler S, Van Leuven F
PLoS One. 2009
PubMed ID: 19794916
In vivo turnover of tau and APP metabolites in the brains of wild-type and Tg2576 mice: greater stability of sAPP in the beta-amyloid depositing mice.
Morales-Corraliza J, Mazzella MJ, Berger JD, Diaz NS, Choi JH, Levy E, Matsuoka Y, Planel E, Mathews PM
PLoS One. 2009
PubMed ID: 19771166
Plasma amyloid-beta peptide levels correlate with adipocyte amyloid precursor protein gene expression in obese individuals.
Lee YH, Martin JM, Maple RL, Tharp WG, Pratley RE
Neuroendocrinology. 2009
PubMed ID: 19672057
Cerebral amyloid angiopathy: a common cause of cerebral hemorrhage.
Pezzini A, Del Zotto E, Volonghi I, Giossi A, Costa P, Padovani A
Curr Med Chem. 2009
PubMed ID: 19601795
Iron regulatory protein 2 is involved in brain copper homeostasis.
Mueller C, Magaki S, Schrag M, Ghosh MC, Kirsch WM
J Alzheimers Dis. 2009
PubMed ID: 19584448
Cardiomyocyte contractile dysfunction in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
Turdi S, Guo R, Huff AF, Wolf EM, Culver B, Ren J
PLoS One. 2009
PubMed ID: 19551139
Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods.
Davis RC, Maloney MT, Minamide LS, Flynn KC, Stonebraker MA, Bamburg JR
J Alzheimers Dis. 2009
PubMed ID: 19542631
Oligomerization partially explains the lowering of Abeta42 in Alzheimer's disease cerebrospinal fluid.
Englund H, Degerman Gunnarsson M, Brundin RM, Hedlund M, Kilander L, Lannfelt L, Pettersson FE
Neurodegener Dis. 2009
PubMed ID: 19521063
Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors.
Tang BL
Cell Adh Migr. 2009
PubMed ID: 19372755
[Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin]
Sarantseva SV, Bol'shakova OI, Timoshenko SI, Rodin DI, Vitek MP, Shvartsman AL
Genetika. 2009
PubMed ID: 19239106
Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease.
Belyaev ND, Nalivaeva NN, Makova NZ, Turner AJ
EMBO Rep. 2009
PubMed ID: 19057576
Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes.
Pridgeon JW, Webber EA, Sha D, Li L, Chin LS
FEBS J. 2009
PubMed ID: 19019082
Exceptional amyloid beta peptide hydrolyzing activity of nonphysiological immunoglobulin variable domain scaffolds.
Taguchi H, Planque S, Sapparapu G, Boivin S, Hara M, Nishiyama Y, Paul S
J Biol Chem. 2008
PubMed ID: 18974093
The binding of thioflavin T and its neutral analog BTA-1 to protofibrils of the Alzheimer's disease Abeta(16-22) peptide probed by molecular dynamics simulations.
Wu C, Wang Z, Lei H, Duan Y, Bowers MT, Shea JE
J Mol Biol. 2008
PubMed ID: 18851978
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T
J Biol Chem. 2008
PubMed ID: 18845544
The low density lipoprotein receptor-related protein 1 mediates uptake of amyloid beta peptides in an in vitro model of the blood-brain barrier cells.
Yamada K, Hashimoto T, Yabuki C, Nagae Y, Tachikawa M, Strickland DK, Liu Q, Bu G, Basak JM, Holtzman DM, Ohtsuki S, Terasaki T, Iwatsubo T
J Biol Chem. 2008
PubMed ID: 18940800
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC
J Biol Chem. 2008
PubMed ID: 18922798
Phosphorylation of amyloid precursor protein (APP) at Tyr687 regulates APP processing by alpha- and gamma-secretase.
Takahashi K, Niidome T, Akaike A, Kihara T, Sugimoto H
Biochem Biophys Res Commun. 2008
PubMed ID: 18854169
Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations.
Van Broeck B, Vanhoutte G, Cuijt I, Pereson S, Joris G, Timmermans JP, Van der Linden A, Van Broeckhoven C, Kumar-Singh S
Neurosci Lett. 2008
PubMed ID: 18840503
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.
Wang X, Su B, Siedlak SL, Moreira PI, Fujioka H, Wang Y, Casadesus G, Zhu X
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19050078
Increased exploratory activity of APP23 mice in a novel environment is reversed by siRNA.
Senechal Y, Prut L, Kelly PH, Staufenbiel M, Natt F, Hoyer D, Wiessner C, Dev KK
Brain Res. 2008
PubMed ID: 18823960
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, Vitek MP
J Alzheimers Dis. 2008
PubMed ID: 19096157
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV
J Clin Invest. 2008
PubMed ID: 19033669
Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ
Mech Ageing Dev. 2008
PubMed ID: 18977241
Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.
Christensen DZ, Kraus SL, Flohr A, Cotel MC, Wirths O, Bayer TA
Acta Neuropathol. 2008
PubMed ID: 18974993
Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC).
Miklossy J, Steele JC, Yu S, McCall S, Sandberg G, McGeer EG, McGeer PL
Acta Neuropathol. 2008
PubMed ID: 18843496
Selective induction of calcineurin activity and signaling by oligomeric amyloid beta.
Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G
Aging Cell. 2008
PubMed ID: 18782350
C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65.
Lakshmana MK, Chen E, Yoon IS, Kang DE
J Cell Mol Med. 2008
PubMed ID: 18373737
Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils.
Paravastu AK, Leapman RD, Yau WM, Tycko R
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19015532
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models.
Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, Zhang Z, Wei S, Sun X, Chen CH, Zhou W, Wang K, Song W
J Exp Med. 2008
PubMed ID: 18955571
Sulfated polysaccharides promote the assembly of amyloid beta(1-42) peptide into stable fibrils of reduced cytotoxicity.
Bravo R, Arimon M, Valle-Delgado JJ, García R, Durany N, Castel S, Cruz M, Ventura S, Fernàndez-Busquets X
J Biol Chem. 2008
PubMed ID: 18819917
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM, Teplow DB
J Biol Chem. 2008
PubMed ID: 18815129
Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age.
Abdul HM, Sultana R, St Clair DK, Markesbery WR, Butterfield DA
Free Radic Biol Med. 2008
PubMed ID: 18762245
Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J
J Neurosci. 2008
PubMed ID: 19005074
Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease.
Ait-ghezala G, Abdullah L, Volmar CH, Paris D, Luis CA, Quadros A, Mouzon B, Mullan MA, Keegan AP, Parrish J, Crawford FC, Mathura VS, Mullan MJ
Cytokine. 2008
PubMed ID: 18835787
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K
EMBO Rep. 2008
PubMed ID: 18833287
Prion infection of mice transgenic for human APPSwe: increased accumulation of cortical formic acid extractable Abeta(1-42) and rapid scrapie disease development.
Baier M, Apelt J, Riemer C, Gültner S, Schwarz A, Bamme T, Burwinkel M, Schliebs R
Int J Dev Neurosci. 2008
PubMed ID: 18662767
Increased bisecting and core-fucosylated N-glycans on mutant human amyloid precursor proteins.
Akasaka-Manya K, Manya H, Sakurai Y, Wojczyk BS, Spitalnik SL, Endo T
Glycoconj J. 2008
PubMed ID: 18521746
Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells.
Kim HJ, Cho HK, Kwon YH
J Nutr Biochem. 2008
PubMed ID: 18430556
The APP670/671 mutation alters calcium signaling and response to hyperosmotic stress in rat primary hippocampal neurons.
Kloskowska E, Bruton JD, Winblad B, Benedikz E
Neurosci Lett. 2008
PubMed ID: 18761056
Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions.
Suzuki T, Nakaya T
J Biol Chem. 2008
PubMed ID: 18650433
Amyloid precursor protein trafficking, processing, and function.
Thinakaran G, Koo EH
J Biol Chem. 2008
PubMed ID: 18650430
The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.
Nakayama K, Ohkawara T, Hiratochi M, Koh CS, Nagase H
Neurosci Lett. 2008
PubMed ID: 18722509
Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis.
Hassen GW, Feliberti J, Kesner L, Stracher A, Mokhtarian F
Brain Res. 2008
PubMed ID: 18725211
Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing.
Sakurai T, Kaneko K, Okuno M, Wada K, Kashiyama T, Shimizu H, Akagi T, Hashikawa T, Nukina N
J Cell Biol. 2008
PubMed ID: 18936252
Genetic association between low-density lipoprotein receptor-related protein gene polymorphisms and Alzheimer's disease in Chinese Han population.
Zhou YT, Zhang ZX, Chan P, He XM, Tang MN, Wu CB, Hong Z
Neurosci Lett. 2008
PubMed ID: 18706476
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Jan A, Gokce O, Luthi-Carter R, Lashuel HA
J Biol Chem. 2008
PubMed ID: 18694930
Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study.
Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, Jones S, Collins A, Stone E, Lotery A
Lancet. 2008
PubMed ID: 18842294
Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels.
Zhang YQ, Sarge KD
Biochem Biophys Res Commun. 2008
PubMed ID: 18675254
Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.
Li H, Koshiba S, Hayashi F, Tochio N, Tomizawa T, Kasai T, Yabuki T, Motoda Y, Harada T, Watanabe S, Inoue M, Hayashizaki Y, Tanaka A, Kigawa T, Yokoyama S
J Biol Chem. 2008
PubMed ID: 18650440
Association between progranulin and beta-amyloid in dementia with Lewy bodies.
Revuelta GJ, Rosso A, Lippa CF
Am J Alzheimers Dis Other Demen. 2008
PubMed ID: 18955727
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Du H, Guo L, Fang F, Chen D, Sosunov AA, McKhann GM, Yan Y, Wang C, Zhang H, Molkentin JD, Gunn-Moore FJ, Vonsattel JP, Arancio O, Chen JX, Yan SD
Nat Med. 2008
PubMed ID: 18806802
Secondary structure conversions of Alzheimer's Abeta(1-40) peptide induced by membrane-mimicking detergents.
Wahlström A, Hugonin L, Perálvarez-Marín A, Jarvet J, Gräslund A
FEBS J. 2008
PubMed ID: 18786140
Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N-methyl-d-aspartate receptor signaling.
Shimazawa M, Inokuchi Y, Okuno T, Nakajima Y, Sakaguchi G, Kato A, Oku H, Sugiyama T, Kudo T, Ikeda T, Takeda M, Hara H
J Neurochem. 2008
PubMed ID: 18691390
Phosphorylated tau in neuritic plaques of APP(sw)/Tau (vlw) transgenic mice and Alzheimer disease.
Pérez M, Morán MA, Ferrer I, Avila J, Gómez-Ramos P
Acta Neuropathol. 2008
PubMed ID: 18679696
The structure of the amyloid-beta peptide high-affinity copper II binding site in Alzheimer disease.
Streltsov VA, Titmuss SJ, Epa VC, Barnham KJ, Masters CL, Varghese JN
Biophys J. 2008
PubMed ID: 18599641
Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptors.
Tokay T, Hachem R, Masmoudi-Kouki O, Gandolfo P, Desrues L, Leprince J, Castel H, Diallo M, Amri M, Vaudry H, Tonon MC
Glia. 2008
PubMed ID: 18512251
The effect of amyloidosis-beta and ageing on proliferation of neuronal progenitor cells in APP-transgenic mouse hippocampus and in culture.
Kolecki R, Lafauci G, Rubenstein R, Mazur-Kolecka B, Kaczmarski W, Frackowiak J
Acta Neuropathol. 2008
PubMed ID: 18483741
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X
Brain Pathol. 2008
PubMed ID: 18422760
Alpha4beta2 nicotinic acetylcholine receptors are required for the amyloid beta protein-induced suppression of long-term potentiation in rat hippocampal CA1 region in vivo.
Wu MN, He YX, Guo F, Qi JS
Brain Res Bull. 2008
PubMed ID: 18602971
Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.
Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM
Neurogenetics. 2008
PubMed ID: 18813964
Cross-strand pairing and amyloid assembly.
Liang Y, Pingali SV, Jogalekar AS, Snyder JP, Thiyagarajan P, Lynn DG
Biochemistry. 2008
PubMed ID: 18759497
Differential regulation of neurogenesis in two neurogenic regions of APPswe/PS1dE9 transgenic mice.
Niidome T, Taniuchi N, Akaike A, Kihara T, Sugimoto H
Neuroreport. 2008
PubMed ID: 18766011
Imaging amyloid deposition in Lewy body diseases.
Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA
Neurology. 2008
PubMed ID: 18794492
Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis.
Kyriazis GA, Wei Z, Vandermey M, Jo DG, Xin O, Mattson MP, Chan SL
J Biol Chem. 2008
PubMed ID: 18599481
Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?
Beel AJ, Mobley CK, Kim HJ, Tian F, Hadziselimovic A, Jap B, Prestegard JH, Sanders CR
Biochemistry. 2008
PubMed ID: 18702528
NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons.
Matrone C, Ciotti MT, Mercanti D, Marolda R, Calissano P
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18728191
Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.
Gakhar-Koppole N, Hundeshagen P, Mandl C, Weyer SW, Allinquant B, Müller U, Ciccolini F
Eur J Neurosci. 2008
PubMed ID: 18717733
Region-specific changes in the microanatomy of single dendritic spines over time might account for selective memory alterations in ageing hAPPsweTg2576 mice, a mouse model for Alzheimer disease.
Middei S, Restivo L, Caprioli A, Aceti M, Ammassari-Teule M
Neurobiol Learn Mem. 2008
PubMed ID: 18515161
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.
Misawa T, Arima K, Mizusawa H, Satoh J
Acta Neuropathol. 2008
PubMed ID: 18509662
Amyloid-beta dynamics correlate with neurological status in the injured human brain.
Brody DL, Magnoni S, Schwetye KE, Spinner ML, Esparza TJ, Stocchetti N, Zipfel GJ, Holtzman DM
Science. 2008
PubMed ID: 18755980
Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Choi SH, Veeraraghavalu K, Lazarov O, Marler S, Ransohoff RM, Ramirez JM, Sisodia SS
Neuron. 2008
PubMed ID: 18760694
The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.
Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, Roach AH, Cantone JL, Ford MJ, Drexler DM, Olson RE, Yang MG, Bergstrom CP, McElhone KE, Bronson JJ, Macor JE, Blat Y, Grafstrom RH, Stern AM, Seiffert DA, Zaczek R, Albright CF, Toyn JH
J Biol Chem. 2008
PubMed ID: 18574238
Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.
Galvan V, Zhang J, Gorostiza OF, Banwait S, Huang W, Ataie M, Tang H, Bredesen DE
Behav Brain Res. 2008
PubMed ID: 18485495
Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo.
Ahn KW, Joo Y, Choi Y, Kim M, Lee SH, Cha SH, Suh YH, Kim HS
J Neurosci Res. 2008
PubMed ID: 18438935
Effects of familial Alzheimer's disease mutations on the folding nucleation of the amyloid beta-protein.
Krone MG, Baumketner A, Bernstein SL, Wyttenbach T, Lazo ND, Teplow DB, Bowers MT, Shea JE
J Mol Biol. 2008
PubMed ID: 18597778
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory.
Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC
Neurobiol Dis. 2008
PubMed ID: 18585048
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ
Nat Med. 2008
PubMed ID: 18568035
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU
Exp Cell Res. 2008
PubMed ID: 18559276
CSF beta-amyloid 1-42 and tau in Tunisian patients with Alzheimer's disease: The effect of APOE varepsilon4 allele.
Smach MA, Charfeddine B, Lammouchi T, Harrabi I, Ben Othman L, Dridi H, Bennamou S, Limem K
Neurosci Lett. 2008
PubMed ID: 18555606
Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.
Schrenk-Siemens K, Perez-Alcala S, Richter J, Lacroix E, Rahuel J, Korte M, Müller U, Barde YA, Bibel M
Stem Cells. 2008
PubMed ID: 18535156
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D
J Endocrinol. 2008
PubMed ID: 18480379
Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress.
Ferrera P, Mercado-Gómez O, Silva-Aguilar M, Valverde M, Arias C
Neurochem Res. 2008
PubMed ID: 18288607
Protein expression of BACE1, BACE2 and APP in Down syndrome brains.
Cheon MS, Dierssen M, Kim SH, Lubec G
Amino Acids. 2008
PubMed ID: 18163181
Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP.
Guerreiro RJ, Baquero M, Blesa R, Boada M, Brás JM, Bullido MJ, Calado A, Crook R, Ferreira C, Frank A, Gómez-Isla T, Hernández I, Lleó A, Machado A, Martínez-Lage P, Masdeu J, Molina-Porcel L, Molinuevo JL, Pastor P, Pérez-Tur J, Relvas R, Oliveira CR, Ribeiro MH, Rogaeva E, Sa A, Samaranch L, Sánchez-Valle R, Santana I, Tàrraga L, Valdivieso F, Singleton A, Hardy J, Clarimón J
Neurobiol Aging. 2008
PubMed ID: 18667258
Amyloid beta-peptide levels in laser capture microdissected cornu ammonis 1 pyramidal neurons of Alzheimer's brain.
Aoki M, Volkmann I, Tjernberg LO, Winblad B, Bogdanovic N
Neuroreport. 2008
PubMed ID: 18596605
Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, Thinakaran G
J Biol Chem. 2008
PubMed ID: 18456655
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.
Nakaya T, Kawai T, Suzuki T
J Biol Chem. 2008
PubMed ID: 18468999
Plasma lipoprotein beta-amyloid in subjects with Alzheimer's disease or mild cognitive impairment.
Mamo JC, Jian L, James AP, Flicker L, Esselmann H, Wiltfang J
Ann Clin Biochem. 2008
PubMed ID: 18583625
Genes contributing to prion pathogenesis.
Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubinstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB
J Gen Virol. 2008
PubMed ID: 18559949
Amyloid precursor protein expression is upregulated in adipocytes in obesity.
Lee YH, Tharp WG, Maple RL, Nair S, Permana PA, Pratley RE
Obesity (Silver Spring). 2008
PubMed ID: 18483477
High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy MS, Bhat NR
J Neurochem. 2008
PubMed ID: 18410513
Increased total-Tau levels in cerebrospinal fluid of pediatric hydrocephalus and brain tumor patients.
de Bont JM, Vanderstichele H, Reddingius RE, Pieters R, van Gool SW
Eur J Paediatr Neurol. 2008
PubMed ID: 17951083
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production.
Green KN, Demuro A, Akbari Y, Hitt BD, Smith IF, Parker I, LaFerla FM
J Cell Biol. 2008
PubMed ID: 18591429
A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.
Dreses-Werringloer U, Lambert JC, Vingtdeux V, Zhao H, Vais H, Siebert A, Jain A, Koppel J, Rovelet-Lecrux A, Hannequin D, Pasquier F, Galimberti D, Scarpini E, Mann D, Lendon C, Campion D, Amouyel P, Davies P, Foskett JK, Campagne F, Marambaud P
Cell. 2008
PubMed ID: 18585350
Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory.
Van Dijck A, Vloeberghs E, Van Dam D, Staufenbiel M, De Deyn PP
Behav Brain Res. 2008
PubMed ID: 18359101
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model.
Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, Saido TC, Klein WL, Duff KE, Aisen PS, Matsuoka Y
Brain Res. 2008
PubMed ID: 18486110
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S
J Biol Chem. 2008
PubMed ID: 18426795
A common beta-sheet architecture underlies in vitro and in vivo beta2-microglobulin amyloid fibrils.
Jahn TR, Tennent GA, Radford SE
J Biol Chem. 2008
PubMed ID: 18424782
The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis.
Llovera RE, de Tullio M, Alonso LG, Leissring MA, Kaufman SB, Roher AE, de Prat Gay G, Morelli L, Castaño EM
J Biol Chem. 2008
PubMed ID: 18411275
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
Dolcini V, Dunys J, Sevalle J, Chen F, Guillot-Sestier MV, St George-Hyslop P, Fraser PE, Checler F
Biochem Biophys Res Commun. 2008
PubMed ID: 18405662
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A
J Biol Chem. 2008
PubMed ID: 18430735
Transglutaminase induces protofibril-like amyloid beta-protein assemblies that are protease-resistant and inhibit long-term potentiation.
Hartley DM, Zhao C, Speier AC, Woodard GA, Li S, Li Z, Walz T
J Biol Chem. 2008
PubMed ID: 18397883
Upregulation of beta-amyloid precursor protein expression in glioblastoma multiforme.
Culicchia F, Cui JG, Li YY, Lukiw WJ
Neuroreport. 2008
PubMed ID: 18521005
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.
Locascio JJ, Fukumoto H, Yap L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC
Arch Neurol. 2008
PubMed ID: 18541797
Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model.
Vloeberghs E, Van Dam D, Franck F, Serroyen J, Geert M, Staufenbiel M, De Deyn PP
Behav Neurosci. 2008
PubMed ID: 18513119
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T
J Clin Invest. 2008
PubMed ID: 18497889
Regulation of Abeta pathology by beclin 1: a protective role for autophagy?
Lee JA, Gao FB
J Clin Invest. 2008
PubMed ID: 18497881
Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis.
Ermini FV, Grathwohl S, Radde R, Yamaguchi M, Staufenbiel M, Palmer TD, Jucker M
Am J Pathol. 2008
PubMed ID: 18467698
Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes.
Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM, Gylys KH
Am J Pathol. 2008
PubMed ID: 18467692
The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production.
Volmar CH, Ait-Ghezala G, Frieling J, Paris D, Mullan MJ
Cytokine. 2008
PubMed ID: 18434187
Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.
Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, Andrikopoulos S, Cappai R
J Pathol. 2008
PubMed ID: 18393365
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S
Neurobiol Dis. 2008
PubMed ID: 18387811
Androgens regulate neprilysin expression: role in reducing beta-amyloid levels.
Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike CJ
J Neurochem. 2008
PubMed ID: 18346198
Impact of cholesterol level upon APP and BACE proximity and APP cleavage.
von Arnim CA, von Einem B, Weber P, Wagner M, Schwanzar D, Spoelgen R, Strauss WL, Schneckenburger H
Biochem Biophys Res Commun. 2008
PubMed ID: 18374657
Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein.
Kerrigan TL, Atkinson L, Peers C, Pearson HA
Neuroreport. 2008
PubMed ID: 18463498
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy.
Sachse C, Fändrich M, Grigorieff N
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18483195
A Novel Sorting Nexin Modulates Endocytic Trafficking and {alpha}-Secretase Cleavage of the Amyloid Precursor Protein.
Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF
J Biol Chem. 2008
PubMed ID: 18353773
Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
Cater MA, McInnes KT, Li QX, Volitakis I, La Fontaine S, Mercer JF, Bush AI
Biochem J. 2008
PubMed ID: 18248325
Atypical early-onset Alzheimer's disease caused by the Iranian APP mutation.
Lindquist SG, Nielsen JE, Stokholm J, Schwartz M, Batbayli M, Ballegaard M, Erdal J, Krabbe K, Waldemar G
J Neurol Sci. 2008
PubMed ID: 18187157
APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.
Kloskowska E, Malkiewicz K, Winblad B, Benedikz E, Bruton JD
Neurosci Lett. 2008
PubMed ID: 18403114
FDG autoradiography reveals developmental and pathological effects of mutant amyloid in PDAPP transgenic mice.
Valla J, Gonzalez-Lima F, Reiman EM
Int J Dev Neurosci. 2008
PubMed ID: 18358666
Abeta-globulomers are formed independently of the fibril pathway.
Gellermann GP, Byrnes H, Striebinger A, Ullrich K, Mueller R, Hillen H, Barghorn S
Neurobiol Dis. 2008
PubMed ID: 18353662
Modulation of synaptic plasticity and Tau phosphorylation by wild-type and mutant presenilin1.
Dewachter I, Ris L, Croes S, Borghgraef P, Devijver H, Voets T, Nilius B, Godaux E, Van Leuven F
Neurobiol Aging. 2008
PubMed ID: 17222948
Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes.
Lee J, Retamal C, Cuitiño L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G
J Biol Chem. 2008
PubMed ID: 18276590
Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15-28 fragment of the Alzheimer amyloid-beta protein.
Baumketner A, Krone MG, Shea JE
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18408165
A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.
Sompol P, Ittarat W, Tangpong J, Chen Y, Doubinskaia I, Batinic-Haberle I, Abdul HM, Butterfield DA, St Clair DK
Neuroscience. 2008
PubMed ID: 18353561
Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides.
Minicozzi V, Stellato F, Comai M, Serra MD, Potrich C, Meyer-Klaucke W, Morante S
J Biol Chem. 2008
PubMed ID: 18234670
NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
Buggia-Prevot V, Sevalle J, Rossner S, Checler F
J Biol Chem. 2008
PubMed ID: 18263584
Beta-amyloid(1-42) induces neuronal death through the p75 neurotrophin receptor.
Sotthibundhu A, Sykes AM, Fox B, Underwood CK, Thangnipon W, Coulson EJ
J Neurosci. 2008
PubMed ID: 18400893
PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients.
Belbin O, Beaumont H, Warden D, Smith AD, Kalsheker N, Morgan K
Neurobiol Aging. 2008
PubMed ID: 18403054
Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product.
Liu L, Komatsu H, Murray IV, Axelsen PH
J Mol Biol. 2008
PubMed ID: 18304576
Identification of PSEN1 and APP gene mutations in Korean patients with early-onset Alzheimer's disease.
Park HK, Na DL, Lee JH, Kim JW, Ki CS
J Korean Med Sci. 2008
PubMed ID: 18437002
Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
Remes AM, Laru L, Tuominen H, Aalto S, Kemppainen N, Mononen H, Någren K, Parkkola R, Rinne JO
Arch Neurol. 2008
PubMed ID: 18413480
Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
Basun H, Bogdanovic N, Ingelsson M, Almkvist O, Näslund J, Axelman K, Bird TD, Nochlin D, Schellenberg GD, Wahlund LO, Lannfelt L
Arch Neurol. 2008
PubMed ID: 18413473
Aluminium exposure induces Alzheimer's disease-like histopathological alterations in mouse brain.
Rodella LF, Ricci F, Borsani E, Stacchiotti A, Foglio E, Favero G, Rezzani R, Mariani C, Bianchi R
Histol Histopathol. 2008
PubMed ID: 18228200
Inhibitory effects of short-term administration of DL-alpha-lipoic acid on oxidative vulnerability induced by Abeta amyloid fibrils (25-35) in mice.
Jesudason EP, Masilamoni JG, Ashok BS, Baben B, Arul V, Jesudoss KS, Jebaraj WC, Dhandayuthapani S, Vignesh S, Jayakumar R
Mol Cell Biochem. 2008
PubMed ID: 18224425
Amyloid precursor protein cytoplasmic domain antagonizes reelin neurite outgrowth inhibition of hippocampal neurons.
Hoareau C, Borrell V, Soriano E, Krebs MO, Prochiantz A, Allinquant B
Neurobiol Aging. 2008
PubMed ID: 17169463
Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease.
Pistell PJ, Zhu M, Ingram DK
Neuroscience. 2008
PubMed ID: 18304749
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
Kienlen-Campard P, Tasiaux B, Van Hees J, Li M, Huysseune S, Sato T, Fei JZ, Aimoto S, Courtoy PJ, Smith SO, Constantinescu SN, Octave JN
J Biol Chem. 2008
PubMed ID: 18201969
Protofibril assemblies of the arctic, Dutch, and Flemish mutants of the Alzheimer's Abeta1-40 peptide.
Fawzi NL, Kohlstedt KL, Okabe Y, Head-Gordon T
Biophys J. 2008
PubMed ID: 18032553
Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP.
Kaden D, Munter LM, Joshi M, Treiber C, Weise C, Bethge T, Voigt P, Schaefer M, Beyermann M, Reif B, Multhaup G
J Biol Chem. 2008
PubMed ID: 18182389
Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis.
