HRAS

Summary Top Help

Gene Description:

Harvey rat sarcoma virus oncogene 1; Harvey rat sarcoma virus oncogene; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Synonyms:

c-Ha-ras, K-RAS, RASH1, HAMSV, Hras1, HRAS, C-HA-RAS1, H-ras, c-rasHa, Harvey-ras, N-RAS, C-BAS/HAS, c-H-ras, Ha-ras, CTLO, C-H-RAS, Hras, ras, Hras-1, H-RASIDX, Kras2, HRAS1

Orthologs:

Human HRAS (protein-coding), Mouse Hras1 (protein-coding), Rat Hras (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Not assigned	Mouse	chr7:117936155..152524553	34.59	508

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm10	Rat	chr1:178054386..201472944	23.42	321
Iddm25	Rat	chr1:193831373..230411453	36.58	585

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:532242..537287 (54 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:148375004..148379904 (4.90 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:201385705..201388987 (3.28 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for HRAS:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for HRAS:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 33

Biocarta: 55

Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	Human	Mouse
Aspirin Blocks Signaling Pathway Involved in Platelet Activation	Human
BCR Signaling Pathway	Human	Mouse
Bioactive Peptide Induced Signaling Pathway	Human	Mouse
Cadmium induces DNA synthesis and proliferation in macrophages	Human	Mouse
Calcium Signaling by HBx of Hepatitis B virus	Human	Mouse
CCR3 signaling in Eosinophils	Human	Mouse
CXCR4 Signaling Pathway	Human	Mouse
EGF Signaling Pathway	Human	Mouse
EPO Signaling Pathway	Human	Mouse
Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia	Human	Mouse
Erk1/Erk2 Mapk Signaling pathway	Human	Mouse
Fc Epsilon Receptor I Signaling in Mast Cells	Human	Mouse
fMLP induced chemokine gene expression in HMC-1 cells	Human	Mouse
Growth Hormone Signaling Pathway	Human	Mouse
How Progesterone Initiates the Oocyte Maturation	Human	Mouse
IGF-1 Signaling Pathway	Human	Mouse
IL 2 signaling pathway	Human	Mouse
IL 3 signaling pathway	Human	Mouse
IL 6 signaling pathway	Human	Mouse
IL-2 Receptor Beta Chain in T cell Activation	Human	Mouse
Influence of Ras and Rho proteins on G1 to S Transition	Human	Mouse
Inhibition of Cellular Proliferation by Gleevec	Human	Mouse
Inhibition of Matrix Metalloproteinases	Human	Mouse
Insulin Signaling Pathway	Human	Mouse
Integrin Signaling Pathway	Human	Mouse
Keratinocyte Differentiation	Human	Mouse
Links between Pyk2 and Map Kinases	Human	Mouse
MAPKinase Signaling Pathway	Human	Mouse
mCalpain and friends in Cell motility	Human	Mouse
METS affect on Macrophage Differentiation	Human	Mouse
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	Human	Mouse
Nerve growth factor pathway (NGF)	Human	Mouse
NFAT and Hypertrophy of the heart (Transcription in the broken heart)	Human	Mouse
p38 MAPK Signaling Pathway	Human	Mouse
PDGF Signaling Pathway	Human	Mouse
Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway	Human	Mouse
Ras Signaling Pathway	Human	Mouse
Regulation of Splicing through Sam68	Human	Mouse
Regulation of transcriptional activity by PML	Human	Mouse
Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy	Human	Mouse
Role of ERBB2 in Signal Transduction and Oncology	Human	Mouse
Role of Erk5 in Neuronal Survival	Human	Mouse
Role of MAL in Rho-Mediated Activation of SRF	Human	Mouse
Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling	Human	Mouse
Signaling of Hepatocyte Growth Factor Receptor	Human	Mouse
Signaling Pathway from G-Protein Families	Human	Mouse
Sprouty regulation of tyrosine kinase signals	Human	Mouse
T Cell Receptor Signaling Pathway	Human	Mouse
The IGF-1 Receptor and Longevity	Human	Mouse
TPO Signaling Pathway	Human	Mouse
Transcription factor CREB and its extracellular signals	Human	Mouse
Trefoil Factors Initiate Mucosal Healing	Human	Mouse
Trka Receptor Signaling Pathway	Human	Mouse
VEGF, Hypoxia, and Angiogenesis	Human

Reactome: 40

NCI-Nature Pathway Interaction Database: 37

Gene Ontology: 54

Golgi membrane	GO:0000139
MAPK cascade	GO:0000165
Nucleotide binding	GO:0000166
Activation of MAPKK activity	GO:0000186
Positive regulation of protein phosphorylation	GO:0001934
GTPase activity	GO:0003924
Protein binding	GO:0005515
GTP binding	GO:0005525
Membrane fraction	GO:0005624
Soluble fraction	GO:0005625
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Microsome	GO:0005792
Golgi apparatus	GO:0005794
Cytosol	GO:0005829
Plasma membrane	GO:0005886
Endocytosis	GO:0006897
Apoptotic process	GO:0006915
Chemotaxis	GO:0006935
Cell cycle arrest	GO:0007050
Signal transduction	GO:0007165
Cell surface receptor signaling pathway	GO:0007166
Epidermal growth factor receptor signaling pathway	GO:0007173
Small GTPase mediated signal transduction	GO:0007264
Ras protein signal transduction	GO:0007265
Synaptic transmission	GO:0007268
Axon guidance	GO:0007411
Blood coagulation	GO:0007596
Protein C-terminus binding	GO:0008022
Positive regulation of cell proliferation	GO:0008284
Negative regulation of cell proliferation	GO:0008285
Insulin receptor signaling pathway	GO:0008286
Visual learning	GO:0008542
Fibroblast growth factor receptor signaling pathway	GO:0008543
Induction of apoptosis by intracellular signals	GO:0008629
Organ morphogenesis	GO:0009887
Actin cytoskeleton organization	GO:0030036
Mitotic cell cycle G1/S transition checkpoint	GO:0031575
Regulation of synaptic transmission, GABAergic	GO:0032228
Positive regulation of Rac protein signal transduction	GO:0035022
Social behavior	GO:0035176
Positive regulation of MAPK cascade	GO:0043410
Negative regulation of neuron apoptosis	GO:0043524
Positive regulation of DNA replication	GO:0045740
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of JNK cascade	GO:0046330
Nerve growth factor receptor signaling pathway	GO:0048011
Regulation of long-term neuronal synaptic plasticity	GO:0048169
Perinuclear region of cytoplasm	GO:0048471
Positive regulation of epithelial cell proliferation	GO:0050679
Leukocyte migration	GO:0050900
Striated muscle cell differentiation	GO:0051146
Positive regulation of ERK1 and ERK2 cascade	GO:0070374
Cellular senescence	GO:0090398

