APEX1

Summary Top Help

Gene Description:

apurinic/apyrimidinic endonuclease 1; APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms:

APEX1, Ref-1, HAP1, APE, APEX, Apex, REF1, Apex1, APX, REF-1, APE1, APEN

Orthologs:

Human APEX1 (protein-coding), Mouse Apex1 (protein-coding), Rat Apex1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr14:20923290..20925931 (2.64 kb) View in Genome Browser

(Mouse) NCBIM37 - chr14:51544643..51546814 (2.17 kb) View in Genome Browser

(Rat) RGSC3.4 - chr15:26904116..26906227 (2.11 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for APEX1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for APEX1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: 1

Reactome: 8

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 40

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 422

S-glutathionylation of cysteine 99 in the APE1 protein impairs abasic endonuclease activity.
Kim YJ, Kim D, Illuzzi JL, Delaplane S, Su D, Bernier M, Gross ML, Georgiadis MM, Wilson DM
J Mol Biol. 2011
PubMed ID: 22024594
Haplotypes of DNA repair and cell cycle control genes, X-ray exposure, and risk of childhood acute lymphoblastic leukemia.
Chokkalingam AP, Bartley K, Wiemels JL, Metayer C, Barcellos LF, Hansen HM, Aldrich MC, Guha N, Urayama KY, Scélo G, Chang JS, Month SR, Wiencke JK, Buffler PA
Cancer Causes Control. 2011
PubMed ID: 21987080
Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.
Vogel KS, Perez M, Momand JR, Acevedo-Torres K, Hildreth K, Garcia RA, Torres-Ramos CA, Ayala-Torres S, Prihoda TJ, McMahan CA, Walter CA
Mol Reprod Dev. 2011
PubMed ID: 21919107
Genetic polymorphisms in APE1 are associated with renal cell carcinoma risk in a Chinese population.
Cao Q, Qin C, Meng X, Ju X, Ding Q, Wang M, Zhu J, Wang W, Li P, Chen J, Zhang Z, Yin C
Mol Carcinog. 2011
PubMed ID: 21538578
Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.
Yin M, Liao Z, Liu Z, Wang LE, Gomez D, Komaki R, Wei Q
Int J Radiat Oncol Biol Phys. 2011
PubMed ID: 21420246
Alteration of AP-endonuclease1 expression in curcumin-treated fibrotic rats.
Bassiouny AR, Zaky A, Kandeel KM
Ann Hepatol. 2011
PubMed ID: 21911894
Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Vascotto C, Bisetto E, Li M, Zeef LA, D'Ambrosio C, Domenis R, Comelli M, Delneri D, Scaloni A, Altieri F, Mavelli I, Quadrifoglio F, Kelley MR, Tell G
Mol Biol Cell. 2011
PubMed ID: 21865600
Cigarette smoke induces DNA damage and alters base-excision repair and tau levels in the brain of neonatal mice.
La Maestra S, Kisby GE, Micale RT, Johnson J, Kow YW, Bao G, Sheppard C, Stanfield S, Tran H, Woltjer RL, D'Agostini F, Steele VE, De Flora S
Toxicol Sci. 2011
PubMed ID: 21778470
Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.
Busso CS, Wedgeworth CM, Izumi T
Nucleic Acids Res. 2011
PubMed ID: 21727086
APE1 Asp148Glu gene polymorphism and lung cancer risk: a meta-analysis.
Ji YN, Zhan P, Wang J, Qiu LX, Yu LK
Mol Biol Rep. 2011
PubMed ID: 21132382
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
The repair function of the multifunctional DNA repair/redox protein APE1 is neuroprotective after ionizing radiation.
Vasko MR, Guo C, Thompson EL, Kelley MR
DNA Repair (Amst). 2011
PubMed ID: 21741887
Redox factor 1 inhibits the apoptosis process after intracerebral hemorrhage.
Wang D, Guo F, Sun X, Chen L, Li X, Yang Y, Sun H
Neurol Res. 2011
PubMed ID: 21756546
Protective effects of chitosan oligosaccharide on paraquat-induced nephrotoxicity in rats.
Yoon SP, Han MS, Kim JW, Chang IY, Kim HL, Chung JH, Shin BC
Food Chem Toxicol. 2011
PubMed ID: 21570442
Apurinic/apyrimidinic endonuclease 1 inhibits protein kinase C-mediated p66shc phosphorylation and vasoconstriction.
Lee SK, Chung JI, Park MS, Joo HK, Lee EJ, Cho EJ, Park JB, Ryoo S, Irani K, Jeon BH
Cardiovasc Res. 2011
PubMed ID: 21467074
A genetic variation in APE1 is associated with gastric cancer survival in a Chinese population.
Zhao Q, Wang W, Zhang Z, Wang S, Wang M, Zhou J, Gong W, Tan Y, Wang B, Chen G
Cancer Sci. 2011
PubMed ID: 21615620
Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population.
Canbay E, Cakmakoglu B, Zeybek U, Sozen S, Cacina C, Gulluoglu M, Balik E, Bulut T, Yamaner S, Bugra D
Curr Med Res Opin. 2011
PubMed ID: 21561390
Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function.
Yu ET, Hadi MZ
Mutat Res. 2011
PubMed ID: 20633698
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.
Guo JU, Su Y, Zhong C, Ming GL, Song H
Cell. 2011
PubMed ID: 21496894
Novel role of base excision repair in mediating cisplatin cytotoxicity.
Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM
J Biol Chem. 2011
PubMed ID: 21357694
Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population.
Li Z, Guan W, Li MX, Zhong ZY, Qian CY, Yang XQ, Liao L, Li ZP, Wang D
Arch Med Res. 2011
PubMed ID: 21722819
Mad2 haploinsufficiency protects hematopoietic progenitor cells subjected to cell-cycle stress in vivo and to inhibition of redox function of Ape1/Ref-1 in vitro.
Rohrabaugh SL, Hangoc G, Kelley MR, Broxmeyer HE
Exp Hematol. 2011
PubMed ID: 21216274
A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.
Pei DS, Yang XJ, Liu W, Guikema JE, Schrader CE, Strauss PR
Nucleic Acids Res. 2011
PubMed ID: 21172930
Processing of abasic DNA clusters in hApeI-silenced primary fibroblasts exposed to low doses of X-irradiation.
Das P, Sutherland BM
J Biosci. 2011
PubMed ID: 21451252
Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.
Guikema JE, Gerstein RM, Linehan EK, Cloherty EK, Evan-Browning E, Tsuchimoto D, Nakabeppu Y, Schrader CE
J Immunol. 2011
PubMed ID: 21228350
Immunohistochemical analysis of p53, APE1, hMSH2 and ERCC1 proteins in actinic cheilitis and lip squamous cell carcinoma.
Souza LR, Fonseca-Silva T, Pereira CS, Santos EP, Lima LC, Carvalho HA, Gomez RS, Guimarães AL, De Paula AM
Histopathology. 2011
PubMed ID: 21323960
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
Sengupta S, Mantha AK, Mitra S, Bhakat KK
Oncogene. 2011
PubMed ID: 20856196
Lys98 substitution in human AP endonuclease 1 affects the kinetic mechanism of enzyme action in base excision and nucleotide incision repair pathways.
Timofeyeva NA, Koval VV, Ishchenko AA, Saparbaev MK, Fedorova OS
PLoS One. 2011
PubMed ID: 21912662
A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.
Zhou K, Hu D, Lu J, Fan W, Liu H, Chen H, Chen G, Wei Q, Du G, Mao Y, Lu D, Zhou L
BMC Cancer. 2011
PubMed ID: 21429202
Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration.
Albino D, Brizzolara A, Moretti S, Falugi C, Mirisola V, Scaruffi P, Di Candia M, Truini M, Coco S, Bonassi S, Tonini GP
Int J Dev Biol. 2011
PubMed ID: 21425081
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Polymorphisms in base excision repair genes as colorectal cancer risk factors and modifiers of the effect of diets high in red meat.
Brevik A, Joshi AD, Corral R, Onland-Moret NC, Siegmund KD, Le Marchand L, Baron JA, Martinez ME, Haile RW, Ahnen DJ, Sandler RS, Lance P, Stern MC
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 21037106
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
Nucleic Acids Res. 2010
PubMed ID: 20699270
Chinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation.
Borjigin M, Martinez B, Purohit S, de la Rosa G, Arenaz P, Stec B
FEBS J. 2010
PubMed ID: 20955519
Reduced expression of DNA repair and redox signaling protein APE1/Ref-1 impairs human pancreatic cancer cell survival, proliferation, and cell cycle progression.
Jiang Y, Zhou S, Sandusky GE, Kelley MR, Fishel ML
Cancer Invest. 2010
PubMed ID: 20919954
Polymorphic DNA repair and metabolic genes: a multigenic study on gastric cancer.
Palli D, Polidoro S, D'Errico M, Saieva C, Guarrera S, Calcagnile AS, Sera F, Allione A, Gemma S, Zanna I, Filomena A, Testai E, Caini S, Moretti R, Gomez-Miguel MJ, Nesi G, Luzzi I, Ottini L, Masala G, Matullo G, Dogliotti E
Mutagenesis. 2010
PubMed ID: 20817763
Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer.
Kim M, Kang HG, Lee SY, Lee HC, Lee EB, Choi YY, Lee WK, Cho S, Jin G, Jheon HS, Son JW, Lee MH, Jung DK, Cha SI, Kim CH, Kang YM, Kam S, Jung TH, Jheon S, Park JY
Cancer Sci. 2010
PubMed ID: 20731661
Decisive role of apurinic/apyrimidinic endonuclease/Ref-1 in initiation of cell death.
Cho KJ, Kim HJ, Park SC, Kim HW, Kim GW
Mol Cell Neurosci. 2010
PubMed ID: 20637286
Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma.
Xie JY, Li MX, Xiang DB, Mou JH, Qing Y, Zeng LL, Yang ZZ, Guan W, Wang D
Clin Lymphoma Myeloma Leuk. 2010
PubMed ID: 21030352
Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.
Figl A, Scherer D, Nagore E, Bermejo JL, Botella-Estrada R, Gast A, Thirumaran RK, Planelles D, Hemminki K, Schadendorf D, Kumar R
Mutat Res. 2010
PubMed ID: 20601096
Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.
Kuasne H, Rodrigues IS, Losi-Guembarovski R, Reis MB, Fuganti PE, Gregório EP, Libos Junior F, Matsuda HM, Rodrigues MA, Kishima MO, Cólus IM
Mol Biol Rep. 2010
PubMed ID: 20852942
Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.
Yang JL, Tadokoro T, Keijzers G, Mattson MP, Bohr VA
J Biol Chem. 2010
PubMed ID: 20573957
Characterization of nuclear factors modulating the apolipoprotein D promoter during growth arrest: implication of PARP-1, APEX-1 and ERK1/2 catalytic activities.
Levros LC, Do Carmo S, Edouard E, Legault P, Charfi C, Rassart E
Biochim Biophys Acta. 2010
PubMed ID: 20493910
Polymorphisms in the base excision repair pathway and graft-versus-host disease.
Arora M, Lindgren B, Basu S, Nagaraj S, Gross M, Weisdorf D, Thyagarajan B
Leukemia. 2010
PubMed ID: 20574454
Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.
Thyagarajan B, Lindgren B, Basu S, Nagaraj S, Gross MD, Weisdorf DJ, Arora M
Biol Blood Marrow Transplant. 2010
PubMed ID: 20226869
Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation.
Wu HH, Cheng YW, Chang JT, Wu TC, Liu WS, Chen CY, Lee H
Oncogene. 2010
PubMed ID: 20498636
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.
Ho-Pun-Cheung A, Assenat E, Bascoul-Mollevi C, Bibeau F, Boissière-Michot F, Thezenas S, Cellier D, Azria D, Rouanet P, Senesse P, Ychou M, Lopez-Crapez E
Pharmacogenomics J. 2010
PubMed ID: 20644561
Variation within DNA repair pathway genes and risk of multiple sclerosis.
Briggs FB, Goldstein BA, McCauley JL, Zuvich RL, De Jager PL, Rioux JD, Ivinson AJ, Compston A, Hafler DA, Hauser SL, Oksenberg JR, Sawcer SJ, Pericak-Vance MA, Haines JL, Barcellos LF, International Multiple Sclerosis Genetics Consortium
Am J Epidemiol. 2010
PubMed ID: 20522537
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.
Hajkova P, Jeffries SJ, Lee C, Miller N, Jackson SP, Surani MA
Science. 2010
PubMed ID: 20595612
Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base.
Retailleau P, Ishchenko AA, Kuznetsov NA, Saparbaev M, Moréra S
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010
PubMed ID: 20606276
A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.
Huang E, Qu D, Zhang Y, Venderova K, Haque ME, Rousseaux MW, Slack RS, Woulfe JM, Park DS
Nat Cell Biol. 2010
PubMed ID: 20473298
Redox regulation of DNA repair: implications for human health and cancer therapeutic development.
Luo M, He H, Kelley MR, Georgiadis MM
Antioxid Redox Signal. 2010
PubMed ID: 19764832
Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk.
Monsees GM, Kraft P, Chanock SJ, Hunter DJ, Han J
Breast Cancer Res Treat. 2010
PubMed ID: 20496165
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.
Li M, Zhong Z, Zhu J, Xiang D, Dai N, Cao X, Qing Y, Yang Z, Xie J, Li Z, Baugh L, Wang G, Wang D
J Biol Chem. 2010
PubMed ID: 20231292
Probing conformational changes in Ape1 during the progression of base excision repair.
Yu E, Gaucher SP, Hadi MZ
Biochemistry. 2010
PubMed ID: 20377204
Apurinic apyrimidinic endonuclease/redox effector factor 1 immunoreactivity and grading in hepatocellular carcinoma risk of relapse after liver transplantation.
Avellini C, Orsaria M, Baccarani U, Adani GL, Lorenzin D, Bresadola V, Bresadola F, Beltrami CA
Transplant Proc. 2010
PubMed ID: 20534262
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20403997
Genetic polymorphisms of DNA repair genes and chromosomal damage in workers exposed to 1,3-butadiene.
Wang Q, Wang AH, Tan HS, Feng NN, Ye YJ, Feng XQ, Liu G, Zheng YX, Xia ZL
Carcinogenesis. 2010
PubMed ID: 20223788
Possible associations of APE1 polymorphism with susceptibility and HOGG1 polymorphism with prognosis in gastric cancer.
Canbay E, Agachan B, Gulluoglu M, Isbir T, Balik E, Yamaner S, Bulut T, Cacina C, Eraltan IY, Yilmaz A, Bugra D
Anticancer Res. 2010
PubMed ID: 20530453
Dual regulation by apurinic/apyrimidinic endonuclease-1 inhibits gastric epithelial cell apoptosis during Helicobacter pylori infection.
Chattopadhyay R, Bhattacharyya A, Crowe SE
Cancer Res. 2010
PubMed ID: 20332233
APEX1 gene amplification and its protein overexpression in osteosarcoma: correlation with recurrence, metastasis, and survival.
Yang J, Yang D, Cogdell D, Du X, Li H, Pang Y, Sun Y, Hu L, Sun B, Trent J, Chen K, Zhang W
Technol Cancer Res Treat. 2010
PubMed ID: 20218738
Genetic polymorphisms in ATM, ERCC1, APE1 and iASPP genes and lung cancer risk in a population of southeast China.
Deng Q, Sheng L, Su D, Zhang L, Liu P, Lu K, Ma S
Med Oncol. 2010
PubMed ID: 20354815
Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia.
Shi JY, Ren ZH, Jiao B, Xiao R, Yun HY, Chen B, Zhao WL, Zhu Q, Chen Z, Chen SJ
Int J Cancer. 2010
PubMed ID: 20232390
Genetic Variants of XRCC1, APE1, and ADPRT Genes and Risk of Bladder Cancer.
Wang M, Qin C, Zhu J, Yuan L, Fu G, Zhang Z, Yin C
DNA Cell Biol. 2010
PubMed ID: 20218899
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia.
Stetler RA, Gao Y, Zukin RS, Vosler PS, Zhang L, Zhang F, Cao G, Bennett MV, Chen J
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20133634
Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers.
Al-Attar A, Gossage L, Fareed KR, Shehata M, Mohammed M, Zaitoun AM, Soomro I, Lobo DN, Abbotts R, Chan S, Madhusudan S
Br J Cancer. 2010
PubMed ID: 20087352
ERCC1 haplotypes modify bladder cancer risk: a case-control study.
Ricceri F, Guarrera S, Sacerdote C, Polidoro S, Allione A, Fontana D, Destefanis P, Tizzani A, Casetta G, Cucchiarale G, Vineis P, Matullo G
DNA Repair (Amst). 2010
PubMed ID: 20061190
Regulation of signal transducer and activator of transcription 3 enhanceosome formation by apurinic/apyrimidinic endonuclease 1 in hepatic acute phase response.
Ray S, Lee C, Hou T, Bhakat KK, Brasier AR
Mol Endocrinol. 2010
PubMed ID: 20032196
Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension.
Naganuma T, Nakayama T, Sato N, Fu Z, Soma M, Yamaguchi M, Shimodaira M, Aoi N, Usami R
Am J Hypertens. 2010
PubMed ID: 20010699
Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study.
Agalliu I, Kwon EM, Salinas CA, Koopmeiners JS, Ostrander EA, Stanford JL
Cancer Causes Control. 2010
PubMed ID: 19902366
Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic.
Engström KS, Vahter M, Lindh C, Teichert F, Singh R, Concha G, Nermell B, Farmer PB, Strömberg U, Broberg K
Mutat Res. 2010
PubMed ID: 19896490
APEX1 Asp148Glu gene polymorphism is a risk factor for lung cancer in relation to smoking in Japanese.
Osawa K, Miyaishi A, Uchino K, Osawa Y, Inoue N, Nakarai C, Tsutou A, Kido Y, Yoshimura M, Tsubota N, Takahashi J
Asian Pac J Cancer Prev. 2010
PubMed ID: 21198260
A novel envelope mediated post entry restriction of murine leukaemia virus in human cells is Ref1/TRIM5α independent.
Oliveira NM, Trikha R, McKnight Á
Retrovirology. 2010
PubMed ID: 20929586
Genetic and biochemical characterization of human AP endonuclease 1 mutants deficient in nucleotide incision repair activity.
Gelin A, Redrejo-Rodríguez M, Laval J, Fedorova OS, Saparbaev M, Ishchenko AA
PLoS One. 2010
PubMed ID: 20808930
Expression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lens.
Zhang Y, Zhang L, Zhang L, Bai J, Ge H, Liu P
Mol Vis. 2010
PubMed ID: 20808729
Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast cancers in a Polish population.
Jelonek K, Gdowicz-Klosok A, Pietrowska M, Borkowska M, Korfanty J, Rzeszowska-Wolny J, Widlak P
J Appl Genet. 2010
PubMed ID: 20720310
Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1.
Naidu MD, Mason JM, Pica RV, Fung H, Peña LA
J Radiat Res (Tokyo). 2010
PubMed ID: 20679741
Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.
Jugessur A, Shi M, Gjessing HK, Lie RT, Wilcox AJ, Weinberg CR, Christensen K, Boyles AL, Daack-Hirsch S, Nguyen TT, Christiansen L, Lidral AC, Murray JC
PLoS One. 2010
PubMed ID: 20634891
XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium.
Chen PL, Yeh KT, Tsai YY, Koeh H, Liu YL, Lee H, Cheng YW
Mol Vis. 2010
PubMed ID: 20577654
The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients.
Kim SJ, Hwang SH, Kim IJ, Lee MK, Lee CH, Lee SY, Lee EY
J Exp Clin Cancer Res. 2010
PubMed ID: 20540786
DNA repair genes in endometriosis.
Attar R, Cacina C, Sozen S, Attar E, Agachan B
Genet Mol Res. 2010
PubMed ID: 20391347
Single cell RT-PCR on mouse embryos: a general approach for developmental biology.
Mann W, Haaf T
Methods Mol Biol. 2010
PubMed ID: 20300987
DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.
Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD
Neuro Oncol. 2010
PubMed ID: 20150366
SIRT1 deacetylates APE1 and regulates cellular base excision repair.
Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K
Nucleic Acids Res. 2010
PubMed ID: 19934257
APE1/Ref-1 in Alzheimer's disease: an immunohistochemical study.
Marcon G, Tell G, Perrone L, Garbelli R, Quadrifoglio F, Tagliavini F, Giaccone G
Neurosci Lett. 2009
PubMed ID: 19782121
Apex1 can cleave complex clustered DNA lesions in cells.
Malyarchuk S, Castore R, Harrison L
DNA Repair (Amst). 2009
PubMed ID: 19800300
Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice.
Goula AV, Berquist BR, Wilson DM, Wheeler VC, Trottier Y, Merienne K
PLoS Genet. 2009
PubMed ID: 19997493
APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells.
Wang D, Xiang DB, Yang XQ, Chen LS, Li MX, Zhong ZY, Zhang YS
Lung Cancer. 2009
PubMed ID: 19324449
Apurinic/apyrimidinic endonuclease 1 is a key modulator of keratinocyte inflammatory responses.
Lee HM, Yuk JM, Shin DM, Yang CS, Kim KK, Choi DK, Liang ZL, Kim JM, Jeon BH, Kim CD, Lee JH, Jo EK
J Immunol. 2009
PubMed ID: 19846872
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE1/Ref-1) in human ovarian cancer and indentification of the therapeutic potential of APE1/Ref-1 inhibitor.
Zhang Y, Wang J, Xiang D, Wang D, Xin X
Int J Oncol. 2009
PubMed ID: 19787261
The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies.
Gu D, Wang M, Wang M, Zhang Z, Chen J
Mutagenesis. 2009
PubMed ID: 19762350
Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
Harris JL, Jakob B, Taucher-Scholz G, Dianov GL, Becherel OJ, Lavin MF
Hum Mol Genet. 2009
PubMed ID: 19643912
A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers.
Young RP, Hopkins RJ, Hay BA, Epton MJ, Mills GD, Black PN, Gardner HD, Sullivan R, Gamble GD
Postgrad Med J. 2009
PubMed ID: 19789190
Polymorphisms of DNA base-excision repair genes APE/Ref-1 and XRCC1 are not associated with the risk for Graves' disease.
Doğru-Abbasoğlu S, Tanrikulu S, Ademoğlu E, Erbil Y, Ozderya A, Karadağ B, Uysal M
Cell Biochem Funct. 2009
PubMed ID: 19711438
Haplotype-based case-control study between human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and cerebral infarction.
Naganuma T, Nakayama T, Sato N, Fu Z, Yamaguchi M, Soma M, Aoi N, Usami R, Doba N, Hinohara S
Clin Biochem. 2009
PubMed ID: 19631633
Genetic polymorphisms in DNA repair gene APE1, XRCC1 and XPD and the risk of pre-eclampsia.
Vural P, Değirmencioğlu S, Doğru-Abbasoğlu S, Saral NY, Akgül C, Uysal M
Eur J Obstet Gynecol Reprod Biol. 2009
PubMed ID: 19592152
Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility.
Lu J, Zhang S, Chen D, Wang H, Wu W, Wang X, Lei Y, Wang J, Qian J, Fan W, Hu Z, Jin L, Shen H, Huang W, Wei Q, Lu D
FASEB J. 2009
PubMed ID: 19541747
Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression.
Curtis CD, Thorngren DL, Ziegler YS, Sarkeshik A, Yates JR, Nardulli AM
Mol Endocrinol. 2009
PubMed ID: 19460860
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
Expression of redox factor-1 in early injury period after liver transplantation in rat model.
Zhang P, Du X, Sun Z, Xu L
Cell Mol Immunol. 2009
PubMed ID: 19728933
Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes.
Sabouri Z, Okazaki IM, Shinkura R, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T
Int Immunol. 2009
PubMed ID: 19556307
HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation.
Loboda A, Stachurska A, Dorosz J, Zurawski M, Wegrzyn J, Kozakowska M, Jozkowicz A, Dulak J
Vascul Pharmacol. 2009
PubMed ID: 19524065
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
Kweekel DM, Antonini NF, Nortier JW, Punt CJ, Gelderblom H, Guchelaar HJ
Br J Cancer. 2009
PubMed ID: 19536092
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.
Barnes T, Kim WC, Mantha AK, Kim SE, Izumi T, Mitra S, Lee CH
Nucleic Acids Res. 2009
PubMed ID: 19401441
Human AP endonuclease 1 stimulates multiple-turnover base excision by alkyladenine DNA glycosylase.
Baldwin MR, O'Brien PJ
Biochemistry. 2009
PubMed ID: 19449863
Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists.
Andreassi MG, Foffa I, Manfredi S, Botto N, Cioppa A, Picano E
Mutat Res. 2009
PubMed ID: 19393248
The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice.
Kim HW, Cho KJ, Park SC, Kim HJ, Kim GW
Brain Res. 2009
PubMed ID: 19374886
Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking.
Agaçhan B, Küçükhüseyin O, Aksoy P, Turna A, Yaylim I, Görmüs U, Ergen A, Zeybek U, Dalan B, Isbir T
Anticancer Res. 2009
PubMed ID: 19528510
Downregulation of APE1/Ref-1 is involved in the senescence of mesenchymal stem cells.
Heo JY, Jing K, Song KS, Seo KS, Park JH, Kim JS, Jung YJ, Hur GM, Jo DY, Kweon GR, Yoon WH, Lim K, Hwang BD, Jeon BH, Park JI
Stem Cells. 2009
PubMed ID: 19492297
Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.
McNeill DR, Lam W, DeWeese TL, Cheng YC, Wilson DM
Mol Cancer Res. 2009
PubMed ID: 19470598
Tumor necrosis factor (TNF)-alpha-induced IL-8 expression in gastric epithelial cells: role of reactive oxygen species and AP endonuclease-1/redox factor (Ref)-1.
O'Hara AM, Bhattacharyya A, Bai J, Mifflin RC, Ernst PB, Mitra S, Crowe SE
Cytokine. 2009
PubMed ID: 19376732
Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice.
Unnikrishnan A, Raffoul JJ, Patel HV, Prychitko TM, Anyangwe N, Meira LB, Friedberg EC, Cabelof DC, Heydari AR
Free Radic Biol Med. 2009
PubMed ID: 19268524
Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.
Chang-Claude J, Ambrosone CB, Lilla C, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, Popanda O
Br J Cancer. 2009
PubMed ID: 19367277
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Micronucleus occurrence related to base excision repair gene polymorphisms in Chinese workers occupationally exposed to vinyl chloride monomer.
Wen-Bin M, Wei W, Yu-Lan Q, Fang J, Zhao-Lin X
J Occup Environ Med. 2009
PubMed ID: 19369898
Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.
Michiels S, Laplanche A, Boulet T, Dessen P, Guillonneau B, Méjean A, Desgrandchamps F, Lathrop M, Sarasin A, Benhamou S
Carcinogenesis. 2009
PubMed ID: 19237606
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.
Busso CS, Iwakuma T, Izumi T
Oncogene. 2009
PubMed ID: 19219073
Bladder cancer and polymorphisms of DNA repair genes (XRCC1, XRCC3, XPD, XPG, APE1, hOGG1).
Narter KF, Ergen A, Agaçhan B, Görmüs U, Timirci O, Isbir T
Anticancer Res. 2009
PubMed ID: 19414392
[Preparation and characterization of rabbit anti-human apurinic/apyrimidinic endonuclease(APE1) polyclonal antibody]
Cao XJ, Dai N, Yi WJ, Li ZP, Yang YX, Wang D, Hu CM
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009
PubMed ID: 19351502
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P
Cancer Res. 2009
PubMed ID: 19339270
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G
Mol Cell Biol. 2009
PubMed ID: 19188445
Ape1/Ref-1 induces glial cell-derived neurotropic factor (GDNF) responsiveness by upregulating GDNF receptor alpha1 expression.
Kim MH, Kim HB, Acharya S, Sohn HM, Jun JY, Chang IY, You HJ
Mol Cell Biol. 2009
PubMed ID: 19188437
Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.
Castillo-Acosta VM, Ruiz-Pérez LM, Yang W, González-Pacanowska D, Vidal AE
Nucleic Acids Res. 2009
PubMed ID: 19181704
The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis.
Zou GM, Karikari C, Kabe Y, Handa H, Anders RA, Maitra A
J Cell Physiol. 2009
PubMed ID: 19097035
Association between genetic polymorphisms of DNA base excision repair genes and evolution of precancerous gastric lesions in a Chinese population.
Li WQ, Zhang L, Ma JL, Zhang Y, Li JY, Pan KF, You WC
Carcinogenesis. 2009
PubMed ID: 19147860
Influence of XPD and APE1 DNA repair gene polymorphism on bladder cancer susceptibility in north India.
Gangwar R, Ahirwar D, Mandhani A, Mittal RD
Urology. 2009
PubMed ID: 19041121
S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis.
Tomasi ML, Iglesias-Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC
Gastroenterology. 2009
PubMed ID: 18983843
Impact of nucleotide excision repair ERCC2 and base excision repair APEX1 genes polymorphism and its association with recurrence after adjuvant BCG immunotherapy in bladder cancer patients of North India.
Gangawar R, Ahirwar D, Mandhani A, Mittal RD
Med Oncol. 2009
PubMed ID: 19242824
Single nucleotide polymorphisms in DNA repair genes XRCC1 and APEX1 in progression and survival of primary cutaneous melanoma patients.
Figl A, Scherer D, Nagore E, Bermejo JL, Dickes E, Thirumaran RK, Gast A, Hemminki K, Kumar R, Schadendorf D
Mutat Res. 2009
PubMed ID: 19073198
MiTF regulates cellular response to reactive oxygen species through transcriptional regulation of APE-1/Ref-1.
Liu F, Fu Y, Meyskens FL
J Invest Dermatol. 2009
PubMed ID: 18971960
Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway.
Lee HM, Jeon BH, Won KJ, Lee CK, Park TK, Choi WS, Bae YM, Kim HS, Lee SK, Park SH, Irani K, Kim B
Circ Res. 2009
PubMed ID: 19038866
A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility.
Vineis P, Manuguerra M, Kavvoura FK, Guarrera S, Allione A, Rosa F, Di Gregorio A, Polidoro S, Saletta F, Ioannidis JP, Matullo G
J Natl Cancer Inst. 2009
PubMed ID: 19116388
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.
Simeonov A, Kulkarni A, Dorjsuren D, Jadhav A, Shen M, McNeill DR, Austin CP, Wilson DM
PLoS One. 2009
PubMed ID: 19484131
[The expression of APE1 and its correlation with prognostic significance after 252Cf radiotherapy in cervical cancer]
Qing Y, Wang D, Lei X, Xiang DB, Li MX, Li ZP, Shan JL
Sichuan Da Xue Xue Bao Yi Xue Ban. 2009
PubMed ID: 19292061
A polymorphism in the APE1 gene promoter is associated with lung cancer risk.
Lo YL, Jou YS, Hsiao CF, Chang GC, Tsai YH, Su WC, Chen KY, Chen YM, Huang MS, Hu CY, Chen CJ, Hsiung CA
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124501
Association and interactions between DNA repair gene polymorphisms and adult glioma.
Liu Y, Scheurer ME, El-Zein R, Cao Y, Do KA, Gilbert M, Aldape KD, Wei Q, Etzel C, Bondy ML
Cancer Epidemiol Biomarkers Prev. 2009
PubMed ID: 19124499
Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.
Chang JS, Wrensch MR, Hansen HM, Sison JD, Aldrich MC, Quesenberry CP, Seldin MF, Kelsey KT, Wiencke JK
Carcinogenesis. 2009
PubMed ID: 19029194
Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
May A, Kirchner R, Müller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T
Biol Reprod. 2009
PubMed ID: 18784354
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/ref-1) and DNA damage in the caudal region of acute and chronic spinal cord injured rats treated by embryonic neural stem cells.
DAGCI T, ARMAGAN G, KONYALIOGLU S, YALCIN A
Physiol Res. 2009
PubMed ID: 18637713
Nitric oxide initiates progression of human melanoma via a feedback loop mediated by apurinic/apyrimidinic endonuclease-1/redox factor-1, which is inhibited by resveratrol.
Yang Z, Yang S, Misner BJ, Chiu R, Liu F, Meyskens FL
Mol Cancer Ther. 2008
PubMed ID: 19074850
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Case-only study of interactions between DNA repair genes (hMLH1, APEX1, MGMT, XRCC1 and XPD) and low-frequency electromagnetic fields in childhood acute leukemia.
Yang Y, Jin X, Yan C, Tian Y, Tang J, Shen X
Leuk Lymphoma. 2008
PubMed ID: 19052983
Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1.
Chattopadhyay R, Das S, Maiti AK, Boldogh I, Xie J, Hazra TK, Kohno K, Mitra S, Bhakat KK
Mol Cell Biol. 2008
PubMed ID: 18809583
Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.
Fitzgerald ME, Drohat AC
J Biol Chem. 2008
PubMed ID: 18805789
Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1.
Azam S, Jouvet N, Jilani A, Vongsamphanh R, Yang X, Yang S, Ramotar D
J Biol Chem. 2008
PubMed ID: 18776186
[Expression of Ref-1 in hippocampus CA1 area of rats with Alzheimer's disease]
Wu HQ, Yao L, Du Y, Zhang GL, Zhang R, Liu JJ, Pu N
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008
PubMed ID: 19084962
International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 18990748
Role of the multifunctional DNA repair and redox signaling protein Ape1/Ref-1 in cancer and endothelial cells: small-molecule inhibition of the redox function of Ape1.
Luo M, Delaplane S, Jiang A, Reed A, He Y, Fishel M, Nyland RL, Borch RF, Qiao X, Georgiadis MM, Kelley MR
Antioxid Redox Signal. 2008
PubMed ID: 18627350
Implications of XRCC1, XPD and APE1 gene polymorphism in North Indian population: a comparative approach in different ethnic groups worldwide.
Gangwar R, Manchanda PK, Mittal RD
Genetica. 2008
PubMed ID: 18946634
Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma.
Wang SS, Maurer MJ, Morton LM, Habermann TM, Davis S, Cozen W, Lynch CF, Severson RK, Rothman N, Chanock SJ, Hartge P, Cerhan JR
Leukemia. 2008
PubMed ID: 18830263
APE1/Ref-1 promotes the effect of angiotensin II on Ca2+ -activated K+ channel in human endothelial cells via suppression of NADPH oxidase.
Park WS, Ko EA, Jung ID, Son YK, Kim HK, Kim N, Park SY, Hong KW, Park YM, Choi TH, Han J
Arch Pharm Res. 2008
PubMed ID: 18958420
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
Melatonin preserves fetal growth in rats by protecting against ischemia/reperfusion-induced oxidative/nitrosative mitochondrial damage in the placenta.
Nagai R, Watanabe K, Wakatsuki A, Hamada F, Shinohara K, Hayashi Y, Imamura R, Fukaya T
J Pineal Res. 2008
PubMed ID: 18373555
Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease.
Parildar-Karpuzoğlu H, Doğru-Abbasoğlu S, Hanagasi HA, Karadağ B, Gürvit H, Emre M, Uysal M
Neurosci Lett. 2008
PubMed ID: 18672023
Association between polymorphisms in DNA base excision repair genes XRCC1, APE1, and ADPRT and differentiated thyroid carcinoma.
Chiang FY, Wu CW, Hsiao PJ, Kuo WR, Lee KW, Lin JC, Liao YC, Juo SH
Clin Cancer Res. 2008
PubMed ID: 18779313
Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress.
Li MX, Wang D, Zhong ZY, Xiang DB, Li ZP, Xie JY, Yang ZZ, Jin F, Qing Y
Free Radic Biol Med. 2008
PubMed ID: 18515104
Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease.
Georgiadis MM, Luo M, Gaur RK, Delaplane S, Li X, Kelley MR
Mutat Res. 2008
PubMed ID: 18579163
Polygenic Model of DNA-Repair Genetic Polymorphisms in Human Breast Cancer Risk.
Smith TR, Levine EA, Freimanis RI, Akman SA, Allen GO, Hoang KN, Liu-Mares W, Hu JJ
Carcinogenesis. 2008
PubMed ID: 18701435
APE/Ref-1 makes fine-tuning of CD40-induced B cell proliferation.
Merluzzi S, Gri G, Gattei V, Pagano M, Pucillo C
Mol Immunol. 2008
PubMed ID: 18617267
Influence of DNA repair gene polymorphisms on the initial repair of MMS-induced DNA damage in human lymphocytes as measured by the alkaline comet assay.
Ryk C, Routledge MN, Allan JM, Wild CP, Kumar R, Lambert B, Hou S
Environ Mol Mutagen. 2008
PubMed ID: 18627000
APE1 and XRCC3 polymorphisms and myocardial infarction.
Tekeli A, Isbir S, Ergen A, Görmüş U, Bozkurt N, Timirci O, Arsan S, Isbir T
In Vivo. 2008
PubMed ID: 18712175
Expression of apurinic/apyrimidinic endonuclease-1 (APE-1) in H. pylori-associated gastritis, gastric adenoma, and gastric cancer.
Futagami S, Hiratsuka T, Shindo T, Horie A, Hamamoto T, Suzuki K, Kusunoki M, Miyake K, Gudis K, Crowe SE, Tsukui T, Sakamoto C
Helicobacter. 2008
PubMed ID: 18466396
Characterization of abasic endonuclease activity of human Ape1 on alternative substrates, as well as effects of ATP and sequence context on AP site incision.
Berquist BR, McNeill DR, Wilson DM
J Mol Biol. 2008
PubMed ID: 18439621
Unusual role of a cysteine residue in substrate binding and activity of human AP-endonuclease 1.
Mantha AK, Oezguen N, Bhakat KK, Izumi T, Braun W, Mitra S
J Mol Biol. 2008
PubMed ID: 18436236
Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk.
Tse D, Zhai R, Zhou W, Heist RS, Asomaning K, Su L, Lynch TJ, Wain JC, Christiani DC, Liu G
Cancer Causes Control. 2008
PubMed ID: 18478337
Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis.
Coppedè F, Gerfo AL, Carlesi C, Piazza S, Mancuso M, Pasquali L, Murri L, Migliore L, Siciliano G
Neurobiol Aging. 2008
PubMed ID: 18482781
Human abasic endonuclease action on multilesion abasic clusters: implications for radiation-induced biological damage.
Paap B, Wilson DM, Sutherland BM
Nucleic Acids Res. 2008
PubMed ID: 18353858
Alteration of APE1/ref-1 expression in non-small cell lung cancer: the implications of impaired extracellular superoxide dismutase and catalase antioxidant systems.
Yoo DG, Song YJ, Cho EJ, Lee SK, Park JB, Yu JH, Lim SP, Kim JM, Jeon BH
Lung Cancer. 2008
PubMed ID: 18061304
Redox factor-1 mediates NF-kappaB nuclear translocation for LPS-induced iNOS expression in murine macrophage cell line RAW 264.7.
Song JD, Lee SK, Kim KM, Kim JW, Kim JM, Yoo YH, Park YC
Immunology. 2008
PubMed ID: 18028373
Bcl2 inhibits abasic site repair by down-regulating APE1 endonuclease activity.
Zhao J, Gao F, Zhang Y, Wei K, Liu Y, Deng X
J Biol Chem. 2008
PubMed ID: 18263880
Prevalence of BER gene polymorphisms in sporadic breast cancer.
Ali MF, Meza JL, Rogan EG, Chakravarti D
Oncol Rep. 2008
PubMed ID: 18357393
Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity.
Guo Y, Chen J, Zhao T, Fan Z
Mol Immunol. 2008
PubMed ID: 18179823
Tat-APE1/ref-1 protein inhibits TNF-alpha-induced endothelial cell activation.
Song YJ, Lee JY, Joo HK, Kim HS, Lee SK, Lee KH, Cho CH, Park JB, Jeon BH
Biochem Biophys Res Commun. 2008
PubMed ID: 18206643
Interaction of APE1 and other repair proteins with DNA duplexes imitating intermediates of DNA repair and replication.
Dyrkheeva NS, Khodyreva SN, Lavrik OI
Biochemistry (Mosc). 2008
PubMed ID: 18393760
Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.
Zaky A, Busso C, Izumi T, Chattopadhyay R, Bassiouny A, Mitra S, Bhakat KK
Nucleic Acids Res. 2008
PubMed ID: 18208837
Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.
Haga S, Terui K, Fukai M, Oikawa Y, Irani K, Furukawa H, Todo S, Ozaki M
J Hepatol. 2008
PubMed ID: 18191273
Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids.
Seiple LA, Cardellina JH, Akee R, Stivers JT
Mol Pharmacol. 2008
PubMed ID: 18042731
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
DNA repair genetic polymorphisms and risk of colorectal cancer in the Czech Republic.
Pardini B, Naccarati A, Novotny J, Smerhovsky Z, Vodickova L, Polakova V, Hanova M, Slyskova J, Tulupova E, Kumar R, Bortlik M, Barale R, Hemminki K, Vodicka P
Mutat Res. 2008
PubMed ID: 17991492
Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth.
Fishel ML, He Y, Reed AM, Chin-Sinex H, Hutchins GD, Mendonca MS, Kelley MR
DNA Repair (Amst). 2008
PubMed ID: 17974506
Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.
Noike T, Miwa S, Soeda J, Kobayashi A, Miyagawa S
Hum Pathol. 2008
PubMed ID: 17949784
Dipole-dipole interaction stabilizes the transition state of apurinic/apyrimidinic endonuclease--abasic site interaction.
Adhikari S, Uren A, Roy R
J Biol Chem. 2008
PubMed ID: 18025089
Association of MUTYH Gln324His and APEX1 Asp148Glu with colorectal cancer and smoking in a Japanese population.
Kasahara M, Osawa K, Yoshida K, Miyaishi A, Osawa Y, Inoue N, Tsutou A, Tabuchi Y, Tanaka K, Yamamoto M, Shimada E, Takahashi J
J Exp Clin Cancer Res. 2008
PubMed ID: 18823566
Association of polymorphisms in base excision repair genes with the risk of breast cancer: a case-control study in North Indian women.
Mitra AK, Singh N, Singh A, Garg VK, Agarwal A, Sharma M, Chaturvedi R, Rath SK
Oncol Res. 2008
PubMed ID: 18669164
Significance of amino acid substitution variants of DNA repair genes in radiosusceptibility of cervical cancer patients; a pilot study.
Farkasova T, Gurska S, Witkovsky V, Gabelova A
Neoplasma. 2008
PubMed ID: 18505345
Association of genetic polymorphism of the DNA base excision repair gene (APE-1 Asp/148 Glu) and HPV type (16/18) with the risk of cervix cancer in north Indian population.
Shekari M, Sobti RC, Tamandani DM, Malekzadeh K, Kaur P, Suri V
Cancer Biomark. 2008
PubMed ID: 18503157
APE1/Ref-1 regulates PTEN expression mediated by Egr-1.
Fantini D, Vascotto C, Deganuto M, Bivi N, Gustincich S, Marcon G, Quadrifoglio F, Damante G, Bhakat KK, Mitra S, Tell G
Free Radic Res. 2008
PubMed ID: 18324520
Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.
Huang WY, Gao YT, Rashid A, Sakoda LC, Deng J, Shen MC, Wang BS, Han TQ, Zhang BH, Chen BE, Rosenberg PS, Chanock SJ, Hsing AW
Carcinogenesis. 2008
PubMed ID: 17984110
DNA repair polymorphisms modify bladder cancer risk: a multi-factor analytic strategy.
Andrew AS, Karagas MR, Nelson HH, Guarrera S, Polidoro S, Gamberini S, Sacerdote C, Moore JH, Kelsey KT, Demidenko E, Vineis P, Matullo G
Hum Hered. 2008
PubMed ID: 17898541
TRAF2 and p38 are involved in B cells CD40-mediated APE/Ref-1 nuclear translocation: a novel pathway in B cell activation.
Merluzzi S, D'Orlando O, Leonardi A, Vitale G, Pucillo C
Mol Immunol. 2008
PubMed ID: 17599408
Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis.
Cattaneo F, Molatore S, Mihalatos M, Apessos A, Venesio T, Bione S, Grignani P, Nasioulas G, Ranzani GN
Genet Med. 2007
PubMed ID: 18091433
ATF4-dependent oxidative induction of the DNA repair enzyme Ape1 counteracts arsenite cytotoxicity and suppresses arsenite-mediated mutagenesis.
Fung H, Liu P, Demple B
Mol Cell Biol. 2007
PubMed ID: 17938202
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.
Guikema JE, Linehan EK, Tsuchimoto D, Nakabeppu Y, Strauss PR, Stavnezer J, Schrader CE
J Exp Med. 2007
PubMed ID: 18025127
Polymorphisms in three base excision repair genes and breast cancer risk in Thai women.
Sangrajrang S, Schmezer P, Burkholder I, Waas P, Boffetta P, Brennan P, Bartsch H, Wiangnon S, Popanda O
Breast Cancer Res Treat. 2007
PubMed ID: 17922186
Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.
Matakidou A, el Galta R, Webb EL, Rudd MF, Bridle H, GELCAPS Consortium, Eisen T, Houlston RS
Hum Mol Genet. 2007
PubMed ID: 17855454
Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway.
Cesaratto L, Calligaris SD, Vascotto C, Deganuto M, Bellarosa C, Quadrifoglio F, Ostrow JD, Tiribelli C, Tell G
J Mol Med. 2007
PubMed ID: 17479230
Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
Li C, Hu Z, Lu J, Liu Z, Wang LE, El-Naggar AK, Sturgis EM, Spitz MR, Wei Q
Cancer. 2007
PubMed ID: 17614107
Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over.