Sodhi CP, Perez RG, Gottardi-Littell NR
Brain Res. 2008
PubMed ID: 18275940
Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
Hoe HS, Minami SS, Makarova A, Lee J, Hyman BT, Matsuoka Y, Rebeck GW
J Biol Chem. 2008
PubMed ID: 18089558
Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease.
Van Vickle GD, Esh CL, Kokjohn TA, Patton RL, Kalback WM, Luehrs DC, Beach TG, Newel AJ, Lopera F, Ghetti B, Vidal R, Castaño EM, Roher AE
Mol Med. 2008
PubMed ID: 18317569
A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia.
Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H
Ann Neurol. 2008
PubMed ID: 18300294
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.
Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC
Nat Cell Biol. 2008
PubMed ID: 18278038
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system.
Osterfield M, Egelund R, Young LM, Flanagan JG
Development. 2008
PubMed ID: 18272596
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease.
Van Dam D, Coen K, De Deyn PP
Psychopharmacology (Berl). 2008
PubMed ID: 18008065
Beta2-microglobulin amyloid fragment organization and morphology and its comparison to Abeta suggests that amyloid aggregation pathways are sequence specific.
Zheng J, Jang H, Nussinov R
Biochemistry. 2008
PubMed ID: 18215070
Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8.
Lee MR, Lee D, Shin SK, Kim YH, Choi CY
Biochem Biophys Res Commun. 2008
PubMed ID: 18096514
Molecular dynamics study to investigate the effect of chemical substitutions of methionine 35 on the secondary structure of the amyloid beta (Abeta(1-42)) monomer in aqueous solution.
Triguero L, Singh R, Prabhakar R
J Phys Chem B. 2008
PubMed ID: 18220385
Membrane fusogenic activity of the Alzheimer's peptide A beta(1-42) demonstrated by small-angle neutron scattering.
Dante S, Hauss T, Brandt A, Dencher NA
J Mol Biol. 2008
PubMed ID: 18164313
Cellular localization of Nicastrin affects amyloid beta species production.
Morais VA, Leight S, Pijak DS, Lee VM, Costa J
FEBS Lett. 2008
PubMed ID: 18201567
Expression of amyloid beta peptide in human platelets: pivotal role of the phospholipase Cgamma2-protein kinase C pathway in platelet activation.
Shen MY, Hsiao G, Fong TH, Chou DS, Sheu JR
Pharmacol Res. 2008
PubMed ID: 18313326
Plasma beta amyloid and cytokine profile in women with Alzheimer's disease.
Baranowska-Bik A, Bik W, Wolinska-Witort E, Martynska L, Chmielowska M, Barcikowska M, Baranowska B
Neuro Endocrinol Lett. 2008
PubMed ID: 18283248
Development of homogeneous 384-well high-throughput screening assays for Abeta1-40 and Abeta1-42 using AlphaScreen technology.
Szekeres PG, Leong K, Day TA, Kingston AE, Karran EH
J Biomol Screen. 2008
PubMed ID: 18216395
One-year longitudinal evaluation of sensorimotor functions in APP751SL transgenic mice.
Le Cudennec C, Faure A, Ly M, Delatour B
Genes Brain Behav. 2008
PubMed ID: 18184372
Low prevalence of APP duplications in Swedish and Finnish patients with early-onset Alzheimer's disease.
Blom ES, Viswanathan J, Kilander L, Helisalmi S, Soininen H, Lannfelt L, Ingelsson M, Glaser A, Hiltunen M
Eur J Hum Genet. 2008
PubMed ID: 18043715
Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease.
Lv H, Jia L, Jia J
Neurobiol Aging. 2008
PubMed ID: 17112637
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
Van Broeck B, Vanhoutte G, Pirici D, Van Dam D, Wils H, Cuijt I, Vennekens K, Zabielski M, Michalik A, Theuns J, De Deyn PP, Van der Linden A, Van Broeckhoven C, Kumar-Singh S
Neurobiol Aging. 2008
PubMed ID: 17112635
Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.
Nimmrich V, Grimm C, Draguhn A, Barghorn S, Lehmann A, Schoemaker H, Hillen H, Gross G, Ebert U, Bruehl C
J Neurosci. 2008
PubMed ID: 18216187
Exclusion of the native alpha-helix from the amyloid fibrils of a mixed alpha/beta protein.
Morgan GJ, Giannini S, Hounslow AM, Craven CJ, Zerovnik E, Turk V, Waltho JP, Staniforth RA
J Mol Biol. 2008
PubMed ID: 18021806
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid.
Holback S, Adlerz L, Gatsinzi T, Jacobsen KT, Iverfeldt K
Biochem Biophys Res Commun. 2008
PubMed ID: 17986385
Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning.
Senechal Y, Kelly PH, Dev KK
Behav Brain Res. 2008
PubMed ID: 17884188
Stepwise dynamics of epitaxially growing single amyloid fibrils.
Kellermayer MS, Karsai A, Benke M, Soós K, Penke B
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18162558
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC Genomics. 2008
PubMed ID: 18973680
Abeta mediated diminution of MTT reduction--an artefact of single cell culture?
Rönicke R, Klemm A, Meinhardt J, Schröder UH, Fändrich M, Reymann KG
PLoS ONE. 2008
PubMed ID: 18800168
Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.
Xu G, Karch C, Li N, Lin N, Fromholt D, Gonzales V, Borchelt DR
PLoS ONE. 2008
PubMed ID: 18776935
The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome.
Jones EL, Margallo-Lana M, Prasher VP, Ballard CG
Dement Geriatr Cogn Disord. 2008
PubMed ID: 18765933
Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation.
Lee JW, Lee YK, Yuk DY, Choi DY, Ban SB, Oh KW, Hong JT
J Neuroinflammation. 2008
PubMed ID: 18759972
Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.
Sanz-Blasco S, Valero RA, Rodríguez-Crespo I, Villalobos C, Núñez L
PLoS ONE. 2008
PubMed ID: 18648507
Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.
Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ
Neural Dev. 2008
PubMed ID: 18573216
Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors.
Pla P, Hirsch MR, Le Crom S, Reiprich S, Harley VR, Goridis C
Neural Dev. 2008
PubMed ID: 18565209
Cube copying test in combination with rCBF or CSF A beta 42 predicts development of Alzheimer's disease.
Buchhave P, Stomrud E, Warkentin S, Blennow K, Minthon L, Hansson O
Dement Geriatr Cogn Disord. 2008
PubMed ID: 18535375
Increased prevalence of significant recurrent headache in preclinical familial Alzheimer's disease mutation carriers.
Ringman JM, Romano JD, Medina LD, Rodriguez-Agudelo Y, Schaffer B, Varpetian A, Ortiz F, Fitten LJ, Cummings JL, Baloh RW
Dement Geriatr Cogn Disord. 2008
PubMed ID: 18376127
Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease.
Debatin L, Streffer J, Geissen M, Matschke J, Aguzzi A, Glatzel M
Neurodegener Dis. 2008
PubMed ID: 18349519
Mechanism of glial differentiation of neural progenitor cells by amyloid precursor protein.
Sugaya K
Neurodegener Dis. 2008
PubMed ID: 18322381
Soluble beta-amyloid leads to mitochondrial defects in amyloid precursor protein and tau transgenic mice.
Eckert A, Hauptmann S, Scherping I, Rhein V, Müller-Spahn F, Götz J, Müller WE
Neurodegener Dis. 2008
PubMed ID: 18322377
Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway.
Dinamarca MC, Colombres M, Cerpa W, Bonansco C, Inestrosa NC
Neurodegener Dis. 2008
PubMed ID: 18322375
Intraneuronal beta-amyloid is a major risk factor--novel evidence from the APP/PS1KI mouse model.
Bayer TA, Breyhan H, Duan K, Rettig J, Wirths O
Neurodegener Dis. 2008
PubMed ID: 18322372
Prediction of Alzheimer's disease using a cerebrospinal fluid pattern of C-terminally truncated beta-amyloid peptides.
Höglund K, Hansson O, Buchhave P, Zetterberg H, Lewczuk P, Londos E, Blennow K, Minthon L, Wiltfang J
Neurodegener Dis. 2008
PubMed ID: 18309230
Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila.
Iijima K, Chiang HC, Hearn SA, Hakker I, Gatt A, Shenton C, Granger L, Leung A, Iijima-Ando K, Zhong Y
PLoS ONE. 2008
PubMed ID: 18301778
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants.
Gorman PM, Kim S, Guo M, Melnyk RA, McLaurin J, Fraser PE, Bowie JU, Chakrabartty A
BMC Neurosci. 2008
PubMed ID: 18234110
A genetic interaction between the APP and Dab1 genes influences brain development.
Pramatarova A, Chen K, Howell BW
Mol Cell Neurosci. 2008
PubMed ID: 18029196
Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice.
Frye CA, Walf AA
Neurobiol Learn Mem. 2008
PubMed ID: 17988898
Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network.
Shrivastava-Ranjan P, Faundez V, Fang G, Rees H, Lah JJ, Levey AI, Kahn RA
Mol Biol Cell. 2008
PubMed ID: 17959829
Abeta deposition and related pathology in an APP x PS1 transgenic mouse model of Alzheimer's disease.
Howlett DR, Bowler K, Soden PE, Riddell D, Davis JB, Richardson JC, Burbidge SA, Gonzalez MI, Irving EA, Lawman A, Miglio G, Dawson EL, Howlett ER, Hussain I
Histol Histopathol. 2008
PubMed ID: 17952859
The in vivo brain interactome of the amyloid precursor protein.
Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G
Mol Cell Proteomics. 2008
PubMed ID: 17934213
A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference.
Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ
J Neurosci. 2007
PubMed ID: 18160654
The binding constant for amyloid Abeta40 peptide interaction with human serum albumin.
Rózga M, Kłoniecki M, Jabłonowska A, Dadlez M, Bal W
Biochem Biophys Res Commun. 2007
PubMed ID: 18028874
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
The cell-selective neurotoxicity of the Alzheimer's Abeta peptide is determined by surface phosphatidylserine and cytosolic ATP levels. Membrane binding is required for Abeta toxicity.
Simakova O, Arispe NJ
J Neurosci. 2007
PubMed ID: 18077683
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA
Neuroscience. 2007
PubMed ID: 17945434
Reduction of mint-1, mint-2, and APP overexpression in okadaic acid-treated neurons.
Yoon S, Choi J, Haam J, Choe H, Kim D
Neuroreport. 2007
PubMed ID: 18007179
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.
Chimon S, Shaibat MA, Jones CR, Calero DC, Aizezi B, Ishii Y
Nat Struct Mol Biol. 2007
PubMed ID: 18059284
Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells.
Wilhelmus MM, Otte-Höller I, van Triel JJ, Veerhuis R, Maat-Schieman ML, Bu G, de Waal RM, Verbeek MM
Am J Pathol. 2007
PubMed ID: 18055545
Cystatin C modulates cerebral beta-amyloidosis.
Kaeser SA, Herzig MC, Coomaraswamy J, Kilger E, Selenica ML, Winkler DT, Staufenbiel M, Levy E, Grubb A, Jucker M
Nat Genet. 2007
PubMed ID: 18026102
Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.
Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E
Nat Genet. 2007
PubMed ID: 18026100
Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.
Chafekar SM, Hoozemans JJ, Zwart R, Baas F, Scheper W
Antioxid Redox Signal. 2007
PubMed ID: 17979527
Rat's trick to escape Alzheimer's disease.
Shen L, Ji HF
J Biomol Struct Dyn. 2007
PubMed ID: 17937488
Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice.
Aoki C, Mahadomrongkul V, Fujisawa S, Habersat R, Shirao T
J Comp Neurol. 2007
PubMed ID: 17912741
Abeta(1-40)-induced secretion of matrix metalloproteinase-9 results in sAPPalpha release by association with cell surface APP.
Talamagas AA, Efthimiopoulos S, Tsilibary EC, Figueiredo-Pereira ME, Tzinia AK
Neurobiol Dis. 2007
PubMed ID: 17761425
Amyloid beta-protein precursor juxtamembrane domain regulates specificity of gamma-secretase-dependent cleavages.
Ren Z, Schenk D, Basi GS, Shapiro IP
J Biol Chem. 2007
PubMed ID: 17890228
Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses.
Yang L, Wang B, Long C, Wu G, Zheng H
Neuroscience. 2007
PubMed ID: 17919826
Amyloid beta deposition is related to decreased glucose transporter-1 levels and hippocampal atrophy in brains of aged APP/PS1 mice.
Hooijmans CR, Graven C, Dederen PJ, Tanila H, van Groen T, Kiliaan AJ
Brain Res. 2007
PubMed ID: 17916337
Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
Wiley JC, Smith EA, Hudson MP, Ladiges WC, Bothwell M
J Biol Chem. 2007
PubMed ID: 17855370
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway.
Townsend M, Mehta T, Selkoe DJ
J Biol Chem. 2007
PubMed ID: 17855343
Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils.
Klement K, Wieligmann K, Meinhardt J, Hortschansky P, Richter W, Fändrich M
J Mol Biol. 2007
PubMed ID: 17905305
Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo.
Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T
J Biol Chem. 2007
PubMed ID: 17767011
Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron.
Nakamura M, Shishido N, Nunomura A, Smith MA, Perry G, Hayashi Y, Nakayama K, Hayashi T
Biochemistry. 2007
PubMed ID: 17929832
Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism.
Zhang YW, Xu H
Curr Mol Med. 2007
PubMed ID: 18045146
Pathogenic role of mitochondrial [correction of mitochondral] amyloid-beta peptide.
Chen JX, Yan SD
Expert Rev Neurother. 2007
PubMed ID: 17997700
Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease.
Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM
J Clin Invest. 2007
PubMed ID: 17965777
Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.
Mameza MG, Lockard JM, Zamora E, Hillefors M, Lavina ZS, Kaplan BB
J Neurochem. 2007
PubMed ID: 17727637
Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans.
Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD
Autophagy. 2007
PubMed ID: 17675890
Downregulation of myosin II-B by siRNA alters the subcellular localization of the amyloid precursor protein and increases amyloid-beta deposition in N2a cells.
Massone S, Argellati F, Passalacqua M, Armirotti A, Melone L, d'Abramo C, Marinari UM, Domenicotti C, Pronzato MA, Ricciarelli R
Biochem Biophys Res Commun. 2007
PubMed ID: 17727819
Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.
Grant MA, Lazo ND, Lomakin A, Condron MM, Arai H, Yamin G, Rigby AC, Teplow DB
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17940047
Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.
Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G
Neuron. 2007
PubMed ID: 17920016
Molecular basis for passive immunotherapy of Alzheimer's disease.
Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17895381
Abeta40 is associated with cognitive function, body fat and physical fitness in healthy older adults.
Leahey TM, Myers TA, Gunstad J, Glickman E, Spitznagel MB, Alexander T, Juvancic-Heltzel J
Nutr Neurosci. 2007
PubMed ID: 18284028
Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Kong GK, Adams JJ, Cappai R, Parker MW
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007
PubMed ID: 17909280
Beta-amyloid (Abeta40, Abeta42) binding to modified LDL accelerates macrophage foam cell formation.
Schulz B, Liebisch G, Grandl M, Werner T, Barlage S, Schmitz G
Biochim Biophys Acta. 2007
PubMed ID: 17881287
AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma.
Provenzano MJ, Yu L, Hitchler MJ, Fitzgerald MP, Robinson RA, Wayne S, Ver Meer M, Domann FE
Exp Mol Pathol. 2007
PubMed ID: 17651731
The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration.
Muresan Z, Muresan V
Mol Biol Cell. 2007
PubMed ID: 17634293
APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage.
Rovelet-Lecrux A, Frebourg T, Tuominen H, Majamaa K, Campion D, Remes AM
J Neurol Neurosurg Psychiatry. 2007
PubMed ID: 17442758
HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation.
Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM
J Biol Chem. 2007
PubMed ID: 17684015
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.
Huysseune S, Kienlen-Campard P, Octave JN
Biochem Biophys Res Commun. 2007
PubMed ID: 17651693
Enhancing Th2 immune responses against amyloid protein by a DNA prime-adenovirus boost regimen for Alzheimer's disease.
Kim HD, Jin JJ, Maxwell JA, Fukuchi K
Immunol Lett. 2007
PubMed ID: 17686533
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Van Vickle GD, Esh CL, Kalback WM, Patton RL, Luehrs DC, Kokjohn TA, Fifield FG, Fraser PE, Westaway D, McLaurin J, Lopez J, Brune D, Newel AJ, Poston M, Beach TG, Roher AE
Biochemistry. 2007
PubMed ID: 17705508
Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.
Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L
Neuron. 2007
PubMed ID: 17785178
[Evaluation of amyloid-beta by the E280A mutation in presenilin gene]
Villegas A, Castañeda MM, Arias LF, Vieco B, Lopera F, Bedoya G
Biomedica. 2007
PubMed ID: 18320103
Effects of beta-amyloid peptide and estrogen on platelet mitochondrial function of Sprague-Dawley rats.
Xu J, Shi C, Li Q, Lam WP, Wai MS, Yew DT
Platelets. 2007
PubMed ID: 17763155
Severe amyloid deposition in mammary glands of familial amyloid polyneuropathy patients.
Tokuda T, Takei Y, Takayama B, Hoshii Y, Ikeda S
Amyloid. 2007
PubMed ID: 17701472
Clearance of amyloid-beta by circulating lipoprotein receptors.
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV
Nat Med. 2007
PubMed ID: 17694066
Increased severity of hemorrhage in transgenic mice expressing cerebral protease nexin-2/amyloid beta-protein precursor.
Xu F, Previti ML, Van Nostrand WE
Stroke. 2007
PubMed ID: 17656662
Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice.
Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, Keller JN
Neurobiol Dis. 2007
PubMed ID: 17651976
Advancing age produces sex differences in vasomotor kinetics during and after skeletal muscle contraction.
Bearden SE
Am J Physiol Regul Integr Comp Physiol. 2007
PubMed ID: 17626125
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
Senechal Y, Kelly PH, Cryan JF, Natt F, Dev KK
J Neurochem. 2007
PubMed ID: 17540010
Amyloid-beta-peptide reduces the expression level of mitochondrial cytochrome oxidase subunits.
Hong WK, Han EH, Kim DG, Ahn JY, Park JS, Han BG
Neurochem Res. 2007
PubMed ID: 17514422
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.
Wang B, Yang L, Wang Z, Zheng H
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17709753
Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.
He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y
J Cell Biol. 2007
PubMed ID: 17724122
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S
J Biol Chem. 2007
PubMed ID: 17573346
Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells.
Kraus B, Wolff H, Heilmann J, Elstner EF
Life Sci. 2007
PubMed ID: 17725929
Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L
J Biol Chem. 2007
PubMed ID: 17548355
Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents.
Turner PR, Bourne K, Garama D, Carne A, Abraham WC, Tate WP
J Neurosci Methods. 2007
PubMed ID: 17537517
Redox reactions of copper complexes formed with different beta-amyloid peptides and their neuropathological [correction of neuropathalogical] relevance.
Jiang D, Men L, Wang J, Zhang Y, Chickenyen S, Wang Y, Zhou F
Biochemistry. 2007
PubMed ID: 17636872
{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.
Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM
J Biol Chem. 2007
PubMed ID: 17556361
Effects of Alzheimer's disease on different cortical layers: the role of intrinsic differences in Abeta susceptibility.
Romito-DiGiacomo RR, Menegay H, Cicero SA, Herrup K
J Neurosci. 2007
PubMed ID: 17687027
Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length.
Lundin C, Johansson S, Johnson AE, Näslund J, von Heijne G, Nilsson I
FEBS Lett. 2007
PubMed ID: 17659280
Effects of wild-type and mutant human amyloid precursor protein on cortical afferent network.
Alpár A, Ueberham U, Seeger G, Arendt T, Gärtner U
Neuroreport. 2007
PubMed ID: 17632276
Upregulation of amyloid precursor protein by platelet-derived growth factor in hippocampal precursor cells.
Lim JS, Cho H, Hong HS, Kwon H, Mook-Jung I, Kwon YK
Neuroreport. 2007
PubMed ID: 17632272
Expression of APP pathway mRNAs and proteins in Alzheimer's disease.
Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT
Brain Res. 2007
PubMed ID: 17586478
Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice.
Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR
J Biol Chem. 2007
PubMed ID: 17556372
Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers.
Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG
J Biol Chem. 2007
PubMed ID: 17545160
Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo.
Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME
J Neurochem. 2007
PubMed ID: 17630980
Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization.
Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe CG
Biochemistry. 2007
PubMed ID: 17595112
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.
Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Müller UC
J Neurosci. 2007
PubMed ID: 17634375
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis.
Laifenfeld D, Patzek LJ, McPhie DL, Chen Y, Levites Y, Cataldo AM, Neve RL
J Neurosci. 2007
PubMed ID: 17611268
Studies on brain volume, Alzheimer-related proteins and cytokines in mice with chronic overexpression of IL-1 receptor antagonist.
Oprica M, Hjorth E, Spulber S, Popescu BO, Ankarcrona M, Winblad B, Schultzberg M
J Cell Mol Med. 2007
PubMed ID: 17760842
Time resolved structure analysis of growing beta-amyloid fibers.
Witte T, Haller LA, Luttmann E, Krüger J, Fels G, Huber K
J Struct Biol. 2007
PubMed ID: 17446087
Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias.
Bibl M, Mollenhauer B, Lewczuk P, Esselmann H, Wolf S, Trenkwalder C, Otto M, Stiens G, Rüther E, Kornhuber J, Wiltfang J
Mol Psychiatry. 2007
PubMed ID: 17339876
Tauopathies and synucleinopathies: do cerebrospinal fluid beta-amyloid peptides reflect disease-specific pathogenesis?
Mollenhauer B, Bibl M, Esselmann H, Steinacker P, Trenkwalder C, Wiltfang J, Otto M
J Neural Transm. 2007
PubMed ID: 17318305
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17573534
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Vingtdeux V, Hamdane M, Loyens A, Gelé P, Drobeck H, Bégard S, Galas MC, Delacourte A, Beauvillain JC, Buée L, Sergeant N
J Biol Chem. 2007
PubMed ID: 17468104
Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.
Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17556541
Abeta40 protects non-toxic Abeta42 monomer from aggregation.
Yan Y, Wang C
J Mol Biol. 2007
PubMed ID: 17481654
Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP).
Nowotny P, Simcock X, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Smemo S, Morris JC, Goate A
Am J Med Genet B Neuropsychiatr Genet. 2007
PubMed ID: 17427190
Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice.
Yamamoto M, Kiyota T, Walsh SM, Ikezu T
J Neuroimmune Pharmacol. 2007
PubMed ID: 18040846
Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction.
Kim SY, Kim MY, Mo JS, Park HS
Biochim Biophys Acta. 2007
PubMed ID: 17368826
Apoptosis signal-regulating kinase 1 in amyloid beta peptide-induced cerebral endothelial cell apoptosis.
Hsu MJ, Hsu CY, Chen BC, Chen MC, Ou G, Lin CH
J Neurosci. 2007
PubMed ID: 17522316
A mutation screening by DHPLC of PSEN1 and APP genes reveals no significant variation associated with the sporadic late-onset form of Alzheimer's disease.
Scacchi R, Gambina G, Moretto G, Corbo RM
Neurosci Lett. 2007
PubMed ID: 17412506
Swedish amyloid precursor protein mutation increases phosphorylation of eIF2alpha in vitro and in vivo.
Kim HS, Choi Y, Shin KY, Joo Y, Lee YK, Jung SY, Suh YH, Kim JH
J Neurosci Res. 2007
PubMed ID: 17393484
The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase.
Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN
J Neurochem. 2007
PubMed ID: 17448150
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching.
Ikin AF, Sabo SL, Lanier LM, Buxbaum JD
Mol Cell Neurosci. 2007
PubMed ID: 17383198
Plasma beta amyloid and impaired CO2-induced cerebral vasomotor reactivity.
van Dijk EJ, Prins ND, Hofman A, van Duijn CM, Koudstaal PJ, Breteler MM
Neurobiol Aging. 2007
PubMed ID: 16698128
Proteins that bind to the RERMS region of beta amyloid precursor protein.
Pawlik M, Otero DA, Park M, Fischer WH, Levy E, Saitoh T
Biochem Biophys Res Commun. 2007
PubMed ID: 17335780
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.
Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF
J Biol Chem. 2007
PubMed ID: 17307738
Increased KPI containing amyloid precursor protein in experimental autoimmune encephalomyelitis brains.
Beilin O, Karussis DM, Korczyn AD, Gurwitz D, Aronovich R, Mizrachi-Kol R, Chapman J
Neuroreport. 2007
PubMed ID: 17413661
The effect of intrahippocampal beta amyloid (1-42) peptide injection on oxidant and antioxidant status in rat brain.
Cetin F, Dincer S
Ann N Y Acad Sci. 2007
PubMed ID: 17460216
Nitric oxide synthase inhibitors modulate nerve growth factor-mediated regulation of amyloid precursor protein expression in PC12 cells.
Binnington JC, Kalisch BE
J Neurochem. 2007
PubMed ID: 17402971
CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.
Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW
Hum Mol Genet. 2007
PubMed ID: 17317785
Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.
Hirsch-Reinshagen V, Chan JY, Wilkinson A, Tanaka T, Fan J, Ou G, Maia LF, Singaraja RR, Hayden MR, Wellington CL
J Lipid Res. 2007
PubMed ID: 17235115
Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease.
Caltagarone J, Jing Z, Bowser R
Biochim Biophys Acta. 2007
PubMed ID: 17215111
Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis.
Neve RL, McPhie DL
Biochim Biophys Acta. 2007
PubMed ID: 17113271
Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins.
Murray IV, Liu L, Komatsu H, Uryu K, Xiao G, Lawson JA, Axelsen PH
J Biol Chem. 2007
PubMed ID: 17255094
Flow-induced alignment of amyloid protofilaments revealed by linear dichroism.
Adachi R, Yamaguchi K, Yagi H, Sakurai K, Naiki H, Goto Y
J Biol Chem. 2007
PubMed ID: 17264078
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, Kobayashi H, Ishikawa HO, Ohsugi Y, Yamamoto T, Matsuno K, Kinjo M, Suzuki T
EMBO J. 2007
PubMed ID: 17332754
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42.
Munter LM, Voigt P, Harmeier A, Kaden D, Gottschalk KE, Weise C, Pipkorn R, Schaefer M, Langosch D, Multhaup G
EMBO J. 2007
PubMed ID: 17332749
The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Abeta peptides.
Liao MQ, Tzeng YJ, Chang LY, Huang HB, Lin TH, Chyan CL, Chen YC
FEBS Lett. 2007
PubMed ID: 17328898
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW
J Mol Biol. 2007
PubMed ID: 17239395
Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.
Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T
Biochem J. 2007
PubMed ID: 17132139
Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice.
Park KH, Hallows JL, Chakrabarty P, Davies P, Vincent I
J Neurosci. 2007
PubMed ID: 17360920
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL
J Neurosci. 2007
PubMed ID: 17360908
Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.
Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L
J Neurosci. 2007
PubMed ID: 17360894
Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease.
Pugh PL, Richardson JC, Bate ST, Upton N, Sunter D
Behav Brain Res. 2007
PubMed ID: 17229472
Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I.
Flajolet M, He G, Heiman M, Lin A, Nairn AC, Greengard P
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360493
Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B.
Icking A, Amaddii M, Ruonala M, Höning S, Tikkanen R
Traffic. 2007
PubMed ID: 17319802
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.
Vingtdeux V, Hamdane M, Bégard S, Loyens A, Delacourte A, Beauvillain JC, Buée L, Marambaud P, Sergeant N
Neurobiol Dis. 2007
PubMed ID: 17207630
Long-lasting impairment in hippocampal neurogenesis associated with amyloid deposition in a knock-in mouse model of familial Alzheimer's disease.
Zhang C, McNeil E, Dressler L, Siman R
Exp Neurol. 2007
PubMed ID: 17070803
Variations in the APP gene promoter region and risk of Alzheimer disease.
