HSPD1

Summary Top Help

Gene Description:

heat shock protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin)

Synonyms:

HuCHA60, HSPD1, SPG13, CPN60, HSP65, Hspd1, Hsp60, Hspd1-30p, 60kDa, HSP-60, GROEL, HSP60, HLD4

Orthologs:

Human HSPD1 (protein-coding), Mouse Hspd1 (protein-coding), Rat Hspd1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr2:198351305..198381461 (30.16 kb) View in Genome Browser

(Mouse) NCBIM37 - chr1:55134678..55145087 (10.41 kb) View in Genome Browser

(Rat) RGSC3.4 - chr9:53884193..53895043 (10.85 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for HSPD1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for HSPD1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 3

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 51

Nucleotide binding	GO:0000166
Lipopolysaccharide binding	GO:0001530
P53 binding	GO:0002039
B cell cytokine production	GO:0002368
MyD88-dependent toll-like receptor signaling pathway	GO:0002755
Positive regulation of T cell mediated immune response to tumor cell	GO:0002842
DNA replication origin binding	GO:0003688
Single-stranded DNA binding	GO:0003697
Protein binding	GO:0005515
ATP binding	GO:0005524
Extracellular space	GO:0005615
Cytoplasm	GO:0005737
Mitochondrion	GO:0005739
Mitochondrial inner membrane	GO:0005743
Mitochondrial matrix	GO:0005759
Early endosome	GO:0005769
Cytosol	GO:0005829
Coated pit	GO:0005905
ATP catabolic process	GO:0006200
'de novo' protein folding	GO:0006458
Activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919
Response to unfolded protein	GO:0006986
Cell death	GO:0008219
Cell surface	GO:0009986
ATPase activity	GO:0016887
Cyclin-dependent protein kinase activating kinase holoenzyme complex	GO:0019907
Coated vesicle	GO:0030135
Secretory granule	GO:0030141
Positive regulation of interferon-alpha production	GO:0032727
Positive regulation of interferon-gamma production	GO:0032729
Positive regulation of interleukin-10 production	GO:0032733
Positive regulation of interleukin-12 production	GO:0032735
Positive regulation of interleukin-6 production	GO:0032755
Protein refolding	GO:0042026
B cell proliferation	GO:0042100
T cell activation	GO:0042110
B cell activation	GO:0042113
Positive regulation of macrophage activation	GO:0043032
Positive regulation of apoptotic process	GO:0043065
Negative regulation of apoptotic process	GO:0043066
Cell surface binding	GO:0043498
Interspecies interaction between organisms	GO:0044419
Plasma membrane part	GO:0044459
Lipopolysaccharide receptor complex	GO:0046696
Isotype switching to IgG isotypes	GO:0048291
Protein stabilization	GO:0050821
Positive regulation of T cell activation	GO:0050870
Unfolded protein binding	GO:0051082
Chaperone binding	GO:0051087
Chaperone-mediated protein complex assembly	GO:0051131
Protein maturation	GO:0051604

Publications from PubMed Top Help

Type 1 Diabetes Publications: 13

Differential protein expression in pancreatic islets after treatment with an imidazoline compound.
Jägerbrink T, Lexander H, Palmberg C, Shafqat J, Sharoyko V, Berggren PO, Efendic S, Zaitsev S, Jörnvall H
Cell Mol Life Sci. 2007
PubMed ID: 17458497
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L
Cell. 2006
PubMed ID: 16959573
Transgenic overproduction of murine 60 kDa heat shock protein in the liver does not prevent type I diabetes in NOD mice.
Lüth S, Lohse AW, Herkel J
Diabetologia. 2006
PubMed ID: 16547598
Heat shock protein 60 modified with O-linked N-acetylglucosamine is involved in pancreatic beta-cell death under hyperglycemic conditions.
Kim HS, Kim EM, Lee J, Yang WH, Park TY, Kim YM, Cho JW
FEBS Lett. 2006
PubMed ID: 16579988
Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry.
Ahmed M, Forsberg J, Bergsten P
J Proteome Res. 2005
PubMed ID: 15952740
DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes.
Quintana FJ, Carmi P, Cohen IR
J Immunol. 2002
PubMed ID: 12421990
Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis.
Jensen P, Johansen HK, Carmi P, Høiby N, Cohen IR
J Autoimmun. 2001
PubMed ID: 11591125
Colocalization of chaperone Cpn60, proinsulin and convertase PC1 within immature secretory granules of insulin-secreting cells suggests a role for Cpn60 in insulin processing.
Arias AE, Vélez-Granell CS, Mayer G, Bendayan M
J Cell Sci. 2000
PubMed ID: 10806118
Expression of the human heat shock protein 60 in thyroid, pancreatic, hepatic and adrenal autoimmunity.
Mallard K, Jones DB, Richmond J, McGill M, Foulis AK
J Autoimmun. 1996
PubMed ID: 8845058
A family of hsp60-related proteins in pancreatic beta cells of non-obese diabetic (NOD) mice.
Brudzynski K, Cunningham IA, Martinez V
J Autoimmun. 1995
PubMed ID: 8824711
Immunocytochemical localization of heat-shock protein 60-related protein in beta-cell secretory granules and its altered distribution in non-obese diabetic mice.
Brudzynski K, Martinez V, Gupta RS
Diabetologia. 1992
PubMed ID: 1516759
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.
Elias D, Reshef T, Birk OS, van der Zee R, Walker MD, Cohen IR
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1707531
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
Elias D, Markovits D, Reshef T, van der Zee R, Cohen IR
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2406723

