T1DBase - A Bioinformatics Resource for Type 1 Diabetes Researchers

Gene Description:

heat shock protein 1 (chaperonin 10), related sequence 1; heat shock protein 1 (chaperonin 10); heat shock 10kDa protein 1 (chaperonin 10)

Synonyms:

Hspe1-rs1, Cpn10, HSP10, Cpn10-rs1, Hspe1, HSPE1, CPN10, EG628438, EPF, GROES

Orthologs:

Human HSPE1 (protein-coding), Mouse Hspe1-rs1 (pseudo), Rat Hspe1 (protein-coding)

Sources

(Human) GRCh37 - chr2:198364718..198368187 (3.47 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:53895333..53898421 (39 kb) View in Genome Browser

HaemAtlas Expression Table for HSPE1:

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
					no data	no data	no data

Expression Legend

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Table for HSPE1:

The HSPE1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
HSPE1	C14orf1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	ZHX1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	GABARAP	IntAct	empirical	20562859
HSPE1	GABARAPL2	IntAct	empirical	20562859
HSPE1	CRMP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	DLG4	IntAct	empirical	19455133
HSPE1	EEF1A1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	EPB41	IntAct	empirical	17353931
HSPE1	ALDH2	HPRD, BioGRID	empirical	12387818
HSPE1	FHIT	IntAct	empirical	18319262
HSPE1	KPNA6	Sanger Interaction Map	predicted	15345047
HSPE1	GABARAPL1	IntAct	empirical	20562859
HSPE1	FTSJ1	IntAct	empirical	17353931
HSPE1	DSTYK	IntAct, BioGRID	empirical	17353931
HSPE1	GBP2	HPRD, IntAct, BioGRID	empirical	16169070
HSPE1	HLA-B	IntAct	empirical	17353931
HSPE1	HSPD1	HPRD, IntAct, BioGRID	empirical	11050098 10205158 12387818 19004824 18319262
HSPE1	APLP1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	ILK	IntAct	empirical	17353931
HSPE1	GBP7	MINT	empirical	16169070
HSPE1	MPG	IntAct	empirical	17353931
HSPE1	RIF1	IntAct	empirical	16169070
HSPE1	LRIF1	HPRD, MINT	empirical	16169070
HSPE1	SAT1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	SLC2A4	IntAct	empirical	16396496
HSPE1	STK3	IntAct	empirical	21988832
HSPE1	TLE1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	TRAF6	IntAct	empirical	17353931
HSPE1	UBC	BioGRID	empirical	21139048 21890473 21906983
HSPE1	VHL	IntAct	empirical	17353931
HSPE1	FBXO11	IntAct	empirical	17353931
HSPE1	CASP3	HPRD, BioGRID	empirical	10205158
HSPE1	TNFRSF14	IntAct	empirical	17353931
HSPE1	TNFRSF10D	IntAct	empirical	17353931
HSPE1	UNC119	HPRD, MINT, IntAct, BioGRID	empirical	16169070
HSPE1	ATG5	IntAct	empirical	17353931
HSPE1	IKBKE	IntAct	empirical	17353931
HSPE1	KIAA0101	BioGRID	empirical	21628590