Guyant-Maréchal L, Rovelet-Lecrux A, Goumidi L, Cousin E, Hannequin D, Raux G, Penet C, Ricard S, Macé S, Amouyel P, Deleuze JF, Frebourg T, Brice A, Lambert JC, Campion D
Neurology. 2007
PubMed ID: 17325276
Molecular dynamics studies of hexamers of amyloid-beta peptide (16-35) and its mutants: influence of charge states on amyloid formation.
Han W, Wu YD
Proteins. 2007
PubMed ID: 17115426
Electrophysiological and cerebrovascular effects of the alpha-secretase-derived form of amyloid precursor protein in young and middle-aged rats.
Sánchez-Alavez M, Chan SL, Mattson MP, Criado JR
Brain Res. 2007
PubMed ID: 17157827
Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrils.
Fändrich M
J Mol Biol. 2007
PubMed ID: 17141269
When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease.
Wolfe MS
EMBO Rep. 2007
PubMed ID: 17268504
Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.
Reiserer RS, Harrison FE, Syverud DC, McDonald MP
Genes Brain Behav. 2007
PubMed ID: 17233641
Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65.
Bao J, Cao C, Zhang X, Jiang F, Nicosia SV, Bai W
Mol Cell Biol. 2007
PubMed ID: 17130235
The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion.
Copanaki E, Schürmann T, Eckert A, Leuner K, Müller WE, Prehn JH, Kögel D
Biochim Biophys Acta. 2007
PubMed ID: 17113167
Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.
Biswas SC, Shi Y, Vonsattel JP, Leung CL, Troy CM, Greene LA
J Neurosci. 2007
PubMed ID: 17251431
Abeta40 inhibits amyloid deposition in vivo.
Kim J, Onstead L, Randle S, Price R, Smithson L, Zwizinski C, Dickson DW, Golde T, McGowan E
J Neurosci. 2007
PubMed ID: 17234594
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage.
Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
J Biol Chem. 2007
PubMed ID: 17121854
Beta 2-microglobulin amyloid deposit in HLA-B27 transgenic rats.
Fukunishi S, Yoh K, Kamae S, Yoshiya S
Mod Rheumatol. 2007
PubMed ID: 17929129
Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome.
Englund H, Annerén G, Gustafsson J, Wester U, Wiltfang J, Lannfelt L, Blennow K, Höglund K
Dement Geriatr Cogn Disord. 2007
PubMed ID: 17914261
Germ line origin and somatic mutations determine the target tissues in systemic AL-amyloidosis.
Enqvist S, Sletten K, Stevens FJ, Hellman U, Westermark P
PLoS ONE. 2007
PubMed ID: 17912358
Tyr687 dependent APP endocytosis and Abeta production.
Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA
J Mol Neurosci. 2007
PubMed ID: 17873282
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice.
Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM
BMC Neurosci. 2007
PubMed ID: 17650315
A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ
BMC Genet. 2007
PubMed ID: 17601350
Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.
Rakover I, Arbel M, Solomon B
Neurodegener Dis. 2007
PubMed ID: 17536186
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage.
Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP, LaFerla FM, Gozes I, Aisen PS
J Mol Neurosci. 2007
PubMed ID: 17478890
Localizations of endogenous APP/APP-proteolytic products are consistent with microtubular transport.
Zitnik G, Wang L, Martin GM, Hu Q
J Mol Neurosci. 2007
PubMed ID: 17416970
Amyloid precursor protein and Presenilin 1 interaction studied by FRET in human H4 cells.
Nizzari M, Venezia V, Bianchini P, Caorsi V, Diaspro A, Repetto E, Thellung S, Corsaro A, Carlo P, Schettini G, Florio T, Russo C
Ann N Y Acad Sci. 2007
PubMed ID: 17405936
Differential distribution of Alzheimer's amyloid precursor protein family variants in human sperm.
Fardilha M, Vieira SI, Barros A, Sousa M, Da Cruz e Silva OA, Da Cruz e Silva EF
Ann N Y Acad Sci. 2007
PubMed ID: 17405931
Altered subcellular distribution of the Alzheimer's amyloid precursor protein under stress conditions.
Domingues SC, Henriques AG, Wu W, Da Cruz e Silva EF, Da Cruz e Silva OA
Ann N Y Acad Sci. 2007
PubMed ID: 17405930
Release of beta-amyloid from high-density platelets: implications for Alzheimer's disease pathology.
Casoli T, Di Stefano G, Giorgetti B, Grossi Y, Balietti M, Fattoretti P, Bertoni-Freddari C
Ann N Y Acad Sci. 2007
PubMed ID: 17405928
Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins.
Carey BW, Kim DY, Kovacs DM
Biochem J. 2007
PubMed ID: 17150042
Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).
Müller T, Concannon CG, Ward MW, Walsh CM, Tirniceriu AL, Tribl F, Kögel D, Prehn JH, Egensperger R
Mol Biol Cell. 2007
PubMed ID: 17093061
Time-dependent DNA condensation induced by amyloid beta-peptide.
Yu H, Ren J, Qu X
Biophys J. 2007
PubMed ID: 17028131
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.
Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF
J Neurosci. 2006
PubMed ID: 17192425
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs DH, LaFerla FM
J Biol Chem. 2006
PubMed ID: 17056594
The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.
Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A
Biochem Biophys Res Commun. 2006
PubMed ID: 17054906
Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.
Sano Y, Syuzo-Takabatake A, Nakaya T, Saito Y, Tomita S, Itohara S, Suzuki T
J Biol Chem. 2006
PubMed ID: 17032642
Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain.
Abad MA, Enguita M, DeGregorio-Rocasolano N, Ferrer I, Trullas R
J Neurosci. 2006
PubMed ID: 17151277
Amyloid precursor protein modulates ERK-1 and -2 signaling.
Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C
Ann N Y Acad Sci. 2006
PubMed ID: 17384289
Mitochondrial dysfunction and Alzheimer's disease.
Chen X, Stern D, Yan SD
Curr Alzheimer Res. 2006
PubMed ID: 17168650
Lipid-induced beta-amyloid peptide assemblage fragmentation.
Widenbrant MJ, Rajadas J, Sutardja C, Fuller GG
Biophys J. 2006
PubMed ID: 17098805
Beta-amyloid aggregation in human brains with cerebrovascular lesions.
Aho L, Jolkkonen J, Alafuzoff I
Stroke. 2006
PubMed ID: 17095738
AbetaPP-overexpression and proteasome inhibition increase alphaB-crystallin in cultured human muscle: relevance to inclusion-body myositis.
Wojcik S, Engel WK, McFerrin J, Paciello O, Askanas V
Neuromuscul Disord. 2006
PubMed ID: 17056255
siRNA targeted against amyloid precursor protein impairs synaptic activity in vivo.
Hérard AS, Besret L, Dubois A, Dauguet J, Delzescaux T, Hantraye P, Bonvento G, Moya KL
Neurobiol Aging. 2006
PubMed ID: 16337035
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice.
Zerbinatti CV, Wahrle SE, Kim H, Cam JA, Bales K, Paul SM, Holtzman DM, Bu G
J Biol Chem. 2006
PubMed ID: 17012232
Structural and thermodynamical properties of CuII amyloid-beta16/28 complexes associated with Alzheimer's disease.
Guilloreau L, Damian L, Coppel Y, Mazarguil H, Winterhalter M, Faller P
J Biol Inorg Chem. 2006
PubMed ID: 16924555
Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference.
Sakai T, Hohjoh H
Cell Biol Int. 2006
PubMed ID: 16889988
alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35.
Narayanan S, Kamps B, Boelens WC, Reif B
FEBS Lett. 2006
PubMed ID: 17046756
Amyloid fibril formation and other aggregate species formed by human serum albumin association.
Taboada P, Barbosa S, Castro E, Mosquera V
J Phys Chem B. 2006
PubMed ID: 17048876
Amyloid beta oligomerization is induced by brain lipid rafts.
Kim SI, Yi JS, Ko YG
J Cell Biochem. 2006
PubMed ID: 16721824
Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.
Eckman EA, Adams SK, Troendle FJ, Stodola BA, Kahn MA, Fauq AH, Xiao HD, Bernstein KE, Eckman CB
J Biol Chem. 2006
PubMed ID: 16912050
Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis.
Veereshwarayya V, Kumar P, Rosen KM, Mestril R, Querfurth HW
J Biol Chem. 2006
PubMed ID: 16887805
Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.
Moussa CE, Fu Q, Kumar P, Shtifman A, Lopez JR, Allen PD, LaFerla F, Weinberg D, Magrane J, Aprahamian T, Walsh K, Rosen KM, Querfurth HW
FASEB J. 2006
PubMed ID: 16940437
A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing.
Yogev-Falach M, Bar-Am O, Amit T, Weinreb O, Youdim MB
FASEB J. 2006
PubMed ID: 16935943
Elevated levels of amyloid precursor protein in muscle of patients with amyotrophic lateral sclerosis and a mouse model of the disease.
Koistinen H, Prinjha R, Soden P, Harper A, Banner SJ, Pradat PF, Loeffler JP, Dingwall C
Muscle Nerve. 2006
PubMed ID: 16856153
Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.
Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA
J Biol Chem. 2006
PubMed ID: 16849336
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT
J Neurosci. 2006
PubMed ID: 17005855
Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide.
Sachse C, Xu C, Wieligmann K, Diekmann S, Grigorieff N, Fändrich M
J Mol Biol. 2006
PubMed ID: 16920151
Opposing activities protect against age-onset proteotoxicity.
Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A
Science. 2006
PubMed ID: 16902091
Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease.
Mandal PK, Pettegrew JW, Masliah E, Hamilton RL, Mandal R
Neurochem Res. 2006
PubMed ID: 16947080
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology.
Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M
EMBO Rep. 2006
PubMed ID: 16906128
The conformations of the amyloid-beta (21-30) fragment can be described by three families in solution.
Chen W, Mousseau N, Derreumaux P
J Chem Phys. 2006
PubMed ID: 16965061
Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids.
Sciarretta KL, Boire A, Gordon DJ, Meredith SC
Biochemistry. 2006
PubMed ID: 16878983
Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease?
Coulson EJ
J Neurochem. 2006
PubMed ID: 16893414
Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, Paulus W, Keyvani K
Am J Pathol. 2006
PubMed ID: 16877355
Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease.
Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM
Acta Neuropathol. 2006
PubMed ID: 16865398
Rimmed vacuoles with beta-amyloid and tau protein deposits in the muscle of children with hereditary myopathy.
Fidziańska A, Glinka Z
Acta Neuropathol. 2006
PubMed ID: 16788822
Mapping genetic modulators of amyloid plaque deposition in TgCRND8 transgenic mice.
Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, Gervais F, Tremblay P
Hum Mol Genet. 2006
PubMed ID: 16785251
Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia.
Wilkinson B, Koenigsknecht-Talboo J, Grommes C, Lee CY, Landreth G
J Biol Chem. 2006
PubMed ID: 16728400
Alzheimer's disease beta-amyloid peptides are released in association with exosomes.
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16837572
ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.
Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ
J Biol Chem. 2006
PubMed ID: 16714296
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Salehi A, Delcroix JD, Belichenko PV, Zhan K, Wu C, Valletta JS, Takimoto-Kimura R, Kleschevnikov AM, Sambamurti K, Chung PP, Xia W, Villar A, Campbell WA, Kulnane LS, Nixon RA, Lamb BT, Epstein CJ, Stokin GB, Goldstein LS, Mobley WC
Neuron. 2006
PubMed ID: 16815330
Synapse formation and function is modulated by the amyloid precursor protein.
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J
J Neurosci. 2006
PubMed ID: 16822978
Selectively increased oxidative modifications mapped to detergent-insoluble forms of Abeta and beta-III tubulin in Alzheimer's disease.
Boutte AM, Woltjer RL, Zimmerman LJ, Stamer SL, Montine KS, Manno MV, Cimino PJ, Liebler DC, Montine TJ
FASEB J. 2006
PubMed ID: 16816122
BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome.
Sun X, He G, Song W
FASEB J. 2006
PubMed ID: 16816112
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.
Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM
Traffic. 2006
PubMed ID: 16734669
Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro.
Siemes C, Quast T, Kummer C, Wehner S, Kirfel G, Müller U, Herzog V
Exp Cell Res. 2006
PubMed ID: 16584729
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
Huang SM, Mouri A, Kokubo H, Nakajima R, Suemoto T, Higuchi M, Staufenbiel M, Noda Y, Yamaguchi H, Nabeshima T, Saido TC, Iwata N
J Biol Chem. 2006
PubMed ID: 16636059
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein.
Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J
J Biol Chem. 2006
PubMed ID: 16624814
Amyloid precursor protein regulates differentiation of human neural stem cells.
Kwak YD, Brannen CL, Qu T, Kim HM, Dong X, Soba P, Majumdar A, Kaplan A, Beyreuther K, Sugaya K
Stem Cells Dev. 2006
PubMed ID: 16846375
Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice.
Kitazawa M, Green KN, Caccamo A, LaFerla FM
Am J Pathol. 2006
PubMed ID: 16723713
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.
Nakaya T, Suzuki T
Genes Cells. 2006
PubMed ID: 16716194
Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.
Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK, Suh YH
Mol Cell Biol. 2006
PubMed ID: 16705182
Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
Theuns J, Brouwers N, Engelborghs S, Sleegers K, Bogaerts V, Corsmit E, De Pooter T, van Duijn CM, De Deyn PP, Van Broeckhoven C
Am J Hum Genet. 2006
PubMed ID: 16685645
Nonprogressive transgene-related callosal and hippocampal changes in PDAPP mice.
Valla J, Schneider LE, Gonzalez-Lima F, Reiman EM
Neuroreport. 2006
PubMed ID: 16708023
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y
J Biol Chem. 2006
PubMed ID: 16595682
PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.
Choi DS, Wang D, Yu GQ, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK, Mucke L, Messing RO
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16698938
Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.
Rosen KM, Veereshwarayya V, Moussa CE, Fu Q, Goldberg MS, Schlossmacher MG, Shen J, Querfurth HW
J Biol Chem. 2006
PubMed ID: 16517603
Nuclear factor-kappaB activated by capacitative Ca2+ entry enhances muscarinic receptor-mediated soluble amyloid precursor protein (sAPPalpha) release in SH-SY5Y cells.
Choi S, Kim JH, Roh EJ, Ko MJ, Jung JE, Kim HJ
J Biol Chem. 2006
PubMed ID: 16490783
Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.
Galvan V, Gorostiza OF, Banwait S, Ataie M, Logvinova AV, Sitaraman S, Carlson E, Sagi SA, Chevallier N, Jin K, Greenberg DA, Bredesen DE
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16641106
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.
Sato T, Kienlen-Campard P, Ahmed M, Liu W, Li H, Elliott JI, Aimoto S, Constantinescu SN, Octave JN, Smith SO
Biochemistry. 2006
PubMed ID: 16634632
[Expression levels of APP and PS1 genes in patients with Alzheimer's disease]
Zhang Y, Qian YP, Jiang KD, Yu SY, Wang DX, Zhang MY, Jiang SD
Yi Chuan. 2006
PubMed ID: 16735229
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
Anantharaman M, Tangpong J, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, St Clair DK
Am J Pathol. 2006
PubMed ID: 16651627
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A
Mol Cell Biol. 2006
PubMed ID: 16648485
Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia.
Haglund M, Kalaria R, Slade JY, Englund E
Acta Neuropathol. 2006
PubMed ID: 16555084
Exploring a mathematical model for the kinetics of beta-amyloid molecular imaging probes through a critical analysis of plaque pathology.
Shoghi-Jadid K, Barrio JR, Kepe V, Huang SC
Mol Imaging Biol. 2006
PubMed ID: 16552500
Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression.
Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH
Hum Mol Genet. 2006
PubMed ID: 16551656
The endogenous estrogen status regulates microglia reactivity in animal models of neuroinflammation.
Vegeto E, Belcredito S, Ghisletti S, Meda C, Etteri S, Maggi A
Endocrinology. 2006
PubMed ID: 16469811
Genetic study of Sardinian patients with Alzheimer's disease.
Piscopo P, Manfredi A, Malvezzi-Campeggi L, Crestini A, Spadoni O, Cherchi R, Deiana E, Piras MR, Confaloni A
Neurosci Lett. 2006
PubMed ID: 16423463
Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing.
Kang MJ, Chung YH, Hwang CI, Murata M, Fujimoto T, Mook-Jung IH, Cha CI, Park WY
Exp Mol Med. 2006
PubMed ID: 16672766
Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in an amyotrophic lateral sclerosis mouse model.
Li QX, Mok SS, Laughton KM, McLean CA, Volitakis I, Cherny RA, Cheung NS, White AR, Masters CL
Aging Cell. 2006
PubMed ID: 16626394
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface.
Kaether C, Schmitt S, Willem M, Haass C
Traffic. 2006
PubMed ID: 16536739
Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model.
Jeong YH, Park CH, Yoo J, Shin KY, Ahn SM, Kim HS, Lee SH, Emson PC, Suh YH
FASEB J. 2006
PubMed ID: 16467370
High density lipoproteins bind Abeta and apolipoprotein C-II amyloid fibrils.
Wilson LM, Pham CL, Jenkins AJ, Wade JD, Hill AF, Perugini MA, Howlett GJ
J Lipid Res. 2006
PubMed ID: 16432277
Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein.
Lee KW, Im JY, Song JS, Lee SH, Lee HJ, Ha HY, Koh JY, Gwag BJ, Yang SD, Paik SG, Han PL
Neurobiol Dis. 2006
PubMed ID: 16289866
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.
Chen TY, Liu PH, Ruan CT, Chiu L, Kung FL
Biochem Biophys Res Commun. 2006
PubMed ID: 16480949
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease.
Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16549802
Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression.
Nilsson T, Malkiewicz K, Gabrielsson M, Folkesson R, Winblad B, Benedikz E
Biochem Biophys Res Commun. 2006
PubMed ID: 16469300
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein.
Gralle M, Oliveira CL, Guerreiro LH, McKinstry WJ, Galatis D, Masters CL, Cappai R, Parker MW, Ramos CH, Torriani I, Ferreira ST
J Mol Biol. 2006
PubMed ID: 16436282
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M
J Biol Chem. 2006
PubMed ID: 16434391
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP
Nature. 2006
PubMed ID: 16554819
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF
J Biol Chem. 2006
PubMed ID: 16344553
A specific amyloid-beta protein assembly in the brain impairs memory.
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH
Nature. 2006
PubMed ID: 16541076
Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies.
Deramecourt V, Bombois S, Maurage CA, Ghestem A, Drobecq H, Vanmechelen E, Lebert F, Pasquier F, Delacourte A
J Neuropathol Exp Neurol. 2006
PubMed ID: 16651889
Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for
Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA
J Neurochem. 2006
PubMed ID: 16478525
The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein.
Kojro E, Postina R, Buro C, Meiringer C, Gehrig-Burger K, Fahrenholz F
FASEB J. 2006
PubMed ID: 16401644
Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes.
De Schepper S, Boucneau JM, Westbroek W, Mommaas M, Onderwater J, Messiaen L, Naeyaert JM, Lambert JL
J Invest Dermatol. 2006
PubMed ID: 16374483
Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model.
Sugarman MC, Kitazawa M, Baker M, Caiozzo VJ, Querfurth HW, LaFerla FM
Neurobiol Aging. 2006
PubMed ID: 15950323
Comparative analysis of cortical gene expression in mouse models of Alzheimer's disease.
Wu ZL, Ciallella JR, Flood DG, O'Kane TM, Bozyczko-Coyne D, Savage MJ
Neurobiol Aging. 2006
PubMed ID: 15927307
A second family with familial AD and the V717L APP mutation has a later age at onset.
Godbolt AK, Beck JA, Collinge JC, Cipolotti L, Fox NC, Rossor MN
Neurology. 2006
PubMed ID: 16505331
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
Atamna H, Boyle K
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16492752
AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.
Chang EH, Savage MJ, Flood DG, Thomas JM, Levy RB, Mahadomrongkul V, Shirao T, Aoki C, Huerta PT
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16492745
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE
Biochemistry. 2006
PubMed ID: 16489755
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
Tanemura K, Chui DH, Fukuda T, Murayama M, Park JM, Akagi T, Tatebayashi Y, Miyasaka T, Kimura T, Hashikawa T, Nakano Y, Kudo T, Takeda M, Takashima A
J Biol Chem. 2006
PubMed ID: 16377636
Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16449385
Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
Guo JP, Arai T, Miklossy J, McGeer PL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16446437
Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.
Kern A, Roempp B, Prager K, Walter J, Behl C
J Biol Chem. 2006
PubMed ID: 16303768
Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.
Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW
J Biol Chem. 2006
PubMed ID: 16298992
[Recurrent intraparenchimal haemorrhages in a patient with cerebral amyloidotic angiopathy: description of one autopsy case]
Gallo C, Orlassino R, Vineis C
Pathologica. 2006
PubMed ID: 16789686
Evidence against the overexpression of APP in Down syndrome.
Argellati F, Massone S, d'Abramo C, Marinari UM, Pronzato MA, Domenicotti C, Ricciarelli R
IUBMB Life. 2006
PubMed ID: 16608822
Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.
Wilhelmus MM, Boelens WC, Otte-Höller I, Kamps B, Kusters B, Maat-Schieman ML, de Waal RM, Verbeek MM
Acta Neuropathol. 2006
PubMed ID: 16485107
Beta-protein/A4 deposits are not associated with hyperphosphorylated tau in somatostatin neurons in the hypothalamus of Alzheimer's disease patients.
van de Nes JA, Konermann S, Nafe R, Swaab DF
Acta Neuropathol. 2006
PubMed ID: 16456666
Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription.
Li Y, Zhou W, Tong Y, He G, Song W
FASEB J. 2006
PubMed ID: 16449801
Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors.
Spencer JP, Weil A, Hill K, Hussain I, Richardson JC, Cusdin FS, Chen YH, Randall AD
Neuroscience. 2006
PubMed ID: 16303255
Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins.
Li X, Bürklen T, Yuan X, Schlattner U, Desiderio DM, Wallimann T, Homayouni R
Mol Cell Neurosci. 2006
PubMed ID: 16260146
Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells.
Matsumoto K, Akao Y, Yi H, Shamoto-Nagai M, Maruyama W, Naoi M
J Neural Transm. 2006
PubMed ID: 15959846
Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes.
Singer SJ, Dewji NN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432204
An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures.
Dewji NN, Mukhopadhyay D, Singer SJ
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16432203
Structural changes of region 1-16 of the Alzheimer disease amyloid beta-peptide upon zinc binding and in vitro aging.
Zirah S, Kozin SA, Mazur AK, Blond A, Cheminant M, Ségalas-Milazzo I, Debey P, Rebuffat S
J Biol Chem. 2006
PubMed ID: 16301322
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
Guénette S, Chang Y, Hiesberger T, Richardson JA, Eckman CB, Eckman EA, Hammer RE, Herz J
EMBO J. 2006
PubMed ID: 16407979
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments.
Vetrivel KS, Thinakaran G
Neurology. 2006
PubMed ID: 16432149
Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology.
Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM
J Biol Chem. 2006
PubMed ID: 16282321
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.
Gobbi M, Colombo L, Morbin M, Mazzoleni G, Accardo E, Vanoni M, Del Favero E, Cantù L, Kirschner DA, Manzoni C, Beeg M, Ceci P, Ubezio P, Forloni G, Tagliavini F, Salmona M
J Biol Chem. 2006
PubMed ID: 16286452
Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils.
Shivaprasad S, Wetzel R
J Biol Chem. 2006
PubMed ID: 16263715
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT
J Neurosci. 2006
PubMed ID: 16407538
The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.
Olofsson A, Sauer-Eriksson AE, Ohman A
J Biol Chem. 2006
PubMed ID: 16215229
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.
Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T
PLoS ONE. 2006
PubMed ID: 17183681
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerrière A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D
Nat Genet. 2006
PubMed ID: 16369530
New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.
Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P
Front Biosci. 2006
PubMed ID: 16368544
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice.
Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L, Nilsson LN
Neurobiol Aging. 2006
PubMed ID: 16298242
Ion channel formation by Alzheimer's disease amyloid beta-peptide (Abeta40) in unilamellar liposomes is determined by anionic phospholipids.
Alarcón JM, Brito JA, Hermosilla T, Atwater I, Mears D, Rojas E
Peptides. 2006
PubMed ID: 16139931
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Wahrle SE, Jiang H, Parsadanian M, Hartman RE, Bales KR, Paul SM, Holtzman DM
J Biol Chem. 2005
PubMed ID: 16207708
The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.
Hirsch-Reinshagen V, Maia LF, Burgess BL, Blain JF, Naus KE, McIsaac SA, Parkinson PF, Chan JY, Tansley GH, Hayden MR, Poirier J, Van Nostrand W, Wellington CL
J Biol Chem. 2005
PubMed ID: 16207707
Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.
Yue X, Lu M, Lancaster T, Cao P, Honda S, Staufenbiel M, Harada N, Zhong Z, Shen Y, Li R
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16365303
Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.
Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16344478
Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.
Masuda Y, Irie K, Murakami K, Ohigashi H, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T
Bioorg Med Chem. 2005
PubMed ID: 16182533
AlphaB-crystallin, a small heat-shock protein, prevents the amyloid fibril growth of an amyloid beta-peptide and beta2-microglobulin.
Raman B, Ban T, Sakai M, Pasta SY, Ramakrishna T, Naiki H, Goto Y, Rao ChM
Biochem J. 2005
PubMed ID: 16053447
BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.
Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC
J Neurosci. 2005
PubMed ID: 16354928
Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation.
Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF
J Neurosci. 2005
PubMed ID: 16354912
Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis.
Xu F, Davis J, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16330760
Beta-secretase-cleaved amyloid precursor protein accumulates at actin inclusions induced in neurons by stress or amyloid beta: a feedforward mechanism for Alzheimer's disease.
Maloney MT, Minamide LS, Kinley AW, Boyle JA, Bamburg JR
J Neurosci. 2005
PubMed ID: 16339026
Stability of the distribution of spines containing drebrin A in the sensory cortex layer I of mice expressing mutated APP and PS1 genes.
Mahadomrongkul V, Huerta PT, Shirao T, Aoki C
Brain Res. 2005
PubMed ID: 16325786
The amyloid-beta precursor protein: integrating structure with biological function.
Reinhard C, Hébert SS, De Strooper B
EMBO J. 2005
PubMed ID: 16252002
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L
J Biol Chem. 2005
PubMed ID: 16183991
Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease.
Watson D, Castaño E, Kokjohn TA, Kuo YM, Lyubchenko Y, Pinsky D, Connolly ES, Esh C, Luehrs DC, Stine WB, Rowse LM, Emmerling MR, Roher AE
Neurol Res. 2005
PubMed ID: 16354549
Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.
Cao Q, Huang YS, Kan MC, Richter JD
Mol Cell Biol. 2005
PubMed ID: 16314516
Lead (Pb) exposure and its effect on APP proteolysis and Abeta aggregation.
Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH
FASEB J. 2005
PubMed ID: 16230335
Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage.
Ferrer I, Kapfhammer JP, Hindelang C, Kemp S, Troffer-Charlier N, Broccoli V, Callyzot N, Mooyer P, Selhorst J, Vreken P, Wanders RJ, Mandel JL, Pujol A
Hum Mol Genet. 2005
PubMed ID: 16223892
CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid beta 1-42 peptide by up-regulating the expression of the G-protein- coupled receptor mFPR2.
Iribarren P, Chen K, Hu J, Gong W, Cho EH, Lockett S, Uranchimeg B, Wang JM
FASEB J. 2005
PubMed ID: 16219804
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.
Caspersen C, Wang N, Yao J, Sosunov A, Chen X, Lustbader JW, Xu HW, Stern D, McKhann G, Yan SD
FASEB J. 2005
PubMed ID: 16210396
Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease.