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 747

H-Ras isoform modulates extracellular matrix synthesis, proliferation, and migration in fibroblasts.
Fuentes-Calvo I, Blázquez-Medela AM, Eleno N, Santos E, López-Novoa JM, Martínez-Salgado C
Am J Physiol Cell Physiol. 2012
PubMed ID: 22094331
MEK1/2 dual-specificity protein kinases: structure and regulation.
Roskoski R
Biochem Biophys Res Commun. 2012
PubMed ID: 22177953
Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.
Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, Watanabe S, Sakamoto H, Kumamoto K, Takenoshita S, Gotoh N, Mizuno H, Sarai A, Kawano S, Yamaguchi R, Miyano S, Yokota J
Cancer Res. 2012
PubMed ID: 22080568
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.
Na KY, Kim RM, Song EM, Lee JH, Lee J, Soh EY
J Surg Oncol. 2012
PubMed ID: 21826673
Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.
Schulten HJ, Al-Maghrabi J, Al-Ghamdi K, Salama S, Al-Muhayawi S, Chaudhary A, Hamour O, Abuzenadah A, Gari M, Al-Qahtani M
Anticancer Res. 2011
PubMed ID: 22199277
Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers.
Araki M, Shima F, Yoshikawa Y, Muraoka S, Ijiri Y, Nagahara Y, Shirono T, Kataoka T, Tamura A
J Biol Chem. 2011
PubMed ID: 21930707
Analysis of binding site hot spots on the surface of Ras GTPase.
Buhrman G, O'Connor C, Zerbe B, Kearney BM, Napoleon R, Kovrigina EA, Vajda S, Kozakov D, Kovrigin EL, Mattos C
J Mol Biol. 2011
PubMed ID: 21945529
HRAS mutants identified in Costello syndrome patients can induce cellular senescence: possible implications for the pathogenesis of Costello syndrome.
Niihori T, Aoki Y, Okamoto N, Kurosawa K, Ohashi H, Mizuno S, Kawame H, Inazawa J, Ohura T, Arai H, Nabatame S, Kikuchi K, Kuroki Y, Miura M, Tanaka T, Ohtake A, Omori I, Ihara K, Mabe H, Watanabe K, Niijima S, Okano E, Numabe H, Matsubara Y
J Hum Genet. 2011
PubMed ID: 21850009
Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras.
Eggers JP, Grandgenett PM, Collisson EC, Lewallen ME, Tremayne J, Singh PK, Swanson BJ, Andersen JM, Caffrey TC, High RR, Ouellette M, Hollingsworth MA
Clin Cancer Res. 2011
PubMed ID: 21825040
The enhanced host-cell permissiveness of human cytomegalovirus is mediated by the Ras signaling pathway.
Filippakis H, Dimitropoulou P, Eliopoulos AG, Spandidos DA, Sourvinos G
Biochim Biophys Acta. 2011
PubMed ID: 21782855
Low incidence of EGFR and HRAS mutations in cutaneous squamous cell carcinomas of a German cohort.
Mauerer A, Herschberger E, Dietmaier W, Landthaler M, Hafner C
Exp Dermatol. 2011
PubMed ID: 21771097
The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.
Banerjee P, Basu A, Datta D, Gasser M, Waaga-Gasser AM, Pal S
J Biol Chem. 2011
PubMed ID: 21808062
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
H-ras up-regulates expression of BNIP3.
Kalas W, Swiderek E, Rapak A, Kopij M, Rak J, Strzadala L
Anticancer Res. 2011
PubMed ID: 21868531
Molecular confirmation of HRAS p.G12S in siblings with Costello syndrome.
Gripp KW, Stabley DL, Geller PL, Hopkins E, Stevenson DA, Carey JC, Sol-Church K
Am J Med Genet A. 2011
PubMed ID: 21834037
H-Ras-specific upregulation of granulocyte colony-stimulating factor promotes human breast cell invasion via matrix metalloproteinase-2.
Park S, Kim ES, Noh DY, Hwang KT, Moon A
Cytokine. 2011
PubMed ID: 21524920
Three cases of rare salivary gland tumours: a molecular study of TP53, CDKN2A/ARF, RAS, BRAF, PTEN, MAPK2 and EGFR genes.
Falbo V, Floridia G, Censi F, Marra M, Foschini MP, Taruscio D
Oncol Rep. 2011
PubMed ID: 21503581
Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
Luwor RB, Lu Y, Li X, Liang K, Fan Z
Cancer Lett. 2011
PubMed ID: 21411223
Limited evidence supported the association of HRAS1 polymorphism with breast cancer risk.
Zhang X, Jia M
Breast Cancer Res Treat. 2011
PubMed ID: 21336946
K-ras mutations correlate with atypical cytology and elevated CEA levels in pancreatic cystic neoplasms.
Mertz H
Dig Dis Sci. 2011
PubMed ID: 21264513
Current evidence on the relationship between HRAS1 polymorphism and breast cancer risk: a meta-analysis.
Zhang C, Lv GQ, Yu XM, Gu YL, Li JP, Du LF, Zhou P
Breast Cancer Res Treat. 2011
PubMed ID: 21221763
Changes in expression of oncogenes and TP53 tumour suppressor gene as biomarkers in head and neck cancers.
Szanyi I, Bauer M, Gerlinger I, Járai T, Gobel G, Lujber L, Szabadi E, Fehér K, Émber A, Ember I, Kiss I
Eur Arch Otorhinolaryngol. 2011
PubMed ID: 21120662
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Steatosis induced by the accumulation of apolipoprotein A-I and elevated ROS levels in H-ras12V transgenic mice contributes to hepatic lesions.
Wang AG, Moon HB, Chae JI, Kim JM, Kim YE, Yu DY, Lee DS
Biochem Biophys Res Commun. 2011
PubMed ID: 21600874
Carcinosarcoma of the pancreas: a unique case with emphasis on metaplastic transformation and the presence of undifferentiated pleomorphic high-grade sarcoma.
Kim HS, Joo SH, Yang DM, Lee SH, Choi SH, Lim SJ
J Gastrointestin Liver Dis. 2011
PubMed ID: 21725518
H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity.
Iborra S, Soto M, Stark-Aroeira L, Castellano E, Alarcón B, Alonso C, Santos E, Fernández-Malavé E
Blood. 2011
PubMed ID: 21444916
Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration.
Yadav V, Denning MF
Mol Carcinog. 2011
PubMed ID: 21480388
RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage.
Park SH, Kim JJ, Chung JS, Lee SR, Lee GY, Kim HJ, Yoo YD
Biochem Biophys Res Commun. 2011
PubMed ID: 21473856
[Gene mutation (KRAS, BRAF, PIK3CA) and clinical benefit of anti-EGFR antibody].
Ueno T, Moriwaki T, Hyodo I
Nihon Rinsho. 2011
PubMed ID: 22214007
Phenotypic analysis of individuals with Costello syndrome due to HRAS p.G13C.
Gripp KW, Hopkins E, Sol-Church K, Stabley DL, Axelrad ME, Doyle D, Dobyns WB, Hudson C, Johnson J, Tenconi R, Graham GE, Sousa AB, Heller R, Piccione M, Corsello G, Herman GE, Tartaglia M, Lin AE
Am J Med Genet A. 2011
PubMed ID: 21438134
Regulation of GATA-3 expression during CD4 lineage differentiation.
Gimferrer I, Hu T, Simmons A, Wang C, Souabni A, Busslinger M, Bender TP, Hernandez-Hoyos G, Alberola-Ila J
J Immunol. 2011
PubMed ID: 21357543
Abnormal activation of Ras/Raf/MAPK and RhoA/ROCKII signalling pathways in eutopic endometrial stromal cells of patients with endometriosis.
Yotova IY, Quan P, Leditznig N, Beer U, Wenzl R, Tschugguel W
Hum Reprod. 2011
PubMed ID: 21303778
Involvement of H-Ras and reactive oxygen species in proinflammatory cytokine-induced matrix metalloproteinase-13 expression in human articular chondrocytes.
Ahmad R, Sylvester J, Ahmad M, Zafarullah M
Arch Biochem Biophys. 2011
PubMed ID: 21211511
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.
Koh MS, Moon A
Biochem Biophys Res Commun. 2011
PubMed ID: 21281602
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E
Genes Dev. 2011
PubMed ID: 21317241
Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
Yong HY, Hwang JS, Son H, Park HI, Oh ES, Kim HH, Kim do K, Choi WS, Lee BJ, Kim HR, Moon A
Neoplasia. 2011
PubMed ID: 21403836
Ras regulates interleukin-1β-induced HIF-1α transcriptional activity in glioblastoma.
Sharma V, Dixit D, Koul N, Mehta VS, Sen E
J Mol Med (Berl). 2011
PubMed ID: 20865400
The role of K-ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
Sahu RP, Batra S, Kandala PK, Brown TL, Srivastava SK
Cancer Chemother Pharmacol. 2011
PubMed ID: 20848283
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
Shin KH, Bae SD, Hong HS, Kim RH, Kang MK, Park NH
Biochem Biophys Res Commun. 2011
PubMed ID: 21167132
Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Franco AT, Malaguarnera R, Refetoff S, Liao XH, Lundsmith E, Kimura S, Pritchard C, Marais R, Davies TF, Weinstein LS, Chen M, Rosen N, Ghossein R, Knauf JA, Fagin JA
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21220306
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
Makrodouli E, Oikonomou E, Koc M, Andera L, Sasazuki T, Shirasawa S, Pintzas A
Mol Cancer. 2011
PubMed ID: 21943101
G4-DNA formation in the HRAS promoter and rational design of decoy oligonucleotides for cancer therapy.
Membrino A, Cogoi S, Pedersen EB, Xodo LE
PLoS One. 2011
PubMed ID: 21931711
The mitochondrial genome is a "genetic sanctuary" during the oncogenic process.
Seoane M, Mosquera-Miguel A, Gonzalez T, Fraga M, Salas A, Costoya JA
PLoS One. 2011
PubMed ID: 21858071
The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression.
Pan W, Issaq S, Zhang Y
PLoS One. 2011
PubMed ID: 21747916
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
The Ras/MAPK pathway is required for generation of iNKT cells.
Hu T, Gimferrer I, Simmons A, Wiest D, Alberola-Ila J
PLoS One. 2011
PubMed ID: 21572967
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
Wegman P, Ahlin C, Sorbe B
Int J Gynecol Cancer. 2011
PubMed ID: 21330833
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Conformational states of human rat sarcoma (Ras) protein complexed with its natural ligand GTP and their role for effector interaction and GTP hydrolysis.
Spoerner M, Hozsa C, Poetzl JA, Reiss K, Ganser P, Geyer M, Kalbitzer HR
J Biol Chem. 2010
PubMed ID: 20937837
Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman CE, Bronson R, Neel BG, Seidman JG, Kucherlapati R
J Clin Invest. 2010
PubMed ID: 21041952
Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.
de Launay D, Vreijling J, Hartkamp LM, Karpus ON, Abreu JR, van Maanen MA, Sanders ME, Grabiec AM, Hamann J, Ørum H, Vervoordeldonk MJ, Fluiter K, Tak PP, Reedquist KA
Am J Pathol. 2010
PubMed ID: 20971740
The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras.
Santibanez JF, Pérez-Gómez E, Fernandez-L A, Garrido-Martin EM, Carnero A, Malumbres M, Vary CP, Quintanilla M, Bernabéu C
Carcinogenesis. 2010
PubMed ID: 20884686
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Chen HC, Chen HJ, Khan MA, Rao ZZ, Wan XX, Tan B, Zhang DZ
Tumour Biol. 2010
PubMed ID: 21080251
Constitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex.
Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20937865
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Pandith AA, Shah Z, Rasool R, Dil-Afroze, Yousuf A, Parveen N, Wani S, Siddiqi M
Tumori. 2010
PubMed ID: 21388064
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Dempke WC, Heinemann V
Anticancer Res. 2010
PubMed ID: 21115922
p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior.
Ma Z, Liu Z, Wu RF, Terada LS
Oncogene. 2010
PubMed ID: 20676142
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
HRAS-mutated Spitz tumors: A subtype of Spitz tumors with distinct features.
van Engen-van Grunsven AC, van Dijk MC, Ruiter DJ, Klaasen A, Mooi WJ, Blokx WA
Am J Surg Pathol. 2010
PubMed ID: 20871217
Molecular, morphologic, and outcome analysis of thyroid carcinomas according to degree of extrathyroid extension.
Rivera M, Ricarte-Filho J, Tuttle RM, Ganly I, Shaha A, Knauf J, Fagin J, Ghossein R
Thyroid. 2010
PubMed ID: 20860430
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.
Jazwinski SM, Kim S, Dai J, Li L, Bi X, Jiang JC, Arnold J, Batzer MA, Walker JA, Welsh DA, Lefante CM, Volaufova J, Myers L, Su LJ, Hausman DB, Miceli MV, Ravussin E, Poon LW, Cherry KE, Welsch MA, Georgia Centenarian Study and the Louisiana Healthy Aging Study
Aging Cell. 2010
PubMed ID: 20569235
Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence.
Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X
Oncogene. 2010
PubMed ID: 20581871
The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.
Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI
Oncogene. 2010
PubMed ID: 20581865
Integrated genetic and epigenetic analysis of bladder cancer reveals an additive diagnostic value of FGFR3 mutations and hypermethylation events.
Serizawa RR, Ralfkiær U, Steven K, Lam GW, Schmiedel S, Schüz J, Hansen AB, Horn T, Guldberg P
Int J Cancer. 2010
PubMed ID: 20824703
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
Sun LN, Luan HL, Zang FL, Wang M, Dong N, Guo Y, Sun BC, Zhan ZL
Zhonghua Zhong Liu Za Zhi. 2010
PubMed ID: 21122380
Effect of Ha-rasval12 on nm23 expression, tumor formation and metastasis of the transformants, and immunomodulation in tumor-bearing mice.
Hsieh CC, Wu SY, Lan SH, Weng TY, Tsai Y, Liu HS
Anticancer Res. 2010
PubMed ID: 20944141
Label-free screening of drug-protein interactions by time-resolved Fourier transform infrared spectroscopic assays exemplified by Ras interactions.
Kötting C, Suveyzdis Y, Bojja RS, Metzler-Nolte N, Gerwert K
Appl Spectrosc. 2010
PubMed ID: 20828432
Cancer genes alterations and HPV infection in oral squamous cell carcinoma.
Popović B, Jekić B, Novaković I, Luković L, Konstantinović V, Babić M, Milasin J
Int J Oral Maxillofac Surg. 2010
PubMed ID: 20579853
Cooperativity of Cdk4R24C and Ras in melanoma development.
Chawla R, Procknow JA, Tantravahi RV, Khurana JS, Litvin J, Reddy EP
Cell Cycle. 2010
PubMed ID: 20703083
[Study on association between an H-RAS gene polymorphism and gastric cancer development].
Kwack KB, Song HJ, Pyun JA, Lee KJ, Cho SW
Korean J Gastroenterol. 2010
PubMed ID: 20729618
Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase.
Lee J, Choi KJ, Lim MJ, Hong F, Choi TG, Tak E, Lee S, Kim YJ, Chang SG, Cho JM, Ha J, Kim SS
Cell Res. 2010
PubMed ID: 20603646
Leukotriene B(4) BLT receptor signaling regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of Ras/Raf/ERK/p42 AUF1 pathway.
Zhai B, Yang H, Mancini A, He Q, Antoniou J, Di Battista JA
J Biol Chem. 2010
PubMed ID: 20489206
Structural basis for conformational dynamics of GTP-bound Ras protein.
Shima F, Ijiri Y, Muraoka S, Liao J, Ye M, Araki M, Matsumoto K, Yamamoto N, Sugimoto T, Yoshikawa Y, Kumasaka T, Yamamoto M, Tamura A, Kataoka T
J Biol Chem. 2010
PubMed ID: 20479006
Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K-ras and EGFR alterations.
Okada A, Shimmyo T, Hashimoto T, Kobayashi Y, Miyagi Y, Ishikawa Y, Nakagawa K, Hayashi J, Tsuchiya E
Cancer Sci. 2010
PubMed ID: 20491778
The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.
Hawken SJ, Greenwood CM, Hudson TJ, Kustra R, McLaughlin J, Yang Q, Zanke BW, Little J
Hum Genet. 2010
PubMed ID: 20437058
Neuronal Ras activation inhibits adult hippocampal progenitor cell division and impairs spatial short-term memory.
Manns M, Bichler Z, Leske O, Heumann R
Genes Brain Behav. 2010
PubMed ID: 20398060
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Kwon O, Jeong SJ, Kim SO, He L, Lee HG, Jang KL, Osada H, Jung M, Kim BY, Ahn JS
Carcinogenesis. 2010
PubMed ID: 20375073
Single-pattern convergence of K-ras mutation correlates with surgical indication of intraductal papillary mucinous neoplasms.
Mizuno O, Kawamoto H, Yamamoto N, Horiguchi S, Tsutsumi K, Fujii M, Kato H, Hirao K, Kurihara N, Ishida E, Ogawa T, Okada H, Yamamoto K
Pancreas. 2010
PubMed ID: 20173673
Induction of the apoptosis inhibitor ARC by Ras in human cancers.
Wu L, Nam YJ, Kung G, Crow MT, Kitsis RN
J Biol Chem. 2010
PubMed ID: 20392691
Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns.
Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin JA, Ghossein RA
Mod Pathol. 2010
PubMed ID: 20526288
[Correlation between ras gene and the resistance of nasopharyngeal carcinoma to cetuximab].
Zuo Q, Luo RC
Nan Fang Yi Ke Da Xue Xue Bao. 2010
PubMed ID: 20584693
Isolated unilateral vestibular schwannomas do not harbor HRAS mutations.
Smith MJ, Hadfield KD, Ramsden RT, Rutherford SA, King AT, Newman WG, Evans DG
Am J Med Genet A. 2010
PubMed ID: 20503341
Ras signalling regulates differentiation and UCP1 expression in models of brown adipogenesis.
Murholm M, Dixen K, Hansen JB
Biochim Biophys Acta. 2010
PubMed ID: 20307629
Oncogenic K-Ras turns death receptors into metastasis-promoting receptors in human and mouse colorectal cancer cells.
Hoogwater FJ, Nijkamp MW, Smakman N, Steller EJ, Emmink BL, Westendorp BF, Raats DA, Sprick MR, Schaefer U, Van Houdt WJ, De Bruijn MT, Schackmann RC, Derksen PW, Medema JP, Walczak H, Borel Rinkes IH, Kranenburg O
Gastroenterology. 2010
PubMed ID: 20188103
Absence of BRAF, NRAS, KRAS, HRAS mutations, and RET/PTC gene rearrangements distinguishes dominant nodules in Hashimoto thyroiditis from papillary thyroid carcinomas.
Sadow PM, Heinrich MC, Corless CL, Fletcher JA, Nosé V
Endocr Pathol. 2010
PubMed ID: 20012784
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
Amosenko FA, Korchagina EL, Matveeva TI, Vaganov IuE, Vlasov SB, Poltavets NV, Veselov VV, Gar'kavtseva RF, Poliakov AV
Genetika. 2010
PubMed ID: 20583607
Inactivation of the p53 tumor suppressor gene and activation of the Ras oncogene: cooperative events in tumorigenesis.
Solomon H, Brosh R, Buganim Y, Rotter V
Discov Med. 2010
PubMed ID: 20515613
High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities.
Gripp KW, Hopkins E, Doyle D, Dobyns WB
Am J Med Genet A. 2010
PubMed ID: 20425820
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Bassères DS, Ebbs A, Levantini E, Baldwin AS
Cancer Res. 2010
PubMed ID: 20406971
The c-Jun NH2-terminal kinase 2 plays a dominant role in human epidermal neoplasia.
Ke H, Harris R, Coloff JL, Jin JY, Leshin B, Miliani de Marval P, Tao S, Rathmell JC, Hall RP, Zhang JY
Cancer Res. 2010
PubMed ID: 20354187
Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications.
Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD
Hum Mol Genet. 2010
PubMed ID: 20067919
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.
Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M
EMBO J. 2010
PubMed ID: 20150892
H-, N- and Kras cooperatively regulate lymphatic vessel growth by modulating VEGFR3 expression in lymphatic endothelial cells in mice.
Ichise T, Yoshida N, Ichise H
Development. 2010
PubMed ID: 20179099
Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation.
Suda K, Tomizawa K, Mitsudomi T
Cancer Metastasis Rev. 2010
PubMed ID: 20108024
RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.
Shu FJ, Ramineni S, Hepler JR
Cell Signal. 2010
PubMed ID: 19878719
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
Smith G, Bounds R, Wolf H, Steele RJ, Carey FA, Wolf CR
Br J Cancer. 2010
PubMed ID: 20147967
Viral DNA detection and RAS mutations in actinic keratosis and nonmelanoma skin cancers.
Zaravinos A, Kanellou P, Spandidos DA
Br J Dermatol. 2010
PubMed ID: 19849697
Modeling the effect of the RB tumor suppressor on disease progression: dependence on oncogene network and cellular context.
Dean JL, McClendon AK, Stengel KR, Knudsen ES
Oncogene. 2010
PubMed ID: 19802012
RalA suppresses early stages of Ras-induced squamous cell carcinoma progression.
Sowalsky AG, Alt-Holland A, Shamis Y, Garlick JA, Feig LA
Oncogene. 2010
PubMed ID: 19802010
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
Hydbring P, Bahram F, Su Y, Tronnersjö S, Högstrand K, von der Lehr N, Sharifi HR, Lilischkis R, Hein N, Wu S, Vervoorts J, Henriksson M, Grandien A, Lüscher B, Larsson LG
Proc Natl Acad Sci U S A. 2010
PubMed ID: 19966300
FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.
Kompier LC, Lurkin I, van der Aa MN, van Rhijn BW, van der Kwast TH, Zwarthoff EC
PLoS One. 2010
PubMed ID: 21072204
Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination.
Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A
PLoS One. 2010
PubMed ID: 20805985
DNA mutational differences in cytological specimens from pancreatic cancer and cholangiocarcinoma.
Fasanella KE, Krasinskas A, Schoedel KE, Sasatomi E, Slivka A, Whitcomb DC, Sanders M, Nodit L, Raab S, McGrath KM, Ohori NP, Khalid A
Pancreatology. 2010
PubMed ID: 20720444
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
van Houdt WJ, de Bruijn MT, Emmink BL, Raats D, Hoogwater FJ, Borel Rinkes IH, Kranenburg O
Cell Oncol. 2010
PubMed ID: 20413844
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Yunxia Z, Jun C, Guanshan Z, Yachao L, Xueke Z, Jin L
BMC Med Genet. 2010
PubMed ID: 20184776
Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients.
Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T, Nakamura T, Toguchida J
Anticancer Res. 2010
PubMed ID: 20150643
Activated Ras alters lens and corneal development through induction of distinct downstream targets.
Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V
BMC Dev Biol. 2010
PubMed ID: 20105280
Analysis of k-ras nuclear expression in fibroblasts and mesangial cells.
Fuentes-Calvo I, Blázquez-Medela AM, Santos E, López-Novoa JM, Martínez-Salgado C
PLoS One. 2010
PubMed ID: 20090846
Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis.
Song R, Spera M, Garrett C, Yosypiv IV
Mech Dev. 2010
PubMed ID: 19961928
Predicting recurrence and progression of noninvasive papillary bladder cancer at initial presentation based on quantitative gene expression profiles.
Birkhahn M, Mitra AP, Williams AJ, Lam G, Ye W, Datar RH, Balic M, Groshen S, Steven KE, Cote RJ
Eur Urol. 2010
PubMed ID: 19762144
Social isolation in rats inhibits oxidative metabolism, decreases the content of mitochondrial K-Ras and activates mitochondrial hexokinase.
Zhuravliova E, Barbakadze T, Zaalishvili E, Chipashvili M, Koshoridze N, Mikeladze D
Behav Brain Res. 2009
PubMed ID: 19616040
Silencing of the Lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation.
Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M
Oncogene. 2009
PubMed ID: 19855428
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Navaraj A, Finnberg N, Dicker DT, Yang W, Matthew EM, El-Deiry WS
Cancer Biol Ther. 2009
PubMed ID: 20038817
Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation.
Laubach JP, Fu P, Jiang X, Salter KH, Potti A, Arcasoy MO
Exp Hematol. 2009
PubMed ID: 19815050
Targeted genomic disruption of H-ras and N-ras has no effect on early renal changes after unilateral ureteral ligation.
Grande MT, Arévalo M, Núñez A, Cannata-Andía JB, Santos E, López-Novoa JM
World J Urol. 2009
PubMed ID: 19288266
Interneuronal growth and expression of interneuronal markers in visual cortex of mice with transgenic activation of Ras.
Patz S, Colovic C, Wawro S, Lafenetre P, Leske O, Heumann R, Schönfelder S, Tomaschewski J, Räk A, Wahle P
Exp Brain Res. 2009
PubMed ID: 19139860
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors.
Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Meyts ER, Wilkie AO
Nat Genet. 2009
PubMed ID: 19855393
Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.
Catela Ivkovic T, Loncar B, Spaventi R, Kapitanovic S
Int J Oncol. 2009
PubMed ID: 19787272
Organophosphorous pesticides and estrogen induce transformation of breast cells affecting p53 and c-Ha-ras genes.
Calaf GM, Echiburu-Chau C, Roy D
Int J Oncol. 2009
PubMed ID: 19787260
Frequent and significant K-ras mutation in the pancreas, the bile duct, and the gallbladder in autoimmune pancreatitis.
Kamisawa T, Tsuruta K, Okamoto A, Horiguchi S, Hayashi Y, Yun X, Yamaguchi T, Sasaki T
Pancreas. 2009
PubMed ID: 19752775
RAS signaling dysregulation in human embryonal Rhabdomyosarcoma.
Martinelli S, McDowell HP, Vigne SD, Kokai G, Uccini S, Tartaglia M, Dominici C
Genes Chromosomes Cancer. 2009
PubMed ID: 19681119
Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis.
Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S
J Biol Chem. 2009
PubMed ID: 19700408
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
Cho YM, Imai T, Hasumura M, Watanabe N, Ushijima T, Hirose M, Nishikawa A
J Toxicol Sci. 2009
PubMed ID: 19652463
Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.
Murugan AK, Hong NT, Cuc TT, Hung NC, Munirajan AK, Ikeda MA, Tsuchida N
Oral Oncol. 2009
PubMed ID: 19628422
Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death.
Byun JY, Kim MJ, Yoon CH, Cha H, Yoon G, Lee SJ
Mol Cancer Res. 2009
PubMed ID: 19723872
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE
Oncogene. 2009
PubMed ID: 19543317
Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells.
Takezawa K, Okamoto I, Yonesaka K, Hatashita E, Yamada Y, Fukuoka M, Nakagawa K
Cancer Res. 2009
PubMed ID: 19638574
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases.
Sacco F, Tinti M, Palma A, Ferrari E, Nardozza AP, Hooft van Huijsduijnen R, Takahashi T, Castagnoli L, Cesareni G
J Biol Chem. 2009
PubMed ID: 19494114
BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance.
Da Forno PD, Pringle JH, Fletcher A, Bamford M, Su L, Potter L, Saldanha G
Br J Dermatol. 2009
PubMed ID: 19438459
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z
Mol Cell. 2009
PubMed ID: 19595712
Dominance of EGFR and insignificant KRAS mutations in prediction of tyrosine-kinase therapy for NSCLC patients stratified by tumor subtype and smoking status.
Pesek M, Benesova L, Belsanova B, Mukensnabl P, Bruha F, Minarik M
Anticancer Res. 2009
PubMed ID: 19596959
Chronic NF-kappaB activation delays RasV12-induced premature senescence of human fibroblasts by suppressing the DNA damage checkpoint response.
Batsi C, Markopoulou S, Vartholomatos G, Georgiou I, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E
Mech Ageing Dev. 2009
PubMed ID: 19406145
Follow-up study of K-ras mutations in the plasma of patients with pancreatic cancer: correlation with clinical features and carbohydrate antigen 19-9.
Däbritz J, Preston R, Hänfler J, Oettle H
Pancreas. 2009
PubMed ID: 19295453
The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.
Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ
PLoS Genet. 2009
PubMed ID: 19521500
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1.
Ricarte-Filho JC, Ryder M, Chitale DA, Rivera M, Heguy A, Ladanyi M, Janakiraman M, Solit D, Knauf JA, Tuttle RM, Ghossein RA, Fagin JA
Cancer Res. 2009
PubMed ID: 19487299
Constitutively enhanced p21Ras activity amplifies dendritic remodeling of hippocampal neurons during physical activity.