Publications: 327

Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism.
Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA
Biochem Biophys Res Commun. 2011
PubMed ID: 22079093
Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs).
Lopitz-Otsoa F, Rodriguez-Suarez E, Aillet F, Casado-Vela J, Lang V, Matthiesen R, Elortza F, Rodriguez MS
J Proteomics. 2011
PubMed ID: 22178446
Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR
J Biol Chem. 2011
PubMed ID: 21987572
The first identification of lysine malonylation substrates and its regulatory enzyme.
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y
Mol Cell Proteomics. 2011
PubMed ID: 21908771
Murine Sirt3 protein isoforms have variable half-lives.
Yang Y, Chen KY, Tong Q
Gene. 2011
PubMed ID: 21840382
Heat shock protein-60 expression was significantly correlated with the prognosis of lung adenocarcinoma.
Xu X, Wang W, Shao W, Yin W, Chen H, Qiu Y, Mo M, Zhao J, Deng Q, He J
J Surg Oncol. 2011
PubMed ID: 21671464
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W
J Biol Chem. 2011
PubMed ID: 21775438
Molecular chaperones as a common set of proteins that regulate the invasion phenotype of head and neck cancer.
Chiu CC, Lin CY, Lee LY, Chen YJ, Lu YC, Wang HM, Liao CT, Chang JT, Cheng AJ
Clin Cancer Res. 2011
PubMed ID: 21642380
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S
Mol Cell. 2011
PubMed ID: 21726808
Hsp60 and heme oxygenase-1 (Hsp32) in acute myocardial infarction.
Novo G, Cappello F, Rizzo M, Fazio G, Zambuto S, Tortorici E, Gammazza AM, Corrao S, Zummo G, De Macario EC, Macario AJ, Assennato P, Novo S, Li Volti G, Volti GL
Transl Res. 2011
PubMed ID: 21497776
Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis.
Goh YC, Yap CT, Huang BH, Cronshaw AD, Leung BP, Lai PB, Hart SP, Dransfield I, Ross JA
Cell Mol Life Sci. 2011
PubMed ID: 20953657
Characterization of potential S-nitrosylation sites in the myocardium.
Kohr MJ, Aponte AM, Sun J, Wang G, Murphy E, Gucek M, Steenbergen C
Am J Physiol Heart Circ Physiol. 2011
PubMed ID: 21278135
Agglutination of Histoplasma capsulatum by IgG monoclonal antibodies against Hsp60 impacts macrophage effector functions.
Guimarães AJ, Frases S, Pontes B, de Cerqueira MD, Rodrigues ML, Viana NB, Nimrichter L, Nosanchuk JD
Infect Immun. 2011
PubMed ID: 21134968
Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.
Greco TM, Yu F, Guise AJ, Cristea IM
Mol Cell Proteomics. 2011
PubMed ID: 21081666
Heat-shock protein expression in leukemia.
Sedlackova L, Spacek M, Holler E, Imryskova Z, Hromadnikova I
Tumour Biol. 2011
PubMed ID: 20694586
A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression.
Dogukan A, Tuzcu M, Agca CA, Gencoglu H, Sahin N, Onderci M, Ozercan IH, Ilhan N, Kucuk O, Sahin K
Nutr Cancer. 2011
PubMed ID: 21391123
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells.
Jha R, Vardhan H, Bas S, Salhan S, Mittal A
Inflamm Res. 2011
PubMed ID: 20686813
Human hepatoma cell line (HepG2) cellular response to hypothermic stress with recovery. Induction of Hsp70, Hsp60 and Hsf1 expression.
Rada A, Merentes E, Rodríguez M, Anselmi G, Strauss M
Invest Clin. 2010
PubMed ID: 21361146
Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells.
Ghosh JC, Siegelin MD, Dohi T, Altieri DC
Cancer Res. 2010
PubMed ID: 20978188
Inactivation of the hereditary spastic paraplegia-associated Hspd1 gene encoding the Hsp60 chaperone results in early embryonic lethality in mice.
Christensen JH, Nielsen MN, Hansen J, Füchtbauer A, Füchtbauer EM, West M, Corydon TJ, Gregersen N, Bross P
Cell Stress Chaperones. 2010
PubMed ID: 20393889
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer.
Castilla C, Congregado B, Conde JM, Medina R, Torrubia FJ, Japón MA, Sáez C
Urology. 2010
PubMed ID: 20708221
Immunization with a combination of ApoB and HSP60 epitopes significantly reduces early atherosclerotic lesion in Apobtm2SgyLdlrtm1Her/J mice.
Lu X, Chen D, Endresz V, Xia M, Faludi I, Burian K, Szabo A, Csanadi A, Miczak A, Gonczol E, Kakkar V
Atherosclerosis. 2010
PubMed ID: 20609438
Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway.
Xie J, Zhu H, Guo L, Ruan Y, Wang L, Sun L, Zhou L, Wu W, Yun X, Shen A, Gu J
J Immunol. 2010
PubMed ID: 20631313
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR
Nat Biotechnol. 2010
PubMed ID: 20639865
Expression and purification of secreted recombinant hsp60 from eukaryotic cells.
Zhou L, Xie J, Ruan Y, Zhu H, Wang W, Yun X, Guo L, Gan H, Sun L, Yu M, Gu J
Protein Expr Purif. 2010
PubMed ID: 20362058
Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.
Martins-de-Souza D, Maccarrone G, Wobrock T, Zerr I, Gormanns P, Reckow S, Falkai P, Schmitt A, Turck CW
J Psychiatr Res. 2010
PubMed ID: 20471030
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.
Richter R, Rorbach J, Pajak A, Smith PM, Wessels HJ, Huynen MA, Smeitink JA, Lightowlers RN, Chrzanowska-Lightowlers ZM
EMBO J. 2010
PubMed ID: 20186120
Quantitative proteome analysis of multidrug resistance in human ovarian cancer cell line.
Li SL, Ye F, Cai WJ, Hu HD, Hu P, Ren H, Zhu FF, Zhang DZ
J Cell Biochem. 2010
PubMed ID: 20082317
Regulation of heat shock protein 60 and 72 expression in the failing heart.
Wang Y, Chen L, Hagiwara N, Knowlton AA
J Mol Cell Cardiol. 2010
PubMed ID: 19945465
Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways.
Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C
Hum Immunol. 2010
PubMed ID: 19913588
Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PLoS One. 2010
PubMed ID: 20877624
Assessment of heat shock protein (HSP60, HSP72, HSP90, and HSC70) expression in cultured limbal stem cells following air lifting.
Ebrahimi M, Mohammadi P, Daryadel A, Baharvand H
Mol Vis. 2010
PubMed ID: 20806039
Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation.
Chun JN, Choi B, Lee KW, Lee DJ, Kang DH, Lee JY, Song IS, Kim HI, Lee SH, Kim HS, Lee NK, Lee SY, Lee KJ, Kim J, Kang SW
PLoS One. 2010
PubMed ID: 20351780
Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes.
Mukherjee K, Conway de Macario E, Macario AJ, Brocchieri L
BMC Evol Biol. 2010
PubMed ID: 20193073
Hsp60 is actively secreted by human tumor cells.
Merendino AM, Bucchieri F, Campanella C, Marcianò V, Ribbene A, David S, Zummo G, Burgio G, Corona DF, Conway de Macario E, Macario AJ, Cappello F
PLoS One. 2010
PubMed ID: 20169074
Extracellular heat shock protein 60, cardiac myocytes, and apoptosis.
Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA
Circ Res. 2009
PubMed ID: 19875724
Regulation of HSP60 and the role of MK2 in a new model of severe experimental pancreatitis.
Li YY, Ochs S, Gao ZR, Malo A, Chen CJ, Lv S, Gallmeier E, Göke B, Schäfer C
Am J Physiol Gastrointest Liver Physiol. 2009
PubMed ID: 20501446
Identification of novel spartin-interactors shows spartin is a multifunctional protein.
Milewska M, McRedmond J, Byrne PC
J Neurochem. 2009
PubMed ID: 19765186
The MitCHAP-60 disease is due to entropic destabilization of the human mitochondrial Hsp60 oligomer.
Parnas A, Nadler M, Nisemblat S, Horovitz A, Mandel H, Azem A
J Biol Chem. 2009
PubMed ID: 19706612
Heat shock protein 60 causes osteoclastic bone resorption via toll-like receptor-2 in estrogen deficiency.
Koh JM, Lee YS, Kim YS, Park SH, Lee SH, Kim HH, Lee MS, Lee KU, Kim GS
Bone. 2009
PubMed ID: 19527807
Heat shock proteins in children and young adults on chronic hemodialysis.
Musiał K, Szprynger K, Szczepańska M, Zwolińska D
Pediatr Nephrol. 2009
PubMed ID: 19475432
Sequence variants in SPAST, SPG3A and HSPD1 in hereditary spastic paraplegia.
Svenstrup K, Bross P, Koefoed P, Hjermind LE, Eiberg H, Born AP, Vissing J, Gyllenborg J, Nørremølle A, Hasholt L, Nielsen JE
J Neurol Sci. 2009
PubMed ID: 19423133
Heat shock protein 60: evidence for receptor-mediated induction of proinflammatory mediators during adipocyte differentiation.
Gülden E, Märker T, Kriebel J, Kolb-Bachofen V, Burkart V, Habich C
FEBS Lett. 2009
PubMed ID: 19647739
Circulating anti-heat-shock-protein antibodies in normal pregnancy and preeclampsia.
Molvarec A, Derzsy Z, Kocsis J, Boze T, Nagy B, Balogh K, Makó V, Cervenak L, Mézes M, Karádi I, Prohászka Z, Rigó J
Cell Stress Chaperones. 2009
PubMed ID: 19205928
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Is heat shock protein 60 associated with type 2 diabetes mellitus?
Imatoh T, Sugie T, Miyazaki M, Tanihara S, Baba M, Momose Y, Uryu Y, Une H
Diabetes Res Clin Pract. 2009
PubMed ID: 19576649
Heat shock protein 60 (HSP60) stimulates neutrophil effector functions.
Osterloh A, Geisinger F, Piédavent M, Fleischer B, Brattig N, Breloer M
J Leukoc Biol. 2009
PubMed ID: 19447897
Mitochondrial heat shock protein (HSP) 70 synergizes with HSP60 in transducing endothelial cell apoptosis induced by anti-HSP60 autoantibody.
Alard JE, Dueymes M, Mageed RA, Saraux A, Youinou P, Jamin C
FASEB J. 2009
PubMed ID: 19346294
Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced.
Cohen-Sfady M, Pevsner-Fischer M, Margalit R, Cohen IR
J Immunol. 2009
PubMed ID: 19561102
Interaction of hepatitis C virus core protein with Hsp60 triggers the production of reactive oxygen species and enhances TNF-alpha-mediated apoptosis.
Kang SM, Kim SJ, Kim JH, Lee W, Kim GW, Lee KH, Choi KY, Oh JW
Cancer Lett. 2009
PubMed ID: 19264393
[Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis]
Gao Y, Guo ZP
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19764566
Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis.
de Jong H, Lafeber FF, de Jager W, Haverkamp MH, Kuis W, Bijlsma JW, Prakken BJ, Albani S
Arthritis Rheum. 2009
PubMed ID: 19565483
Myocardial heat shock protein 60 expression is upregulated following acute cardiac rejection.
Sarri S, Shaw SM, Gieschen-Krische MA, Archer L, Yonan N, Fildes JE
Transpl Immunol. 2009
PubMed ID: 19386281
Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors.
Kim YS, Koh JM, Lee YS, Kim BJ, Lee SH, Lee KU, Kim GS
Bone. 2009
PubMed ID: 19306954
Expression of heat shock protein 60 kDa is upregulated in cervical cancer.
Hwang YJ, Lee SP, Kim SY, Choi YH, Kim MJ, Lee CH, Lee JY, Kim DY
Yonsei Med J. 2009
PubMed ID: 19568603
Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.
Drenos F, Talmud PJ, Casas JP, Smeeth L, Palmen J, Humphries SE, Hingorani AD
Hum Mol Genet. 2009
PubMed ID: 19336475
[Expressions of heat shock protein (HSP) family HSP 60, 70 and 90alpha in colorectal cancer tissues and their correlations to pathohistological characteristics].
Zhang WL, Gao XQ, Han JX, Wang GQ, Yue LT
Ai Zheng. 2009
PubMed ID: 19635199
Interaction between HSP60 and beta-catenin promotes metastasis.
Tsai YP, Yang MH, Huang CH, Chang SY, Chen PM, Liu CJ, Teng SC, Wu KJ
Carcinogenesis. 2009
PubMed ID: 19369584
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y
Proteomics. 2009
PubMed ID: 19343720
Mitochondrial DNA variability modulates mRNA and intra-mitochondrial protein levels of HSP60 and HSP75: experimental evidence from cybrid lines.
Bellizzi D, Taverna D, D'Aquila P, De Blasi S, De Benedictis G
Cell Stress Chaperones. 2009
PubMed ID: 18815895
Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis.
Dieudé M, Gillis MA, Théorêt JF, Thorin E, Lajoie G, Levine JS, Merhi Y, Rauch J
J Thromb Haemost. 2009
PubMed ID: 19192108
Alteration of Cpn60 expression in pancreatic tissue of rats with acute pancreatitis.
Li XL, Li K, Li YY, Feng Y, Gong Q, Li YN, Li XJ, Chen CJ
Cell Stress Chaperones. 2009
PubMed ID: 18766470
A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response.
Campanella C, Marino Gammazza A, Mularoni L, Cappello F, Zummo G, Di Felice V
Int J Immunogenet. 2009
PubMed ID: 19207939
Myocardial heat shock protein 60 expression in insulin-resistant and diabetic rats.
Chen HS, Wu TE, Juan CC, Lin HD
J Endocrinol. 2009
PubMed ID: 18948349
Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.
Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh SS, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner K
J Biol Chem. 2009
PubMed ID: 19004824
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK
Sci Signal. 2009
PubMed ID: 19690332
RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication.
Padwad YS, Mishra KP, Jain M, Chanda S, Karan D, Ganju L
Immunobiology. 2009
PubMed ID: 19261350
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
Glatter T, Wepf A, Aebersold R, Gstaiger M
Mol Syst Biol. 2009
PubMed ID: 19156129
Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Maccarrone G, Hunyadi-Gulyás E, Eberlin MN, Souza GH, Marangoni S, Novello JC, Turck CW, Dias-Neto E
J Psychiatr Res. 2008
PubMed ID: 19110265
Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese.
Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, Pockley AG, Hu FB, Wu T
Circulation. 2008
PubMed ID: 19106391
Direct regulation of HSP60 expression by c-MYC induces transformation.
Tsai YP, Teng SC, Wu KJ
FEBS Lett. 2008
PubMed ID: 19022255
The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and women.
Ellins E, Shamaei-Tousi A, Steptoe A, Donald A, O'Meagher S, Halcox J, Henderson B
J Hypertens. 2008
PubMed ID: 19008717
cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.
Russo A, Cirulli C, Amoresano A, Pucci P, Pietropaolo C, Russo G
Biochim Biophys Acta. 2008
PubMed ID: 18790094
Chaperonin chamber accelerates protein folding through passive action of preventing aggregation.
Apetri AC, Horwich AL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18987317
Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell arteritis patients.
López-Hoyos M, Alvarez L, Ruiz Soto M, Blanco R, José Bartolomé M, Martínez-Taboada VM
Clin Exp Rheumatol. 2008
PubMed ID: 19210880
Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells.
Qiu J, Gao HQ, Liang Y, Yu H, Zhou RH
Biochim Biophys Acta. 2008
PubMed ID: 18692161
Heat shock proteins 27, 60 and 70 as prognostic markers of prostate cancer.
Glaessgen A, Jonmarker S, Lindberg A, Nilsson B, Lewensohn R, Ekman P, Valdman A, Egevad L
APMIS. 2008
PubMed ID: 19132982
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells.
Campanella C, Bucchieri F, Ardizzone NM, Marino Gammazza A, Montalbano A, Ribbene A, Di Felice V, Bellafiore M, David S, Rappa F, Marasà M, Peri G, Farina F, Czarnecka AM, Conway de Macario E, Macario AJ, Zummo G, Cappello F
Eur J Histochem. 2008
PubMed ID: 19109096
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Heat shock protein 60 induces inflammatory mediators in mouse adipocytes.
Gülden E, Mollérus S, Brüggemann J, Burkart V, Habich C
FEBS Lett. 2008
PubMed ID: 18619964
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
A mitochondrial protein compendium elucidates complex I disease biology.
Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK
Cell. 2008
PubMed ID: 18614015
Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.
Magen D, Georgopoulos C, Bross P, Ang D, Segev Y, Goldsher D, Nemirovski A, Shahar E, Ravid S, Luder A, Heno B, Gershoni-Baruch R, Skorecki K, Mandel H
Am J Hum Genet. 2008
PubMed ID: 18571143
The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.
Bross P, Naundrup S, Hansen J, Nielsen MN, Christensen JH, Kruhøffer M, Palmfeldt J, Corydon TJ, Gregersen N, Ang D, Georgopoulos C, Nielsen KL
J Biol Chem. 2008
PubMed ID: 18400758
Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry.
Forsman A, Rüetschi U, Ekholm J, Rymo L
J Proteome Res. 2008
PubMed ID: 18457437
Differential effect of oxidative stress on the apoptosis of early and late passage human diploid fibroblasts: implication of heat shock protein 60.
Lee YH, Lee JC, Moon HJ, Jung JE, Sharma M, Park BH, Yi HK, Jhee EC
Cell Biochem Funct. 2008
PubMed ID: 18399535
Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse.
Walsh A, Whelan D, Bielanowicz A, Skinner B, Aitken RJ, O'Bryan MK, Nixon B
Biol Reprod. 2008
PubMed ID: 18276932
Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells.
Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Di Leva G, Fabbri M, Birk DE, Raso C, Green-Church K, Spagnoli LG, Venuta S, Huebner K, Croce CM
J Biol Chem. 2008
PubMed ID: 18319262
HSP60 is a rare cause of hereditary spastic paraparesis, but may act as a genetic modifier.
Hewamadduma CA, Kirby J, Kershaw C, Martindale J, Dalton A, McDermott CJ, Shaw PJ
Neurology. 2008
PubMed ID: 18458233
A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.
Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, Nitsch R, Weber JR
J Neurosci. 2008
PubMed ID: 18322079
Genetic variation in heat shock protein 60 gene and coronary heart disease in China: tagging-SNP haplotype analysis in a case-control study.
He MA, Zhang X, Wang J, Cheng L, Zhou L, Zeng H, Wang F, Chen Y, Xu Z, Wei Q, Hu FB, Wu T
Cell Stress Chaperones. 2008
PubMed ID: 18320357
Hsp60-mediated T cell stimulation is independent of TLR4 and IL-12.
Osterloh A, Veit A, Gessner A, Fleischer B, Breloer M
Int Immunol. 2008
PubMed ID: 18256040
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Hsp60 regulation of tumor cell apoptosis.
Ghosh JC, Dohi T, Kang BH, Altieri DC
J Biol Chem. 2008
PubMed ID: 18086682
Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositis.
Elst EF, Klein M, de Jager W, Kamphuis S, Wedderburn LR, van der Zee R, Albani S, Kuis W, Prakken BJ
Arthritis Rheum. 2008
PubMed ID: 18240224
HSP60 as a target of anti-ergotypic regulatory T cells.
Quintana FJ, Mimran A, Carmi P, Mor F, Cohen IR
PLoS ONE. 2008
PubMed ID: 19107191
T-cell reactivity against HSP60 relates to early but not advanced atherosclerosis.
Knoflach M, Kiechl S, Mayrl B, Kind M, Gaston JS, van der Zee R, Faggionato A, Mayr A, Willeit J, Wick G
Atherosclerosis. 2007
PubMed ID: 17070529
Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3.
Chandra D, Choy G, Tang DG
J Biol Chem. 2007
PubMed ID: 17823127
HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis.
Lin L, Kim SC, Wang Y, Gupta S, Davis B, Simon SI, Torre-Amione G, Knowlton AA
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17675567
Expression of Hsp60 and Grp78 in the human endometrium and oviduct, and their effect on sperm functions.
Lachance C, Bailey JL, Leclerc P
Hum Reprod. 2007
PubMed ID: 17670764
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.
DeLuca GC, Ramagopalan SV, Cader MZ, Dyment DA, Herrera BM, Orton S, Degenhardt A, Pugliatti M, Sadovnick AD, Sotgiu S, Ebers GC
J Neurol. 2007
PubMed ID: 17420921
Diverse regulatory activity of human heat shock proteins 60 and 70 on endotoxin-induced inflammation.
Bangen JM, Schade FU, Flohé SB
Biochem Biophys Res Commun. 2007
PubMed ID: 17553457
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.
Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL
Cell Metab. 2007
PubMed ID: 17681147
Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.
Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D
Genesis. 2007
PubMed ID: 17661394
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.
Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B
Mol Cell. 2007
PubMed ID: 17643375
A novel mutation in the HSPD1 gene in a patient with hereditary spastic paraplegia.
Hansen J, Svenstrup K, Ang D, Nielsen MN, Christensen JH, Gregersen N, Nielsen JE, Georgopoulos C, Bross P
J Neurol. 2007
PubMed ID: 17420924
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
Sablina AA, Chen W, Arroyo JD, Corral L, Hector M, Bulmer SE, DeCaprio JA, Hahn WC
Cell. 2007
PubMed ID: 17540176
HSP60 trafficking in adult cardiac myocytes: role of the exosomal pathway.
Gupta S, Knowlton AA
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17307989
Plasminogen and angiostatin interact with heat shock proteins.
Dudani AK, Mehic J, Martyres A
Mol Cell Biochem. 2007
PubMed ID: 17206383
Altered distribution of heat shock protein 60 (Hsp60) with dysregulated expression of DHX32.
Chen Y, Alli Z, Ackerley C, Al-Saud B, Abdelhaleem M
Exp Mol Pathol. 2007
PubMed ID: 17174952
Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock.
Wheeler DS, Lahni P, Odoms K, Jacobs BR, Carcillo JA, Doughty LA, Wong HR
Inflamm Res. 2007
PubMed ID: 17588138
Subcellular stress response after traumatic brain injury.
Truettner JS, Hu B, Alonso OF, Bramlett HM, Kokame K, Dietrich WD
J Neurotrauma. 2007
PubMed ID: 17439344
CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.
Kumar P, Ambasta RK, Veereshwarayya V, Rosen KM, Kosik KS, Band H, Mestril R, Patterson C, Querfurth HW
Hum Mol Genet. 2007
PubMed ID: 17317785
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.
Oksala NK, Lappalainen J, Laaksonen DE, Khanna S, Kaarniranta K, Sen CK, Atalay M
Antioxid Redox Signal. 2007
PubMed ID: 17280490
Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide.
Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M
J Biol Chem. 2007
PubMed ID: 17164250
Heat shock protein 60 or 70 activates nitric-oxide synthase (NOS) I- and inhibits NOS II-associated signaling and depresses the mitochondrial apoptotic cascade during brain stem death.
Chan JY, Cheng HL, Chou JL, Li FC, Dai KY, Chan SH, Chang AY
J Biol Chem. 2007
PubMed ID: 17150954
Protective effect of human heat shock protein 60 suggested by its association with decreased seropositivity to pathogens.
Steptoe A, Shamaei-Tousi A, Gylfe A, Bailey L, Bergström S, Coates AR, Henderson B
Clin Vaccine Immunol. 2007
PubMed ID: 17202307
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
Koch HB, Zhang R, Verdoodt B, Bailey A, Zhang CD, Yates JR, Menssen A, Hermeking H
Cell Cycle. 2007
PubMed ID: 17314511
Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors.
Shamaei-Tousi A, Steptoe A, O'Donnell K, Palmen J, Stephens JW, Hurel SJ, Marmot M, Homer K, D'Aiuto F, Coates AR, Humphries SE, Henderson B
Cell Stress Chaperones. 2007
PubMed ID: 18229457
HSPD1 is not a major susceptibility gene for rheumatoid arthritis in the French Caucasian population.
Jacq L, Teixeira VH, Garnier S, Michou L, Dieudé P, Rocha D, Pierlot C, Lemaire I, Quillet P, Hilliquin P, Mbarek H, Petit-Teixeira E, Cornélis F
J Hum Genet. 2007
PubMed ID: 17925998
Circulating heat shock proteins and inflammatory markers in patients with idiopathic left ventricular dysfunction: their relationships with myocardial and microvascular impairment.
Giannessi D, Colotti C, Maltinti M, Del Ry S, Prontera C, Turchi S, Labbate A, Neglia D
Cell Stress Chaperones. 2007
PubMed ID: 17915559
Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry.
Dai J, Jin WH, Sheng QH, Shieh CH, Wu JR, Zeng R
J Proteome Res. 2007
PubMed ID: 17203969
Changes in Hsp60 level of the failing heart following acute myocardial infarction and the effect of long-term treatment with trandolapril.
Toga W, Tanonaka K, Takeo S
Biol Pharm Bull. 2007
PubMed ID: 17202668
Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.
Bross P, Li Z, Hansen J, Hansen JJ, Nielsen MN, Corydon TJ, Georgopoulos C, Ang D, Lundemose JB, Niezen-Koning K, Eiberg H, Yang H, Kølvraa S, Bolund L, Gregersen N
J Hum Genet. 2007
PubMed ID: 17072495
Identification of immunodominant CD4+ T cell epitopes in patients with Yersinia-induced reactive arthritis by cytometric cytokine secretion assay.
Thiel A, Wu P, Lanowska M, Dong J, Radbruch A, Sieper J
Arthritis Rheum. 2006
PubMed ID: 17075864
Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis.
Veereshwarayya V, Kumar P, Rosen KM, Mestril R, Querfurth HW
J Biol Chem. 2006
PubMed ID: 16887805
Generation of HSP60-specific regulatory T cell and effect on atherosclerosis.
Yang K, Li D, Luo M, Hu Y
Cell Immunol. 2006
PubMed ID: 17324390
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP
Nat Biotechnol. 2006
PubMed ID: 16964243
Proteomic comparison of prostate cancer cell lines LNCaP-FGC and LNCaP-r reveals heatshock protein 60 as a marker for prostate malignancy.
Johansson B, Pourian MR, Chuan YC, Byman I, Bergh A, Pang ST, Norstedt G, Bergman T, Pousette A
Prostate. 2006
PubMed ID: 16705742
[Polymorphisms of hsp 60 gene in Chinese Han people]
Wang J, Yang XB, Bai Y, Jiang Q, He YF, Chen YW, He MA, Wu TC
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006
PubMed ID: 16978514
Heat shock protein 60 in rostral ventrolateral medulla reduces cardiovascular fatality during endotoxaemia in the rat.
Chang AY, Chan JY, Chou JL, Li FC, Dai KY, Chan SH
J Physiol. 2006
PubMed ID: 16675490
Heat shock protein 60 enhances CD4+ CD25+ regulatory T cell function via innate TLR2 signaling.
Zanin-Zhorov A, Cahalon L, Tal G, Margalit R, Lider O, Cohen IR
J Clin Invest. 2006
PubMed ID: 16767222
Proteomic analysis of altered protein expression in skeletal muscle of rats in a hypermetabolic state induced by burn sepsis.
Duan X, Berthiaume F, Yarmush D, Yarmush ML
Biochem J. 2006
PubMed ID: 16483253
Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4.
de Graaf R, Kloppenburg G, Kitslaar PJ, Bruggeman CA, Stassen F
Microbes Infect. 2006
PubMed ID: 16843693
Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells.
Chen W, Wang J, Shao C, Liu S, Yu Y, Wang Q, Cao X
Eur J Immunol. 2006
PubMed ID: 16708399
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Binding specificity of Toll-like receptor cytoplasmic domains.
Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S
Eur J Immunol. 2006
PubMed ID: 16482509
Elucidation of ATP-stimulated stress protein expression of RBA-2 type-2 astrocytes: ATP potentiate HSP60 and Cu/Zn SOD expression and stimulates pI shift of peroxiredoxin II.
Chen HB, Chan YT, Hung AC, Tsai YC, Sun SH
J Cell Biochem. 2006
PubMed ID: 16178011
Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins.
Yu HP, Shimizu T, Choudhry MA, Hsieh YC, Suzuki T, Bland KI, Chaudry IH
J Mol Cell Cardiol. 2006
PubMed ID: 16288780
Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
McCracken S, Longman D, Marcon E, Moens P, Downey M, Nickerson JA, Jessberger R, Wilde A, Caceres JF, Emili A, Blencowe BJ
J Biol Chem. 2005
PubMed ID: 16159877
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY
Biochem Biophys Res Commun. 2005
PubMed ID: 16236267
Induction of endothelial cell apoptosis by the binding of anti-endothelial cell antibodies to Hsp60 in vasculitis-associated systemic autoimmune diseases.
Jamin C, Dugué C, Alard JE, Jousse S, Saraux A, Guillevin L, Piette JC, Youinou P
Arthritis Rheum. 2005
PubMed ID: 16320351
Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study.
Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S, Xu Q
Stroke. 2005
PubMed ID: 16254226
Proteomic analysis of ubiquitinated proteins from human MCF-7 breast cancer cells by immunoaffinity purification and mass spectrometry.
Vasilescu J, Smith JC, Ethier M, Figeys D
J Proteome Res. 2005
PubMed ID: 16335966
Large-scale analysis of the human ubiquitin-related proteome.
Matsumoto M, Hatakeyama S, Oyamada K, Oda Y, Nishimura T, Nakayama KI
Proteomics. 2005
PubMed ID: 16196087
Identification and characterization of molecular interactions between mortalin/mtHsp70 and HSP60.
Wadhwa R, Takano S, Kaur K, Aida S, Yaguchi T, Kaul Z, Hirano T, Taira K, Kaul SC
Biochem J. 2005
PubMed ID: 15957980
The 14-3-3 protein forms a molecular complex with heat shock protein Hsp60 and cellular prion protein.
Satoh J, Onoue H, Arima K, Yamamura T
J Neuropathol Exp Neurol. 2005
PubMed ID: 16215457
Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis.
Bruneel A, Labas V, Mailloux A, Sharma S, Royer N, Vinh J, Pernet P, Vaubourdolle M, Baudin B
Proteomics. 2005
PubMed ID: 16130169
Identification of immunodominant autoantigens in rat autoimmune orchitis.
Fijak M, Iosub R, Schneider E, Linder M, Respondek K, Klug J, Meinhardt A
J Pathol. 2005
PubMed ID: 16092147
Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway.
Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, Lider O, Cohen IR
J Immunol. 2005
PubMed ID: 16148103
Induction of heat shock proteins by hyperglycemic cerebral ischemia.
Muranyi M, He QP, Fong KS, Li PA
Brain Res Mol Brain Res. 2005
PubMed ID: 15961182
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Anti-heat shock protein 60 autoantibodies induce atherosclerosis in apolipoprotein E-deficient mice via endothelial damage.
Foteinos G, Afzal AR, Mandal K, Jahangiri M, Xu Q
Circulation. 2005
PubMed ID: 16116071
Differential expression of stress response genes in the H-Tx rat model of congenital hydrocephalus.
Morgan FW, Stewart JA, Smith AN, Tarnuzzer RW
Brain Res Mol Brain Res. 2005
PubMed ID: 15964663
Association of heat shock proteins and neuronal membrane components with lipid rafts from the rat brain.
Chen S, Bawa D, Besshoh S, Gurd JW, Brown IR
J Neurosci Res. 2005
PubMed ID: 15948182
Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats.
Zhou J, Ando H, Macova M, Dou J, Saavedra JM
J Cereb Blood Flow Metab. 2005
PubMed ID: 15729290
Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques.
Benagiano M, D'Elios MM, Amedei A, Azzurri A, van der Zee R, Ciervo A, Rombolà G, Romagnani S, Cassone A, Del Prete G
J Immunol. 2005
PubMed ID: 15879154
Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy.
Pfister G, Stroh CM, Perschinka H, Kind M, Knoflach M, Hinterdorfer P, Wick G
J Cell Sci. 2005
PubMed ID: 15784682
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
Nature. 2005
PubMed ID: 15815621
Decreased testicular expression of cAMP response element modulator (CREM) in rat with varicocele.
Yu JJ, Xu YM
Arch Androl. 2005
PubMed ID: 15804863
Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production.
Johnson BJ, Le TT, Dobbin CA, Banovic T, Howard CB, Flores Fde M, Vanags D, Naylor DJ, Hill GR, Suhrbier A
J Biol Chem. 2005
PubMed ID: 15546885
Heat shock protein 60: specific binding of lipopolysaccharide.
Habich C, Kempe K, van der Zee R, Rümenapf R, Akiyama H, Kolb H, Burkart V
J Immunol. 2005
PubMed ID: 15661886
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase.
Cappello F, David S, Rappa F, Bucchieri F, Marasà L, Bartolotta TE, Farina F, Zummo G
BMC Cancer. 2005
PubMed ID: 16253146
HIV-1 integration: an interplay between HIV-1 integrase, cellular and viral proteins.
Van Maele B, Debyser Z
AIDS Rev. 2005
PubMed ID: 15875659
Proteomic identification of proteins specifically oxidized by intracerebral injection of amyloid beta-peptide (1-42) into rat brain: implications for Alzheimer's disease.
Boyd-Kimball D, Sultana R, Poon HF, Lynn BC, Casamenti F, Pepeu G, Klein JB, Butterfield DA
Neuroscience. 2005
PubMed ID: 15802185
Molecular chaperone, HSP60, and cytochrome P450 2E1 co-expression in dilated cardiomyopathy.
Sidorik L, Kyyamova R, Bobyk V, Kapustian L, Rozhko O, Vigontina O, Ryabenko D, Danko I, Maksymchuk O, Kovalenko VN, Filonenko VV, Chaschin NA
Cell Biol Int. 2005
PubMed ID: 15763499
Insulin deficiency downregulated heat shock protein 60 and IGF-1 receptor signaling in diabetic myocardium.
Chen HS, Shan YX, Yang TL, Lin HD, Chen JW, Lin SJ, Wang PH
Diabetes. 2005
PubMed ID: 15616026
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.
Karki RG, Tang Y, Burke TR, Nicklaus MC
J Comput Aided Mol Des. 2004
PubMed ID: 16075307
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Lipopolysaccharide-free heat shock protein 60 activates T cells.
Osterloh A, Meier-Stiegen F, Veit A, Fleischer B, von Bonin A, Breloer M
J Biol Chem. 2004
PubMed ID: 15371451
Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein.
Quintana FJ, Carmi P, Mor F, Cohen IR
Arthritis Rheum. 2004
PubMed ID: 15529360
Association of anti-heat shock protein 65 antibodies with development of postoperative atrial fibrillation.
Mandal K, Jahangiri M, Mukhin M, Poloniecki J, Camm AJ, Xu Q
Circulation. 2004
PubMed ID: 15249499
Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV
Biochem J. 2004
PubMed ID: 15242332
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Identifying the molecular phenotype of renal progenitor cells.
Challen GA, Martinez G, Davis MJ, Taylor DF, Crowe M, Teasdale RD, Grimmond SM, Little MH
J Am Soc Nephrol. 2004
PubMed ID: 15339983
Methylprednisolone-induced expression of mitochondrial heat shock protein 60 protects mitochondrial membrane potential in the hypoxic rat liver.
Motoyama S, Saito S, Itoh H, Minamiya Y, Maruyama K, Okuyama M, Ogawa J
Shock. 2004
PubMed ID: 15316393
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T
Curr Biol. 2004
PubMed ID: 15324660
Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction.
Reverter-Branchat G, Cabiscol E, Tamarit J, Ros J
J Biol Chem. 2004
PubMed ID: 15166233
Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition.
Asquith KL, Baleato RM, McLaughlin EA, Nixon B, Aitken RJ
J Cell Sci. 2004
PubMed ID: 15252132
HSP10 selective preference for myeloid and megakaryocytic precursors in normal human bone marrow.
Cappello F, Tripodo C, Farina F, Franco V, Zummo G
Eur J Histochem. 2004
PubMed ID: 15590416
Identification of the heat shock protein 60 epitope involved in receptor binding on macrophages.
Habich C, Kempe K, Burkart V, Van Der Zee R, Lillicrap M, Gaston H, Kolb H
FEBS Lett. 2004
PubMed ID: 15196922
Perioperative kinetics of heat shock protein 60 in serum during orthotopic liver transplantation.
Faybik P, Wachauer D, Hetz H, Bachleitner T, Steltzer H, Schett G, Krenn CG
Transplant Proc. 2004
PubMed ID: 15251360
Interaction of the hepatitis B virus X protein (HBx) with heat shock protein 60 enhances HBx-mediated apoptosis.
Tanaka Y, Kanai F, Kawakami T, Tateishi K, Ijichi H, Kawabe T, Arakawa Y, Kawakami T, Nishimura T, Shirakata Y, Koike K, Omata M
Biochem Biophys Res Commun. 2004
PubMed ID: 15120623
Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.
Zhu Y, Swanson BJ, Wang M, Hildeman DA, Schaefer BC, Liu X, Suzuki H, Mihara K, Kappler J, Marrack P
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15136728
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS
Oncogene. 2004
PubMed ID: 14968112
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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Nature. 2004
PubMed ID: 15057822
Analysis of proteins copurifying with the CD4/lck complex using one-dimensional polyacrylamide gel electrophoresis and mass spectrometry: comparison with affinity-tag based protein detection and evaluation of different solubilization methods.
Bernhard OK, Cunningham AL, Sheil MM
J Am Soc Mass Spectrom. 2004
PubMed ID: 15047060
Intragraft heat shock protein-60 expression after small bowel transplantation in the mouse.
Oltean M, Dindelegan G, Kurlberg G, Nilsson O, Karlsson-Parra A, Olausson M
Transplant Proc. 2004
PubMed ID: 15050156
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: implications on decreased myocardial protection in diabetic cardiomyopathy.
Shan YX, Yang TL, Mestril R, Wang PH
J Biol Chem. 2003
PubMed ID: 12970367
Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer.
Paavonen J, Karunakaran KP, Noguchi Y, Anttila T, Bloigu A, Dillner J, Hallmans G, Hakulinen T, Jellum E, Koskela P, Lehtinen M, Thoresen S, Lam H, Shen C, Brunham RC
Am J Obstet Gynecol. 2003
PubMed ID: 14634555
Similar effects of cocaine and immobilization stress on the levels of heat-shock proteins and stress-activated protein kinases in the rat hippocampus, and on swimming behaviors: the contribution of dopamine and benzodiazepine receptors.
Hayase T, Yamamoto Y, Yamamoto K, Muso E, Shiota K, Hayashi T
Behav Pharmacol. 2003
PubMed ID: 14557723
Proteomic analysis of the mouse liver mitochondrial inner membrane.
Da Cruz S, Xenarios I, Langridge J, Vilbois F, Parone PA, Martinou JC
J Biol Chem. 2003
PubMed ID: 12865426
Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication.
Park SG, Lee SM, Jung G
J Biol Chem. 2003
PubMed ID: 12869561
DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide.
Quintana FJ, Carmi P, Mor F, Cohen IR
J Immunol. 2003
PubMed ID: 14500649
Hsp10 and Hsp60 modulate Bcl-2 family and mitochondria apoptosis signaling induced by doxorubicin in cardiac muscle cells.
Shan YX, Liu TJ, Su HF, Samsamshariat A, Mestril R, Wang PH
J Mol Cell Cardiol. 2003
PubMed ID: 12967636
Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma.
Lebret T, Watson RW, Molinié V, O'Neill A, Gabriel C, Fitzpatrick JM, Botto H
Cancer. 2003
PubMed ID: 12942564
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ
Nature. 2003
PubMed ID: 12931191
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Hansen J, Floss T, Van Sloun P, Füchtbauer EM, Vauti F, Arnold HH, Schnütgen F, Wurst W, von Melchner H, Ruiz P
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12904583
Increased seroreactivity in tic disorder patients to a 60 kDa protein band from a neuronal cell line.
Hoekstra PJ, Horst G, Limburg PC, Troost PW, van Lang N, de Bildt A, Korf J, Kallenberg CG, Minderaa RB
J Neuroimmunol. 2003
PubMed ID: 12965262
Antibodies to human heat shock protein 60, hypertension and dyslipidemia. A study of joint effects on coronary risk.
Kervinen H, Huittinen T, Vaarala O, Leinonen M, Saikku P, Manninen V, Mänttäri M
Atherosclerosis. 2003
PubMed ID: 12921987
Expression levels of hsc70 and hsp60 are developmentally regulated during B-cell maturation and not associated to childhood c-ALL at presentation or relapse.
Wehner PS, Nielsen B, Hokland M
Eur J Haematol. 2003
PubMed ID: 12890148
Proteomic analysis of rat heart in ischemia and ischemia-reperfusion using fluorescence two-dimensional difference gel electrophoresis.
Sakai J, Ishikawa H, Kojima S, Satoh H, Yamamoto S, Kanaoka M
Proteomics. 2003
PubMed ID: 12872233
Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor alpha from murine macrophages.
Gao B, Tsan MF
J Biol Chem. 2003
PubMed ID: 12686536
Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production.
Pignatelli D, Ferreira J, Soares P, Costa MJ, Magalhães MC
Microsc Res Tech. 2003
PubMed ID: 12768547
Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria.
Chandra D, Tang DG
J Biol Chem. 2003
PubMed ID: 12611882
Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis.
Wang G, Zhang J, Moskophidis D, Mivechi NF