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 11

Type 1 Diabetes Publications: 1

Publications: 63

The first identification of lysine malonylation substrates and its regulatory enzyme.
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y
Mol Cell Proteomics. 2011
PubMed ID: 21908771
Macromolecular crowding extended to a heptameric system: the Co-chaperonin protein 10.
Aguilar X, F Weise C, Sparrman T, Wolf-Watz M, Wittung-Stafshede P
Biochemistry. 2011
PubMed ID: 21375247
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Involvement of HSP10 during the ovarian follicular development of polycystic ovary syndrome: Study in both human ovaries and cultured mouse follicles.
Fan L, Fan L, Ling J, Ma X, Cui YG, Liu JY
Gynecol Endocrinol. 2009
PubMed ID: 19903031
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Chaperonin 10 as an endothelial-derived differentiation factor: role of glycogen synthase kinase-3.
Dobocan MC, Sadvakassova G, Congote LF
J Cell Physiol. 2009
PubMed ID: 19142874
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh SS, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner K
J Biol Chem. 2009
PubMed ID: 19004824
Recombinant EPF/chaperonin 10 promotes the survival of O4-positive pro-oligodendrocytes prepared from neonatal rat brain.
McCombe PA
Cell Stress Chaperones. 2008
PubMed ID: 18465204
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.
Apetri AC, Horwich AL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18987317
Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas.
Têtu B, Popa I, Bairati I, L'Esperance S, Bachvarova M, Plante M, Harel F, Bachvarov D
Mod Pathol. 2008
PubMed ID: 18500265
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM
J Biol Chem. 2008
PubMed ID: 18319262
Fibril formation of hsp10 homologue proteins and determination of fibril core regions: differences in fibril core regions dependent on subtle differences in amino acid sequence.
Yagi H, Sato A, Yoshida A, Hattori Y, Hara M, Shimamura J, Sakane I, Hongo K, Mizobata T, Kawata Y
J Mol Biol. 2008
PubMed ID: 18329043
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Heparanase gene haplotype (CGC) is associated with stage of disease in patients with ovarian carcinoma.
Ralph S, Brenchley PE, Summers A, Rosa DD, Swindell R, Jayson GC
Cancer Sci. 2007
PubMed ID: 17419711
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D
Mol Syst Biol. 2007
PubMed ID: 17353931
Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
Bross P, Li Z, Hansen J, Hansen JJ, Nielsen MN, Corydon TJ, Georgopoulos C, Ang D, Lundemose JB, Niezen-Koning K, Eiberg H, Yang H, Kølvraa S, Bolund L, Gregersen N
J Hum Genet. 2007
PubMed ID: 17072495
Kinetic folding and assembly mechanisms differ for two homologous heptamers.
Luke K, Perham M, Wittung-Stafshede P
J Mol Biol. 2006
PubMed ID: 16979655
Detection and identification of heat shock protein 10 as a biomarker in colorectal cancer by protein profiling.
Melle C, Bogumil R, Ernst G, Schimmel B, Bleul A, von Eggeling F
Proteomics. 2006
PubMed ID: 16502466
Heat shock protein 10 and signal transduction: a "capsula eburnea" of carcinogenesis?
Czarnecka AM, Campanella C, Zummo G, Cappello F
Cell Stress Chaperones. 2006
PubMed ID: 17278877
Dissecting homo-heptamer thermodynamics by isothermal titration calorimetry: entropy-driven assembly of co-chaperonin protein 10.
Luke K, Apiyo D, Wittung-Stafshede P
Biophys J. 2005
PubMed ID: 16100270
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Interface mutation in heptameric co-chaperonin protein 10 destabilizes subunits but not interfaces.
Brown C, Liao J, Wittung-Stafshede P
Arch Biochem Biophys. 2005
PubMed ID: 15978542
A strategy for high-resolution protein identification in surface-enhanced laser desorption/ionization mass spectrometry: calgranulin A and chaperonin 10 as protein markers for endometrial carcinoma.
Guo J, Yang EC, Desouza L, Diehl G, Rodrigues MJ, Romaschin AD, Colgan TJ, Siu KW
Proteomics. 2005
PubMed ID: 15816004
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.
Johnson BJ, Le TT, Dobbin CA, Banovic T, Howard CB, Flores Fde M, Vanags D, Naylor DJ, Hill GR, Suhrbier A
J Biol Chem. 2005
PubMed ID: 15546885
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
Cappello F, David S, Rappa F, Bucchieri F, Marasà L, Bartolotta TE, Farina F, Zummo G
BMC Cancer. 2005
PubMed ID: 16253146
Structural stability of oligomeric chaperonin 10: the role of two beta-strands at the N and C termini in structural stabilization.
Sakane I, Ikeda M, Matsumoto C, Higurashi T, Inoue K, Hongo K, Mizobata T, Kawata Y
J Mol Biol. 2004
PubMed ID: 15544816
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
HSP10 selective preference for myeloid and megakaryocytic precursors in normal human bone marrow.
Cappello F, Tripodo C, Farina F, Franco V, Zummo G
Eur J Histochem. 2004
PubMed ID: 15590416
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW
Nat Biotechnol. 2004
PubMed ID: 15146197
Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway.
Lin KM, Hollander JM, Kao VY, Lin B, Macpherson L, Dillmann WH
FASEB J. 2004
PubMed ID: 15059967
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.
Shan YX, Yang TL, Mestril R, Wang PH
J Biol Chem. 2003
PubMed ID: 12970367
Probing the interface in a human co-chaperonin heptamer: residues disrupting oligomeric unfolded state identified.
Guidry JJ, Shewmaker F, Maskos K, Landry S, Wittung-Stafshede P
BMC Biochem. 2003
PubMed ID: 14525625
Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.
Shan YX, Liu TJ, Su HF, Samsamshariat A, Mestril R, Wang PH
J Mol Cell Cardiol. 2003
PubMed ID: 12967636
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix.
Cappello F, Bellafiore M, David S, Anzalone R, Zummo G
Cancer Lett. 2003
PubMed ID: 12860287
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, Børglum AD, Mogensen J, Kristiansen K, Bolund L, Gregersen N
Hum Genet. 2003
PubMed ID: 12483302
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli.
Lee KH, Kim HS, Jeong HS, Lee YS
Biochem Biophys Res Commun. 2002
PubMed ID: 12387818
Type I collagen synthesis by human osteoblasts in response to placental lactogen and chaperonin 10, a homolog of early-pregnancy factor.
Mansell JP, Yarram SJ, Brown NL, Sandy JR
In Vitro Cell Dev Biol Anim. 2002
PubMed ID: 12703979
Low stability for monomeric human chaperonin protein 10: interprotein interactions contribute majority of oligomer stability.
Guidry JJ, Wittung-Stafshede P
Arch Biochem Biophys. 2002
PubMed ID: 12220543
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
Hansen JJ, Dürr A, Cournu-Rebeix I, Georgopoulos C, Ang D, Nielsen MN, Davoine CS, Brice A, Fontaine B, Gregersen N, Bross P
Am J Hum Genet. 2002
PubMed ID: 11898127
Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.
Parissi V, Calmels C, De Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S
J Virol. 2001
PubMed ID: 11689615
Creation of genome-wide protein expression libraries using random activation of gene expression.
Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M
Nat Biotechnol. 2001
PubMed ID: 11329013
Disrupting Il13 impairs production of IL-4 specified by the linked allele.
Guo L, Hu-Li J, Zhu J, Pannetier C, Watson C, McKenzie GJ, McKenzie AN, Paul WE
Nat Immunol. 2001
PubMed ID: 11323701
The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.
Richardson A, Schwager F, Landry SJ, Georgopoulos C
J Biol Chem. 2001
PubMed ID: 11050098
The murine chaperonin 10 gene family contains an intronless, putative gene for early pregnancy factor, Cpn10-rs1.
Fletcher BH, Cassady AI, Summers KM, Cavanagh AC
Mamm Genome. 2001
PubMed ID: 11210183
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S
EMBO J. 1999
PubMed ID: 10205158
Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.
Agarwal SK, Guru SC, Heppner C, Erdos MR, Collins RM, Park SY, Saggar S, Chandrasekharappa SC, Collins FS, Spiegel AM, Marx SJ, Burns AL
Cell. 1999
PubMed ID: 9989505
Mapping and characterization of the eukaryotic early pregnancy factor/chaperonin 10 gene family.
Summers KM, Fletcher BH, Macaranas DD, Somodevilla-Torres MJ, Murphy RM, Osborne MJ, Spurr NK, Cassady AI, Cavanagh AC
Somat Cell Mol Genet. 1998
PubMed ID: 10763410
The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter.
Ryan MT, Herd SM, Sberna G, Samuel MM, Hoogenraad NJ, Høj PB
Gene. 1997
PubMed ID: 9322735
Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10.
Legname G, Fossati G, Gromo G, Monzini N, Marcucci F, Modena D
FEBS Lett. 1995
PubMed ID: 7698325
Isolation, sequence analysis and characterization of a cDNA encoding human chaperonin 10.
Chen JJ, McNealy DJ, Dalal S, Androphy EJ
Biochim Biophys Acta. 1994
PubMed ID: 7916212
Identification and cloning of human chaperonin 10 homologue.
Monzini N, Legname G, Marcucci F, Gromo G, Modena D
Biochim Biophys Acta. 1994
PubMed ID: 7914093
The purification of early-pregnancy factor to homogeneity from human platelets and identification as chaperonin 10.
Cavanagh AC, Morton H
Eur J Biochem. 1994
PubMed ID: 7912672
Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence.
Ryan MT, Hoogenraad NJ, Høj PB
FEBS Lett. 1994
PubMed ID: 7904573
The complete primary structure of rat chaperonin 10 reveals a putative beta alpha beta nucleotide-binding domain with homology to p21ras.
Hartman DJ, Hoogenraad NJ, Condron R, Høj PB
Biochim Biophys Acta. 1993
PubMed ID: 8101099
Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro.
Hartman DJ, Hoogenraad NJ, Condron R, Høj PB
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1348860

Model Organism Phenotype Links

	Human	Mouse	Rat
Entrez Gene	3336	628438	25462
EnsEMBL Gene(s)	ENSG00000115541	N/A	ENSRNOG00000014868
Unigene	Hs.1197	N/A	Rn.106093
Homologene	HSPE1	Hspe1-rs1	Hspe1
OMIM	600141	N/A	N/A
GeneCards	HSPE1	N/A	N/A
Beta Cell Genomics	DT.100044974 DT.453986 DT.92461991 DT.95260889	N/A	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000233893	N/A	N/A
WikiGenes	3336	628438	25462

Relevant resources: