• About T1DBase
• Regions
  • Human T1D Regions
  • Mouse T1D Regions
    • Linkage Regions
    • Orthologous Regions
  • Rat T1D Regions
    • Linkage Regions
    • Orthologous Regions
    • QTL Regions
• Genome Browser
  • Human GBrowse
  • Mouse GBrowse
  • Rat GBrowse
• Tools
  • Gene Dossier
  • Beta Cell Gene Atlas
  • Batch Query
  • Sequence Search
  • HaemAtlas Search
  • Mouse Strain Search
• Data
  • Poster Pages
  • Downloads
  • Data Submission
• Help
  • FAQ
  • T1DBase Tutorial
• Contact Us

• Page Sections
  • Summary
  • Regions of Interest Overlapping this feature
  • Gene Overview
  • Beta Cell Gene Atlas
  • Tissue Expression
  • HaemAtlas Expression
  • Interactions
  • Cross-Reference to Pathways and GO Terms
  • Publications
  • Model Organism Phenotype Links
  • External Links
  • External resources (dkCOIN)

IGF2

Gene Description:   insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A) Synonyms:   FLJ44734, Igf-II, IGF2, C11orf43, IGF-II, M6pr, Mpr, AL033362, PP9974, Peg2, FLJ22066, Igf-2, Igf2, IGFII, RNIGF2 Orthologs:   Human IGF2 (protein-coding), Mouse Igf2 (protein-coding), Rat Igf2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, KEGG Human-Rat: HomoloGene, MGD, RGD, KEGG Mouse-Rat: HomoloGene, MGD, RGD, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 2 Rat: 3

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
11p15.5	Human	chr11:2068424..2308304	0.24	37	rs689 rs7111341

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	560

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 11p15.5 Orthologous Region	Mouse	chr7:149800921..150160408	0.36	6
Human 11p15.5 Orthologous Region	Rat	chr1:202870115..203251634	0.38	4
Iddm25	Rat	chr1:193831373..230411453	36.58	766

(Human) GRCh37 - chr11:2150342..2182439 (32.10 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr7:149836673..149852721 (165 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr1:202906624..202915231 (8.61 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Interactions Table for IGF2: The IGF2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs IGF2   GPC3   HPRD  empirical  8589713  IGF2   IDE   HPRD, BioGRID  empirical  1733942  IGF2   IGF1R   HPRD  empirical  9972281  IGF2   IGF2R   HPRD, MINT  empirical  7797478  9722981  18046459  IGF2   IGFALS   Reactome  predicted  12466191  7519608  12379487  10614670  7683646  15126567  11788658  9497324  11316783  10810289  8781553  7689487  9786878  17047378  9709957  12810533  10026136  15485880  10681634  15469690  7543116  11250653  2476804  1370451  IGF2   IGFBP1   HPRD, BioGRID, Reactome  empirical  10810289  12466191  7519608  12379487  7683646  8781553  7689487  7543116  17047378  9733769  IGF2   IGFBP2   HPRD, Reactome  empirical  1714916  8781553  2465304  11751371  12466191  7519608  12379487  7683646  2479552  10912521  7689487  7543116  17985932  17047378  IGF2   IGFBP3   HPRD, BioGRID, Reactome  empirical  10407151  11749962  11600567  9497324  9446566  12466191  7519608  12379487  9709957  7683646  11788658  12810533  15126567  10026136  11316783  10810289  15485880  8781553  10681634  15469690  7689487  7543116  17047378  11250653  2476804  1370451  IGF2   IGFBP4   HPRD, BioGRID, Reactome  empirical  9722589  12466191  7519608  12379487  7683646  12904166  8781553  7689487  15642270  17047378  IGF2   IGFBP5   HPRD, BioGRID, Reactome  empirical  9497324  12466191  7519608  12379487  10614670  7683646  15126567  11788658  11316783  10810289  8781553  7689487  9786878  17047378  IGF2   IGFBP6   HPRD, BioGRID, Reactome  empirical  7683646  12466191  12379487  15525596  8781553  7525263  7689487  17047378  15308688  10951195  IGF2   IGFBP7   HPRD, BioGRID  empirical  8939990  IGF2   INSR   HPRD  empirical  9722981  IGF2   NOV   HPRD, BioGRID  empirical  10084601  IGF2   PLG   HPRD  empirical  15642732  IGF2   PCSK4   HPRD  empirical  16040806  IGF2   SLC2A4   IntAct  empirical  16396496  IGF2   TF   BioGRID  empirical  11749962  IGF2   VTN   HPRD, BioGRID  empirical  10342887  IGF2   WISP2   HPRD  empirical  10358067

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: 2   Diabetes pathways REACT_15380 Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) REACT_15428

NCI-Nature Pathway Interaction Database: 1   Posttranslational regulation of adherens junction stability and dissassembly

Gene Ontology: 31   Skeletal system development GO:0001501 Ossification GO:0001503 Positive regulation of protein phosphorylation GO:0001934 Insulin receptor binding GO:0005158 Insulin-like growth factor receptor binding GO:0005159 Hormone activity GO:0005179 Protein binding GO:0005515 Extracellular region GO:0005576 Extracellular space GO:0005615 Carbohydrate metabolic process GO:0005975 Glucose metabolic process GO:0006006 Regulation of gene expression by genetic imprinting GO:0006349 Regulation of transcription, DNA-dependent GO:0006355 Multicellular organismal development GO:0007275 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Insulin receptor signaling pathway GO:0008286 Receptor activator activity GO:0030546 Positive regulation of activated T cell proliferation GO:0042104 Positive regulation of catalytic activity GO:0043085 Positive regulation of MAPKKK cascade GO:0043410 Protein serine/threonine kinase activator activity GO:0043539 Positive regulation of glycogen biosynthetic process GO:0045725 Positive regulation of mitosis GO:0045840 Positive regulation of insulin receptor signaling pathway GO:0046628 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Positive regulation of cell division GO:0051781 Positive regulation of protein kinase B signaling cascade GO:0051897 Positive regulation of protein serine/threonine kinase activity GO:0071902 Positive regulation of receptor activity GO:2000273 Positive regulation of glycogen (starch) synthase activity GO:2000467

	KEGG Network: None available
	Biocarta: None available
	Reactome: 2 Diabetes pathways REACT_15380 Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) REACT_15428
	NCI-Nature Pathway Interaction Database: 1 Posttranslational regulation of adherens junction stability and dissassembly
	Gene Ontology: 31 Skeletal system development GO:0001501 Ossification GO:0001503 Positive regulation of protein phosphorylation GO:0001934 Insulin receptor binding GO:0005158 Insulin-like growth factor receptor binding GO:0005159 Hormone activity GO:0005179 Protein binding GO:0005515 Extracellular region GO:0005576 Extracellular space GO:0005615 Carbohydrate metabolic process GO:0005975 Glucose metabolic process GO:0006006 Regulation of gene expression by genetic imprinting GO:0006349 Regulation of transcription, DNA-dependent GO:0006355 Multicellular organismal development GO:0007275 Growth factor activity GO:0008083 Positive regulation of cell proliferation GO:0008284 Insulin receptor signaling pathway GO:0008286 Receptor activator activity GO:0030546 Positive regulation of activated T cell proliferation GO:0042104 Positive regulation of catalytic activity GO:0043085 Positive regulation of MAPKKK cascade GO:0043410 Protein serine/threonine kinase activator activity GO:0043539 Positive regulation of glycogen biosynthetic process GO:0045725 Positive regulation of mitosis GO:0045840 Positive regulation of insulin receptor signaling pathway GO:0046628 Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 Positive regulation of cell division GO:0051781 Positive regulation of protein kinase B signaling cascade GO:0051897 Positive regulation of protein serine/threonine kinase activity GO:0071902 Positive regulation of receptor activity GO:2000273 Positive regulation of glycogen (starch) synthase activity GO:2000467

Type 1 Diabetes Publications: 29

• mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.
  Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J
  Genes Dev. 2011
  PubMed ID: 21576258
   
  
• Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in cited1 mutant mice.
  Novitskaya T, Baserga M, de Caestecker MP
  Endocrinology. 2011
  PubMed ID: 21486933
   
  
• Large solitary fibrous tumor with overexpression of insulin-like growth factor-2.
  Okabe R, Sonobe M, Bando T, Date H
  Interact Cardiovasc Thorac Surg. 2010
  PubMed ID: 20709701
   
  
• Mature IGF-II prevents the formation of "big" IGF-II/IGFBP-2 complex in the human circulation.
  Qiu Q, Yan X, Bell M, Di J, Tsang BK, Gruslin A
  Growth Horm IGF Res. 2010
  PubMed ID: 19962924
   
  
• A case of a giant phyllodes tumor of the breast with hypoglycemia caused by high-molecular-weight insulin-like growth factor II.
  Hino N, Nakagawa Y, Ikushima Y, Yoshida M, Tsuyuguchi M
  Breast Cancer. 2010
  PubMed ID: 19259766
   
  
• Undernutrition of the GK rat during gestation improves pancreatic IGF-2 and beta-cell mass in the fetuses.
  Fernández-Millán E, Gangnerau MN, De Miguel-Santos L, Calderari S, Serradas P, Escrivá F, Portha B, Alvarez C
  Growth Factors. 2009
  PubMed ID: 19919529
   
  
• High sensitivity of beta-cell replication to the inhibitory effects of interleukin-1beta: modulation by adenoviral overexpression of IGF2 in rat islets.
  Estil les E, Téllez N, Soler J, Montanya E
  J Endocrinol. 2009
  PubMed ID: 19592596
   
  
• Association of insulin-like growth factor 2 with the insulin-linked polymorphic region in cultured fetal thymus cells.
  Wang Y, Zhang H, Ligon LA, McGown LB
  Biochemistry. 2009
  PubMed ID: 19588890
   
  
• Maternal undernutrition increases pancreatic IGF-2 and partially suppresses the physiological wave of beta-cell apoptosis during the neonatal period.
  De Miguel-Santos L, Fernández-Millán E, Martín MA, Escrivá F, Alvarez C
  J Mol Endocrinol. 2009
  PubMed ID: 19648158
   
  
• Evaluation of IGF-2/ApaI polymorphism in pregnant women infected with human immunodeficiency virus type 1 taking antiretroviral drugs.
  Marcolin AC, Duarte G, Quintana SM, Araújo FM, El Beitune P, Gonçalves CV, Ramos ES
  Growth Horm IGF Res. 2009
  PubMed ID: 19560381
   
  
• Connective tissue growth factor is a downstream mediator for preptin-induced proliferation and differentiation in human osteoblasts.
  Liu YS, Lu Y, Liu W, Xie H, Luo XH, Wu XP, Yuan LQ, Liao EY
  Amino Acids. 2009
  PubMed ID: 19333718
   
  
• Insulin-like growth factors and insulin-like growth factor-binding proteins in relation to disease status and incidence of hypoglycaemia in patients with a gastrointestinal stromal tumour.
  Rikhof B, van Doorn J, Suurmeijer AJ, Rautenberg MW, Groenen PJ, Verdijk MA, Jager PL, de Jong S, Gietema JA, van der Graaf WT
  Ann Oncol. 2009
  PubMed ID: 19276395
   
  
• Hyperinsulinemic hypoglycemia with nesidioblastosis: histologic features and growth factor expression.
  Rumilla KM, Erickson LA, Service FJ, Vella A, Thompson GB, Grant CS, Lloyd RV
  Mod Pathol. 2009
  PubMed ID: 18931647
   
  
• Identification of transcripts with enriched expression in the developing and adult pancreas.
  Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones S, Marra MA, Helgason CD
  Genome Biol. 2008
  PubMed ID: 18554416
   
  
• A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
  Hakonarson H, Grant SF, Bradfield JP, Marchand L, Kim CE, Glessner JT, Grabs R, Casalunovo T, Taback SP, Frackelton EC, Lawson ML, Robinson LJ, Skraban R, Lu Y, Chiavacci RM, Stanley CA, Kirsch SE, Rappaport EF, Orange JS, Monos DS, Devoto M, Qu HQ, Polychronakos C
  Nature. 2007
  PubMed ID: 17632545
   
  
• Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes.
  Calderari S, Gangnerau MN, Thibault M, Meile MJ, Kassis N, Alvarez C, Portha B, Serradas P
  Diabetologia. 2007
  PubMed ID: 17476475
   
  
• Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.
  Cornish J, Callon KE, Bava U, Watson M, Xu X, Lin JM, Chan VA, Grey AB, Naot D, Buchanan CM, Cooper GJ, Reid IR
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 16912056
   
  
• Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits.
  Rodríguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Miller GJ, Humphries SE, Day IN
  Hum Mol Genet. 2004
  PubMed ID: 14749349
   
  
• Genetic factors and insulin secretion: gene variants in the IGF genes.
  't Hart LM, Fritsche A, Rietveld I, Dekker JM, Nijpels G, Machicao F, Stumvoll M, van Duijn CM, Häring HU, Heine RJ, Maassen JA, van Haeften TW
  Diabetes. 2004
  PubMed ID: 14749262
   
  
• Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.
  Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D
  J Biol Chem. 2002
  PubMed ID: 12101187
   
  
• Beta cell expression of IGF-I leads to recovery from type 1 diabetes.
  George M, Ayuso E, Casellas A, Costa C, Devedjian JC, Bosch F
  J Clin Invest. 2002
  PubMed ID: 11994404
   
  
• Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
  Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ
  Endocrinology. 2002
  PubMed ID: 11897712
   
  
• Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion.
  Buchanan CM, Phillips AR, Cooper GJ
  Biochem J. 2001
  PubMed ID: 11716772
   
  
• Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6.
  Bond JJ, Meka S, Baxter RC
  J Endocrinol. 2000
  PubMed ID: 10810289
   
  
• Overexpression of insulin-like growth factor-II in transgenic mice is associated with pancreatic islet cell hyperplasia.
  Petrik J, Pell JM, Arany E, McDonald TJ, Dean WL, Reik W, Hill DJ
  Endocrinology. 1999
  PubMed ID: 10218989
   
  
• Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18.
  Kovács P, Voigt B, Klöting I
  Biochem Biophys Res Commun. 1997
  PubMed ID: 9199194
   
  
• Deregulation of both imprinted and expressed alleles of the insulin-like growth factor 2 gene during beta-cell tumorigenesis.
  Christofori G, Naik P, Hanahan D
  Nat Genet. 1995
  PubMed ID: 7663515
   
  
• Detection of insulin and insulin-like growth factors I and II in saliva and potential synthesis in the salivary glands of mice. Effects of type 1 diabetes mellitus.
  Kerr M, Lee A, Wang PL, Purushotham KR, Chegini N, Yamamoto H, Humphreys-Beher MG
  Biochem Pharmacol. 1995
  PubMed ID: 7763295
   
  
• A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis.
  Christofori G, Naik P, Hanahan D
  Nature. 1994
  PubMed ID: 7910953
   
  

Publications: 762

• Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors.
  Lorenz A, Deutschmann M, Ahlfeld J, Prix C, Koch A, Smits R, Fodde R, Kretzschmar HA, Schüller U
  Mol Cell Biol. 2011
  PubMed ID: 21690300
   
  
• Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice.
  Sferruzzi-Perri AN, Vaughan OR, Coan PM, Suciu MC, Darbyshire R, Constancia M, Burton GJ, Fowden AL
  Endocrinology. 2011
  PubMed ID: 21673101
   
  
• Insulin growth factor-2 binding protein 3 (IGF2BP3) is a glioblastoma-specific marker that activates phosphatidylinositol 3-kinase/mitogen-activated protein kinase (PI3K/MAPK) pathways by modulating IGF-2.
  Suvasini R, Shruti B, Thota B, Shinde SV, Friedmann-Morvinski D, Nawaz Z, Prasanna KV, Thennarasu K, Hegde AS, Arivazhagan A, Chandramouli BA, Santosh V, Somasundaram K
  J Biol Chem. 2011
  PubMed ID: 21613208
   
  
• Novel cis-regulatory function in ICR-mediated imprinted repression of H19.
  Ideraabdullah FY, Abramowitz LK, Thorvaldsen JL, Krapp C, Wen SC, Engel N, Bartolomei MS
  Dev Biol. 2011
  PubMed ID: 21600199
   
  
• The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
  Billington CJ, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A
  Dev Biol. 2011
  PubMed ID: 21549111
   
  
• DNA methylation at H19/IGF2 ICR1 in the placenta of pregnancies conceived by in vitro fertilization and intracytoplasmic sperm injection.
  Wong EC, Hatakeyama C, Robinson WP, Ma S
  Fertil Steril. 2011
  PubMed ID: 21704210
   
  
• Insulin-like growth factor 2 enhances insulinogenic differentiation of human eyelid adipose stem cells via the insulin receptor.
  Kang HM, Park S, Kim H
  Cell Prolif. 2011
  PubMed ID: 21535266
   
  
• Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients.
  El Tayebi HM, Salah W, El Sayed IH, Salam EM, Zekri AR, Zayed N, Salem ES, Esmat G, Abdelaziz AI
  Biomarkers. 2011
  PubMed ID: 21506705
   
  
• Extra-embryonic-specific imprinted expression is restricted to defined lineages in the post-implantation embryo.
  Hudson QJ, Seidl CI, Kulinski TM, Huang R, Warczok KE, Bittner R, Bartolomei MS, Barlow DP
  Dev Biol. 2011
  PubMed ID: 21354127
   
  
• Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II.
  Zhang H, Niu B, Hu JF, Ge S, Wang H, Li T, Ling J, Steelman BN, Qian G, Hoffman AR
  J Cell Biol. 2011
  PubMed ID: 21536749
   
  
• IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development.
  Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov HM
  Development. 2011
  PubMed ID: 21429986
   
  
• Deletions and rearrangements of the H19/IGF2 enhancer region in patients with Silver-Russell syndrome and growth retardation.
  Grønskov K, Poole RL, Hahnemann JM, Thomson J, Tümer Z, Brøndum-Nielsen K, Murphy R, Ravn K, Melchior L, Dedic A, Dolmer B, Temple IK, Boonen SE, Mackay DJ
  J Med Genet. 2011
  PubMed ID: 21278389
   
  
• Loss of imprinting and abnormal expression of the insulin-like growth factor 2 gene in gastric cancer.
  Zuo QS, Yan R, Feng DX, Zhao R, Chen C, Jiang YM, Cruz-Correa M, Casson AG, Kang XD, Han F, Chen T
  Mol Carcinog. 2011
  PubMed ID: 21268128
   
  
• Association between endometriosis and polymorphisms in insulin-like growth factors (IGFs) and IGF-I receptor genes in Korean women.
  Kim H, Park JH, Ku SY, Kim SH, Choi YM, Kim JG
  Eur J Obstet Gynecol Reprod Biol. 2011
  PubMed ID: 21251749
   
  
• Maternal serum and cord blood preptin levels in gestational diabetes mellitus.
  Aslan M, Celik O, Karsavuran N, Celik N, Dogan DG, Botan E, Kafkasli A
  J Perinatol. 2011
  PubMed ID: 21164426
   
  
• Overexpression of the IGF2-mRNA binding protein p62 in transgenic mice induces a steatotic phenotype.
  Tybl E, Shi FD, Kessler SM, Tierling S, Walter J, Bohle RM, Wieland S, Zhang J, Tan EM, Kiemer AK
  J Hepatol. 2011
  PubMed ID: 21145819
   
  
• IGF-II and MMP9 as surgical repair indicators of ventricular septal defects.
  Tsai CY, Lai CH, Chang MH, Jong GP, Cheng YC, Tsai FJ, Tsai CH, Kuo WH, Hsieh DJ, Huang CY
  Clin Chim Acta. 2011
  PubMed ID: 21238444
   
  
• A systems biology approach: new insights into fetal growth restriction using Bayesian Networks.
  Foltran F, Berchialla P, Bernasconi S, Grossi E, Gregori D, Street ME
  J Biol Regul Homeost Agents. 2011
  PubMed ID: 21880216
   
  
• Insulin-like growth factor-2 (IGF-2) activates estrogen receptor-α and -β via the IGF-1 and the insulin receptors in breast cancer cells.
  Richardson AE, Hamilton N, Davis W, Brito C, De León D
  Growth Factors. 2011
  PubMed ID: 21410323
   
  
• Disruption of genomic neighbourhood at the imprinted IGF2-H19 locus in Beckwith-Wiedemann syndrome and Silver-Russell syndrome.
  Nativio R, Sparago A, Ito Y, Weksberg R, Riccio A, Murrell A
  Hum Mol Genet. 2011
  PubMed ID: 21282187
   
  
• Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.
  Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J
  Hum Mol Genet. 2011
  PubMed ID: 21233130
   
  
• Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
  Oh-McGinnis R, Bogutz AB, Lefebvre L
  Dev Biol. 2011
  PubMed ID: 21238448
   
  
• The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.
  Lehtinen MK, Zappaterra MW, Chen X, Yang YJ, Hill AD, Lun M, Maynard T, Gonzalez D, Kim S, Ye P, D'Ercole AJ, Wong ET, LaMantia AS, Walsh CA
  Neuron. 2011
  PubMed ID: 21382550
   
  
• Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis.
  Blank MC, Grinberg I, Aryee E, Laliberte C, Chizhikov VV, Henkelman RM, Millen KJ
  Development. 2011
  PubMed ID: 21307096
   
  
• Coexpression of an intronic microRNA and its host gene reveals a potential role for miR-483-5p as an IGF2 partner.
  Ma N, Wang X, Qiao Y, Li F, Hui Y, Zou C, Jin J, Lv G, Peng Y, Wang L, Huang H, Zhou L, Zheng X, Gao X
  Mol Cell Endocrinol. 2011
  PubMed ID: 21146586
   
  
• Regulation of IGF2 transcript and protein expression by altered methylation in breast cancer.
  Shetty PJ, Movva S, Pasupuleti N, Vedicherlla B, Vattam KK, Venkatasubramanian S, Ahuja YR, Hasan Q
  J Cancer Res Clin Oncol. 2011
  PubMed ID: 20422427
   
  
• A critical role for IGF-II in memory consolidation and enhancement.
  Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM
  Nature. 2011
  PubMed ID: 21270887
   
  
• IGF-II is regulated by microRNA-125b in skeletal myogenesis.
  Ge Y, Sun Y, Chen J
  J Cell Biol. 2011
  PubMed ID: 21200031
   
  
• Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation.
  Hu Q, Gao F, Tian W, Ruteshouser EC, Wang Y, Lazar A, Stewart J, Strong LC, Behringer RR, Huff V
  J Clin Invest. 2011
  PubMed ID: 21123950
   
  
• Rhabdomyosarcoma: molecular analysis of Igf2, MyoD1 and Myogenin expression.
  Krskova L, Augustinakova A, Drahokoupilova E, Sumerauer D, Mudry P, Kodet R
  Neoplasma. 2011
  PubMed ID: 21744995
   
  
• Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma.
  Ahmad W, Shabbiri K, Ijaz B, Asad S, Nazar N, Nazar S, Fouzia K, Kausar H, Gull S, Sarwar MT, Shahid I, Hassan S
  Virol J. 2011
  PubMed ID: 21548981
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts.
  Hardouin SN, Guo R, Romeo PH, Nagy A, Aubin JE
  Development. 2011
  PubMed ID: 21148188
   
  
• Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2.
  Brade T, Kumar S, Cunningham TJ, Chatzi C, Zhao X, Cavallero S, Li P, Sucov HM, Ruiz-Lozano P, Duester G
  Development. 2011
  PubMed ID: 21138976
   
  
• IGF-II promoter specific methylation and expression in epithelial ovarian cancer and their associations with disease characteristics.
  Qian B, Katsaros D, Lu L, Canuto EM, Benedetto C, Beeghly-Fadiel A, Yu H
  Oncol Rep. 2011
  PubMed ID: 21109978
   
  
• TGF-β inhibits muscle differentiation by blocking autocrine signaling pathways initiated by IGF-II.
  Gardner S, Alzhanov D, Knollman P, Kuninger D, Rotwein P
  Mol Endocrinol. 2011
  PubMed ID: 21106882
   
  
• Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.
  Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ
  J Biol Chem. 2010
  PubMed ID: 21047779
   
  
• Subtypes of medulloblastoma have distinct developmental origins.
  Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, Ogg R, Pei Y, Yang ZJ, Brun S, Lee Y, Zindy F, Lindsey JC, Taketo MM, Boop FA, Sanford RA, Gajjar A, Clifford SC, Roussel MF, McKinnon PJ, Gutmann DH, Ellison DW, Wechsler-Reya R, Gilbertson RJ
  Nature. 2010
  PubMed ID: 21150899
   
  
• Long range interactions regulate Igf2 gene transcription during skeletal muscle differentiation.
  Alzhanov DT, McInerney SF, Rotwein P
  J Biol Chem. 2010
  PubMed ID: 20937833
   
  
• Cervical scrapes levels of insulin-like growth factor-II and insulin-like growth factor binding protein 3 in women with squamous intraepithelial lesions and cervical cancer.
  Serrano ML, Sánchez-Gómez M, Bravo MM
  Horm Metab Res. 2010
  PubMed ID: 20945273
   
  
• Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation.
  Kim ST, Cheng Y, Hsu FC, Jin T, Kader AK, Zheng SL, Isaacs WB, Xu J, Sun J
  Prostate. 2010
  PubMed ID: 20564319
   
  
• Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk.
  McGrath M, Lee IM, Buring J, De Vivo I
  Gynecol Oncol. 2010
  PubMed ID: 21078522
   
  
• A large-scale candidate gene association study of age at menarche and age at natural menopause.
  He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
  Hum Genet. 2010
  PubMed ID: 20734064
   
  
• A genomic imprinting defect in mice traced to a single gene.
  Rentsendorj A, Mohan S, Szabó P, Mann JR
  Genetics. 2010
  PubMed ID: 20713691
   
  
• Association of birth weight with polymorphisms in the IGF2, H19, and IGF2R genes.
  Adkins RM, Somes G, Morrison JC, Hill JB, Watson EM, Magann EF, Krushkal J
  Pediatr Res. 2010
  PubMed ID: 20639793
   
  
• Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation.
  Chen L, Jiang W, Huang J, He BC, Zuo GW, Zhang W, Luo Q, Shi Q, Zhang BQ, Wagner ER, Luo J, Tang M, Wietholt C, Luo X, Bi Y, Su Y, Liu B, Kim SH, He CJ, Hu Y, Shen J, Rastegar F, Huang E, Gao Y, Gao JL, Zhou JZ, Reid RR, Luu HH, Haydon RC, He TC, Deng ZL
  J Bone Miner Res. 2010
  PubMed ID: 20499340
   
  
• Glatiramer acetate-reactive T lymphocytes regulate oligodendrocyte progenitor cell number in vitro: role of IGF-2.
  Zhang Y, Jalili F, Ouamara N, Zameer A, Cosentino G, Mayne M, Hayardeny L, Antel JP, Bar-Or A, John GR
  J Neuroimmunol. 2010
  PubMed ID: 20637510
   
  
• A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
  Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20673868
   
  
• Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation.
  Gong L, Pan YX, Chen H
  Epigenetics. 2010
  PubMed ID: 20671425
   
  
• Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
  Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS
  Hum Mol Genet. 2010
  PubMed ID: 20634197
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Upregulation of IGF2 is associated with an acquired resistance for cis-diamminedichloroplatinum in human head and neck squamous cell carcinoma.
  Ogawa T, Ogawa K, Shiga K, Furukawa T, Nagase H, Hashimoto S, Kobayashi T, Horii A
  Eur Arch Otorhinolaryngol. 2010
  PubMed ID: 20443017
   
  
• Down-regulation of achaete-scute complex homolog 1 (ASCL1) in neuroblastoma cells induces up-regulation of insulin-like growth factor 2 (IGF2).
  Li J, Neumann I, Volkmer I, Staege MS
  Mol Biol Rep. 2010
  PubMed ID: 20842449
   
  
• Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.
  Stange DE, Engel F, Longerich T, Koo BK, Koch M, Delhomme N, Aigner M, Toedt G, Schirmacher P, Lichter P, Weitz J, Radlwimmer B
  Gut. 2010
  PubMed ID: 20479215
   
  
• Brain weight in males is correlated with DNA methylation at IGF2.
  Pidsley R, Dempster EL, Mill J
  Mol Psychiatry. 2010
  PubMed ID: 20010889
   
  
• Genomic imprinting status of IGF-II and H19 in placentas of fetal growth restriction patients.
  Ying W, Jingli F, Wei SW, Li WL
  J Genet. 2010
  PubMed ID: 20861572
   
  
• Targeted tumor gene therapy based on loss of IGF2 imprinting.
  Pan Y, He B, Li T, Zhu C, Zhang L, Wang B, Xu Y, Qu L, Hoffman AR, Wang S, Hu J
  Cancer Biol Ther. 2010
  PubMed ID: 20592487
   
  
• Investigation of IGF2/ApaI and H19/RsaI polymorphisms in patients with cutaneous melanoma.
  Soares MR, Huber J, Rios AF, Ramos ES
  Growth Horm IGF Res. 2010
  PubMed ID: 20483645
   
  
• Brief, high intensity exercise alters serum ghrelin and growth hormone concentrations but not IGF-I, IGF-II or IGF-I bioactivity.
  Stokes KA, Sykes D, Gilbert KL, Chen JW, Frystyk J
  Growth Horm IGF Res. 2010
  PubMed ID: 20472480
   
  
• Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.
  Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL, Li D
  Gastroenterology. 2010
  PubMed ID: 20416304
   
  
• Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer.
  Cheng YW, Idrees K, Shattock R, Khan SA, Zeng Z, Brennan CW, Paty P, Barany F
  Int J Cancer. 2010
  PubMed ID: 19957330
   
  
• Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.
  Cooley SM, Donnelly JC, Geary MP, Rodeck CH, Hindmarsh PC
  J Matern Fetal Neonatal Med. 2010
  PubMed ID: 20540659
   
  
• Gene expression pattern of IGF2, PHLDA2, PEG10 and CDKN1C imprinted genes in spontaneous miscarriages or fetal deaths.
  Dória S, Sousa M, Fernandes S, Ramalho C, Brandão O, Matias A, Barros A, Carvalho F
  Epigenetics. 2010
  PubMed ID: 20484977
   
  
• Association study of 182 candidate genes in anorexia nervosa.
  Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
  Am J Med Genet B Neuropsychiatr Genet. 2010
  PubMed ID: 20468064
   
  
• A Large-scale genetic association study of esophageal adenocarcinoma risk.
  Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
  Carcinogenesis. 2010
  PubMed ID: 20453000
   
  
• A population-based study of IGF axis polymorphisms and the esophageal inflammation, metaplasia, adenocarcinoma sequence.
  McElholm AR, McKnight AJ, Patterson CC, Johnston BT, Hardie LJ, Murray LJ, Finbar Group
  Gastroenterology. 2010
  PubMed ID: 20403354
   
  
• Insulin-like growth factors II exon 9 and E-cadherin-Pml I but not myeloperoxidase promoter-463, urokinase-ApaL I nor xeroderma pigmentosum polymorphisms are associated with higher susceptibility to leiomyoma.
  Hsieh YY, Chang CC, Wang YK, Hsu KH, Chen CP, Hsu CM, Tsai FJ
  Anticancer Res. 2010
  PubMed ID: 20651370
   
  
• A genomic atlas of mouse hypothalamic development.
  Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S
  Nat Neurosci. 2010
  PubMed ID: 20436479
   
  
• Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: findings from a nested case-control study within the Japan Collaborative Cohort Study.
  Pham TM, Fujino Y, Nakachi K, Suzuki K, Ito Y, Watanabe Y, Inaba Y, Tajima K, Tamakoshi A, Yoshimura T, JACC Study Group
  Cancer Epidemiol. 2010
  PubMed ID: 20427254
   
  
• Epigenetic modulation of the IGF2/H19 imprinted domain in human embryonic and extra-embryonic compartments and its possible role in fetal growth restriction.
  Tabano S, Colapietro P, Cetin I, Grati FR, Zanutto S, Mandò C, Antonazzo P, Pileri P, Rossella F, Larizza L, Sirchia SM, Miozzo M
  Epigenetics. 2010
  PubMed ID: 20418667
   
  
• Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
  Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20452482
   
  
• Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
  Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
  Cancer Prev Res (Phila Pa). 2010
  PubMed ID: 20403997
   
  
• IGF2 is highly expressed in pediatric undifferentiated sarcomas and reveals two distinct cytoplasmic trafficking patterns.
  Somers GR, Ho M, Pienkowska M, Shlien A, Malkin D, Ackerley C, Zielenska M
  Pediatr Dev Pathol. 2010
  PubMed ID: 19586133
   
  
• Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.
  Chou S, Lodish HF
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20385801
   
  
• Oncogenic role of miR-483-3p at the IGF2/483 locus.
  Veronese A, Lupini L, Consiglio J, Visone R, Ferracin M, Fornari F, Zanesi N, Alder H, D'Elia G, Gramantieri L, Bolondi L, Lanza G, Querzoli P, Angioni A, Croce CM, Negrini M
  Cancer Res. 2010
  PubMed ID: 20388800
   
  
• IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.
  Tovar V, Alsinet C, Villanueva A, Hoshida Y, Chiang DY, Solé M, Thung S, Moyano S, Toffanin S, Mínguez B, Cabellos L, Peix J, Schwartz M, Mazzaferro V, Bruix J, Llovet JM
  J Hepatol. 2010
  PubMed ID: 20206398
   
  
• Plasma insulin-like growth factor-binding protein-2 levels as diagnostic and prognostic biomarker of colorectal cancer.
  Liou JM, Shun CT, Liang JT, Chiu HM, Chen MJ, Chen CC, Wang HP, Wu MS, Lin JT
  J Clin Endocrinol Metab. 2010
  PubMed ID: 20157191
   
  
• A domesticated transposon mediates the effects of a single-nucleotide polymorphism responsible for enhanced muscle growth.
  Butter F, Kappei D, Buchholz F, Vermeulen M, Mann M
  EMBO Rep. 2010
  PubMed ID: 20134481
   
  
• Differential insulin-like growth factor II (IGF-II) expression: A potential role for breast cancer survival disparity.
  Kalla Singh S, Tan QW, Brito C, De León M, Garberoglio C, De León D
  Growth Horm IGF Res. 2010
  PubMed ID: 20089431
   
  
• Expression of the imprinted IGF2 and H19 genes in the endometrium of cases with unexplained infertility.
  Korucuoglu U, Biri AA, Konac E, Alp E, Onen IH, Ilhan MN, Turkyilmaz E, Erdem A, Erdem M, Menevse S
  Eur J Obstet Gynecol Reprod Biol. 2010
  PubMed ID: 20042264
   
  
• Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders.
  Demars J, Shmela ME, Rossignol S, Okabe J, Netchine I, Azzi S, Cabrol S, Le Caignec C, David A, Le Bouc Y, El-Osta A, Gicquel C
  Hum Mol Genet. 2010
  PubMed ID: 20007505
   
  
• Dairy intake associates with the IGF rs680 polymorphism to height variation in periadolescent children.
  Dedoussis GV, Louizou E, Papoutsakis C, Skenderi KP, Yannakoulia M
  Eur J Clin Nutr. 2010
  PubMed ID: 19953105
   
  
• Racial differences in the association between body mass index and serum IGF1, IGF2, and IGFBP3.
  Fowke JH, Matthews CE, Yu H, Cai Q, Cohen S, Buchowski MS, Zheng W, Blot WJ
  Endocr Relat Cancer. 2010
  PubMed ID: 19786462
   
  
• Placental-specific Igf2 knockout mice exhibit hypocalcemia and adaptive changes in placental calcium transport.
  Dilworth MR, Kusinski LC, Cowley E, Ward BS, Husain SM, Constância M, Sibley CP, Glazier JD
  Proc Natl Acad Sci U S A. 2010
  PubMed ID: 20133672
   
  
• Upregulation of imprinted genes in mice: an insight into the intensity of gene expression and the evolution of genomic imprinting.
  Zaitoun I, Downs KM, Rosa GJ, Khatib H
  Epigenetics. 2010
  PubMed ID: 20168089
   
  
• ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain.
  Kernohan KD, Jiang Y, Tremblay DC, Bonvissuto AC, Eubanks JH, Mann MR, Bérubé NG
  Dev Cell. 2010
  PubMed ID: 20159591
   
  
• Ligand-specific antibodies to insulin-like growth factors suppress intestinal polyp formation in Apc+/- mice.
  Matsunaka T, Miyamoto S, Shitara K, Ochiai A, Chiba T
  Mol Cancer Ther. 2010
  PubMed ID: 20103605
   
  
• Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis.
  Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF
  Endocrinology. 2010
  PubMed ID: 20032056
   
  
• Involvement of insulin-like growth factor 2 in angiogenic factor transcription in Bi-maternal mouse conceptuses.
  Kawahara M, Wu Q, Kono T
  J Reprod Dev. 2010
  PubMed ID: 19881219
   
  
• Relationship of Insulin-Like Growth Factors System Gene Polymorphisms with the Susceptibility and Pathological Development of Hepatocellular Carcinoma.
  Weng CJ, Hsieh YH, Tsai CM, Chu YH, Ueng KC, Liu YF, Yeh YH, Su SC, Chen YC, Chen MK, Yang SF
  Ann Surg Oncol. 2010
  PubMed ID: 20119675
   
  
• Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis.
  Pathak S, D'Souza R, Ankolkar M, Gaonkar R, Balasinor NH
  Mol Cell Endocrinol. 2010
  PubMed ID: 19683557
   
  
• Igf2 Gene Variants and Risk of Hypertension in Obese Children and Adolescents.
  Felicia Faienza M, Santoro N, Lauciello R, Calabrò R, Giordani L, Di Salvo G, Ventura A, Delvecchio M, Perrone L, Miraglia Del Giudice E, Cavallo L
  Pediatr Res. 2010
  PubMed ID: 20057340
   
  
• CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.
  Lee DH, Singh P, Tsai SY, Oates N, Spalla A, Spalla C, Brown L, Rivas G, Larson G, Rauch TA, Pfeifer GP, Szabó PE
  PLoS Genet. 2010
  PubMed ID: 21124827
   
  
• Complete biallelic insulation at the H19/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality.
  Lee DH, Singh P, Tsark WM, Szabó PE
  PLoS One. 2010
  PubMed ID: 20838620
   
  
• Inter- and intra-individual variation in allele-specific DNA methylation and gene expression in children conceived using assisted reproductive technology.
  Turan N, Katari S, Gerson LF, Chalian R, Foster MW, Gaughan JP, Coutifaris C, Sapienza C
  PLoS Genet. 2010
  PubMed ID: 20661447
   
  
• DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response.
  Dejeux E, Rønneberg JA, Solvang H, Bukholm I, Geisler S, Aas T, Gut IG, Børresen-Dale AL, Lønning PE, Kristensen VN, Tost J
  Mol Cancer. 2010
  PubMed ID: 20338046
   
  
• Postnatal survival of mice with maternal duplication of distal chromosome 7 induced by a Igf2/H19 imprinting control region lacking insulator function.
  Han L, Szabó PE, Mann JR
  PLoS Genet. 2010
  PubMed ID: 20062522
   
  
• Frequent aberrant methylation of the imprinted IGF2/H19 locus and LINE1 hypomethylation in ovarian carcinoma.
  Dammann RH, Kirsch S, Schagdarsurengin U, Dansranjavin T, Gradhand E, Schmitt WD, Hauptmann S
  Int J Oncol. 2010
  PubMed ID: 19956846
   
  
• The imprinted Phlda2 gene regulates extraembryonic energy stores.
  Tunster SJ, Tycko B, John RM
  Mol Cell Biol. 2010
  PubMed ID: 19884348
   
  
• Maternally-inherited Grb10 reduces placental size and efficiency.
  Charalambous M, Cowley M, Geoghegan F, Smith FM, Radford EJ, Marlow BP, Graham CF, Hurst LD, Ward A
  Dev Biol. 2010
  PubMed ID: 19833122
   
  
• Specific epigenetic alterations of IGF2-H19 locus in spermatozoa from infertile men.
  Boissonnas CC, Abdalaoui HE, Haelewyn V, Fauque P, Dupont JM, Gut I, Vaiman D, Jouannet P, Tost J, Jammes H
  Eur J Hum Genet. 2010
  PubMed ID: 19584898
   
  
• Integrative predictive model of coronary artery calcification in atherosclerosis.
  McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
  Circulation. 2009
  PubMed ID: 19948975
   
  
• Response of IGF and IL-6 to ovarian stimulation in PCOS and normal women.
  Liang FJ, Wu XK, Qu JW, Ke L, Sun J, Wang Y
  Syst Biol Reprod Med. 2009
  PubMed ID: 19938957
   
  
• bFGF enhances the IGFs-mediated pluripotent and differentiation potentials in multipotent stem cells.
  Park SB, Yu KR, Jung JW, Lee SR, Roh KH, Seo MS, Park JR, Kang SK, Lee YS, Kang KS
  Growth Factors. 2009
  PubMed ID: 19919531
   
  
• Loss of imprinting of the insulin-like growth factor II (IGF2) gene in esophageal normal and adenocarcinoma tissues.
  Zhao R, DeCoteau JF, Geyer CR, Gao M, Cui H, Casson AG
  Carcinogenesis. 2009
  PubMed ID: 19843644
   
  
• Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.
  Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K
  Blood. 2009
  PubMed ID: 19794138
   
  
• CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis.
  Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S
  Exp Cell Res. 2009
  PubMed ID: 19769965
   
  
• Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
  Tkatchenko TV, Moreno-Rodriguez RA, Conway SJ, Molkentin JD, Markwald RR, Tkatchenko AV
  Physiol Genomics. 2009
  PubMed ID: 19723774
   
  
• Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.
  Nativio R, Wendt KS, Ito Y, Huddleston JE, Uribe-Lewis S, Woodfine K, Krueger C, Reik W, Peters JM, Murrell A
  PLoS Genet. 2009
  PubMed ID: 19956766
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
  PubMed ID: 19913121
   
  
• Enrichment of glycopeptides for glycan structure and attachment site identification.
  Nilsson J, Rüetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G
  Nat Methods. 2009
  PubMed ID: 19838169
   
  
• Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats.
  Van Mieghem T, van Bree R, Van Herck E, Deprest J, Verhaeghe J
  Am J Physiol Regul Integr Comp Physiol. 2009
  PubMed ID: 19776249
   
  
• Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study.
  Corpeleijn E, Petersen L, Holst C, Saris WH, Astrup A, Langin D, Macdonald I, Martinez JA, Oppert JM, Polak J, Pedersen O, Froguel P, Arner P, Sørensen TI, Blaak EE
  Obesity (Silver Spring). 2009
  PubMed ID: 19876004
   
  
• Decreased motoneuron survival in Igf2 null mice after sciatic nerve transection.
  Silva D, Dikkes P, Barnes M, Lopez MF
  Neuroreport. 2009
  PubMed ID: 19738502
   
  
• Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
  Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF
  Nat Genet. 2009
  PubMed ID: 19767753
   
  
• H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.
  Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forné T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L
  Development. 2009
  PubMed ID: 19762426
   
  
• High frequency of loss of allelic integrity at Wilms' tumor suppressor gene-1 locus in advanced breast tumors associated with aggressiveness of the tumor.
  Gupta S, Joshi K, Wig JD, Arora SK
  Indian J Cancer. 2009
  PubMed ID: 19749460
   
  
• Hypomethylation of the P3 promoter is associated with up-regulation of IGF2 expression in human osteosarcoma.
  Li Y, Meng G, Huang L, Guo QN
  Hum Pathol. 2009
  PubMed ID: 19427670
   
  
• [VIGILIN involves in regulation of imprinting gene IGF2 and H19 in human hepatocellular carcinoma cell]
  Ge YJ, Xie XY, Yang B, Chai XJ, Zhang YC, Qin Y
  Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
  PubMed ID: 19950580
   
  
• Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.
  Newman J, Cohen EH, Cosgrove L, Kopacz K, Dransfield DT, Adams TE, Peat TS
  Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009
  PubMed ID: 19724140
   
  
• MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.
  Carter EJ, Cosgrove RA, Gonzalez I, Eisemann JH, Lovett FA, Cobb LJ, Pell JM
  J Cell Sci. 2009
  PubMed ID: 19654213
   
  
• Parent-of-origin specific linkage and association of the IGF2 gene region with birth weight and adult metabolic risk factors.
  Souren NY, Paulussen AD, Steyls A, Loos RJ, Brandao RD, Gielen M, Smeets HJ, Beunen G, Fagard R, Derom C, Vlietinck R, Geraedts JP, Zeegers MP
  Int J Obes (Lond). 2009
  PubMed ID: 19546867
   
  
• Hypermethylation of the IGF2 differentially methylated region 2 is a specific event in insulinomas leading to loss-of-imprinting and overexpression.
  Dejeux E, Olaso R, Dousset B, Audebourg A, Gut IG, Terris B, Tost J
  Endocr Relat Cancer. 2009
  PubMed ID: 19502451
   
  
• Effect of nicotine exposure during pregnancy and lactation on maternal, fetal, and postnatal rat IGF-II profile.
  Gruslin A, Cesta CE, Bell M, Qing Qiu, Petre MA, Holloway AC
  Reprod Sci. 2009
  PubMed ID: 19494366
   
  
• Identification of genes expressed preferentially in the developing peripheral margin of the optic cup.
  Trimarchi JM, Cho SH, Cepko CL
  Dev Dyn. 2009
  PubMed ID: 19449303
   
  
• Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
  Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
  Eur Urol. 2009
  PubMed ID: 19692168
   
  
• Endostatin, placental growth factor, and fibroblast growth factors-1 and -2 in the sera of patients with primary osteosarcomas.
  Babkina IV, Osipov DA, Solovyov YN, Bulycheva IV, Machak GN, Aliev MD, Kushlinsky NE
  Bull Exp Biol Med. 2009
  PubMed ID: 20027339
   
  
• Paternal allele of IGF2 gene haplotype CTG is associated with fetal and placental growth in Japanese.
  Nagaya K, Makita Y, Taketazu G, Okamoto T, Nakamura E, Hayashi T, Fujieda K
  Pediatr Res. 2009
  PubMed ID: 19390492
   
  
• PTEN identified as important risk factor of chronic obstructive pulmonary disease.
  Hosgood HD, Menashe I, He X, Chanock S, Lan Q
  Respir Med. 2009
  PubMed ID: 19625176
   
  
• [Study on genomic imprinting of IGF2 in breast cancer].
  Yang R, Wang Y, Zhu X, Gao X
  Wei Sheng Yan Jiu. 2009
  PubMed ID: 19689072
   
  
• Insulin-like growth factor-II methylation status in lymphocyte DNA and colon cancer risk in the Northern Sweden Health and Disease cohort.
  Kaaks R, Stattin P, Villar S, Poetsch AR, Dossus L, Nieters A, Riboli E, Palmqvist R, Hallmans G, Plass C, Friesen MD
  Cancer Res. 2009
  PubMed ID: 19549920
   
  
• Aberrant epigenetic modifications in the CTCF binding domain of the IGF2/H19 gene in prostate cancer compared with benign prostate hyperplasia.
  Paradowska A, Fenic I, Konrad L, Sturm K, Wagenlehner F, Weidner W, Steger K
  Int J Oncol. 2009
  PubMed ID: 19513555
   