Genesis. 2003
PubMed ID: 12748967
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J
Nat Biotechnol. 2003
PubMed ID: 12665801
Heat shock protein 60 expression in patients undergoing cardiac operations.
Schäfler AE, Kirmanoglou K, Gallmeier U, Pecher P, Hannekum A, Schumacher B
J Cardiovasc Surg (Torino). 2003
PubMed ID: 12813381
Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype.
Flohé SB, Brüggemann J, Lendemans S, Nikulina M, Meierhoff G, Flohé S, Kolb H
J Immunol. 2003
PubMed ID: 12594256
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function.
Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM
J Biol Chem. 2003
PubMed ID: 12493773
Different heat shock protein 60 species share pro-inflammatory activity but not binding sites on macrophages.
Habich C, Kempe K, van der Zee R, Burkart V, Kolb H
FEBS Lett. 2003
PubMed ID: 12505167
Heat shock proteins expression in brain stem after subarachnoid hemorrhage in rats.
Satoh M, Tang J, Nanda A, Zhang JH
Acta Neurochir Suppl. 2003
PubMed ID: 14753490
Hsp70 is present in human saliva.
Fábián TK, Gáspár J, Fejérdy L, Kaán B, Bálint M, Csermely P, Fejérdy P
Med Sci Monit. 2003
PubMed ID: 12552239
Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter.
Hansen JJ, Bross P, Westergaard M, Nielsen MN, Eiberg H, Børglum AD, Mogensen J, Kristiansen K, Bolund L, Gregersen N
Hum Genet. 2003
PubMed ID: 12483302
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
Michaëlsson J, Teixeira de Matos C, Achour A, Lanier LL, Kärre K, Söderström K
J Exp Med. 2002
PubMed ID: 12461076
Deficiency of chaperonin 60 in Down's syndrome.
Bozner P, Wilson GL, Druzhyna NM, Bryant-Thomas TK, LeDoux SP, Wilson GL, Pappolla MA
J Alzheimers Dis. 2002
PubMed ID: 12515899
Immunohistochemical analysis of inducible nitric oxide synthase (iNOS) and heat shock proteins (HSPs) in ameloblastomas.
Kumamoto H, Suzuki T, Ooya K
J Oral Pathol Med. 2002
PubMed ID: 12406306
Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli.
Lee KH, Kim HS, Jeong HS, Lee YS
Biochem Biophys Res Commun. 2002
PubMed ID: 12387818
Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway.
Lee SM, Li ML, Tse YC, Leung SC, Lee MM, Tsui SK, Fung KP, Lee CY, Waye MM
Life Sci. 2002
PubMed ID: 12215374
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R
EMBO J. 2002
PubMed ID: 12234937
Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60.
Quintana FJ, Carmi P, Mor F, Cohen IR
J Immunol. 2002
PubMed ID: 12218165
Circulating heat shock protein and heat shock protein antibody levels in established hypertension.
Pockley AG, De Faire U, Kiessling R, Lemne C, Thulin T, Frostegård J
J Hypertens. 2002
PubMed ID: 12195124
Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress.
Lewthwaite J, Owen N, Coates A, Henderson B, Steptoe A
Circulation. 2002
PubMed ID: 12105158
Cytosolic heat shock protein 60, apoptosis, and myocardial injury.
Kirchhoff SR, Gupta S, Knowlton AA
Circulation. 2002
PubMed ID: 12070120
Complement activating antibodies against the human 60 kDa heat shock protein as a new independent family risk factor of coronary heart disease.
Veres A, Szamosi T, Ablonczy M, Szamosi T, Singh M, Karádi I, Romics L, Füst G, Prohászka Z
Eur J Clin Invest. 2002
PubMed ID: 12059985
Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.
Gurer C, Cimarelli A, Luban J
J Virol. 2002
PubMed ID: 11932435
Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.
Hansen JJ, Dürr A, Cournu-Rebeix I, Georgopoulos C, Ang D, Nielsen MN, Davoine CS, Brice A, Fontaine B, Gregersen N, Bross P
Am J Hum Genet. 2002
PubMed ID: 11898127
Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70.
Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM
J Biol Chem. 2002
PubMed ID: 11777905
Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation.
Barazi HO, Zhou L, Templeton NS, Krutzsch HC, Roberts DD
Cancer Res. 2002
PubMed ID: 11888933
The promoter polymorphism of the IL-6 gene is associated with levels of antibodies to 60-kDa heat-shock proteins.
Veres A, Prohászka Z, Kilpinen S, Singh M, Füst G, Hurme M
Immunogenetics. 2002
PubMed ID: 11862386
Heat shock proteins 70 and 60 share common receptors which are expressed on human monocyte-derived but not epidermal dendritic cells.
Lipsker D, Ziylan U, Spehner D, Proamer F, Bausinger H, Jeannin P, Salamero J, Bohbot A, Cazenave JP, Drillien R, Delneste Y, Hanau D, de la Salle H
Eur J Immunol. 2002
PubMed ID: 11807771
Directed proteomic analysis of the human nucleolus.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI
Curr Biol. 2002
PubMed ID: 11790298
Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.
Parissi V, Calmels C, De Soultrait VR, Caumont A, Fournier M, Chaignepain S, Litvak S
J Virol. 2001
PubMed ID: 11689615
H9724, a monoclonal antibody to Borrelia burgdorferi's flagellin, binds to heat shock protein 60 (HSP60) within live neuroblastoma cells: a potential role for HSP60 in peptide hormone signaling and in an autoimmune pathogenesis of the neuropathy of Lyme d
Sigal LH, Williams S, Soltys B, Gupta R
Cell Mol Neurobiol. 2001
PubMed ID: 11860186
A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH.
Sandrock B, Egly JM
J Biol Chem. 2001
PubMed ID: 11445587
Thermodynamics of the folding of D-glyceraldehyde-3-phosphate dehydrogenase assisted by protein disulfide isomerase studied by microcalorimetry.
Liang Y, Li J, Chen J, Wang CC
Eur J Biochem. 2001
PubMed ID: 11488911
Heat shock proteins as "danger signals": eukaryotic Hsp60 enhances and accelerates antigen-specific IFN-gamma production in T cells.
Breloer M, Dorner B, Moré SH, Roderian T, Fleischer B, von Bonin A
Eur J Immunol. 2001
PubMed ID: 11449358
Identification and characterization of the potential promoter regions of 1031 kinds of human genes.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S
Genome Res. 2001
PubMed ID: 11337467
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES, Cohen GM
EMBO J. 2001
PubMed ID: 11230124
Antibodies to human heat-shock protein 60 are associated with the presence and severity of coronary artery disease: evidence for an autoimmune component of atherogenesis.
Zhu J, Quyyumi AA, Rott D, Csako G, Wu H, Halcox J, Epstein SE
Circulation. 2001
PubMed ID: 11222468
The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.
Richardson A, Schwager F, Landry SJ, Georgopoulos C
J Biol Chem. 2001
PubMed ID: 11050098
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Changes in skeletal muscle heat shock proteins: pathological significance.
Liu Y, Steinacker JM
Front Biosci. 2001
PubMed ID: 11145923
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Induction and membrane expression of heat shock proteins in heat-treated HPC-4 cells is correlated with increased resistance to LAK-mediated lysis.
Vendetti S, Cicconi R, Piselli P, Vismara D, Cassol M, Delpino A
J Exp Clin Cancer Res. 2000
PubMed ID: 11144526
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Protein substrate binding induces conformational changes in the chaperonin GroEL. A suggested mechanism for unfoldase activity.
Hammarström P, Persson M, Owenius R, Lindgren M, Carlsson U
J Biol Chem. 2000
PubMed ID: 10811634
Stress proteins and the immune response.
Moseley P
Immunopharmacology. 2000
PubMed ID: 10960671
Identification and characterization of a cDNA clone encoding the heat shock protein (Hsp60) from the biting midge, Culicoides variipennis sonorensis Wirth and Jones.
Abdallah MA, Pollenz RS, Nunamaker RA, Murphy KE
Biochem Genet. 2000
PubMed ID: 11091906
HSP expression in human leukocytes is modulated by endurance exercise.
Fehrenbach E, Passek F, Niess AM, Pohla H, Weinstock C, Dickhuth HH, Northoff H
Med Sci Sports Exerc. 2000
PubMed ID: 10731000
A new locus for autosomal dominant pure spastic paraplegia, on chromosome 2q24-q34.
Fontaine B, Davoine CS, Dürr A, Paternotte C, Feki I, Weissenbach J, Hazan J, Brice A
Am J Hum Genet. 2000
PubMed ID: 10677329
gammadelta T cells lyse autologous and allogenic oesophageal tumours: involvement of heat-shock proteins in the tumour cell lysis.
Thomas ML, Samant UC, Deshpande RK, Chiplunkar SV
Cancer Immunol Immunother. 2000
PubMed ID: 10663613
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex.
Ohashi K, Burkart V, Flohé S, Kolb H
J Immunol. 2000
PubMed ID: 10623794
Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease.
Schäfer C, Williams JA
J Gastroenterol. 2000
PubMed ID: 10632533
Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins.
Hittelman AB, Burakov D, Iñiguez-Lluhí JA, Freedman LP, Garabedian MJ
EMBO J. 1999
PubMed ID: 10508170
A 60 kD heat-shock protein-like molecule interacts with the HIV transmembrane glycoprotein gp41.
Speth C, Prohászka Z, Mair M, Stöckl G, Zhu X, Jöbstl B, Füst G, Dierich MP
Mol Immunol. 1999
PubMed ID: 10499815
Overexpression of the human 72 kDa heat shock protein in renal tubular cells confers resistance against oxidative injury and cisplatin toxicity.
Komatsuda A, Wakui H, Oyama Y, Imai H, Miura AB, Itoh H, Tashima Y
Nephrol Dial Transplant. 1999
PubMed ID: 10382997
Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.
Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, Tawa P, Ruel R, Rosen A, Nicholson DW
EMBO J. 1999
PubMed ID: 10205159
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells.
Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S
EMBO J. 1999
PubMed ID: 10205158
The expression of heat shock protein 60 in patients with dilated cardiomyopathy.