Alpár A, Naumann N, Arendt T, Gärtner U
Int J Dev Neurosci. 2009
PubMed ID: 19460636
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Crous-Bou M, Porta M, López T, Jariod M, Malats N, Morales E, Guarner L, Rifà J, Carrato A, Real FX, PANKRAS II Study Group
Environ Mol Mutagen. 2009
PubMed ID: 19326463
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Narumiya S, Tanji M, Ishizaki T
Cancer Metastasis Rev. 2009
PubMed ID: 19160018
p53, secreted by K-Ras-Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker.
Lee SH, Lee SJ, Chung JY, Jung YS, Choi SY, Hwang SH, Choi D, Ha NC, Park BJ
Oncogene. 2009
PubMed ID: 19347028
Endogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogene.
Chen X, Mitsutake N, LaPerle K, Akeno N, Zanzonico P, Longo VA, Mitsutake S, Kimura ET, Geiger H, Santos E, Wendel HG, Franco A, Knauf JA, Fagin JA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19416908
PI3K/Akt pathway mutations in Retinoblastoma.
Cohen Y, Merhavi-Shoham E, Avraham-Lubin BC, Savetsky M, Frenkel S, Pe'er J, Goldenberg-Cohen N
Invest Ophthalmol Vis Sci. 2009
PubMed ID: 19420344
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Mutation status of K-ras, p53 and allelic losses at 9p and 18q are not prognostic markers in patients with pancreatic cancer.
Salek C, Minarikova P, Benesova L, Nosek V, Strnad R, Zavoral M, Minarik M
Anticancer Res. 2009
PubMed ID: 19443408
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
De Oliveira Duarte Achcar R, Nikiforova MN, Yousem SA
Am J Clin Pathol. 2009
PubMed ID: 19369630
Activation of RAS family genes in urothelial carcinoma.
Boulalas I, Zaravinos A, Karyotis I, Delakas D, Spandidos DA
J Urol. 2009
PubMed ID: 19303097
Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation.
Vairaktaris E, Goutzanis L, Yapijakis C, Vassiliou S, Spyridonidou S, Vylliotis A, Nkenke E, Lazaris AC, Strantzias P, Patsouris E
Histol Histopathol. 2009
PubMed ID: 19283661
Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
Wilder PJ, Chakravarthy H, Hollingsworth MA, Rizzino A
Biochem Biophys Res Commun. 2009
PubMed ID: 19254697
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH
Cancer Res. 2009
PubMed ID: 19351817
BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation.
Imamura Y, Oda A, Katahira T, Bundo K, Pike KA, Ratcliffe MJ, Kitamura D
J Biol Chem. 2009
PubMed ID: 19218240
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Sartori G, Cavazza A, Sgambato A, Marchioni A, Barbieri F, Longo L, Bavieri M, Murer B, Meschiari E, Tamberi S, Cadioli A, Luppi F, Migaldi M, Rossi G
Am J Clin Pathol. 2009
PubMed ID: 19289583
PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1.
Xia S, Chen Z, Forman LW, Faller DV
Cell Signal. 2009
PubMed ID: 19146951
Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes.
Espada J, Galaz S, Sanz-Rodríguez F, Blázquez-Castro A, Stockert JC, Bagazgoitia L, Jaén P, González S, Cano A, Juarranz A
J Cell Physiol. 2009
PubMed ID: 19065634
H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation.
Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY
J Cell Sci. 2009
PubMed ID: 19240121
Regulation and function of neuronal GTP-Ras in facial motor nerve regeneration.
Makwana M, Serchov T, Hristova M, Bohatschek M, Gschwendtner A, Kalla R, Liu Z, Heumann R, Raivich G
J Neurochem. 2009
PubMed ID: 19284475
Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer.
Schittenhelm MM, Kollmannsberger C, Oechsle K, Harlow A, Morich J, Honecker F, Kurek R, Störkel S, Kanz L, Corless CL, Wong KK, Bokemeyer C, Heinrich MC
Mol Cancer Ther. 2009
PubMed ID: 19276157
Male-to-male transmission of Costello syndrome: G12S HRAS germline mutation inherited from a father with somatic mosaicism.
Sol-Church K, Stabley DL, Demmer LA, Agbulos A, Lin AE, Smoot L, Nicholson L, Gripp KW
Am J Med Genet A. 2009
PubMed ID: 19206176
Ha-ras oncogene-induced Stat3 phosphorylation enhances oncogenicity of the cell.
Yeh HH, Giri R, Chang TY, Chou CY, Su WC, Liu HS
DNA Cell Biol. 2009
PubMed ID: 19182994
Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.
Casar B, Arozarena I, Sanz-Moreno V, Pinto A, Agudo-Ibáñez L, Marais R, Lewis RE, Berciano MT, Crespo P
Mol Cell Biol. 2009
PubMed ID: 19114553
NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.
Huang CC, Chien WP, Wong RH, Cheng YW, Chen MC, Lee H
Environ Mol Mutagen. 2009
PubMed ID: 19107910
Oncogenic HRAS mutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome.
Rosenberger G, Meien S, Kutsche K
Hum Mutat. 2009
PubMed ID: 19035362
High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.
Tyner JW, Erickson H, Deininger MW, Willis SG, Eide CA, Levine RL, Heinrich MC, Gattermann N, Gilliland DG, Druker BJ, Loriaux MM
Blood. 2009
PubMed ID: 19075190
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
Sui X, Shin S, Zhang R, Firozi PF, Yang L, Abbruzzese JL, Reddy SA
Oncogene. 2009
PubMed ID: 19029954
ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.
Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, Huber H, Csiszar A, Beug H, Mikulits W
Oncogene. 2009
PubMed ID: 19015638
Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development.
Azhar M, Runyan RB, Gard C, Sanford LP, Miller ML, Andringa A, Pawlowski S, Rajan S, Doetschman T
Dev Dyn. 2009
PubMed ID: 19161227
HTLV-1 Tax protein cooperates with Ras in protecting cells from apoptosis.
Vajente N, Trevisan R, Saggioro D
Apoptosis. 2009
PubMed ID: 19089619
The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation.
Van Kanegan MJ, Strack S
Mol Cell Biol. 2009
PubMed ID: 19029245
Germline expression of H-Ras(G12V) causes neurological deficits associated to Costello syndrome.
Viosca J, Schuhmacher AJ, Guerra C, Barco A
Genes Brain Behav. 2009
PubMed ID: 18823404
Cognitive profile of disorders associated with dysregulation of the RAS/MAPK signaling cascade.
Cesarini L, Alfieri P, Pantaleoni F, Vasta I, Cerutti M, Petrangeli V, Mariotti P, Leoni C, Ricci D, Vicari S, Selicorni A, Tartaglia M, Mercuri E, Zampino G
Am J Med Genet A. 2009
PubMed ID: 19133693
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
Malik NM, Gilroy DW, Kabouridis PS
FEBS Lett. 2009
PubMed ID: 19063885
P19 H-ras induces G1/S phase delay maintaining cells in a reversible quiescence state.
Camats M, Kokolo M, Heesom KJ, Ladomery M, Bach-Elias M
PLoS One. 2009
PubMed ID: 20046837
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
Wang T, Liu H, Chen Y, Liu W, Yu J, Wu G
J Exp Clin Cancer Res. 2009
PubMed ID: 20042089
H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents.
Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW
PLoS One. 2009
PubMed ID: 19936293
Serum-dependent transcriptional networks identify distinct functional roles for H-Ras and N-Ras during initial stages of the cell cycle.
Castellano E, Guerrero C, Núñez A, De Las Rivas J, Santos E
Genome Biol. 2009
PubMed ID: 19895680
Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy.
Meyer M, Rübsamen D, Slany R, Illmer T, Stabla K, Roth P, Stiewe T, Eilers M, Neubauer A
PLoS One. 2009
PubMed ID: 19890398
Analysis of candidate genes in occurrence and growth of colorectal adenomas.
Olschwang S, Vernerey D, Cottet V, Pariente A, Nalet B, Lafon J, Faivre J, Laurent-Puig P, Bonithon-Kopp C, Bonaiti-Pellié C
J Oncol. 2009
PubMed ID: 19888426
Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.
Kiel C, Serrano L
Sci Signal. 2009
PubMed ID: 19638615
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.
Willard FS, Willard MD, Kimple AJ, Soundararajan M, Oestreich EA, Li X, Sowa NA, Kimple RJ, Doyle DA, Der CJ, Zylka MJ, Snider WD, Siderovski DP
PLoS One. 2009
PubMed ID: 19319189
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Lee SH, Lee SJ, Jung YS, Xu Y, Kang HS, Ha NC, Park BJ
Neoplasia. 2009
PubMed ID: 19107228
Membrane binding of lipidated Ras peptides and proteins--the structural point of view.
Brunsveld L, Waldmann H, Huster D
Biochim Biophys Acta. 2009
PubMed ID: 18771652
LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase.
Bulat N, Waeber G, Widmann C
J Lipid Res. 2009
PubMed ID: 18757346
A cross-talk between oncogenic Ras and tumor suppressor PTEN through FAK Tyr861 phosphorylation in NIH/3T3 mouse embryonic fibroblasts.
Bahk YY, Cho IH, Kim TS
Biochem Biophys Res Commun. 2008
PubMed ID: 19000654
8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells.
Saxowsky TT, Meadows KL, Klungland A, Doetsch PW
Proc Natl Acad Sci U S A. 2008
PubMed ID: 19020090
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
Human protein factory for converting the transcriptome into an in vitro-expressed proteome,.
Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N
Nat Methods. 2008
PubMed ID: 19054851
Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells.
Li Q, Mattingly RR
Neoplasia. 2008
PubMed ID: 19048123
Secondary structure of lipidated Ras bound to a lipid bilayer.
Güldenhaupt J, Adigüzel Y, Kuhlmann J, Waldmann H, Kötting C, Gerwert K
FEBS J. 2008
PubMed ID: 19021766
Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes.
Farassati F, Pan W, Yamoutpour F, Henke S, Piedra M, Frahm S, Al-Tawil S, Mangrum WI, Parada LF, Rabkin SD, Martuza RL, Kurtz A
Am J Pathol. 2008
PubMed ID: 18988803
Pak1 regulates multiple c-Kit mediated Ras-MAPK gain-in-function phenotypes in Nf1+/- mast cells.
McDaniel AS, Allen JD, Park SJ, Jaffer ZM, Michels EG, Burgin SJ, Chen S, Bessler WK, Hofmann C, Ingram DA, Chernoff J, Clapp DW
Blood. 2008
PubMed ID: 18768391
Stimulation of Ebola virus production from persistent infection through activation of the Ras/MAPK pathway.
Strong JE, Wong G, Jones SE, Grolla A, Theriault S, Kobinger GP, Feldmann H
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18981410
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
Nemtsova MN, Pal'tseva EM, Babaian AIu, Mikhaĭlenko DS, Babenko OV, Samofalova OIu, Tsar'kov PV, Zaletaev DV
Mol Biol (Mosk). 2008
PubMed ID: 19140325
Binding of calcium ions to Ras promotes Ras guanine nucleotide exchange under emulated physiological conditions.
Liao JM, Mo ZY, Wu LJ, Chen J, Liang Y
Biochim Biophys Acta. 2008
PubMed ID: 18790720
C/EBPbeta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf).
Ewing SJ, Zhu S, Zhu F, House JS, Smart RC
Cell Death Differ. 2008
PubMed ID: 18636078
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: implication in the development of retinopathy.
Kanwar M, Kowluru RA
Microvasc Res. 2008
PubMed ID: 18514235
Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling.
Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO
Oncogene. 2008
PubMed ID: 18641685
Global gene expression profiling unveils S100A8/A9 as candidate markers in H-ras-mediated human breast epithelial cell invasion.
Moon A, Yong HY, Song JI, Cukovic D, Salagrama S, Kaplan D, Putt D, Kim H, Dombkowski A, Kim HR
Mol Cancer Res. 2008
PubMed ID: 18922970
A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.
Ren XY, Liang ZY, Shi XH, Liu TH
Cancer Biol Ther. 2008
PubMed ID: 18769120
Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.
Jin M, Matsumoto S, Dewa Y, Nishimura J, Saekusa Y, Hasumi K, Mitsumori K
Arch Toxicol. 2008
PubMed ID: 18465119
p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.
Czyzyk J, Chen HC, Bottomly K, Flavell RA
J Biol Chem. 2008
PubMed ID: 18577512
Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations.
Ren YX, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, Triche TJ, Shimada H, Anderson MJ
Cancer Res. 2008
PubMed ID: 18701482
p19(ras) amplifies p73beta-induced apoptosis through mitochondrial pathway.
Kim JW, Kim WH, Jeong MH, Jang SM, Song KH, Park SI, Song PI, Kang KH, Choi KH
Biochem Biophys Res Commun. 2008
PubMed ID: 18555006
NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression.
Komatsu D, Kato M, Nakayama J, Miyagawa S, Kamata T
Oncogene. 2008
PubMed ID: 18454179
Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.
Park Y, Kubo A, Komiya T, Coxon A, Beebe K, Neckers L, Meltzer PS, Kaye FJ
Cell Cycle. 2008
PubMed ID: 18677112
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Etienne-Grimaldi MC, Formento JL, Francoual M, François E, Formento P, Renée N, Laurent-Puig P, Chazal M, Benchimol D, Delpero JR, Letoublon C, Pezet D, Seitz JF, Milano G
Clin Cancer Res. 2008
PubMed ID: 18676755
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade.
Nojima H, Adachi M, Matsui T, Okawa K, Tsukita S, Tsukita S
Nat Cell Biol. 2008
PubMed ID: 18604197
P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
Mahdavinia M, Bishehsari F, Verginelli F, Cumashi A, Lattanzio R, Sotoudeh M, Ansari R, Semeraro D, Hormazdi M, Fakheri H, Rakhshani N, De Lellis L, Curia MC, Cama A, Piantelli M, Malekzadeh R, Iacobelli S, Mariani-Costantini R
J Cell Physiol. 2008
PubMed ID: 18330889
Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation.
Logunov DY, Scheblyakov DV, Zubkova OV, Shmarov MM, Rakovskaya IV, Gurova KV, Tararova ND, Burdelya LG, Naroditsky BS, Ginzburg AL, Gudkov AV
Oncogene. 2008
PubMed ID: 18408766
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.
Hu H, Qin Y, Bochorishvili G, Zhu Y, van Aelst L, Zhu JJ
J Neurosci. 2008
PubMed ID: 18667617
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.
Stieglitz B, Bee C, Schwarz D, Yildiz O, Moshnikova A, Khokhlatchev A, Herrmann C
EMBO J. 2008
PubMed ID: 18596699
Alphavirus production is inhibited in neurofibromin 1-deficient cells through activated RAS signalling.
Kolokoltsova OA, Domina AM, Kolokoltsov AA, Davey RA, Weaver SC, Watowich SJ
Virology. 2008
PubMed ID: 18485440
The spread of Ras activity triggered by activation of a single dendritic spine.
Harvey CD, Yasuda R, Zhong H, Svoboda K
Science. 2008
PubMed ID: 18556515
[Effect of microRNA143 expression on cell proliferation in colonic carcinoma]
Liu H, Zhang SZ, Cai SR, Peng JP, Zheng S
Zhonghua Zhong Liu Za Zhi. 2008
PubMed ID: 19062714
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.
Lu CW, Yabuuchi A, Chen L, Viswanathan S, Kim K, Daley GQ
Nat Genet. 2008
PubMed ID: 18536715
Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells.
Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN
J Cell Biol. 2008
PubMed ID: 18591425
H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors.
Serban D, Leng J, Cheresh D
Circ Res. 2008
PubMed ID: 18467631
Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice.
Alpár A, Naumann N, Härtig W, Arendt T, Gärtner U
Eur J Neurosci. 2008
PubMed ID: 18598255
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
Schuhmacher AJ, Guerra C, Sauzeau V, Cañamero M, Bustelo XR, Barbacid M
J Clin Invest. 2008
PubMed ID: 18483625
Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB.
Marampon F, Casimiro MC, Fu M, Powell MJ, Popov VM, Lindsay J, Zani BM, Ciccarelli C, Watanabe G, Lee RJ, Pestell RG
Mol Biol Cell. 2008
PubMed ID: 18367547
The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.
Liu Y, El-Naggar S, Clem B, Chesney J, Dean DC
Biochem J. 2008
PubMed ID: 18215118
Distinct functions of H-Ras and K-Ras in proliferation and survival of primary hepatocytes due to selective activation of ERK and PI3K.
Rosseland CM, Wierød L, Flinder LI, Oksvold MP, Skarpen E, Huitfeldt HS
J Cell Physiol. 2008
PubMed ID: 18163378
The nitric oxide-sensitive p21Ras-ERK pathway mediates S-nitrosoglutathione-induced apoptosis.
Tsujita M, Batista WL, Ogata FT, Stern A, Monteiro HP, Arai RJ
Biochem Biophys Res Commun. 2008
PubMed ID: 18325324
Partial functional overlap of the three ras genes in mouse embryonic development.
Nakamura K, Ichise H, Nakao K, Hatta T, Otani H, Sakagami H, Kondo H, Katsuki M
Oncogene. 2008
PubMed ID: 18059342
FAD24, a regulator of adipogenesis and DNA replication, inhibits H-RAS-mediated transformation by repressing NF-kappaB activity.
Johmura Y, Suzuki M, Osada S, Nishizuka M, Imagawa M
Biochem Biophys Res Commun. 2008
PubMed ID: 18284919
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Freeman DJ, Juan T, Reiner M, Hecht JR, Meropol NJ, Berlin J, Mitchell E, Sarosi I, Radinsky R, Amado RG
Clin Colorectal Cancer. 2008
PubMed ID: 18621636
Membrane-dependent signal integration by the Ras activator Son of sevenless.
Gureasko J, Galush WJ, Boykevisch S, Sondermann H, Bar-Sagi D, Groves JT, Kuriyan J
Nat Struct Mol Biol. 2008
PubMed ID: 18454158
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Fujiwara K, Enomoto T, Fujita M, Kanda T, Fujii S, Ito K, Wakasa K, Ishiko O, Ueda M, Yamaguchi S, Kimura T, Umesaki N
Oncol Rep. 2008
PubMed ID: 18425390
PIK3CA, HRAS and KRAS gene mutations in human penile cancer.
Andersson P, Kolaric A, Windahl T, Kirrander P, Söderkvist P, Karlsson MG
J Urol. 2008
PubMed ID: 18355852
Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc.
Sheng L, Cai F, Zhu Y, Pal A, Athanasiou M, Orrison B, Blair DG, Hughes SH, Coffin JM, Lewis AM, Peden K
Biologicals. 2008
PubMed ID: 18218323
Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells.
Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, Yuki K, Sasaoka T, Suda T, Katsuki M, Miyazono K, Miyazawa K
J Cell Biol. 2008
PubMed ID: 18391074
Cigarette smoking and KRAS oncogene mutations in sporadic colorectal cancer: results from the Netherlands Cohort Study.
Weijenberg MP, Aardening PW, de Kok TM, de Goeij AF, van den Brandt PA
Mutat Res. 2008
PubMed ID: 18296105
Costello syndrome associated with novel germline HRAS mutations: an attenuated phenotype?
Gripp KW, Innes AM, Axelrad ME, Gillan TL, Parboosingh JS, Davies C, Leonard NJ, Lapointe M, Doyle D, Catalano S, Nicholson L, Stabley DL, Sol-Church K
Am J Med Genet A. 2008
PubMed ID: 18247425
Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations.
Cavaco BM, Batista PF, Martins C, Banito A, do Rosário F, Limbert E, Sobrinho LG, Leite V
Endocr Relat Cancer. 2008
PubMed ID: 18310288
A unique platform for H-Ras signaling involving clathrin-independent endocytosis.
Porat-Shliom N, Kloog Y, Donaldson JG
Mol Biol Cell. 2008
PubMed ID: 18094044
Severe neonatal manifestations of Costello syndrome.
Lo IF, Brewer C, Shannon N, Shorto J, Tang B, Black G, Soo MT, Ng DK, Lam ST, Kerr B
J Med Genet. 2008
PubMed ID: 18039947
p204 protein is a novel modulator of ras activity.
Ding B, Lengyel P
J Biol Chem. 2008
PubMed ID: 18165224
[Effect of shRNA-mediated silence of H-ras gene on proliferation of human SACC-M cells].
Yu LJ, Wang J, Dong FS, Shi H, Li HX, Gu HT
Zhonghua Kou Qiang Yi Xue Za Zhi. 2008
PubMed ID: 18683737
Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.
Denayer E, Parret A, Chmara M, Schubbert S, Vogels A, Devriendt K, Frijns JP, Rybin V, de Ravel TJ, Shannon K, Cools J, Scheffzek K, Legius E
Hum Mutat. 2008
PubMed ID: 17979197
Nuclear exclusion of forkhead box O and Elk1 and activation of nuclear factor-kappaB are required for C2C12-RasV12C40 myoblast differentiation.
De Alvaro C, Nieto-Vazquez I, Rojas JM, Lorenzo M
Endocrinology. 2008
PubMed ID: 17962350
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
Lito P, Mets BD, Kleff S, O'Reilly S, Maher VM, McCormick JJ
J Biol Chem. 2008
PubMed ID: 18048363
Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.
Lee JS, Gil JE, Kim JH, Kim TK, Jin X, Oh SY, Sohn YW, Jeon HM, Park HJ, Park JW, Shin YJ, Chung YG, Lee JB, You S, Kim H
Biochem Biophys Res Commun. 2008
PubMed ID: 18021740
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary.
Nagahashi M, Ajioka Y, Lang I, Szentirmay Z, Kasler M, Nakadaira H, Yokoyama N, Watanabe G, Nishikura K, Wakai T, Shirai Y, Hatakeyama K, Yamamoto M
World J Gastroenterol. 2008
PubMed ID: 18176964
Mutations of RAS gene family in specimens of bladder cancer.
Karimianpour N, Mousavi-Shafaei P, Ziaee AA, Akbari MT, Pourmand G, Abedi A, Ahmadi A, Afshin Alavi H
Urol J. 2008
PubMed ID: 19101897
The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.
Labalette C, Nouët Y, Levillayer F, Armengol C, Renard CA, Soubigou G, Xia T, Buendia MA, Wei Y
PLoS ONE. 2008
PubMed ID: 19018287
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Zhang Y, Jin M, Liu B, Ma X, Yao K, Li Q, Chen K
BMC Cancer. 2008
PubMed ID: 18783589
Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?
Kristensen AT, Wiig JN, Larsen SG, Giercksky KE, Ekstrøm PO
BMC Cancer. 2008
PubMed ID: 18655729
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
Goutas N, Vlachodimitropoulos D, Bouka M, Lazaris AC, Nasioulas G, Gazouli M
Anticancer Res. 2008
PubMed ID: 18383861
Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
Schulz AL, Albrecht B, Arici C, van der Burgt I, Buske A, Gillessen-Kaesbach G, Heller R, Horn D, Hübner CA, Korenke GC, König R, Kress W, Krüger G, Meinecke P, Mücke J, Plecko B, Rossier E, Schinzel A, Schulze A, Seemanova E, Seidel H, Spranger S, Tuysuz B, Uhrig S, Wieczorek D, Kutsche K, Zenker M
Clin Genet. 2008
PubMed ID: 18042262
Oncogenic H-Ras V12 promotes anchorage-independent cytokinesis in human fibroblasts.
Thullberg M, Gad A, Le Guyader S, Strömblad S
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18077377
Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf.
Buhrman G, Wink G, Mattos C
Structure. 2007
PubMed ID: 18073111
Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway.
Ruocco A, Santillo M, Cicale M, Serù R, Cuda G, Anrather J, Iadecola C, Postiglione A, Avvedimento EV, Paternò R
Eur J Neurosci. 2007
PubMed ID: 18005061
Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis.
Lee S, Chari NS, Kim HW, Wang X, Roop DR, Cho SH, DiGiovanni J, McDonnell TJ
Mol Carcinog. 2007
PubMed ID: 17538944
NMDA receptor activation dephosphorylates AMPA receptor glutamate receptor 1 subunits at threonine 840.
Delgado JY, Coba M, Anderson CN, Thompson KR, Gray EE, Heusner CL, Martin KC, Grant SG, O'Dell TJ
J Neurosci. 2007
PubMed ID: 18045915
Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.
Huang J, Furuya A, Furuichi T
J Cell Biol. 2007
PubMed ID: 17984326
Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.
Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP
Cancer Res. 2007
PubMed ID: 17974970
Mutations and differential expression of the ras family genes in human nasal polyposis.
Zaravinos A, Bizakis J, Soufla G, Sourvinos G, Spandidos DA
Int J Oncol. 2007
PubMed ID: 17912430
H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.
Sathyan KM, Nalinakumari KR, Kannan S
Mod Pathol. 2007
PubMed ID: 17767136
Transcriptomal profiling of site-specific Ras signals.
Agudo-Ibáñez L, Núñez F, Calvo F, Berenjeno IM, Bustelo XR, Crespo P
Cell Signal. 2007
PubMed ID: 17714917
The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression.
Verykokakis M, Papadaki C, Vorgia E, Le Gallic L, Mavrothalassitis G
J Biol Chem. 2007
PubMed ID: 17699159
Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.
Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH
Cell Stem Cell. 2007
PubMed ID: 18371380
A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.
Depaux A, Regnier-Ricard F, Germani A, Varin-Blank N
Oncogene. 2007
PubMed ID: 17533377
Prevalence of RAS point mutations in papillary thyroid carcinoma; a novel mutation at codon 31 of K-RAS.
Cyniak-Magierska A, Brzeziańska E, Januszkiewicz-Caulier J, Jarzab B, Lewiński A
Exp Clin Endocrinol Diabetes. 2007
PubMed ID: 17943694
Ancestral bias in the Hras1 gene and distal Chromosome 7 among inbred mice.
Drew JC, Kastenmeier AS, Drinkwater NR
Mamm Genome. 2007
PubMed ID: 17906893
Effects of dietary calorie restriction or exercise on the PI3K and Ras signaling pathways in the skin of mice.
Xie L, Jiang Y, Ouyang P, Chen J, Doan H, Herndon B, Sylvester JE, Zhang K, Molteni A, Reichle M, Zhang R, Haub MD, Baybutt RC, Wang W
J Biol Chem. 2007
PubMed ID: 17646168
B- and C-RAF display essential differences in their binding to Ras: the isotype-specific N terminus of B-RAF facilitates Ras binding.
Fischer A, Hekman M, Kuhlmann J, Rubio I, Wiese S, Rapp UR
J Biol Chem. 2007
PubMed ID: 17635919
Serum components and activated Ha-ras antagonize expression of perivenous marker genes stimulated by beta-catenin signaling in mouse hepatocytes.
Braeuning A, Menzel M, Kleinschnitz EM, Harada N, Tamai Y, Köhle C, Buchmann A, Schwarz M
FEBS J. 2007
PubMed ID: 17697114
H-Ras does not need COP I- or COP II-dependent vesicular transport to reach the plasma membrane.
Zheng H, McKay J, Buss JE
J Biol Chem. 2007
PubMed ID: 17588947
Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts.
Kanno T, Takahashi T, Tsujisawa T, Ariyoshi W, Nishihara T
J Cell Biochem. 2007
PubMed ID: 17265428
BCR-tyrosine 177 plays an essential role in Ras and Akt activation and in human hematopoietic progenitor transformation in chronic myelogenous leukemia.
Chu S, Li L, Singh H, Bhatia R
Cancer Res. 2007
PubMed ID: 17638918
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice.
Ray D, Terao Y, Nimbalkar D, Hirai H, Osmundson EC, Zou X, Franks R, Christov K, Kiyokawa H
Cancer Res. 2007
PubMed ID: 17638870
Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS.
Tanaka T, Williams RL, Rabbitts TH
EMBO J. 2007
PubMed ID: 17568777
De novo HRAS and KRAS mutations in two siblings with short stature and neuro-cardio-facio-cutaneous features.
Søvik O, Schubbert S, Houge G, Steine SJ, Norgård G, Engelsen B, Njølstad PR, Shannon K, Molven A
J Med Genet. 2007
PubMed ID: 17601930
Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements.
Brandt S, Shafikhani S, Balachandran P, Jin S, Hartig R, König W, Engel J, Backert S
FEMS Immunol Med Microbiol. 2007
PubMed ID: 17428306
Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.
van der Burgt I, Kupsky W, Stassou S, Nadroo A, Barroso C, Diem A, Kratz CP, Dvorsky R, Ahmadian MR, Zenker M
J Med Genet. 2007
PubMed ID: 17412879
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.
Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J
Cell. 2007
PubMed ID: 17540175