Ward JO, Reinholdt LG, Motley WW, Niswander LM, Deacon DC, Griffin LB, Langlais KK, Backus VL, Schimenti KJ, O'Brien MJ, Eppig JJ, Schimenti JC
PLoS Genet. 2007
PubMed ID: 17784788
A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China.
Mahabir S, Abnet CC, Qiao YL, Ratnasinghe LD, Dawsey SM, Dong ZW, Taylor PR, Mark SD
J Epidemiol Community Health. 2007
PubMed ID: 17630376
Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury.
Gurusamy N, Malik G, Gorbunov NV, Das DK
Free Radic Biol Med. 2007
PubMed ID: 17602955
APEX/Ref-1 (apurinic/apyrimidic endonuclease DNA-repair gene) expression in human and ascidian (Ciona intestinalis) gametes and embryos.
El-Mouatassim S, Bilotto S, Russo GL, Tosti E, Menezo Y
Mol Hum Reprod. 2007
PubMed ID: 17567600
Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk.
De Ruyck K, Szaumkessel M, De Rudder I, Dehoorne A, Vral A, Claes K, Velghe A, Van Meerbeeck J, Thierens H
Mutat Res. 2007
PubMed ID: 17531525
Susceptibility to arsenic-induced skin lesions from polymorphisms in base excision repair genes.
Breton CV, Zhou W, Kile ML, Houseman EA, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC
Carcinogenesis. 2007
PubMed ID: 17374727
Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure.
Bianchi M, Bellini A, Cervelli M, Degan P, Marcocci L, Martini F, Scatteia M, Mariottini P, Amendola R
Biochim Biophys Acta. 2007
PubMed ID: 17363080
Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.
Liu Y, Prasad R, Beard WA, Kedar PS, Hou EW, Shock DD, Wilson SH
J Biol Chem. 2007
PubMed ID: 17355977
[Multifunctional human apurinic/apyrimidinic endonuclease 1: the role of additional functions]
Dyrkheeva NS, Khodyreva SN, Lavrik OI
Mol Biol (Mosk). 2007
PubMed ID: 17685223
Effect of fenofibrate on oxidative DNA damage and on gene expression related to cell proliferation and apoptosis in rats.
Nishimura J, Dewa Y, Muguruma M, Kuroiwa Y, Yasuno H, Shima T, Jin M, Takahashi M, Umemura T, Mitsumori K
Toxicol Sci. 2007
PubMed ID: 17264098
Genetic polymorphisms and treatment response in advanced non-small cell lung cancer.
Su D, Ma S, Liu P, Jiang Z, Lv W, Zhang Y, Deng Q, Smith S, Yu H
Lung Cancer. 2007
PubMed ID: 17222938
Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials.
Kuptsova N, Kopecky KJ, Godwin J, Anderson J, Hoque A, Willman CL, Slovak ML, Ambrosone CB
Blood. 2007
PubMed ID: 17197435
Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA.
Yang B, Chen K, Zhang C, Huang S, Zhang H
J Biol Chem. 2007
PubMed ID: 17272283
Effects of base excision repair gene polymorphisms on pancreatic cancer survival.
Li D, Li Y, Jiao L, Chang DZ, Beinart G, Wolff RA, Evans DB, Hassan MM, Abbruzzese JL
Int J Cancer. 2007
PubMed ID: 17230526
Spatial coordination of cell-adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injury.
Gorbunov NV, Das DK, Goswami SK, Gurusamy N, Atkins JL
Antioxid Redox Signal. 2007
PubMed ID: 17280489
Genetic variation in the base excision repair pathway and bladder cancer risk.
Figueroa JD, Malats N, Real FX, Silverman D, Kogevinas M, Chanock S, Welch R, Dosemeci M, Tardón A, Serra C, Carrato A, García-Closas R, Castaño-Vinyals G, Rothman N, García-Closas M
Hum Genet. 2007
PubMed ID: 17203305
[Study of susceptibility of chromosomal damage induced by vinyl chloride monomer associated with genetic polymorphism in APE1, XRCC1]
Qiu Y, Zhu S, Liu J, Xia Z
Wei Sheng Yan Jiu. 2007
PubMed ID: 17555083
Down-regulation of apurinic/apyrimidinic endonuclease 1/redox factor-1 expression by soy isoflavones enhances prostate cancer radiotherapy in vitro and in vivo.
Raffoul JJ, Banerjee S, Singh-Gupta V, Knoll ZE, Fite A, Zhang H, Abrams J, Sarkar FH, Hillman GG
Cancer Res. 2007
PubMed ID: 17332344
Role of active site tyrosines in dynamic aspects of DNA binding by AP endonuclease.
Melo LF, Mundle ST, Fattal MH, O'Regan NE, Strauss PR
DNA Repair (Amst). 2007
PubMed ID: 17218168
Mechanism of interaction between human 8-oxoguanine-DNA glycosylase and AP endonuclease.
Sidorenko VS, Nevinsky GA, Zharkov DO
DNA Repair (Amst). 2007
PubMed ID: 17126083
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain.
Zou GM, Luo MH, Reed A, Kelley MR, Yoder MC
Blood. 2007
PubMed ID: 17053053
The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.
Hall J, Hashibe M, Boffetta P, Gaborieau V, Moullan N, Chabrier A, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Holcatova I, Hung RJ, McKay J, Canzian F, Brennan P
Carcinogenesis. 2007
PubMed ID: 17040931
Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects.
Vodicka P, Stetina R, Polakova V, Tulupova E, Naccarati A, Vodickova L, Kumar R, Hanova M, Pardini B, Slyskova J, Musak L, De Palma G, Soucek P, Hemminki K
Carcinogenesis. 2007
PubMed ID: 17028303
Genetic variation in base excision repair genes and the prevalence of advanced colorectal adenoma.
Berndt SI, Huang WY, Fallin MD, Helzlsouer KJ, Platz EA, Weissfeld JL, Church TR, Welch R, Chanock SJ, Hayes RB
Cancer Res. 2007
PubMed ID: 17283177
Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.
Manuguerra M, Matullo G, Veglia F, Autrup H, Dunning AM, Garte S, Gormally E, Malaveille C, Guarrera S, Polidoro S, Saletta F, Peluso M, Airoldi L, Overvad K, Raaschou-Nielsen O, Clavel-Chapelon F, Linseisen J, Boeing H, Trichopoulos D, Kalandidi A, Palli D, Krogh V, Tumino R, Panico S, Bueno-De-Mesquita HB, Peeters PH, Lund E, Pera G, Martinez C, Amiano P, Barricarte A, Tormo MJ, Quiros JR, Berglund G, Janzon L, Jarvholm B, Day NE, Allen NE, Saracci R, Kaaks R, Ferrari P, Riboli E, Vineis P
Carcinogenesis. 2007
PubMed ID: 16956909
Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway.
Daviet S, Couvé-Privat S, Gros L, Shinozuka K, Ide H, Saparbaev M, Ishchenko AA
DNA Repair (Amst). 2007
PubMed ID: 16978929
GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study.
Breton CV, Kile ML, Catalano PJ, Hoffman E, Quamruzzaman Q, Rahman M, Mahiuddin G, Christiani DC
Environ Health. 2007
PubMed ID: 18053222
Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates.
Wong HK, Muftuoglu M, Beck G, Imam SZ, Bohr VA, Wilson DM
Nucleic Acids Res. 2007
PubMed ID: 17567611
Subcellular localization of APE1/Ref-1 in human hepatocellular carcinoma: possible prognostic significance.
Di Maso V, Avellini C, Crocè LS, Rosso N, Quadrifoglio F, Cesaratto L, Codarin E, Bedogni G, Beltrami CA, Tell G, Tiribelli C
Mol Med. 2007
PubMed ID: 17515960
Nitric oxide controls nuclear export of APE1/Ref-1 through S-nitrosation of cysteines 93 and 310.
Qu J, Liu GH, Huang B, Chen C
Nucleic Acids Res. 2007
PubMed ID: 17403694
Experimental study enhancing the chemosensitivity of multiple myeloma to melphalan by using a tissue-specific APE1-silencing RNA expression vector.
Yang ZZ, Chen XH, Wang D
Clin Lymphoma Myeloma. 2007
PubMed ID: 17324338
Influence of polymorphisms at loci encoding DNA repair proteins on cancer susceptibility and G2 chromosomal radiosensitivity.
Wilding CS, Curwen GB, Tawn EJ, Sheng X, Winther JF, Chakraborty R, Boice JD
Environ Mol Mutagen. 2007
PubMed ID: 17177211
UVA irradiation induces relocalisation of the DNA repair protein hOGG1 to nuclear speckles.
Campalans A, Amouroux R, Bravard A, Epe B, Radicella JP
J Cell Sci. 2007
PubMed ID: 17148573
Femoral artery neointimal hyperplasia is reduced after wire injury in Ref-1+/- mice.
Basi DL, Adhikari N, Mariash A, Li Q, Kao E, Mullegama SV, Hall JL
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 16936011
Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers.
Ryk C, Kumar R, Thirumaran RK, Hou SM
Lung Cancer. 2006
PubMed ID: 17034901
Association of genetic polymorphisms in the base excision repair pathway with lung cancer risk: a meta-analysis.
Kiyohara C, Takayama K, Nakanishi Y
Lung Cancer. 2006
PubMed ID: 16982113
The protective effect of hepatocyte growth factor against cell death in the hippocampus after transient forebrain ischemia is related to the improvement of apurinic/apyrimidinic endonuclease/redox factor-1 level and inhibition of NADPH oxidase activity.
Niimura M, Takagi N, Takagi K, Mizutani R, Tanonaka K, Funakoshi H, Matsumoto K, Nakamura T, Takeo S
Neurosci Lett. 2006
PubMed ID: 16973282
Cooperative activity of Ref-1/APE and ERp57 in reductive activation of transcription factors.
Grillo C, D'Ambrosio C, Scaloni A, Maceroni M, Merluzzi S, Turano C, Altieri F
Free Radic Biol Med. 2006
PubMed ID: 16962936
Genetic variants of the ADPRT, XRCC1 and APE1 genes and risk of cutaneous melanoma.
Li C, Liu Z, Wang LE, Strom SS, Lee JE, Gershenwald JE, Ross MI, Mansfield PF, Cormier JN, Prieto VG, Duvic M, Grimm EA, Wei Q
Carcinogenesis. 2006
PubMed ID: 16621887
Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples.
Andreassen CN, Alsner J, Overgaard M, Sørensen FB, Overgaard J
Int J Radiat Biol. 2006
PubMed ID: 16966185
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochem Biophys Res Commun. 2006
PubMed ID: 16712791
[Relationship of genetic polymorphism in APE1 and ADPRT to risks of chronic benzene poisoning]
Sun P, Zhang ZB, Wan JX, Jin XP, Xia ZL
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006
PubMed ID: 16889694
APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.
Terry PD, Umbach DM, Taylor JA
Int J Cancer. 2006
PubMed ID: 16425270
Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity.
Jin Z, May WS, Gao F, Flagg T, Deng X
J Biol Chem. 2006
PubMed ID: 16554306
Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (gemcit
Lam W, Park SY, Leung CH, Cheng YC
Mol Pharmacol. 2006
PubMed ID: 16481390
Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer.
Moreno V, Gemignani F, Landi S, Gioia-Patricola L, Chabrier A, Blanco I, González S, Guino E, Capellà G, Canzian F
Clin Cancer Res. 2006
PubMed ID: 16609022
Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells.
Iwasaki K, Mackenzie EL, Hailemariam K, Sakamoto K, Tsuji Y
Mol Cell Biol. 2006
PubMed ID: 16537925
Efficiency of exonucleolytic action of apurinic/apyrimidinic endonuclease 1 towards matched and mismatched dNMP at the 3' terminus of different oligomeric DNA structures correlates with thermal stability of DNA duplexes.
Dyrkheeva NS, Lomzov AA, Pyshnyi DV, Khodyreva SN, Lavrik OI
Biochim Biophys Acta. 2006
PubMed ID: 16481227
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.
Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, Phillips DH, Canzian F, Haugen A
Carcinogenesis. 2006
PubMed ID: 16195237
Nucleotide sequence and DNA secondary structure, as well as replication protein A, modulate the single-stranded abasic endonuclease activity of APE1.
Fan J, Matsumoto Y, Wilson DM
J Biol Chem. 2006
PubMed ID: 16356936
Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer.
Zhang Y, Newcomb PA, Egan KM, Titus-Ernstoff L, Chanock S, Welch R, Brinton LA, Lissowska J, Bardin-Mikolajczak A, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M
Cancer Epidemiol Biomarkers Prev. 2006
PubMed ID: 16492928
Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.
Jiao L, Bondy ML, Hassan MM, Wolff RA, Evans DB, Abbruzzese JL, Li D
Cancer Detect Prev. 2006
PubMed ID: 16844323
Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells.
Chattopadhyay R, Wiederhold L, Szczesny B, Boldogh I, Hazra TK, Izumi T, Mitra S
Nucleic Acids Res. 2006
PubMed ID: 16617147
Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans.
Chen L, Ambrosone CB, Lee J, Sellers TA, Pow-Sang J, Park JY
J Urol. 2006
PubMed ID: 16406883
Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review.
Hung RJ, Hall J, Brennan P, Boffetta P
Am J Epidemiol. 2005
PubMed ID: 16221808
Genetic polymorphisms in XRCC1, APE1, ADPRT, XRCC2, and XRCC3 and risk of chronic benzene poisoning in a Chinese occupational population.
Zhang Z, Wan J, Jin X, Jin T, Shen H, Lu D, Xia Z
Cancer Epidemiol Biomarkers Prev. 2005
PubMed ID: 16284386
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients.
Chang-Claude J, Popanda O, Tan XL, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, Ambrosone CB
Clin Cancer Res. 2005
PubMed ID: 16000577
Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer.
Broberg K, Björk J, Paulsson K, Höglund M, Albin M
Carcinogenesis. 2005
PubMed ID: 15746160
Polymorphisms in DNA repair genes as risk factors for spina bifida and orofacial clefts.
Olshan AF, Shaw GM, Millikan RC, Laurent C, Finnell RH
Am J Med Genet A. 2005
PubMed ID: 15887293
Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity.
Seemann S, Hainaut P
Oncogene. 2005
PubMed ID: 15824742
Induction of DNA repair proteins, Ref-1 and XRCC1, in adult rat brain following kainic acid-induced seizures.
Quach N, Chan T, Lu TA, Schreiber SS, Tan Z
Brain Res. 2005
PubMed ID: 15854596
Two essential but distinct functions of the mammalian abasic endonuclease.
Izumi T, Brown DB, Naidu CV, Bhakat KK, Macinnes MA, Saito H, Chen DJ, Mitra S
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15824325
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer.
Andreassen CN, Alsner J, Overgaard J, Herskind C, Haviland J, Owen R, Homewood J, Bliss J, Yarnold J
Radiother Oncol. 2005
PubMed ID: 15878096
The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress.
Vasko MR, Guo C, Kelley MR
DNA Repair (Amst). 2005
PubMed ID: 15661660
The intracellular localization of APE1/Ref-1: more than a passive phenomenon?
Tell G, Damante G, Caldwell D, Kelley MR
Antioxid Redox Signal. 2005
PubMed ID: 15706084
Redox factor 1 (Ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization.
Hanson S, Kim E, Deppert W
Oncogene. 2005
PubMed ID: 15674341
A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.
Fung H, Demple B
Mol Cell. 2005
PubMed ID: 15694346
Ape1 abasic endonuclease activity is regulated by magnesium and potassium concentrations and is robust on alternative DNA structures.
Wilson DM
J Mol Biol. 2005
PubMed ID: 15644200
Nucleolar proteome dynamics.
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M
Nature. 2005
PubMed ID: 15635413
Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.
Chang IY, Kim SH, Cho HJ, Lee DY, Kim MH, Chung MH, You HJ
Nucleic Acids Res. 2005
PubMed ID: 16147991
Analysis of nuclear transport signals in the human apurinic/apyrimidinic endonuclease (APE1/Ref1).
Jackson EB, Theriot CA, Chattopadhyay R, Mitra S, Izumi T
Nucleic Acids Res. 2005
PubMed ID: 15942031
APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.
Parsons JL, Dianova II, Dianov GL
Nucleic Acids Res. 2005
PubMed ID: 15831793
Polymorphisms in the DNA base excision repair genes APEX1 and XRCC1 and lung cancer risk in Xuan Wei, China.
Shen M, Berndt SI, Rothman N, Mumford JL, He X, Yeager M, Welch R, Chanock S, Keohavong P, Donahue M, Zheng T, Caporaso N, Lan Q
Anticancer Res. 2005
PubMed ID: 15816625
Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity.
Sukhanova MV, Khodyreva SN, Lebedeva NA, Prasad R, Wilson SH, Lavrik OI
Nucleic Acids Res. 2005
PubMed ID: 15731342
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ
Nat Biotechnol. 2005
PubMed ID: 15592455
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer.
Popanda O, Schattenberg T, Phong CT, Butkiewicz D, Risch A, Edler L, Kayser K, Dienemann H, Schulz V, Drings P, Bartsch H, Schmezer P
Carcinogenesis. 2004
PubMed ID: 15333465
Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1.
Hegde V, Wang M, Deutsch WA
Biochemistry. 2004
PubMed ID: 15518571
Novel role of tyrosine in catalysis by human AP endonuclease 1.
Mundle ST, Fattal MH, Melo LF, Coriolan JD, O'Regan NE, Strauss PR
DNA Repair (Amst). 2004
PubMed ID: 15380100
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.
Jeon BH, Gupta G, Park YC, Qi B, Haile A, Khanday FA, Liu YX, Kim JM, Ozaki M, White AR, Berkowitz DE, Irani K
Circ Res. 2004
PubMed ID: 15472121
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides.
Lau JP, Weatherdon KL, Skalski V, Hedley DW
Br J Cancer. 2004
PubMed ID: 15316562
Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells.
Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE
Gastroenterology. 2004
PubMed ID: 15362040
Spontaneous mutagenesis is enhanced in Apex heterozygous mice.
Huamani J, McMahan CA, Herbert DC, Reddick R, McCarrey JR, MacInnes MI, Chen DJ, Walter CA
Mol Cell Biol. 2004
PubMed ID: 15340075
Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk.
Ito H, Matsuo K, Hamajima N, Mitsudomi T, Sugiura T, Saito T, Yasue T, Lee KM, Kang D, Yoo KY, Sato S, Ueda R, Tajima K
Carcinogenesis. 2004
PubMed ID: 15044328
AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate.
Cistulli C, Lavrik OI, Prasad R, Hou E, Wilson SH
DNA Repair (Amst). 2004
PubMed ID: 15135726
Human apurinic endonuclease 1 (APE1) expression and prognostic significance in osteosarcoma: enhanced sensitivity of osteosarcoma to DNA damaging agents using silencing RNA APE1 expression inhibition.
Wang D, Luo M, Kelley MR
Mol Cancer Ther. 2004
PubMed ID: 15210853
Ref-1/Ape is critical for formation of the hypoxia-inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene.
Ziel KA, Campbell CC, Wilson GL, Gillespie MN
FASEB J. 2004
PubMed ID: 15084519
Human AP endonuclease (APE1) demonstrates endonucleolytic activity against AP sites in single-stranded DNA.
Marenstein DR, Wilson DM, Teebor GW
DNA Repair (Amst). 2004
PubMed ID: 15084314
Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair.
Raffoul JJ, Cabelof DC, Nakamura J, Meira LB, Friedberg EC, Heydari AR
J Biol Chem. 2004
PubMed ID: 14973123
Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.
Sigurdson AJ, Hauptmann M, Chatterjee N, Alexander BH, Doody MM, Rutter JL, Struewing JP
BMC Cancer. 2004
PubMed ID: 15113441
Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1.
Puppin C, Arturi F, Ferretti E, Russo D, Sacco R, Tell G, Damante G, Filetti S
Endocrinology. 2004
PubMed ID: 14630715
[Study on significance of single nucleotide polymorphisms in the redox domain of aprimidinic/apurinic endonuclease/redox factor-1 gene in Chinese sporadic colorectal cancer]
Tang XB, Hou J, Tan YS, Zhou HH, Liu J
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004
PubMed ID: 14767913
Effects of backbone contacts 3' to the abasic site on the cleavage and the product binding by human apurinic/apyrimidinic endonuclease (APE1).
Izumi T, Schein CH, Oezguen N, Feng Y, Braun W
Biochemistry. 2004
PubMed ID: 14730972
CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism.
Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C
J Biol Chem. 2004
PubMed ID: 14594818
Thermodynamic, kinetic and structural basis for recognition and repair of abasic sites in DNA by apurinic/apyrimidinic endonuclease from human placenta.
Beloglazova NG, Kirpota OO, Starostin KV, Ishchenko AA, Yamkovoy VI, Zharkov DO, Douglas KT, Nevinsky GA
Nucleic Acids Res. 2004
PubMed ID: 15459284
APE1 is the major 3'-phosphoglycolate activity in human cell extracts.
Parsons JL, Dianova II, Dianov GL
Nucleic Acids Res. 2004
PubMed ID: 15247342
MUTYH prevents OGG1 or APEX1 from inappropriately processing its substrate or reaction product with its C-terminal domain.
Tominaga Y, Ushijima Y, Tsuchimoto D, Mishima M, Shirakawa M, Hirano S, Sakumi K, Nakabeppu Y
Nucleic Acids Res. 2004
PubMed ID: 15199168
DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA.
Stuart JA, Hashiguchi K, Wilson DM, Copeland WC, Souza-Pinto NC, Bohr VA
Nucleic Acids Res. 2004
PubMed ID: 15107486
The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.
Gros L, Ishchenko AA, Ide H, Elder RH, Saparbaev MK
Nucleic Acids Res. 2004
PubMed ID: 14704345
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene.
Bhakat KK, Izumi T, Yang SH, Hazra TK, Mitra S
EMBO J. 2003
PubMed ID: 14633989
Mutations in the alpha8 loop of human APE1 alter binding and cleavage of DNA containing an abasic site.
Shen JC, Loeb LA
J Biol Chem. 2003
PubMed ID: 12966083
APE/Ref-1 and the mammalian response to genotoxic stress.
Fritz G, Grösch S, Tomicic M, Kaina B
Toxicology. 2003
PubMed ID: 14599768
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1.
Marsin S, Vidal AE, Sossou M, Ménissier-de Murcia J, Le Page F, Boiteux S, de Murcia G, Radicella JP
J Biol Chem. 2003
PubMed ID: 12933815
Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes.
Andreassen CN, Alsner J, Overgaard M, Overgaard J
Radiother Oncol. 2003
PubMed ID: 14643949
Human AP endonuclease possesses a significant activity as major 3'-5' exonuclease in human leukemia cells.
Yoshida A, Ueda T
Biochem Biophys Res Commun. 2003
PubMed ID: 14521941
Deferoxamine-induced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage.
Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G
Neurosurg Focus. 2003
PubMed ID: 15344903
Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance.
Freitas S, Moore DH, Michael H, Kelley MR
Clin Cancer Res. 2003
PubMed ID: 14581338
Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa.
Khomenko T, Deng X, Jadus MR, Szabo S
Biochem Biophys Res Commun. 2003
PubMed ID: 13679060
Human apurinic/apyrimidinic endonuclease (Ape1) and its N-terminal truncated form (AN34) are involved in DNA fragmentation during apoptosis.
Yoshida A, Urasaki Y, Waltham M, Bergman AC, Pourquier P, Rothwell DG, Inuzuka M, Weinstein JN, Ueda T, Appella E, Hickson ID, Pommier Y
J Biol Chem. 2003
PubMed ID: 12842873
Modulation of the 3'-->5'-exonuclease activity of human apurinic endonuclease (Ape1) by its 5'-incised Abasic DNA product.
Wong D, DeMott MS, Demple B
J Biol Chem. 2003
PubMed ID: 12857737
Oxidative stress stimulates IL-4 and IL-6 production in mast cells by an APE/Ref-1-dependent pathway.
Frossi B, De Carli M, Daniel KC, Rivera J, Pucillo C
Eur J Immunol. 2003
PubMed ID: 12884291
Brain expression of apurinic/apyrimidinic endonuclease (APE/Ref-1) multifunctional DNA repair enzyme gene in the mouse with special reference to the suprachiasmatic nucleus.
Kimura H, Dong X, Yagita K, Okamura H
Neurosci Res. 2003
PubMed ID: 12871766
Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells.
He T, Weintraub NL, Goswami PC, Chatterjee P, Flaherty DM, Domann FE, Oberley LW
Am J Physiol Heart Circ Physiol. 2003
PubMed ID: 12730053
Properties of and substrate determinants for the exonuclease activity of human apurinic endonuclease Ape1.
Wilson DM
J Mol Biol. 2003
PubMed ID: 12860125
Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis.
Bonner AE, Lemon WJ, You M
J Med Genet. 2003
PubMed ID: 12807961
Cysteine 64 of Ref-1 is not essential for redox regulation of AP-1 DNA binding.
Ordway JM, Eberhart D, Curran T
Mol Cell Biol. 2003
PubMed ID: 12773568
The exonuclease activity of human apurinic/apyrimidinic endonuclease (APE1). Biochemical properties and inhibition by the natural dinucleotide Gp4G.
Chou KM, Cheng YC
J Biol Chem. 2003
PubMed ID: 12624104
Modulation of glutathione and thioredoxin systems by calorie restriction during the aging process.
Cho CG, Kim HJ, Chung SW, Jung KJ, Shim KH, Yu BP, Yodoi J, Chung HY
Exp Gerontol. 2003
PubMed ID: 12742531
Ref-1 protein enhances the IL-2-stimulated telomerase activity.
Xu W, Yan M, Sun L, Zheng Z, Liu X
J Cell Biochem. 2003
PubMed ID: 12647295
Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity.
Marenstein DR, Chan MK, Altamirano A, Basu AK, Boorstein RJ, Cunningham RP, Teebor GW
J Biol Chem. 2003
PubMed ID: 12519758
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.
Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J
Cell. 2003
PubMed ID: 12628186
Specific stimulation of human apurinic/apyrimidinic endonuclease by heat shock protein 70.
Mendez F, Sandigursky M, Kureekattil RP, Kenny MK, Franklin WA, Bases R
DNA Repair (Amst). 2003
PubMed ID: 12547389
The DNA sequence and analysis of human chromosome 14.
Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Brüls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Ségurens B, Anière F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Ménard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufossé-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guérin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quétier F, Waterston R, Hood L, Weissenbach J
Nature. 2003
PubMed ID: 12508121
Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium.
Fuchs S, Philippe J, Corvol P, Pinet F
J Hypertens. 2003
PubMed ID: 12569263
Granzyme A: the road less traveled.
Pinkoski MJ, Green DR
Nat Immunol. 2003
PubMed ID: 12555094
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A.
Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J
Nat Immunol. 2003
PubMed ID: 12524539
AP endonuclease 1 has no biologically significant 3(')-->5(')-exonuclease activity.
Lebedeva NA, Khodyreva SN, Favre A, Lavrik OI
Biochem Biophys Res Commun. 2003
PubMed ID: 12480540
Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes.
Mathonnet G, Labuda D, Meloche C, Wambach T, Krajinovic M, Sinnett D
J Hum Genet. 2003
PubMed ID: 14625810
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line.
Frossi B, Tell G, Spessotto P, Colombatti A, Vitale G, Pucillo C
J Cell Physiol. 2002
PubMed ID: 12384995
AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.
Ranalli TA, Tom S, Bambara RA
J Biol Chem. 2002
PubMed ID: 12200445
Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8.
Cao X, Kambe F, Ohmori S, Seo H
Biochem Biophys Res Commun. 2002
PubMed ID: 12237116
The apurinic/apyrimidinic endonuclease activity of Ape1/Ref-1 contributes to human glioma cell resistance to alkylating agents and is elevated by oxidative stress.
Silber JR, Bobola MS, Blank A, Schoeler KD, Haroldson PD, Huynh MB, Kolstoe DD
Clin Cancer Res. 2002
PubMed ID: 12231548
APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.
Russo D, Celano M, Bulotta S, Bruno R, Arturi F, Giannasio P, Filetti S, Damante G, Tell G
Mol Cell Endocrinol. 2002
PubMed ID: 12242029
Identification of the functional elements in the bidirectional promoter of the mouse O-sialoglycoprotein endopeptidase and APEX nuclease genes.
Ikeda S, Ayabe H, Mori K, Seki Y, Seki S
Biochem Biophys Res Commun. 2002
PubMed ID: 12200116
Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors.
Orii A, Masutani H, Nikaido T, Zhai YL, Kato K, Kariya M, Konishi I, Yodoi J, Fujii S
J Clin Endocrinol Metab. 2002
PubMed ID: 12161506
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis.
Angkeow P, Deshpande SS, Qi B, Liu YX, Park YC, Jeon BH, Ozaki M, Irani K
Cell Death Differ. 2002
PubMed ID: 12058277
APE/Ref-1 is controlled by both redox and cAMP-dependent mechanisms in rat thyroid cells.
Tell G, Pines A, Pandolfi M, D'Elia AV, Donnini D, Lonigro R, Manzini G, Russo D, Di Loreto C, Damante G
Horm Metab Res. 2002
PubMed ID: 12173070
Polymorphisms in genes encoding drugs and xenobiotic metabolizing enzymes, DNA repair enzymes, and response to treatment of childhood acute lymphoblastic leukemia.
Krajinovic M, Labuda D, Mathonnet G, Labuda M, Moghrabi A, Champagne J, Sinnett D
Clin Cancer Res. 2002
PubMed ID: 11895912
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Tan Z, Sankar R, Tu W, Shin D, Liu H, Wasterlain CG, Schreiber SS
Brain Res. 2002
PubMed ID: 11852039
Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.
Hadi MZ, Ginalski K, Nguyen LH, Wilson DM
J Mol Biol. 2002
PubMed ID: 11866537
An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3' mispaired DNA.
Chou KM, Cheng YC
Nature. 2002
PubMed ID: 11832948
Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.
Kuninger DT, Izumi T, Papaconstantinou J, Mitra S
Nucleic Acids Res. 2002
PubMed ID: 11809897
DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis.
Shaikh AY, Martin LJ
Neuromolecular Med. 2002
PubMed ID: 12230304
Prognostic role of Ape/Ref-1 subcellular expression in stage I-III breast carcinomas.
Puglisi F, Barbone F, Tell G, Aprile G, Pertoldi B, Raiti C, Kelley MR, Damante G, Sobrero A, Beltrami CA, Di Loreto C
Oncol Rep. 2002
PubMed ID: 11748448
XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions.
Vidal AE, Boiteux S, Hickson ID, Radicella JP
EMBO J. 2001
PubMed ID: 11707423
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Bobola MS, Blank A, Berger MS, Stevens BA, Silber JR
Clin Cancer Res. 2001
PubMed ID: 11705870
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair.
Dianova II, Bohr VA, Dianov GL
Biochemistry. 2001
PubMed ID: 11601988
Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases.
Rodrigues-Lima F, Josephs M, Katan M, Cassinat B
Biochem Biophys Res Commun. 2001
PubMed ID: 11478795
Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress.
Meira LB, Devaraj S, Kisby GE, Burns DK, Daniel RL, Hammer RE, Grundy S, Jialal I, Friedberg EC
Cancer Res. 2001
PubMed ID: 11454706
Activation of APE/Ref-1 redox activity is mediated by reactive oxygen species and PKC phosphorylation.
Hsieh MM, Hegde V, Kelley MR, Deutsch WA
Nucleic Acids Res. 2001
PubMed ID: 11452037
Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas.
Thomson B, Tritt R, Davis M, Kelley MR
J Pediatr Hematol Oncol. 2001
PubMed ID: 11846302
Two divalent metal ions in the active site of a new crystal form of human apurinic/apyrimidinic endonuclease, Ape1: implications for the catalytic mechanism.
Beernink PT, Segelke BW, Hadi MZ, Erzberger JP, Wilson DM, Rupp B
J Mol Biol. 2001
PubMed ID: 11286553
Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.
Kelley MR, Cheng L, Foster R, Tritt R, Jiang J, Broshears J, Koch M
Clin Cancer Res. 2001
PubMed ID: 11309329
Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites.
Kenny MK, Mendez F, Sandigursky M, Kureekattil RP, Goldman JD, Franklin WA, Bases R
J Biol Chem. 2001
PubMed ID: 11133992
Human DNA polymerase beta initiates DNA synthesis during long-patch repair of reduced AP sites in DNA.
Podlutsky AJ, Dianova II, Podust VN, Bohr VA, Dianov GL
EMBO J. 2001
PubMed ID: 11250913
Mitochondrial localization of APE/Ref-1 in thyroid cells.
Tell G, Crivellato E, Pines A, Paron I, Pucillo C, Manzini G, Bandiera A, Kelley MR, Di Loreto C, Damante G
Mutat Res. 2001
PubMed ID: 11182545
Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair.
Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL
J Biol Chem. 2001
PubMed ID: 11092888
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Common polymorphisms and somatic mutations in human base excision repair genes in ovarian and endometrial cancers.
Pieretti M, Khattar NH, Smith SA
Mutat Res. 2001
PubMed ID: 11465542
Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation.
Wei SJ, Botero A, Hirota K, Bradbury CM, Markovina S, Laszlo A, Spitz DR, Goswami PC, Yodoi J, Gius D
Cancer Res. 2000
PubMed ID: 11118054
TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.
Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E
Mol Cell Biol. 2000
PubMed ID: 11073998
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Human APE/Ref-1 protein.
Fritz G
Int J Biochem Cell Biol. 2000
PubMed ID: 11084372
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Mol CD, Hosfield DJ, Tainer JA
Mutat Res. 2000
PubMed ID: 10946230
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Parikh SS, Walcher G, Jones GD, Slupphaug G, Krokan HE, Blackburn GM, Tainer JA
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10805771
Ultraviolet B radiation-induced skin cancer in mice defective in the Xpc, Trp53, and Apex (HAP1) genes: genotype-specific effects on cancer predisposition and pathology of tumors.
Cheo DL, Meira LB, Burns DK, Reis AM, Issac T, Friedberg EC
Cancer Res. 2000
PubMed ID: 10749126
Heat-shock proteins associated with base excision repair enzymes in HeLa cells.
Mendez F, Sandigursky M, Franklin WA, Kenny MK, Kureekattil R, Bases R
Radiat Res. 2000
PubMed ID: 10629618
DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]
Mol CD, Izumi T, Mitra S, Tainer JA
Nature. 2000
PubMed ID: 10667800
Ubiquitin Conjugating Enzyme Ubc9 is Involved in Protein Degradation of Redox Factor-1 (Ref-1).
Yan MD, Xu WJ, Lu LR, Sun LY, Liu XY, Zheng ZC
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shangh. 2000
PubMed ID: 12110916
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.
Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L
Mol Cell Biol. 2000
PubMed ID: 10594042
Thioredoxin-dependent redox regulation of p53-mediated p21 activation.
Ueno M, Masutani H, Arai RJ, Yamauchi A, Hirota K, Sakai T, Inamoto T, Yamaoka Y, Yodoi J, Nikaido T
J Biol Chem. 1999
PubMed ID: 10585464
Genomic structure of the rat major AP endonuclease gene (Apex) with an adjacent putative O-sialoglycoprotease gene (Prsmg1/Gcpl1) and a processed Apex pseudogene (Apexp1).
Yao M, Akiyama K, Tan Y, Sarker AH, Ikeda S, Alam SS, Tsutsui K, Yoshida MC, Seki S
Acta Med Okayama. 1999
PubMed ID: 10631378
Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins.
Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS
J Biol Chem. 1999
PubMed ID: 10559261
Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1.
Fritz G, Kaina B
Oncogene. 1999
PubMed ID: 10023679
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease.
Kakolyris S, Kaklamanis L, Giatromanolaki A, Koukourakis M, Hickson ID, Barzilay G, Turley H, Leek RD, Kanavaros P, Georgoulias V, Gatter KC, Harris AL
Histopathology. 1998
PubMed ID: 9870152
A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity.
Ludwig DL, MacInnes MA, Takiguchi Y, Purtymun PE, Henrie M, Flannery M, Meneses J, Pedersen RA, Chen DJ
Mutat Res. 1998
PubMed ID: 9806499
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
Ramana CV, Boldogh I, Izumi T, Mitra S
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9560228
Extension of conserved regions in the rat and mouse genomes by chromosomal assignments of 29 rat genes.
Cui Z, Yokoi N, Kuramoto T, Kitada K, Serikawa T
Exp Anim. 1998
PubMed ID: 9606417
Comparison of the promoters of the mouse (APEX) and human (APE) apurinic endonuclease genes.
Harrison L, Ascione AG, Takiguchi Y, Wilson DM, Chen DJ, Demple B
Mutat Res. 1997
PubMed ID: 9506886
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Engelender S, Sharp AH, Colomer V, Tokito MK, Lanahan A, Worley P, Holzbaur EL, Ross CA
Hum Mol Genet. 1997
PubMed ID: 9361024
The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.
Gorman MA, Morera S, Rothwell DG, de La Fortelle E, Mol CD, Tainer JA, Hickson ID, Freemont PS
EMBO J. 1997
PubMed ID: 9351835
Genetic interaction between HAP1/REF-1 and p53.
Meira LB, Cheo DL, Hammer RE, Burns DK, Reis A, Friedberg EC
Nat Genet. 1997
PubMed ID: 9326930
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
Bennett RA, Wilson DM, Wong D, Demple B
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207062
AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1.
Hirota K, Matsui M, Iwata S, Nishiyama A, Mori K, Yodoi J
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9108029
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
Identification of redox/repair protein Ref-1 as a potent activator of p53.
Jayaraman L, Murthy KG, Zhu C, Curran T, Xanthoudakis S, Prives C
Genes Dev. 1997
PubMed ID: 9119221
Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons.
Walton M, Lawlor P, Sirimanne E, Williams C, Gluckman P, Dragunow M
Brain Res Mol Brain Res. 1997
PubMed ID: 9030714
Negative regulation of the major human AP-endonuclease, a multifunctional protein.
Izumi T, Henner WD, Mitra S
Biochemistry. 1996
PubMed ID: 8942627
Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1.
Rothwell DG, Hickson ID
Nucleic Acids Res. 1996
PubMed ID: 8932375
The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.
Xanthoudakis S, Smeyne RJ, Wallace JD, Curran T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8799128
The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.
Chung U, Igarashi T, Nishishita T, Iwanari H, Iwamatsu A, Suwa A, Mimori T, Hata K, Ebisu S, Ogata E, Fujita T, Okazaki T
J Biol Chem. 1996
PubMed ID: 8621488
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
cDNA cloning of rat major AP endonuclease (APEX nuclease) and analyses of its mRNA expression in rat tissues.
Tan Y, Nakagawa Y, Akiyama K, Wakabayashi H, Sarker AH, Seki S
Acta Med Okayama. 1996
PubMed ID: 8701782
Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains.
Ono Y, Watanabe M, Inoue Y, Ohmoto T, Akiyama K, Tsutsui K, Seki S
Brain Res Dev Brain Res. 1995
PubMed ID: 7656403
Cloning, sequence analysis, and chromosomal assignment of the mouse Apex gene.
Akiyama K, Nagao K, Oshida T, Tsutsui K, Yoshida MC, Seki S
Genomics. 1995
PubMed ID: 7782087
A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium.
Okazaki T, Chung U, Nishishita T, Ebisu S, Usuda S, Mishiro S, Xanthoudakis S, Igarashi T, Ogata E
J Biol Chem. 1994
PubMed ID: 7961715
Genomic structure of the mouse apurinic/apyrimidinic endonuclease gene.
Takiguchi Y, Chen DJ
Mamm Genome. 1994
PubMed ID: 7533013
Structure, promoter analysis and chromosomal assignment of the human APEX gene.
Akiyama K, Seki S, Oshida T, Yoshida MC
Biochim Biophys Acta. 1994
PubMed ID: 8086453
Cloning of the multifunctional rat apurinic/apyrimidinic endonuclease (rAPEN)/redox factor from an immature T cell line.
Wilson TM, Carney JP, Kelley MR
Nucleic Acids Res. 1994
PubMed ID: 7510394
Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.
Walker LJ, Robson CN, Black E, Gillespie D, Hickson ID
Mol Cell Biol. 1993
PubMed ID: 8355688
Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12).
Harrison L, Ascione G, Menninger JC, Ward DC, Demple B
Hum Mol Genet. 1992
PubMed ID: 1284593
Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q 11.2-12.
Robson CN, Hochhauser D, Craig R, Rack K, Buckle VJ, Hickson ID
Nucleic Acids Res. 1992
PubMed ID: 1383925
Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.
Xanthoudakis S, Miao G, Wang F, Pan YC, Curran T
EMBO J. 1992
PubMed ID: 1380454
The human gene for apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12.
Zhao B, Grandy DK, Hagerup JM, Magenis RE, Smith L, Chauhan BC, Henner WD
Nucleic Acids Res. 1992
PubMed ID: 1380694
cDNA cloning, sequencing, expression and possible domain structure of human APEX nuclease homologous to Escherichia coli exonuclease III.
Seki S, Hatsushika M, Watanabe S, Akiyama K, Nagao K, Tsutsui K
Biochim Biophys Acta. 1992
PubMed ID: 1627644
Nucleotide sequence of a cDNA for an apurinic/apyrimidinic endonuclease from HeLa cells.
Cheng XB, Bunville J, Patterson TA
Nucleic Acids Res. 1992
PubMed ID: 1371347
Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.
Demple B, Herman T, Chen DS
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1722334
cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III.
Seki S, Akiyama K, Watanabe S, Hatsushika M, Ikeda S, Tsutsui K
J Biol Chem. 1991
PubMed ID: 1939131
Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.
Robson CN, Hickson ID
Nucleic Acids Res. 1991
PubMed ID: 1719477
A mouse DNA repair enzyme (APEX nuclease) having exonuclease and apurinic/apyrimidinic endonuclease activities: purification and characterization.
Seki S, Ikeda S, Watanabe S, Hatsushika M, Tsutsui K, Akiyama K, Zhang B
Biochim Biophys Acta. 1991
PubMed ID: 1716153

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	328	11792	79116
EnsEMBL Gene(s)	ENSG00000100823	ENSMUSG00000035960	ENSRNOG00000009663
Unigene	Hs.73722	Mm.203	Rn.5949
Homologene	APEX1	Apex1	Apex1
OMIM	107748	N/A	N/A
GeneCards	APEX1	N/A	N/A
Beta Cell Genomics	DT.100045339 DT.100840911 DT.100892406 DT.102837774 DT.117122 DT.450716 DT.91865427 DT.95340211 DT.97860983 DT.97860985	DT.101193190 DT.536624	N/A
Reactome	P27695	N/A	N/A
Plasma Peptide Atlas	ENSP00000216714	N/A	N/A
WikiGenes	328	11792	79116

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
APEX1	EIF1B	IntAct	empirical	17353931
APEX1	CSNK2A1	HPRD	empirical	10023679
APEX1	CTSB	Sanger Interaction Map	predicted	15345047
APEX1	DCTN1	HPRD	empirical	9361024
APEX1	EP300	HPRD, IntAct	empirical	14633989 20856196
APEX1	EPAS1	MIPS	empirical	1067148
APEX1	FEN1	HPRD, Reactome	empirical	11601988
APEX1	SIRT1	IntAct	empirical	19934257
APEX1	ANP32C	HPRD	empirical	12524539
APEX1	XRCC6	HPRD	empirical	8621488
APEX1	GZMA	HPRD	empirical	12524539 12555094
APEX1	HDAC1	HPRD	empirical	14633989
APEX1	HIF1A	HPRD	empirical	10594042
APEX1	HLA-B	IntAct	empirical	17353931
APEX1	HMGB2	HPRD	empirical	12524539
APEX1	HMGA1	IntAct	empirical	18850631
APEX1	HNRNPL	HPRD	empirical	11809897
APEX1	APEX1	HPRD	empirical	9108029
APEX1	HSPA1A	HPRD	empirical	11133992 10629618
APEX1	EIF6	IntAct	empirical	17353931
APEX1	ARF6	IntAct	empirical	17353931
APEX1	LIG1	Reactome	predicted
APEX1	MCC	IntAct	empirical	17353931
APEX1	MUTYH	HPRD	empirical	11092888
APEX1	NME1	HPRD	empirical	12524539
APEX1	YBX1	IntAct	empirical	20856196
APEX1	PAK2	IntAct	empirical	17353931
APEX1	PCNA	HPRD	empirical	11601988 10559261
APEX1	FAM82B	Sanger Interaction Map	predicted	15345047
APEX1	POLB	HPRD	empirical	9207062
APEX1	MAPK3	MINT	empirical	19935650
APEX1	NXF2	HPRD	empirical	11073998
APEX1	SET	HPRD	empirical	12628186 12524539
APEX1	TP53	HPRD	empirical	9119221
APEX1	TRAF6	IntAct	empirical	17353931
APEX1	TXN	HPRD	empirical	11118054 10585464 9108029
APEX1	UBE2I	HPRD	empirical	12110916
APEX1	XRCC1	HPRD, IntAct	empirical	11707423 19934257
APEX1	ANP32A	HPRD	empirical	12524539
APEX1	CCNA1	IntAct	empirical	17353931