Latif N, Taylor PM, Khan MA, Yacoub MH, Dunn MJ
Basic Res Cardiol. 1999
PubMed ID: 10326659
Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral circulation of normal individuals.
Pockley AG, Bulmer J, Hanks BM, Wright BH
Cell Stress Chaperones. 1999
PubMed ID: 10467106
EPR mapping of interactions between spin-labeled variants of human carbonic anhydrase II and GroEL: evidence for increased flexibility of the hydrophobic core by the interaction.
Persson M, Hammarström P, Lindgren M, Jonsson BH, Svensson M, Carlsson U
Biochemistry. 1999
PubMed ID: 9890926
Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.
Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A
J Biol Chem. 1999
PubMed ID: 9867803
Heat shock proteins and heat shock protein-antibody complexes in placental tissues.
Ziegert M, Witkin SS, Sziller I, Alexander H, Brylla E, Härtig W
Infect Dis Obstet Gynecol. 1999
PubMed ID: 10449265
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: relation to microbial flora, vaginal pH, and method of contraception.
Giraldo P, Neuer A, Ribeiro-Filho A, Linhares I, Witkin SS
Infect Dis Obstet Gynecol. 1999
PubMed ID: 10231004
Heat shock proteins in human endometrium throughout the menstrual cycle.
Tabibzadeh S, Broome J
Infect Dis Obstet Gynecol. 1999
PubMed ID: 10231001
Mitochondrial stress protein recognition of inactivated dehydrogenases during mammalian cell death.
Bruschi SA, Lindsay JG, Crabb JW
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9811814
Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane.
Khan IU, Wallin R, Gupta RS, Kammer GM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9724719
Clonidine-Induced Heat-Shock Protein Expression in Rat Aorta.
Moen RJ, La Voi KP, Zhang M, Blake MJ
J Cardiovasc Pharmacol Ther. 1998
PubMed ID: 10684495
Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines.
Abu-Hadid M, Wilkes JD, Elakawi Z, Pendyala L, Perez RP
Cancer Lett. 1997
PubMed ID: 18372523
The genes encoding mammalian chaperonin 60 and chaperonin 10 are linked head-to-head and share a bidirectional promoter.
Ryan MT, Herd SM, Sberna G, Samuel MM, Hoogenraad NJ, Høj PB
Gene. 1997
PubMed ID: 9322735
Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells.
Soltys BJ, Gupta RS
Cell Biol Int. 1997
PubMed ID: 9243807
Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10.
Yi Y, Yang X, Brunham RC
Infect Immun. 1997
PubMed ID: 9125545
A two-dimensional gel database of human colon carcinoma proteins.
Ji H, Reid GE, Moritz RL, Eddes JS, Burgess AW, Simpson RJ
Electrophoresis. 1997
PubMed ID: 9150948
Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.
Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS
Electrophoresis. 1997
PubMed ID: 9150946
Macrophage-lysis mediated by autoantibodies to heat shock protein 65/60.
Schett G, Metzler B, Mayr M, Amberger A, Niederwieser D, Gupta RS, Mizzen L, Xu Q, Wick G
Atherosclerosis. 1997
PubMed ID: 9051195
Significant hydrogen exchange protection in GroEL-bound DHFR is maintained during iterative rounds of substrate cycling.
Gross M, Robinson CV, Mayhew M, Hartl FU, Radford SE
Protein Sci. 1996
PubMed ID: 8976559
Prion protein PrPc interacts with molecular chaperones of the Hsp60 family.
Edenhofer F, Rieger R, Famulok M, Wendler W, Weiss S, Winnacker EL
J Virol. 1996
PubMed ID: 8676499
Possible association of chaperonin 60 with secretory proteins in pancreatic acinar cells.
Le Gall IM, Bendayan M
J Histochem Cytochem. 1996
PubMed ID: 8675995
Induction of heat shock protein in monocytic cells by oxidized low density lipoprotein.
Frostegård J, Kjellman B, Gidlund M, Andersson B, Jindal S, Kiessling R
Atherosclerosis. 1996
PubMed ID: 8678928
Heat shock proteins in human endometrium throughout the menstrual cycle.
Tabibzadeh S, Kong QF, Satyaswaroop PG, Babaknia A
Hum Reprod. 1996
PubMed ID: 8671282
Protein folding in the central cavity of the GroEL-GroES chaperonin complex.
Mayhew M, da Silva AC, Martin J, Erdjument-Bromage H, Tempst P, Hartl FU
Nature. 1996
PubMed ID: 8559246
Common antigenicity between Yersinia enterocolitica-derived heat-shock protein and the retina, and its role in uveitis.
Tanaka T, Yamakawa N, Yamaguchi H, Okada AA, Konoeda Y, Ogawa T, Kamiya S, Usui M
Ophthalmic Res. 1996
PubMed ID: 8979276
[Immunostaining of mitochondrial heat shock proteins (mtHSPs) in skeletal muscle fibers of mitochondrial cytopathy]
Ibi T, Sahashi K, Ling J, Marui K, Mitsuma T
Rinsho Shinkeigaku. 1996
PubMed ID: 8689794
Coexpression of heat-shock protein 60 and intercellular-adhesion molecule-1 is related to increased adhesion of monocytes and T cells to aortic endothelium of rats in response to endotoxin.
Seitz CS, Kleindienst R, Xu Q, Wick G
Lab Invest. 1996
PubMed ID: 8569188
Expression of mammalian 60-kD heat shock protein in the joints of mice with pristane-induced arthritis.
Barker RN, Wells AD, Ghoraishian M, Easterfield AJ, Hitsumoto Y, Elson CJ, Thompson SJ
Clin Exp Immunol. 1996
PubMed ID: 8565293
Messenger RNA expression of heat shock proteins (HSPs) during ocular development.
Tanaka Y, Kobayashi K, Kita M, Kinoshita S, Imanishi J
Curr Eye Res. 1995
PubMed ID: 8974842
Expression of mitochondrial heat shock protein 60 in distinct cell types and defined stages of rat seminiferous epithelium.
Meinhardt A, Parvinen M, Bacher M, Aumüller G, Hakovirta H, Yagi A, Seitz J
Biol Reprod. 1995
PubMed ID: 7780001
Presence of Chromatium vinosum chaperonins 10 and 60 in mitochondria and peroxisomes of rat hepatocytes.
Vélez-Granell CS, Arias AE, Torres-Ruíz JA, Bendayan M
Biol Cell. 1995
PubMed ID: 8882520
Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells.
Xu Q, Schett G, Seitz CS, Hu Y, Gupta RS, Wick G
Circ Res. 1994
PubMed ID: 7525102
The human myocardial two-dimensional gel protein database: update 1994.
Corbett JM, Wheeler CH, Baker CS, Yacoub MH, Dunn MJ
Electrophoresis. 1994
PubMed ID: 7895732
Separation and sequencing of familiar and novel murine proteins using preparative two-dimensional gel electrophoresis.
Merrick BA, Patterson RM, Witcher LL, He C, Selkirk JK
Electrophoresis. 1994
PubMed ID: 7523108
Molecular chaperones in pancreatic tissue: the presence of cpn10, cpn60 and hsp70 in distinct compartments along the secretory pathway of the acinar cells.
Vélez-Granell CS, Arias AE, Torres-Ruíz JA, Bendayan M
J Cell Sci. 1994
PubMed ID: 7911805
Intestinal expression and cellular immune responses to human heat-shock protein 60 in Crohn's disease.
Baca-Estrada ME, Gupta RS, Stead RH, Croitoru K
Dig Dis Sci. 1994
PubMed ID: 7907543
Immuno-gold electron microscopical detection of heat shock protein 60 (hsp60) in mitochondria of rat hepatocytes and myocardiocytes.
Kreisel W, Hildebrandt H, Schiltz E, Köhler G, Spamer C, Dietz C, Mössner W, Heilmann C
Acta Histochem. 1994
PubMed ID: 7518175
Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence.
Ryan MT, Hoogenraad NJ, Høj PB
FEBS Lett. 1994
PubMed ID: 7904573
The complete primary structure of rat chaperonin 10 reveals a putative beta alpha beta nucleotide-binding domain with homology to p21ras.
Hartman DJ, Hoogenraad NJ, Condron R, Høj PB
Biochim Biophys Acta. 1993
PubMed ID: 8101099
Human liver protein map: a reference database established by microsequencing and gel comparison.
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R
Electrophoresis. 1992
PubMed ID: 1286669
Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin.
Dawson SJ, White LA
J Infect. 1992
PubMed ID: 1602151
Identification of a mammalian 10-kDa heat shock protein, a mitochondrial chaperonin 10 homologue essential for assisted folding of trimeric ornithine transcarbamoylase in vitro.
Hartman DJ, Hoogenraad NJ, Condron R, Høj PB
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1348860
An interaction between p21ras and heat shock protein hsp60, a chaperonin.
Ikawa S, Weinberg RA
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1347942
Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides.
Nagata K, Ide Y, Takagi T, Ohtani K, Aoshima M, Tozawa H, Nakamura M, Sugamura K
J Virol. 1992
PubMed ID: 1731090
Nucleotide and deduced amino acid sequence of a murine cDNA clone encoding one member of the hsp65 multigene family.
Lotscher E, Allison JP
Nucleic Acids Res. 1990
PubMed ID: 2263486
cDNA and deduced amino acid sequence of rat liver prehsp60 (chaperonin-60).
Peralta D, Hartman DJ, McIntosh AM, Hoogenraad NJ, Høj PB
Nucleic Acids Res. 1990
PubMed ID: 1979858
Nucleotide sequence of mouse HSP60 (chaperonin, GroEL homolog) cDNA.
Venner TJ, Gupta RS
Biochim Biophys Acta. 1990
PubMed ID: 1979012
Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis.
Ward LD, Hong J, Whitehead RH, Simpson RJ
Electrophoresis. 1990
PubMed ID: 2079031
Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families.
Venner TJ, Singh B, Gupta RS
DNA Cell Biol. 1990
PubMed ID: 1980192
Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA.
Venner TJ, Gupta RS
Nucleic Acids Res. 1990
PubMed ID: 1976241
Mitochondrial import of the human chaperonin (HSP60) protein.
Singh B, Patel HV, Ridley RG, Freeman KB, Gupta RS
Biochem Biophys Res Commun. 1990
PubMed ID: 1972619
Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.
Jindal S, Dudani AK, Singh B, Harley CB, Gupta RS
Mol Cell Biol. 1989
PubMed ID: 2568584
Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein).
Waldinger D, Eckerskorn C, Lottspeich F, Cleve H
Biol Chem Hoppe Seyler. 1988
PubMed ID: 2907406