Low prevalence of RAS-RAF-activating mutations in Spitz melanocytic nevi compared with other melanocytic lesions.
Indsto JO, Kumar S, Wang L, Crotty KA, Arbuckle SM, Mann GJ
J Cutan Pathol. 2007
PubMed ID: 17518771
Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells.
Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME
Endocrinology. 2007
PubMed ID: 17332061
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation.
Dai Y, Khanna P, Chen S, Pei XY, Dent P, Grant S
Blood. 2007
PubMed ID: 17264303
The role of PKC and PDK1 in monocyte lineage specification by Ras.
Pearn L, Fisher J, Burnett AK, Darley RL
Blood. 2007
PubMed ID: 17255356
Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis.
Nindl I, Gottschling M, Krawtchenko N, Lehmann MD, Röwert-Huber J, Eberle J, Stockfleth E, Forschner T
Br J Dermatol. 2007
PubMed ID: 17488404
Electrical properties of plasma membrane modulate subcellular distribution of K-Ras.
Gomez GA, Daniotti JL
FEBS J. 2007
PubMed ID: 17388810
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Kaul A, Overmeyer JH, Maltese WA
Cell Signal. 2007
PubMed ID: 17210246
RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus.
Tsai FM, Shyu RY, Jiang SY
Cell Signal. 2007
PubMed ID: 17196792
The tumor suppressor neurofibromin confers sensitivity to apoptosis by Ras-dependent and Ras-independent pathways.
Shapira S, Barkan B, Friedman E, Fridman E, Kloog Y, Stein R
Cell Death Differ. 2007
PubMed ID: 17096025
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.
Willard MD, Willard FS, Li X, Cappell SD, Snider WD, Siderovski DP
EMBO J. 2007
PubMed ID: 17380122
Further evidence for a somatic KRAS mutation in a pilocytic astrocytoma.
Janzarik WG, Kratz CP, Loges NT, Olbrich H, Klein C, Schäfer T, Scheurlen W, Roggendorf W, Weiller C, Niemeyer C, Korinthenberg R, Pfister S, Omran H
Neuropediatrics. 2007
PubMed ID: 17712732
Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones.
Chakrabarty K, Serchov T, Mann SA, Dietzel ID, Heumann R
Eur J Neurosci. 2007
PubMed ID: 17439485
H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.
de Godoy MA, Patel CA, Waldman SA, Katsuki M, Regan RF, Rattan S
Gastroenterology. 2007
PubMed ID: 17408635
The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells.
Obara Y, Horgan AM, Stork PJ
J Neurochem. 2007
PubMed ID: 17254020
p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways.
Shang X, Moon SY, Zheng Y
J Biol Chem. 2007
PubMed ID: 17272280
Distal phalangeal creases--a distinctive dysmorphic feature in disorders of the RAS signalling pathway?
Ørstavik KH, Tangeraas T, Molven A, Prescott TE
Eur J Med Genet. 2007
PubMed ID: 17324647
Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome.
Zampino G, Pantaleoni F, Carta C, Cobellis G, Vasta I, Neri C, Pogna EA, De Feo E, Delogu A, Sarkozy A, Atzeri F, Selicorni A, Rauen KA, Cytrynbaum CS, Weksberg R, Dallapiccola B, Ballabio A, Gelb BD, Neri G, Tartaglia M
Hum Mutat. 2007
PubMed ID: 17054105
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice.
Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A
Nature. 2007
PubMed ID: 17230190
Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome.
Kratz CP, Steinemann D, Niemeyer CM, Schlegelberger B, Koscielniak E, Kontny U, Zenker M
Hum Mol Genet. 2007
PubMed ID: 17164262
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T
Biochemistry. 2007
PubMed ID: 17260967
Hyperactivation of Ha-ras oncogene, but not Ink4a/Arf deficiency, triggers bladder tumorigenesis.
Mo L, Zheng X, Huang HY, Shapiro E, Lepor H, Cordon-Cardo C, Sun TT, Wu XR
J Clin Invest. 2007
PubMed ID: 17256055
The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.
de Gorter DJ, Vos JC, Pals ST, Spaargaren M
J Immunol. 2007
PubMed ID: 17237388
Mechanisms of guanosine triphosphate hydrolysis by Ras and Ras-GAP proteins as rationalized by ab initio QM/MM simulations.
Grigorenko BL, Nemukhin AV, Shadrina MS, Topol IA, Burt SK
Proteins. 2007
PubMed ID: 17094109
Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.
Zenker M, Lehmann K, Schulz AL, Barth H, Hansmann D, Koenig R, Korinthenberg R, Kreiss-Nachtsheim M, Meinecke P, Morlot S, Mundlos S, Quante AS, Raskin S, Schnabel D, Wehner LE, Kratz CP, Horn D, Kutsche K
J Med Genet. 2007
PubMed ID: 17056636
p73 cooperates with Ras in the activation of MAP kinase signaling cascade.
Fernandez-Garcia B, Vaqué JP, Herreros-Villanueva M, Marques-Garcia F, Castrillo F, Fernandez-Medarde A, León J, Marín MC
Cell Death Differ. 2007
PubMed ID: 16645632
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO
Nature. 2007
PubMed ID: 17230191
Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras.
Berger KL, Barriga F, Lace MJ, Turek LP, Zamba GJ, Domann FE, Lee JH, Klingelhutz AJ
Virology. 2006
PubMed ID: 16945398
[K-ras mutation analysis in ovarian serous borderline and malignant tumors]
Ma L, Guo LN, Liang ZY, Ren XY, Wu SF
Zhonghua Bing Li Xue Za Zhi. 2006
PubMed ID: 17374253
MIP-1alpha (CCL3) is a downstream target of FGFR3 and RAS-MAPK signaling in multiple myeloma.
Masih-Khan E, Trudel S, Heise C, Li Z, Paterson J, Nadeem V, Wei E, Roodman D, Claudio JO, Bergsagel PL, Stewart AK
Blood. 2006
PubMed ID: 16849642
Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
An HJ, Maeng O, Kang KH, Lee JO, Kim YS, Paik SG, Lee H
J Biol Chem. 2006
PubMed ID: 16954213
Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence.
Han YH, Kwon JH, Yu DY, Moon EY
Free Radic Res. 2006
PubMed ID: 17050172
Ras triggers acidosis-induced activation of the extracellular-signal-regulated kinase pathway in cardiac myocytes.
Haworth RS, Dashnyam S, Avkiran M
Biochem J. 2006
PubMed ID: 16831126
Somatic mosaicism for an HRAS mutation causes Costello syndrome.
Gripp KW, Stabley DL, Nicholson L, Hoffman JD, Sol-Church K
Am J Med Genet A. 2006
PubMed ID: 16969868
Ras signaling is essential for lens cell proliferation and lens growth during development.
Xie L, Overbeek PA, Reneker LW
Dev Biol. 2006
PubMed ID: 16889766
Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin.
Arora A, Kalra N, Shukla Y
Cancer Lett. 2006
PubMed ID: 16448747
Phospholipase C epsilon suppresses integrin activation.
Lad Y, McHugh B, Hodkinson PS, Mackinnon AC, Haslett C, Ginsberg MH, Sethi T
J Biol Chem. 2006
PubMed ID: 16895916
Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: relevance for the development of human breast cancer.
Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM, Pal S
Cancer Res. 2006
PubMed ID: 17018607
Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.
Nuñez Rodriguez N, Lee IN, Banno A, Qiao HF, Qiao RF, Yao Z, Hoang T, Kimmelman AC, Chan AM
Mol Cell Biol. 2006
PubMed ID: 16980617
Ras-dependent recruitment of c-Myc for transcriptional activation of nucleophosmin/B23 in highly malignant U1 bladder cancer cells.
Yeh CW, Huang SS, Lee RP, Yung BY
Mol Pharmacol. 2006
PubMed ID: 16857742
Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation.
Pimentel DR, Adachi T, Ido Y, Heibeck T, Jiang B, Lee Y, Melendez JA, Cohen RA, Colucci WS
J Mol Cell Cardiol. 2006
PubMed ID: 16806262
Recurring HRAS mutation G12S in Dutch patients with Costello syndrome.
van Steensel MA, Vreeburg M, Peels C, van Ravenswaaij-Arts CM, Bijlsma E, Schrander-Stumpel CT, van Geel M
Exp Dermatol. 2006
PubMed ID: 16881968
Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization.
Karbowniczek M, Robertson GP, Henske EP
J Biol Chem. 2006
PubMed ID: 16803888
Ligand-independent regulation of ErbB4 receptor phosphorylation by activated Ras.
Tal-Or P, Erlich S, Porat-Shliom N, Goldshmit Y, Ben-Baruch G, Shaharabani E, Kloog Y, Pinkas-Kramarski R
J Cell Biochem. 2006
PubMed ID: 16518842
Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.
Lund P, Weisshaupt K, Mikeska T, Jammas D, Chen X, Kuban RJ, Ungethüm U, Krapfenbauer U, Herzel HP, Schäfer R, Walter J, Sers C
Oncogene. 2006
PubMed ID: 16568090
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
Castro P, Soares P, Gusmão L, Seruca R, Sobrinho-Simões M
Oncogene. 2006
PubMed ID: 16532025
Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations.
Hiraoka S, Kato J, Tatsukawa M, Harada K, Fujita H, Morikawa T, Shiraha H, Shiratori Y
Gastroenterology. 2006
PubMed ID: 16890591
Zonal gene expression in murine liver: Are tumors helping us to solve the mystery?
Gebhardt R, Ueberham E
Hepatology. 2006
PubMed ID: 16871579
G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.
Abramova MV, Pospelova TV, Nikulenkov FP, Hollander CM, Fornace AJ, Pospelov VA
J Biol Chem. 2006
PubMed ID: 16717102
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, Nishina H
EMBO J. 2006
PubMed ID: 16810318
Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity.
Raines KW, Cao GL, Lee EK, Rosen GM, Shapiro P
Biochem J. 2006
PubMed ID: 16569214
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Ehmann F, Horn S, Garcia-Palma L, Wegner W, Fiedler W, Giehl K, Mayr GW, Jücker M
Leuk Lymphoma. 2006
PubMed ID: 16923573
Involvement of H- and N-Ras isoforms in transforming growth factor-beta1-induced proliferation and in collagen and fibronectin synthesis.
Martínez-Salgado C, Fuentes-Calvo I, García-Cenador B, Santos E, López-Novoa JM
Exp Cell Res. 2006
PubMed ID: 16624289
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).
Shiraishi K, Ascoli M
Endocrinology. 2006
PubMed ID: 16614081
Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia.
Auewarakul CU, Lauhakirti D, Tocharoentanaphol C
Eur J Haematol. 2006
PubMed ID: 16573741
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Sathyan KM, Nalinakumari KR, Abraham T, Kannan S
Oral Oncol. 2006
PubMed ID: 16488657
Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.
Bishehsari F, Mahdavinia M, Malekzadeh R, Verginelli F, Catalano T, Sotoudeh M, Bazan V, Agnese V, Esposito DL, De Lellis L, Semeraro D, Colucci G, Hormazdi M, Rakhshani N, Cama A, Piantelli M, Iacobelli S, Russo A, Mariani-Costantini R, Gruppo Oncologico dell'Italia Meridionale
Ann Oncol. 2006
PubMed ID: 16760302
Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells.
Li F, Munchhof AM, White HA, Mead LE, Krier TR, Fenoglio A, Chen S, Wu X, Cai S, Yang FC, Ingram DA
Hum Mol Genet. 2006
PubMed ID: 16644864
Incidence and prognostic impact of c-Kit, FLT3, and Ras gene mutations in core binding factor acute myeloid leukemia (CBF-AML).
Boissel N, Leroy H, Brethon B, Philippe N, de Botton S, Auvrignon A, Raffoux E, Leblanc T, Thomas X, Hermine O, Quesnel B, Baruchel A, Leverger G, Dombret H, Preudhomme C, Acute Leukemia French Association (ALFA), Leucémies Aiguës Myéloblastiques de l'Enfant (LAME) Cooperative Groups
Leukemia. 2006
PubMed ID: 16598313
Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome.
Chen CY, Lin LI, Tang JL, Tsay W, Chang HH, Yeh YC, Huang CF, Chiou RJ, Yao M, Ko BS, Chen YC, Lin KH, Lin DT, Tien HF
Leukemia. 2006
PubMed ID: 16598312
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.
Chen Y, Takita J, Hiwatari M, Igarashi T, Hanada R, Kikuchi A, Hongo T, Taki T, Ogasawara M, Shimada A, Hayashi Y
Genes Chromosomes Cancer. 2006
PubMed ID: 16518851
p19ras brings a new twist to the regulation of p73 by Mdm2.
Harms KL, Chen X
Sci STKE. 2006
PubMed ID: 16738062
Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm.
Liu Z, Li H, Derouet M, Berezkin A, Sasazuki T, Shirasawa S, Rosen K
J Biol Chem. 2006
PubMed ID: 16461771
Implications of NRAS mutations in AML: a study of 2502 patients.
Bacher U, Haferlach T, Schoch C, Kern W, Schnittger S
Blood. 2006
PubMed ID: 16434492
Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.
Kerr B, Delrue MA, Sigaudy S, Perveen R, Marche M, Burgelin I, Stef M, Tang B, Eden OB, O'Sullivan J, De Sandre-Giovannoli A, Reardon W, Brewer C, Bennett C, Quarell O, M'Cann E, Donnai D, Stewart F, Hennekam R, Cavé H, Verloes A, Philip N, Lacombe D, Levy N, Arveiler B, Black G
J Med Genet. 2006
PubMed ID: 16443854
Activating transcription factor 3, a stress-inducible gene, suppresses Ras-stimulated tumorigenesis.
Lu D, Wolfgang CD, Hai T
J Biol Chem. 2006
PubMed ID: 16469745
Expression of genes involved in the regulation of p16 in psoriatic involved skin.
Mark EB, Jonsson M, Asp J, Wennberg AM, Mölne L, Lindahl A
Arch Dermatol Res. 2006
PubMed ID: 16552541
H-Ras, R-Ras, and TC21 differentially regulate ureteric bud cell branching morphogenesis.
Pozzi A, Coffa S, Bulus N, Zhu W, Chen D, Chen X, Mernaugh G, Su Y, Cai S, Singh A, Brissova M, Zent R
Mol Biol Cell. 2006
PubMed ID: 16467383
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B
Mol Biol Cell. 2006
PubMed ID: 16436505
p19ras interacts with and activates p73 by involving the MDM2 protein.
Jeong MH, Bae J, Kim WH, Yoo SM, Kim JW, Song PI, Choi KH
J Biol Chem. 2006
PubMed ID: 16436381
Galphaq binds to p110alpha/p85alpha phosphoinositide 3-kinase and displaces Ras.
Ballou LM, Chattopadhyay M, Li Y, Scarlata S, Lin RZ
Biochem J. 2006
PubMed ID: 16268778
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Ruíz-Godoy R LM, Garcia-Cuellar CM, Herrera González NE, Suchil BL, Pérez-Cárdenas E, Sácnchez-Pérez Y, Suárez-Roa ML, Meneses A
J Exp Clin Cancer Res. 2006
PubMed ID: 16761621
Structure of a transient intermediate for GTP hydrolysis by ras.
Ford B, Hornak V, Kleinman H, Nassar N
Structure. 2006
PubMed ID: 16531227
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
Park KS, Jeon SH, Kim SE, Bahk YY, Holmen SL, Williams BO, Chung KC, Surh YJ, Choi KY
J Cell Sci. 2006
PubMed ID: 16478791
RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.
Mei FC, Young TW, Liu J, Cheng X
FASEB J. 2006
PubMed ID: 16384911
RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras.
Tsai FM, Shyu RY, Jiang SY
Cell Signal. 2006
PubMed ID: 16005186
The RAP1 guanine nucleotide exchange factor Epac2 couples cyclic AMP and Ras signals at the plasma membrane.
Li Y, Asuri S, Rebhun JF, Castro AF, Paranavitana NC, Quilliam LA
J Biol Chem. 2006
PubMed ID: 16316996
Prenylation is not necessary for endogenous Ras activation in non-malignant cells.
Khwaja A, Dockrell ME, Hendry BM, Sharpe CC
J Cell Biochem. 2006
PubMed ID: 16187291
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.
Dai P, Xiong WC, Mei L
J Biol Chem. 2006
PubMed ID: 16301319
Constitutive activation of ras in neurons: implications for the regulation of the mammalian circadian clock.
Serchov T, Heumann R
Chronobiol Int. 2006
PubMed ID: 16687293
Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.
Krizhanovsky V, Soreq L, Kliminski V, Ben-Arie N
J Mol Neurosci. 2006
PubMed ID: 16679559
HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.
Gripp KW, Lin AE, Stabley DL, Nicholson L, Scott CI, Doyle D, Aoki Y, Matsubara Y, Zackai EH, Lapunzina P, Gonzalez-Meneses A, Holbrook J, Agresta CA, Gonzalez IL, Sol-Church K
Am J Med Genet A. 2006
PubMed ID: 16329078
Identification by differential display of IL-24 autocrine loop activated by ras oncogenes.
Tan Z, Wang M, Liang P
Methods Mol Biol. 2006
PubMed ID: 16264231
Pure lipopolysaccharide or synthetic lipid A induces activation of p21Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K.
David MD, Cochrane CL, Duncan SK, Schrader JW
J Immunol. 2005
PubMed ID: 16339563
Enhanced erythropoiesis mediated by activation of the renin-angiotensin system via angiotensin II type 1a receptor.
Kato H, Ishida J, Imagawa S, Saito T, Suzuki N, Matsuoka T, Sugaya T, Tanimoto K, Yokoo T, Ohneda O, Sugiyama F, Yagami K, Fujita T, Yamamoto M, Nangaku M, Fukamizu A
FASEB J. 2005
PubMed ID: 16223784
Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance.
Lim KH, Counter CM
Cancer Cell. 2005
PubMed ID: 16286246
Ras-induced spreading and wound closure in human epidermal keratinocytes.
Tscharntke M, Pofahl R, Krieg T, Haase I
FASEB J. 2005
PubMed ID: 16170018
Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts.
Svegliati S, Cancello R, Sambo P, Luchetti M, Paroncini P, Orlandini G, Discepoli G, Paterno R, Santillo M, Cuozzo C, Cassano S, Avvedimento EV, Gabrielli A
J Biol Chem. 2005
PubMed ID: 16081426
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
Mukawa K, Fujii S, Takeda J, Kitajima K, Tominaga K, Chibana Y, Fujita M, Ichikawa K, Tomita S, Ono Y, Imura J, Kawamata H, Chiba T, Hiraishi H, Terano A, Fujimori T
J Gastroenterol Hepatol. 2005
PubMed ID: 16174078
Germline mutations in HRAS proto-oncogene cause Costello syndrome.
Aoki Y, Niihori T, Kawame H, Kurosawa K, Ohashi H, Tanaka Y, Filocamo M, Kato K, Suzuki Y, Kure S, Matsubara Y
Nat Genet. 2005
PubMed ID: 16170316
Proteomics analysis of H-RAS-mediated oncogenic transformation in a genetically defined human ovarian cancer model.
Young T, Mei F, Liu J, Bast RC, Kurosky A, Cheng X
Oncogene. 2005
PubMed ID: 15940260
DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.
Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME
J Biol Chem. 2005
PubMed ID: 16000296
Crosstalk between Pten and Ras signaling pathways in tumor development.
To MD, Perez-Losada J, Mao JH, Balmain A
Cell Cycle. 2005
PubMed ID: 16123588
Harvey-ras gene expression and epidermal cell proliferation in dibenzo[a,l]pyrene-treated early preneoplastic SENCAR mouse skin.
Khan GA, Bhattacharya G, Mailander PC, Meza JL, Hansen LA, Chakravarti D
J Invest Dermatol. 2005
PubMed ID: 16117800
Krüppel-like factor 5 promotes mitosis by activating the cyclin B1/Cdc2 complex during oncogenic Ras-mediated transformation.
Nandan MO, Chanchevalap S, Dalton WB, Yang VW
FEBS Lett. 2005
PubMed ID: 16102754
Human diploid fibroblasts are resistant to MEK/ERK-mediated disruption of the actin cytoskeleton and invasiveness stimulated by Ras.
Sukezane T, Oneyama C, Kakumoto K, Shibutani K, Hanafusa H, Akagi T
Oncogene. 2005
PubMed ID: 16007212
Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin.
Wang Y, Gao D, Atencio DP, Perez E, Saladi R, Moore J, Guevara D, Rosenstein BS, Lebwohl M, Wei H
Int J Cancer. 2005
PubMed ID: 15800929
E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.
Schmidt CR, Gi YJ, Patel TA, Coffey RJ, Beauchamp RD, Pearson AS
Surgery. 2005
PubMed ID: 16153441
DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.
Kelly PA, Rahmani Z
Mol Biol Cell. 2005
PubMed ID: 15917294
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
Calistri D, Rengucci C, Seymour I, Lattuneddu A, Polifemo AM, Monti F, Saragoni L, Amadori D
J Cell Physiol. 2005
PubMed ID: 15702478
Ras activity regulates cyclin E degradation by the Fbw7 pathway.
Minella AC, Welcker M, Clurman BE
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15980150
Microsatellite instability in sporadic and inherited colon adenocarcinomas from Greek patients: correlation with several clinicopathological characteristics.
Michalopoulos NV, Saetta AA, Lazaris AC, Gigelou F, Koilakou S, Patsouris E
Acta Gastroenterol Belg. 2005
PubMed ID: 16268414
Oncogenic Ras blocks transforming growth factor-beta-induced cell-cycle arrest by degradation of p27 through a MEK/Erk/SKP2-dependent pathway.
Schepers H, Wierenga AT, Eggen BJ, Vellenga E
Exp Hematol. 2005
PubMed ID: 15963850
Effects of HRAS oncogene on cell cycle progression in a cervical cancer-derived cell line.
Córdova-Alarcón E, Centeno F, Reyes-Esparza J, García-Carrancá A, Garrido E
Arch Med Res. 2005
PubMed ID: 15950068
Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.
Pruitt K, Ulkü AS, Frantz K, Rojas RJ, Muniz-Medina VM, Rangnekar VM, Der CJ, Shields JM
J Biol Chem. 2005
PubMed ID: 15831492
Cdc42 and Ras cooperate to mediate cellular transformation by intersectin-L.
Wang JB, Wu WJ, Cerione RA
J Biol Chem. 2005
PubMed ID: 15824104
Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.
Drosopoulos KG, Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, Pintzas A
J Biol Chem. 2005
PubMed ID: 15757891
Role of Ras/PKCzeta/MEK/ERK1/2 signaling pathway in angiotensin II-induced vascular smooth muscle cell proliferation.
Zhao Y, Liu J, Li L, Liu L, Wu L
Regul Pept. 2005
PubMed ID: 15721486
Role of epidermal growth factor receptor signaling in RAS-driven melanoma.
Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L
Mol Cell Biol. 2005
PubMed ID: 15870287
Single-molecule diffusion measurements of H-Ras at the plasma membrane of live cells reveal microdomain localization upon activation.
Lommerse PH, Snaar-Jagalska BE, Spaink HP, Schmidt T
J Cell Sci. 2005
PubMed ID: 15860728
Rheb binds and regulates the mTOR kinase.
Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J
Curr Biol. 2005
PubMed ID: 15854902
H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.
Shin I, Kim S, Song H, Kim HR, Moon A
J Biol Chem. 2005
PubMed ID: 15677464
Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors.
Lackner MR, Kindt RM, Carroll PM, Brown K, Cancilla MR, Chen C, de Silva H, Franke Y, Guan B, Heuer T, Hung T, Keegan K, Lee JM, Manne V, O'Brien C, Parry D, Perez-Villar JJ, Reddy RK, Xiao H, Zhan H, Cockett M, Plowman G, Fitzgerald K, Costa M, Ross-Macdonald P
Cancer Cell. 2005
PubMed ID: 15837622
Perturbation of epidermal growth factor receptor complex formation and Ras signalling in cells harbouring the hepatitis C virus subgenomic replicon.
Macdonald A, Chan JK, Harris M
J Gen Virol. 2005
PubMed ID: 15784896
Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
Parsons BL, Beland FA, Von Tungeln LS, Delongchamp RR, Fu PP, Heflich RH
Mol Carcinog. 2005
PubMed ID: 15761837
The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells.
Melillo RM, Castellone MD, Guarino V, De Falco V, Cirafici AM, Salvatore G, Caiazzo F, Basolo F, Giannini R, Kruhoffer M, Orntoft T, Fusco A, Santoro M
J Clin Invest. 2005
PubMed ID: 15761501
Superoxide anion radical modulates the activity of Ras and Ras-related GTPases by a radical-based mechanism similar to that of nitric oxide.
Heo J, Campbell SL
J Biol Chem. 2005
PubMed ID: 15684418
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT
Oncogene. 2005
PubMed ID: 15688026
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.
Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M, Kuhlmann J, Waldmann H, Wittinghofer A, Bastiaens PI
Science. 2005
PubMed ID: 15705808
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins.
Spoerner M, Nuehs A, Ganser P, Herrmann C, Wittinghofer A, Kalbitzer HR
Biochemistry. 2005
PubMed ID: 15697248
The p38 SAPK pathway is required for Ha-ras induced in vitro invasion of NIH3T3 cells.
Behren A, Binder K, Vucelic G, Herberhold S, Hirt B, Loewenheim H, Preyer S, Zenner HP, Simon C
Exp Cell Res. 2005
PubMed ID: 15652346
Small Jab1-containing subcomplex is regulated in an anchorage- and cell cycle-dependent manner, which is abrogated by ras transformation.
Fukumoto A, Tomoda K, Kubota M, Kato JY, Yoneda-Kato N
FEBS Lett. 2005
PubMed ID: 15710389
B-raf and Ha-ras mutations in chemically induced mouse liver tumors.
Jaworski M, Buchmann A, Bauer P, Riess O, Schwarz M
Oncogene. 2005
PubMed ID: 15592514
Regulation of Raf-1 by direct feedback phosphorylation.
Dougherty MK, Müller J, Ritt DA, Zhou M, Zhou XZ, Copeland TD, Conrads TP, Veenstra TD, Lu KP, Morrison DK
Mol Cell. 2005
PubMed ID: 15664191
The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis.
Mascaux C, Iannino N, Martin B, Paesmans M, Berghmans T, Dusart M, Haller A, Lothaire P, Meert AP, Noel S, Lafitte JJ, Sculier JP
Br J Cancer. 2005
PubMed ID: 15597105
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.
Vaqué JP, Navascues J, Shiio Y, Laiho M, Ajenjo N, Mauleon I, Matallanas D, Crespo P, León J
J Biol Chem. 2005
PubMed ID: 15528212
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Lüchtenborg M, Weijenberg MP, Wark PA, Saritas AM, Roemen GM, van Muijen GN, de Bruïne AP, van den Brandt PA, de Goeij AF
BMC Cancer. 2005
PubMed ID: 16356174
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Lambertini L, Surin K, Ton TV, Clayton N, Dunnick JK, Kim Y, Hong HH, Devereux TR, Sills RC
Toxicol Pathol. 2005
PubMed ID: 15902973
Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains.
Ozaki M, Ozaki K, Watanabe T, Uwagawa S, Okuno Y, Shirai T
Toxicol Pathol. 2005
PubMed ID: 15902970
Persistence of K-ras mutations in plasma after colorectal tumor resection.
Lindforss U, Zetterquist H, Papadogiannakis N, Olivecrona H
Anticancer Res. 2005
PubMed ID: 15816642
Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor.
Sreeramaneni R, Chaudhry A, McMahon M, Sherr CJ, Inoue K
Mol Cell Biol. 2005
PubMed ID: 15601844
Toll-like receptor 2 and mitogen- and stress-activated kinase 1 are effectors of Mycobacterium avium-induced cyclooxygenase-2 expression in macrophages.
Pathak SK, Bhattacharyya A, Pathak S, Basak C, Mandal D, Kundu M, Basu J
J Biol Chem. 2004
PubMed ID: 15496409
Identification of PSD-95 palmitoylating enzymes.
Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS
Neuron. 2004
PubMed ID: 15603741
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival.
Tarunina M, Alger L, Chu G, Munger K, Gudkov A, Jat PS
Mol Cell Biol. 2004
PubMed ID: 15572682
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Reid TS, Terry KL, Casey PJ, Beese LS
J Mol Biol. 2004
PubMed ID: 15451670
Activated H-Ras regulates hematopoietic cell survival by modulating Survivin.
Fukuda S, Pelus LM
Biochem Biophys Res Commun. 2004
PubMed ID: 15369798
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion.
Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA
Dev Cell. 2004
PubMed ID: 15469846
Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos.
Wang Y, Wang F, Sun T, Trostinskaia A, Wygle D, Puscheck E, Rappolee DA
Dev Dyn. 2004
PubMed ID: 15305288
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Liu RT, Hou CY, You HL, Huang CC, Hock-Liew, Chou FF, Wang PW, Cheng JT
Thyroid. 2004
PubMed ID: 15320975
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathways.
Kelly-Spratt KS, Gurley KE, Yasui Y, Kemp CJ
PLoS Biol. 2004
PubMed ID: 15314658
