APLP1

Summary Top Help

Gene Description:

amyloid beta (A4) precursor-like protein 1

Synonyms:

Aplp1, RGD1561211, APLP, APLP1, Aplp1_retired

Orthologs:

Human APLP1 (protein-coding), Mouse Aplp1 (protein-coding), Rat Aplp1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr19:36359138..36370699 (11.56 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:31220001..31230580 (10.58 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:85390225..85399362 (9.14 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for APLP1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for APLP1:

The APLP1 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
APLP1	TOM1	IntAct	empirical	14563850
APLP1	CDK4	BioGRID	empirical	21900206
APLP1	MPHOSPH6	HPRD, MINT, IntAct	empirical	16169070
APLP1	CDKN1A	BioGRID	empirical	21900206
APLP1	APBB3	BioGRID	empirical	10081969
APLP1	CDKN2C	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	SPON1	IntAct	empirical	14983046
APLP1	UTP14A	HPRD, MINT, IntAct, BioGRID	empirical	16169070 15383276
APLP1	RCC1	BioGRID	empirical	21900206
APLP1	TOE1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	CSNK2B	BioGRID	empirical	21900206
APLP1	CNTN4	IntAct	empirical	18272596
APLP1	PRUNE2	IntAct	empirical	17934213
APLP1	DAB1	HPRD, IntAct, BioGRID	empirical	10460257
APLP1	DAB2	BioGRID	empirical	11247302
APLP1	EEF1A1	MINT	empirical	15383276
APLP1	FOS	IntAct	empirical	20195357
APLP1	GDF9	MINT	empirical	15383276
APLP1	GSTM4	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	ANXA7	BioGRID	empirical	21900206
APLP1	HLA-DQA1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	APBB1	HPRD, BioGRID	empirical	8894693 10081969
APLP1	APLP1	IntAct	empirical	16193067
APLP1	HSPE1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	APLP2	IntAct	empirical	16193067
APLP1	APP	IntAct	empirical	16193067 17934213
APLP1	ARRB1	IntAct	empirical	17620599
APLP1	NACA	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	PNP	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	CNTN3	IntAct	empirical	18272596
APLP1	CNTN5	IntAct	empirical	18272596
APLP1	PCDH18	IntAct	empirical	11716507
APLP1	CRCT1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	PHF10	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	LRIF1	MINT	empirical	15383276
APLP1	PCDHA4	HPRD, MINT, IntAct	empirical	16169070
APLP1	PRNP	HPRD, MINT	empirical	15146195
APLP1	KIAA1377	MINT	empirical	15383276
APLP1	RAP1B	BioGRID	empirical	21900206
APLP1	SLC5A7	IntAct	empirical	17709753
APLP1	SAT1	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	STX5	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	TCF21	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	TK1	HPRD, MINT, IntAct	empirical	16169070
APLP1	TMSB4X	HPRD, IntAct, BioGRID	empirical	16169070
APLP1	VGF	IntAct	empirical	17934213
APLP1	VIM	BioGRID	empirical	21900206
APLP1	ZNF24	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	RBM48	MINT	empirical	15383276
APLP1	ING5	MINT	empirical	15383276
APLP1	RASAL1	IntAct	empirical	17934213
APLP1	PPAP2A	IntAct	empirical	17934213
APLP1	PPAP2C	IntAct	empirical	17934213
APLP1	TSC22D1	HPRD, MINT, IntAct, BioGRID	empirical	16169070 21900206
APLP1	EIF2S2	HPRD, MINT, IntAct, BioGRID	empirical	16169070
APLP1	SETDB1	MINT	empirical	15383276