  
• Expression of insulin-like growth factor 2 in mesenchymal neoplasms.
  Steigen SE, Schaeffer DF, West RB, Nielsen TO
  Mod Pathol. 2009
  PubMed ID: 19407853
   
  
• Csf2 null mutation alters placental gene expression and trophoblast glycogen cell and giant cell abundance in mice.
  Sferruzzi-Perri AN, Macpherson AM, Roberts CT, Robertson SA
  Biol Reprod. 2009
  PubMed ID: 19228596
   
  
• Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk.
  Lagiou P, Hsieh CC, Lipworth L, Samoli E, Okulicz W, Troisi R, Xu B, Hall P, Ekbom A, Adami HO, Trichopoulos D
  Br J Cancer. 2009
  PubMed ID: 19417744
   
  
• Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy: possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair.
  Sireesha M, Sambasivan V, Kumar VK, Radha S, Raj AY, Qurratulain H
  J Diabetes. 2009
  PubMed ID: 20929508
   
  
• Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.
  Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, Banerjee-Basu S, Baron-Cohen S
  Autism Res. 2009
  PubMed ID: 19598235
   
  
• Homocysteine harasses the imprinting expression of IGF2 and H19 by demethylation of differentially methylated region between IGF2/H19 genes.
  Li L, Xie J, Zhang M, Wang S
  Acta Biochim Biophys Sin (Shanghai). 2009
  PubMed ID: 19499149
   
  
• Selective response to insulin versus insulin-like growth factor-I and -II and up-regulation of insulin receptor splice variant B in the differentiated mouse mammary epithelium.
  Berlato C, Doppler W
  Endocrinology. 2009
  PubMed ID: 19246539
   
  
• Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas.
  Soon PS, Gill AJ, Benn DE, Clarkson A, Robinson BG, McDonald KL, Sidhu SB
  Endocr Relat Cancer. 2009
  PubMed ID: 19218281
   
  
• IGF system in children with congenital disorders of glycosylation.
  Miller BS, Khosravi MJ, Patterson MC, Conover CA
  Clin Endocrinol (Oxf). 2009
  PubMed ID: 19207313
   
  
• A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
  Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
  J Bone Miner Res. 2009
  PubMed ID: 19453261
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• [Combined analyses of paraoxonase-1 and IGF-2 polymorphism in polycystic ovary syndrome]
  Knebel B, Janssen OE, Hahn S, Nitzgen U, Jacob S, Haas J, Mack S, Müller-Wieland D, Kotzka J
  Dtsch Med Wochenschr. 2009
  PubMed ID: 19421925
   
  
• Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
  Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
  Environ Mol Mutagen. 2009
  PubMed ID: 19170196
   
  
• Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss.
  Pathak S, Kedia-Mokashi N, Saxena M, D'Souza R, Maitra A, Parte P, Gill-Sharma M, Balasinor N
  Fertil Steril. 2009
  PubMed ID: 18778817
   
  
• Peptide concentrations and mRNA expression of IGF-I, IGF-II and IGFBP-3 in breast cancer and their associations with disease characteristics.
  Mu L, Katsaros D, Wiley A, Lu L, de la Longrais IA, Smith S, Khubchandani S, Sochirca O, Arisio R, Yu H
  Breast Cancer Res Treat. 2009
  PubMed ID: 18481170
   
  
• Human longevity and 11p15.5: a study in 1321 centenarians.
  Lescai F, Blanché H, Nebel A, Beekman M, Sahbatou M, Flachsbart F, Slagboom E, Schreiber S, Sorbi S, Passarino G, Franceschi C
  Eur J Hum Genet. 2009
  PubMed ID: 19367319
   
  
• Determination of genetic predisposition to patent ductus arteriosus in preterm infants.
  Dagle JM, Lepp NT, Cooper ME, Schaa KL, Kelsey KJ, Orr KL, Caprau D, Zimmerman CR, Steffen KM, Johnson KJ, Marazita ML, Murray JC
  Pediatrics. 2009
  PubMed ID: 19336370
   
  
• Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growth.
  Rezgui D, Williams C, Savage SA, Prince SN, Zaccheo OJ, Jones EY, Crump MP, Hassan AB
  J Mol Endocrinol. 2009
  PubMed ID: 19208780
   
  
• Effects of different CMV-heat-inactivation-methods on growth factors in human breast milk.
  Goelz R, Hihn E, Hamprecht K, Dietz K, Jahn G, Poets C, Elmlinger M
  Pediatr Res. 2009
  PubMed ID: 19127217
   
  
• Diagnostic and prognostic role of the insulin growth factor pathway members insulin-like growth factor-II and insulin-like growth factor binding protein-3 in serous effusions.
  Slipicevic A, Øy GF, Askildt IC, Holth A, Hellesylt E, Flørenes VA, Davidson B
  Hum Pathol. 2009
  PubMed ID: 19121847
   
  
• An extensive genetic program occurring during postnatal growth in multiple tissues.
  Finkielstain GP, Forcinito P, Lui JC, Barnes KM, Marino R, Makaroun S, Nguyen V, Lazarus JE, Nilsson O, Baron J
  Endocrinology. 2009
  PubMed ID: 19036884
   
  
• Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development.
  Sultana DA, Tomita S, Hamada M, Iwanaga Y, Kitahama Y, Khang NV, Hirai S, Ohigashi I, Nitta S, Amagai T, Takahashi S, Takahama Y
  Blood. 2009
  PubMed ID: 19164599
   
  
• The chaperone activity of GRP94 toward insulin-like growth factor II is necessary for the stress response to serum deprivation.
  Ostrovsky O, Ahmed NT, Argon Y
  Mol Biol Cell. 2009
  PubMed ID: 19158397
   
  
• Epigenetic mutations of the imprinted IGF2-H19 domain in Silver-Russell syndrome (SRS): results from a large cohort of patients with SRS and SRS-like phenotypes.
  Bartholdi D, Krajewska-Walasek M, Ounap K, Gaspar H, Chrzanowska KH, Ilyana H, Kayserili H, Lurie IW, Schinzel A, Baumer A
  J Med Genet. 2009
  PubMed ID: 19066168
   
  
• Identification of Igf2, Igfbp2 and Enpp2 as estrogen-responsive genes in rat hippocampus.
  Takeo C, Ikeda K, Horie-Inoue K, Inoue S
  Endocr J. 2009
  PubMed ID: 18946176
   
  
• Expression of insulin-like growth factor pathway proteins in rhabdomyosarcoma: IGF-2 expression is associated with translocation-negative tumors.
  Makawita S, Ho M, Durbin AD, Thorner PS, Malkin D, Somers GR
  Pediatr Dev Pathol. 2009
  PubMed ID: 18788888
   
  
• Enhancement of AG1024-induced H9c2 cardiomyoblast cell apoptosis via the interaction of IGF2R with Galpha proteins and its downstream PKA and PLC-beta modulators by IGF-II.
  Chu CH, Huang CY, Lu MC, Lin JA, Tsai FJ, Tsai CH, Chu CY, Kuo WH, Chen LM, Chen LY
  Chin J Physiol. 2009
  PubMed ID: 19764351
   
  
• Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene.
  Cruz-Correa M, Zhao R, Oviedo M, Bernabe RD, Lacourt M, Cardona A, Lopez-Enriquez R, Wexner S, Cuffari C, Hylind L, Platz E, Cui H, Feinberg AP, Giardiello FM
  Epigenetics. 2009
  PubMed ID: 19242102
   
  
• The Igf2/H19 imprinting control region exhibits sequence-specific and cell-type-dependent DNA methylation-mediated repression.
  Chen Y, Dhupelia A, Schoenherr CJ
  Nucleic Acids Res. 2009
  PubMed ID: 19074953
   
  
• IGF2 modulates the microenvironment for osteoclastogenesis.
  Nakao K, Aoyama M, Fukuoka H, Fujita M, Miyazawa K, Asai K, Goto S
  Biochem Biophys Res Commun. 2009
  PubMed ID: 19056348
   
  
• Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child.
  Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, Lindemans J, Siebel C, Steegers EA, Slagboom PE, Heijmans BT
  PLoS One. 2009
  PubMed ID: 19924280
   
  
• Loss of imprinting of insulin-like growth factor 2 is associated with increased risk of lymph node metastasis and gastric corpus cancer.
  Lu Y, Lu P, Zhu Z, Xu H, Zhu X
  J Exp Clin Cancer Res. 2009
  PubMed ID: 19737423
   
  
• Levels of insulin-like growth factors and their receptors in placenta in relation to macrosomia.
  Jiang H, Xun P, Luo G, Wang Q, Cai Y, Zhang Y, Yu B
  Asia Pac J Clin Nutr. 2009
  PubMed ID: 19713175
   
  
• A novel combination of factors, termed SPIE, which promotes dopaminergic neuron differentiation from human embryonic stem cells.
  Vazin T, Becker KG, Chen J, Spivak CE, Lupica CR, Zhang Y, Worden L, Freed WJ
  PLoS One. 2009
  PubMed ID: 19672298
   
  
• Tissue markers of hypoglycemia: insulin growth factor-II and E-domain of proinsulin growth factor-II expression in solitary fibrous tumor of the pleura.
  Stojsic J, Aiba M, Milenkovic B, Jovanovic D
  J BUON. 2009
  PubMed ID: 19365888
   
  
• The up-regulation of KCC1 gene expression in cervical cancer cells by IGF-II through the ERK1/2MAPK and PI3K/AKT pathways and its significance.
  Zhang S, Wu X, Jiang T, Lu Y, Ma L, Liang M, Sun X
  Eur J Gynaecol Oncol. 2009
  PubMed ID: 19317253
   
  
• Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor.
  Riccio A, Sparago A, Verde G, De Crescenzo A, Citro V, Cubellis MV, Ferrero GB, Silengo MC, Russo S, Larizza L, Cerrato F
  Endocr Dev. 2009
  PubMed ID: 19293570
   
  
• Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer.
  Mavaddat N, Dunning AM, Ponder BA, Easton DF, Pharoah PD
  Cancer Epidemiol Biomarkers Prev. 2009
  PubMed ID: 19124506
   
  
• Endothelial progenitor cell homing: prominent role of the IGF2-IGF2R-PLCbeta2 axis.
  Maeng YS, Choi HJ, Kwon JY, Park YW, Choi KS, Min JK, Kim YH, Suh PG, Kang KS, Won MH, Kim YM, Kwon YG
  Blood. 2009
  PubMed ID: 18832656
   
  
• Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period.
  Zakaria R, Rajikin MH, Yaacob NS, Nor NM
  Acta Histochem. 2009
  PubMed ID: 18676006
   
  
• Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma.
  Honda S, Arai Y, Haruta M, Sasaki F, Ohira M, Yamaoka H, Horie H, Nakagawara A, Hiyama E, Todo S, Kaneko Y
  Br J Cancer. 2008
  PubMed ID: 19034281
   
  
• Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
  Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 19064572
   
  
• Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer.
  Suzuki H, Li Y, Dong X, Hassan MM, Abbruzzese JL, Li D
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 19064563
   
  
• Global gene expression analysis of cranial neural tubes in embryos of diabetic mice.
  Jiang B, Kumar SD, Loh WT, Manikandan J, Ling EA, Tay SS, Dheen ST
  J Neurosci Res. 2008
  PubMed ID: 18655203
   
  
• Persistent epigenetic differences associated with prenatal exposure to famine in humans.
  Heijmans BT, Tobi EW, Stein AD, Putter H, Blauw GJ, Susser ES, Slagboom PE, Lumey LH
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18955703
   
  
• Recurrence of urothelial carcinoma of the bladder: a role for insulin-like growth factor-II loss of imprinting and cytoplasmic E-cadherin immunolocalization.
  Gallagher EM, O'Shea DM, Fitzpatrick P, Harrison M, Gilmartin B, Watson JA, Clarke T, Leonard MO, McGoldrick A, Meehan M, Watson C, Furlong F, O'Kelly P, Fitzpatrick JM, Dervan PA, O'Grady A, Kay EW, McCann A
  Clin Cancer Res. 2008
  PubMed ID: 18980977
   
  
• Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice.
  Corcoran RB, Bachar Raveh T, Barakat MT, Lee EY, Scott MP
  Cancer Res. 2008
  PubMed ID: 18974121
   
  
• A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression.
  Berteaux N, Aptel N, Cathala G, Genton C, Coll J, Daccache A, Spruyt N, Hondermarck H, Dugimont T, Curgy JJ, Forné T, Adriaenssens E
  Mol Cell Biol. 2008
  PubMed ID: 18794369
   
  
• Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene.
  Murphy R, Baptista J, Holly J, Umpleby AM, Ellard S, Harries LW, Crolla J, Cundy T, Hattersley AT
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18728168
   
  
• Elevated free IGF2 levels in localized, early-stage breast cancer in women.
  Espelund U, Cold S, Frystyk J, Ørskov H, Flyvbjerg A
  Eur J Endocrinol. 2008
  PubMed ID: 18719053
   
  
• Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.
  Coan PM, Fowden AL, Constancia M, Ferguson-Smith AC, Burton GJ, Sibley CP
  J Physiol. 2008
  PubMed ID: 18755750
   
  
• High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression are not related to clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation.
  Rosati R, Cerrato F, Doghman M, Pianovski MA, Parise GA, Custódio G, Zambetti GP, Ribeiro RC, Riccio A, Figueiredo BC, Lalli E
  Cancer Genet Cytogenet. 2008
  PubMed ID: 18786438
   
  
• Neuraminidase-1, a subunit of the cell surface elastin receptor, desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2.
  Hinek A, Bodnaruk TD, Bunda S, Wang Y, Liu K
  Am J Pathol. 2008
  PubMed ID: 18772331
   
  
• Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
  Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
  Carcinogenesis. 2008
  PubMed ID: 18676680
   
  
• CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex 2 intrachromosomal loop.
  Li T, Hu JF, Qiu X, Ling J, Chen H, Wang S, Hou A, Vu TH, Hoffman AR
  Mol Cell Biol. 2008
  PubMed ID: 18662993
   
  
• Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking.
  Engel N, Raval AK, Thorvaldsen JL, Bartolomei SM
  Hum Mol Genet. 2008
  PubMed ID: 18617529
   
  
• Molecular and clinical findings and their correlations in Silver-Russell syndrome: implications for a positive role of IGF2 in growth determination and differential imprinting regulation of the IGF2-H19 domain in bodies and placentas.
  Yamazawa K, Kagami M, Nagai T, Kondoh T, Onigata K, Maeyama K, Hasegawa T, Hasegawa Y, Yamazaki T, Mizuno S, Miyoshi Y, Miyagawa S, Horikawa R, Matsuoka K, Ogata T
  J Mol Med. 2008
  PubMed ID: 18607558
   
  
• Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice.
  López-García C, López-Contreras AJ, Cremades A, Castells MT, Marín F, Schreiber F, Peñafiel R
  Endocrinology. 2008
  PubMed ID: 18583422
   
  
• Differential effects of human chorionic gonadotropin and decidualization on insulin-like growth factors-I and -II in human endometrial stromal cells.
  Fluhr H, Carli S, Deperschmidt M, Wallwiener D, Zygmunt M, Licht P
  Fertil Steril. 2008
  PubMed ID: 18022169
   
  
• Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma.
  Couvert P, Carrié A, Pariès J, Vaysse J, Miroglio A, Kerjean A, Nahon P, Chelly J, Trinchet JC, Beaugrand M, Ganne-Carrié N
  World J Gastroenterol. 2008
  PubMed ID: 18803353
   
  
• HIF-1 alpha: a key survival factor for serum-deprived prostate cancer cells.
  Thomas R, Kim MH
  Prostate. 2008
  PubMed ID: 18563715
   
  
• IGFBP-5 regulates muscle cell differentiation by binding to IGF-II and switching on the IGF-II auto-regulation loop.
  Ren H, Yin P, Duan C
  J Cell Biol. 2008
  PubMed ID: 18762576
   
  
• Genetic alterations in colorectal cancers with demethylation of insulin-like growth factor II.
  Ohta M, Sugimoto T, Seto M, Mohri D, Asaoka Y, Tada M, Tanaka Y, Yamaji Y, Kanai F, Kawabe T, Omata M
  Hum Pathol. 2008
  PubMed ID: 18619647
   
  
• Insulin and insulin-like growth factor resistance in alcoholic neurodegeneration.
  de la Monte SM, Tong M, Cohen AC, Sheedy D, Harper C, Wands JR
  Alcohol Clin Exp Res. 2008
  PubMed ID: 18616667
   
  
• Expression of insulin-like growth factor-II and its receptor in pediatric and adult adrenocortical tumors.
  Almeida MQ, Fragoso MC, Lotfi CF, Santos MG, Nishi MY, Costa MH, Lerario AM, Maciel CC, Mattos GE, Jorge AA, Mendonca BB, Latronico AC
  J Clin Endocrinol Metab. 2008
  PubMed ID: 18611974
   
  
• Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma.
  Grbesa I, Marinkovic M, Ivkic M, Kruslin B, Novak-Kujundzic R, Pegan B, Bogdanovic O, Bedekovic V, Gall-Troselj K
  J Mol Med. 2008
  PubMed ID: 18604514
   
  
• Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer.
  Ito Y, Koessler T, Ibrahim AE, Rai S, Vowler SL, Abu-Amero S, Silva AL, Maia AT, Huddleston JE, Uribe-Lewis S, Woodfine K, Jagodic M, Nativio R, Dunning A, Moore G, Klenova E, Bingham S, Pharoah PD, Brenton JD, Beck S, Sandhu MS, Murrell A
  Hum Mol Genet. 2008
  PubMed ID: 18541649
   
  
• Elevated serum levels of IGF-binding protein 2 in patients with non-seminomatous germ cell cancer: correlation with tumor markers alpha-fetoprotein and human chorionic gonadotropin.
  Fottner C, Sattarova S, Hoffmann K, Spöttl G, Weber MM
  Eur J Endocrinol. 2008
  PubMed ID: 18524796
   
  
• The H19 locus acts in vivo as a tumor suppressor.
  Yoshimizu T, Miroglio A, Ripoche MA, Gabory A, Vernucci M, Riccio A, Colnot S, Godard C, Terris B, Jammes H, Dandolo L
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18719115
   
  
• Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
  Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I
  Mol Cell. 2008
  PubMed ID: 18722179
   
  
• Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate.
  Fu VX, Dobosy JR, Desotelle JA, Almassi N, Ewald JA, Srinivasan R, Berres M, Svaren J, Weindruch R, Jarrard DF
  Cancer Res. 2008
  PubMed ID: 18701505
   
  
• [Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro]
  Penkov LI, Kondrakhina MS, Mironova OV, Platonov ES
  Genetika. 2008
  PubMed ID: 18825967
   
  
• Alterations in methylation and expression levels of imprinted genes H19 and Igf2 in the fetuses of diabetic mice.
  Shao WJ, Tao LY, Gao C, Xie JY, Zhao RQ
  Comp Med. 2008
  PubMed ID: 18724775
   
  
• Abnormal expression of insulin-like growth factor-II and its dynamic quantitative analysis at different stages of hepatocellular carcinoma development.
  Qiu LW, Yao DF, Zong L, Lu YY, Huang H, Wu W, Wu XH
  Hepatobiliary Pancreat Dis Int. 2008
  PubMed ID: 18693177
   
  
• Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians.
  Smits G, Mungall AJ, Griffiths-Jones S, Smith P, Beury D, Matthews L, Rogers J, Pask AJ, Shaw G, VandeBerg JL, McCarrey JR, SAVOIR Consortium, Renfree MB, Reik W, Dunham I
  Nat Genet. 2008
  PubMed ID: 18587395
   
  
• Genetic variation in insulin-like growth factors and brain tumor risk.
  Lönn S, Rothman N, Shapiro WR, Fine HA, Selker RG, Black PM, Loeffler JS, Hutchinson AA, Inskip PD
  Neuro Oncol. 2008
  PubMed ID: 18562769
   
  
• Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities.
  Haruta M, Arai Y, Sugawara W, Watanabe N, Honda S, Ohshima J, Soejima H, Nakadate H, Okita H, Hata J, Fukuzawa M, Kaneko Y
  Genes Chromosomes Cancer. 2008
  PubMed ID: 18464243
   
  
• A methyl-deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate.
  Dobosy JR, Fu VX, Desotelle JA, Srinivasan R, Kenowski ML, Almassi N, Weindruch R, Svaren J, Jarrard DF
  Prostate. 2008
  PubMed ID: 18459101
   
  
• Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism.
  Umekawa T, Sugiyama T, Kihira T, Murabayashi N, Zhang L, Nagao K, Kamimoto Y, Ma N, Yodoi J, Sagawa N
  Endocrinology. 2008
  PubMed ID: 18450962
   
  
• Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis.
  Nussbaum T, Samarin J, Ehemann V, Bissinger M, Ryschich E, Khamidjanov A, Yu X, Gretz N, Schirmacher P, Breuhahn K
  Hepatology. 2008
  PubMed ID: 18537183
   
  
• An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs.
  Lui JC, Finkielstain GP, Barnes KM, Baron J
  Am J Physiol Regul Integr Comp Physiol. 2008
  PubMed ID: 18448610
   
  
• Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas.
  Imaoka T, Yamashita S, Nishimura M, Kakinuma S, Ushijima T, Shimada Y
  J Radiat Res (Tokyo). 2008
  PubMed ID: 18421211
   
  
• Abnormal Igf2 gene in Prague hereditary hypertriglyceridemic rats: its relation to blood pressure and plasma lipids.
  Kadlecová M, Dobesová Z, Zicha J, Kunes J
  Mol Cell Biochem. 2008
  PubMed ID: 18418699
   
  
• Insulin-like growth factor (IGF) 1 and 2 help to predict disease outcome in GIST patients.
  Braconi C, Bracci R, Bearzi I, Bianchi F, Sabato S, Mandolesi A, Belvederesi L, Cascinu S, Valeri N, Cellerino R
  Ann Oncol. 2008
  PubMed ID: 18372285
   
  
• Vitamin C suppresses proliferation of the human melanoma cell SK-MEL-2 through the inhibition of cyclooxygenase-2 (COX-2) expression and the modulation of insulin-like growth factor II (IGF-II) production.
  Lee SK, Kang JS, Jung da J, Hur DY, Kim JE, Hahm E, Bae S, Kim HW, Kim D, Cho BJ, Cho D, Shin DH, Hwang YI, Lee WJ
  J Cell Physiol. 2008
  PubMed ID: 18297687
   
  
• Genetic Predisposition to Idiopathic Recurrent Spontaneous Abortion: Contribution of Genetic Variations in IGF-2 and H19 Imprinted Genes.
  Ostojić S, Pereza N, Volk M, Kapović M, Peterlin B
  Am J Reprod Immunol. 2008
  PubMed ID: 18573128
   
  
• Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.
  Sutherland G, Mellick G, Newman J, Double KL, Stevens J, Lee L, Rowe D, Silburn P, Halliday GM
  Am J Med Genet B Neuropsychiatr Genet. 2008
  PubMed ID: 18085551
   
  
• Disruption of Krox20-Nab interaction in the mouse leads to peripheral neuropathy with biphasic evolution.
  Desmazières A, Decker L, Vallat JM, Charnay P, Gilardi-Hebenstreit P
  J Neurosci. 2008
  PubMed ID: 18524893
   
  
• Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells.
  Berensztein EB, Baquedano MS, Pepe CM, Costanzo M, Saraco NI, Ponzio R, Rivarola MA, Belgorosky A
  Pediatr Res. 2008
  PubMed ID: 18520331
   