Change in protein flexibility upon complex formation: analysis of Ras-Raf using molecular dynamics and a molecular framework approach.
Gohlke H, Kuhn LA, Case DA
Proteins. 2004
PubMed ID: 15211515
Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts.
Lim Y, Han I, Jeon J, Park H, Bahk YY, Oh ES
J Biol Chem. 2004
PubMed ID: 15123632
The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase.
Flaxenburg JA, Melter M, Lapchak PH, Briscoe DM, Pal S
J Immunol. 2004
PubMed ID: 15187129
Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Arvanitakis M, Van Laethem JL, Parma J, De Maertelaer V, Delhaye M, Devière J
Endoscopy. 2004
PubMed ID: 15202051
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
Manenti G, Galbiati F, Giannì-Barrera R, Pettinicchio A, Acevedo A, Dragani TA
Oncogene. 2004
PubMed ID: 15064703
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP
J Biol Chem. 2004
PubMed ID: 15037605
Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.
Nomura K, Kanemura H, Satoh T, Kataoka T
J Biol Chem. 2004
PubMed ID: 15031297
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.
Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ
J Biol Chem. 2004
PubMed ID: 15031288
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Sanyal S, Festa F, Sakano S, Zhang Z, Steineck G, Norming U, Wijkström H, Larsson P, Kumar R, Hemminki K
Carcinogenesis. 2004
PubMed ID: 14688016
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats.
Kowluru RA, Kowluru A, Chakrabarti S, Khan Z
Diabetes. 2004
PubMed ID: 14988264
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer.
Mammas IN, Zafiropoulos A, Koumantakis E, Sifakis S, Spandidos DA
Gynecol Oncol. 2004
PubMed ID: 14984964
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma.
Shiratsuchi H, Hirakawa N, Saito T, Oda Y, Yamamoto H, Tomita K, Yamamoto T, Tsuneyoshi M
Oncol Rep. 2004
PubMed ID: 14767509
p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis.
Gao J, Huang HY, Pak J, Cheng J, Zhang ZT, Shapiro E, Pellicer A, Sun TT, Wu XR
Oncogene. 2004
PubMed ID: 14737103
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.
Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA
Nature. 2004
PubMed ID: 14724641
The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.
Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J
Oncogene. 2004
PubMed ID: 14724584
G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.
Weissman JT, Ma JN, Essex A, Gao Y, Burstein ES
Oncogene. 2004
PubMed ID: 14712229
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Okulczyk B, Kovalchuk O, Piotrowski Z, Myśliwiec P, Chyczewski L
Rocz Akad Med Bialymst. 2004
PubMed ID: 15638373
Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation.
Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA
Int J Dev Biol. 2004
PubMed ID: 15558479
[Study of HRas1 minisatellite frequencies in children with thyroid papillary cancer]
Iarmolinskiĭ DG, Kartel NA, Ermak G, Demidchik IuE, Figge J
Tsitol Genet. 2004
PubMed ID: 15098441
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.
Harada N, Oshima H, Katoh M, Tamai Y, Oshima M, Taketo MM
Cancer Res. 2004
PubMed ID: 14729607
SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway.
Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H
Oncogene. 2003
PubMed ID: 14654780
The HRAS1 variable number of tandem repeats and risk of breast cancer.
Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ
Cancer Epidemiol Biomarkers Prev. 2003
PubMed ID: 14693748
Lack of effect of human c-Ha-ras proto-oncogene overexpression on prostate carcinogenesis in probasin/SV40 T antigen transgenic rats.
Hokaiwado N, Asamoto M, Cho YM, Tsuda H, Shirai T
Cancer Sci. 2003
PubMed ID: 14662018
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system.
Zhang J, Socolovsky M, Gross AW, Lodish HF
Blood. 2003
PubMed ID: 12907435
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.
Mohney RP, Das M, Bivona TG, Hanes R, Adams AG, Philips MR, O'Bryan JP
J Biol Chem. 2003
PubMed ID: 12970366
The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1.
Krapivinsky G, Krapivinsky L, Manasian Y, Ivanov A, Tyzio R, Pellegrino C, Ben-Ari Y, Clapham DE, Medina I
Neuron. 2003
PubMed ID: 14622581
8-Hydroxyguanine in a mutational hotspot of the c-Ha-ras gene causes misreplication, 'action-at-a-distance' mutagenesis and inhibition of replication.
Jałoszyński P, Masutani C, Hanaoka F, Perez AB, Nishimura S
Nucleic Acids Res. 2003
PubMed ID: 14576295
Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages.
Xu H, An H, Yu Y, Zhang M, Qi R, Cao X
J Biol Chem. 2003
PubMed ID: 12867418
Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus.
Guil S, de La Iglesia N, Fernández-Larrea J, Cifuentes D, Ferrer JC, Guinovart JJ, Bach-Elias M
Cancer Res. 2003
PubMed ID: 14500341
Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.
Nagase H, Mao JH, Balmain A
Cancer Res. 2003
PubMed ID: 12941805
Ha-ras overexpression mediated cell apoptosis in the presence of 5-fluorouracil.
Tseng YS, Tzeng CC, Chiu AW, Lin CH, Won SJ, Wu IC, Liu HS
Exp Cell Res. 2003
PubMed ID: 12915131
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.
Fingerle-Rowson G, Petrenko O, Metz CN, Forsthuber TG, Mitchell R, Huss R, Moll U, Müller W, Bucala R
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12878730
Ha-ras oncogene mutation associated to progression of papillomavirus induced lesions of uterine cervix.
Alonio LV, Picconi MA, Dalbert D, Mural J, Bartt O, Bazán G, Dominguez M, Teyssié AR
J Clin Virol. 2003
PubMed ID: 12878090
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor.
Vos MD, Ellis CA, Elam C, Ulku AS, Taylor BJ, Clark GJ
J Biol Chem. 2003
PubMed ID: 12732644
rgr oncogene: activation by elimination of translational controls and mislocalization.
Hernández-Muñoz I, Benet M, Calero M, Jiménez M, Díaz R, Pellicer A
Cancer Res. 2003
PubMed ID: 12874025
Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission.
Imamura Y, Matsumoto N, Kondo S, Kitayama H, Noda M
Neuroreport. 2003
PubMed ID: 12824760
H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity.
Thornton C, Yaka R, Dinh S, Ron D
J Biol Chem. 2003
PubMed ID: 12695509
Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis.
Larcher F, Franco M, Bolontrade M, Rodriguez-Puebla M, Casanova L, Navarro M, Yancopoulos G, Jorcano JL, Conti CJ
Mol Carcinog. 2003
PubMed ID: 12766907
Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras.
Marty C, Browning DD, Ye RD
Mol Cell Biol. 2003
PubMed ID: 12748287
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12750467
Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.
Williams JG, Pappu K, Campbell SL
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12740440
[Development of chronic obstructive pulmonary disease correlates with mini- and microsatellite locus instability]
Chizhikov VV, Chikina SIu, Tatosian AG, Chuchalin AG, Zborovskaia IB
Genetika. 2003
PubMed ID: 12838617
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
Nikiforova MN, Lynch RA, Biddinger PW, Alexander EK, Dorn GW, Tallini G, Kroll TG, Nikiforov YE
J Clin Endocrinol Metab. 2003
PubMed ID: 12727991
Conformational states of the switch I region of Ha-ras-p21 in hinge residue mutants studied by fluorescence lifetime and fluorescence anisotropy measurements.
Kuppens S, Hellings M, Jordens J, Verheyden S, Engelborghs Y
Protein Sci. 2003
PubMed ID: 12717016
Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.
Bakovic M, Waite K, Vance DE
J Biol Chem. 2003
PubMed ID: 12584202
The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.
Oliva JL, Pérez-Sala D, Castrillo A, Martínez N, Cañada FJ, Boscá L, Rojas JM
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12684535
Biallelic expression of HRAS and MUCDHL in human and mouse.
Goldberg M, Wei M, Yuan L, Murty VV, Tycko B
Hum Genet. 2003
PubMed ID: 12589428
Overexpression of the peroxisome proliferator activated receptor alpha or the human c-Ha-ras transgene is not involved in tumorigenesis induced by di(2-ethylhexyl)phthalate in rasH2 mice.
Toyosawa K, Okugawa K, Teranishi Y, Tanaka K, Matsuoka N
Cancer Lett. 2003
PubMed ID: 12668284
Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.
Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J
Cell. 2003
PubMed ID: 12628188
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ
Biochim Biophys Acta. 2003
PubMed ID: 12581858
Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation.
Sun P, Yamamoto H, Suetsugu S, Miki H, Takenawa T, Endo T
J Biol Chem. 2003
PubMed ID: 12446704
An unusual H-Ras mutant isolated from a human multiple myeloma line leads to transformation and factor-independent cell growth.
Crowder C, Kopantzev E, Williams K, Lengel C, Miki T, Rudikoff S
Oncogene. 2003
PubMed ID: 12569357
Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.
Yuryev A, Wennogle LP
Genomics. 2003
PubMed ID: 12620389
Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy.
Wheeler MD, Smutney OM, Check JF, Rusyn I, Schulte-Hermann R, Thurman RG
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12388208
Erbin suppresses the MAP kinase pathway.
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L
J Biol Chem. 2003
PubMed ID: 12379659
A single nucleotide polymorphism in the human H-ras proto-oncogene determines the risk of urinary bladder cancer.
Johne A, Roots I, Brockmöller J
Cancer Epidemiol Biomarkers Prev. 2003
PubMed ID: 12540507
Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6.
Xu L, Frankel P, Jackson D, Rotunda T, Boshans RL, D'Souza-Schorey C, Foster DA
Mol Cell Biol. 2003
PubMed ID: 12509462
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
Yu M, Snyderwine EG
Carcinogenesis. 2002
PubMed ID: 12507937
SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor.
Komiyama NH, Watabe AM, Carlisle HJ, Porter K, Charlesworth P, Monti J, Strathdee DJ, O'Carroll CM, Martin SJ, Morris RG, O'Dell TJ, Grant SG
J Neurosci. 2002
PubMed ID: 12427827
The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.
Jimenez C, Hernandez C, Pimentel B, Carrera AC
J Biol Chem. 2002
PubMed ID: 12196526
Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis.
Leder A, Lebel M, Zhou F, Fontaine K, Bishop A, Leder P
Oncogene. 2002
PubMed ID: 12242664
The structural basis for the transition from Ras-GTP to Ras-GDP.
Hall BE, Bar-Sagi D, Nassar N
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12213964
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia.
Reuther GW, Lambert QT, Rebhun JF, Caligiuri MA, Quilliam LA, Der CJ
J Biol Chem. 2002
PubMed ID: 11880369
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
Lambert JM, Lambert QT, Reuther GW, Malliri A, Siderovski DP, Sondek J, Collard JG, Der CJ
Nat Cell Biol. 2002
PubMed ID: 12134164
HRAS1 variable number of tandem repeats polymorphism and risk of bladder cancer.
van Gils CH, Conway K, Li Y, Taylor JA
Int J Cancer. 2002
PubMed ID: 12115522
Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Chockalingam PS, Cholera R, Oak SA, Zheng Y, Jarrett HW, Thomason DB
Am J Physiol Cell Physiol. 2002
PubMed ID: 12107060
ADP-ribosylation and functional effects of Pseudomonas exoenzyme S on cellular RalA.
Fraylick JE, Riese MJ, Vincent TS, Barbieri JT, Olson JC
Biochemistry. 2002
PubMed ID: 12135390
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Oft M, Akhurst RJ, Balmain A
Nat Cell Biol. 2002
PubMed ID: 12105419
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis.
Roy S, Wyse B, Hancock JF
Mol Cell Biol. 2002
PubMed ID: 12077341
A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis.
Casanova ML, Larcher F, Casanova B, Murillas R, Fernández-Aceñero MJ, Villanueva C, Martínez-Palacio J, Ullrich A, Conti CJ, Jorcano JL
Cancer Res. 2002
PubMed ID: 12067982
H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts.
Tanaka Y, Nakayamada S, Fujimoto H, Okada Y, Umehara H, Kataoka T, Minami Y
J Biol Chem. 2002
PubMed ID: 11934900
Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
Parsons BL, Culp SJ, Manjanatha MG, Heflich RH
Carcinogenesis. 2002
PubMed ID: 12082015
Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species.
Cho HJ, Jeong HG, Lee JS, Woo ER, Hyun JW, Chung MH, You HJ
J Biol Chem. 2002
PubMed ID: 11884408
Detection of rare K-ras codon 12 mutations using allele-specific competitive blocker PCR.
McKinzie PB, Parsons BL
Mutat Res. 2002
PubMed ID: 12034322
Transgene stability and features of rasH2 mice as an animal model for short-term carcinogenicity testing.
Suemizu H, Muguruma K, Maruyama C, Tomisawa M, Kimura M, Hioki K, Shimozawa N, Ohnishi Y, Tamaoki N, Nomura T
Mol Carcinog. 2002
PubMed ID: 12112317
Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice.
Okoji RS, Yu RC, Maronpot RR, Froines JR
Carcinogenesis. 2002
PubMed ID: 12016150
The complex of Arl2-GTP and PDE delta: from structure to function.
Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC
EMBO J. 2002
PubMed ID: 11980706
Refinement and delineation of the breakpoint regions of a chromosome 1;22 translocation in a patient with Costello syndrome.
Maróti Z, Kutsche K, Sutajova M, Gal A, Nothwang HG, Czeizel AE, Tímár L, Sólyom E
Am J Med Genet. 2002
PubMed ID: 11977185
Ferritin expression modulates cell cycle dynamics and cell responsiveness to H-ras-induced growth via expansion of the labile iron pool.
Kakhlon O, Gruenbaum Y, Cabantchik ZI
Biochem J. 2002
PubMed ID: 11964143
The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases.
Nancy V, Callebaut I, El Marjou A, de Gunzburg J
J Biol Chem. 2002
PubMed ID: 11786539
Extracellular Nef protein activates signal transduction pathway from Ras to mitogen-activated protein kinase cascades that leads to activation of human immunodeficiency virus from latency.
Tobiume M, Fujinaga K, Suzuki S, Komoto S, Mukai T, Ikuta K
AIDS Res Hum Retroviruses. 2002
PubMed ID: 11958689
SmgGDS displays differential binding and exchange activity towards different Ras isoforms.
Vikis HG, Stewart S, Guan KL
Oncogene. 2002
PubMed ID: 11948427
Mechanical force generation by G proteins.
Kosztin I, Bruinsma R, O'Lague P, Schulten K
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904419
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1.
McDermott EP, O'Neill LA
J Biol Chem. 2002
PubMed ID: 11744690
Ecdysone-inducible expression of oncogenic Ha-Ras in NIH 3T3 cells leads to transient nuclear localization of activated extracellular signal-regulated kinase regulated by mitogen-activated protein kinase phosphatase-1.
Plows D, Briassouli P, Owen C, Zoumpourlis V, Garrett MD, Pintzas A
Biochem J. 2002
PubMed ID: 11853538
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J
Oncogene. 2002
PubMed ID: 11857081
Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.
Schondorf T, Rutzel S, Andrack A, Becker M, Hoopmann M, Breidenbach M, Gohring UJ
Int J Oncol. 2002
PubMed ID: 11788888
Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K.
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC
Oncogene. 2002
PubMed ID: 11840339
Gene expression in the developing mouse retina by EST sequencing and microarray analysis.
Mu X, Zhao S, Pershad R, Hsieh TF, Scarpa A, Wang SW, White RA, Beremand PD, Thomas TL, Gan L, Klein WH
Nucleic Acids Res. 2001
PubMed ID: 11812828
Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody.
Miura K, Lavens-Phillips S, MacGlashan DW
J Immunol. 2001
PubMed ID: 11739523
Basis for signaling specificity difference between Sos and Ras-GRF guanine nucleotide exchange factors.
Tian X, Feig LA
J Biol Chem. 2001
PubMed ID: 11560935
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Gen H, Yamamoto S, Morimura K, Min W, Mitsuhashi M, Murai T, Mori S, Hosono M, Oohara T, Makino S, Wanibuchi H, Fukushima S
Jpn J Cancer Res. 2001
PubMed ID: 11749692
Patterning the optic neuroepithelium by FGF signaling and Ras activation.
Zhao S, Hung FC, Colvin JS, White A, Dai W, Lovicu FJ, Ornitz DM, Overbeek PA
Development. 2001
PubMed ID: 11748141
Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation.
Paz A, Haklai R, Elad-Sfadia G, Ballan E, Kloog Y
Oncogene. 2001
PubMed ID: 11709720
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Scheffzek K, Grünewald P, Wohlgemuth S, Kabsch W, Tu H, Wigler M, Wittinghofer A, Herrmann C
Structure. 2001
PubMed ID: 11709168
Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.
Elowe S, Holland SJ, Kulkarni S, Pawson T
Mol Cell Biol. 2001
PubMed ID: 11585923
Differences in patterns of activation of MAP kinases induced by oncogenic ras-p21 and insulin in oocytes.
Ranginwale M, Smith S, Flom J, Chie L, Kanovsky M, Chung D, Friedman FK, Robinson RC, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR
Exp Cell Res. 2001
PubMed ID: 11525649
Dermal carcinogenicity in transgenic mice: effect of vehicle on responsiveness of hemizygous Tg.AC mice to phorbol 12-myristate 13-acetate (TPA).
Stoll RE, Furst SM, Stoltz JH, Lilly PD, Mennear JH
Toxicol Pathol. 2001
PubMed ID: 11695570
Polymorphisms and colorectal tumor risk.
Houlston RS, Tomlinson IP
Gastroenterology. 2001
PubMed ID: 11487538
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases.
Figueroa C, Taylor J, Vojtek AB
J Biol Chem. 2001
PubMed ID: 11335720
Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.
Giglione C, Gonfloni S, Parmeggiani A
Eur J Biochem. 2001
PubMed ID: 11389730
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas.
Ding H, Roncari L, Shannon P, Wu X, Lau N, Karaskova J, Gutmann DH, Squire JA, Nagy A, Guha A
Cancer Res. 2001
PubMed ID: 11325859
Electroconvulsive shock increases the phosphorylation of Pyk2 in the rat hippocampus.
Jeon SH, Oh SW, Kang UG, Ahn YM, Bae CD, Park JB, Kim YS
Biochem Biophys Res Commun. 2001
PubMed ID: 11352655
Age-dependent skin tumorigenesis and transgene expression in the Tg.AC (v-Ha-ras) transgenic mouse.
Battalora MS, Spalding JW, Szczesniak CJ, Cape JE, Morris RJ, Trempus CS, Bortner CD, Lee BM, Tennant RW
Carcinogenesis. 2001
PubMed ID: 11285202
Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.
Topham MK, Prescott SM
J Cell Biol. 2001
PubMed ID: 11257115
Effect of bacterial metabolism in the intestine on colorectal tumors induced by 1,2-dimethylhydrazine in transgenic mice harboring human prototype c-Ha-ras genes.
Ohno K, Narushima S, Takeuchi S, Itoh K, Itoh T, Hioki K, Nomura T
J Exp Clin Cancer Res. 2001
PubMed ID: 11370830
Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development.
Esteban LM, Vicario-Abejón C, Fernández-Salguero P, Fernández-Medarde A, Swaminathan N, Yienger K, Lopez E, Malumbres M, McKay R, Ward JM, Pellicer A, Santos E
Mol Cell Biol. 2001
PubMed ID: 11238881
Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.
Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T
J Biol Chem. 2001
PubMed ID: 11022048
The rasH2 transgenic mouse: nature of the model and mechanistic studies on tumorigenesis.
Tamaoki N
Toxicol Pathol. 2001
PubMed ID: 11695564
Tg.AC genetically altered mouse: assay working group overview of available data.
Eastin WC, Mennear JH, Tennant RW, Stoll RE, Branstetter DG, Bucher JR, McCullough B, Binder RL, Spalding JW, Mahler JF
Toxicol Pathol. 2001
PubMed ID: 11695563
The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model.
Tennant RW, Stasiewicz S, Eastin WC, Mennear JH, Spalding JW
Toxicol Pathol. 2001
PubMed ID: 11695562
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
Induction of drug metabolism-related enzymes by methylcholanthrene and phenobarbital in transgenic mice carrying human prototype c-Ha-ras gene and their wild type littermates.
Ohnishi Y, Arai T, Koshirakawa M, Horii N, Nakajo S, Urano K, Usui T, Tamaoki N, Ueyama Y
Exp Anim. 2001
PubMed ID: 11326421
Differences in early and late responses between neurotrophin-stimulated trkA- and trkC-transfected SH-SY5Y neuroblastoma cells.
Edsjö A, Hallberg B, Fagerström S, Larsson C, Axelson H, Påhlman S
Cell Growth Differ. 2001
PubMed ID: 11205744
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
Elenbaas B, Spirio L, Koerner F, Fleming MD, Zimonjic DB, Donaher JL, Popescu NC, Hahn WC, Weinberg RA
Genes Dev. 2001
PubMed ID: 11156605
Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration.
Heumann R, Goemans C, Bartsch D, Lingenhöhl K, Waldmeier PC, Hengerer B, Allegrini PR, Schellander K, Wagner EF, Arendt T, Kamdem RH, Obst-Pernberg K, Narz F, Wahle P, Berns H
J Cell Biol. 2000
PubMed ID: 11134081
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma.
Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF, Williams RL
Cell. 2000
PubMed ID: 11136978
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis.
Vos MD, Ellis CA, Bell A, Birrer MJ, Clark GJ
J Biol Chem. 2000
PubMed ID: 10998413
Relationships of TP53 codon 72 and HRAS1 polymorphisms with lung cancer risk in an ethnically diverse population.
Pierce LM, Sivaraman L, Chang W, Lum A, Donlon T, Seifried A, Wilkens LR, Lau AF, Le Marchand L
Cancer Epidemiol Biomarkers Prev. 2000
PubMed ID: 11097227
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Tang MS, Vulimiri SV, Viaje A, Chen JX, Bilolikar DS, Morris RJ, Harvey RG, Slaga TJ, DiGiovanni J
Cancer Res. 2000
PubMed ID: 11059761
Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1.
Kiyono M, Kato J, Kataoka T, Kaziro Y, Satoh T
J Biol Chem. 2000
PubMed ID: 10882715
Mammary tumor development in MMTV-c-myc/MMTV-v-Ha-ras transgenic mice is unaffected by osteopontin deficiency.
Feng F, Rittling SR
Breast Cancer Res Treat. 2000
PubMed ID: 11079161
A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras.
Shao H, Andres DA
J Biol Chem. 2000
PubMed ID: 10869344
RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD
Biochem J. 2000
PubMed ID: 10926822
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.
Boettner B, Govek EE, Cross J, Van Aelst L
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922060
Evidence for a telomere-independent "clock" limiting RAS oncogene-driven proliferation of human thyroid epithelial cells.
Jones CJ, Kipling D, Morris M, Hepburn P, Skinner J, Bounacer A, Wyllie FS, Ivan M, Bartek J, Wynford-Thomas D, Bond JA
Mol Cell Biol. 2000
PubMed ID: 10891505
Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.
Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG
Nat Neurosci. 2000
PubMed ID: 10862698
Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts.
Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L
Mol Cell Biol. 2000
PubMed ID: 10848592
Mapping of atypical protein kinase C within the nerve growth factor signaling cascade: relationship to differentiation and survival of PC12 cells.
Wooten MW, Seibenhener ML, Neidigh KB, Vandenplas ML
Mol Cell Biol. 2000
PubMed ID: 10848576
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Ise K, Nakamura K, Nakao K, Shimizu S, Harada H, Ichise T, Miyoshi J, Gondo Y, Ishikawa T, Aiba A, Katsuki M
Oncogene. 2000
PubMed ID: 10871846
Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident.
Romanenko A, Morimura K, Wanibuchi H, Salim EI, Kinoshita A, Kaneko M, Vozianov A, Fukushima S
Int J Cancer. 2000
PubMed ID: 10842192
Hepatic drug metabolizing enzymes induced by clofibrate in rasH2 mice.
Katsutani N, Sekido T, Aoki T, Sagami F
Toxicol Lett. 2000
PubMed ID: 10814892
Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway.
Manninen A, Renkema GH, Saksela K
J Biol Chem. 2000
PubMed ID: 10748182
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.
Li W, Han M, Guan KL
Genes Dev. 2000
PubMed ID: 10783161
Lack of association of rare alleles in the HRAS variable number of tandem repeats (VNTR) region with adult glioma.
Chen P, Wiencke JK, Conway K, Edmiston SN, Miike R, Wrensch M
Neuro Oncol. 2000
PubMed ID: 11303621
Ras-induced cellular events (review).
Ayllón V, Rebollo A
Mol Membr Biol. 2000
PubMed ID: 10989457
Neurofibromin negatively regulates neurotrophin signaling through p21ras in embryonic sensory neurons.
Vogel KS, El-Afandi M, Parada LF
Mol Cell Neurosci. 2000
PubMed ID: 10845775
Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation.
Manabe T, Aiba A, Yamada A, Ichise T, Sakagami H, Kondo H, Katsuki M
J Neurosci. 2000
PubMed ID: 10729330
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
Reuther GW, Der CJ
Curr Opin Cell Biol. 2000
PubMed ID: 10712923
Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases.
Deng X, Ruvolo P, Carr B, May WS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10677502
H RAS mutations in haematologically normal individuals.
Taylor C, Larghero J, Thomas C, Warren N, Carter G, Hughes D, Culligan D, Al-Sabah A, Whittaker JA, Chomienne C, Padua RA
Hematol J. 2000
PubMed ID: 11920220
The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.
Scheidig AJ, Burmester C, Goody RS
Structure. 1999
PubMed ID: 10574788
Biochemical characterization of the Ras-related GTPases Rit and Rin.
Shao H, Kadono-Okuda K, Finlin BS, Andres DA
Arch Biochem Biophys. 1999
PubMed ID: 10545207
CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.
Nosaka Y, Arai A, Miyasaka N, Miura O
J Biol Chem. 1999
PubMed ID: 10514505
Transient palmitoylation supports H-Ras membrane binding but only partial biological activity.
Coats SG, Booden MA, Buss JE
Biochemistry. 1999
PubMed ID: 10504264
Bcl-2 differentially targets K-, N-, and H-Ras to mitochondria in IL-2 supplemented or deprived cells: implications in prevention of apoptosis.
Rebollo A, Pérez-Sala D, Martínez-A C
Oncogene. 1999
PubMed ID: 10490827
NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling.
Romashkova JA, Makarov SS
Nature. 1999
PubMed ID: 10485711
Small GTPases and cell cycle regulation.
Marshall CJ
Biochem Soc Trans. 1999
PubMed ID: 10917603
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.
Nguyen DH, Catling AD, Webb DJ, Sankovic M, Walker LA, Somlyo AV, Weber MJ, Gonias SL
J Cell Biol. 1999
PubMed ID: 10402467
Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.