Model Organism Phenotype Links from MGI Top Help

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	Human	Mouse	Rat
Entrez Gene	3329	15510	63868
EnsEMBL Gene(s)	ENSG00000144381	ENSMUSG00000025980	ENSRNOG00000014525
Unigene	Hs.595053	Mm.1777	Rn.102058
Homologene	HSPD1	Hspd1	Hspd1
OMIM	118190	N/A	N/A
GeneCards	HSPD1	N/A	N/A
Beta Cell Genomics	DT.100059914 DT.100892472 DT.100892482 DT.100892498 DT.101986431 DT.92433271 DT.95221973 DT.95256762	DT.102552211 DT.102553326 DT.110921961 DT.110922198 DT.91404265 DT.94376348 DT.99869689	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000340019	N/A	N/A
WikiGenes	3329	15510	63868

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Interactor	Interactor	Sources	Classification	Pubmed IDs
HSPD1	HDAC5	BioGRID	empirical	21081666
HSPD1	CDK9	BioGRID	empirical	17643375
HSPD1	STUB1	BioGRID	empirical	17317785
HSPD1	CFTR	IntAct	empirical	17110338
HSPD1	GABARAP	IntAct	empirical	20562859
HSPD1	GABARAPL2	IntAct	empirical	20562859
HSPD1	CRKL	IntAct	empirical	20697350
HSPD1	DHFR	HPRD	empirical	8976559 8559246
HSPD1	DLG4	IntAct	empirical	19455133
HSPD1	EEF2	Sanger Interaction Map	predicted	15345047
HSPD1	EGFR	IntAct	empirical	15657067
HSPD1	ESR1	IntAct	empirical	21182205
HSPD1	ALDH2	HPRD, BioGRID	empirical	12387818
HSPD1	MED19	IntAct	empirical	15175163
HSPD1	FDXR	IntAct	empirical	18319262
HSPD1	FHIT	HPRD, IntAct	empirical	19004824 18319262
HSPD1	SPG20	IntAct, BioGRID	empirical	19765186
HSPD1	KIAA0664	Sanger Interaction Map	predicted	15345047
HSPD1	SIRT3	IntAct, BioGRID	empirical	19343720 21840382
HSPD1	SIRT1	IntAct, BioGRID	empirical	19343720
HSPD1	SRRM2	BioGRID	empirical	16159877
HSPD1	GABARAPL1	IntAct	empirical	20562859
HSPD1	ALK	BioGRID	empirical	14968112
HSPD1	RPAP1	BioGRID	empirical	17643375
HSPD1	NPHP4	IntAct	empirical	21565611
HSPD1	AMFR	BioGRID	empirical	17681147
HSPD1	GRB2	IntAct	empirical	12577067
HSPD1	NR3C1	BioGRID	empirical	10508170
HSPD1	HDAC1	BioGRID	empirical	11777905
HSPD1	HNRNPH1	BioGRID	empirical	17643375
HSPD1	HNRNPK	IntAct	empirical	16518874
HSPD1	HSPA5	IntAct	empirical	18064632
HSPD1	HSPD1	HPRD	empirical	11488911
HSPD1	HSPE1	HPRD, IntAct, BioGRID	empirical	11050098 10205158 12387818 19004824 18319262
HSPD1	ICT1	BioGRID	empirical	20186120
HSPD1	APP	BioGRID	empirical	17317785
HSPD1	ITGA3	HPRD	empirical	11888933
HSPD1	KCNMA1	IntAct	empirical	19423573
HSPD1	SUMO4	HPRD	empirical	16236267
HSPD1	SMAD2	IntAct	empirical	20195357
HSPD1	MYC	IntAct, BioGRID	empirical	17314511
HSPD1	NPHP1	IntAct	empirical	21565611
HSPD1	OGG1	MINT	empirical	18188152
HSPD1	PCK1	BioGRID	empirical	21726808
HSPD1	MED9	IntAct	empirical	15175163
HSPD1	PPP2R1A	HPRD, IntAct	empirical	17540176
HSPD1	PPP2R1B	HPRD, IntAct	empirical	17540176
HSPD1	PPP2R2B	IntAct	empirical	19156129
HSPD1	PPP2R2C	BioGRID	empirical	19156129
HSPD1	ABCF3	Sanger Interaction Map	predicted	15345047
HSPD1	PRKACA	HPRD	empirical	9724719
HSPD1	PRKCE	IntAct	empirical	12169683
HSPD1	MAPK3	MINT	empirical	19935650
HSPD1	MAPK6	IntAct, BioGRID	empirical	20936779
HSPD1	PRNP	HPRD	empirical	8676499
HSPD1	PSMA3	BioGRID	empirical	22079093
HSPD1	BAK1	HPRD, BioGRID	empirical	12070120
HSPD1	BAX	MINT, BioGRID	empirical	16579988 12070120
HSPD1	RAD52	IntAct	empirical	19338310
HSPD1	RAF1	IntAct	empirical	18064632
HSPD1	RASA1	HPRD	empirical	1347942
HSPD1	ACTB	IntAct	empirical	15047060
HSPD1	CLEC7A	IntAct	empirical	21988832
HSPD1	SLC2A4	IntAct	empirical	16396496
HSPD1	BRCA1	IntAct	empirical	21988832
HSPD1	TLR1	HPRD	empirical	16482509
HSPD1	UBC	BioGRID	empirical	16335966 16196087 22178446 20639865 18781797 21987572 20972266 21139048 21890473 21906983
HSPD1	YWHAB	IntAct	empirical	16635246
HSPD1	YWHAG	HPRD	empirical	15324660
HSPD1	YWHAZ	MINT	empirical	15161933
HSPD1	CA2	HPRD, BioGRID	empirical	9890926 10811634
HSPD1	MAP1LC3B	IntAct	empirical	20562859
HSPD1	SF3A2	BioGRID	empirical	12234937
HSPD1	HIST2H2BE	HPRD, BioGRID	empirical	9724719
HSPD1	CASP3	HPRD, BioGRID	empirical	10205159 10205158
HSPD1	CASP9	HPRD	empirical	11230124
HSPD1	IKBKG	MINT, IntAct	empirical	14743216
HSPD1	CD4	BioGRID	empirical	15047060
HSPD1	KIAA0101	BioGRID	empirical	21628590
HSPD1	GFPT2	Sanger Interaction Map	predicted	15345047
HSPD1	CDH1	IntAct	empirical	16212417