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 1

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 27

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 74

A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Crystal structure of the E2 domain of amyloid precursor protein-like protein 1 in complex with sucrose octasulfate.
Xue Y, Lee S, Wang Y, Ha Y
J Biol Chem. 2011
PubMed ID: 21715329
The E2 domains of APP and APLP1 share a conserved mode of dimerization.
Lee S, Xue Y, Hu J, Wang Y, Liu X, Demeler B, Ha Y
Biochemistry. 2011
PubMed ID: 21574595
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Expression of prion gene and presence of prion protein during development of mouse molar tooth germ.
Khan QE, Press CM, Sehic A, Landin MA, Risnes S, Osmundsen H
Eur J Oral Sci. 2010
PubMed ID: 21083616
Enrichment of glycopeptides for glycan structure and attachment site identification.
Nilsson J, Rüetschi U, Halim A, Hesse C, Carlsohn E, Brinkmalm G, Larson G
Nat Methods. 2009
PubMed ID: 19838169
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.
Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H
J Neurosci. 2009
PubMed ID: 19726636
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M
EMBO Mol Med. 2009
PubMed ID: 20049724
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.
Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM
Brain Res. 2009
PubMed ID: 19401174
Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.
Kaden D, Voigt P, Munter LM, Bobowski KD, Schaefer M, Multhaup G
J Cell Sci. 2009
PubMed ID: 19126676
Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract.
Arvidsson Y, Andersson E, Bergström A, Andersson MK, Altiparmak G, Illerskog AC, Ahlman H, Lamazhapova D, Nilsson O
Endocr Relat Cancer. 2008
PubMed ID: 18430897
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system.
Osterfield M, Egelund R, Young LM, Flanagan JG
Development. 2008
PubMed ID: 18272596
The in vivo brain interactome of the amyloid precursor protein.
Bai Y, Markham K, Chen F, Weerasekera R, Watts J, Horne P, Wakutani Y, Bagshaw R, Mathews PM, Fraser PE, Westaway D, St George-Hyslop P, Schmitt-Ulms G
Mol Cell Proteomics. 2008
PubMed ID: 17934213
Characterization of the adaptor protein ARH expression in the brain and ARH molecular interactions.
Mameza MG, Lockard JM, Zamora E, Hillefors M, Lavina ZS, Kaplan BB
J Neurochem. 2007
PubMed ID: 17727637
Changes in gene-expression during development of the murine molar tooth germ.
Osmundsen H, Landin MA, From SH, Kolltveit KM, Risnes S
Arch Oral Biol. 2007
PubMed ID: 17374359
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.
Wang B, Yang L, Wang Z, Zheng H
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17709753
Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference.
Sakai T, Hohjoh H
Cell Biol Int. 2006
PubMed ID: 16889988
Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase.
Weber B, Schaper C, Scholz J, Bein B, Rodde C, H Tonner P
Cell Signal. 2006
PubMed ID: 16531006
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein.
Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF
J Biol Chem. 2006
PubMed ID: 16344553
Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.
Cao Q, Huang YS, Kan MC, Richter JD
Mol Cell Biol. 2005
PubMed ID: 16314516
Homo- and heterodimerization of APP family members promotes intercellular adhesion.
Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K
EMBO J. 2005
PubMed ID: 16193067
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein.
López-Sánchez N, Müller U, Frade JM
Neuroscience. 2005
PubMed ID: 15561424
Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.
Frederikse PH, Yun E, Kao HT, Zigler JS, Sun Q, Qazi AS
Mol Vis. 2004
PubMed ID: 15529118
Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.
Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Müller U
EMBO J. 2004
PubMed ID: 15385965
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK
FASEB J. 2004
PubMed ID: 15208260
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA
Nat Biotechnol. 2004
PubMed ID: 15146195
The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation.
Eggert S, Paliga K, Soba P, Evin G, Masters CL, Weidemann A, Beyreuther K
J Biol Chem. 2004
PubMed ID: 14970212
The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature. 2004
PubMed ID: 15057824
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.
Li Q, Südhof TC
J Biol Chem. 2004
PubMed ID: 14699153
Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.
Ho A, Südhof TC
Proc Natl Acad Sci U S A. 2004
PubMed ID: 14983046
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.
Yamakami M, Yoshimori T, Yokosawa H
J Biol Chem. 2003