Romero F, Martínez-A C, Camonis J, Rebollo A
EMBO J. 1999
PubMed ID: 10369681
In vivo interaction of AF-6 with activated Ras and ZO-1.
Yamamoto T, Harada N, Kawano Y, Taya S, Kaibuchi K
Biochem Biophys Res Commun. 1999
PubMed ID: 10334923
A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase.
Hanna AN, Chan EY, Xu J, Stone JC, Brindley DN
J Biol Chem. 1999
PubMed ID: 10212255
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ, Young SG
J Biol Chem. 1999
PubMed ID: 10085069
A non-farnesylated Ha-Ras protein can be palmitoylated and trigger potent differentiation and transformation.
Booden MA, Baker TL, Solski PA, Der CJ, Punke SG, Buss JE
J Biol Chem. 1999
PubMed ID: 9880516
Genetic events and the role of TGF beta in epithelial tumour progression.
Akhurst RJ, Balmain A
J Pathol. 1999
PubMed ID: 10341708
Insights into cancer from transgenic mouse models.
Macleod KF, Jacks T
J Pathol. 1999
PubMed ID: 10341706
p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.
Klesse LJ, Parada LF
J Neurosci. 1998
PubMed ID: 9852579
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling.
Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW
Genes Dev. 1998
PubMed ID: 9765203
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Kim K, Cai J, Shuja S, Kuo T, Murnane MJ
Int J Cancer. 1998
PubMed ID: 9699522
The structural basis of the activation of Ras by Sos.
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J
Nature. 1998
PubMed ID: 9690470
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
Sieburth DS, Sun Q, Han M
Cell. 1998
PubMed ID: 9674433
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.
Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC
Science. 1998
PubMed ID: 9582122
Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness.
Tang Z, Qin L, Wang X, Zhou G, Liao Y, Weng Y, Jiang X, Lin Z, Liu K, Ye S
Chin Med J (Engl). 1998
PubMed ID: 10374394
Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS.
Shirouzu M, Morinaka K, Koyama S, Hu CD, Hori-Tamura N, Okada T, Kariya K, Kataoka T, Kikuchi A, Yokoyama S
J Biol Chem. 1998
PubMed ID: 9516482
Identification of Nore1 as a potential Ras effector.
Vavvas D, Li X, Avruch J, Zhang XF
J Biol Chem. 1998
PubMed ID: 9488663
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
Sun J, Qian Y, Hamilton AD, Sebti SM
Oncogene. 1998
PubMed ID: 9525745
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Auer KL, Contessa J, Brenz-Verca S, Pirola L, Rusconi S, Cooper G, Abo A, Wymann MP, Davis RJ, Birrer M, Dent P
Mol Biol Cell. 1998
PubMed ID: 9487126
Signals transduced through the CD4 molecule interfere with TCR/CD3-mediated ras activation leading to T cell anergy/apoptosis.
Tamma SM, Chirmule N, McCloskey TW, Oyaizu N, Kalyanaraman VS, Pahwa S
Clin Immunol Immunopathol. 1997
PubMed ID: 9344703
K-ras is an essential gene in the mouse with partial functional overlap with N-ras.
Johnson L, Greenbaum D, Cichowski K, Mercer K, Murphy E, Schmitt E, Bronson RT, Umanoff H, Edelmann W, Kucherlapati R, Jacks T
Genes Dev. 1997
PubMed ID: 9334313
14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain.
Clark GJ, Drugan JK, Rossman KL, Carpenter JW, Rogers-Graham K, Fu H, Der CJ, Campbell SL
J Biol Chem. 1997
PubMed ID: 9261098
CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.
Tamma SM, Chirmule N, Yagura H, Oyaizu N, Kalyanaraman V, Pahwa S
Blood. 1997
PubMed ID: 9269777
Ras effectors and their role in mitogenesis and oncogenesis.
Joneson T, Bar-Sagi D
J Mol Med. 1997
PubMed ID: 9297626
p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
Chantry D, Vojtek A, Kashishian A, Holtzman DA, Wood C, Gray PW, Cooper JA, Hoekstra MF
J Biol Chem. 1997
PubMed ID: 9235916
The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Scheffzek K, Ahmadian MR, Kabsch W, Wiesmüller L, Lautwein A, Schmitz F, Wittinghofer A
Science. 1997
PubMed ID: 9219684
Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells.
Stang S, Bottorff D, Stone JC
Mol Cell Biol. 1997
PubMed ID: 9154803
Protein binding and signaling properties of RIN1 suggest a unique effector function.
Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9144171
Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras.
Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J
Cell. 1997
PubMed ID: 9150145
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9113989
Physical association with ras enhances activation of membrane-bound raf (RafCAAX).
Mineo C, Anderson RG, White MA
J Biol Chem. 1997
PubMed ID: 9099670
Signal transduction by the neurotrophin receptors.
Kaplan DR, Miller FD
Curr Opin Cell Biol. 1997
PubMed ID: 9069267
The complexity of Raf-1 regulation.
Morrison DK, Cutler RE
Curr Opin Cell Biol. 1997
PubMed ID: 9069260
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW
Cell. 1997
PubMed ID: 9054499
RalGDS functions in Ras- and cAMP-mediated growth stimulation.
Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL
J Biol Chem. 1997
PubMed ID: 9038168
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction.
Lander HM, Hajjar DP, Hempstead BL, Mirza UA, Chait BT, Campbell S, Quilliam LA
J Biol Chem. 1997
PubMed ID: 9020151
Ras activation in platelets after stimulation of the thrombin receptor, thromboxane A2 receptor or protein kinase C.
Shock DD, He K, Wencel-Drake JD, Parise LV
Biochem J. 1997
PubMed ID: 9020890
Targeted oncogenesis in the thyroid of transgenic mice.
Feunteun J, Michiels F, Rochefort P, Caillou B, Talbot M, Fournes B, Mercken L, Schlumberger M, Monier R
Horm Res. 1997
PubMed ID: 9167944
Induction of murine CD5 expression by v-H-ras.
Weichert TR, Schwartz RC
Immunology. 1997
PubMed ID: 9038709
RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG.
Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B
J Biol Chem. 1996
PubMed ID: 8939998
Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.
Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC
J Biol Chem. 1996
PubMed ID: 8939933
MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation.
Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin MF, Taketo MM
Development. 1996
PubMed ID: 8787751
Loss of Raf-1-binding activity of v-Ha-Ras by the deletion of amino acid residues 64-72 and 143-151.
Hiwasa T, Kasama M, Nakadai T, Sawada T, Sakiyama S
Cell Signal. 1996
PubMed ID: 8911690
Regulation of neuromodulatory actions of angiotensin II in the brain neurons by the Ras-dependent mitogen-activated protein kinase pathway.
Yang H, Lu D, Yu K, Raizada MK
J Neurosci. 1996
PubMed ID: 8753867
p120 Ras GTPase-activating protein interacts with Ras-GTP through specific conserved residues.
Miao W, Eichelberger L, Baker L, Marshall MS
J Biol Chem. 1996
PubMed ID: 8663024
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.
Rodriguez-Viciana P, Warne PH, Vanhaesebroeck B, Waterfield MD, Downward J
EMBO J. 1996
PubMed ID: 8665852
Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes.
Dudler T, Gelb MH
J Biol Chem. 1996
PubMed ID: 8626715
Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles.
Morcos P, Thapar N, Tusneem N, Stacey D, Tamanoi F
Mol Cell Biol. 1996
PubMed ID: 8628317
Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains.
Song KS, Li Shengwen, Okamoto T, Quilliam LA, Sargiacomo M, Lisanti MP
J Biol Chem. 1996
PubMed ID: 8621645
The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26.
Elson A, Kozak CA, Morton CC, Weremowicz S, Leder P
Genomics. 1996
PubMed ID: 8838320
Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.
Guha A, Lau N, Huvar I, Gutmann D, Provias J, Pawson T, Boss G
Oncogene. 1996
PubMed ID: 8637706
Nucleotide sequence of c-H-ras-1 gene from B6C3F1 mice.
Przybojewska B, Płucienniczak G
Acta Biochim Pol. 1996
PubMed ID: 8922043
Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse chromosomes 1 and 7.
Guenet JL, Simon-Chazottes D, Gravel M, Hastings KE, Schiaffino S
Mamm Genome. 1996
PubMed ID: 8903721
Molecular analysis of Ras activation by tyrosine phosphorylated Vav.
Gulbins E, Schlottmann K, Brenner B, Lang F, Coggeshall KM
Biochem Biophys Res Commun. 1995
PubMed ID: 8554611
Cysteine-rich region of Raf-1 interacts with activator domain of post-translationally modified Ha-Ras.
Hu CD, Kariya K, Tamada M, Akasaka K, Shirouzu M, Yokoyama S, Kataoka T
J Biol Chem. 1995
PubMed ID: 8530446
Ras-related proteins in signal transduction and growth control.
McCormick F
Mol Reprod Dev. 1995
PubMed ID: 8607982
Hepatocarcinogenesis in BXH recombinant inbred strains of mice: analysis of diverse phenotypic effects of the hepatocarcinogen sensitivity loci.
Lee GH, Drinkwater NR
Mol Carcinog. 1995
PubMed ID: 7576111
Mouse gastric mucin: cloning and chromosomal localization.
Shekels LL, Lyftogt C, Kieliszewski M, Filie JD, Kozak CA, Ho SB
Biochem J. 1995
PubMed ID: 7487932
Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors.
Maronpot RR, Fox T, Malarkey DE, Goldsworthy TL
Toxicology. 1995
PubMed ID: 7676462
Distinct genetic loci control development of benign and malignant skin tumours in mice.
Nagase H, Bryson S, Cordell H, Kemp CJ, Fee F, Balmain A
Nat Genet. 1995
PubMed ID: 7670492
Ras binding to a C-terminal region of GAP.
Molloy DP, Owen D, Grand RJ
FEBS Lett. 1995
PubMed ID: 7628625
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.
Galaktionov K, Jessus C, Beach D
Genes Dev. 1995
PubMed ID: 7744247
Two distinct Raf domains mediate interaction with Ras.
Brtva TR, Drugan JK, Ghosh S, Terrell RS, Campbell-Burk S, Bell RM, Der CJ
J Biol Chem. 1995
PubMed ID: 7730360
Uroporphyrinogen-III synthase: molecular cloning, nucleotide sequence, expression of a mouse full-length cDNA, and its localization on mouse chromosome 7.
Xu W, Kozak CA, Desnick RJ
Genomics. 1995
PubMed ID: 7607680
Biochemical analysis of MEK activation in NIH3T3 fibroblasts. Identification of B-Raf and other activators.
Reuter CW, Catling AD, Jelinek T, Weber MJ
J Biol Chem. 1995
PubMed ID: 7706312
A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1.
Han L, Colicelli J
Mol Cell Biol. 1995
PubMed ID: 7862125
Distribution of p21ras during primary palate formation of non-cleft and cleft strains of mice.
Wang KY, Chen KC, Chiang CP, Kuo MY
J Oral Pathol Med. 1995
PubMed ID: 7776260
Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).
Kozak CA, Gatignol A, Graham K, Jeang KT, McBride OW
Genomics. 1995
PubMed ID: 7774957
Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap.
Spaargaren M, Bischoff JR
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7809086
RAS and RAF-1 form a signalling complex with MEK-1 but not MEK-2.
Jelinek T, Catling AD, Reuter CW, Moodie SA, Wolfman A, Weber MJ
Mol Cell Biol. 1994
PubMed ID: 7969158
Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.
Hofer F, Fields S, Schneider C, Martin GS
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7972015
Spontaneous mutation at codon 61 of the Ha-ras gene in the nascent liver of B6C3F1, C3H/He and C57BL/6 mice.
Moulds BA, Goodman JI
Mutat Res. 1994
PubMed ID: 7526162
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE
J Biol Chem. 1994
PubMed ID: 7523381
SENCAR mouse skin tumors produced by promotion alone have A to G mutations in codon 61 of the c-rasHa gene.
Sutter C, Greenhalgh DA, Ueda M, Abhyankar S, Ngai P, Hennings H, Schweizer J, Yuspa SH, Strickland JE
Carcinogenesis. 1994
PubMed ID: 7522983
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
Chuang E, Barnard D, Hettich L, Zhang XF, Avruch J, Marshall MS
Mol Cell Biol. 1994
PubMed ID: 8035810
Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.
Kraulis PJ, Domaille PJ, Campbell-Burk SL, Van Aken T, Laue ED
Biochemistry. 1994
PubMed ID: 8142349
JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ
Cell. 1994
PubMed ID: 8137421
Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation.
Hallberg B, Rayter SI, Downward J
J Biol Chem. 1994
PubMed ID: 8307946
Presence and possible role of c-ras and nuclear (c-fos and c-jun) proto-oncogene products in preimplantation embryonic development in mice.
Ahmad K, Naz RK
Mol Reprod Dev. 1993
PubMed ID: 8286110
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Suen KL, Bustelo XR, Pawson T, Barbacid M
Mol Cell Biol. 1993
PubMed ID: 7689150
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro.
Warne PH, Viciana PR, Downward J
Nature. 1993
PubMed ID: 8332195
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.
Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J
Nature. 1993
PubMed ID: 8332187
Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP.
Löw A, Sprinzl M, Faulhammer HG
Eur J Biochem. 1993
PubMed ID: 8393791
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J
Science. 1993
PubMed ID: 8316835
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Imamura N, Kuramoto A, Ishihara H, Shimizu S
Am J Hematol. 1993
PubMed ID: 7916576
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
Genetic mapping of three GABAA receptor-subunit genes in the mouse.
Danciger M, Farber DB, Kozak CA
Genomics. 1993
PubMed ID: 8390964
Multiple tumor types appear in a transgenic mouse with the ras oncogene.
Cardiff RD, Leder A, Kuo A, Pattengale PK, Leder P
Am J Pathol. 1993
PubMed ID: 8475993
Possible association of c-Harvey-Ras-1 (HRAS-1) marker with autism.
Hérault J, Perrot A, Barthélémy C, Büchler M, Cherpi C, Leboyer M, Sauvage D, Lelord G, Mallet J, Müh JP
Psychiatry Res. 1993
PubMed ID: 8098541
Chromosome mapping of murine susceptibility loci to liver carcinogenesis.
Gariboldi M, Manenti G, Canzian F, Falvella FS, Pierotti MA, Della Porta G, Binelli G, Dragani TA
Cancer Res. 1993
PubMed ID: 8417808
Reassignment of the H-ras-1 gene to the Hbb-terminus region of mouse chromosome 7.
Bianchi AB, Rinchik EM, Conti CJ
Mamm Genome. 1993
PubMed ID: 8499656
Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand.
Kiba T, Tsuda H, Pairojkul C, Inoue S, Sugimura T, Hirohashi S
Mol Carcinog. 1993
PubMed ID: 8280380
Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice.
DiGiovanni J, Beltrán L, Rupp A, Harvey RG, Gill RD
Mol Carcinog. 1993
PubMed ID: 8280375
A revised map position for the Ha-ras gene on mouse chromosome 7: implications for analysis of genetic alterations in rodent tumors.
Kemp CJ, Bremner R, Balmain A
Mol Carcinog. 1993
PubMed ID: 8098216
Novel RFLPs at protooncogene and cancer-related gene loci on mouse chromosomes.
Santos J, Pellicer A
Cytogenet Cell Genet. 1993
PubMed ID: 8095010
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.
Sakai E, Rikimaru K, Ueda M, Matsumoto Y, Ishii N, Enomoto S, Yamamoto H, Tsuchida N
Int J Cancer. 1992
PubMed ID: 1459726
The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development.
Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB, Brannan CI, Jenkins NA, Copeland NG, Rabbitts TH
J Mol Biol. 1992
PubMed ID: 1507224
Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
Copeland NG, Gilbert DJ, Chrétien M, Seidah NG, Jenkins NA
Genomics. 1992
PubMed ID: 1354647
Cellular proto-oncogene expression following exposure of mice to gamma rays.
Anderson A, Woloschak GE
Radiat Res. 1992
PubMed ID: 1594760
An interaction between p21ras and heat shock protein hsp60, a chaperonin.
Ikawa S, Weinberg RA
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1347942
PCR detection of an insertion/deletion polymorphism in intron 1 of the HRAS1 locus.
Tanci P, Genuardi M, Santini SA, Neri G
Nucleic Acids Res. 1992
PubMed ID: 1549493
Polymorphisms revealed by PCR with single, short-sized, arbitrary primers are reliable markers for mouse and rat gene mapping.
Serikawa T, Montagutelli X, Simon-Chazottes D, Guénet JL
Mamm Genome. 1992
PubMed ID: 1617216
Chromosomal localization of the rat Harvey-ras-1 gene (HRAS) by in situ hybridization.
Gollahon LS, Aldaz CM
Cytogenet Cell Genet. 1992
PubMed ID: 1395719
A set of anonymous DNA clones as markers for mouse gene mapping.
Le Roy H, Simon-Chazottes D, Montagutelli X, Guénet JL
Mamm Genome. 1992
PubMed ID: 1351769
Localization of growth arrest-specific genes on mouse chromosomes 1, 7, 8, 11, 13, and 16.
Colombo MP, Martinotti A, Howard TA, Schneider C, D'Eustachio P, Seldin MF
Mamm Genome. 1992
PubMed ID: 1347472
Analysis of the Ha-ras oncogene in C3H/He mouse liver tumours derived spontaneously or induced with diethylnitrosamine or phenobarbitone.
Rumsby PC, Barrass NC, Phillimore HE, Evans JG
Carcinogenesis. 1991
PubMed ID: 1747936
Posttranslational modification of Ha-ras p21 by farnesyl versus geranylgeranyl isoprenoids is determined by the COOH-terminal amino acid.
Kinsella BT, Erdman RA, Maltese WA
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1924354
Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes.
Bhatia K, Huppi K, McKeithan T, Siwarski D, Mushinski JF, Magrath I
Oncogene. 1991
PubMed ID: 1923524
Transgenic oncogene mice. Tumor phenotype predicts genotype.
Cardiff RD, Sinn E, Muller W, Leder P
Am J Pathol. 1991
PubMed ID: 1887859
The gene map of the Norway rat (Rattus norvegicus) and comparative mapping with mouse and man.
Levan G, Szpirer J, Szpirer C, Klinga K, Hanson C, Islam MQ
Genomics. 1991
PubMed ID: 1889815
Transforming function of proto-ras genes depends on heterologous promoters and is enhanced by specific point mutations.
Chakraborty AK, Cichutek K, Duesberg PH
Proc Natl Acad Sci U S A. 1991
PubMed ID: 2006160
Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP.
Tong LA, de Vos AM, Milburn MV, Kim SH
J Mol Biol. 1991
PubMed ID: 1899707
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid.
Leder A, Kuo A, Cardiff RD, Sinn E, Leder P
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2251261
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP).
Gibbs JB, Marshall MS, Scolnick EM, Dixon RA, Vogel US
J Biol Chem. 1990
PubMed ID: 2122974
A molecular genetic linkage map of mouse chromosome 7.
Saunders AM, Seldin MF
Genomics. 1990
PubMed ID: 1981054
Identification and preliminary characterization of protein-cysteine farnesyltransferase.
Manne V, Roberts D, Tobin A, O'Rourke E, De Virgilio M, Meyers C, Ahmed N, Kurz B, Resh M, Kung HF
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2217184
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
Pai EF, Krengel U, Petsko GA, Goody RS, Kabsch W, Wittinghofer A
EMBO J. 1990
PubMed ID: 2196171
Unique guanine nucleotide binding properties of the human placental GTP-binding protein Gp.
Tamir A, Fawzi AB, Northup JK
Biochemistry. 1990
PubMed ID: 2121270
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Bremner R, Balmain A
Cell. 1990
PubMed ID: 2185890
Transforming genes from familial adenomatous polyposis patient cells detected by a tumorigenicity assay.
Yuasa Y, Kamiyama T, Kato M, Iwama T, Ikeuchi T, Tonomura A
Oncogene. 1990
PubMed ID: 1970154
The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q.
Saunders AM, Seldin MF
Genomics. 1990
PubMed ID: 2307474
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation.
Pai EF, Kabsch W, Krengel U, Holmes KC, John J, Wittinghofer A
Nature. 1989
PubMed ID: 2476675
All ras proteins are polyisoprenylated but only some are palmitoylated.
Hancock JF, Magee AI, Childs JE, Marshall CJ
Cell. 1989
PubMed ID: 2661017
Oncogene-induced liver neoplasia in transgenic mice.
Sandgren EP, Quaife CJ, Pinkert CA, Palmiter RD, Brinster RL
Oncogene. 1989
PubMed ID: 2543942
Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of c-H-ras-1 and concurrent amplifications of c-erbB-1 and c-myc.
Tadokoro K, Ueda M, Ohshima T, Fujita K, Rikimaru K, Takahashi N, Enomoto S, Tsuchida N
Oncogene. 1989
PubMed ID: 2654810
Ha-ras and c-myc oncogene expression interferes with morphological and functional differentiation of mammary epithelial cells in single and double transgenic mice.
Andres AC, van der Valk MA, Schönenberger CA, Flückiger F, LeMeur M, Gerlinger P, Groner B
Genes Dev. 1988
PubMed ID: 2463212
Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
Barton DE, Kwon BS, Francke U
Genomics. 1988
PubMed ID: 3146546
Characterization of mutagen-activated cellular oncogenes that confer anchorage independence to human fibroblasts and tumorigenicity to NIH 3T3 cells: sequence analysis of an enzymatically amplified mutant HRAS allele.
Stevens CW, Manoharan TH, Fahl WE
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3131765
Guanosine triphosphatase activating protein (GAP) interacts with the p21 ras effector binding domain.
Adari H, Lowy DR, Willumsen BM, Der CJ, McCormick F
Science. 1988
PubMed ID: 2833817
Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.
de Vos AM, Tong L, Milburn MV, Matias PM, Jancarik J, Noguchi S, Nishimura S, Miura K, Ohtsuka E, Kim SH
Science. 1988
PubMed ID: 2448879
Detection of a low frequency of activated ras genes in human melanomas using a tumorigenicity assay.
Raybaud F, Noguchi T, Marics I, Adelaide J, Planche J, Batoz M, Aubert C, de Lapeyriere O, Birnbaum D
Cancer Res. 1988
PubMed ID: 3276402
The rat gene map.
Szpirer C, Szpirer J, Islam MQ, Levan G
Curr Top Microbiol Immunol. 1988
PubMed ID: 3416641
The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse.
Brissenden JE, Caras I, Thelander L, Francke U
Exp Cell Res. 1988
PubMed ID: 3275546
Isolation and characterization of the 5' flanking region of the mouse c-Harvey-ras gene.
Brown K, Bailleul B, Ramsden M, Fee F, Krumlauf R, Balmain A
Mol Carcinog. 1988
PubMed ID: 3074812
Identification of the principal promoter sequence of the c-H-ras transforming oncogene: deletion analysis of the 5'-flanking region by focus formation assay.
Honkawa H, Masahashi W, Hashimoto S, Hashimoto-Gotoh T
Mol Cell Biol. 1987
PubMed ID: 3670300
A c-ras-Ki oncogene is activated, amplified and overexpressed in a human osteosarcoma cell line.
Nardeux PC, Daya-Grosjean L, Landin RM, Andéol Y, Suàrez HG
Biochem Biophys Res Commun. 1987
PubMed ID: 3476115
Interaction of the human insulin receptor with the ras oncogene product p21.
O'Brien RM, Siddle K, Houslay MD, Hall A
FEBS Lett. 1987
PubMed ID: 3109943
Activated c-Ha-ras oncogene with a guanine to thymine transversion at the twelfth codon in a human stomach cancer cell line.
Deng GR, Lu YY, Chen SM, Miao J, Lu GR, Li H, Cai H, Xu XL, E Z, Liu PN
Cancer Res. 1987
PubMed ID: 3034404
A point mutation at codon 13 of the N-ras oncogene in myelodysplastic syndrome.
Hirai H, Kobayashi Y, Mano H, Hagiwara K, Maru Y, Omine M, Mizoguchi H, Nishida J, Takaku F
Nature. 1987
PubMed ID: 3295562
Ha-ras oncogene expression directed by a milk protein gene promoter: tissue specificity, hormonal regulation, and tumor induction in transgenic mice.
Andres AC, Schönenberger CA, Groner B, Hennighausen L, LeMeur M, Gerlinger P
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3469670
Amino-acid substitution at codon 13 of the N-ras oncogene in rectal cancer in a Japanese patient.
Nitta N, Ochiai M, Nagao M, Sugimura T
Jpn J Cancer Res. 1987
PubMed ID: 3102434
Chromosomal mapping of beta-globin and albino loci in the domestic cat. A conserved mammalian chromosome group.
O'Brien SJ, Haskins ME, Winkler CA, Nash WG, Patterson DF
J Hered. 1986
PubMed ID: 3559163
Isolation of ras GTP-binding mutants using an in situ colony-binding assay.
Feig LA, Pan BT, Roberts TM, Cooper GM
Proc Natl Acad Sci U S A. 1986
PubMed ID: 3088563
Nucleotide sequence of the two rat cellular rasH genes.
Ruta M, Wolford R, Dhar R, Defeo-Jones D, Ellis RW, Scolnick EM
Mol Cell Biol. 1986
PubMed ID: 3023901
Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities.
Lacal JC, Anderson PS, Aaronson SA
EMBO J. 1986
PubMed ID: 3011420
Assignment of RAS proto-oncogenes in Chinese hamsters: implications for mammalian gene linkage conservation and neoplasia.
Stallings RL, Crawford BD, Black RJ, Chang EH
Cytogenet Cell Genet. 1986
PubMed ID: 3022995
Transforming genes in human leukemia cells.
Hirai H, Tanaka S, Azuma M, Anraku Y, Kobayashi Y, Fujisawa M, Okabe T, Urabe A, Takaku F
Blood. 1985
PubMed ID: 2998510
Loss of genes on the short arm of chromosome 11 in bladder cancer.
Fearon ER, Feinberg AP, Hamilton SH, Vogelstein B
Nature. 1985
PubMed ID: 2999610
Transforming activity of the c-Ha-ras oncogene having two point mutations in codons 12 and 61.
Sekiya T, Prassolov VS, Fushimi M, Nishimura S
Jpn J Cancer Res. 1985
PubMed ID: 3932284
Essential region for transforming activity of human c-Ha-ras-1.
Sekiya T, Tokunaga A, Fushimi M
Jpn J Cancer Res. 1985
PubMed ID: 3932274
Human N-ras: cDNA cloning and gene structure.
Hall A, Brown R
Nucleic Acids Res. 1985
PubMed ID: 2991860
Activation of an N-ras gene in acute myeloblastic leukemia through somatic mutation in the first exon.
Gambke C, Hall A, Moroni C
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3856237
Assignment of three rat cellular RAS oncogenes to chromosomes 1, 4, and X.
Szpirer J, Defeo-Jones D, Ellis RW, Levan G, Szpirer C
Somat Cell Mol Genet. 1985
PubMed ID: 3856333
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
Taya Y, Hosogai K, Hirohashi S, Shimosato Y, Tsuchiya R, Tsuchida N, Fushimi M, Sekiya T, Nishimura S
EMBO J. 1984
PubMed ID: 6098458
Expression of cellular oncogenes during embryonic and fetal development of the mouse.
Slamon DJ, Cline MJ
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6594688
Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.
Sekiya T, Fushimi M, Hori H, Hirohashi S, Nishimura S, Sugimura T
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6087347
Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells.
Yuasa Y, Gol RA, Chang A, Chiu IM, Reddy EP, Tronick SR, Aaronson SA
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6587382
Mechanism of activation of an N-ras gene in the human fibrosarcoma cell line HT1080.
Brown R, Marshall CJ, Pennie SG, Hall A
EMBO J. 1984
PubMed ID: 6086315
Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983), Seventh International Workshop on Human Gene Mapping.