  
• Insulin-like growth factor-II is increased in systemic sclerosis-associated pulmonary fibrosis and contributes to the fibrotic process via Jun N-terminal kinase- and phosphatidylinositol-3 kinase-dependent pathways.
  Hsu E, Feghali-Bostwick CA
  Am J Pathol. 2008
  PubMed ID: 18467708
   
  
• A review of the role of insulin-like growth factor 2 in malignancy and its potential as a modifier of radiation sensitivity.
  Jacobs CI
  Clin Oncol (R Coll Radiol). 2008
  PubMed ID: 18359210
   
  
• A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.
  Qiu X, Vu TH, Lu Q, Ling JQ, Li T, Hou A, Wang SK, Chen HL, Hu JF, Hoffman AR
  Mol Endocrinol. 2008
  PubMed ID: 18356289
   
  
• Synergistic role of Igf2 and Dlk1 in fetal liver development and hematopoiesis in bi-maternal mice.
  Wu Q, Kawahara M, Kono T
  J Reprod Dev. 2008
  PubMed ID: 18344616
   
  
• Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.
  Cerrato F, Sparago A, Verde G, De Crescenzo A, Citro V, Cubellis MV, Rinaldi MM, Boccuto L, Neri G, Magnani C, D'Angelo P, Collini P, Perotti D, Sebastio G, Maher ER, Riccio A
  Hum Mol Genet. 2008
  PubMed ID: 18245780
   
  
• Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice.
  Declercq J, Van Dyck F, Van Damme B, Van de Ven WJ
  Int J Oncol. 2008
  PubMed ID: 18425330
   
  
• Hypomethylated and hypermethylated profiles of H19DMR are associated with the aberrant imprinting of IGF2 and H19 in human hepatocellular carcinoma.
  Wu J, Qin Y, Li B, He WZ, Sun ZL
  Genomics. 2008
  PubMed ID: 18358696
   
  
• Insulin-like growth factor (IGF) binding protein-4 is both a positive and negative regulator of IGF activity in vivo.
  Ning Y, Schuller AG, Conover CA, Pintar JE
  Mol Endocrinol. 2008
  PubMed ID: 18258685
   
  
• Precursor IGF-II (proIGF-II) and mature IGF-II (mIGF-II) induce Bcl-2 And Bcl-X L expression through different signaling pathways in breast cancer cells.
  Singh SK, Moretta D, Almaguel F, De León M, De León DD
  Growth Factors. 2008
  PubMed ID: 18428028
   
  
• IGF2: epigenetic regulation and role in development and disease.
  Chao W, D'Amore PA
  Cytokine Growth Factor Rev. 2008
  PubMed ID: 18308616
   
  
• Role of IGF signaling in olfactory sensory map formation and axon guidance.
  Scolnick JA, Cui K, Duggan CD, Xuan S, Yuan XB, Efstratiadis A, Ngai J
  Neuron. 2008
  PubMed ID: 18367086
   
  
• Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.
  Breuhahn K, Schirmacher P
  World J Gastroenterol. 2008
  PubMed ID: 18350600
   
  
• Mighty is a novel promyogenic factor in skeletal myogenesis.
  Marshall A, Salerno MS, Thomas M, Davies T, Berry C, Dyer K, Bracegirdle J, Watson T, Dziadek M, Kambadur R, Bower R, Sharma M
  Exp Cell Res. 2008
  PubMed ID: 18255059
   
  
• Risk of testicular germ cell tumors and polymorphisms in the insulin-like growth factor genes.
  Chia VM, Sakoda LC, Graubard BI, Rubertone MV, Chanock SJ, Erickson RL, McGlynn KA
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 18349294
   
  
• IGF-2 and FLT-1/VEGF-R1 mRNA levels reveal distinctions and similarities between congenital and common infantile hemangioma.
  Picard A, Boscolo E, Khan ZA, Bartch TC, Mulliken JB, Vazquez MP, Bischoff J
  Pediatr Res. 2008
  PubMed ID: 18287964
   
  
• IGF2/H19 hypomethylation in Silver-Russell syndrome and isolated hemihypoplasia.
  Zeschnigk M, Albrecht B, Buiting K, Kanber D, Eggermann T, Binder G, Gromoll J, Prott EC, Seland S, Horsthemke B
  Eur J Hum Genet. 2008
  PubMed ID: 18159214
   
  
• Forkhead box protein O1 negatively regulates skeletal myocyte differentiation through degradation of mammalian target of rapamycin pathway components.
  Wu AL, Kim JH, Zhang C, Unterman TG, Chen J
  Endocrinology. 2008
  PubMed ID: 18079193
   
  
• PLD regulates myoblast differentiation through the mTOR-IGF2 pathway.
  Yoon MS, Chen J
  J Cell Sci. 2008
  PubMed ID: 18198186
   
  
• Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
  Pan Z, Sikandar S, Witherspoon M, Dizon D, Nguyen T, Benirschke K, Wiley C, Vrana P, Lipkin SM
  Dev Dyn. 2008
  PubMed ID: 18163532
   
  
• CTCF is the master organizer of domain-wide allele-specific chromatin at the H19/Igf2 imprinted region.
  Han L, Lee DH, Szabó PE
  Mol Cell Biol. 2008
  PubMed ID: 18039862
   
  
• G9a histone methyltransferase contributes to imprinting in the mouse placenta.
  Wagschal A, Sutherland HG, Woodfine K, Henckel A, Chebli K, Schulz R, Oakey RJ, Bickmore WA, Feil R
  Mol Cell Biol. 2008
  PubMed ID: 18039842
   
  
• Epigenetic and phenotypic consequences of a truncation disrupting the imprinted domain on distal mouse chromosome 7.
  Oh R, Ho R, Mar L, Gertsenstein M, Paderova J, Hsien J, Squire JA, Higgins MJ, Nagy A, Lefebvre L
  Mol Cell Biol. 2008
  PubMed ID: 18039841
   
  
• Association between small for gestational age and paternally inherited 5' insulin haplotypes.
  Adkins RM, Krushkal J, Klauser CK, Magann EF, Morrison JC, Somes G
  Int J Obes (Lond). 2008
  PubMed ID: 17700581
   
  
• Two distinct mechanisms of silencing by the KvDMR1 imprinting control region.
  Shin JY, Fitzpatrick GV, Higgins MJ
  EMBO J. 2008
  PubMed ID: 18079696
   
  
• Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
  Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
  PLoS ONE. 2008
  PubMed ID: 18636124
   
  
• Temporal changes in insulin-like growth factors I and II and in insulin-like growth factor binding proteins 1, 2, and 3 in human milk.
  Milsom SR, Blum WF, Gunn AJ
  Horm Res. 2008
  PubMed ID: 18259111
   
  
• Prolactin receptor signaling is essential for perinatal brown adipocyte function: a role for insulin-like growth factor-2.
  Viengchareun S, Servel N, Fève B, Freemark M, Lombès M, Binart N
  PLoS ONE. 2008
  PubMed ID: 18253483
   
  
• IGF-I and IGF-II genetic variation and breast cancer risk in Chinese women: results from the Shanghai Breast Cancer Study.
  Deming SL, Ren Z, Cai Q, Shu XO, Wen W, Long JR, Gao YT, Zheng W
  Cancer Epidemiol Biomarkers Prev. 2008
  PubMed ID: 18199734
   
  
• IGFBP5 is a potential regulator of craniofacial skeletogenesis.
  Bobola N, Engist B
  Genesis. 2008
  PubMed ID: 18196601
   
  
• Placental IGF2 expression in normal and intrauterine growth restricted (IUGR) pregnancies.
  Antonazzo P, Alvino G, Cozzi V, Grati FR, Tabano S, Sirchia S, Miozzo M, Cetin I
  Placenta. 2008
  PubMed ID: 17919721
   
  
• Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions.
  Takebayashi S, Tamura T, Matsuoka C, Okano M
  Mol Cell Biol. 2007
  PubMed ID: 17893328
   
  
• Examination of IGF2 and H19 loss of imprinting in bladder cancer.
  Byun HM, Wong HL, Birnstein EA, Wolff EM, Liang G, Yang AS
  Cancer Res. 2007
  PubMed ID: 18006818
   
  
• Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.
  Kawahara M, Wu Q, Ferguson-Smith AC, Kono T
  FEBS Lett. 2007
  PubMed ID: 17959172
   
  
• Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression.
  Kovacheva VP, Mellott TJ, Davison JM, Wagner N, Lopez-Coviella I, Schnitzler AC, Blusztajn JK
  J Biol Chem. 2007
  PubMed ID: 17724018
   
  
• IGF2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration.
  Dikkes P, B Jaffe D, Guo WH, Chao C, Hemond P, Yoon K, Zurakowski D, Lopez MF
  Brain Res. 2007
  PubMed ID: 17870057
   
  
• Upregulation of IGF-2 and IGF-1 receptor expression in oral cancer cell lines.
  Brady G, Crean SJ, Naik P, Kapas S
  Int J Oncol. 2007
  PubMed ID: 17786320
   
  
• Association between paternally inherited haplotypes upstream of the insulin gene and umbilical cord IGF-II levels.
  Adkins RM, Fain JN, Krushkal J, Klauser CK, Magann EF, Morrison JC
  Pediatr Res. 2007
  PubMed ID: 17667841
   
  
• Effect of insulin-like-growth factor and its receptors regarding lung development in fetal mice.
  Nagata K, Masumoto K, Uesugi T, Yamamoto S, Yoshizaki K, Fukumoto S, Nonaka K, Taguchi T
  Pediatr Surg Int. 2007
  PubMed ID: 17653731
   
  
• Rho guanosine 5'-triphosphatases differentially regulate insulin-like growth factor I (IGF-I) receptor-dependent and -independent actions of IGF-II on human trophoblast migration.
  Shields SK, Nicola C, Chakraborty C
  Endocrinology. 2007
  PubMed ID: 17640993
   
  
• Duplication of the paternal IGF2 allele in trisomy 11 and elevated expression levels of IGF2 mRNA in congenital mesoblastic nephroma of the cellular or mixed type.
  Watanabe N, Haruta M, Soejima H, Fukushi D, Yokomori K, Nakadate H, Okita H, Hata JI, Fukuzawa M, Kaneko Y
  Genes Chromosomes Cancer. 2007
  PubMed ID: 17639583
   
  
• Activation of endoproteolytic processing of insulin-like growth factor-II in fetal, early postnatal, and pregnant rats and persistence of circulating levels in postnatal life.
  Qiu Q, Jiang JY, Bell M, Tsang BK, Gruslin A
  Endocrinology. 2007
  PubMed ID: 17628003
   
  
• IGF-II promoter methylation and ovarian cancer prognosis.
  Beeghly AC, Katsaros D, Wiley AL, Rigault de la Longrais IA, Prescott AT, Chen H, Puopolo M, Rutherford TJ, Yu H
  J Cancer Res Clin Oncol. 2007
  PubMed ID: 17569086
   
  
• Severe deficiencies of IGF-I, IGF-II, IGFBP-3, ALS and paradoxically high-normal bone mass in a child with insulin-resistance syndrome (Rabson-Mendenhall type).
  Fowlkes JL, Bunn RC, Coleman HN, Hall B, Reid MC, Thrailkill KM
  Growth Horm IGF Res. 2007
  PubMed ID: 17560154
   
  
• The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
  El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM
  J Biol Chem. 2007
  PubMed ID: 17620336
   
  
• Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4).
  Bachner-Melman R, Lerer E, Zohar AH, Kremer I, Elizur Y, Nemanov L, Golan M, Blank S, Gritsenko I, Ebstein RP
  Am J Med Genet B Neuropsychiatr Genet. 2007
  PubMed ID: 17440932
   
  
• Association of gastric cancer with tyrosine hydroxylase gene polymorphism in a northwestern Chinese population.
  Li ZQ, Yu WP, Xie XD, Li PQ, Guo TK, Zhang WH, An LZ, Wang XL
  Clin Exp Med. 2007
  PubMed ID: 17972051
   
  
• Hepatocellular carcinomas of the albumin SV40 T-antigen transgenic rat display fetal-like re-expression of lgf2 and deregulation of H19.
  Czarny MJ, Babcock K, Baus RM, Manoharan H, Pitot HC
  Mol Carcinog. 2007
  PubMed ID: 17393425
   
  
• IGF-II and IGFBP-2 differentially regulate PTEN in human breast cancer cells.
  Perks CM, Vernon EG, Rosendahl AH, Tonge D, Holly JM
  Oncogene. 2007
  PubMed ID: 17369847
   
  
• IGF-II regulates metastatic properties of choriocarcinoma cells through the activation of the insulin receptor.
  Diaz LE, Chuan YC, Lewitt M, Fernandez-Perez L, Carrasco-Rodríguez S, Sanchez-Gomez M, Flores-Morales A
  Mol Hum Reprod. 2007
  PubMed ID: 17556377
   
  
• Changes in the antioxidant defense and hepatic drug metabolizing enzyme and isoenzyme levels, 8-hydroxydeoxyguanosine formation and expressions of c-raf.1 and insulin-like growth factor II genes during the stages of development of hepatocellular carcinoma
  Mukherjee B, Das T, Ghosh S, Datta S
  Eur J Cancer Prev. 2007
  PubMed ID: 17554210
   
  
• Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.
  Ogino S, Kawasaki T, Kirkner GJ, Kraft P, Loda M, Fuchs CS
  J Mol Diagn. 2007
  PubMed ID: 17591929
   
  
• Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
  Todd JA, Walker NM, Cooper JD, Smyth DJ, Downes K, Plagnol V, Bailey R, Nejentsev S, Field SF, Payne F, Lowe CE, Szeszko JS, Hafler JP, Zeitels L, Yang JH, Vella A, Nutland S, Stevens HE, Schuilenburg H, Coleman G, Maisuria M, Meadows W, Smink LJ, Healy B, Burren OS, Lam AA, Ovington NR, Allen J, Adlem E, Leung HT, Wallace C, Howson JM, Guja C, Ionescu-Tîrgovişte C, Genetics of Type 1 Diabetes in Finland, Simmonds MJ, Heward JM, Gough SC, Wellcome Trust Case Control Consortium, Dunger DB, Wicker LS, Clayton DG
  Nat Genet. 2007
  PubMed ID: 17554260
   
  
• Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women.
  Heude B, Ong KK, Luben R, Wareham NJ, Sandhu MS
  J Clin Endocrinol Metab. 2007
  PubMed ID: 17488802
   
  
• A novel binding site for the human insulin-like growth factor-II (IGF-II)/mannose 6-phosphate receptor on IGF-II.
  Delaine C, Alvino CL, McNeil KA, Mulhern TD, Gauguin L, De Meyts P, Jones EY, Brown J, Wallace JC, Forbes BE
  J Biol Chem. 2007
  PubMed ID: 17475626
   
  
• Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency.
  Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A
  Genes Dev. 2007
  PubMed ID: 17473174
   
  
• IGF-II gene region polymorphisms related to exertional muscle damage.
  Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E, Clarkson PM
  J Appl Physiol. 2007
  PubMed ID: 17289909
   
  
• [The role of insulin-like growth factor-2 gene differentially methylated regions in TCDD-induced malformation]
  Wang J, Zhao YY, Liu H, Li YH, Li GY, Sun KL, Guo L
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
  PubMed ID: 17407073
   
  
• Assessment and disease comparisons of hybrid developmental defects.
  Duselis AR, Vrana PB
  Hum Mol Genet. 2007
  PubMed ID: 17339267
   
  
• Effects of maternal undernutrition on lung growth and insulin-like growth factor system expression in rat offspring.
  Chen CM, Wang LF, Lang YD
  Acta Paediatr Taiwan. 2007
  PubMed ID: 17626604
   
  
• Insulin-like growth factor 2 (IGF2) and IGF2 receptor gene variants are associated with fetal growth.
  Kaku K, Osada H, Seki K, Sekiya S
  Acta Paediatr. 2007
  PubMed ID: 17407457
   
  
• Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus.
  Heijmans BT, Kremer D, Tobi EW, Boomsma DI, Slagboom PE
  Hum Mol Genet. 2007
  PubMed ID: 17339271
   
  
• Paternally inherited submicroscopic duplication at 11p15.5 implicates insulin-like growth factor II in overgrowth and Wilms' tumorigenesis.
  Algar EM, St Heaps L, Darmanian A, Dagar V, Prawitt D, Peters GB, Collins F
  Cancer Res. 2007
  PubMed ID: 17325026
   
  
• Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma.
  Soroceanu L, Kharbanda S, Chen R, Soriano RH, Aldape K, Misra A, Zha J, Forrest WF, Nigro JM, Modrusan Z, Feuerstein BG, Phillips HS
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360667
   
  
• Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain.
  Dikkes P, Hawkes C, Kar S, Lopez MF
  Brain Res. 2007
  PubMed ID: 17184742
   
  
• [Loss of imprinting of IGF2 in cord blood of newborns of Chinese Han population]
  Dai YM, Hu YL, Wang ZQ, Li J
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007
  PubMed ID: 17285535
   
  
• Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.
  Shen J, Liu J, Xie Y, Diwan BA, Waalkes MP
  Toxicol Sci. 2007
  PubMed ID: 17077188
   
  
• Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner.
  Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, Ezaki O, Ogawa Y
  FEBS Lett. 2007
  PubMed ID: 17182038
   
  
• Associations of blood levels of insulin-like growth factor (IGF)-I, IGF-II and IGF binding protein (IGFBP)-3 in schizophrenic Arab subjects.
  Akanji AO, Ohaeri JU, Al-Shammri SA, Fatania HR
  Clin Chem Lab Med. 2007
  PubMed ID: 17635080
   
  
• Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation.
  Wang Y, Zhang M, Middleton FA, Horton JA, Pritchard M, Spadaro JA, Farnum CE, Damron TA
  Cells Tissues Organs. 2007
  PubMed ID: 17630476
   
  
• A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.
  Merrick D, Ting T, Stadler LK, Smith J
  BMC Dev Biol. 2007
  PubMed ID: 17559643
   
  
• Insulin-like growth factors and binding proteins in early milk from mothers of preterm and term infants.
  Elmlinger MW, Hochhaus F, Loui A, Frommer KW, Obladen M, Ranke MB
  Horm Res. 2007
  PubMed ID: 17341887
   
  
• [The aberrant imprinting of insulin-like growth factor II and H19 in human hepatocellular carcinoma]
  Wu J, Qin Y, Li B, He WZ, Sun ZL
  Sichuan Da Xue Xue Bao Yi Xue Ban. 2007
  PubMed ID: 17294726
   
  
• Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.
  Holm PC, Mader MT, Haubst N, Wizenmann A, Sigvardsson M, Götz M
  Mol Cell Neurosci. 2007
  PubMed ID: 17158062
   
  
• Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.
  Colón E, Zaman F, Axelson M, Larsson O, Carlsson-Skwirut C, Svechnikov KV, Söder O
  Endocrinology. 2007
  PubMed ID: 17023532
   
  
• Postnatally elevated levels of insulin-like growth factor (IGF)-II fail to rescue the dwarfism of IGF-I-deficient mice except kidney weight.
  Moerth C, Schneider MR, Renner-Mueller I, Blutke A, Elmlinger MW, Erben RG, Camacho-Hübner C, Hoeflich A, Wolf E
  Endocrinology. 2007
  PubMed ID: 17008389
   
  
• Insulin-like growth factors induce apoptosis as well as proliferation in LIM 1215 colon cancer cells.
  Fu P, Thompson JA, Leeding KS, Bach LA
  J Cell Biochem. 2007
  PubMed ID: 16888814
   
  
• LOI of IGF2 is associated with esophageal cancer and linked to methylation status of IGF2 DMR.
  Xu W, Fan H, He X, Zhang J, Xie W
  J Exp Clin Cancer Res. 2006
  PubMed ID: 17310846
   
  
• Tissue-specific regulation of insulin-like growth factors and insulin-like growth factor binding proteins in male diabetic rats in vivo and in vitro.
  Han HJ, Kang CW, Park SH
  Clin Exp Pharmacol Physiol. 2006
  PubMed ID: 17184497
   
  
• Igf2 deficiency results in delayed lung development at the end of gestation.
  Silva D, Venihaki M, Guo WH, Lopez MF
  Endocrinology. 2006
  PubMed ID: 16959842
   
  
• The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer.
  Han JY, Choi BG, Choi JY, Lee SY, Ju SY
  Lung Cancer. 2006
  PubMed ID: 16935391
   
  
• Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma.
  Tomizawa M, Saisho H
  World J Gastroenterol. 2006
  PubMed ID: 17072986
   
  
• Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.
  El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM
  J Biol Chem. 2006
  PubMed ID: 16926156
   
  
• Control of MyoD function during initiation of muscle differentiation by an autocrine signaling pathway activated by insulin-like growth factor-II.
  Wilson EM, Rotwein P
  J Biol Chem. 2006
  PubMed ID: 16901893
   
  
• Disruption of parental-specific expression of imprinted genes in uniparental fetuses.
  Ogawa H, Wu Q, Komiyama J, Obata Y, Kono T
  FEBS Lett. 2006
  PubMed ID: 16987518
   
  
• [Characteristics of IGF-II gene imprinting in twin placentas]
  Luo YM, Fang Q, Zhuang GL, Liang RC, Liu QL
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
  PubMed ID: 17029194
   
  
• CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.
  Engel N, Thorvaldsen JL, Bartolomei MS
  Hum Mol Genet. 2006
  PubMed ID: 16928784
   
  
• Scarring impedes regeneration at sites of peripheral nerve repair.
  Atkins S, Smith KG, Loescher AR, Boissonade FM, O'Kane S, Ferguson MW, Robinson PP
  Neuroreport. 2006
  PubMed ID: 16951563
   
  
• The essential role of insulin-like growth factor-1 in the intestinal tropic effects of glucagon-like peptide-2 in mice.
  Dubé PE, Forse CL, Bahrami J, Brubaker PL
  Gastroenterology. 2006
  PubMed ID: 16890611
   
  
• The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
  Villuendas G, Botella-Carretero JI, López-Bermejo A, Gubern C, Ricart W, Fernández-Real JM, San Millán JL, Escobar-Morreale HF
  Eur J Endocrinol. 2006
  PubMed ID: 16868148
   
  
• Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation.
  Lee SD, Chu CH, Huang EJ, Lu MC, Liu JY, Liu CJ, Hsu HH, Lin JA, Kuo WW, Huang CY
  Am J Physiol Endocrinol Metab. 2006
  PubMed ID: 16825605
   
  
• IGF2 polymorphisms are associated with hepatitis B virus clearance and hepatocellular carcinoma.
  Kim YJ, Yoon JH, Kim CY, Kim LH, Park BL, Shin HD, Lee HS
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16750516
   
  
• Hypomethylated P4 promoter induces expression of the insulin-like growth factor-II gene in hepatocellular carcinoma in a Chinese population.
  Tang SH, Yang DH, Huang W, Zhou HK, Lu XH, Ye G
  Clin Cancer Res. 2006
  PubMed ID: 16857788
   
  
• IGF-I and IGF-II stimulate directed cell migration of bone-marrow-derived human mesenchymal progenitor cells.
  Fiedler J, Brill C, Blum WF, Brenner RE
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16716263
   
  
• Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
  Watanabe N, Nakadate H, Haruta M, Sugawara W, Sasaki F, Tsunematsu Y, Kikuta A, Fukuzawa M, Okita H, Hata J, Soejima H, Kaneko Y
  Genes Chromosomes Cancer. 2006
  PubMed ID: 16518847
   
  
• Dendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice.
  Hansenne I, Renard-Charlet C, Greimers R, Geenen V
  J Immunol. 2006
  PubMed ID: 16585557
   
  
• Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human.
  Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constância M, Moore GE
  Hum Mol Genet. 2006
  PubMed ID: 16531418
   