Cumming RC, Schubert D
FASEB J. 2005
PubMed ID: 16186172
Amyloid peptide attenuates the proteasome activity in neuronal cells.
Oh S, Hong HS, Hwang E, Sim HJ, Lee W, Shin SJ, Mook-Jung I
Mech Ageing Dev. 2005
PubMed ID: 16153690
Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.
Ribé EM, Pérez M, Puig B, Gich I, Lim F, Cuadrado M, Sesma T, Catena S, Sánchez B, Nieto M, Gómez-Ramos P, Morán MA, Cabodevilla F, Samaranch L, Ortiz L, Pérez A, Ferrer I, Avila J, Gómez-Isla T
Neurobiol Dis. 2005
PubMed ID: 16125396
Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.
Muresan Z, Muresan V
J Cell Biol. 2005
PubMed ID: 16301330
Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.
Perez SE, Lazarov O, Koprich JB, Chen EY, Rodriguez-Menendez V, Lipton JW, Sisodia SS, Mufson EJ
J Neurosci. 2005
PubMed ID: 16267229
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD
J Proteome Res. 2005
PubMed ID: 16335952
Substitution of methionine 35 inhibits apoptotic effects of Abeta(31-35) and Abeta(25-35) fragments of amyloid-beta protein in PC12 cells.
Clementi ME, Misiti F
Med Sci Monit. 2005
PubMed ID: 16258386
Regulation of lung injury and repair by Toll-like receptors and hyaluronan.
Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, Prestwich GD, Mascarenhas MM, Garg HG, Quinn DA, Homer RJ, Goldstein DR, Bucala R, Lee PJ, Medzhitov R, Noble PW
Nat Med. 2005
PubMed ID: 16244651
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.
Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK
Neurobiol Dis. 2005
PubMed ID: 16242627
Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein.
Hashimoto Y, Chiba T, Yamada M, Nawa M, Kanekura K, Suzuki H, Terashita K, Aiso S, Nishimoto I, Matsuoka M
Mol Cell Biol. 2005
PubMed ID: 16227582
Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner.
Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E
Acta Neuropathol. 2005
PubMed ID: 16195918
SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain.
Madeira A, Pommet JM, Prochiantz A, Allinquant B
FASEB J. 2005
PubMed ID: 16162853
Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease.
Barghorn S, Nimmrich V, Striebinger A, Krantz C, Keller P, Janson B, Bahr M, Schmidt M, Bitner RS, Harlan J, Barlow E, Ebert U, Hillen H
J Neurochem. 2005
PubMed ID: 16135089
Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease.
Woltjer RL, Cimino PJ, Boutté AM, Schantz AM, Montine KS, Larson EB, Bird T, Quinn JF, Zhang J, Montine TJ
FASEB J. 2005
PubMed ID: 16129700
Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death.
d'Abramo C, Massone S, Zingg JM, Pizzuti A, Marambaud P, Dalla Piccola B, Azzi A, Marinari UM, Pronzato MA, Ricciarelli R
Biochem J. 2005
PubMed ID: 15946122
Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N
Neurobiol Dis. 2005
PubMed ID: 15936948
Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels.
Köhler C, Ebert U, Baumann K, Schröder H
Neurobiol Dis. 2005
PubMed ID: 15921918
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain.
Ryan KA, Pimplikar SW
J Cell Biol. 2005
PubMed ID: 16230462
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K
EMBO J. 2005
PubMed ID: 16193067
Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.
Kim W, Hecht MH
J Biol Chem. 2005
PubMed ID: 16079141
Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence.
Maji SK, Amsden JJ, Rothschild KJ, Condron MM, Teplow DB
Biochemistry. 2005
PubMed ID: 16201761
A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, Arbustini E, Palladini G, Diegoli M, Genovese E, Ferrari G, Coverlizza S, Merlini G
Ann Neurol. 2005
PubMed ID: 16178030
Amyloid precursor protein interacts with notch receptors.
Oh SY, Ellenstein A, Chen CD, Hinman JD, Berg EA, Costello CE, Yamin R, Neve RL, Abraham CR
J Neurosci Res. 2005
PubMed ID: 16118793
The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos.
Yang J, Li T
Exp Cell Res. 2005
PubMed ID: 16018997
Ultrasonication-induced amyloid fibril formation of beta2-microglobulin.
Ohhashi Y, Kihara M, Naiki H, Goto Y
J Biol Chem. 2005
PubMed ID: 16046408
Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.
Kelly BL, Vassar R, Ferreira A
J Biol Chem. 2005
PubMed ID: 16002400
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S
J Biol Chem. 2005
PubMed ID: 16027166
Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.
Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI
J Clin Invest. 2005
PubMed ID: 16127459
Ectoine and hydroxyectoine inhibit aggregation and neurotoxicity of Alzheimer's beta-amyloid.
Kanapathipillai M, Lentzen G, Sierks M, Park CB
FEBS Lett. 2005
PubMed ID: 16098972
Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid.
Alarcón R, Fuenzalida C, Santibáñez M, von Bernhardi R
J Biol Chem. 2005
PubMed ID: 15987691
Protofibril formation of amyloid beta-protein at low pH via a non-cooperative elongation mechanism.
Carrotta R, Manno M, Bulone D, Martorana V, San Biagio PL
J Biol Chem. 2005
PubMed ID: 15985437
Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain.
Leyssen M, Ayaz D, Hébert SS, Reeve S, De Strooper B, Hassan BA
EMBO J. 2005
PubMed ID: 16052209
Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques.
Miravalle L, Calero M, Takao M, Roher AE, Ghetti B, Vidal R
Biochemistry. 2005
PubMed ID: 16086583
The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production.
Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L
J Biol Chem. 2005
PubMed ID: 15983050
Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.
Yang G, Gong YD, Gong K, Jiang WL, Kwon E, Wang P, Zheng H, Zhang XF, Gan WB, Zhao NM
Neurosci Lett. 2005
PubMed ID: 15919150
[Expression of beta-amyloid precursor protein in diffuse axonal injury of rats]
Zhu JL, Zhu SH, Ren L
Fa Yi Xue Za Zhi. 2005
PubMed ID: 16259359
The role of Abeta peptides in Alzheimer's disease.
Tickler AK, Wade JD, Separovic F
Protein Pept Lett. 2005
PubMed ID: 16101387
Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.
Miao J, Xu F, Davis J, Otte-Höller I, Verbeek MM, Van Nostrand WE
Am J Pathol. 2005
PubMed ID: 16049335
Regulation of NMDA receptor trafficking by amyloid-beta.
Snyder EM, Nong Y, Almeida CG, Paul S, Moran T, Choi EY, Nairn AC, Salter MW, Lombroso PJ, Gouras GK, Greengard P
Nat Neurosci. 2005
PubMed ID: 16025111
Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide.
Christopeit T, Hortschansky P, Schroeckh V, Gührs K, Zandomeneghi G, Fändrich M
Protein Sci. 2005
PubMed ID: 15987892
Imipramine and citalopram facilitate amyloid precursor protein secretion in vitro.
Pákáski M, Bjelik A, Hugyecz M, Kása P, Janka Z, Kálmán J
Neurochem Int. 2005
PubMed ID: 15955598
Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
Tamboli IY, Prager K, Barth E, Heneka M, Sandhoff K, Walter J
J Biol Chem. 2005
PubMed ID: 15923191
Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival.
Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K
J Neurosci. 2005
PubMed ID: 16049186
Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS, Thinakaran G
J Biol Chem. 2005
PubMed ID: 15886206
Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides.
Guo M, Gorman PM, Rico M, Chakrabartty A, Laurents DV
FEBS Lett. 2005
PubMed ID: 15964569
mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease.
Lafay-Chebassier C, Paccalin M, Page G, Barc-Pain S, Perault-Pochat MC, Gil R, Pradier L, Hugon J
J Neurochem. 2005
PubMed ID: 15953364
TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.
Laws SM, Perneczky R, Wagenpfeil S, Müller U, Förstl H, Martins RN, Kurz A, Riemenschneider M
Hum Mutat. 2005
PubMed ID: 15895461
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity.
Lesné S, Gabriel C, Nelson DA, White E, Mackenzie ET, Vivien D, Buisson A
J Biol Chem. 2005
PubMed ID: 15797869
Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.
Hartman RE, Izumi Y, Bales KR, Paul SM, Wozniak DF, Holtzman DM
J Neurosci. 2005
PubMed ID: 15987951
An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease.
Marchesi VT
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15967987
In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid.
Erickson RR, Dunning LM, Olson DA, Cohen SJ, Davis AT, Wood WG, Kratzke RA, Holtzman JL
Biochem Biophys Res Commun. 2005
PubMed ID: 15896298
Estradiol regulates APP mRNA alternative splicing in the mice brain cortex.
Thakur MK, Mani ST
Neurosci Lett. 2005
PubMed ID: 15882808
Hypoxic augmentation of Ca2+ channel currents requires a functional electron transport chain.
Brown ST, Scragg JL, Boyle JP, Hudasek K, Peers C, Fearon IM
J Biol Chem. 2005
PubMed ID: 15824110
Metals and amyloid-beta in Alzheimer's disease.
Maynard CJ, Bush AI, Masters CL, Cappai R, Li QX
Int J Exp Pathol. 2005
PubMed ID: 15910549
Short-term interleukin-1(beta) increases the release of secreted APP(alpha) via MEK1/2-dependent and JNK-dependent alpha-secretase cleavage in neuroglioma U251 cells.
Ma G, Chen S, Wang X, Ba M, Yang H, Lu G
J Neurosci Res. 2005
PubMed ID: 15880353
Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients.
Calingasan NY, Chen J, Kiaei M, Beal MF
Neurobiol Dis. 2005
PubMed ID: 15837590
Inhibition of Alzheimer's amyloid-beta peptide-induced reduction of mitochondrial membrane potential and neurotoxicity by gelsolin.
Qiao H, Koya RC, Nakagawa K, Tanaka H, Fujita H, Takimoto M, Kuzumaki N
Neurobiol Aging. 2005
PubMed ID: 15718043
Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.
Blomqvist ME, Chalmers K, Andreasen N, Bogdanovic N, Wilcock GK, Cairns NJ, Feuk L, Brookes AJ, Love S, Blennow K, Kehoe PG, Prince JA
Neurobiol Aging. 2005
PubMed ID: 15718037
Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling.
Yoon IS, Pietrzik CU, Kang DE, Koo EH
J Biol Chem. 2005
PubMed ID: 15772078
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Müller U, St George Hyslop P, Checler F
Neuron. 2005
PubMed ID: 15944124
Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein.
Chen M, Fernandez HL
Biochem Biophys Res Commun. 2005
PubMed ID: 15809056
P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing.
Camden JM, Schrader AM, Camden RE, González FA, Erb L, Seye CI, Weisman GA
J Biol Chem. 2005
PubMed ID: 15778502
SOD-1 inhibits FAS expression in cortex of APP transgenic mice.
Chen Z, Duan RS, Lepécheur M, Paly E, London J, Zhu J
Apoptosis. 2005
PubMed ID: 15909112
Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.
Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T
Am J Pathol. 2005
PubMed ID: 15855647
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo.
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ
Nat Med. 2005
PubMed ID: 15834427
Novel mutations and repeated findings of mutations in familial Alzheimer disease.
Finckh U, Kuschel C, Anagnostouli M, Patsouris E, Pantes GV, Gatzonis S, Kapaki E, Davaki P, Lamszus K, Stavrou D, Gal A
Neurogenetics. 2005
PubMed ID: 15776278
Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice.
Boncristiano S, Calhoun ME, Howard V, Bondolfi L, Kaeser SA, Wiederhold KH, Staufenbiel M, Jucker M
Neurobiol Aging. 2005
PubMed ID: 15708435
Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.
Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE
J Biol Chem. 2005
PubMed ID: 15728175
Catechol oxidase-like oxidation chemistry of the 1-20 and 1-16 fragments of Alzheimer's disease-related beta-amyloid peptide: their structure-activity correlation and the fate of hydrogen peroxide.
da Silva GF, Tay WM, Ming LJ
J Biol Chem. 2005
PubMed ID: 15699049
Implications of the serine protease HtrA1 in amyloid precursor protein processing.
Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, Richards P, Jones SA, Shridhar V, Clausen T, Ehrmann M
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15855271
Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein.
Cam JA, Zerbinatti CV, Li Y, Bu G
J Biol Chem. 2005
PubMed ID: 15705569
RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing.
Xie Z, Romano DM, Tanzi RE
J Biol Chem. 2005
PubMed ID: 15699037
Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development.
Kerr ML, Small DH
J Neurosci Res. 2005
PubMed ID: 15672415
The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.
Cappai R, Cheng F, Ciccotosto GD, Needham BE, Masters CL, Multhaup G, Fransson LA, Mani K
J Biol Chem. 2005
PubMed ID: 15677459
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.
Willnow T, Antignac C, Brändli A, Christensen E, Cox R, Davidson D, Davies J, Devuyst O, Eichele G, Hastie N, Verroust P, Schedl A, Meij I
Organogenesis. 2005
PubMed ID: 19521566
[The interaction of the intracellular domain of beta-amyloid precursor protein with JKTBP2]
Wang WW, Li ZD, Liu RZ, Hong SG, Xu XX, Chen YG
Shi Yan Sheng Wu Xue Bao. 2005
PubMed ID: 16011250
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M, Saido TC
Nat Med. 2005
PubMed ID: 15778722
Differential effects of oligomeric and fibrillar amyloid-beta 1-42 on astrocyte-mediated inflammation.
White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ
Neurobiol Dis. 2005
PubMed ID: 15755672
Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models.
Van Dam D, Marescau B, Engelborghs S, Cremers T, Mulder J, Staufenbiel M, De Deyn PP
Neurochem Int. 2005
PubMed ID: 15737439
Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide.
Ambroggio EE, Kim DH, Separovic F, Barrow CJ, Barnham KJ, Bagatolli LA, Fidelio GD
Biophys J. 2005
PubMed ID: 15681641
Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.
Hu Q, Wang L, Yang Z, Cool BH, Zitnik G, Martin GM
J Biol Chem. 2005
PubMed ID: 15647266
The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells.
Lee EO, Kang JL, Chong YH
J Biol Chem. 2005
PubMed ID: 15632190
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles.
Kim J, Hamamoto S, Ravazzola M, Orci L, Schekman R
J Biol Chem. 2005
PubMed ID: 15623526
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
Lockhart A, Ye L, Judd DB, Merritt AT, Lowe PN, Morgenstern JL, Hong G, Gee AD, Brown J
J Biol Chem. 2005
PubMed ID: 15615711
Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen-activated protein kinases.
Baranova IN, Vishnyakova TG, Bocharov AV, Kurlander R, Chen Z, Kimelman ML, Remaley AT, Csako G, Thomas F, Eggerman TL, Patterson AP
J Biol Chem. 2005
PubMed ID: 15576377
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice.
Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM
Neuron. 2005
PubMed ID: 15748844
Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS
J Neurosci. 2005
PubMed ID: 15745965
Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria.
Adamczyk A, Czapski GA, Jeśko H, Strosznajder RP
J Physiol Pharmacol. 2005
PubMed ID: 16077187
Temperature dependence of the nucleation constant rate in beta amyloid fibrillogenesis.
Sabaté R, Gallardo M, Estelrich J
Int J Biol Macromol. 2005
PubMed ID: 15769509
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.
Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS
Science. 2005
PubMed ID: 15731448
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
Nelson TJ, Alkon DL
J Biol Chem. 2005
PubMed ID: 15591071
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS
J Biol Chem. 2005
PubMed ID: 15557325
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.
Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H
J Neurosci. 2005
PubMed ID: 15689559
Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.
Yao M, Nguyen TV, Pike CJ
J Neurosci. 2005
PubMed ID: 15689551
Altered metabolic profile in the frontal cortex of PS2APP transgenic mice, monitored throughout their life span.
von Kienlin M, Künnecke B, Metzger F, Steiner G, Richards JG, Ozmen L, Jacobsen H, Loetscher H
Neurobiol Dis. 2005
PubMed ID: 15649694
Tat and amyloid: multiple interactions.
Nath A, Hersh LB
AIDS. 2005
PubMed ID: 15668546
HIV-1 Tat inhibits neprilysin and elevates amyloid beta.
Rempel HC, Pulliam L
AIDS. 2005
PubMed ID: 15668537
The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.
Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH
J Neurosci. 2005
PubMed ID: 15673661
An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.
Edwards-Lee T, Ringman JM, Chung J, Werner J, Morgan A, St George Hyslop P, Thompson P, Dutton R, Mlikotic A, Rogaeva E, Hardy J
Neurology. 2005
PubMed ID: 15668448
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.
Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R
Science. 2005
PubMed ID: 15653506
APP processing and the APP-KPI domain involvement in the amyloid cascade.
Menéndez-González M, Pérez-Pinera P, Martínez-Rivera M, Calatayud MT, Blázquez Menes B
Neurodegener Dis. 2005
PubMed ID: 16909010
Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease.
Kong GK, Galatis D, Barnham KJ, Polekhina G, Adams JJ, Masters CL, Cappai R, Parker MW, McKinstry WJ
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005
PubMed ID: 16508101
L-glutamate and phorbol ester stimulate the release of secretory amyloid precursor protein from rat cortical synaptosomes.
Kirazov L, Kirazovi E, Schliebs R
Acta Biol Hung. 2005
PubMed ID: 16196193
Herpes simplex virus interferes with amyloid precursor protein processing.
Shipley SJ, Parkin ET, Itzhaki RF, Dobson CB
BMC Microbiol. 2005
PubMed ID: 16109164
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein.
Carey RM, Balcz BA, Lopez-Coviella I, Slack BE
BMC Cell Biol. 2005
PubMed ID: 16095541
Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK.
Pedrini S, Carter TL, Prendergast G, Petanceska S, Ehrlich ME, Gandy S
PLoS Med. 2005
PubMed ID: 15647781
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities.
Lambourne SL, Sellers LA, Bush TG, Choudhury SK, Emson PC, Suh YH, Wilkinson LS
Mol Cell Biol. 2005
PubMed ID: 15601849
Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway.
Kögel D, Schomburg R, Copanaki E, Prehn JH
Cell Death Differ. 2005
PubMed ID: 15592359
Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein.
López-Sánchez N, Müller U, Frade JM
Neuroscience. 2005
PubMed ID: 15561424
Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy.
Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM
J Biol Chem. 2004
PubMed ID: 15489232
Calcium dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes.
Christensen RA, Shtifman A, Allen PD, Lopez JR, Querfurth HW
J Biol Chem. 2004
PubMed ID: 15385569
High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity.
Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S
J Neurosci Res. 2004
PubMed ID: 15499593
Gene expression profiling in chronic copper overload reveals upregulation of Prnp and App.
Armendariz AD, Gonzalez M, Loguinov AV, Vulpe CD
Physiol Genomics. 2004
PubMed ID: 15467011
Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.
Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, Shirasawa T
J Biol Chem. 2004
PubMed ID: 15459202
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT
J Biol Chem. 2004
PubMed ID: 15452128
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.
Tarassishin L, Yin YI, Bassit B, Li YM
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15563588
Neuronal membrane cholesterol loss enhances amyloid peptide generation.
Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG
J Cell Biol. 2004
PubMed ID: 15583033
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Benjannet S, Cromlish JA, Diallo K, Chrétien M, Seidah NG
Biochem Biophys Res Commun. 2004
PubMed ID: 15522224
Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.
Zhao G, Mao G, Tan J, Dong Y, Cui MZ, Kim SH, Xu X
J Biol Chem. 2004
PubMed ID: 15485850
Fibrillar amyloid-beta peptides kill human primary neurons via NADPH oxidase-mediated activation of neutral sphingomyelinase. Implications for Alzheimer's disease.
Jana A, Pahan K
J Biol Chem. 2004
PubMed ID: 15452132
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Interaction of human and mouse Abeta peptides.
Fung J, Frost D, Chakrabartty A, McLaurin J
J Neurochem. 2004
PubMed ID: 15584916
Upregulation of amyloid precursor protein isoforms containing Kunitz protease inhibitor in dementia with Lewy bodies.
Beyer K, Lao JI, Carrato C, Mate JL, López D, Ferrer I, Ariza A
Brain Res Mol Brain Res. 2004
PubMed ID: 15530662
The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice.
Lee JH, Lau KF, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CC
J Biol Chem. 2004
PubMed ID: 15347685
Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.
Ghersi E, Noviello C, D'Adamio L
J Biol Chem. 2004
PubMed ID: 15347684
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway.
Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS
J Biol Chem. 2004
PubMed ID: 15347683
Familial Alzheimer disease associated with A713T mutation in APP.
Armstrong J, Boada M, Rey MJ, Vidal N, Ferrer I
Neurosci Lett. 2004
PubMed ID: 15488330
Synaptic targeting by Alzheimer's-related amyloid beta oligomers.
Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL
J Neurosci. 2004
PubMed ID: 15537891
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.
Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, Shen J
J Biol Chem. 2004
PubMed ID: 15345711
Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport.
Khvotchev M, Südhof TC
J Biol Chem. 2004
PubMed ID: 15316009
Characterization of presenilin-amyloid precursor interaction using bacterial expression and two-hybrid systems for human membrane proteins.
Harnasch M, Grau S, Behrends C, Dove SL, Hochschild A, Iskandar MK, Xia W, Ehrmann M
Mol Membr Biol. 2004
PubMed ID: 15764367
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.
Gylys KH, Fein JA, Yang F, Wiley DJ, Miller CA, Cole GM
Am J Pathol. 2004
PubMed ID: 15509549
Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice.
Langui D, Girardot N, El Hachimi KH, Allinquant B, Blanchard V, Pradier L, Duyckaerts C
Am J Pathol. 2004
PubMed ID: 15509518
Mutations in APP have independent effects on Abeta and CTFgamma generation.
Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM
Neurobiol Dis. 2004
PubMed ID: 15474359
Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.
Herber DL, Roth LM, Wilson D, Wilson N, Mason JE, Morgan D, Gordon MN
Exp Neurol. 2004
PubMed ID: 15473997
Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation.
Gestwicki JE, Crabtree GR, Graef IA
Science. 2004
PubMed ID: 15514157
Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.
Frederikse PH, Yun E, Kao HT, Zigler JS, Sun Q, Qazi AS
Mol Vis. 2004
PubMed ID: 15529118
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation.
Dumont M, Strazielle C, Staufenbiel M, Lalonde R
Brain Res. 2004
PubMed ID: 15451372
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.
Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Müller U
EMBO J. 2004
PubMed ID: 15385965
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The beta-amyloid precursor protein controls a store-operated Ca2+ entry in cortical neurons.
Bouron A, Mbebi C, Loeffler JP, De Waard M
Eur J Neurosci. 2004
PubMed ID: 15450086
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT
Nat Med. 2004
PubMed ID: 15448688
Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.
Bellingham SA, Ciccotosto GD, Needham BE, Fodero LR, White AR, Masters CL, Cappai R, Camakaris J
J Neurochem. 2004
PubMed ID: 15447675
Methionine 35 oxidation reduces toxic effects of the amyloid beta-protein fragment (31-35) on human red blood cell.
Clementi ME, Martorana GE, Pezzotti M, Giardina B, Misiti F
Int J Biochem Cell Biol. 2004
PubMed ID: 15203119
A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.
Rossi G, Giaccone G, Maletta R, Morbin M, Capobianco R, Mangieri M, Giovagnoli AR, Bizzi A, Tomaino C, Perri M, Di Natale M, Tagliavini F, Bugiani O, Bruni AC
Neurology. 2004
PubMed ID: 15365148
Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1.
Qahwash I, He W, Tomasselli A, Kletzien RF, Yan R
J Biol Chem. 2004
PubMed ID: 15234966
Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Huang XP, Chang WP, Koelsch G, Turner RT, Lupu F, Tang J
J Biol Chem. 2004
PubMed ID: 15197182
Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.
Stein TD, Anders NJ, DeCarli C, Chan SL, Mattson MP, Johnson JA
J Neurosci. 2004
PubMed ID: 15342738
Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice.
Poon HF, Joshi G, Sultana R, Farr SA, Banks WA, Morley JE, Calabrese V, Butterfield DA
Brain Res. 2004
PubMed ID: 15262209
The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain.
Wang Y, Ha Y
Mol Cell. 2004
PubMed ID: 15304215
Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes.
Howlett DR, Richardson JC, Austin A, Parsons AA, Bate ST, Davies DC, Gonzalez MI
Brain Res. 2004
PubMed ID: 15261108
LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.
Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV
Neuron. 2004
PubMed ID: 15294142
Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein.
Dulubova I, Ho A, Huryeva I, Südhof TC, Rizo J
Biochemistry. 2004
PubMed ID: 15274612
Prevalence of pathogenic mutations in an Italian clinical series of patients with familial dementia.
Signorini S, Ghidoni R, Barbiero L, Benussi L, Binetti G
Curr Alzheimer Res. 2004
PubMed ID: 15975068
Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40.
van Dijk R, Fischer DF, Sluijs JA, Sonnemans MA, Hobo B, Mercken L, Mann DM, Hol EM, van Leeuwen FW
J Neurochem. 2004
PubMed ID: 15255950
The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor.
Kaneider NC, Lindner J, Feistritzer C, Sturn DH, Mosheimer BA, Djanani AM, Wiedermann CJ
FASEB J. 2004
PubMed ID: 15208267
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK
FASEB J. 2004
PubMed ID: 15208260
Regional cerebral blood volume reduction in transgenic mutant APP (V717F, K670N/M671L) mice.
Wu EX, Tang H, Asai T, Yan SD
Neurosci Lett. 2004
PubMed ID: 15246553
Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.
Tong L, Balazs R, Thornton PL, Cotman CW
J Neurosci. 2004
PubMed ID: 15282285
Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP.
Recuero M, Serrano E, Bullido MJ, Valdivieso F
FEBS Lett. 2004
PubMed ID: 15251450
Secretion of long Abeta-related peptides processed at epsilon-cleavage site is dependent on the alpha-secretase pre-cutting.
Kametani F
FEBS Lett. 2004
PubMed ID: 15251442
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G
J Biol Chem. 2004
PubMed ID: 15126508
Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.
Rossner S, Fuchsbrunner K, Lange-Dohna C, Hartlage-Rübsamen M, Bigl V, Betz A, Reim K, Brose N
J Biol Chem. 2004
PubMed ID: 15123597
Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein.
Lanni C, Mazzucchelli M, Porrello E, Govoni S, Racchi M
Eur J Biochem. 2004
PubMed ID: 15233804
Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.
Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K
J Neurol Neurosurg Psychiatry. 2004
PubMed ID: 15201367
Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile.
Dedeoglu A, Choi JK, Cormier K, Kowall NW, Jenkins BG
Brain Res. 2004
PubMed ID: 15158161
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
Pitsi D, Octave JN
J Biol Chem. 2004
PubMed ID: 15087467
Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.
Zhou D, Noviello C, D'Ambrosio C, Scaloni A, D'Adamio L
J Biol Chem. 2004
PubMed ID: 15054097
Influence of the amyloid precursor protein locus on dementia in Down syndrome.
Margallo-Lana M, Morris CM, Gibson AM, Tan AL, Kay DW, Tyrer SP, Moore BP, Ballard CG
Neurology. 2004
PubMed ID: 15184603
Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation.
Taru H, Yoshikawa K, Suzuki T
FEBS Lett. 2004
PubMed ID: 15178331
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.
Cao X, Südhof TC
J Biol Chem. 2004
PubMed ID: 15044485
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T
J Biol Chem. 2004
PubMed ID: 15037614
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
Allinson TM, Parkin ET, Condon TP, Schwager SL, Sturrock ED, Turner AJ, Hooper NM
Eur J Biochem. 2004
PubMed ID: 15182369
Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss.
Reyes AE, Chacón MA, Dinamarca MC, Cerpa W, Morgan C, Inestrosa NC
Am J Pathol. 2004
PubMed ID: 15161650
Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.
Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T
FASEB J. 2004
PubMed ID: 15084524
Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G, Groth D, Mathews PM, St George-Hyslop P, Fraser PE, Ramabhadran TV, Kwok JB, Schofield PR, Carter T, Gandy S, Martins RN
Mol Psychiatry. 2004
PubMed ID: 14993906
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein.
Taru H, Suzuki T
J Biol Chem. 2004
PubMed ID: 14970211
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, Tsujimoto Y, Tohyama M
J Cell Biol. 2004
PubMed ID: 15123740
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor.
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE
J Biol Chem. 2004
PubMed ID: 14985348
Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene.
Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J
J Biol Chem. 2004
PubMed ID: 14985339
Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition.
Bowen RL, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS
J Biol Chem. 2004
PubMed ID: 14871891
Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice.
Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T
J Neuropathol Exp Neurol. 2004
PubMed ID: 15198121
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K
Eur J Neurosci. 2004
PubMed ID: 15147316
Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.
Caillé I, Allinquant B, Dupont E, Bouillot C, Langer A, Müller U, Prochiantz A
Development. 2004
PubMed ID: 15073156
Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques.
Syme CD, Nadal RC, Rigby SE, Viles JH
J Biol Chem. 2004
PubMed ID: 14978032
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H
Science. 2004
PubMed ID: 15087549
CD36 overexpression in human brain correlates with beta-amyloid deposition but not with Alzheimer's disease.
Ricciarelli R, D'Abramo C, Zingg JM, Giliberto L, Markesbery W, Azzi A, Marinari UM, Pronzato MA, Tabaton M
Free Radic Biol Med. 2004
PubMed ID: 15059642
Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease.
Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI
J Biol Chem. 2004
PubMed ID: 14724276
Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats.
Badan I, Dinca I, Buchhold B, Suofu Y, Walker L, Gratz M, Platt D, Kessler CH, Popa-Wagner A
Eur J Neurosci. 2004
PubMed ID: 15090053
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Overexpression of receptor of advanced glycation end products hypersensitizes cells for amyloid beta peptide-induced cell death.
Hadding A, Kaltschmidt B, Kaltschmidt C
Biochim Biophys Acta. 2004
PubMed ID: 15053925
Decreased level of brain acetylcholine and memory disturbance in APPsw mice.
Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Maruyama Y, Shoji M
Neurobiol Aging. 2004
PubMed ID: 15013569
Amyloid precursor protein mRNA levels in Alzheimer's disease brain.
Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ
Brain Res Mol Brain Res. 2004
PubMed ID: 14992810
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.
Li Q, Südhof TC
J Biol Chem. 2004
PubMed ID: 14699153
Optimum amyloid fibril formation of a peptide fragment suggests the amyloidogenic preference of beta2-microglobulin under physiological conditions.
Ohhashi Y, Hasegawa K, Naiki H, Goto Y
J Biol Chem. 2004
PubMed ID: 14699107
A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment.
Muresan Z, Muresan V
Hum Mol Genet. 2004
PubMed ID: 14722157
Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi.
Park HJ, Seong YM, Choi JY, Kang S, Rhim H
Neurosci Lett. 2004
PubMed ID: 15036614
Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.
Ho A, Südhof TC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14983046
The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.
Ghersi E, Vito P, Lopez P, Abdallah M, D'Adamio L
J Alzheimers Dis. 2004
PubMed ID: 15004329
X11alpha impairs gamma- but not beta-cleavage of amyloid precursor protein.
King GD, Cherian K, Turner RS
J Neurochem. 2004
PubMed ID: 14756819
Endoplasmic reticulum-localized amyloid beta-peptide is degraded in the cytosol by two distinct degradation pathways.
Schmitz A, Schneider A, Kummer MP, Herzog V
Traffic. 2004
PubMed ID: 14690498
Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis.
Williams AD, Portelius E, Kheterpal I, Guo JT, Cook KD, Xu Y, Wetzel R
J Mol Biol. 2004
PubMed ID: 14687578
Solid state NMR reveals a pH-dependent antiparallel beta-sheet registry in fibrils formed by a beta-amyloid peptide.
Petkova AT, Buntkowsky G, Dyda F, Leapman RD, Yau WM, Tycko R
J Mol Biol. 2004
PubMed ID: 14659754
Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice.
Hartmann J, Erb C, Ebert U, Baumann KH, Popp A, König G, Klein J
Neuroscience. 2004
PubMed ID: 15120860
The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation.
Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B
Neuroscience. 2004
PubMed ID: 15099690
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia.
Guillemin GJ, Smythe GA, Veas LA, Takikawa O, Brew BJ
Neuroreport. 2003
PubMed ID: 14663182
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
Chang Y, Tesco G, Jeong WJ, Lindsley L, Eckman EA, Eckman CB, Tanzi RE, Guénette SY
J Biol Chem. 2003
PubMed ID: 14527950
Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface.
Chyung JH, Selkoe DJ
J Biol Chem. 2003
PubMed ID: 14525989
Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity.
Qin W, Ho L, Pompl PN, Peng Y, Zhao Z, Xiang Z, Robakis NK, Shioi J, Suh J, Pasinetti GM
J Biol Chem. 2003
PubMed ID: 14507922
Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity.
Suen KC, Yu MS, So KF, Chang RC, Hugon J
J Biol Chem. 2003
PubMed ID: 12975376
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism.
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T
J Biol Chem. 2003
PubMed ID: 12972431
A proximal gene promoter region for the beta-amyloid precursor protein provides a link between development, apoptosis, and Alzheimer's disease.
Lahiri DK, Ghosh C, Ge YW
Ann N Y Acad Sci. 2003
PubMed ID: 15033805
Mutations in presenilin 1, presenilin 2 and amyloid precursor protein genes in patients with early-onset Alzheimer's disease in Poland.
Zekanowski C, Styczyńska M, Pepłońska B, Gabryelewicz T, Religa D, Ilkowski J, Kijanowska-Haładyna B, Kotapka-Minc S, Mikkelsen S, Pfeffer A, Barczak A, Łuczywek E, Wasiak B, Chodakowska-Zebrowska M, Gustaw K, Łaczkowski J, Sobów T, Kuźnicki J, Barcikowska M
Exp Neurol. 2003
PubMed ID: 14769392
Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study.
Borroni B, Colciaghi F, Caltagirone C, Rozzini L, Broglio L, Cattabeni F, Di Luca M, Padovani A
Arch Neurol. 2003
PubMed ID: 14676049
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT
J Biol Chem. 2003
PubMed ID: 12960155
Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.
Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT
Hum Mol Genet. 2003
PubMed ID: 14506131
Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.
Zhou Y, Su Y, Li B, Liu F, Ryder JW, Wu X, Gonzalez-DeWhitt PA, Gelfanova V, Hale JE, May PC, Paul SM, Ni B
Science. 2003
PubMed ID: 14615541
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T
J Biol Chem. 2003
PubMed ID: 12944403
Androgens modulate beta-amyloid levels in male rat brain.
Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ
J Neurochem. 2003
PubMed ID: 14622134
Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease.
Ling Y, Morgan K, Kalsheker N
Int J Biochem Cell Biol. 2003
PubMed ID: 12824062
Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation.
Barnham KJ, Ciccotosto GD, Tickler AK, Ali FE, Smith DG, Williamson NA, Lam YH, Carrington D, Tew D, Kocak G, Volitakis I, Separovic F, Barrow CJ, Wade JD, Masters CL, Cherny RA, Curtain CC, Bush AI, Cappai R
J Biol Chem. 2003
PubMed ID: 12925530
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Kim JY, Kim H, Lee SG, Choi BH, Kim YH, Huh PW, Lee KH, Han H, Rha HK
Biochem Biophys Res Commun. 2003
PubMed ID: 14550290
Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.
Scheinfeld MH, Ghersi E, Davies P, D'Adamio L
J Biol Chem. 2003
PubMed ID: 12917434
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
Kinoshita A, Shah T, Tangredi MM, Strickland DK, Hyman BT
J Biol Chem. 2003
PubMed ID: 12888553
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL
J Cell Biol. 2003
PubMed ID: 14557245
Frameshifted beta-amyloid precursor protein (APP+1) is a secretory protein, and the level of APP+1 in cerebrospinal fluid is linked to Alzheimer pathology.
Hol EM, van Dijk R, Gerez L, Sluijs JA, Hobo B, Tonk MT, de Haan A, Kamphorst W, Fischer DF, Benne R, van Leeuwen FW
J Biol Chem. 2003
PubMed ID: 12900421
Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.
Matsuda S, Matsuda Y, D'Adamio L
J Biol Chem. 2003
PubMed ID: 12893827
A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.
Mousseau DD, Chapelsky S, De Crescenzo G, Kirkitadze MD, Magoon J, Inoue S, Teplow DB, O'Connor-McCourt MD
J Biol Chem. 2003
PubMed ID: 12867422
CSF-tau, CSF-Abeta1-42, ApoE-genotype and clinical parameters in the diagnosis of Alzheimer's disease: combination of CSF-tau and MMSE yields highest sensitivity and specificity.
Ganzer S, Arlt S, Schoder V, Buhmann C, Mandelkow EM, Finckh U, Beisiegel U, Naber D, Müller-Thomsen T
J Neural Transm. 2003
PubMed ID: 14523627
Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms.
Hiruma H, Katakura T, Takahashi S, Ichikawa T, Kawakami T
J Neurosci. 2003
PubMed ID: 14523099
The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis.
Kögel D, Schomburg R, Schürmann T, Reimertz C, König HG, Poppe M, Eckert A, Müller WE, Prehn JH
J Neurochem. 2003
PubMed ID: 12969271
Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.
Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT
J Mol Biol. 2003
PubMed ID: 12972252
Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.
Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I
J Neurosci. 2003
PubMed ID: 13679420
Both raft- and non-raft proteins associate with CHAPS-insoluble complexes: some APP in large complexes.
Rouvinski A, Gahali-Sass I, Stav I, Metzer E, Atlan H, Taraboulos A
Biochem Biophys Res Commun. 2003
PubMed ID: 12927782
Folding and stability of the extracellular domain of the human amyloid precursor protein.
Botelho MG, Gralle M, Oliveira CL, Torriani I, Ferreira ST
J Biol Chem. 2003
PubMed ID: 12796495
sAPP as a regulator of dendrite motility and melanin release in epidermal melanocytes and melanoma cells.
Quast T, Wehner S, Kirfel G, Jaeger K, De Luca M, Herzog V
FASEB J. 2003
PubMed ID: 12958194
Y10W beta(1-40) fluorescence reflects epitope exposure in conformers of Alzheimer's beta-peptide.
LeVine H
Arch Biochem Biophys. 2003
PubMed ID: 12921787
Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein.
Noviello C, Vito P, Lopez P, Abdallah M, D'Adamio L
J Biol Chem. 2003
PubMed ID: 12805363
XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.
Sumioka A, Imoto S, Martins RN, Kirino Y, Suzuki T
Biochem J. 2003
PubMed ID: 12780348
Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors.
Magklara A, Mellati AA, Wasney GA, Little SP, Sotiropoulou G, Becker GW, Diamandis EP
Biochem Biophys Res Commun. 2003
PubMed ID: 12878203
A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease.
Ezquerra M, Lleó A, Castellví M, Queralt R, Santacruz P, Pastor P, Molinuevo JL, Blesa R, Oliva R
Arch Neurol. 2003
PubMed ID: 12925374
DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3.
McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL
J Neurosci. 2003
PubMed ID: 12890786
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.
Cataldo AM, Petanceska S, Peterhoff CM, Terio NB, Epstein CJ, Villar A, Carlson EJ, Staufenbiel M, Nixon RA
J Neurosci. 2003
PubMed ID: 12890772
Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.
Dougherty JJ, Wu J, Nichols RA
J Neurosci. 2003
PubMed ID: 12890766
Expression of liver X receptor target genes decreases cellular amyloid beta peptide secretion.
Sun Y, Yao J, Kim TW, Tall AR
J Biol Chem. 2003
PubMed ID: 12754201
Activation of the c-Jun N-terminal kinase signaling cascade mediates the effect of amyloid-beta on long term potentiation and cell death in hippocampus: a role for interleukin-1beta?
Minogue AM, Schmid AW, Fogarty MP, Moore AC, Campbell VA, Herron CE, Lynch MA
J Biol Chem. 2003
PubMed ID: 12738769
Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway.
Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A
J Biol Chem. 2003
PubMed ID: 12730216
Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD.
Masliah E, Alford M, Adame A, Rockenstein E, Galasko D, Salmon D, Hansen LA, Thal LJ
Neurology. 2003
PubMed ID: 12874400
Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ
J Biol Chem. 2003
PubMed ID: 12736250
Glycation of the amyloid beta-protein by a nicotine metabolite: a fortuitous chemical dynamic between smoking and Alzheimer's disease.
Dickerson TJ, Janda KD
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12815102
Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.
Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K
J Neurosci. 2003
PubMed ID: 12843267
Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.
Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N
Eur J Neurosci. 2003
PubMed ID: 12859342
Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.
Wang X, Le Roy I, Nicodeme E, Li R, Wagner R, Petros C, Churchill GA, Harris S, Darvasi A, Kirilovsky J, Roubertoux PL, Paigen B
Genome Res. 2003
PubMed ID: 12805272
APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations.
Bergman A, Religa D, Karlström H, Laudon H, Winblad B, Lannfelt L, Lundkvist J, Näslund J
Exp Cell Res. 2003
PubMed ID: 12799176
Learning and memory deficits in APP transgenic mouse models of amyloid deposition.
Morgan D
Neurochem Res. 2003
PubMed ID: 12737527
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.
Yoshiike Y, Chui DH, Akagi T, Tanaka N, Takashima A
J Biol Chem. 2003
PubMed ID: 12716908
Upregulation and antiapoptotic role of endogenous Alzheimer amyloid precursor protein in dorsal root ganglion neurons.
Nishimura I, Takazaki R, Kuwako K, Enokido Y, Yoshikawa K
Exp Cell Res. 2003
PubMed ID: 12749853
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K
Biochem Biophys Res Commun. 2003
PubMed ID: 12763021
Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population.
Clarimón J, Bertranpetit J, Calafell F, Boada M, Tàrraga L, Comas D
Psychiatr Genet. 2003
PubMed ID: 12782964
Downregulation and increased turnover of beta-amyloid precursor protein in skeletal muscle cultures by neuregulin-1.
Rosen KM, Ford BD, Querfurth HW
Exp Neurol. 2003
PubMed ID: 12781990
Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.
Lesné S, Docagne F, Gabriel C, Liot G, Lahiri DK, Buée L, Plawinski L, Delacourte A, MacKenzie ET, Buisson A, Vivien D
J Biol Chem. 2003
PubMed ID: 12626500
Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12732730
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, Beyreuther K, Masters CL, Parker MW, Cappai R
J Biol Chem. 2003
PubMed ID: 12611883
Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Abeta(1-40).
Zou P, Ding Y, Sha Y, Hu B, Nie S
Peptides. 2003
PubMed ID: 12895653
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J
Nat Biotechnol. 2003
PubMed ID: 12665801
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG
Science. 2003
PubMed ID: 12702875
Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.
Higashi S, Miyazaki K
J Biol Chem. 2003
PubMed ID: 12586836
Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria.
Wang B, Nguyen M, Breckenridge DG, Stojanovic M, Clemons PA, Kuppig S, Shore GC
J Biol Chem. 2003
PubMed ID: 12529377
Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.
Reilly JF, Games D, Rydel RE, Freedman S, Schenk D, Young WG, Morrison JH, Bloom FE
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12697936
Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes.
Kakio A, Nishimoto S, Kozutsumi Y, Matsuzaki K
Biochem Biophys Res Commun. 2003
PubMed ID: 12659848
Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development.
Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A
Anat Embryol (Berl). 2003
PubMed ID: 12684764
The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway.
Zhao Q, Lee FS
Biochemistry. 2003
PubMed ID: 12653567
Enhanced production of amyloid precursor protein mRNA by peripheral mononuclear blood cell in Alzheimer's disease.
Jiang S, Zhang M, Ren D, Tang G, Lin S, Qian Y, Zhang Y, Jiang K, Li F, Wang D
Am J Med Genet B Neuropsychiatr Genet. 2003
PubMed ID: 12627474
beta-Amyloid-specific upregulation of stearoyl coenzyme A desaturase-1 in macrophages.
Uryu S, Tokuhiro S, Oda T
Biochem Biophys Res Commun. 2003
PubMed ID: 12646202
APP processing and synaptic function.
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R
Neuron. 2003
PubMed ID: 12670422
Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation.
Greenberg SM, Shin Y, Grabowski TJ, Cooper GE, Rebeck GW, Iglesias S, Chapon F, Tournier-Lasserve E, Baron JC
Neurology. 2003
PubMed ID: 12654973
Late Simian virus 40 transcription factor is a target of the phosphoinositide 3-kinase/Akt pathway in anti-apoptotic Alzheimer's amyloid precursor protein signalling.
Kashour T, Burton T, Dibrov A, Amara FM
Biochem J. 2003
PubMed ID: 12472467
Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.
Gianni D, Zambrano N, Bimonte M, Minopoli G, Mercken L, Talamo F, Scaloni A, Russo T
J Biol Chem. 2003
PubMed ID: 12645527
Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Ikeuchi T, Dolios G, Kim SH, Wang R, Sisodia SS
J Biol Chem. 2003
PubMed ID: 12493731
Change and stabilization of the amyloid-beta(1-40) secondary structure by fluorocompounds.
Vieira EP, Hermel H, Möhwald H
Biochim Biophys Acta. 2003
PubMed ID: 12535605
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H
J Biol Chem. 2003
PubMed ID: 12435726
Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
Eckman EA, Watson M, Marlow L, Sambamurti K, Eckman CB
J Biol Chem. 2003
PubMed ID: 12464614
Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.
Herms J, Schneider I, Dewachter I, Caluwaerts N, Kretzschmar H, Van Leuven F
J Biol Chem. 2003
PubMed ID: 12431992
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts.
Ehehalt R, Keller P, Haass C, Thiele C, Simons K
J Cell Biol. 2003
PubMed ID: 12515826
Transgenic mice expressing the PS1-A246E mutation: effects on spatial learning, exploration, anxiety, and motor coordination.
Lalonde R, Qian S, Strazielle C
Behav Brain Res. 2003
PubMed ID: 12493631
Beta-amyloid modulates tyrosine kinase B receptor expression in SHSY5Y neuroblastoma cells: influence of the antioxidant melatonin.
Olivieri G, Otten U, Meier F, Baysang G, Dimitriades-Schmutz B, Müller-Spahn F, Savaskan E
Neuroscience. 2003
PubMed ID: 12895507
X11alpha modulates secretory and endocytic trafficking and metabolism of amyloid precursor protein: mutational analysis of the YENPTY sequence.
King GD, Perez RG, Steinhilb ML, Gaut JR, Turner RS
Neuroscience. 2003
PubMed ID: 12849748
Genetic modulation of tau phosphorylation in the mouse.
Brich J, Shie FS, Howell BW, Li R, Tus K, Wakeland EK, Jin LW, Mumby M, Churchill G, Herz J, Cooper JA
J Neurosci. 2003
PubMed ID: 12514215
beta-Amyloid (1-40)-induced apoptosis of cultured cortical neurones involves calpain-mediated cleavage of poly-ADP-ribose polymerase.
Boland B, Campbell V
Neurobiol Aging. 2003
PubMed ID: 12493564
Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele.
Pahnke J, Walker LC, Schroeder E, Vogelgesang S, Stausske D, Walther R, Warzok RW
Acta Neuropathol. 2003
PubMed ID: 12471457
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease.
Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Møller M, Holton J, Frangione B, Ghiso J
J Biol Chem. 2002
PubMed ID: 12388551
A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid.
Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW
J Biol Chem. 2002
PubMed ID: 12239221
A gene expression map of human chromosome 21 orthologues in the mouse.
Gitton Y, Dahmane N, Baik S, Ruiz i Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, HSA21 expression map initiative
Nature. 2002
PubMed ID: 12466855
Human chromosome 21 gene expression atlas in the mouse.
Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A
Nature. 2002
PubMed ID: 12466854
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Impaired eyeblink conditioning and decreased hippocampal volume in PDAPP V717F mice.
Weiss C, Venkatasubramanian PN, Aguado AS, Power JM, Tom BC, Li L, Chen KS, Disterhoft JF, Wyrwicz AM
Neurobiol Dis. 2002
PubMed ID: 12586551
Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats.
Ciallella JR, Ikonomovic MD, Paljug WR, Wilbur YI, Dixon CE, Kochanek PM, Marion DW, DeKosky ST
J Neurotrauma. 2002
PubMed ID: 12542857
Anti-apoptotic wild-type Alzheimer amyloid precursor protein signaling involves the p38 mitogen-activated protein kinase/MEF2 pathway.
Burton TR, Dibrov A, Kashour T, Amara FM
Brain Res Mol Brain Res. 2002
PubMed ID: 12480183
Membrane destabilization induced by beta-amyloid peptide 29-42: importance of the amino-terminus.
Mingeot-Leclercq MP, Lins L, Bensliman M, Van Bambeke F, Van Der Smissen P, Peuvot J, Schanck A, Brasseur R
Chem Phys Lipids. 2002
PubMed ID: 12426076
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice.
Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ
Nat Neurosci. 2002
PubMed ID: 12402041
Spatial learning, exploration, anxiety, and motor coordination in female APP23 transgenic mice with the Swedish mutation.
Lalonde R, Dumont M, Staufenbiel M, Sturchler-Pierrat C, Strazielle C
Brain Res. 2002
PubMed ID: 12426044
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
Cottingham MG, Hollinshead MS, Vaux DJ
Biochemistry. 2002
PubMed ID: 12427014
Enriched early experiences of mice underexpressing the beta-amyloid precursor protein restore spatial learning capabilities but not normal openfield behavior of adult animals.
Tremml P, Lipp HP, Müller U, Wolfer DP
Genes Brain Behav. 2002
PubMed ID: 12882368
Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Russo C, Dolcini V, Salis S, Venezia V, Violani E, Carlo P, Zambrano N, Russo T, Schettini G
Ann N Y Acad Sci. 2002
PubMed ID: 12485888
Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor.
Van Nostrand WE, Melchor JP, Romanov G, Zeigler K, Davis J
Ann N Y Acad Sci. 2002
PubMed ID: 12480759
Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease.
Athan ES, Lee JH, Arriaga A, Mayeux RP, Tycko B
Arch Neurol. 2002
PubMed ID: 12433268
Beta-amyloid 25 to 35 is intercalated in anionic and zwitterionic lipid membranes to different extents.
Dante S, Hauss T, Dencher NA
Biophys J. 2002
PubMed ID: 12414694
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology.
Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK
Am J Pathol. 2002
PubMed ID: 12414533
The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?
Koo EH
Traffic. 2002
PubMed ID: 12383342
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling.
Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12244210
Coordination of copper(II) ions by the 11-20 and 11-28 fragments of human and mouse beta-amyloid peptide.
Kowalik-Jankowska T, Ruta-Dolejsz M, Wiśniewska K, Lankiewicz L
J Inorg Biochem. 2002
PubMed ID: 12230982
Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.
Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P
J Biol Chem. 2002
PubMed ID: 12119298
Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of clapains enhances endosomal generation of beta-cleaved C-terminal APP fragments.
Mathews PM, Jiang Y, Schmidt SD, Grbovic OM, Mercken M, Nixon RA
J Biol Chem. 2002
PubMed ID: 12087104
Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.
Lee M, You HJ, Cho SH, Woo CH, Yoo MH, Joe EH, Kim JH
Biochem J. 2002
PubMed ID: 12038964
Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.
Mohajeri MH, Saini K, Schultz JG, Wollmer MA, Hock C, Nitsch RM
J Biol Chem. 2002
PubMed ID: 12068009
Differential rates of frameshift alterations in four repeat sequences of hereditary nonpolyposis colorectal cancer tumors.
Paoloni-Giacobino A, Rey-Berthod C, Couturier A, Antonarakis SE, Hutter P
Hum Genet. 2002
PubMed ID: 12215842
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms.
Biederer T, Cao X, Südhof TC, Liu X
J Neurosci. 2002
PubMed ID: 12196555
Additive effects of amyloid beta fragment and interleukin-1beta on interleukin-6 secretion in rat primary glial cultures.
Holmlund L, Cortés Toro V, Iverfeldt K
Int J Mol Med. 2002
PubMed ID: 12165795
Assembling amyloid fibrils from designed structures containing a significant amyloid beta-peptide fragment.
Tjernberg LO, Tjernberg A, Bark N, Shi Y, Ruzsicska BP, Bu Z, Thyberg J, Callaway DJ
Biochem J. 2002
PubMed ID: 12023906
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP
Neurology. 2002
PubMed ID: 12177374
The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
Kinoshita A, Whelan CM, Berezovska O, Hyman BT
J Biol Chem. 2002
PubMed ID: 12032152
The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system.
Goto JJ, Tanzi RE
J Mol Neurosci. 2002
PubMed ID: 12212791
Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism.
Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL
J Biol Chem. 2002
PubMed ID: 12016213
Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads.
Burton T, Liang B, Dibrov A, Amara F
Biochem Biophys Res Commun. 2002
PubMed ID: 12099698
Transcriptional activation and increase in expression of Alzheimer's beta-amyloid precursor protein gene is mediated by TGF-beta in normal human astrocytes.
Burton T, Liang B, Dibrov A, Amara F
Biochem Biophys Res Commun. 2002
PubMed ID: 12099697
Neurodegenerative disease: amyloid pores from pathogenic mutations.
Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT
Nature. 2002
PubMed ID: 12124613
Alteration of cortical EEG in mice carrying mutated human APP transgene.
Wang J, Ikonen S, Gurevicius K, van Groen T, Tanila H
Brain Res. 2002
PubMed ID: 12101040
A novel mechanism for the regulation of amyloid precursor protein metabolism.
Chen Q, Kimura H, Schubert D
J Cell Biol. 2002
PubMed ID: 12093789
Evidence for binding of the ectodomain of amyloid precursor protein 695 and activated high molecular weight kininogen.
Das A, Smalheiser NR, Markaryan A, Kaplan A
Biochim Biophys Acta. 2002
PubMed ID: 12090937
Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro.
Zhou Z, Relkin N, Ghiso J, Smith JD, Gandy S
Mol Med. 2002
PubMed ID: 12393935
Intraneuronal APP/A beta trafficking and plaque formation in beta-amyloid precursor protein and presenilin-1 transgenic mice.
Wirths O, Multhaup G, Czech C, Feldmann N, Blanchard V, Tremp G, Beyreuther K, Pradier L, Bayer TA
Brain Pathol. 2002
PubMed ID: 12146796
Annexin 5 and apolipoprotein E2 protect against Alzheimer's amyloid-beta-peptide cytotoxicity by competitive inhibition at a common phosphatidylserine interaction site.
Lee G, Pollard HB, Arispe N
Peptides. 2002
PubMed ID: 12128082
Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice.
Walker LC, Callahan MJ, Bian F, Durham RA, Roher AE, Lipinski WJ
Peptides. 2002
PubMed ID: 12128081
Laminin affects polymerization, depolymerization and neurotoxicity of Abeta peptide.
Morgan C, Bugueño MP, Garrido J, Inestrosa NC
Peptides. 2002
PubMed ID: 12128080
Correlation between beta-amyloid peptide production and human APP-induced neuronal death.
Kienlen-Campard P, Octave JN
Peptides. 2002
PubMed ID: 12128077
Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.
Lütjohann D, Brzezinka A, Barth E, Abramowski D, Staufenbiel M, von Bergmann K, Beyreuther K, Multhaup G, Bayer TA
J Lipid Res. 2002
PubMed ID: 12091492
A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region.
Olson JM, Goddard KA, Dudek DM
Am J Hum Genet. 2002
PubMed ID: 12016588
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms.
Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12070348
Mutations that reduce aggregation of the Alzheimer's Abeta42 peptide: an unbiased search for the sequence determinants of Abeta amyloidogenesis.
Wurth C, Guimard NK, Hecht MH
J Mol Biol. 2002
PubMed ID: 12079364
Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H
J Biol Chem. 2002
PubMed ID: 11912199
Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease.
Doré S
Free Radic Biol Med. 2002
PubMed ID: 12057765
Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells.
Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW
J Biol Chem. 2002
PubMed ID: 11912196
Pathway complexity of prion protein assembly into amyloid.
Baskakov IV, Legname G, Baldwin MA, Prusiner SB, Cohen FE
J Biol Chem. 2002
PubMed ID: 11912192
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12048239
Developmental expression of the beta-amyloid precursor protein and heat-shock protein 70 in the cerebral hemisphere region of the rat brain.
Lahiri DK, Nall C, Chen D, Zaphiriou M, Morgan C, Nurnberger JI
Ann N Y Acad Sci. 2002
PubMed ID: 12105108
Selective nicotinic receptor consequences in APP(SWE) transgenic mice.
Bednar I, Paterson D, Marutle A, Pham TM, Svedberg M, Hellström-Lindahl E, Mousavi M, Court J, Morris C, Perry E, Mohammed A, Zhang X, Nordberg A
Mol Cell Neurosci. 2002
PubMed ID: 12093166
Long time dynamic simulations: exploring the folding pathways of an Alzheimer's amyloid Abeta-peptide.
Straub JE, Guevara J, Huo S, Lee JP
Acc Chem Res. 2002
PubMed ID: 12069633
Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers.
Palmblad M, Westlind-Danielsson A, Bergquist J
J Biol Chem. 2002
PubMed ID: 11912198
Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade.
Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T
J Biol Chem. 2002
PubMed ID: 11912189
An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).
Pasalar P, Najmabadi H, Noorian AR, Moghimi B, Jannati A, Soltanzadeh A, Krefft T, Crook R, Hardy J
Neurology. 2002
PubMed ID: 12034808
The galvanization of beta-amyloid in Alzheimer's disease.
Bush AI, Tanzi RE
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12032279
Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.).
Blanchard BJ, Stockwell BR, Ingram VM
Biochem Biophys Res Commun. 2002
PubMed ID: 12054503
Mechanism of membrane depolarization caused by the Alzheimer Abeta1-42 peptide.
Blanchard BJ, Thomas VL, Ingram VM
Biochem Biophys Res Commun. 2002
PubMed ID: 12054502
Signaling events in amyloid beta-peptide-induced neuronal death and insulin-like growth factor I protection.
Wei W, Wang X, Kusiak JW
J Biol Chem. 2002
PubMed ID: 11882652
The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.
Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12011466
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L
J Biol Chem. 2002
PubMed ID: 11877420
Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.
Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC
Neurosci Res. 2002
PubMed ID: 12074840
Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition.
Fodero LR, Sáez-Valero J, McLean CA, Martins RN, Beyreuther K, Masters CL, Robertson TA, Small DH
J Neurochem. 2002
PubMed ID: 12065653
FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction.
Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW
Neurobiol Aging. 2002
PubMed ID: 11959395
Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.
Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11972038
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ
Neuron. 2002
PubMed ID: 11988176
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).
Edbauer D, Willem M, Lammich S, Steiner H, Haass C
J Biol Chem. 2002
PubMed ID: 11809755
APP knockout attenuates microglial activation and enhances neuron survival in substantia nigra compacta after axotomy.
DeGiorgio LA, Shimizu Y, Chun HS, Cho BP, Sugama S, Joh TH, Volpe BT
Glia. 2002
PubMed ID: 11948811
The amyloid-beta peptide binds to cyclin B1 and increases human cyclin-dependent kinase-1 activity.
Milton NG
Neurosci Lett. 2002
PubMed ID: 11958860
Estrogen lowers Alzheimer beta-amyloid generation by stimulating trans-Golgi network vesicle biogenesis.
Greenfield JP, Leung LW, Cai D, Kaasik K, Gross RS, Rodriguez-Boulan E, Greengard P, Xu H
J Biol Chem. 2002
PubMed ID: 11823458
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo.
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ
Nature. 2002
PubMed ID: 11932745
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T
EMBO J. 2002
PubMed ID: 11927537
Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.
DeMattos RB, Bales KR, Parsadanian M, O'Dell MA, Foss EM, Paul SM, Holtzman DM
J Neurochem. 2002
PubMed ID: 12064470
Role of glycine-33 and methionine-35 in Alzheimer's amyloid beta-peptide 1-42-associated oxidative stress and neurotoxicity.
Kanski J, Varadarajan S, Aksenova M, Butterfield DA
Biochim Biophys Acta. 2002
PubMed ID: 11959460
Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.
Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN
J Neurosci. 2002
PubMed ID: 11896164
Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II.
Rank KB, Pauley AM, Bhattacharya K, Wang Z, Evans DB, Fleck TJ, Johnston JA, Sharma SK
FEBS Lett. 2002
PubMed ID: 11943163
Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling.
Yaar M, Zhai S, Fine RE, Eisenhauer PB, Arble BL, Stewart KB, Gilchrest BA
J Biol Chem. 2002
PubMed ID: 11756426
Expression of c-Fos and c-Myc and deposition of beta-APP in neurons in the adult rat brain as a result of exposure to short-lasting impulse noise.
Säljö A, Bao F, Shi J, Hamberger A, Hansson HA, Haglid KG
J Neurotrauma. 2002
PubMed ID: 11939505
[Interactions between amyloid beta--protein and gangliosides]
Matsuzaki K
Tanpakushitsu Kakusan Koso. 2002
PubMed ID: 11915326
[Pathological implications of GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease]
Yanagisawa K
Tanpakushitsu Kakusan Koso. 2002
PubMed ID: 11915325
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH
J Neurosci. 2002
PubMed ID: 11880515
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome.
Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA
Neuron. 2002
PubMed ID: 11879646
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing.
Weidemann A, Eggert S, Reinhard FB, Vogel M, Paliga K, Baier G, Masters CL, Beyreuther K, Evin G
Biochemistry. 2002
PubMed ID: 11851430
Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.
Huitrón-Reséndiz S, Sánchez-Alavez M, Gallegos R, Berg G, Crawford E, Giacchino JL, Games D, Henriksen SJ, Criado JR
Brain Res. 2002
PubMed ID: 11844479
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
Koistinaho M, Kettunen MI, Goldsteins G, Keinänen R, Salminen A, Ort M, Bures J, Liu D, Kauppinen RA, Higgins LS, Koistinaho J
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11818564
[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients.
Colciaghi F, Borroni B, Pastorino L, Marcello E, Zimmermann M, Cattabeni F, Padovani A, Di Luca M
Mol Med. 2002
PubMed ID: 12080182
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein.
Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C
Neurobiol Dis. 2002
PubMed ID: 11848685
Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice.
Gau JT, Steinhilb ML, Kao TC, D'Amato CJ, Gaut JR, Frey KA, Turner RS
Am J Pathol. 2002
PubMed ID: 11839594
Crystal structure reveals basis for the inhibitor resistance of human brain trypsin.
Katona G, Berglund GI, Hajdu J, Gráf L, Szilágyi L
J Mol Biol. 2002
PubMed ID: 11827488
Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse.
Gordon MN, Holcomb LA, Jantzen PT, DiCarlo G, Wilcock D, Boyett KW, Connor K, Melachrino J, O'Callaghan JP, Morgan D
Exp Neurol. 2002
PubMed ID: 11822882
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, D'Adamio L
J Biol Chem. 2002
PubMed ID: 11724784
Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice.
Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, Walker L, Staufenbiel M, Jucker M
J Neurosci. 2002
PubMed ID: 11784797
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
White AR, Multhaup G, Galatis D, McKinstry WJ, Parker MW, Pipkorn R, Beyreuther K, Masters CL, Cappai R
J Neurosci. 2002
PubMed ID: 11784781
Structure determination of micelle-like intermediates in amyloid beta -protein fibril assembly by using small angle neutron scattering.
Yong W, Lomakin A, Kirkitadze MD, Teplow DB, Chen SH, Benedek GB
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11756677
A cell biological perspective on Alzheimer's disease.
Annaert W, De Strooper B
Annu Rev Cell Dev Biol. 2002
PubMed ID: 12142279
The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties.
Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG
Neuromolecular Med. 2002
PubMed ID: 12025818
Age-dependent differential regulation of genes encoding APP and alpha-synuclein in hippocampal synaptic plasticity.
Stéphan A, Davis S, Salin H, Dumas S, Mallet J, Laroche S
Hippocampus. 2002
PubMed ID: 11918289
Modulation of A(beta) peptides by estrogen in mouse models.
Zheng H, Xu H, Uljon SN, Gross R, Hardy K, Gaynor J, Lafrancois J, Simpkins J, Refolo LM, Petanceska S, Wang R, Duff K
J Neurochem. 2002
PubMed ID: 11796757
Expression of the gene encoding the beta-amyloid precursor protein APP in Xenopus laevis.
van den Hurk WH, Bloemen M, Martens GJ
Brain Res Mol Brain Res. 2001
PubMed ID: 11744158
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.
Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS
Nature. 2001
PubMed ID: 11740561
Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase.
Milton NG
Neuroreport. 2001
PubMed ID: 11726805
Neuropathological characterization of mutant amyloid precursor protein yeast artificial chromosome transgenic mice.
Kulnane LS, Lamb BT
Neurobiol Dis. 2001
PubMed ID: 11741394
Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.
Yazawa H, Yu ZX, Takeda, Le Y, Gong W, Ferrans VJ, Oppenheim JJ, Li CC, Wang JM
FASEB J. 2001
PubMed ID: 11689470
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.
Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM
J Neurosci. 2001
PubMed ID: 11606625
Activation of complement and contact system in Alzheimer's disease.
Bergamaschini L, Donarini C, Gobbo G, Parnetti L, Gallai V
Mech Ageing Dev. 2001
PubMed ID: 11589915
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ
J Biol Chem. 2001
PubMed ID: 11544248
Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid.
Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T
J Biol Chem. 2001
PubMed ID: 11517218
beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11572944
Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis.
Kirkitadze MD, Condron MM, Teplow DB
J Mol Biol. 2001
PubMed ID: 11580253
Appican, the proteoglycan form of the amyloid precursor protein, contains chondroitin sulfate E in the repeating disaccharide region and 4-O-sulfated galactose in the linkage region.
Tsuchida K, Shioi J, Yamada S, Boghosian G, Wu A, Cai H, Sugahara K, Robakis NK
J Biol Chem. 2001
PubMed ID: 11479316
Systematic genetic study of Alzheimer disease in Latin America: mutation frequencies of the amyloid beta precursor protein and presenilin genes in Colombia.
Arango D, Cruts M, Torres O, Backhovens H, Serrano ML, Villareal E, Montañes P, Matallana D, Cano C, Van Broeckhoven C, Jacquier M
Am J Med Genet. 2001
PubMed ID: 11568920
The amyloid precursor protein locus and very-late-onset Alzheimer disease.
Olson JM, Goddard KA, Dudek DM
Am J Hum Genet. 2001
PubMed ID: 11500807
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch.
Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y
J Biol Chem. 2001
PubMed ID: 11483588
Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice.
Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS
J Neurosci. 2001
PubMed ID: 11549719
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology.
Lüth HJ, Holzer M, Gärtner U, Staufenbiel M, Arendt T
Brain Res. 2001
PubMed ID: 11532247
APP processing and synaptic plasticity in presenilin-1 conditional knockout mice.
Yu H, Saura CA, Choi SY, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J
Neuron. 2001
PubMed ID: 11567612
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.
Scheuermann S, Hambsch B, Hesse L, Stumm J, Schmidt C, Beher D, Bayer TA, Beyreuther K, Multhaup G
J Biol Chem. 2001
PubMed ID: 11438549
BACE2 functions as an alternative alpha-secretase in cells.
Yan R, Munzner JB, Shuck ME, Bienkowski MJ
J Biol Chem. 2001
PubMed ID: 11423558
The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture.
Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B
J Neurochem. 2001
PubMed ID: 11553691
The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L
Nat Neurosci. 2001
PubMed ID: 11528419
Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes.
Kurt MA, Davies DC, Kidd M, Duff K, Rolph SC, Jennings KH, Howlett DR
Exp Neurol. 2001
PubMed ID: 11520121
CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease.
Blennow K, Vanmechelen E, Hampel H
Mol Neurobiol. 2001
PubMed ID: 11831556
Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins.
Kontush A
Cell Mol Neurobiol. 2001
PubMed ID: 11775062
Increased cystatin C in astrocytes of transgenic mice expressing the K670N-M671L mutation of the amyloid precursor protein and deposition in brain amyloid plaques.
Steinhoff T, Moritz E, Wollmer MA, Mohajeri MH, Kins S, Nitsch RM
Neurobiol Dis. 2001
PubMed ID: 11493029
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.
Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K
Neurobiol Dis. 2001
PubMed ID: 11493021
Immunization with a nontoxic/nonfibrillar amyloid-beta homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice.
Sigurdsson EM, Scholtzova H, Mehta PD, Frangione B, Wisniewski T
Am J Pathol. 2001
PubMed ID: 11485902
Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ
Exp Neurol. 2001
PubMed ID: 11476589
Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB).
Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D
Brain Res. 2001
PubMed ID: 11430884
A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.
Ott MO, Bullock SL
Dev Genes Evol. 2001
PubMed ID: 11466532
Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.
Fitzjohn SM, Morton RA, Kuenzi F, Rosahl TW, Shearman M, Lewis H, Smith D, Reynolds DS, Davies CH, Collingridge GL, Seabrook GR
J Neurosci. 2001
PubMed ID: 11425896
Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D
J Biol Chem. 2001
PubMed ID: 11279122
Entactin-induced inhibition of human amyloid beta-protein fibril formation in vitro.
Kiuchi Y, Isobe Y, Fukushima K
Neurosci Lett. 2001
PubMed ID: 11376898
The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M, Russo T
J Biol Chem. 2001
PubMed ID: 11279131
Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits.
Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ
J Biol Chem. 2001
PubMed ID: 11274207
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA, Barnham KJ, Volitakis I, Fraser FW, Kim Y, Huang X, Goldstein LE, Moir RD, Lim JT, Beyreuther K, Zheng H, Tanzi RE, Masters CL, Bush AI
Neuron. 2001
PubMed ID: 11430801
Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy.
Grabowski TJ, Cho HS, Vonsattel JP, Rebeck GW, Greenberg SM
Ann Neurol. 2001
PubMed ID: 11409420
beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.
Kajkowski EM, Lo CF, Ning X, Walker S, Sofia HJ, Wang W, Edris W, Chanda P, Wagner E, Vile S, Ryan K, McHendry-Rinde B, Smith SC, Wood A, Rhodes KJ, Kennedy JD, Bard J, Jacobsen JS, Ozenberger BA
J Biol Chem. 2001
PubMed ID: 11278849
Cysteine 73 in bleomycin hydrolase is critical for amyloid precursor protein processing.
Lefterov IM, Koldamova RP, Lefterova MI, Schwartz DR, Lazo JS
Biochem Biophys Res Commun. 2001
PubMed ID: 11350084
Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein.
Johnson RJ, Xiao G, Shanmugaratnam J, Fine RE
Neurobiol Aging. 2001
PubMed ID: 11378243
Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry.
Han X, Holtzman DM, McKeel DW
J Neurochem. 2001
PubMed ID: 11359882
TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.
Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L
Nat Med. 2001
PubMed ID: 11329064
In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.
Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB
Biochem J. 2001
PubMed ID: 11311152
Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains.
Kuo YM, Kokjohn TA, Beach TG, Sue LI, Brune D, Lopez JC, Kalback WM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Roher AE
J Biol Chem. 2001
PubMed ID: 11152675
Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.
Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K
Am J Pathol. 2001
PubMed ID: 11290552
Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo.
Meng JY, Kataoka H, Itoh H, Koono M
Int J Cancer. 2001
PubMed ID: 11279603
Beta-amyloid plaques induce neuritic dystrophy of nitric oxide-producing neurons in a transgenic mouse model of Alzheimer's disease.
Quinn J, Davis F, Woodward WR, Eckenstein F
Exp Neurol. 2001
PubMed ID: 11259108
Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity.
Koldamova RP, Lefterov IM, Lefterova MI, Lazo JS
Biochemistry. 2001
PubMed ID: 11297421
Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology.
Apelt J, Schliebs R
Brain Res. 2001
PubMed ID: 11245811
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation.
Minopoli G, de Candia P, Bonetti A, Faraonio R, Zambrano N, Russo T
J Biol Chem. 2001
PubMed ID: 11085987
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.
Ohsawa I, Takamura C, Kohsaka S
J Neurochem. 2001
PubMed ID: 11238726
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
Christie R, Yamada M, Moskowitz M, Hyman B
Am J Pathol. 2001
PubMed ID: 11238054
Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy.
Winkler DT, Bondolfi L, Herzig MC, Jann L, Calhoun ME, Wiederhold KH, Tolnay M, Staufenbiel M, Jucker M
J Neurosci. 2001
PubMed ID: 11222652
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.
Morris SM, Cooper JA
Traffic. 2001
PubMed ID: 11247302
Molecular phylogenetics and the origins of placental mammals.
Murphy WJ, Eizirik E, Johnson WE, Zhang YP, Ryder OA, O'Brien SJ
Nature. 2001
PubMed ID: 11214319
Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.
Cha JH, Farrell LA, Ahmed SF, Frey A, Hsiao-Ashe KK, Young AB, Penney JB, Locascio JJ, Hyman BT, Irizarry MC
Neurobiol Dis. 2001
PubMed ID: 11162243
Ts65Dn -- localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome.
Akeson EC, Lambert JP, Narayanswami S, Gardiner K, Bechtel LJ, Davisson MT
Cytogenet Cell Genet. 2001
PubMed ID: 11528125
Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8).
Kumar VB, Vyas K, Franko M, Choudhary V, Buddhiraju C, Alvarez J, Morley JE
Biochem Cell Biol. 2001
PubMed ID: 11235921
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).
Standen CL, Brownlees J, Grierson AJ, Kesavapany S, Lau KF, McLoughlin DM, Miller CC
J Neurochem. 2001
PubMed ID: 11146006
beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging.
Irizarry MC, Locascio JJ, Hyman BT
Am J Pathol. 2001
PubMed ID: 11141490
Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice.
Bornemann KD, Wiederhold KH, Pauli C, Ermini F, Stalder M, Schnell L, Sommer B, Jucker M, Staufenbiel M
Am J Pathol. 2001
PubMed ID: 11141480
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.
Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG
Nature. 2000
PubMed ID: 11140684
Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice.
Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E
Am J Pathol. 2000
PubMed ID: 11106573
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG
J Neurosci. 2000
PubMed ID: 11102478
Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands.
Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, Moir RD, Nath A, He JJ
Nat Med. 2000
PubMed ID: 11100124
Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.
Passer B, Pellegrini L, Russo C, Siegel RM, Lenardo MJ, Schettini G, Bachmann M, Tabaton M, D'Adamio L
J Alzheimers Dis. 2000
PubMed ID: 12214090
Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS
Neuron. 2000
PubMed ID: 11144355
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C
Hum Mol Genet. 2000
PubMed ID: 11063718
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rülicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Müller U
J Neurosci. 2000
PubMed ID: 11050115
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain.
Marcinkiewicz M, Seidah NG
J Neurochem. 2000
PubMed ID: 11032903
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P
Nature. 2000
PubMed ID: 10993067
Modeling Alzheimer's disease in transgenic mice: effect of age and of presenilin1 on amyloid biochemistry and pathology in APP/London mice.
Dewachter I, van Dorpe J, Spittaels K, Tesseur I, Van Den Haute C, Moechars D, Van Leuven F
Exp Gerontol. 2000
PubMed ID: 11053674
Expression of macrophage colony-stimulating factor receptor is increased in the AbetaPP(V717F) transgenic mouse model of Alzheimer's disease.
Murphy GM, Zhao F, Yang L, Cordell B
Am J Pathol. 2000
PubMed ID: 10980129
Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.
Lefterov IM, Koldamova RP, Lazo JS
FASEB J. 2000
PubMed ID: 10973933
Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuipéri C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, Van Leuven F
J Neurosci. 2000
PubMed ID: 10964951
Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.
Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T
J Neurochem. 2000
PubMed ID: 10936190
Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
Miravalle L, Tokuda T, Chiarle R, Giaccone G, Bugiani O, Tagliavini F, Frangione B, Ghiso J
J Biol Chem. 2000
PubMed ID: 10821838
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis.
Nakagawa T, Yuan J
J Cell Biol. 2000
PubMed ID: 10953012
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10931940
Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.
Walter J, Schindzielorz A, Hartung B, Haass C
J Biol Chem. 2000
PubMed ID: 10806211
Accumulation of amyloid-beta protein in exocrine glands of transgenic mice overexpressing a carboxyl terminal portion of amyloid protein precursor.
Fukuchi K, Li L, Hart M, Lindsey JR
Int J Exp Pathol. 2000
PubMed ID: 10971744
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA
Neurobiol Dis. 2000
PubMed ID: 10964604
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.
Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922078
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture.
Bruno V, Copani A, Besong G, Scoto G, Nicoletti F
Eur J Pharmacol. 2000
PubMed ID: 10884510
Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.
Verdile G, Martins RN, Duthie M, Holmes E, St George-Hyslop PH, Fraser PE
J Biol Chem. 2000
PubMed ID: 10801777
Chelation and intercalation: complementary properties in a compound for the treatment of Alzheimer's disease.
Cherny RA, Barnham KJ, Lynch T, Volitakis I, Li QX, McLean CA, Multhaup G, Beyreuther K, Tanzi RE, Masters CL, Bush AI
J Struct Biol. 2000
PubMed ID: 10940226
Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F).
Poulsen SA, Watson AA, Fairlie DP, Craik DJ
J Struct Biol. 2000
PubMed ID: 10940222
The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
Zhang S, Iwata K, Lachenmann MJ, Peng JW, Li S, Stimson ER, Lu Y, Felix AM, Maggio JE, Lee JP
J Struct Biol. 2000
PubMed ID: 10940221
Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene.
Murrell JR, Hake AM, Quaid KA, Farlow MR, Ghetti B
Arch Neurol. 2000
PubMed ID: 10867787
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation.
Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L
J Neurosci. 2000
PubMed ID: 10818140
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides.
Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J
Biochem J. 2000
PubMed ID: 10816430
The DNA sequence of human chromosome 21.
Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML, Chromosome 21 mapping and sequencing consortium
Nature. 2000
PubMed ID: 10830953
Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice.
Kane MD, Lipinski WJ, Callahan MJ, Bian F, Durham RA, Schwarz RD, Roher AE, Walker LC
J Neurosci. 2000
PubMed ID: 10804202
A yeast genetic assay for caspase cleavage of the amyloid-beta precursor protein.
Gunyuzlu PL, White WH, Davis GL, Hollis GF, Toyn JH
Mol Biotechnol. 2000
PubMed ID: 10911620
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA
Nat Neurosci. 2000
PubMed ID: 10769385
Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice.
Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S
J Pathol. 2000
PubMed ID: 10767725
Dissection of behavior and psychiatric disorders using the mouse as a model.
Tarantino LM, Bucan M
Hum Mol Genet. 2000
PubMed ID: 10767319
Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle.
Akaaboune M, Allinquant B, Farza H, Roy K, Magoul R, Fiszman M, Festoff BW, Hantaï D
Mol Cell Neurosci. 2000
PubMed ID: 10845772
Mechanisms of cerebrovascular amyloid deposition. Lessons from mouse models.
Burgermeister P, Calhoun ME, Winkler DT, Jucker M
Ann N Y Acad Sci. 2000
PubMed ID: 10818520
Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.
Dodart JC, Mathis C, Saura J, Bales KR, Paul SM, Ungerer A
Neurobiol Dis. 2000
PubMed ID: 10783292
A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor.
Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE
Nat Med. 2000
PubMed ID: 10742146
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB
J Biol Chem. 2000
PubMed ID: 10681545
Alzheimer disease: mouse models pave the way for therapeutic opportunities.
Emilien G, Maloteaux JM, Beyreuther K, Masters CL
Arch Neurol. 2000
PubMed ID: 10681074
Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.
Kumar-Singh S, Dewachter I, Moechars D, Lübke U, De Jonghe C, Ceuterick C, Checler F, Naidu A, Cordell B, Cras P, Van Broeckhoven C, Van Leuven F
Neurobiol Dis. 2000
PubMed ID: 10671319
Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis.
Kwok JB, Li QX, Hallupp M, Whyte S, Ames D, Beyreuther K, Masters CL, Schofield PR
Ann Neurol. 2000
PubMed ID: 10665499
Identification of cis-elements regulating exon 15 splicing of the amyloid precursor protein pre-mRNA.
Bergsdorf C, Paliga K, Kreger S, Masters CL, Beyreuther K
J Biol Chem. 2000
PubMed ID: 10636908
Cloning and characterization of Hunk, a novel mammalian SNF1-related protein kinase.
Gardner HP, Wertheim GB, Ha SI, Copeland NG, Gilbert DJ, Jenkins NA, Marquis ST, Chodosh LA
Genomics. 2000
PubMed ID: 10662544
High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.
Finckh U, Müller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Hock C, Nitsch RM, Gal A
Am J Hum Genet. 2000
PubMed ID: 10631141
Overexpression of the neuritotrophic cytokine S100beta precedes the appearance of neuritic beta-amyloid plaques in APPV717F mice.
Sheng JG, Mrak RE, Bales KR, Cordell B, Paul SM, Jones RA, Woodward S, Zhou XQ, McGinness JM, Griffin WS
J Neurochem. 2000
PubMed ID: 10617132
Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Bales KR, Verina T, Cummins DJ, Du Y, Dodel RC, Saura J, Fishman CE, DeLong CA, Piccardo P, Petegnief V, Ghetti B, Paul SM
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10611368
Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F beta-amyloid precursor protein.
Dodart JC, Mathis C, Bales KR, Paul SM, Ungerer A
Neurosci Lett. 1999
PubMed ID: 10643895
Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM
J Biol Chem. 1999
PubMed ID: 10593990
Amyloid-beta binds catalase with high affinity and inhibits hydrogen peroxide breakdown.
Milton NG
Biochem J. 1999
PubMed ID: 10567208
The amyloid beta-protein precursor of Alzheimer's disease is degraded extracellularly by a Kunitz protease inhibitor domain-sensitive trypsin-like serine protease in cultures of chick sympathetic neurons.
Caswell MD, Mok SS, Henry A, Cappai R, Klug G, Beyreuther K, Masters CL, Small DH
Eur J Biochem. 1999
PubMed ID: 10561592
Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.
Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tolnay M, Wiederhold KH, Abramowski D, Sturchler-Pierrat C, Sommer B, Staufenbiel M, Jucker M
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10570203
In vitro processing of amyloid precursor protein by cathepsin D.
Sadik G, Kaji H, Takeda K, Yamagata F, Kameoka Y, Hashimoto K, Miyanaga K, Shinoda T
Int J Biochem Cell Biol. 1999
PubMed ID: 10605825
A quantitative and immunohistochemical study on apolipoprotein E in brain tissue in Alzheimer's disease.
Hesse C, Bogdanovic N, Davidsson P, Blennow K
Dement Geriatr Cogn Disord. 1999
PubMed ID: 10559559
The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures.
White AR, Multhaup G, Maher F, Bellingham S, Camakaris J, Zheng H, Bush AI, Beyreuther K, Masters CL, Cappai R
J Neurosci. 1999
PubMed ID: 10531420
N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression.
Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM
J Biol Chem. 1999
PubMed ID: 10531386
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M
Science. 1999
PubMed ID: 10531052
Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.
White AR, Reyes R, Mercer JF, Camakaris J, Zheng H, Bush AI, Multhaup G, Beyreuther K, Masters CL, Cappai R
Brain Res. 1999
PubMed ID: 10526140
Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress.
Varadarajan S, Yatin S, Kanski J, Jahanshahi F, Butterfield DA
Brain Res Bull. 1999
PubMed ID: 10535332
Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein.
Ruiz FH, González M, Bodini M, Opazo C, Inestrosa NC
J Neurochem. 1999
PubMed ID: 10461923
Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
Homayouni R, Rice DS, Sheldon M, Curran T
J Neurosci. 1999
PubMed ID: 10460257
Identification and genetic mapping of differentially expressed genes in mice differing at the If1 interferon regulatory locus.
Kozak CA, Su Y, Raj NB, Pitha PM
Mamm Genome. 1999
PubMed ID: 10441734
Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum.
Campion D, Dumanchin C, Hannequin D, Dubois B, Belliard S, Puel M, Thomas-Anterion C, Michon A, Martin C, Charbonnier F, Raux G, Camuzat A, Penet C, Mesnage V, Martinez M, Clerget-Darpoux F, Brice A, Frebourg T
Am J Hum Genet. 1999
PubMed ID: 10441572
Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.
Nakagawa Y, Nakamura M, McIntosh TK, Rodriguez A, Berlin JA, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Schmidt ML, Lee VM, Trojanowski JQ
J Comp Neurol. 1999
PubMed ID: 10413774
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J
J Biol Chem. 1999
PubMed ID: 10438520
Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes.
McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K
Neurobiol Dis. 1999
PubMed ID: 10448051
Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Lamb BT, Bardel KA, Kulnane LS, Anderson JJ, Holtz G, Wagner SL, Sisodia SS, Hoeger EJ
Nat Neurosci. 1999
PubMed ID: 10412057
Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease.
Liu ST, Howlett G, Barrow CJ
Biochemistry. 1999
PubMed ID: 10413512
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse.
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P
Nature. 1999
PubMed ID: 10408445
Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42.
Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH
J Biol Chem. 1999
PubMed ID: 10383380
Production of amyloid beta protein precursor as a proteinase inhibitor by human astrocytic tumors.
Nakagawa T, Kabuto M, Kubota T, Kodera T, Sato K
Anticancer Res. 1999
PubMed ID: 10652580
The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction.
Huang X, Atwood CS, Hartshorn MA, Multhaup G, Goldstein LE, Scarpa RC, Cuajungco MP, Gray DN, Lim J, Moir RD, Tanzi RE, Bush AI
Biochemistry. 1999
PubMed ID: 10386999
Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.
Li QX, Maynard C, Cappai R, McLean CA, Cherny RA, Lynch T, Culvenor JG, Trevaskis J, Tanner JE, Bailey KA, Czech C, Bush AI, Beyreuther K, Masters CL
J Neurochem. 1999
PubMed ID: 10349858
Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.
Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T
J Neurosci. 1999
PubMed ID: 10341243
Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease.
Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jörnvall H
FEBS Lett. 1999
PubMed ID: 10371197
Apoptosis. Dead end for neurodegeneration?
Haass C
Nature. 1999
PubMed ID: 10353238
Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase.
Isohara T, Horiuchi A, Watanabe T, Ando K, Czernik AJ, Uno I, Greengard P, Nairn AC, Suzuki T
Biochem Biophys Res Commun. 1999
PubMed ID: 10329382
Binding of gelsolin, a secretory protein, to amyloid beta-protein.
Chauhan VP, Ray I, Chauhan A, Wisniewski HM
Biochem Biophys Res Commun. 1999
PubMed ID: 10329371
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation.
Gervais FG, Xu D, Robertson GS, Vaillancourt JP, Zhu Y, Huang J, LeBlanc A, Smith D, Rigby M, Shearman MS, Clarke EE, Zheng H, Van Der Ploeg LH, Ruffolo SC, Thornberry NA, Xanthoudakis S, Zamboni RJ, Roy S, Nicholson DW
Cell. 1999
PubMed ID: 10319819
Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein.
Magara F, Müller U, Li ZW, Lipp HP, Weissmann C, Stagljar M, Wolfer DP
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10200318
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R
Nature. 1999
PubMed ID: 10206645
Effect of HIV-1 gp41 peptides on secretion of beta-amyloid precursor protein in human astroglial cell line, T98G.
Chong YH, Lee MJ
J Mol Neurosci. 1999
PubMed ID: 10527458
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW
Nat Struct Biol. 1999
PubMed ID: 10201399
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein.
Dawson GR, Seabrook GR, Zheng H, Smith DW, Graham S, O'Dowd G, Bowery BJ, Boyce S, Trumbauer ME, Chen HY, Van der Ploeg LH, Sirinathsinghji DJ
Neuroscience. 1999
PubMed ID: 10188929
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.
Ancolio K, Dumanchin C, Barelli H, Warter JM, Brice A, Campion D, Frébourg T, Checler F
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10097173
Impairments in learning and memory accompanied by neurodegeneration in mice transgenic for the carboxyl-terminus of the amyloid precursor protein.
Berger-Sweeney J, McPhie DL, Arters JA, Greenan J, Oster-Granite ML, Neve RL
Brain Res Mol Brain Res. 1999
PubMed ID: 10095087
Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein.
Sabo SL, Lanier LM, Ikin AF, Khorkova O, Sahasrabudhe S, Greengard P, Buxbaum JD
J Biol Chem. 1999
PubMed ID: 10075692
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain.
Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F
J Biol Chem. 1999
PubMed ID: 10037741
Progress toward valid transgenic mouse models for Alzheimer's disease.
Guénette SY, Tanzi RE
Neurobiol Aging. 1999
PubMed ID: 10537029
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein.
Seabrook GR, Smith DW, Bowery BJ, Easter A, Reynolds T, Fitzjohn SM, Morton RA, Zheng H, Dawson GR, Sirinathsinghji DJ, Davies CH, Collingridge GL, Hill RG
Neuropharmacology. 1999
PubMed ID: 10219973
The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction.
Brouillet E, Trembleau A, Galanaud D, Volovitch M, Bouillot C, Valenza C, Prochiantz A, Allinquant B
J Neurosci. 1999
PubMed ID: 10024358
X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein.
Tanahashi H, Tabira T
Biochem Biophys Res Commun. 1999
PubMed ID: 10049767
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.
Tanahashi H, Tabira T
Neurosci Lett. 1999
PubMed ID: 10081969
A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein.
Watanabe T, Sukegawa J, Sukegawa I, Tomita S, Iijima K, Oguchi S, Suzuki T, Nairn AC, Greengard P
J Neurochem. 1999
PubMed ID: 9930726
Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.
Pradier L, Carpentier N, Delalonde L, Clavel N, Bock MD, Buée L, Mercken L, Tocqué B, Czech C
Neurobiol Dis. 1999
PubMed ID: 10078972
Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T
J Biol Chem. 1999
PubMed ID: 9890987
Analysis of mouse intron 7 DNA sequence of the APP gene: comparison with the human homologue.
Li L, Ohman T, Deeb SS, Fukuchi KI
DNA Seq. 1999
PubMed ID: 10727079
Transgenic animals in Alzheimer's disease research.
Sturchler-Pierrat C, Sommer B
Rev Neurosci. 1999
PubMed ID: 10356989
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice.
Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H, Jucker M
Neuroscience. 1999
PubMed ID: 10338291
Transgenic animals relevant to Alzheimer's disease.
Seabrook GR, Rosahl TW
Neuropharmacology. 1999
PubMed ID: 10193895
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.
Trommsdorff M, Borg JP, Margolis B, Herz J
J Biol Chem. 1998
PubMed ID: 9837937
PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein.
Zheng P, Eastman J, Vande Pol S, Pimplikar SW
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9843960
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ
J Biol Chem. 1998
PubMed ID: 9830016
Animal models in the development of symptomatic and preventive drug therapies for Alzheimer's disease.
Riekkinen P, Schmidt BH, van der Staay FJ
Ann Med. 1998
PubMed ID: 9920360
Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease.
Janciauskiene S, Wright HT
Bioessays. 1998
PubMed ID: 10048303
Transgenic mice expressing Alzheimer amyloid precursor proteins.
Hsiao K
Exp Gerontol. 1998
PubMed ID: 9951631
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
Buxbaum JD, Liu KN, Luo Y, Slack JL, Stocking KL, Peschon JJ, Johnson RS, Castner BJ, Cerretti DP, Black RA
J Biol Chem. 1998
PubMed ID: 9774383
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice.
Steinbach JP, Müller U, Leist M, Li ZW, Nicotera P, Aguzzi A
Cell Death Differ. 1998
PubMed ID: 10203685
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
Hu Q, Kukull WA, Bressler SL, Gray MD, Cam JA, Larson EB, Martin GM, Deeb SS
Hum Genet. 1998
PubMed ID: 9799084
Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.
Cras P, van Harskamp F, Hendriks L, Ceuterick C, van Duijn CM, Stefanko SZ, Hofman A, Kros JM, Van Broeckhoven C, Martin JJ
Acta Neuropathol. 1998
PubMed ID: 9754958
Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified beta-amyloid precursor protein gene.
Tremml P, Lipp HP, Müller U, Ricceri L, Wolfer DP
Behav Brain Res. 1998
PubMed ID: 9754878
Comparative gene mapping: a fine-scale survey of chromosome rearrangements between ruminants and humans.
Schibler L, Vaiman D, Oustry A, Giraud-Delville C, Cribiu EP
Genome Res. 1998
PubMed ID: 9750190
The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1.
Zambrano N, Minopoli G, de Candia P, Russo T
J Biol Chem. 1998
PubMed ID: 9685356
Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?
Coles M, Bicknell W, Watson AA, Fairlie DP, Craik DJ
Biochemistry. 1998
PubMed ID: 9693002
Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide.
Multhaup G, Ruppert T, Schlicksupp A, Hesse L, Bill E, Pipkorn R, Masters CL, Beyreuther K
Biochemistry. 1998
PubMed ID: 9585534
Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice.
Kindy MS, Rader DJ
Am J Pathol. 1998
PubMed ID: 9588907
Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress.
Smith MA, Hirai K, Hsiao K, Pappolla MA, Harris PL, Siedlak SL, Tabaton M, Perry G
J Neurochem. 1998
PubMed ID: 9572310
Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein.
Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T
J Biol Chem. 1998
PubMed ID: 9553108
Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles.
Takenaka M, Imai E, Kaneko T, Ito T, Moriyama T, Yamauchi A, Hori M, Kawamoto S, Okubo K
Kidney Int. 1998
PubMed ID: 9507200
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
Duilio A, Faraonio R, Minopoli G, Zambrano N, Russo T
Biochem J. 1998
PubMed ID: 9461550
Profiles of amyloid precursor and presenilin 2-like proteins are correlated during development of the mouse hypothalamus.
Apert C, Czech C, Faivre-Bauman A, Loudes C, Pradier L, Epelbaum J
J Neuroendocrinol. 1998
PubMed ID: 9535056
Alzheimer's disease: genetic studies and transgenic models.
Price DL, Tanzi RE, Borchelt DR, Sisodia SS
Annu Rev Genet. 1998
PubMed ID: 9928488
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes.
Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K
Nat Med. 1998
PubMed ID: 9427614
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
Perez RG, Zheng H, Van der Ploeg LH, Koo EH
J Neurosci. 1997
PubMed ID: 9390996
Amyloid precursor-like protein 1 accumulates in neuritic plaques in Alzheimer's disease.
Bayer TA, Paliga K, Weggen S, Wiestler OD, Beyreuther K, Multhaup G
Acta Neuropathol. 1997
PubMed ID: 9444352
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Rothacher S, Ledermann B, Bürki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9371838
Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
von Koch CS, Zheng H, Chen H, Trumbauer M, Thinakaran G, van der Ploeg LH, Price DL, Sisodia SS
Neurobiol Aging. 1997
PubMed ID: 9461064
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM
Nat Genet. 1997
PubMed ID: 9354781
A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J
Hum Mol Genet. 1997
PubMed ID: 9328472
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D
Nature. 1997
PubMed ID: 9338779
Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease.
Mok SS, Sberna G, Heffernan D, Cappai R, Galatis D, Clarris HJ, Sawyer WH, Beyreuther K, Masters CL, Small DH
FEBS Lett. 1997
PubMed ID: 9357988
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS
Neuron. 1997
PubMed ID: 9354339
Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.
Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK
Hum Mol Genet. 1997
PubMed ID: 9302276
Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA
Protein Sci. 1997
PubMed ID: 9300481
Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD
Hum Mol Genet. 1997
PubMed ID: 9285791
Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.
Aleshkov S, Abraham CR, Zannis VI
Biochemistry. 1997
PubMed ID: 9265639
Transgenic animals as models of neurodegenerative diseases in humans.
Theuring F, Thunecke M, Kosciessa U, Turner JD
Trends Biotechnol. 1997
PubMed ID: 9263480
Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.
Hammad SM, Ranganathan S, Loukinova E, Twal WO, Argraves WS
J Biol Chem. 1997
PubMed ID: 9228033
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9223340
High-resolution recombinational map of mouse chromosome 16.
Reeves RH, Rue EE, Citron MP, Cabin DE
Genomics. 1997
PubMed ID: 9244437
Alzheimer transgenic mouse models come of age.
Duff K
Trends Neurosci. 1997
PubMed ID: 9223216
Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.
Cáceres J, Brandan E
J Cell Biochem. 1997
PubMed ID: 9136074
A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus.
Hattori M, Tsukahara F, Furuhata Y, Tanahashi H, Hirose M, Saito M, Tsukuni S, Sakaki Y
Nucleic Acids Res. 1997
PubMed ID: 9108164
Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.
Walter MF, Mason PE, Mason RP
Biochem Biophys Res Commun. 1997
PubMed ID: 9168929
Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC.
Jensen PH, Hojrup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J, Jakes R
Biochem J. 1997
PubMed ID: 9163350
Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins.
Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T
J Biol Chem. 1997
PubMed ID: 9045663
Possible mechanism for resistance to Alzheimer's disease (AD) in mice suggests a new approach to generate a mouse model for sporadic AD and may explain familial resistance to AD in man.
Volloch V
Exp Neurol. 1997
PubMed ID: 9126173
The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.
Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T
Mol Med. 1997
PubMed ID: 9085254
Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations.
Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C
J Biol Chem. 1997
PubMed ID: 8999878
Expression of the APP gene family in brain cells, brain development and aging.
Sandbrink R, Mönning U, Masters CL, Beyreuther K
Gerontology. 1997
PubMed ID: 8996834
Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment.
Kohno T, Kobayashi K, Maeda T, Sato K, Takashima A
Biochemistry. 1996
PubMed ID: 8973180
Processing of beta-amyloid precursor protein by cathepsin D.
Higaki J, Catalano R, Guzzetta AW, Quon D, Navé JF, Tarnus C, D'Orchymont H, Cordell B
J Biol Chem. 1996
PubMed ID: 8943232
Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway.
Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD
J Biol Chem. 1996
PubMed ID: 8943215
A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Borchelt DR, Davis J, Fischer M, Lee MK, Slunt HH, Ratovitsky T, Regard J, Copeland NG, Jenkins NA, Sisodia SS, Price DL
Genet Anal. 1996
PubMed ID: 9117892
Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS
J Neurosci. 1996
PubMed ID: 8922407
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.
McLoughlin DM, Miller CC
FEBS Lett. 1996
PubMed ID: 8955346
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Borg JP, Ooi J, Levy E, Margolis B
Mol Cell Biol. 1996
PubMed ID: 8887653
Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.
Oster-Granite ML, McPhie DL, Greenan J, Neve RL
J Neurosci. 1996
PubMed ID: 8824314
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
Maruyama K, Tomita T, Shinozaki K, Kume H, Asada H, Saido TC, Ishiura S, Iwatsubo T, Obata K
Biochem Biophys Res Commun. 1996
PubMed ID: 8886002
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM
Hum Mol Genet. 1996
PubMed ID: 8894693
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Guénette SY, Chen J, Jondro PD, Tanzi RE
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8855266
Extracellular deposition of beta-amyloid upon p53-dependent neuronal cell death in transgenic mice.
LaFerla FM, Hall CK, Ngo L, Jay G
J Clin Invest. 1996
PubMed ID: 8833912
Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.
Reaume AG, Howland DS, Trusko SP, Savage MJ, Lang DM, Greenberg BD, Siman R, Scott RW
J Biol Chem. 1996
PubMed ID: 8798542
Degradation of Alzheimer's beta-amyloid protein by human cathepsin D.
McDermott JR, Gibson AM
Neuroreport. 1996
PubMed ID: 8930981
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Clusterin (Apo J) protects against in vitro amyloid-beta (1-40) neurotoxicity.
Boggs LN, Fuson KS, Baez M, Churgay L, McClure D, Becker G, May PC
J Neurochem. 1996
PubMed ID: 8752142
Alzheimer's amyloid precursor protein is expressed on the surface of hematopoietic cells upon activation.
Bullido MJ, Muñoz-Fernandez MA, Recuero M, Fresno M, Valdivieso F
Biochim Biophys Acta. 1996
PubMed ID: 8781550
Amyloid beta-protein and the genetics of Alzheimer's disease.
Selkoe DJ
J Biol Chem. 1996
PubMed ID: 8756120
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta.
Aplin AE, Gibb GM, Jacobsen JS, Gallo JM, Anderton BH
J Neurochem. 1996
PubMed ID: 8764598
Beta-amyloid (25-35) peptide and IFN-gamma synergistically induce the production of the chemotactic cytokine MCP-1/JE in monocytes and microglial cells.
Meda L, Bernasconi S, Bonaiuto C, Sozzani S, Zhou D, Otvos L, Mantovani A, Rossi F, Cassatella MA
J Immunol. 1996
PubMed ID: 8757628
Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
Li ZW, Stark G, Götz J, Rülicke T, Gschwind M, Huber G, Müller U, Weissmann C
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8650236
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.
Chow N, Korenberg JR, Chen XN, Neve RL
J Biol Chem. 1996
PubMed ID: 8626687
Genetic mapping of the gene for the mouse interferon-gamma receptor signaling subunit to the distal end of chromosome 16.
Mariano TM, Muthukumaran G, Donnelly RJ, Wang N, Adamson MC, Pestka S, Kozak CA
Mamm Genome. 1996
PubMed ID: 8661709
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F
EMBO J. 1996
PubMed ID: 8635459
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
Multhaup G, Schlicksupp A, Hesse L, Beher D, Ruppert T, Masters CL, Beyreuther K
Science. 1996
PubMed ID: 8596911
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
Beher D, Hesse L, Masters CL, Multhaup G
J Biol Chem. 1996
PubMed ID: 8576160
Neurotrophic and neuroprotective effects of hAPP in transgenic mice.
Mucke L, Abraham CR, Masliah E
Ann N Y Acad Sci. 1996
PubMed ID: 8624131
APP gene family. Alternative splicing generates functionally related isoforms.
Sandbrink R, Masters CL, Beyreuther K
Ann N Y Acad Sci. 1996
PubMed ID: 8624099
Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome.
Fan CM, Kuwana E, Bulfone A, Fletcher CF, Copeland NG, Jenkins NA, Crews S, Martinez S, Puelles L, Rubenstein JL, Tessier-Lavigne M
Mol Cell Neurosci. 1996
PubMed ID: 8812055
Genetic susceptibility to Alzheimer disease.
Pericak-Vance MA, Haines JL
Trends Genet. 1995
PubMed ID: 8533168
Serine proteinase inhibitors in human skeletal muscle: expression of beta-amyloid protein precursor and alpha 1-antichymotrypsin in vivo and during myogenesis in vitro.
Akaaboune M, Verdière-Sahuqué M, Lachkar S, Festoff BW, Hantaï D
J Cell Physiol. 1995
PubMed ID: 7593229
Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins.
Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D
Neuron. 1995
PubMed ID: 7576662
A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease.
Brooks WS, Martins RN, De Voecht J, Nicholson GA, Schofield PR, Kwok JB, Fisher C, Yeung LU, Van Broeckhoven C
Neurosci Lett. 1995
PubMed ID: 8577393
Axonal degeneration promotes abnormal accumulation of amyloid beta-protein in ascending gracile tract of gracile axonal dystrophy (GAD) mouse.
Ichihara N, Wu J, Chui DH, Yamazaki K, Wakabayashi T, Kikuchi T
Brain Res. 1995
PubMed ID: 8556328
Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease.
Sticht H, Bayer P, Willbold D, Dames S, Hilbich C, Beyreuther K, Frank RW, Rösch P
Eur J Biochem. 1995
PubMed ID: 7588758
Expression of the amyloid precursor protein of Alzheimer's disease on the surface of transfected HeLa cells.
Culvenor JG, Friedhuber A, Fuller SJ, Beyreuther K, Masters CL
Exp Cell Res. 1995
PubMed ID: 7556457
A mouse model for Down syndrome exhibits learning and behaviour deficits.
Reeves RH, Irving NG, Moran TH, Wohn A, Kitt C, Sisodia SS, Schmidt C, Bronson RT, Davisson MT
Nat Genet. 1995
PubMed ID: 7550346
Association of apolipoprotein E with murine amyloid A protein amyloid.
Kindy MS, King AR, Perry G, de Beer MC, de Beer FC
Lab Invest. 1995
PubMed ID: 7474917
Typing recombinant inbred mouse strains for microsatellite markers on chromosomes 10, 16, 18, 19, and X.
Taylor BA, Phillips SJ
Mamm Genome. 1995
PubMed ID: 8589516
Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.
Harrison SM, Dunwoodie SL, Arkell RM, Lehrach H, Beddington RS
Development. 1995
PubMed ID: 7671812
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK
Cell. 1995
PubMed ID: 7543026
Differential binding of vascular cell-derived proteoglycans (perlecan, biglycan, decorin, and versican) to the beta-amyloid protein of Alzheimer's disease.
Snow AD, Kinsella MG, Parks E, Sekiguchi RT, Miller JD, Kimata K, Wight TN
Arch Biochem Biophys. 1995
PubMed ID: 7793988
CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.
Mock BA, Connelly MA, McBride OW, Kozak CA, Marcu KB
Genomics. 1995
PubMed ID: 7558004
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH
Cell. 1995
PubMed ID: 7758106
The Alzheimer amyloid precursor proteoglycan (appican) is present in brain and is produced by astrocytes but not by neurons in primary neural cultures.
Shioi J, Pangalos MN, Ripellino JA, Vassilacopoulou D, Mytilineou C, Margolis RU, Robakis NK
J Biol Chem. 1995
PubMed ID: 7744833
The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene.
Pangalos MN, Efthimiopoulos S, Shioi J, Robakis NK
J Biol Chem. 1995
PubMed ID: 7737970
Protection against HIV-1 gp120-induced brain damage by neuronal expression of human amyloid precursor protein.
Mucke L, Abraham CR, Ruppe MD, Rockenstein EM, Toggas SM, Mallory M, Alford M, Masliah E
J Exp Med. 1995
PubMed ID: 7699335
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase,
Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H
Neuroscience. 1995
PubMed ID: 7542371
Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.
Brugg B, Dubreuil YL, Huber G, Wollman EE, Delhaye-Bouchaud N, Mariani J
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7708769
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F
Nature. 1995
PubMed ID: 7845465
The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.
Habets GG, van der Kammen RA, Jenkins NA, Gilbert DJ, Copeland NG, Hagemeijer A, Collard JG
Cytogenet Cell Genet. 1995
PubMed ID: 7736788
The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.
LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G
Nat Genet. 1995
PubMed ID: 7704018
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Müller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rülicke T, Brandner S, Aguzzi A, Weissmann C
Cell. 1994
PubMed ID: 8001115
Isolation of glyceraldehyde 3-phosphate dehydrogenase (Gapdh) cDNA from the distal half of mouse chromosome 16: further indication of a link between Alzheimer's disease and glycolysis.
Seipp S, Buselmaier W
Neurosci Lett. 1994
PubMed ID: 7891898
Multiple proteins interact at a unique cis-element in the 3'-untranslated region of amyloid precursor protein mRNA.
Zaidi SH, Denman R, Malter JS
J Biol Chem. 1994
PubMed ID: 7929050
Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension.
Jin LW, Ninomiya H, Roch JM, Schubert D, Masliah E, Otero DA, Saitoh T
J Neurosci. 1994
PubMed ID: 8083748
Processing of the pre-beta-amyloid protein by cathepsin D is enhanced by a familial Alzheimer's disease mutation.
Dreyer RN, Bausch KM, Fracasso P, Hammond LJ, Wunderlich D, Wirak DO, Davis G, Brini CM, Buckholz TM, König G
Eur J Biochem. 1994
PubMed ID: 7523115
Molecular and genetic characterization of GABP beta.
de la Brousse FC, Birkenmeier EH, King DS, Rowe LB, McKnight SL
Genes Dev. 1994
PubMed ID: 7958862
The beta A4 amyloid precursor protein binding to copper.
Hesse L, Beher D, Masters CL, Multhaup G
FEBS Lett. 1994
PubMed ID: 7913895
Solution structure of residues 1-28 of the amyloid beta-peptide.
Talafous J, Marcinowski KJ, Klopman G, Zagorski MG
Biochemistry. 1994
PubMed ID: 7516706
Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons.
Salbaum JM, Ruddle FH
J Exp Zool. 1994
PubMed ID: 8207383
Overexpression of a C-terminal portion of the beta-amyloid precursor protein in mouse brains by transplantation of transformed neuronal cells.
Fukuchi KI, Kunkel DD, Schwartzkroin PA, Kamino K, Ogburn CE, Furlong CE, Martin GM
Exp Neurol. 1994
PubMed ID: 8033965
Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity.
Hartmann H, Eckert A, Müller WE
Biochem Biophys Res Commun. 1994
PubMed ID: 8185566
PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials.
Bae SC, Ogawa E, Maruyama M, Oka H, Satake M, Shigesada K, Jenkins NA, Gilbert DJ, Copeland NG, Ito Y
Mol Cell Biol. 1994
PubMed ID: 8164679
Expression of beta-amyloid precursor protein in the developing human spinal cord.
Arai H, Higuchi S, Matsushita S, Yuzuriha T, Trojanowski JQ, Lee VM
Brain Res. 1994
PubMed ID: 8032873
A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth.
Small DH, Nurcombe V, Reed G, Clarris H, Moir R, Beyreuther K, Masters CL
J Neurosci. 1994
PubMed ID: 8158260
Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease.
Peacock ML, Murman DL, Sima AA, Warren JT, Roses AD, Fink JK
Ann Neurol. 1994
PubMed ID: 8154870
Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.
Suzuki T, Oishi M, Marshak DR, Czernik AJ, Nairn AC, Greengard P
EMBO J. 1994
PubMed ID: 8131745
The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.
Wisniewski T, Lalowski M, Levy E, Marques MR, Frangione B
Ann Neurol. 1994
PubMed ID: 8109908
Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene.
Farlow M, Murrell J, Ghetti B, Unverzagt F, Zeldenrust S, Benson M
Neurology. 1994
PubMed ID: 8290042
Insights into lipoprotein metabolism from studies in transgenic mice.
Breslow JL
Annu Rev Physiol. 1994
PubMed ID: 8010761
Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations.
Liepnieks JJ, Ghetti B, Farlow M, Roses AD, Benson MD
Biochem Biophys Res Commun. 1993
PubMed ID: 8267572
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.
Roher AE, Lowenson JD, Clarke S, Woods AS, Cotter RJ, Gowing E, Ball MJ
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8248178
Structural features of the 5' upstream regulatory region of the gene encoding rat amyloid precursor protein.
Chernak JM
Gene. 1993
PubMed ID: 8224912
Regional distribution of amyloid beta-protein precursor, growth-associated phosphoprotein-43 and microtubule-associated protein 2 messenger RNAs in the nigrostriatal system of normal and Weaver mutant mice and effects of ventral mesencephalic grafts.
Solà C, Mengod G, Low WC, Norton J, Ghetti B, Palacios JM, Triarhou LC
Eur J Neurosci. 1993
PubMed ID: 8287193
Characterization of beta-amyloid peptide from human cerebrospinal fluid.
Vigo-Pelfrey C, Lee D, Keim P, Lieberburg I, Schenk DB
J Neurochem. 1993
PubMed ID: 8229004
Regulation and expression of the Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome.
Beyreuther K, Pollwein P, Multhaup G, Mönning U, König G, Dyrks T, Schubert W, Masters CL
Ann N Y Acad Sci. 1993
PubMed ID: 8239320
Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]
Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD
Nat Genet. 1993
PubMed ID: 8220418
A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.
Bush AI, Multhaup G, Moir RD, Williamson TG, Small DH, Rumble B, Pollwein P, Beyreuther K, Masters CL
J Biol Chem. 1993
PubMed ID: 8344894
High-resolution mapping of D16led-1, Gart, Gas-4, Cbr, Pcp-4, and Erg on distal mouse chromosome 16.
Mjaatvedt AE, Citron MP, Reeves RH
Genomics. 1993
PubMed ID: 8406490
Interaction between the beta-amyloid peptide precursor and histones.
Potempska A, Ramakrishna N, Wisniewski HM, Miller DL
Arch Biochem Biophys. 1993
PubMed ID: 7688497
RFLP analysis for APP 717 mutations associated with Alzheimer's disease.
Zeldenrust SR, Murrell J, Farlow M, Ghetti B, Roses AD, Benson MD
J Med Genet. 1993
PubMed ID: 7686976
Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's beta-amyloid precursor protein.
Schulze H, Schuler A, Stüber D, Döbeli H, Langen H, Huber G
J Neurochem. 1993
PubMed ID: 8473906
C to T nucleotide substitution in codon 713 of amyloid precursor protein gene not found in 86 unrelated schizophrenics from multiplex families.
Coon H, Hoff M, Holik J, Delisi LE, Crowe T, Freedman R, Shields G, Boccio AM, Lerman M, Gershon ES
Am J Med Genet. 1993
PubMed ID: 8102836
A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor.
Denman RB, Rosenzcwaig R, Miller DL
Biochem Biophys Res Commun. 1993
PubMed ID: 8476439
Relocating a negative charge in the binding pocket of trypsin.
Perona JJ, Tsu CA, McGrath ME, Craik CS, Fletterick RJ
J Mol Biol. 1993
PubMed ID: 8478942
Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.
Gregor P, Reeves RH, Jabs EW, Yang X, Dackowski W, Rochelle JM, Brown RH, Haines JL, O'Hara BF, Uhl GR
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8464923
Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)
Nishimoto I, Okamoto T, Matsuura Y, Takahashi S, Okamoto T, Murayama Y, Ogata E
Nature. 1993
PubMed ID: 8446172
Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry.
Solà C, Mengod G, Ghetti B, Palacios JM, Triarhou LC
Brain Res Mol Brain Res. 1993
PubMed ID: 8510506
No mutation in codon 713 of the amyloid precursor gene in schizophrenic patients.
Carter D, Campion D, d'Amato T, Jay M, Brice A, Bellis M, Mallet J, Agid Y
Hum Mol Genet. 1993
PubMed ID: 8499923
The positions of 12 simple sequence repeat markers relative to reference loci on mouse chromosome 16.
Irving NG, Citron MP, Reeves RH
Mamm Genome. 1993
PubMed ID: 8358171
Segmental trisomy as a mouse model for Down syndrome.
Davisson MT, Schmidt C, Reeves RH, Irving NG, Akeson EC, Harris BS, Bronson RT
Prog Clin Biol Res. 1993
PubMed ID: 8115398
More missense in amyloid gene.
Carter DA, Desmarais E, Bellis M, Campion D, Clerget-Darpoux F, Brice A, Agid Y, Jaillard-Serradt A, Mallet J
Nat Genet. 1992
PubMed ID: 1303275
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.
Kamino K, Orr HT, Payami H, Wijsman EM, Alonso ME, Pulst SM, Anderson L, O'dahl S, Nemens E, White JA
Am J Hum Genet. 1992
PubMed ID: 1415269
Beta-amyloid precursor protein localization in the Golgi apparatus in neurons and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons.
Palacios G, Palacios JM, Mengod G, Frey P
Brain Res Mol Brain Res. 1992
PubMed ID: 1331676
Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids.
Seubert P, Vigo-Pelfrey C, Esch F, Lee M, Dovey H, Davis D, Sinha S, Schlossmacher M, Whaley J, Swindlehurst C
Nature. 1992
PubMed ID: 1406936
Schizophrenia scepticism.
Mant R, Asherson P, Gill M, McGuffin P, Owen M, Wert SE, Gregory RJ, Smith AE, Cohn JA, Wilson JM
Nat Genet. 1992
PubMed ID: 1303244
Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation.
de Sauvage F, Kruys V, Marinx O, Huez G, Octave JN
EMBO J. 1992
PubMed ID: 1353447
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, Winblad B, Lannfelt L
Nat Genet. 1992
PubMed ID: 1302033
Framing beta-amyloid.
Hardy J
Nat Genet. 1992
PubMed ID: 1363811
Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia.
Jones CT, Morris S, Yates CM, Moffoot A, Sharpe C, Brock DJ, St Clair D
Nat Genet. 1992
PubMed ID: 1307241
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.
Hendriks L, van Duijn CM, Cras P, Cruts M, Van Hul W, van Harskamp F, Warren A, McInnis MG, Antonarakis SE, Martin JJ
Nat Genet. 1992
PubMed ID: 1303239
Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.
König G, Mönning U, Czech C, Prior R, Banati R, Schreiter-Gasser U, Bauer J, Masters CL, Beyreuther K
J Biol Chem. 1992
PubMed ID: 1587857
Increased expression of beta-amyloid protein precursor and microtubule-associated protein tau during the differentiation of murine embryonal carcinoma cells.
Fukuchi K, Deeb SS, Kamino K, Ogburn CE, Snow AD, Sekiguchi RT, Wight TN, Piussan H, Martin GM
J Neurochem. 1992
PubMed ID: 1560239
Repression of the beta-amyloid gene in a Hox-3.1-producing cell line.
Violette SM, Shashikant CS, Salbaum JM, Belting HG, Wang JC, Ruddle FH
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1349171
Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse.
Izumi R, Yamada T, Yoshikai S, Sasaki H, Hattori M, Sakaki Y
Gene. 1992
PubMed ID: 1555768
The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported.
De Strooper B, Van Leuven F, Van den Berghe H
Biochim Biophys Acta. 1991
PubMed ID: 1756177
Mapping HSA 3 loci in cattle: additional support for the ancestral synteny of HSA 3 and 21.
Threadgill DS, Womack JE
Genomics. 1991
PubMed ID: 1783381
Mouse chromosome-specific markers generated by PCR and their mapping through interspecific backcrosses.
Irving NG, Brown SD
Genomics. 1991
PubMed ID: 1774069
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A, Rossor M, Roques P, Hardy J
Nature. 1991
PubMed ID: 1944558
Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein.
Heald SL, Tilton RF, Hammond LJ, Lee A, Bayney RM, Kamarck ME, Ramabhadran TV, Dreyer RN, Davis G, Unterbeck A
Biochemistry. 1991
PubMed ID: 1718421
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
Murrell J, Farlow M, Ghetti B, Benson MD
Science. 1991
PubMed ID: 1925564
DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type)
Bakker E, van Broeckhoven C, Haan J, Voorhoeve E, van Hul W, Levy E, Lieberburg I, Carman MD, van Ommen GJ, Frangione B
Am J Hum Genet. 1991
PubMed ID: 1679289
The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
Yoshioka K, Miki T, Katsuya T, Ogihara T, Sakaki Y
Biochem Biophys Res Commun. 1991
PubMed ID: 1908231
Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.
Tomasselli AG, Hui JO, Adams L, Chosay J, Lowery D, Greenberg B, Yem A, Deibel MR, Zürcher-Neely H, Heinrikson RL
J Biol Chem. 1991
PubMed ID: 1907279
Genomic organization of the human-amyloid beta-protein precursor gene.
Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y
Gene. 1991
PubMed ID: 1908403
Purification and tissue level of the beta-amyloid peptide precursor of rat brain.
Potempska A, Styles J, Mehta P, Kim KS, Miller DL
J Biol Chem. 1991
PubMed ID: 1673681
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
Naruse S, Igarashi S, Kobayashi H, Aoki K, Inuzuka T, Kaneko K, Shimizu T, Iihara K, Kojima T, Miyatake T
Lancet. 1991
PubMed ID: 1678058
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L
Nature. 1991
PubMed ID: 1671712
Synthesis and characterization of the Kunitz protease-inhibitor domain of the beta-amyloid precursor protein.
Schilling J, Wang Y, Lau K, Smith L, Cordell B
Gene. 1991
PubMed ID: 1707846
The multipoint genetic mapping of mouse chromosome 16.
Irving NG, Hardy JA, Brown SD
Genomics. 1991
PubMed ID: 1672298
X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor.
Hynes TR, Randal M, Kennedy LA, Eigenbrot C, Kossiakoff AA
Biochemistry. 1990
PubMed ID: 2125487
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Bodmer S, Podlisny MB, Selkoe DJ, Heid I, Fontana A
Biochem Biophys Res Commun. 1990
PubMed ID: 2119582
Sex, strain, and species differences affect recombination across an evolutionarily conserved segment of mouse chromosome 16.
Reeves RH, Crowley MR, O'Hara BF, Gearhart JD
Genomics. 1990
PubMed ID: 1981993
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GT, Luyendijk W, Frangione B
Science. 1990
PubMed ID: 2111584
Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.
Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD
Science. 1990
PubMed ID: 2110384
Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor.
Kido H, Fukutomi A, Schilling J, Wang Y, Cordell B, Katunuma N
Biochem Biophys Res Commun. 1990
PubMed ID: 1969731
Genomic organization of the human amyloid beta-protein precursor gene.
Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y
Gene. 1990
PubMed ID: 2110105
Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin.
Abraham CR, Shirahama T, Potter H
Neurobiol Aging. 1990
PubMed ID: 2190106
Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.
Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD
Nature. 1989
PubMed ID: 2507928
The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21.
Reeves RH, Crowley MR, Lorenzon N, Pavan WJ, Smeyne RJ, Goldowitz D
Genomics. 1989
PubMed ID: 2575584
Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor.
Johnstone EM, Chaney MO, Moore RE, Ward KE, Norris FH, Little SP
Biochem Biophys Res Commun. 1989
PubMed ID: 2675837
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.
Oltersdorf T, Fritz LC, Schenk DB, Lieberburg I, Johnson-Wood KL, Beattie EC, Ward PJ, Blacher RW, Dovey HF, Sinha S
Nature. 1989
PubMed ID: 2506449
A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein.
de Sauvage F, Octave JN
Science. 1989
PubMed ID: 2569763
Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus.
Fukuchi K, Martin GM, Deeb SS
Nucleic Acids Res. 1989
PubMed ID: 2569710
Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.
Patarca R, Freeman GJ, Singh RP, Wei FY, Durfee T, Blattner F, Regnier DC, Kozak CA, Mock BA, Morse HC
J Exp Med. 1989
PubMed ID: 2787378
The sequence of the two extra exons in rat preA4.
Kang J, Müller-Hill B
Nucleic Acids Res. 1989
PubMed ID: 2648331
Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene.
La Fauci G, Lahiri DK, Salton SR, Robakis NK
Biochem Biophys Res Commun. 1989
PubMed ID: 2538123
Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor.
Yamada T, Sasaki H, Dohura K, Goto I, Sakaki Y
Biochem Biophys Res Commun. 1989
PubMed ID: 2493250
The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons.
Lemaire HG, Salbaum JM, Multhaup G, Kang J, Bayney RM, Unterbeck A, Beyreuther K, Müller-Hill B
Nucleic Acids Res. 1989
PubMed ID: 2783775
The alpha 2 chain of type 1 collagen does not map to mouse chromosome 16 but maps close to the Met proto-oncogene on mouse chromosome 6.
Irving NG, Hardy JA, Bahary N, Friedman JM, Brown SD
Cytogenet Cell Genet. 1989
PubMed ID: 2776477
A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide.
Mita S, Sadlock J, Herbert J, Schon EA
Nucleic Acids Res. 1988
PubMed ID: 3140222
Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of human chromosome 21 to mouse chromosomes 16 and 17.
Cheng SV, Nadeau JH, Tanzi RE, Watkins PC, Jagadesh J, Taylor BA, Haines JL, Sacchi N, Gusella JF
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2901095
Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
Schubert D, Schroeder R, LaCorbiere M, Saitoh T, Cole G
Science. 1988
PubMed ID: 2968652
Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y
J Biol Chem. 1988
PubMed ID: 2834384
Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.
Shivers BD, Hilbich C, Multhaup G, Salbaum M, Beyreuther K, Seeburg PH
EMBO J. 1988
PubMed ID: 2900758
Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice.
Bendotti C, Forloni GL, Morgan RA, O'Hara BF, Oster-Granite ML, Reeves RH, Gearhart JD, Coyle JT
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2897124
Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.
Dyrks T, Weidemann A, Multhaup G, Salbaum JM, Lemaire HG, Kang J, Müller-Hill B, Masters CL, Beyreuther K
EMBO J. 1988
PubMed ID: 2900137
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity.
Kitaguchi N, Takahashi Y, Tokushima Y, Shiojiri S, Ito H
Nature. 1988
PubMed ID: 2893291
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL
Nature. 1988
PubMed ID: 2893290
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F
Nature. 1988
PubMed ID: 2893289
Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.
Zain SB, Salim M, Chou WG, Sajdel-Sulkowska EM, Majocha RE, Marotta CA
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2893379
Complementary DNA for the mouse homolog of the human amyloid beta protein precursor.
Yamada T, Sasaki H, Furuya H, Miyata T, Goto I, Sakaki Y
Biochem Biophys Res Commun. 1987
PubMed ID: 3322280
Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.
Pardridge WM, Vinters HV, Yang J, Eisenberg J, Choi TB, Tourtellotte WW, Huebner V, Shively JE
J Neurochem. 1987
PubMed ID: 3312495
Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimer's disease in man.
Reeves RH, Robakis NK, Oster-Granite ML, Wisniewski HM, Coyle JT, Gearhart JD
Brain Res. 1987
PubMed ID: 2960420
Purification of protease nexin II from human fibroblasts.
Van Nostrand WE, Cunningham DD
J Biol Chem. 1987
PubMed ID: 3597385
Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.
Robakis NK, Ramakrishna N, Wolfe G, Wisniewski HM
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3035574
The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16: further extension of the homology between human chromosome 21 and mouse chromosome 16.
Lovett M, Goldgaber D, Ashley P, Cox DR, Gajdusek DC, Epstein CJ
Biochem Biophys Res Commun. 1987
PubMed ID: 3555492
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.
Goldgaber D, Lerman MI, McBride OW, Saffiotti U, Gajdusek DC
Science. 1987
PubMed ID: 3810169
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.
Tanzi RE, Gusella JF, Watkins PC, Bruns GA, St George-Hyslop P, Van Keuren ML, Patterson D, Pagan S, Kurnit DM, Neve RL
Science. 1987
PubMed ID: 2949367
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Müller-Hill B
Nature. 1987
PubMed ID: 2881207
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3159021
Secondary amyloidosis and the serum amyloid precursor in leprosy: geographical variation and association with leukocytosis.
McAdam KP, Anders RF, Aiken G, Takitaki FF
Int J Lepr Other Mycobact Dis. 1977
PubMed ID: 561759
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	351	11820	54226
EnsEMBL Gene(s)	ENSG00000142192	ENSMUSG00000022892	ENSRNOG00000006997
Unigene	Hs.434980	Mm.277585	Rn.2104
Homologene	APP	App	App
OMIM	104760	N/A	N/A
GeneCards	APP	N/A	N/A
Beta Cell Genomics	DT.100680290 DT.100680291 DT.100894758 DT.456045 DT.92047441 DT.95298153 DT.97861505	DT.101226146 DT.101287752 DT.102548873 DT.103577624 DT.91330139 DT.94144862 DT.94144936 DT.94258333 DT.94312819 DT.94344131 DT.97368194 DT.97390493 DT.97390518 DT.97390521 DT.99867790	N/A
Reactome	P05067	N/A	N/A
Plasma Peptide Atlas	ENSP00000284981	N/A	N/A
WikiGenes	351	11820	54226

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
APP	AP1M2	IntAct	empirical	21163940
APP	PDIA6	IntAct	empirical	17934213
APP	BCAP31	HPRD	empirical	12529377
APP	CDK5	HPRD	empirical	8764598 10936190 15178331
APP	FLOT1	HPRD, IntAct	empirical	16480949
APP	STUB1	BioGRID	empirical	17317785
APP	APBB3	HPRD, IntAct, BioGRID	empirical	14527950 10081969 9461550 11517249
APP	SPON1	HPRD, IntAct	empirical	14983046 17934213
APP	APPBP2	HPRD, BioGRID	empirical	9843960
APP	KAT5	HPRD	empirical	12032152
APP	HYOU1	IntAct	empirical	17934213
APP	CDC37	IntAct	empirical	21163940
APP	CHRNA7	HPRD, IntAct	empirical	10681545
APP	TIRAP	IntAct	empirical	21988832
APP	CLU	HPRD	empirical	8752142 9228033
APP	SERPINA3	HPRD	empirical	10048303 2190106
APP	CNTN1	IntAct	empirical	17934213
APP	COL1A2	HPRD	empirical	7688497
APP	COL4A1	HPRD	empirical	9136074
APP	COL4A2	HPRD	empirical	9136074
APP	COL4A3	HPRD	empirical	9136074
APP	COL4A5	HPRD	empirical	9136074
APP	COL4A6	HPRD	empirical	9136074
APP	CPE	IntAct	empirical	17934213
APP	RNF32	IntAct	empirical	21163940
APP	CRYAB	HPRD, IntAct	empirical	17046756 16049941
APP	CST3	IntAct	empirical	17934213
APP	CTSD	HPRD, MINT	empirical	10605825 8943232 10931940 8930981 7523115 17112520
APP	CNTN4	IntAct	empirical	18272596
APP	DAB1	HPRD, IntAct, BioGRID	empirical	10460257 9837937 11517249
APP	DAB2	BioGRID	empirical	11247302
APP	DNM1	IntAct	empirical	16049941
APP	AGER	Reactome	predicted	10531386
APP	DNM2	IntAct	empirical	22036569
APP	A2M	IntAct	empirical	21163940
APP	TUBB	IntAct	empirical	16049941
APP	EPB41	HPRD	empirical	16368544
APP	F12	HPRD	empirical	11589915
APP	FBLN1	HPRD, BioGRID	empirical	11238726
APP	CLSTN1	IntAct	empirical	17934213 20925061
APP	MAST1	IntAct	empirical	21163940
APP	ERP44	IntAct	empirical	17934213
APP	NFASC	IntAct	empirical	17934213
APP	EPB41L3	IntAct	empirical	17934213
APP	FLOT2	IntAct	empirical	22036569
APP	GANAB	IntAct	empirical	17934213
APP	ARC	IntAct	empirical	22036569
APP	NCSTN	HPRD, IntAct, BioGRID	empirical	10993067 22036569
APP	FOS	IntAct	empirical	20195357
APP	MAPK8IP2	HPRD	empirical	12893827
APP	FPR2	Reactome	predicted	1374236
APP	BACE1	HPRD, IntAct	empirical	10531052
APP	STX12	IntAct	empirical	20925061
APP	ABL1	HPRD, MINT	empirical	11279131
APP	GABBR1	IntAct	empirical	17934213
APP	BACE2	HPRD	empirical	10605825 10931940 8764598 10936190 15178331
APP	GAPDH	HPRD	empirical	8473906
APP	DNAH1	IntAct	empirical	16049941
APP	LDLRAP1	HPRD	empirical	12805363
APP	GFAP	IntAct	empirical	16049941
APP	TNFRSF21	IntAct	empirical	19225519
APP	HTRA2	HPRD	empirical	15036614
APP	GNAO1	MIPS	empirical	10024358
APP	GPC1	HPRD	empirical	15084524
APP	LAMA1	HPRD	empirical	9136074
APP	GRB2	HPRD, MINT, BioGRID	empirical	12485888 17384289
APP	PDIA3	IntAct	empirical	15896298
APP	GSK3A	IntAct	empirical	16446437
APP	GSK3B	HPRD	empirical	8764598 10936190 15178331
APP	GSN	HPRD, BioGRID	empirical	10329371
APP	GTF2F2	IntAct	empirical	20195357
APP	SLC40A1	IntAct	empirical	20817278
APP	HSD17B10	HPRD, IntAct	empirical	15087549 10371197 9338779
APP	HADHB	HPRD	empirical	11430884
APP	HMOX2	HPRD	empirical	12057765
APP	APBA1	HPRD, MINT, IntAct, BioGRID	empirical	8887653 12196555
APP	APBA2	HPRD, MINT, IntAct, BioGRID	empirical	9890987 12196555 20925061 11517249 12972431
APP	APBB1	HPRD, MINT, IntAct, BioGRID	empirical	8887653 8955346 9799084 9837937 11085987 9045663 11517249 9461550 16049941 8855266 10081969 8894693
APP	APBB2	HPRD, IntAct, BioGRID	empirical	8855266 14527950 11517249
APP	HSPA4	IntAct, BioGRID	empirical	17934213 17317785
APP	HSPA5	IntAct	empirical	17934213
APP	HSPA8	IntAct	empirical	16049941
APP	HSP90AA1	IntAct, BioGRID	empirical	16049941 17317785
APP	HSPD1	BioGRID	empirical	17317785
APP	APLP1	IntAct	empirical	16193067 17934213
APP	HSPG2	HPRD	empirical	9136074
APP	APLP2	IntAct	empirical	16193067 17934213
APP	APOA1	IntAct	empirical	11297421
APP	IDE	HPRD	empirical	9830016
APP	IFIT3	IntAct	empirical	21163940
APP	APOE	HPRD, MIPS	empirical	10559559 9202294
APP	APP	IntAct	empirical	16193067 16286452
APP	JUN	IntAct	empirical	20195357
APP	KNG1	HPRD	empirical	12090937
APP	KLC1	HPRD, MIPS, BioGRID	empirical	11144355 17332754
APP	LRP1	HPRD	empirical	12212791 7543026
APP	MAPT	IntAct	empirical	16446437
APP	MAT1A	IntAct	empirical	17934213
APP	MBP	IntAct	empirical	16049941
APP	MDM2	IntAct	empirical	20195357
APP	MAP3K5	IntAct	empirical	16049941
APP	ACHE	HPRD, BioGRID	empirical	12427014
APP	MYH9	IntAct	empirical	16049941
APP	NBL1	MINT	empirical	12011466
APP	NCAM1	IntAct	empirical	17934213
APP	NEFL	IntAct	empirical	16049941
APP	NF1	HPRD, IntAct	empirical	16374483
APP	NGFR	IntAct	empirical	19225519
APP	NID1	HPRD	empirical	11376898
APP	NSF	IntAct	empirical	16049941
APP	ATP2B2	IntAct	empirical	17934213
APP	OAT	IntAct	empirical	17934213
APP	CNTN3	IntAct	empirical	18272596
APP	PARK2	BioGRID	empirical	19610108
APP	PCBD1	IntAct	empirical	20195357
APP	PGAM1	IntAct	empirical	16049941
APP	PIN1	HPRD, IntAct	empirical	16554819
APP	LRP1B	HPRD	empirical	15126508
APP	SHC3	HPRD, IntAct	empirical	11877420
APP	EXOC6	IntAct	empirical	21163940
APP	KIF1A	BioGRID	empirical	11144355
APP	PPIA	IntAct	empirical	16049941
APP	PPIB	IntAct	empirical	17934213
APP	PPID	HPRD	empirical	18806802
APP	PPP1R2	IntAct	empirical	17934213
APP	MAPK8	IntAct	empirical	11517249
APP	PRNP	IntAct	empirical	17934213 16286452
APP	PRSS2	HPRD	empirical	8478942
APP	PRSS3	HPRD	empirical	11827488
APP	KLK6	IntAct	empirical	12878203
APP	PSEN1	HPRD, IntAct, MIPS	empirical	10593990 9223340 21163940 10078972
APP	PSEN2	HPRD, IntAct, MIPS	empirical	10078972 9223340
APP	RCN2	IntAct	empirical	17934213
APP	ACTB	IntAct	empirical	16049941
APP	SLC5A7	IntAct	empirical	17709753
APP	BGN	HPRD, BioGRID	empirical	7793988
APP	NECAB3	HPRD	empirical	12780348
APP	SET	BioGRID	empirical	16162853
APP	BLMH	HPRD, IntAct, BioGRID	empirical	10973933 11350084
APP	SH3GL1	IntAct	empirical	22036569
APP	SH3GL3	IntAct	empirical	22036569
APP	SHC1	HPRD, MINT, IntAct, BioGRID	empirical	11877420 9045663 12485888 17384289
APP	SNCB	HPRD, BioGRID	empirical	9163350
APP	SNCA	HPRD	empirical	9163350
APP	SPTAN1	IntAct	empirical	16049941
APP	STXBP1	IntAct	empirical	16049941
APP	ADAM17	IntAct	empirical	9774383
APP	TAF9	IntAct	empirical	20195357
APP	TGFB1	HPRD, IntAct	empirical	12867422 2119582
APP	TGFB2	HPRD, IntAct	empirical	2119582
APP	THY1	IntAct	empirical	17934213
APP	TNF	IntAct	empirical	17623297
APP	TP53BP2	HPRD, IntAct	empirical	11278849
APP	TPD52L2	IntAct	empirical	21988832
APP	HSP90B1	IntAct	empirical	17934213
APP	UBC	BioGRID	empirical	17317785 20237263 21987572 21139048 21890473 21906983
APP	UCHL1	IntAct	empirical	16049941
APP	YWHAB	IntAct	empirical	16635246
APP	YWHAZ	IntAct	empirical	16049941
APP	CALR	HPRD, IntAct, BioGRID	empirical	11378243 17934213 15896298
APP	CALU	IntAct	empirical	17934213
APP	CANX	IntAct	empirical	17934213
APP	CASP3	HPRD	empirical	8943232 15178331
APP	CASP4	HPRD	empirical	15123740
APP	CASP6	HPRD	empirical	10438520
APP	TM2D1	HPRD	empirical	11278849
APP	SPARCL1	IntAct	empirical	17934213
APP	CASP8	HPRD	empirical	10911620
APP	PRAM1	IntAct	empirical	21163940
APP	SYVN1	BioGRID	empirical	20237263
APP	COL25A1	HPRD, BioGRID	empirical	11927537
APP	CAT	IntAct	empirical	10567208
APP	LINGO1	IntAct	empirical	17934213
APP	CAV1	HPRD, BioGRID	empirical	9553108
APP	CBFB	IntAct	empirical	20195357
APP	NUMB	HPRD, MINT	empirical	12011466
APP	RAB11A	IntAct	empirical	20925061
APP	NAE1	HPRD, BioGRID	empirical	8626687
APP	HGS	BioGRID	empirical	19019082
APP	NUMBL	HPRD	empirical	12011466
APP	ITM2B	HPRD	empirical	16027166
APP	ITM2A	IntAct	empirical	15983050
APP	HOMER3	HPRD, IntAct	empirical	18387811
APP	HOMER2	HPRD, IntAct	empirical	18387811
APP	MAPK8IP1	HPRD, MINT, IntAct	empirical	11517249 11724784 12893827
APP	APBA3	HPRD, MINT, MIPS, BioGRID	empirical	10049767 12196555
APP	CLSTN3	IntAct	empirical	17934213
APP	SRGAP3	IntAct	empirical	17934213