Cytogenet Cell Genet. 1984
PubMed ID: 6690234
Expression of H-Y antigen by female mice carrying Sxr.
Simpson E, McLaren A, Chandler P, Tomonari K
Transplantation. 1984
PubMed ID: 6364482
Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes.
Sakaguchi AY, Lalley PA, Zabel BU, Ellis RW, Scolnick EM, Naylor SL
Proc Natl Acad Sci U S A. 1984
PubMed ID: 6320193
Assignment of murine cellular Harvey ras gene to chromosome 7.
Pravtcheva DD, Ruddle FH, Ellis RW, Scolnick EM
Somatic Cell Genet. 1983
PubMed ID: 6318374
The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour.
de Martinville B, Francke U
Nature. 1983
PubMed ID: 6312329
Structure and activation of the human N-ras gene.
Taparowsky E, Shimizu K, Goldfarb M, Wigler M
Cell. 1983
PubMed ID: 6616621
Spontaneous activation of a human proto-oncogene.
Santos E, Reddy EP, Pulciani S, Feldmann RJ, Barbacid M
Proc Natl Acad Sci U S A. 1983
PubMed ID: 6308640
Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7.
Kozak CA, Sears JF, Hoggan MD
J Virol. 1983
PubMed ID: 6864883
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
Yuasa Y, Srivastava SK, Dunn CY, Rhim JS, Reddy EP, Aaronson SA
Nature. 1983
PubMed ID: 6866079
Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.
Reddy EP
Science. 1983
PubMed ID: 6844927
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.
Capon DJ, Chen EY, Levinson AD, Seeburg PH, Goeddel DV
Nature. 1983
PubMed ID: 6298635
Expression of c-onc genes: c-fos transcripts accumulate to high levels during development of mouse placenta, yolk sac and amnion.
Müller R, Verma IM, Adamson ED
EMBO J. 1983
PubMed ID: 6641714
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.
Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M
Nature. 1982
PubMed ID: 7177195
Mechanism of activation of a human oncogene.
Tabin CJ, Bradley SM, Bargmann CI, Weinberg RA, Papageorge AG, Scolnick EM, Dhar R, Lowy DR, Chang EH
Nature. 1982
PubMed ID: 6290897
Differential expression of cellular oncogenes during pre- and postnatal development of the mouse.
Müller R, Slamon DJ, Tremblay JM, Cline MJ, Verma IM
Nature. 1982
PubMed ID: 6289129
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes.
Santos E, Tronick SR, Aaronson SA, Pulciani S, Barbacid M
Nature. 1982
PubMed ID: 6283384
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes.
Ellis RW, Defeo D, Shih TY, Gonda MA, Young HA, Tsuchida N, Lowy DR, Scolnick EM
Nature. 1981
PubMed ID: 6265801
Identification of a normal vertebrate cell protein related to the p21 src of Harvey murine sarcoma virus.
Langbeheim H, Shih TY, Scolnick EM
Virology. 1980
PubMed ID: 6254252
Guanine nucleotide-binding and autophosphorylating activities associated with the p21src protein of Harvey murine sarcoma virus.
Shih TY, Papageorge AG, Stokes PE, Weeks MO, Scolnick EM
Nature. 1980
PubMed ID: 6253810
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Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3265	15461	293621
EnsEMBL Gene(s)	ENSG00000174775	ENSMUSG00000025499	ENSRNOG00000016611
Unigene	Hs.37003	Mm.334313	Rn.102180
Homologene	HRAS	Hras1	Hras
OMIM	190020	N/A	N/A
GeneCards	HRAS	N/A	N/A
Beta Cell Genomics	DT.412426 DT.95375678	DT.101380088 DT.101380090 DT.534773 DT.55194301	N/A
Reactome	P01112	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	3265	15461	293621