  
• Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer.
  Murphy SK, Huang Z, Wen Y, Spillman MA, Whitaker RS, Simel LR, Nichols TD, Marks JR, Berchuck A
  Mol Cancer Res. 2006
  PubMed ID: 16603642
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Loss of imprinting in IGF2 in colorectal carcinoma assessed by microdissection.
  Maenaka S, Hikichi T, Imai MA, Minamoto T, Kawahara E
  Oncol Rep. 2006
  PubMed ID: 16525660
   
  
• Human chromosome 11 DNA sequence and analysis including novel gene identification.
  Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
  Nature. 2006
  PubMed ID: 16554811
   
  
• IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.
  Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S
  Oncogene. 2006
  PubMed ID: 16247461
   
  
• The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer.
  Lu L, Katsaros D, Wiley A, Rigault de la Longrais IA, Risch HA, Puopolo M, Yu H
  Clin Cancer Res. 2006
  PubMed ID: 16489075
   
  
• Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting.
  Harper J, Burns JL, Foulstone EJ, Pignatelli M, Zaina S, Hassan AB
  Cancer Res. 2006
  PubMed ID: 16488992
   
  
• Stochastic imprinting in the progeny of Dnmt3L-/- females.
  Arnaud P, Hata K, Kaneda M, Li E, Sasaki H, Feil R, Kelsey G
  Hum Mol Genet. 2006
  PubMed ID: 16403808
   
  
• Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.
  Thorvaldsen JL, Fedoriw AM, Nguyen S, Bartolomei MS
  Mol Cell Biol. 2006
  PubMed ID: 16449639
   
  
• The expression of insulin-like growth factor and insulin-like growth factor binding protein mRNAs in mouse placenta.
  Carter AM, Nygard K, Mazzuca DM, Han VK
  Placenta. 2006
  PubMed ID: 16338473
   
  
• Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts.
  Govoni KE, Amaar YG, Kramer A, Winter E, Baylink DJ, Mohan S
  Growth Horm IGF Res. 2006
  PubMed ID: 16311053
   
  
• Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.
  Krizhanovsky V, Soreq L, Kliminski V, Ben-Arie N
  J Mol Neurosci. 2006
  PubMed ID: 16679559
   
  
• Imprinted genes, placental development and fetal growth.
  Fowden AL, Sibley C, Reik W, Constancia M
  Horm Res. 2006
  PubMed ID: 16612114
   
  
• Mutagenesis in mice of nuclear hormone receptor binding sites in the Igf2/H19 imprinting control region.
  Szabó PE, Han L, Hyo-Jung J, Mann JR
  Cytogenet Genome Res. 2006
  PubMed ID: 16575186
   
  
• The 3' portion of the mouse H19 Imprinting-Control Region is required for proper tissue-specific expression of the Igf2 gene.
  Hagège H, Nasser R, Weber M, Milligan L, Aptel N, Jacquet C, Drewell RA, Dandolo L, Surani MA, Cathala G, Forné T
  Cytogenet Genome Res. 2006
  PubMed ID: 16575185
   
  
• Insulin-like growth factor I and II expression and modulation in amoeboid microglial cells by lipopolysaccharide and retinoic acid.
  Kaur C, Sivakumar V, Dheen ST, Ling EA
  Neuroscience. 2006
  PubMed ID: 16448778
   
  
• A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys.
  Rodríguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, Miller GJ, Cooper CC, Cook DG, Whincup PH, Day IN
  Pharmacogenet Genomics. 2006
  PubMed ID: 16344718
   
  
• Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
  Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
  Genome Res. 2006
  PubMed ID: 16344560
   
  
• Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
  Rodríguez S, Gaunt TR, Dennison E, Chen XH, Syddall HE, Phillips DI, Cooper C, Day IN
  Eur J Hum Genet. 2006
  PubMed ID: 16251897
   
  
• Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
  Constância M, Angiolini E, Sandovici I, Smith P, Smith R, Kelsey G, Dean W, Ferguson-Smith A, Sibley CP, Reik W, Fowden A
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16365304
   
  
• Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk.
  Kaneda A, Feinberg AP
  Cancer Res. 2005
  PubMed ID: 16357124
   
  
• Association between the insulin-like growth factor 2 gene (IGF2) and scores on the Eating Attitudes Test in nonclinical subjects: a family-based study.
  Bachner-Melman R, Zohar AH, Nemanov L, Heresco-Levy U, Gritsenko I, Ebstein RP
  Am J Psychiatry. 2005
  PubMed ID: 16330588
   
  
• Pregnancy-associated plasma protein-A regulates myoblast proliferation and differentiation through an insulin-like growth factor-dependent mechanism.
  Kumar A, Mohan S, Newton J, Rehage M, Tran K, Baylink DJ, Qin X
  J Biol Chem. 2005
  PubMed ID: 16115888
   
  
• TGFalpha reactivates imprinted Igf2 in the parthenogenetic mice embryos and placenta.
  Rostam Zadehl J, Penkov LI, Klimov EA, Platonov ES, Sulimova GE
  Genetika. 2005
  PubMed ID: 16316011
   
  
• Control of fetal growth and neonatal survival by the RasGAP-associated endoribonuclease G3BP.
  Zekri L, Chebli K, Tourrière H, Nielsen FC, Hansen TV, Rami A, Tazi J
  Mol Cell Biol. 2005
  PubMed ID: 16166649
   
  
• The cooperative transforming effects of PAX3-FKHR and IGF-II on mouse myoblasts.
  Wang W, Slevin M, Kumar S, Kumar P
  Int J Oncol. 2005
  PubMed ID: 16142327
   
  
• Association between birth weight, body mass index and IGF2/ApaI polymorphism.
  Gomes MV, Soares MR, Pasqualim-Neto A, Marcondes CR, Lôbo RB, Ramos ES
  Growth Horm IGF Res. 2005
  PubMed ID: 16102992
   
  
• Resveratrol regulates insulin-like growth factor-II in breast cancer cells.
  Vyas S, Asmerom Y, De León DD
  Endocrinology. 2005
  PubMed ID: 16037384
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.
  Qiu Q, Basak A, Mbikay M, Tsang BK, Gruslin A
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16040806
   
  
• Type XIII collagen strongly affects bone formation in transgenic mice.
  Ylönen R, Kyrönlahti T, Sund M, Ilves M, Lehenkari P, Tuukkanen J, Pihlajaniemi T
  J Bone Miner Res. 2005
  PubMed ID: 16007336
   
  
• Glutathione S-transferase M1 gene but not insulin-like growth factor-2 gene or epidermal growth factor gene is associated with prostate cancer.
  Lai MT, Chen RH, Tsai FJ, Wan L, Chen WC
  Urol Oncol. 2005
  PubMed ID: 16018936
   
  
• Insulin-like growth factor II and binding proteins 1 and 3 from second trimester human amniotic fluid are associated with infant birth weight.
  Tisi DK, Liu XJ, Wykes LJ, Skinner CD, Koski KG
  J Nutr. 2005
  PubMed ID: 15987847
   
  
• Effects of IGF-II on promoting proliferation and regulating nitric oxide synthase gene expression in mouse osteoblast-like cell.
  Sun WL, Chen LL, Yan J, Yu ZS
  J Zhejiang Univ Sci B. 2005
  PubMed ID: 15973776
   
  
• Skeletal muscle mRNA for IGF-IEa, IGF-II, and IGF-I receptor is decreased in sedentary chronic hemodialysis patients.
  Wang H, Casaburi R, Taylor WE, Aboellail H, Storer TW, Kopple JD
  Kidney Int. 2005
  PubMed ID: 15954927
   
  
• Domain interactions of the mannose 6-phosphate/insulin-like growth factor II receptor.
  Kreiling JL, Byrd JC, MacDonald RG
  J Biol Chem. 2005
  PubMed ID: 15799974
   
  
• Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance.
  Carrick FE, Hinds MG, McNeil KA, Wallace JC, Forbes BE, Norton RS
  J Mol Endocrinol. 2005
  PubMed ID: 15956340
   
  
• Interleukin-5 potentiates the growth response of Caco-2 cells to IGF-II: a role in colonic carcinogenesis complicating ulcerative colitis?
  Makins R, Ballinger A
  Growth Horm IGF Res. 2005
  PubMed ID: 15935984
   
  
• CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.
  Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M
  J Biol Chem. 2005
  PubMed ID: 15769738
   
  
• Roles of insulin-like growth factor (IGF) binding proteins in regulating IGF actions.
  Duan C, Xu Q
  Gen Comp Endocrinol. 2005
  PubMed ID: 15862547
   
  
• Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells.
  Yi HK, Kim SY, Hwang PH, Kim CY, Yang DH, Oh Y, Lee DY
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15809062
   
  
• Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer.
  Kaur R, Nagpal JK, Das BR
  Tumour Biol. 2005
  PubMed ID: 15970649
   
  
• Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.
  Katz DJ, Beer MA, Levorse JM, Tilghman SM
  Mol Cell Biol. 2005
  PubMed ID: 15870260
   
  
• Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis.
  Spaczynski RZ, Tilly JL, Mansour A, Duleba AJ
  Mol Hum Reprod. 2005
  PubMed ID: 15833775
   
  
• Delayed and disturbed morphogenesis of the umbilical blood vessels in insulin-like growth factor-II deficient conceptuses (Igf2m+/p-).
  Ahmad AM, Burns J, Gardner R, Graham C
  Dev Dyn. 2005
  PubMed ID: 15765507
   
  
• Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.
  Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, de Boom Witzel S, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP
  Science. 2005
  PubMed ID: 15731405
   
  
• Hypoxic stress enhances osteoclast differentiation via increasing IGF2 production by non-osteoclastic cells.
  Fukuoka H, Aoyama M, Miyazawa K, Asai K, Goto S
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15707961
   
  
• Interaction of insulin-like growth factor II (IGF-II) with multiple plasma proteins: high affinity binding of plasminogen to IGF-II and IGF-binding protein-3.
  Oesterreicher S, Blum WF, Schmidt B, Braulke T, Kübler B
  J Biol Chem. 2005
  PubMed ID: 15642732
   
  
• Deregulation of DNA methyltransferases and loss of parental methylation at the insulin-like growth factor II (Igf2)/H19 loci in p53 knockout mice prior to tumor development.
  Park IY, Sohn BH, Choo JH, Joe CO, Seong JK, Lee YI, Chung JH
  J Cell Biochem. 2005
  PubMed ID: 15543560
   
  
• IGFs increase enamel formation by inducing expression of enamel mineralizing specific genes.
  Catón J, Bringas P, Zeichner-David M
  Arch Oral Biol. 2005
  PubMed ID: 15721138
   
  
• Overexpression of mature insulin-like growth factor (IGF)-II leads to growth arrest in Caco-2 human colon cancer cells.
  Kim EJ, Holthuizen PE, Kim J, Park JH
  Growth Horm IGF Res. 2005
  PubMed ID: 15701574
   
  
• Effects of insulin-like growth factors and insulin-like growth factor binding protein-2 on the in vitro proliferation of peripheral blood mononuclear cells.
  Hettmer S, Dannecker L, Foell J, Elmlinger MW, Dannecker GE
  Hum Immunol. 2005
  PubMed ID: 15694994
   
  
• Lsh controls silencing of the imprinted Cdkn1c gene.
  Fan T, Hagan JP, Kozlov SV, Stewart CL, Muegge K
  Development. 2005
  PubMed ID: 15647320
   
  
• Down-regulation of the IGF-2/H19 locus during normal and malignant hematopoiesis is independent of the imprinting pattern.
  Tessema M, Länger F, Bock O, Seltsam A, Metzig K, Hasemeier B, Kreipe H, Lehmann U
  Int J Oncol. 2005
  PubMed ID: 15645136
   
  
• Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study.
  Stessman J, Maaravi Y, Hammerman-Rozenberg R, Cohen A, Nemanov L, Gritsenko I, Gruberman N, Ebstein RP
  Mech Ageing Dev. 2005
  PubMed ID: 15621215
   
  
• [Insulin-like growth factor (IGF)-II in human hepatocarcinogenesis--a potential therapeutic target?]
  Nussbaum T, Vreden S, Farsad M, Schirmacher P, Breuhahn K
  Verh Dtsch Ges Pathol. 2005
  PubMed ID: 18035699
   
  
• Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.
  Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T
  DNA Res. 2005
  PubMed ID: 16303743
   
  
• Single-nucleotide polymorphisms and haplotype LD analysis of the 29-kb IGF2 region on chromosome 11p15.5 in the Korean population.
  Lee HJ, Kim KJ, Park MH, Kimm K, Park C, Oh B, Lee JY
  Hum Hered. 2005
  PubMed ID: 16166779
   
  
• Insulin-like growth factor signaling in fish.
  Wood AW, Duan C, Bern HA
  Int Rev Cytol. 2005
  PubMed ID: 15797461
   
  
• Abnormal thymic microenvironment in insulin-like growth factor-II transgenic mice.
  Savino W, Cotta-de-Almeida V, van Buul-Offers SC, Koster JG, Dardenne M
  Neuroimmunomodulation. 2005
  PubMed ID: 15785112
   
  
• Inactivation of imprinted genes induced by cellular stress and tumorigenesis.
  Pantoja C, de Los Ríos L, Matheu A, Antequera F, Serrano M
  Cancer Res. 2005
  PubMed ID: 15665276
   
  
• Identification of markers of the midface.
  Gong SG, Gong TW, Shum L
  J Dent Res. 2005
  PubMed ID: 15615879
   
  
• A loss of insulin-like growth factor-2 imprinting is modulated by CCCTC-binding factor down-regulation at senescence in human epithelial cells.
  Fu VX, Schwarze SR, Kenowski ML, Leblanc S, Svaren J, Jarrard DF
  J Biol Chem. 2004
  PubMed ID: 15471867
   
  
• IGF-II binding to insulin receptor isoform A induces a partially different gene expression profile from insulin binding.
  Pandini G, Conte E, Medico E, Sciacca L, Vigneri R, Belfiore A
  Ann N Y Acad Sci. 2004
  PubMed ID: 15650270
   
  
• Insulin-like growth factor-2 genotype, fat-free mass, and muscle performance across the adult life span.
  Schrager MA, Roth SM, Ferrell RE, Metter EJ, Russek-Cohen E, Lynch NA, Lindle RS, Hurley BF
  J Appl Physiol. 2004
  PubMed ID: 15298990
   
  
• Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells.
  Liao B, Patel M, Hu Y, Charles S, Herrick DJ, Brewer G
  J Biol Chem. 2004
  PubMed ID: 15355996
   
  
• Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.
  Hartnell A, Heinemann A, Conroy DM, Wait R, Sturm GJ, Caversaccio M, Jose PJ, Williams TJ
  J Immunol. 2004
  PubMed ID: 15528386
   
  
• Large-scale cDNA transfection screening for genes related to cancer development and progression.
  Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15498874
   
  
• FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo.
  Long L, Spear BT
  Mol Cell Biol. 2004
  PubMed ID: 15485926
   
  
• Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility.
  Hensen K, Braem C, Declercq J, Van Dyck F, Dewerchin M, Fiette L, Denef C, Van de Ven WJ
  Dev Growth Differ. 2004
  PubMed ID: 15606491
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10.
  Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL
  Development. 2004
  PubMed ID: 15459106
   
  
• Structural determinants for high-affinity binding of insulin-like growth factor II to insulin receptor (IR)-A, the exon 11 minus isoform of the IR.
  Denley A, Bonython ER, Booker GW, Cosgrove LJ, Forbes BE, Ward CW, Wallace JC
  Mol Endocrinol. 2004
  PubMed ID: 15205474
   
  
• Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells.
  Faridi JS, Mohan S, De León DD
  Growth Factors. 2004
  PubMed ID: 15518240
   
  
• Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
  Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
  Genome Res. 2004
  PubMed ID: 15342556
   
  
• Genomic analysis of mouse retinal development.
  Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
  PLoS Biol. 2004
  PubMed ID: 15226823
   
  
• Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.
  Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ
  Mol Endocrinol. 2004
  PubMed ID: 15192078
   
  
• An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissues.
  Charalambous M, Menheniott TR, Bennett WR, Kelly SM, Dell G, Dandolo L, Ward A
  Dev Biol. 2004
  PubMed ID: 15223349
   
  
• Genomic imprinting of IGF2 is maintained in infantile hemangioma despite its high level of expression.
  Yu Y, Wylie-Sears J, Boscolo E, Mulliken JB, Bischoff J
  Mol Med. 2004
  PubMed ID: 15706404
   
  
• Quantitative mass spectrometric immunoassay of insulin like growth factor 1.
  Nelson RW, Nedelkov D, Tubbs KA, Kiernan UA
  J Proteome Res. 2004
  PubMed ID: 15359740
   
  
• Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region.
  Lewis A, Mitsuya K, Constancia M, Reik W
  Mol Cell Biol. 2004
  PubMed ID: 15199123
   
  
• IGF-II is up-regulated and myofibres are hypertrophied in regenerating soleus of mice lacking FGF6.
  Armand AS, Lécolle S, Launay T, Pariset C, Fiore F, Della Gaspera B, Birnbaum D, Chanoine C, Charbonnier F
  Exp Cell Res. 2004
  PubMed ID: 15194422
   
  
• Insulin-like growth factor-II regulates the expression of vascular endothelial growth factor by the human keratinocyte cell line HaCaT.
  Kwon YW, Kwon KS, Moon HE, Park JA, Choi KS, Kim YS, Jang HS, Oh CK, Lee YM, Kwon YG, Lee YS, Kim KW
  J Invest Dermatol. 2004
  PubMed ID: 15191555
   
  
• Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size.
  Singer CF, Mogg M, Koestler W, Pacher M, Marton E, Kubista E, Schreiber M
  Clin Cancer Res. 2004
  PubMed ID: 15217931
   
  
• Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity.
  San Millán JL, Cortón M, Villuendas G, Sancho J, Peral B, Escobar-Morreale HF
  J Clin Endocrinol Metab. 2004
  PubMed ID: 15181035
   
  
• Role of CTCF binding sites in the Igf2/H19 imprinting control region.
  Szabó PE, Tang SH, Silva FJ, Tsark WM, Mann JR
  Mol Cell Biol. 2004
  PubMed ID: 15143173
   
  
• Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.
  Sibley CP, Coan PM, Ferguson-Smith AC, Dean W, Hughes J, Smith P, Reik W, Burton GJ, Fowden AL, Constância M
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 15150410
   
  
• Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells.
  Dressel R, Raja SM, Höning S, Seidler T, Froelich CJ, von Figura K, Günther E
  J Biol Chem. 2004
  PubMed ID: 14985351
   
  
• Insulin-like growth factors (IGF) and IGF-binding proteins bound to vitronectin enhance keratinocyte protein synthesis and migration.
  Hyde C, Hollier B, Anderson A, Harkin D, Upton Z
  J Invest Dermatol. 2004
  PubMed ID: 15140223
   
  
• Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice.
  Hansen TV, Hammer NA, Nielsen J, Madsen M, Dalbaeck C, Wewer UM, Christiansen J, Nielsen FC
  Mol Cell Biol. 2004
  PubMed ID: 15121863
   
  
• Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function.
  Cobb LJ, Salih DA, Gonzalez I, Tripathi G, Carter EJ, Lovett F, Holding C, Pell JM
  J Cell Sci. 2004
  PubMed ID: 15075235
   
  
• Mutation of a single CTCF target site within the H19 imprinting control region leads to loss of Igf2 imprinting and complex patterns of de novo methylation upon maternal inheritance.
  Pant V, Kurukuti S, Pugacheva E, Shamsuddin S, Mariano P, Renkawitz R, Klenova E, Lobanenkov V, Ohlsson R
  Mol Cell Biol. 2004
  PubMed ID: 15060168
   
  
• The human plasma proteome: a nonredundant list developed by combination of four separate sources.
  Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A
  Mol Cell Proteomics. 2004
  PubMed ID: 14718574
   
  
• Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells.
  Zhang CC, Lodish HF
  Blood. 2004
  PubMed ID: 14592820
   
  
• Loss of insulin-like growth factor-II imprinting and the presence of screen-detected colorectal adenomas in women.
  Woodson K, Flood A, Green L, Tangrea JA, Hanson J, Cash B, Schatzkin A, Schoenfeld P
  J Natl Cancer Inst. 2004
  PubMed ID: 14996863
   
  
• Hypomethylation of DNA and the insulin-like growth factor-II gene in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
  Tao L, Li Y, Kramer PM, Wang W, Pereira MA
  Toxicology. 2004
  PubMed ID: 15036762
   
  
• Combinatorial signaling pathways determine fibroblast proliferation and myofibroblast differentiation.
  Grotendorst GR, Rahmanie H, Duncan MR
  FASEB J. 2004
  PubMed ID: 15003992
   
  
• Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development.
  Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, Füchtbauer EM, Oxvig C, van Deursen J
  Development. 2004
  PubMed ID: 14973274
   
  
• Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma.
  Zatkova A, Rouillard JM, Hartmann W, Lamb BJ, Kuick R, Eckart M, von Schweinitz D, Koch A, Fonatsch C, Pietsch T, Hanash SM, Wimmer K
  Genes Chromosomes Cancer. 2004
  PubMed ID: 14695992
   
  
• An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.
  Murrell A, Heeson S, Cooper WN, Douglas E, Apostolidou S, Moore GE, Maher ER, Reik W
  Hum Mol Genet. 2004
  PubMed ID: 14645199
   
  
• The relationship between insulin-like growth factor-II gene Apa I polymorphism and rheumatoid arthritis.
  Huang CM, Tsai CH, Tsai JJ, Kung PT, Chen CL, Tsai FJ
  Scand J Rheumatol. 2004
  PubMed ID: 15163116
   
  
• Longitudinal data for intrauterine levels of fetal IGF-I and IGF-II.
  Gohlke BC, Fahnenstich H, Dame C, Albers N
  Horm Res. 2004
  PubMed ID: 14764950
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
  Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
  Visel A, Thaller C, Eichele G
  Nucleic Acids Res. 2004
  PubMed ID: 14681479
   
  
• Insulin-like growth factor-II regulates PTEN expression in the mammary gland.
  Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KL, Edwards DR, Khokha R
  J Biol Chem. 2003
  PubMed ID: 14517213
   
  
• Genomic imprinting controls matrix attachment regions in the Igf2 gene.
  Weber M, Hagège H, Murrell A, Brunel C, Reik W, Cathala G, Forné T
  Mol Cell Biol. 2003
  PubMed ID: 14645508
   
  
• Zinc partitions insulin-like growth factors (IGFs) from soluble IGF binding protein (IGFBP)-5 to the cell surface receptors of BC3H-1 muscle cells.
  McCusker RH, Novakofski J
  J Cell Physiol. 2003
  PubMed ID: 14566968
   
  
• Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
  Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14610273
   
  
• Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation.
  Hernandez L, Kozlov S, Piras G, Stewart CL
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14581617
   
  
• Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment.
  Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE
  Horm Metab Res. 2003
  PubMed ID: 14710345
   
  
• Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region.
  Bowman AB, Levorse JM, Ingram RS, Tilghman SM
  Mol Cell Biol. 2003
  PubMed ID: 14585991
   
  
• Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A.
  Pandini G, Medico E, Conte E, Sciacca L, Vigneri R, Belfiore A
  J Biol Chem. 2003
  PubMed ID: 12881524
   
  
• Autocrine growth factor signaling by insulin-like growth factor-II mediates MyoD-stimulated myocyte maturation.
  Wilson EM, Hsieh MM, Rotwein P
  J Biol Chem. 2003
  PubMed ID: 12941952
   
  
• Genetic and genetic expression analyses of clear cell sarcoma of the kidney.
  Schuster AE, Schneider DT, Fritsch MK, Grundy P, Perlman EJ
  Lab Invest. 2003
  PubMed ID: 13679437
   
  
• Interaction of insulin-like growth factor binding protein-3 with latent transforming growth factor-beta binding protein-1.
  Gui Y, Murphy LJ
  Mol Cell Biochem. 2003
  PubMed ID: 12962157
   
  
• The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver.
  Bouzin C, Clotman F, Renauld JC, Lemaigre FP, Rousseau GG
  J Immunol. 2003
  PubMed ID: 12874218
   
  
• Vascular endothelial growth factor gene polymorphism is associated with calcium oxalate stone disease.
  Chen WC, Chen HY, Wu HC, Wu MC, Hsu CD, Tsai FJ
  Urol Res. 2003
  PubMed ID: 12719950
   
  
• PTEN modulates insulin-like growth factor II (IGF-II)-mediated signaling; the protein phosphatase activity of PTEN downregulates IGF-II expression in hepatoma cells.
  Kang-Park S, Lee YI, Lee YI
  FEBS Lett. 2003
  PubMed ID: 12804776
   
  
• Low circulating IGF-II concentrations predict weight gain and obesity in humans.
  Sandhu MS, Gibson JM, Heald AH, Dunger DB, Wareham NJ
  Diabetes. 2003
  PubMed ID: 12765950
   
  
• Activation of insulin-like growth factor II signaling by mutant type p53: physiological implications for potentiation of IGF-II signaling by p53 mutant 249.
  Lee YI, Han YJ, Lee SY, Lee YI, Park SK, Park YJ, Moon HB, Shin JH, Lee JH
  Mol Cell Endocrinol. 2003
  PubMed ID: 12782403
   
  
• In vivo processed fragments of IGF binding protein-2 copurified with bioactive IGF-II.
  Ständker L, Kübler B, Obendorf M, Braulke T, Forssmann WG, Mark S
  Biochem Biophys Res Commun. 2003
  PubMed ID: 12727212
   
  
• A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus.
  Watanabe I, Tomita A, Shimizu M, Sugawara M, Yasumo H, Koishi R, Takahashi T, Miyoshi K, Nakamura K, Izumi T, Matsushita Y, Furukawa H, Haruyama H, Koga T
  Clin Pharmacol Ther. 2003
  PubMed ID: 12732844
   
  
• The insulin-like growth factor/insulin system in epithelial ovarian cancer.
  Kalli KR, Conover CA
  Front Biosci. 2003
  PubMed ID: 12700030
   
  
• Loss of imprinting of IGF2 sense and antisense transcripts in Wilms' tumor.
  Vu TH, Chuyen NV, Li T, Hoffman AR
  Cancer Res. 2003
  PubMed ID: 12702581
   
  
• Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle.
  Saito T, Akutsu S, Urushiyama T, Ishibashi K, Nakagawa Y, Shuler CF, Yamane A
  Zoolog Sci. 2003
  PubMed ID: 12719647
   
  
• Genome imprinting regulated by the mouse Polycomb group protein Eed.
  Mager J, Montgomery ND, de Villena FP, Magnuson T
  Nat Genet. 2003
  PubMed ID: 12627233
   
  
• Loss of IGF2 imprinting: a potential marker of colorectal cancer risk.
  Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, Wu Y, He X, Powe NR, Feinberg AP
  Science. 2003
  PubMed ID: 12637750
   
  
• Relaxation of imprinting of IGFII gene in juvenile nasopharyngeal angiofibromas.
  Coutinho-Camillo CM, Brentani MM, Butugan O, Torloni H, Nagai MA
  Diagn Mol Pathol. 2003
  PubMed ID: 12605037
   
  
• Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanisms.
  Mohan S, Richman C, Guo R, Amaar Y, Donahue LR, Wergedal J, Baylink DJ
  Endocrinology. 2003
  PubMed ID: 12586770
   
  
• Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin.
  Bennett WR, Crew TE, Slack JM, Ward A
  Development. 2003
  PubMed ID: 12571100
   
  
• Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.
  Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK
  Mol Endocrinol. 2003
  PubMed ID: 12554791
   
  
• Loss of Igf2 imprinting in monoclonal mouse hepatic tumor cells is not associated with abnormal methylation patterns for the H19, Igf2, and Kvlqt1 differentially methylated regions.
  Ishizaki T, Yoshie M, Yaginuma Y, Tanaka T, Ogawa K
  J Biol Chem. 2003
  PubMed ID: 12475990
   
  
• Imprint control element-mediated secondary methylation imprints at the Igf2/H19 locus.
  Srivastava M, Frolova E, Rottinghaus B, Boe SP, Grinberg A, Lee E, Love PE, Pfeifer K
  J Biol Chem. 2003
  PubMed ID: 12270940
   
  
• Detection of bound and free IGF-1 and IGF-2 in human plasma via biomolecular interaction analysis mass spectrometry.
  Nedelkov D, Nelson RW, Kiernan UA, Niederkofler EE, Tubbs KA
  FEBS Lett. 2003
  PubMed ID: 12586351
   
  
• [The expression and imprinting status of insulin-like growth factor 2 gene in colorectal cancer]
  Zhang FR, He XB, Yang YH, Xie W
  Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003
  PubMed ID: 12579496
   
  
• Immunohistochemical localization of insulin-like growth factor-II and its binding protein-6 in human epithelial cells of Malassez.
  Götz W, Lossdörfer S, Krüger U, Braumann B, Jäger A
  Eur J Oral Sci. 2003
  PubMed ID: 12558805
   
  
• Expression of IGF-II in early experimental hepatocellular carcinomas and its significance in early diagnosis.
  Wang Z, Ruan YB, Guan Y, Liu SH
  World J Gastroenterol. 2003
  PubMed ID: 12532445
   
  
• Polymorphism of the insulin gene is associated with increased prostate cancer risk.
  Ho GY, Melman A, Liu SM, Li M, Yu H, Negassa A, Burk RD, Hsing AW, Ghavamian R, Chua SC
  Br J Cancer. 2003
  PubMed ID: 12610512
   
  
• Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma.
  Tsai FJ, Lin HJ, Chen WC, Chen HY, Fan SS
  J Clin Lab Anal. 2003
  PubMed ID: 14614750
   
  
• Deficiency of mannose 6-phosphate receptors and lysosomal storage: a morphometric analysis of hepatocytes of neonatal mice.
  Schellens JP, Saftig P, von Figura K, Everts V
  Cell Biol Int. 2003
  PubMed ID: 14585283
   
  
• The role of insulin-like growth factor II and its receptor in mouse preimplantation development.
  Pantaleon M, Jericho H, Rabnott G, Kaye PL
  Reprod Fertil Dev. 2003
  PubMed ID: 12729502
   
  
• Relaxin causes proliferation of human amniotic epithelium by stimulation of insulin-like growth factor-II.
  Millar LK, Reiny R, Yamamoto SY, Okazaki K, Webster L, Bryant-Greenwood GD
  Am J Obstet Gynecol. 2003
  PubMed ID: 12548223
   
  
• Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease.
  Krassas GE, Pontikides N, Kaltsas T, Dumas A, Frystyk J, Chen JW, Flyvbjerg A
  J Clin Endocrinol Metab. 2003
  PubMed ID: 12519841
   
  
• The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.
  McBurney MW, Yang X, Jardine K, Hixon M, Boekelheide K, Webb JR, Lansdorp PM, Lemieux M
  Mol Cell Biol. 2003
  PubMed ID: 12482959
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH.
  Mahy NL, Perry PE, Bickmore WA
  J Cell Biol. 2002
  PubMed ID: 12473685
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• IGF-2 is a mediator of prolactin-induced morphogenesis in the breast.
  Brisken C, Ayyannan A, Nguyen C, Heineman A, Reinhardt F, Tan J, Dey SK, Dotto GP, Weinberg RA, Jan T
  Dev Cell. 2002
  PubMed ID: 12479812
   
  
• Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.
  Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M
  Development. 2002
  PubMed ID: 12421715
   
  
• IGF alters jejunal glucose transporter expression and serum glucose levels in immature rats.
  Lane RH, Dvorak B, MacLennan NK, Dvorakova K, Halpern MD, Pham TD, Philipps AF
  Am J Physiol Regul Integr Comp Physiol. 2002
  PubMed ID: 12388463
   
  
• Polymorphism of the IGF2 gene, birth weight and grip strength in adult men.
  Sayer AA, Syddall H, O'Dell SD, Chen XH, Briggs PJ, Briggs R, Day IN, Cooper C
  Age Ageing. 2002
  PubMed ID: 12446294
   
  
• Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1.
  Fitzpatrick GV, Soloway PD, Higgins MJ
  Nat Genet. 2002
  PubMed ID: 12410230
   
  
• Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.
  Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A
  J Biol Chem. 2002
  PubMed ID: 12138094
   
  
• Telomerase rescues the expression levels of keratinocyte growth factor and insulin-like growth factor-II in senescent human fibroblasts.
  Kanzaki Y, Onoue F, Ishikawa F, Ide T
  Exp Cell Res. 2002
  PubMed ID: 12243757
   
  
• [Morphological, cytogenetic and molecular biological characteristics of lung cancer in persons exposed for a long time to radionuclide radiation pollution in the Semipalatinsk region of Kazakhstan]
  Kogan EA, Sagindikova GS, Sekamova SM, Jack G
  Arkh Patol. 2002
  PubMed ID: 12575534
   
  
• Expression of insulin-like growth factors IGF-I and IGF-II, and their receptors during the growth and megakaryocytic differentiation of K562 cells.
  Aro AL, Savikko J, Pulkkinen V, von Willebrand E
  Leuk Res. 2002
  PubMed ID: 12127559
   
  
• A dyad oct-binding sequence functions as a maintenance sequence for the unmethylated state within the H19/Igf2-imprinted control region.
  Hori N, Nakano H, Takeuchi T, Kato H, Hamaguchi S, Oshimura M, Sato K
  J Biol Chem. 2002
  PubMed ID: 12029086
   
  
• Altered placental development and intrauterine growth restriction in IGF binding protein-1 transgenic mice.
  Crossey PA, Pillai CC, Miell JP
  J Clin Invest. 2002
  PubMed ID: 12163461
   
  
• Allele-specific expression of imprinted genes in mouse migratory primordial germ cells.
  Szabó PE, Hübner K, Schöler H, Mann JR
  Mech Dev. 2002
  PubMed ID: 12049782
   
  
• Placental-specific IGF-II is a major modulator of placental and fetal growth.
  Constância M, Hemberger M, Hughes J, Dean W, Ferguson-Smith A, Fundele R, Stewart F, Kelsey G, Fowden A, Sibley C, Reik W
  Nature. 2002
  PubMed ID: 12087403
   
  
• Genomic imprinting: piece of cake.
  Tycko B, Efstratiadis A
  Nature. 2002
  PubMed ID: 12087392
   
  
• Placental overgrowth in mice lacking the imprinted gene Ipl.
  Frank D, Fortino W, Clark L, Musalo R, Wang W, Saxena A, Li CM, Reik W, Ludwig T, Tycko B
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12032310
   
  
• Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis.
  Ritter MR, Dorrell MI, Edmonds J, Friedlander SF, Friedlander M
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12032304
   
  
• Complementary expression of IGF-II and IGFBP-5 during anterior pituitary development.
  Holley SJ, Hall SB, Mellon PL
  Dev Biol. 2002
  PubMed ID: 11944940
   
  
• IGF2 genotype and obesity in men and women across the adult age span.
  Roth SM, Schrager MA, Metter EJ, Riechman SE, Fleg JL, Hurley BF, Ferrell RE
  Int J Obes Relat Metab Disord. 2002
  PubMed ID: 12075589
   
  
• The regional expression of insulin-like growth factor II (IGF-II) and insulin-like growth factor binding protein-1 (IGFBP-1) in the placentae of women with pre-eclampsia.
  Gratton RJ, Asano H, Han VK
  Placenta. 2002
  PubMed ID: 11969341
   
  
• Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.
  Hofmann WK, Takeuchi S, Frantzen MA, Hoelzer D, Koeffler HP
  Exp Hematol. 2002
  PubMed ID: 11937266
   
  
• Disruption of mesodermal enhancers for Igf2 in the minute mutant.
  Davies K, Bowden L, Smith P, Dean W, Hill D, Furuumi H, Sasaki H, Cattanach B, Reik W
  Development. 2002
  PubMed ID: 11923202
   
  
• Human insulin-like growth factor II leader 2 mediates internal initiation of translation.
  Pedersen SK, Christiansen J, Hansen TO, Larsen MR, Nielsen FC
  Biochem J. 2002
  PubMed ID: 11903044
   
  
• Mouse parthenogenetic embryos with monoallelic H19 expression can develop to day 17.5 of gestation.
  Kono T, Sotomaru Y, Katsuzawa Y, Dandolo L
  Dev Biol. 2002
  PubMed ID: 11884038
   
  
• Expression of IGF-II, IGFBP-2, -5, and -6 in meningiomas with different brain invasiveness.
  Nordqvist AC, Mathiesen T
  J Neurooncol. 2002
  PubMed ID: 12125963
   
  
• Expression of insulin-like growth factor (IGF), IGF receptor, and IGF-binding protein messenger ribonucleic acids in luteinized granulosa cells from different size follicles after controlled ovarian hyperstimulation.
  Chang SY, Tsai MY, Huang FJ, Kung FT
  J Assist Reprod Genet. 2002
  PubMed ID: 12005306
   
  
• Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors.
  Gao ZH, Suppola S, Liu J, Heikkilä P, Jänne J, Voutilainen R
  J Clin Endocrinol Metab. 2002
  PubMed ID: 11889182
   
  
• Novel conserved elements upstream of the H19 gene are transcribed and act as mesodermal enhancers.
  Drewell RA, Arney KL, Arima T, Barton SC, Brenton JD, Surani MA
  Development. 2002
  PubMed ID: 11874916
   
  
• Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1.
  van der Velden AW, van Nierop K, Voorma HO, Thomas AA
  Int J Biochem Cell Biol. 2002
  PubMed ID: 11849996
   
  
• Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling.
  Chiao E, Fisher P, Crisponi L, Deiana M, Dragatsis I, Schlessinger D, Pilia G, Efstratiadis A
  Dev Biol. 2002
  PubMed ID: 11846487
   
  
• Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model.
  Zaina S, Pettersson L, Ahrén B, Brånén L, Hassan AB, Lindholm M, Mattsson R, Thyberg J, Nilsson J
  J Biol Chem. 2002
  PubMed ID: 11726660
   
  
• Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland.
  González-Parra S, Rosato RR, Chowen JA, Argente J, Groffen C, Dits N, Drop SL
  Horm Res. 2002
  PubMed ID: 12006713
   
  
• Insulin-like growth factors and insulin-like growth factor binding proteins in adult patients with severe liver disease before and after orthotopic liver transplantation.
  Weber MM, Auernhammer CJ, Lee PD, Engelhardt D, Zachoval R
  Horm Res. 2002
  PubMed ID: 12006706
   
  
• Dnmt3L and the establishment of maternal genomic imprints.
  Bourc'his D, Xu GL, Lin CS, Bollman B, Bestor TH
  Science. 2001
  PubMed ID: 11719692
   
  
• Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3.
  Storch S, Kübler B, Höning S, Ackmann M, Zapf J, Blum W, Braulke T
  FEBS Lett. 2001
  PubMed ID: 11749962
   
  
• Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes.
  Ukkola O, Sun G, Bouchard C
  Diabetologia. 2001
  PubMed ID: 11793026
   
  
• An intragenic methylated region in the imprinted Igf2 gene augments transcription.
  Murrell A, Heeson S, Bowden L, Constância M, Dean W, Kelsey G, Reik W
  EMBO Rep. 2001
  PubMed ID: 11743023
   
  
• Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.
  Paulsen M, Takada S, Youngson NA, Benchaib M, Charlier C, Segers K, Georges M, Ferguson-Smith AC
  Genome Res. 2001
  PubMed ID: 11731499
   
  
• Regulatory mechanisms at the mouse Igf2/H19 locus.
  Kaffer CR, Grinberg A, Pfeifer K
  Mol Cell Biol. 2001
  PubMed ID: 11689707
   
  
• Normal size of the lumen of the aorta in dwarf mice lacking IGF-II.
  Zaina S, Pettersson L
  Growth Horm IGF Res. 2001
  PubMed ID: 11735248
   
  
• Microarray expression profiling of tissues from mice with uniparental duplications of chromosomes 7 and 11 to identify imprinted genes.
  Choi JD, Underkoffler LA, Collins JN, Marchegiani SM, Terry NA, Beechey CV, Oakey RJ
  Mamm Genome. 2001
  PubMed ID: 11668390
   
  
• Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.
  Buckway CK, Wilson EM, Ahlsén M, Bang P, Oh Y, Rosenfeld RG
  J Clin Endocrinol Metab. 2001
  PubMed ID: 11600567
   
  
• Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation.
  Burns JL, Hassan AB
  Development. 2001
  PubMed ID: 11585807
   
  
• Imprinting defects in mouse embryos: stochastic errors or polymorphic phenotype?
  Croteau S, Polychronakos C, Naumova AK
  Genesis. 2001
  PubMed ID: 11668673
   
  
• Kinetics and regulation of site-specific endonucleolytic cleavage of human IGF-II mRNAs.
  van Dijk EL, Sussenbach JS, Holthuizen PE
  Nucleic Acids Res. 2001
  PubMed ID: 11522816
   
  
• Monotreme IGF2 expression and ancestral origin of genomic imprinting.
  Killian JK, Nolan CM, Stewart N, Munday BL, Andersen NA, Nicol S, Jirtle RL
  J Exp Zool. 2001
  PubMed ID: 11479919
   
  
• Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
  Kalinichenko VV, Lim L, Stolz DB, Shin B, Rausa FM, Clark J, Whitsett JA, Watkins SC, Costa RH
  Dev Biol. 2001
  PubMed ID: 11437453
   
  
• Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males.
  Gaunt TR, Cooper JA, Miller GJ, Day IN, O'Dell SD
  Hum Mol Genet. 2001
  PubMed ID: 11448941
   
  
• Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity.
  Jones BK, Levorse J, Tilghman SM
  Hum Mol Genet. 2001
  PubMed ID: 11285246
   
  
• Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene.
  Howell CY, Bestor TH, Ding F, Latham KE, Mertineit C, Trasler JM, Chaillet JR
  Cell. 2001
  PubMed ID: 11290321
   
  
• Allele-specific detection of nascent transcripts by fluorescence in situ hybridization reveals temporal and culture-induced changes in Igf2 imprinting during pre-implantation mouse development.
  Ohno M, Aoki N, Sasaki H
  Genes Cells. 2001
  PubMed ID: 11260268
   
  
• Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting.
  Weber M, Milligan L, Delalbre A, Antoine E, Brunel C, Cathala G, Forné T
  Mech Dev. 2001
  PubMed ID: 11231066
   
  
• A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens.
  Thut CJ, Rountree RB, Hwa M, Kingsley DM
  Dev Biol. 2001
  PubMed ID: 11180952
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• Contribution of residues A54 and L55 of the human insulin-like growth factor-II (IGF-II) A domain to Type 2 IGF receptor binding specificity.
  Forbe BE, McNeil KA, Scott CD, Surinya KH, Cosgrove LJ, Wallace JC
  Growth Factors. 2001
  PubMed ID: 11811790
   
  
• Regulation of the Akt/Glycogen synthase kinase-3 axis by insulin-like growth factor-II via activation of the human insulin receptor isoform-A.
  Scalia P, Heart E, Comai L, Vigneri R, Sung CK
  J Cell Biochem. 2001
  PubMed ID: 11500939
   
  
• The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis.
  Vernucci M, Cerrato F, Besnard N, Casola S, Pedone PV, Bruni CB, Riccio A
  Oncogene. 2000
  PubMed ID: 11175353
   
  
• Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3.
  Kobayashi S, Wagatsuma H, Ono R, Ichikawa H, Yamazaki M, Tashiro H, Aisaka K, Miyoshi N, Kohda T, Ogura A, Ohki M, Kaneko-Ishino T, Ishino F
  Genes Cells. 2000
  PubMed ID: 11168589
   
  
• IGF-II ameliorates the dystrophic phenotype and coordinately down-regulates programmed cell death.
  Smith J, Goldsmith C, Ward A, LeDieu R
  Cell Death Differ. 2000
  PubMed ID: 11139285
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.
  Onyango P, Miller W, Lehoczky J, Leung CT, Birren B, Wheelan S, Dewar K, Feinberg AP
  Genome Res. 2000
  PubMed ID: 11076855
   
  
• Sequence and functional comparison in the Beckwith-Wiedemann region: implications for a novel imprinting centre and extended imprinting.
  Engemann S, Strödicke M, Paulsen M, Franck O, Reinhardt R, Lane N, Reik W, Walter J
  Hum Mol Genet. 2000
  PubMed ID: 11063728
   
  
• Imprinting of insulin-like growth factor 2 is modulated during hematopoiesis.
  Morison IM, Eccles MR, Reeve AE
  Blood. 2000
  PubMed ID: 11049980
   
  
• Large-scale screen for genes involved in gonad development.
  Wertz K, Herrmann BG
  Mech Dev. 2000
  PubMed ID: 11044607
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.
  Constância M, Dean W, Lopes S, Moore T, Kelsey G, Reik W
  Nat Genet. 2000
  PubMed ID: 11017078
   
  
• Two imprinted gene mutations: three phenotypes.
  Cattanach BM, Peters J, Ball S, Rasberry C
  Hum Mol Genet. 2000
  PubMed ID: 11001929
   
  
• Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.
  Hahn H, Wojnowski L, Specht K, Kappler R, Calzada-Wack J, Potter D, Zimmer A, Müller U, Samson E, Quintanilla-Martinez L, Zimmer A
  J Biol Chem. 2000
  PubMed ID: 10884376
   
  
• Selective alterations in organ sizes in mice with a targeted disruption of the insulin-like growth factor binding protein-2 gene.
  Wood TL, Rogler LE, Czick ME, Schuller AG, Pintar JE
  Mol Endocrinol. 2000
  PubMed ID: 10976924
   
  
• Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
  Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10922068
   
  
• A transcriptional insulator at the imprinted H19/Igf2 locus.
  Kaffer CR, Srivastava M, Park KY, Ives E, Hsieh S, Batlle J, Grinberg A, Huang SP, Pfeifer K
  Genes Dev. 2000
  PubMed ID: 10921905
   
  
• Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch.
  Drewell RA, Brenton JD, Ainscough JF, Barton SC, Hilton KJ, Arney KL, Dandolo L, Surani MA
  Development. 2000
  PubMed ID: 10903168
   
  
• Distinct RNA structural domains cooperate to maintain a specific cleavage site in the 3'-UTR of IGF-II mRNAs.
  van Dijk EL, Sussenbach JS, Holthuizen PE
  J Mol Biol. 2000
  PubMed ID: 10884343
   
  
• Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome.
  Grandjean V, Smith J, Schofield PN, Ferguson-Smith AC
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10779549
   
  
• Influence of FGF4 on digit morphogenesis during limb development in the mouse.
  Ngo-Muller V, Muneoka K
  Dev Biol. 2000
  PubMed ID: 10694418
   
  
• Expression and imprinting status of human PEG8/IGF2AS, a paternally expressed antisense transcript from the IGF2 locus, in Wilms' tumors.
  Okutsu T, Kuroiwa Y, Kagitani F, Kai M, Aisaka K, Tsutsumi O, Kaneko Y, Yokomori K, Surani MA, Kohda T, Kaneko-Ishino T, Ishino F
  J Biochem. 2000
  PubMed ID: 10731720
   
  
• Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice.
  Hassan AB, Howell JA
  Cancer Res. 2000
  PubMed ID: 10706126
   
  
• Collapsin response mediator protein-3/unc-33-like protein-4 gene: organization, chromosomal mapping and expression in the developing mouse brain.
  Quach TT, Mosinger B, Ricard D, Copeland NG, Gilbert DJ, Jenkins NA, Stankoff B, Honnorat J, Belin MF, Kolattukudy P
  Gene. 2000
  PubMed ID: 10721710
   
  
• Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7.
  Kato R, Shirohzu H, Yokomine T, Mizuno S, Mukai T, Sasaki H
  DNA Res. 1999
  PubMed ID: 10691133
   
  
• Insulin-like growth factor binding protein 2 is a growth inhibitory protein conserved in zebrafish.
  Duan C, Ding J, Li Q, Tsai W, Pozios K
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 10611375
   
  
• Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
  Caspary T, Cleary MA, Perlman EJ, Zhang P, Elledge SJ, Tilghman SM
  Genes Dev. 1999
  PubMed ID: 10601037
   
  
• Placental anionic and cationic amino acid transporter expression in growth hormone overexpressing and null IGF-II or null IGF-I receptor mice.
  Matthews JC, Beveridge MJ, Dialynas E, Bartke A, Kilberg MS, Novak DA
  Placenta. 1999
  PubMed ID: 10527818
   
  
• Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations.
  Jaskoll T, Melnick M
  Anat Rec. 1999
  PubMed ID: 10521784
   
  
• Enhancer competition between H19 and Igf2 does not mediate their imprinting.
  Schmidt JV, Levorse JM, Tilghman SM
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 10449763
   
  
• Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases.
  Gibson TL, Cohen P
  Growth Horm IGF Res. 1999
  PubMed ID: 10512690
   
  
• Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins.
  Wong MS, Fong CC, Yang M
  Biochim Biophys Acta. 1999
  PubMed ID: 10407151
   
  
• mRNA and protein localization of the IGF system during mouse embryonic development in areas with apoptosis.
  Kleffens M, Groffen C, Neck JW, Vermeij-Keers C, Drop SL
  Growth Horm IGF Res. 1999
  PubMed ID: 10502456
   
  
• Identification of vitronectin as a novel insulin-like growth factor-II binding protein.
  Upton Z, Webb H, Hale K, Yandell CA, McMurtry JP, Francis GL, Ballard FJ
  Endocrinology. 1999
  PubMed ID: 10342887
   
  
• Characterization of the insulin-like growth factor axis in the human thymus.
  Kecha O, Martens H, Franchimont N, Achour I, Hazée-Hagelstein MT, Charlet-Renard C, Geenen V, Winkler R
  J Neuroendocrinol. 1999
  PubMed ID: 10336724
   
  
• Alternative mechanisms for trafficking of lysosomal enzymes in mannose 6-phosphate receptor-deficient mice are cell type-specific.
  Dittmer F, Ulbrich EJ, Hafner A, Schmahl W, Meister T, Pohlmann R, von Figura K
  J Cell Sci. 1999
  PubMed ID: 10212152
   
  
• Developmental potential of mouse primordial germ cells.
  Kato Y, Rideout WM, Hilton K, Barton SC, Tsunoda Y, Surani MA
  Development. 1999
  PubMed ID: 10101117
   
  
• Genomic imprinting and cancer.
  Jirtle RL
  Exp Cell Res. 1999
  PubMed ID: 10094809
   
  
• Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP Superfamily.
  Burren CP, Wilson EM, Hwa V, Oh Y, Rosenfeld RG
  J Clin Endocrinol Metab. 1999
  PubMed ID: 10084601
   
  
• The imprinted domain in mouse distal Chromosome 7: reagents for mutagenesis and sequencing.
  Day CD, Smilinich NJ, Fitzpatrick GV, deJong PJ, Shows TB, Higgins MJ
  Mamm Genome. 1999
  PubMed ID: 9922400
   
  
• The role of insulin-like growth factors in small intestinal cell growth and development.
  MacDonald RS
  Horm Metab Res. 1999
  PubMed ID: 10226789
   
  
• The sins of the fathers and mothers: genomic imprinting in mammalian development.
  Tilghman SM
  Cell. 1999
  PubMed ID: 9988214
   
  
• Cytosine methylation and mammalian development.
  Walsh CP, Bestor TH
  Genes Dev. 1999
  PubMed ID: 9887097
   
  
• Insulin-like growth factor-2 regulation of conceptus composition: effects of the trophectoderm and inner cell mass genotypes in the mouse.
  Gardner RL, Squire S, Zaina S, Hills S, Graham CF
  Biol Reprod. 1999
  PubMed ID: 9858505
   
  
• Identification of thymus specific and developmentally regulated genes by an improved version of the mRNA differential display technique.
  Pascolo S, Tsoukatou D, Mamalaki C
  Dev Immunol. 1999
  PubMed ID: 10636473
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Gpc3 expression correlates with the phenotype of the Simpson-Golabi-Behmel syndrome.
  Pellegrini M, Pilia G, Pantano S, Lucchini F, Uda M, Fumi M, Cao A, Schlessinger D, Forabosco A
  Dev Dyn. 1998
  PubMed ID: 9853964
   
  
• Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.
  Thorvaldsen JL, Duran KL, Bartolomei MS
  Genes Dev. 1998
  PubMed ID: 9851976
   
  
• Growth and the distal tip of mouse chromosome 7.
  Graham CF, Lund G, Zaina S
  Genet Res. 1998
  PubMed ID: 10036982
   
  
• Mechanism of imprinting on mouse distal chromosome 7.
  Ainscough JF, John RM, Surani MA
  Genet Res. 1998
  PubMed ID: 10036981
   
  
• I-cell disease-like phenotype in mice deficient in mannose 6-phosphate receptors.
  Dittmer F, Hafner A, Ulbrich EJ, Moritz JD, Schmidt P, Schmahl W, Pohlmann R, Figura KV
  Transgenic Res. 1998
  PubMed ID: 10341453
   
  
• Transcriptional regulation and biological significance of the insulin like growth factor II gene.
  Engström W, Shokrai A, Otte K, Granérus M, Gessbo A, Bierke P, Madej A, Sjölund M, Ward A
  Cell Prolif. 1998
  PubMed ID: 9925986
   
  
• Structure-function analysis of the human insulin-like growth factor binding protein-4.
  Qin X, Strong DD, Baylink DJ, Mohan S
  J Biol Chem. 1998
  PubMed ID: 9722589
   
  
• Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology.
  Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, LeRoith D
  Comp Biochem Physiol B Biochem Mol Biol. 1998
  PubMed ID: 9972281
   
  
• H19 and Igf2 are expressed and differentially imprinted in neuroectoderm-derived cells in the mouse brain.
  Hemberger M, Redies C, Krause R, Oswald J, Walter J, Fundele RH
  Dev Genes Evol. 1998
  PubMed ID: 9732553
   
  
• Igf2 imprinting does not require its own DNA methylation or H19 RNA.
  Jones BK, Levorse JM, Tilghman SM
  Genes Dev. 1998
  PubMed ID: 9679064
   
  
• Insulin-like growth factor II (IGF-II).
  O'Dell SD, Day IN
  Int J Biochem Cell Biol. 1998
  PubMed ID: 9722981
   
  
• Genome scan and congenic strains for blood pressure QTL using Dahl salt-sensitive rats.
  Garrett MR, Dene H, Walder R, Zhang QY, Cicila GT, Assadnia S, Deng AY, Rapp JP
  Genome Res. 1998
  PubMed ID: 9685318
   
  
• Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5.
  Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies KE, Hu RJ, Feinberg AP, Maher ER, Reik W, Walter J
  Hum Mol Genet. 1998
  PubMed ID: 9618174
   
  
• The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA.
  Schuster-Gossler K, Bilinski P, Sado T, Ferguson-Smith A, Gossler A
  Dev Dyn. 1998
  PubMed ID: 9626496
   
  
• Multiple mechanisms regulate imprinting of the mouse distal chromosome 7 gene cluster.
  Caspary T, Cleary MA, Baker CC, Guan XJ, Tilghman SM
  Mol Cell Biol. 1998
  PubMed ID: 9584186
   
  
• Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes.
  Dean W, Bowden L, Aitchison A, Klose J, Moore T, Meneses JJ, Reik W, Feil R
  Development. 1998
  PubMed ID: 9584126
   
  
• Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome.
  Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A
  Nat Med. 1998
  PubMed ID: 9585239
   
  
• Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene.
  Hatano N, Eversole-Cire P, Ferguson-Smith AC, Jones PA, Surani MA, Sasaki H
  J Biochem. 1998
  PubMed ID: 9562635
   
  
• Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis.
  Obata Y, Kaneko-Ishino T, Koide T, Takai Y, Ueda T, Domeki I, Shiroishi T, Ishino F, Kono T
  Development. 1998
  PubMed ID: 9502736
   
  
• mRNA expression patterns of the IGF system during mouse limb bud development, determined by whole mount in situ hybridization.
  van Kleffens M, Groffen C, Rosato RR, van den Eijnde SM, van Neck JW, Lindenbergh-Kortleve DJ, Zwarthoff EC, Drop SL
  Mol Cell Endocrinol. 1998
  PubMed ID: 9685224
   
  
• Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
  Twigg SM, Baxter RC
  J Biol Chem. 1998
  PubMed ID: 9497324
   
  
• Identification of elf1, a beta-spectrin, in early mouse liver development.
  Mishra L, Cai T, Levine A, Weng D, Mezey E, Mishra B, Gearhart J
  Int J Dev Biol. 1998
  PubMed ID: 9551868
   
  
• Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice.
  Sohar I, Sleat D, Gong Liu C, Ludwig T, Lobel P
  Biochem J. 1998
  PubMed ID: 9480908
   
  
• Imprinting of mouse Kvlqt1 is developmentally regulated.
  Gould TD, Pfeifer K
  Hum Mol Genet. 1998
  PubMed ID: 9467008
   
  
• Location of enhancers is essential for the imprinting of H19 and Igf2 genes.
  Webber AL, Ingram RS, Levorse JM, Tilghman SM
  Nature. 1998
  PubMed ID: 9490417
   
  
• Structural determinants of ligand and cell surface binding of insulin-like growth factor-binding protein-3.
  Firth SM, Ganeshprasad U, Baxter RC
  J Biol Chem. 1998
  PubMed ID: 9446566
   
  
• Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis.
  Melnick M, Chen H, Buckley S, Warburton D, Jaskoll T
  Dev Dyn. 1998
  PubMed ID: 9438420
   
  
• The mouse H19 locus mediates a transition between imprinted and non-imprinted DNA replication patterns.
  Greally JM, Starr DJ, Hwang S, Song L, Jaarola M, Zemel S
  Hum Mol Genet. 1998
  PubMed ID: 9384608
   
  
• Induction of amelogenin and ameloblastin by insulin and insulin-like growth factors (IGF-I and IGF-II) during embryonic mouse tooth development in vitro.
  Takahashi K, Yamane A, Bringas P, Caton J, Slavkin HC, Zeichner-David M
  Connect Tissue Res. 1998
  PubMed ID: 11063034
   
  
• Expression and imprinting of the insulin-like growth factor II gene in neonatal mouse cerebellum.
  Hetts SW, Rosen KM, Dikkes P, Villa-Komaroff L, Mozell RL
  J Neurosci Res. 1997
  PubMed ID: 9452010
   
  
• Roles of the imprinted gene Igf2 and paternal duplication of distal chromosome 7 in the perinatal abnormalities of androgenetic mouse chimeras.
  McLaughlin KJ, Kochanowski H, Solter D, Schwarzkopf G, Szabó PE, Mann JR
  Development. 1997
  PubMed ID: 9428426
   
  
• Mouse mutant embryos overexpressing IGF-II exhibit phenotypic features of the Beckwith-Wiedemann and Simpson-Golabi-Behmel syndromes.
  Eggenschwiler J, Ludwig T, Fisher P, Leighton PA, Tilghman SM, Efstratiadis A
  Genes Dev. 1997
  PubMed ID: 9389646
   
  
• Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2.
  Moore T, Constancia M, Zubair M, Bailleul B, Feil R, Sasaki H, Reik W
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9356480
   
  
• Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome.
  Sun FL, Dean WL, Kelsey G, Allen ND, Reik W
  Nature. 1997
  PubMed ID: 9349812
   
  
• Genetic isolation of a chromosome 1 region affecting blood pressure in the spontaneously hypertensive rat.
  St Lezin E, Liu W, Wang JM, Wang N, Kren V, Krenova D, Musilova A, Zdobinska M, Zidek V, Lau D, Pravenec M
  Hypertension. 1997
  PubMed ID: 9336384
   
  
• Gene expression of the insulin-like growth factor system during mouse kidney development.
  Lindenbergh-Kortleve DJ, Rosato RR, van Neck JW, Nauta J, van Kleffens M, Groffen C, Zwarthoff EC, Drop SL
  Mol Cell Endocrinol. 1997
  PubMed ID: 9324049
   
  
• Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern.
  Shemer R, Birger Y, Riggs AD, Razin A
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9294199
   
  
• Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans.
  Forné T, Oswald J, Dean W, Saam JR, Bailleul B, Dandolo L, Tilghman SM, Walter J, Reik W
  Proc Natl Acad Sci U S A. 1997
  PubMed ID: 9294195
   
  
• Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.
  Louvi A, Accili D, Efstratiadis A
  Dev Biol. 1997
  PubMed ID: 9281335
   
  
• Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome.
  Reik W, Maher ER
  Trends Genet. 1997
  PubMed ID: 9260520
   
  
• A candidate model for Angelman syndrome in the mouse.
  Cattanach BM, Barr JA, Beechey CV, Martin J, Noebels J, Jones J
  Mamm Genome. 1997
  PubMed ID: 9195990
   
  
• cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T.
  Koch A, Juan TS, Jenkins NA, Gilbert DJ, Copeland NG, McNiece IK, Fletcher FA
  Mamm Genome. 1997
  PubMed ID: 9107680
   
  
• Promoter-dependent tissue-specific expressive nature of imprinting gene, insulin-like growth factor II, in human tissues.
  Wu HK, Squire JA, Song Q, Weksberg R
  Biochem Biophys Res Commun. 1997
  PubMed ID: 9144427
   
  
• Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology.
  Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH
  Biochem Mol Med. 1997
  PubMed ID: 9169087
   
  
• The mouse chromosome 7 distal imprinting domain maps to G-bands F4/F5.
  Beechey CV, Ball ST, Townsend KM, Jones J
  Mamm Genome. 1997
  PubMed ID: 9096101
   
  
• Matrix-attachment regions in the mouse chromosome 7F imprinted domain.
  Greally JM, Guinness ME, McGrath J, Zemel S
  Mamm Genome. 1997
  PubMed ID: 9337391
   
  
• Expression of H19 does not influence the timing of replication of the Igf2/H19 imprinted region.
  Windham CQ, Jones PA
  Dev Genet. 1997
  PubMed ID: 9094209
   
  
• Imprinting mutation in the Beckwith-Wiedemann syndrome leads to biallelic IGF2 expression through an H19-independent pathway.
  Brown KW, Villar AJ, Bickmore W, Clayton-Smith J, Catchpoole D, Maher ER, Reik W
  Hum Mol Genet. 1996
  PubMed ID: 8968759
   
  
• Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.
  Oh Y, Nagalla SR, Yamanaka Y, Kim HS, Wilson E, Rosenfeld RG
  J Biol Chem. 1996
  PubMed ID: 8939990
   
  
• Nucleotide sequence of a 28-kb mouse genomic region comprising the imprinted Igf2 gene.
  Sasaki H, Shimozaki K, Zubair M, Aoki N, Ohta K, Hatano N, Moore T, Feil R, Constancia M, Reik W, Rotwein P
  DNA Res. 1996
  PubMed ID: 9039503
   
  
• Normalization and subtraction: two approaches to facilitate gene discovery.
  Bonaldo MF, Lennon G, Soares MB
  Genome Res. 1996
  PubMed ID: 8889548
   
  
• Genetic maps of polymorphic DNA loci on rat chromosome 1.
  Ding YP, Remmers EF, Du Y, Longman RE, Goldmuntz EA, Zha H, Kotake S, Cannon GW, Griffiths MM, Wilder RL
  Genomics. 1996
  PubMed ID: 8812459
   
  
• Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography.
  Bach LA, Rechler MM
  Biochim Biophys Acta. 1996
  PubMed ID: 8781553
   
  
• Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds.
  Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A
  Dev Biol. 1996
  PubMed ID: 8806828
   
  
• Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation.
  Hu JF, Vu TH, Hoffman AR
  J Biol Chem. 1996
  PubMed ID: 8663390
   
  
• The human/mouse imprinted genes IGF2, H19, SNRPN and ZNF127 map to two conserved autosomal clusters in a marsupial.
  Toder R, Wilcox SA, Smithwick M, Graves JA
  Chromosome Res. 1996
  PubMed ID: 8817070
   
  
• Expression of H19 and Igf2 genes in uniparental mouse ES cells during in vitro and in vivo differentiation.
  McKarney LA, Overall ML, Dziadek M
  Differentiation. 1996
  PubMed ID: 8641548
   
  
• Insulin-like growth factor II affects the appearance and glycogen content of glycogen cells in the murine placenta.
  Lopez MF, Dikkes P, Zurakowski D, Villa-Komaroff L
  Endocrinology. 1996
  PubMed ID: 8612553
   
  
• Autonomous differentiation in the mouse myogenic cell line, C2, involves a mutual positive control between insulin-like growth factor II and MyoD, operating as early as at the myoblast stage.
  Montarras D, Aurade F, Johnson T, IIan J, Gros F, Pinset C
  J Cell Sci. 1996
  PubMed ID: 8907701
   
  
• Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome.
  Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D
  Nat Genet. 1996
  PubMed ID: 8589713
   
  
• Expression of insulin-like growth factor II (IGF)-II) and H19 in murine teratocarcinomas derived from embryonic stem (ES) cells.
  Blythe NL, Senior PV, Beck F
  J Anat. 1996
  PubMed ID: 8655417
   
  
• Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1.
  Gu L, Dene H, Deng AY, Hoebee B, Bihoreau MT, James M, Rapp JP
  J Clin Invest. 1996
  PubMed ID: 8609235
   
  
• Defective chorioallantoic fusion in mid-gestation lethality of parthenogenone<-->tetraploid chimeras.
  Spindle A, Sturm KS, Flannery M, Meneses JJ, Wu K, Pedersen RA
  Dev Biol. 1996
  PubMed ID: 8606004
   
  
• Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast.
  McLaughlin KJ, Szabó P, Haegel H, Mann JR
  Development. 1996
  PubMed ID: 8565838
   
  
• Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1.
  Ward A, Pooler JA, Miyagawa K, Duarte A, Hastie ND, Caricasole A
  Gene. 1995
  PubMed ID: 8566784
   
  
• Allele-specific expression and total expression levels of imprinted genes during early mouse development: implications for imprinting mechanisms.
  Szabó PE, Mann JR
  Genes Dev. 1995
  PubMed ID: 8543154
   
  
• Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos.
  Sasaki H, Ferguson-Smith AC, Shum AS, Barton SC, Surani MA
  Development. 1995
  PubMed ID: 8575319
   
  
• Developmental regulation of genomic imprinting during gametogenesis.
  Villar AJ, Eddy EM, Pedersen RA
  Dev Biol. 1995
  PubMed ID: 7589806
   
  
• Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)
  Bates P, Fisher R, Ward A, Richardson L, Hill DJ, Graham CF
  Br J Cancer. 1995
  PubMed ID: 7577466
   
  
• Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse.
  Hatada I, Mukai T
  Nat Genet. 1995
  PubMed ID: 7550351
   
  
• Towards unravelling the Igf2/H19 imprinted domain.
  Viville S, Surani MA
  Bioessays. 1995
  PubMed ID: 7487965
   
  
• Programmed cell death in dystrophic (mdx) muscle is inhibited by IGF-II.
  Smith J, Fowkes G, Schofield PN
  Cell Death Differ. 1995
  PubMed ID: 17180029
   
  
• Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization.
  Kaneko-Ishino T, Kuroiwa Y, Miyoshi N, Kohda T, Suzuki R, Yokoyama M, Viville S, Barton SC, Ishino F, Surani MA
  Nat Genet. 1995
  PubMed ID: 7550314
   
  
• An enhancer deletion affects both H19 and Igf2 expression.
  Leighton PA, Saam JR, Ingram RS, Stewart CL, Tilghman SM
  Genes Dev. 1995
  PubMed ID: 7544754
   
  
• Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos.
  Bettenhausen B, Gossler A
  Genomics. 1995
  PubMed ID: 7490078
   
  
• Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.
  Harrison SM, Dunwoodie SL, Arkell RM, Lehrach H, Beddington RS
  Development. 1995
  PubMed ID: 7671812
   
  
• Biallelic expression of imprinted genes in the mouse germ line: implications for erasure, establishment, and mechanisms of genomic imprinting.
  Szabó PE, Mann JR
  Genes Dev. 1995
  PubMed ID: 7649473
   
  
• Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor.
  Schmidt B, Kiecke-Siemsen C, Waheed A, Braulke T, von Figura K
  J Biol Chem. 1995
  PubMed ID: 7797478
   
  
• Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis.
  Wang E, Wang J, Chin E, Zhou J, Bondy CA
  Endocrinology. 1995
  PubMed ID: 7750499
   
  
• IGF, type I IGF receptor and IGF-binding protein mRNA expression in the developing mouse lung.
  Schuller AG, van Neck JW, Beukenholdt RW, Zwarthoff EC, Drop SL
  J Mol Endocrinol. 1995
  PubMed ID: 7545402
   
  
• Disruption of imprinting caused by deletion of the H19 gene region in mice.
  Leighton PA, Ingram RS, Eggenschwiler J, Efstratiadis A, Tilghman SM
  Nature. 1995
  PubMed ID: 7536897
   
  
• H19 is imprinted in the choroid plexus and leptomeninges of the mouse foetus.
  Svensson K, Walsh C, Fundele R, Ohlsson R
  Mech Dev. 1995
  PubMed ID: 7669691
   
  
• Insulin-like growth factors.
  Schmid C
  Cell Biol Int. 1995
  PubMed ID: 7640658
   
  
• Differential biallelic activation of three insulin-like growth factor II promoters in the mouse central nervous system.
  Hu JF, Vu TH, Hoffman AR
  Mol Endocrinol. 1995
  PubMed ID: 7565809
   
  
• Purification and characterization of insulin-like growth factor II (IGF II) and an IGF II variant from human placenta.
  De Ceuninck F, Willeput J, Corvol M
  J Chromatogr B Biomed Appl. 1995
  PubMed ID: 7633596
   
  
• Coordinate regulation of Igf-2 and H19 in cultured cells.
  Eversole-Cire P, Ferguson-Smith AC, Surani MA, Jones PA
  Cell Growth Differ. 1995
  PubMed ID: 7794801
   
  
• Genomic imprinting of Mash2, a mouse gene required for trophoblast development.
  Guillemot F, Caspary T, Tilghman SM, Copeland NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A
  Nat Genet. 1995
  PubMed ID: 7773285
   
  
• The eed mutation disrupts anterior mesoderm production in mice.
  Faust C, Schumacher A, Holdener B, Magnuson T
  Development. 1995
  PubMed ID: 7768172
   
  
• Isolation of a cDNA for a growth factor of vascular endothelial cells from human lung cancer cells: its identity with insulin-like growth factor II.
  Hagiwara K, Kobayashi T, Tobita M, Kikyo N, Yazaki Y, Okabe T
  Jpn J Cancer Res. 1995
  PubMed ID: 7730145
   
  
• Chromatin structure and imprinting: developmental control of DNase-I sensitivity in the mouse insulin-like growth factor 2 gene.
  Feil R, Handel MA, Allen ND, Reik W
  Dev Genet. 1995
  PubMed ID: 8565330
   
  
• Identification of genes showing altered expression in preimplantation and early postimplantation parthenogenetic embryos.
  Mann M, Latham KE, Varmuza S
  Dev Genet. 1995
  PubMed ID: 8565329
   
  
• Characteristics of imprinted genes.
  Neumann B, Kubicka P, Barlow DP
  Nat Genet. 1995
  PubMed ID: 7704015
   
  
• Altered gene expression in murine branchial arches following in utero exposure to retinoic acid.
  Taylor LE, Bennett GD, Finnell RH
  J Craniofac Genet Dev Biol. 1995
  PubMed ID: 7601910
   
  
• Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality.
  Lau MM, Stewart CE, Liu Z, Bhatt H, Rotwein P, Stewart CL
  Genes Dev. 1994
  PubMed ID: 8001817
   
  
• Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.
  Wang ZQ, Fung MR, Barlow DP, Wagner EF
  Nature. 1994
  PubMed ID: 7984240
   
  
• Impressions of imprints.
  Ohlsson R, Barlow D, Surani A
  Trends Genet. 1994
  PubMed ID: 7871587
   
  
• Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.
  Terasawa H, Kohda D, Hatanaka H, Nagata K, Higashihashi N, Fujiwara H, Sakano K, Inagaki F
  EMBO J. 1994
  PubMed ID: 7527339
   
  
• Comparative analysis of Igf-2/H19 imprinted domain: identification of a highly conserved intergenic DNase I hypersensitive region.
  Koide T, Ainscough J, Wijgerde M, Surani MA
  Genomics. 1994
  PubMed ID: 7896263
   
  
• Discriminating translation of insulin-like growth factor-II (IGF-II) during mouse embryogenesis.
  Newell S, Ward A, Graham C
  Mol Reprod Dev. 1994
  PubMed ID: 7888164
   
  
• Disproportionate growth in mice with Igf-2 transgenes.
  Ward A, Bates P, Fisher R, Richardson L, Graham CF
  Proc Natl Acad Sci U S A. 1994
  PubMed ID: 7524092
   
  
• Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes.
  Feil R, Walter J, Allen ND, Reik W
  Development. 1994
  PubMed ID: 7607083
   
  
• Insulin-like growth factors-I and -II and their binding proteins during postnatal development of dwarf Snell mice before and during growth hormone and thyroxine therapy.
  van Buul-Offers SC, Bloemen RJ, Reijnen-Gresnigt MG, van Leiden HA, Hoogerbrugge CM, Van den Brande JL
  J Endocrinol. 1994
  PubMed ID: 7525829
   
  
• Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model.
  Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH
  Reprod Toxicol. 1994
  PubMed ID: 7841657
   
  
• Recombinant insulin-like growth factor-II inhibits the growth-stimulating effect of growth hormone on the liver of Snell dwarf mice.
  van Buul-Offers SC, Reijnen-Gresnigt MG, Hoogerbrugge CM, Bloemen RJ, Kuper CF, Van den Brande JL
  Endocrinology. 1994
  PubMed ID: 7520865
   
  
• Insulin-like growth factor II promotes in vitro cholinergic development of mouse septal neurons: comparison with the effects of insulin-like growth factor I.
  Konishi Y, Takahashi K, Chui DH, Rosenfeld RG, Himeno M, Tabira T
  Brain Res. 1994
  PubMed ID: 7953654
   
  
• Expression and methylation of imprinted genes during in vitro differentiation of mouse parthenogenetic and androgenetic embryonic stem cell lines.
  Szabó P, Mann JR
  Development. 1994
  PubMed ID: 8050371
   
  
• A functional analysis of imprinting in parthenogenetic embryonic stem cells.
  Allen ND, Barton SC, Hilton K, Norris ML, Surani MA
  Development. 1994
  PubMed ID: 8050357
   
  
• Genetic mapping of 40 cDNA clones on the mouse genome by PCR.
  Ko MS, Wang X, Horton JH, Hagen MD, Takahashi N, Maezaki Y, Nadeau JH
  Mamm Genome. 1994
  PubMed ID: 8043949
   
  
• The non-viability of uniparental mouse conceptuses correlates with the loss of the products of imprinted genes.
  Walsh C, Glaser A, Fundele R, Ferguson-Smith A, Barton S, Surani MA, Ohlsson R
  Mech Dev. 1994
  PubMed ID: 8068549
   
  
• Mechanisms of insulin-like growth factor (IGF)-II-induced IGF-I receptor down-regulation in BC3H-1 muscle cells.
  Rosenthal SM, Brown EJ
  J Endocrinol. 1994
  PubMed ID: 8014604
   
  
• Insulin family growth factors have specific effects on protein synthesis in preimplantation mouse embryos.
  Shi CZ, Collins HW, Buettger CW, Garside WT, Matschinsky FM, Heyner S
  Mol Reprod Dev. 1994
  PubMed ID: 8011324
   
  
• Expression of insulin-like growth factors I and II in conceptuses from normal and diabetic mice.
  Chernicky CL, Redline RW, Tan HQ, Gwatkin RB, Johnson TR, Ilan J, Ilan J
  Mol Reprod Dev. 1994
  PubMed ID: 8011322
   
  
• Spatially restricted imprinting of mouse chromosome 7.
  Villar AJ, Pedersen RA
  Mol Reprod Dev. 1994
  PubMed ID: 8185928
   
  
• Allele specific inactivation of insulin 1 and 2, in the mouse yolk sac, indicates imprinting.
  Giddings SJ, King CD, Harman KW, Flood JF, Carnaghi LR
  Nat Genet. 1994
  PubMed ID: 8012396
   
  
• The search for imprinted genes.
  Bartolomei MS
  Nat Genet. 1994
  PubMed ID: 8012378
   
  
• Igf2r and Igf2 gene expression in androgenetic, gynogenetic, and parthenogenetic preimplantation mouse embryos: absence of regulation by genomic imprinting.
  Latham KE, Doherty AS, Scott CD, Schultz RM
  Genes Dev. 1994
  PubMed ID: 8314083
   
  
• Biological actions of IGFs in mammalian development.
  Heyner S, Garside WT
  Bioessays. 1994
  PubMed ID: 8141806
   
  
• Insulin-like growth factor II (IGF-II) and the IGF-II/mannose-6-phosphate receptor: the myth continues.
  Kiess W, Yang Y, Kessler U, Hoeflich A
  Horm Res. 1994
  PubMed ID: 8088706
   
  
• Parental imprinting and the IGF2 gene.
  Ekström TJ
  Horm Res. 1994
  PubMed ID: 7868070
   
  
• Constitutional relaxation of insulin-like growth factor II gene imprinting associated with Wilms' tumour and gigantism.
  Ogawa O, Becroft DM, Morison IM, Eccles MR, Skeen JE, Mauger DC, Reeve AE
  Nat Genet. 1993
  PubMed ID: 8298652
   
  
• Role for DNA methylation in genomic imprinting.
  Li E, Beard C, Jaenisch R
  Nature. 1993
  PubMed ID: 8247133
   
  
• Genomic imprinting. Silence of the genes.
  Surani MA
  Nature. 1993
  PubMed ID: 8247120
   
  
• Differential expression of the human, mouse and rat IGF-II genes.
  Holthuizen PE, Cleutjens CB, Veenstra GJ, van der Lee FM, Koonen-Reemst AM, Sussenbach JS
  Regul Pept. 1993
  PubMed ID: 8265819
   
  
• Role of insulin-like growth factors in embryonic and postnatal growth.
  Baker J, Liu JP, Robertson EJ, Efstratiadis A
  Cell. 1993
  PubMed ID: 8402902
   
  
• Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r).
  Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A
  Cell. 1993
  PubMed ID: 8402901
   
  
• Differential expression of insulin-like growth factor-II in specific regions of the late (post day 9.5) murine placenta.
  Redline RW, Chernicky CL, Tan HQ, Ilan J, Ilan J
  Mol Reprod Dev. 1993
  PubMed ID: 8257562
   
  
• Functions of the IGFs in early mammalian development.
  Heyner S, Shi CZ, Garside WT, Smith RM
  Mol Reprod Dev. 1993
  PubMed ID: 8398122
   
  
• Expression of IGF ligand and receptor genes during preimplantation mammalian development.
  Schultz GA, Hahnel A, Arcellana-Panlilio M, Wang L, Goubau S, Watson A, Harvey M
  Mol Reprod Dev. 1993
  PubMed ID: 8398121
   
  
• Identification of an antisense transcript from the IGF-II locus in mouse.
  Rivkin M, Rosen KM, Villa-Komaroff L
  Mol Reprod Dev. 1993
  PubMed ID: 8398118
   
  
• Parental imprinting of an Igf-2 transgene.
  Lee JE, Tantravahi U, Boyle AL, Efstratiadis A
  Mol Reprod Dev. 1993
  PubMed ID: 8398116
   
  
• Specific, temporally regulated expression of the insulin-like growth factor II gene during muscle cell differentiation.
  Rosen KM, Wentworth BM, Rosenthal N, Villa-Komaroff L
  Endocrinology. 1993
  PubMed ID: 8393762
   
  
• The IGFs and their binding proteins in murine development.
  Murphy LJ, Barron DJ
  Mol Reprod Dev. 1993
  PubMed ID: 7691099
   
  
• Allele-specific replication timing of imprinted gene regions.
  Kitsberg D, Selig S, Brandeis M, Simon I, Keshet I, Driscoll DJ, Nicholls RD, Cedar H
  Nature. 1993
  PubMed ID: 8332218
   
  
• Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.
  Filson AJ, Louvi A, Efstratiadis A, Robertson EJ
  Development. 1993
  PubMed ID: 8076514
   
  
• Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6.
  Bach LA, Hsieh S, Sakano K, Fujiwara H, Perdue JF, Rechler MM
  J Biol Chem. 1993
  PubMed ID: 7683646
   
  
• Transactivation of mouse insulin-like growth factor II (IGF-II) gene promoters by the AP-1 complex.
  Caricasole A, Ward A
  Nucleic Acids Res. 1993
  PubMed ID: 8493103
   
  
• Relaxation of imprinted genes in human cancer.
  Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE, Feinberg AP
  Nature. 1993
  PubMed ID: 8385745
   
  
• Gtx: a novel murine homeobox-containing gene, expressed specifically in glial cells of the brain and germ cells of testis, has a transcriptional repressor activity in vitro for a serum-inducible promoter.
  Komuro I, Schalling M, Jahn L, Bodmer R, Jenkins NA, Copeland NG, Izumo S
  EMBO J. 1993
  PubMed ID: 8096811
   
  
• Anatomy of the human ovarian insulin-like growth factor system.
  Zhou J, Bondy C
  Biol Reprod. 1993
  PubMed ID: 7680905
   
  
• Structural analysis of the human insulin-like growth factor-II P3 promoter.
  Raizis AM, Eccles MR, Reeve AE
  Biochem J. 1993
  PubMed ID: 8424751
   
  
• Possible autocrine/paracrine actions of insulin-like growth factors during embryonic development: expression and action of IGFs in undifferentiated P19 cells.
  Eicher DJ, Moats-Staats BM, Stiles AD, D'Ercole AJ
  Dev Genet. 1993
  PubMed ID: 8358865
   
  
• Mapping of glutathione transferase (GST) genes in the rat.
  Klinga-Levan K, Andersson A, Hanson C, Ridderström M, Stenberg G, Mannervik B, Vajdy M, Szpirer J, Szpirer C, Levan G
  Hereditas. 1993
  PubMed ID: 8144363
   
  
• Allele-specific structures in the mouse Igf2-H19 domain.
  Ariel M, Selig S, Brandeis M, Kitsberg D, Kafri T, Weiss A, Keshet I, Razin A, Cedar H
  Cold Spring Harb Symp Quant Biol. 1993
  PubMed ID: 7956043
   
  
• Parental imprinting of the H19 and Igf2 genes in the mouse.
  Tilghman SM, Bartolomei MS, Webber AL, Brunkow ME, Saam J, Leighton PA, Pfeifer K, Zemel S
  Cold Spring Harb Symp Quant Biol. 1993
  PubMed ID: 7956041
   
  
• Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.
  Sasaki H, Jones PA, Chaillet JR, Ferguson-Smith AC, Barton SC, Reik W, Surani MA
  Genes Dev. 1992
  PubMed ID: 1383088
   
  
• Differential expression of insulin-like growth factors I and II (IGF I and II), mRNA, peptide and binding protein 1 during mouse palate development: comparison with TGF beta peptide distribution.
  Ferguson MW, Sharpe PM, Thomas BL, Beck F
  J Anat. 1992
  PubMed ID: 1284245
   
  
• IGF-2 stimulates growth and metabolism of early mouse embryos.
  Harvey MB, Kaye PL
  Mech Dev. 1992
  PubMed ID: 1457378
   
  
• Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2.
  Zemel S, Bartolomei MS, Tilghman SM
  Nat Genet. 1992
  PubMed ID: 1303252
   
  
• The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.
  Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, Copeland NG, Rabbitts TH
  J Mol Biol. 1992
  PubMed ID: 1507224
   
  
• Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos.
  Varmuza S, Tate P
  Mol Reprod Dev. 1992
  PubMed ID: 1497882
   
  
• Rat gene mapping using PCR-analyzed microsatellites.
  Serikawa T, Kuramoto T, Hilbert P, Mori M, Yamada J, Dubay CJ, Lindpainter K, Ganten D, Guénet JL, Lathrop GM
  Genetics. 1992
  PubMed ID: 1628813
   
  
• Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
  Rappolee DA, Sturm KS, Behrendtsen O, Schultz GA, Pedersen RA, Werb Z
  Genes Dev. 1992
  PubMed ID: 1317321
   
  
• Temporal and quantitative analysis of myogenic regulatory and growth factor gene expression in the developing mouse embryo.
  Hannon K, Smith CK, Bales KR, Santerre RF
  Dev Biol. 1992
  PubMed ID: 1374351
   
  
• The identification of O-glycosylated precursors of insulin-like growth factor II.
  Hudgins WR, Hampton B, Burgess WH, Perdue JF
  J Biol Chem. 1992
  PubMed ID: 1569071
   
  
• Induction and peak gene expression of insulin-like growth factor II follow that of myogenin during differentiation of BC3H-1 muscle cells.
  Brown EJ, Hsiao D, Rosenthal SM
  Biochem Biophys Res Commun. 1992
  PubMed ID: 1314574
   
  
• Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III.
  Ding L, Becker AB, Suzuki A, Roth RA
  J Biol Chem. 1992
  PubMed ID: 1733942
   
  
• Low-amplitude, low-frequency electric field-stimulated bone cell proliferation may in part be mediated by increased IGF-II release.
  Fitzsimmons RJ, Strong DD, Mohan S, Baylink DJ
  J Cell Physiol. 1992
  PubMed ID: 1730789
   
  
• Polymerase chain reaction (PCR) for detection of ApaI polymorphism at the insulin like growth factor II gene (IGF2).
  Tadokoro K, Fujii H, Inoue T, Yamada M
  Nucleic Acids Res. 1991
  PubMed ID: 1684848
   
  
• Specific endonucleolytic cleavage of IGF-II mRNAs.
  Meinsma D, Holthuizen PE, Van den Brande JL, Sussenbach JS
  Biochem Biophys Res Commun. 1991
  PubMed ID: 1656956
   
  
• Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins.
  Roghani M, Lassarre C, Zapf J, Povoa G, Binoux M
  J Clin Endocrinol Metab. 1991
  PubMed ID: 1714916
   
  
• Parental imprinting of the mouse H19 gene.
  Bartolomei MS, Zemel S, Tilghman SM
  Nature. 1991
  PubMed ID: 1709450
   
  
• Parental imprinting of the mouse insulin-like growth factor II gene.
  DeChiara TM, Robertson EJ, Efstratiadis A
  Cell. 1991
  PubMed ID: 1997210
   
  
• Mutants of human insulin-like growth factor II with altered affinities for the type 1 and type 2 insulin-like growth factor receptor.
  Bürgisser DM, Roth BV, Giger R, Lüthi C, Weigl S, Zarn J, Humbel RE
  J Biol Chem. 1991
  PubMed ID: 1845984
   
  
• Evolution of insulin-like growth factor II: characterization of the mouse IGF-II gene and identification of two pseudo-exons.
  Rotwein P, Hall LJ
  DNA Cell Biol. 1990
  PubMed ID: 1702294
   
  
• A molecular genetic linkage map of mouse chromosome 7.
  Saunders AM, Seldin MF
  Genomics. 1990
  PubMed ID: 1981054
   
  
• Expression of genes for insulin and insulin-like growth factors and receptors in early postimplantation mouse embryos and embryonal carcinoma cells.
  Telford NA, Hogan A, Franz CR, Schultz GA
  Mol Reprod Dev. 1990
  PubMed ID: 1701096
   
  
• Pattern of the insulin-like growth factor II gene expression during early mouse embryogenesis.
  Lee JE, Pintar J, Efstratiadis A
  Development. 1990
  PubMed ID: 1964408
   
  
• The primary structure of the rat insulin-like growth factor II gene region.
  Ikejiri K, Ueno T, Matsuguchi T, Takahashi K, Endo H, Yamamoto M
  Biochim Biophys Acta. 1990
  PubMed ID: 2383591
   
  
• A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.
  Bastian H, Gruss P
  EMBO J. 1990
  PubMed ID: 1971786
   
  
• A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.
  DeChiara TM, Efstratiadis A, Robertson EJ
  Nature. 1990
  PubMed ID: 2330056
   
  
• Functional analysis of multiple promoters of the rat insulin-like factor II gene.
  Matsuguchi T, Takahashi K, Ikejiri K, Ueno T, Endo H, Yamamoto M
  Biochim Biophys Acta. 1990
  PubMed ID: 2322575
   
  
• Multiple polyadenylation sites in a large 3'-most exon of the rat insulin-like growth factor II gene.
  Ueno T, Takahashi K, Matsuguchi T, Ikejiri K, Endo H, Yamamoto M
  Biochim Biophys Acta. 1989
  PubMed ID: 2477062
   
  
• Structure and activity dependence of recombinant human insulin-like growth factor II on disulfide bond pairing.
  Smith MC, Cook JA, Furman TC, Occolowitz JL
  J Biol Chem. 1989
  PubMed ID: 2722836
   
  
• Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors.
  Brown AL, Chiariotti L, Orlowski CC, Mehlman T, Burgess WH, Ackerman EJ, Bruni CB, Rechler MM
  J Biol Chem. 1989
  PubMed ID: 2538475
   
  
• Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation.
  Tollefsen SE, Sadow JL, Rotwein P
  Proc Natl Acad Sci U S A. 1989
  PubMed ID: 2537977
   
  
• Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids.
  Rosenfeld RG, Pham H, Conover CA, Hintz RL, Baxter RC
  J Clin Endocrinol Metab. 1989
  PubMed ID: 2465304
   
  
• Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors.
  Wang JF, Hampton B, Mehlman T, Burgess WH, Rechler MM
  Biochem Biophys Res Commun. 1988
  PubMed ID: 2974285
   
  
• Structure of the rat insulin-like growth factor II transcriptional unit: heterogeneous transcripts are generated from two promoters by use of multiple polyadenylation sites and differential ribonucleic acid splicing.
  Chiariotti L, Brown AL, Frunzio R, Clemmons DR, Rechler MM, Bruni CB
  Mol Endocrinol. 1988
  PubMed ID: 3221878
   
  
• Transcriptional deviation of the rat insulin-like growth factor II gene initiated at three alternative leader-exons between neonatal tissues and ascites hepatomas.
  Ueno T, Takahashi K, Matsuguchi T, Endo H, Yamamoto M
  Biochim Biophys Acta. 1988
  PubMed ID: 3167060
   
  
• Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein.
  de Pagter-Holthuizen P, Jansen M, van der Kammen RA, van Schaik FM, Sussenbach JS
  Biochim Biophys Acta. 1988
  PubMed ID: 3167054
   
  
• Isolation of an insulin-like growth factor II cDNA with a unique 5' untranslated region from human placenta.
  Shen SJ, Daimon M, Wang CY, Jansen M, Ilan J
  Proc Natl Acad Sci U S A. 1988
  PubMed ID: 2450353
   
  
• A new leader exon identified in the rat insulin-like growth factor II gene.
  Ueno T, Takahashi K, Matsuguchi T, Endo H, Yamamoto M
  Biochem Biophys Res Commun. 1987
  PubMed ID: 3453119
   
  
• A new 5'-non-coding region for human placental insulin-like growth factor II mRNA expression.
  Le Bouc Y, Noguiez P, Sondermeijer P, Dreyer D, Girard F, Binoux M
  FEBS Lett. 1987
  PubMed ID: 3653397
   
  
• Tissue-specific expression of insulin-like growth factor II mRNAs with distinct 5' untranslated regions.
  Irminger JC, Rosen KM, Humbel RE, Villa-Komaroff L
  Proc Natl Acad Sci U S A. 1987
  PubMed ID: 3476948
   
  
• Tissue-specific and developmentally regulated transcription of the insulin-like growth factor 2 gene.
  Gray A, Tam AW, Dull TJ, Hayflick J, Pintar J, Cavenee WK, Koufos A, Ullrich A
  DNA. 1987
  PubMed ID: 3652904
   
  
• Human insulin-like growth factor I and II messenger RNA: isolation of complementary DNA and analysis of expression.
  Rall LB, Scott J, Bell GI
  Methods Enzymol. 1987
  PubMed ID: 3683205
   
  
• Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.
  Frunzio R, Chiariotti L, Brown AL, Graham DE, Rechler MM, Bruni CB
  J Biol Chem. 1986
  PubMed ID: 3023383
   
  
• Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family.
  Soares MB, Turken A, Ishii D, Mills L, Episkopou V, Cotter S, Zeitlin S, Efstratiadis A
  J Mol Biol. 1986
  PubMed ID: 2438416
   
  
• Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor.
  Stempien MM, Fong NM, Rall LB, Bell GI
  DNA. 1986
  PubMed ID: 3780370
   
  
• Organization of the human genes for insulin-like growth factors I and II.
  de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS
  FEBS Lett. 1986
  PubMed ID: 3002851
   
  
• Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA.
  Soares MB, Ishii DN, Efstratiadis A
  Nucleic Acids Res. 1985
  PubMed ID: 3889836
   
  
• Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant.
  Jansen M, van Schaik FM, van Tol H, Van den Brande JL, Sussenbach JS
  FEBS Lett. 1985
  PubMed ID: 3881277
   
  
• Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor.
  Whitfield HJ, Bruni CB, Frunzio R, Terrell JE, Nissley SP, Rechler MM
  Nature. 1984
  PubMed ID: 6390212
   
  
• Insulin-like growth factor II precursor gene organization in relation to insulin gene family.
  Dull TJ, Gray A, Hayflick JS, Ullrich A
  Nature. 1984
  PubMed ID: 6382022
   
  
• Sequence of a cDNA clone encoding human preproinsulin-like growth factor II.
  Bell GI, Merryweather JP, Sanchez-Pescador R, Stempien MM, Priestley L, Scott J, Rall LB
  Nature. 1984
  PubMed ID: 6382021
   
  
• Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.
  Blundell TL, Bedarkar S, Humbel RE
  Fed Proc. 1983
  PubMed ID: 6189745
   
  
• Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.
  Marquardt H, Todaro GJ, Henderson LE, Oroszlan S
  J Biol Chem. 1981
  PubMed ID: 7016879
   
  
• Primary structure of human insulin-like growth factor II.
  Rinderknecht E, Humbel RE
  FEBS Lett. 1978
  PubMed ID: 658418
   
  

Relevant resources:

Comment on this Page
Privacy Statement  |   Copyright, Warranty & Disclaimer  |   Contact Us
Copyright © 2001-2011, T1DBase | Version 4.8 | PMID:20937630
Printed on Fri February 10, 2012