PubMed ID: 14563850
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.
Adlerz L, Beckman M, Holback S, Tehranian R, Cortés Toro V, Iverfeldt K
Brain Res Mol Brain Res. 2003
PubMed ID: 14597230
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ
Biochemistry. 2003
PubMed ID: 12779321
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription.
Scheinfeld MH, Ghersi E, Laky K, Fowlkes BJ, D'Adamio L
J Biol Chem. 2002
PubMed ID: 12228233
Evidence for a copper-binding superfamily of the amyloid precursor protein.
Simons A, Ruppert T, Schmidt C, Schlicksupp A, Pipkorn R, Reed J, Masters CL, White AR, Cappai R, Beyreuther K, Bayer TA, Multhaup G
Biochemistry. 2002
PubMed ID: 12135352
Disabled-1 interacts with a novel developmentally regulated protocadherin.
Homayouni R, Rice DS, Curran T
Biochem Biophys Res Commun. 2001
PubMed ID: 11716507
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.
Morris SM, Cooper JA
Traffic. 2001
PubMed ID: 11247302
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
Heber S, Herms J, Gajic V, Hainfellner J, Aguzzi A, Rülicke T, von Kretzschmar H, von Koch C, Sisodia S, Tremml P, Lipp HP, Wolfer DP, Müller U
J Neurosci. 2000
PubMed ID: 11050115
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
It all sticks together--the APP-related family of proteins and Alzheimer's disease.
Bayer TA, Cappai R, Masters CL, Beyreuther K, Multhaup G
Mol Psychiatry. 1999
PubMed ID: 10578233
Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
Homayouni R, Rice DS, Sheldon M, Curran T
J Neurosci. 1999
PubMed ID: 10460257
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.
Tanahashi H, Tabira T
Neurosci Lett. 1999
PubMed ID: 10081969
Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T
J Biol Chem. 1999
PubMed ID: 9890987
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
McNamara MJ, Ruff CT, Wasco W, Tanzi RE, Thinakaran G, Hyman BT
Brain Res. 1998
PubMed ID: 9729270
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
Duilio A, Faraonio R, Minopoli G, Zambrano N, Russo T
Biochem J. 1998
PubMed ID: 9461550
Structure of the human amyloid-precursor-like protein gene APLP1 at 19q13.1.
Lenkkeri U, Kestilä M, Lamerdin J, McCready P, Adamson A, Olsen A, Tryggvason K
Hum Genet. 1998
PubMed ID: 9521588
Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.
Paliga K, Peraus G, Kreger S, Dürrwang U, Hesse L, Multhaup G, Masters CL, Beyreuther K, Weidemann A
Eur J Biochem. 1997
PubMed ID: 9428684
Identification of candidate proteins binding to prion protein.
Yehiely F, Bamborough P, Da Costa M, Perry BJ, Thinakaran G, Cohen FE, Carlson GA, Prusiner SB
Neurobiol Dis. 1997
PubMed ID: 9173930
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM
Hum Mol Genet. 1996
PubMed ID: 8894693
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Characterization of the genomic structure of the mouse APLP1 gene.
Zhong S, Wu K, Black IB, Schaar DG
Genomics. 1996
PubMed ID: 8786110
Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I.
Beher D, Hesse L, Masters CL, Multhaup G
J Biol Chem. 1996
PubMed ID: 8576160
Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.
Lee NH, Weinstock KG, Kirkness EF, Earle-Hughes JA, Fuldner RA, Marmaros S, Glodek A, Gocayne JD, Adams MD, Kerlavage AR
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7667285
Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density.
Kim TW, Wu K, Xu JL, McAuliffe G, Tanzi RE, Wasco W, Black IB
Brain Res Mol Brain Res. 1995
PubMed ID: 7494461
Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase,
Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H
Neuroscience. 1995
PubMed ID: 7542371
CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse.
Blangy A, Vidal F, Cuzin F, Yang YH, Boulukos K, Rassoulzadegan M
J Cell Sci. 1995
PubMed ID: 7539437
The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily.
Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W
J Biol Chem. 1994
PubMed ID: 7929392
The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome 19.
Wasco W, Brook JD, Tanzi RE
Genomics. 1993
PubMed ID: 8432545
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.
Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1279693

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	333	11803	502317
EnsEMBL Gene(s)	ENSG00000105290	ENSMUSG00000006651	ENSRNOG00000020851
Unigene	Hs.74565	Mm.2381	Rn.114169
Homologene	APLP1	Aplp1	Aplp1
OMIM	104775	N/A	N/A
GeneCards	APLP1	N/A	N/A
Beta Cell Genomics	DT.100802232 DT.100823207 DT.101966404 DT.447930	DT.532055 DT.94201377	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000221891	N/A	N/A
WikiGenes	333	11803	502317

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