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
HRAS	RASGRP1	HPRD	empirical	9582122
HRAS	RABAC1	HPRD, IntAct	empirical	11335720
HRAS	RAPGEF4	IntAct	empirical	16316996
HRAS	RASSF1	HPRD, MINT, IntAct, BioGRID	empirical	10998413 18596699 16810318 11857081
HRAS	RASGRP4	HPRD	empirical	11880369
HRAS	AGTR1	HPRD	empirical	8753867
HRAS	ZBTB12	HPRD	empirical	8939933
HRAS	IKZF3	HPRD, BioGRID	empirical	10369681
HRAS	ZHX2	BioGRID	empirical	17533377 11205744
HRAS	RGL1	HPRD, IntAct, BioGRID	empirical	10545207 20936779
HRAS	FNTA	HPRD, IntAct	empirical	2217184 15451670
HRAS	FNTB	HPRD	empirical	2217184 15451670
HRAS	ICMT	HPRD	empirical	12750467
HRAS	FYN	HPRD, MINT	empirical	12695509
HRAS	RGL4	HPRD	empirical	12874025 9154803
HRAS	ABL2	MINT, IntAct	empirical	15886098
HRAS	GRB2	HPRD	empirical	11352655
HRAS	RAPGEF1	HPRD	empirical	10514505
HRAS	GRIN1	HPRD, IntAct	empirical	10862698 16635246
HRAS	GRIN2B	IntAct	empirical	16635246
HRAS	GRIN2D	HPRD	empirical	10862698
HRAS	GPSM2	HPRD, BioGRID	empirical	12748287
HRAS	RHOD	HPRD	empirical	15187129
HRAS	APC	BioGRID	empirical	16478791
HRAS	IL3	HPRD	empirical	10677502
HRAS	INSR	HPRD, BioGRID	empirical	3109943
HRAS	IRAK1	HPRD	empirical	11744690
HRAS	IRAK2	HPRD	empirical	11744690
HRAS	ARAF	HPRD, IntAct	empirical	12620389 9488663
HRAS	KRT18	IntAct	empirical	21988832
HRAS	LGALS1	HPRD, BioGRID	empirical	11709720
HRAS	MLLT4	BioGRID	empirical	10922060 10334923
HRAS	NF1	HPRD, BioGRID	empirical	8628317
HRAS	PLCE1	HPRD	empirical	11022048
HRAS	PDE6D	HPRD, BioGRID	empirical	11980706 11786539
HRAS	PDGFB	HPRD	empirical	10485711
HRAS	PIK3CA	HPRD, IntAct, BioGRID	empirical	9150145 17540175 14724584 10783161 8665852
HRAS	PIK3CD	HPRD, IntAct, BioGRID	empirical	11739523 9113989 9235916 10922060
HRAS	PIK3CG	HPRD, MINT, IntAct, BioGRID	empirical	11136978
HRAS	PIK3R1	HPRD, IntAct, BioGRID	empirical	10212255 12196526 9150145
HRAS	PLAU	BioGRID	empirical	10402467
HRAS	TLR9	HPRD	empirical	12867418
HRAS	APBB1IP	MINT	empirical	15642358
HRAS	RASIP1	HPRD, BioGRID	empirical	15031288
HRAS	PRKCE	IntAct	empirical	11139474
HRAS	PRKCI	HPRD	empirical	10848576
HRAS	PRKCZ	HPRD	empirical	15721486
HRAS	ERBB2IP	BioGRID	empirical	12379659
HRAS	MAPK8	HPRD	empirical	8137421 11525649 16810318
HRAS	MAP2K1	HPRD, BioGRID	empirical	7969158
HRAS	RGL2	HPRD, IntAct, BioGRID	empirical	8939933 20936779 15031288
HRAS	RAF1	HPRD, MINT, IntAct, BioGRID	empirical	8530446 8911690 8035810 9099670 7730360 8332187 16301319 15688026 8332195 9154803 9261098 18273062 19063885 19222999 9144171 20178605 12620389 8670882 9488663 14654780 15031288 14724584 10783161 10882715 9523700 10922060 16803888 7862125 7969158 10369681 8628317 9150145 12379659
HRAS	RALA	MINT, BioGRID	empirical	19222999 11786539
HRAS	RALGDS	HPRD, IntAct, BioGRID	empirical	7972015 9038168 9628477 9144171 20936779 15031288 10783161 10922060 7809086 9150145 9154803
HRAS	RAP1B	HPRD	empirical	8332187
HRAS	RAP1GDS1	HPRD, BioGRID	empirical	11948427
HRAS	RARRES3	HPRD	empirical	16005186
HRAS	RASA1	HPRD, MINT, IntAct, BioGRID	empirical	7628625 9219684 2833817 8663024 11389730
HRAS	RASGRF1	BioGRID	empirical	9154803
HRAS	BCL2	HPRD	empirical	10490827
HRAS	RGS12	HPRD, MINT	empirical	17380122
HRAS	RHEB	BioGRID	empirical	15854902
HRAS	RIT2	HPRD	empirical	10545207
HRAS	ITSN1	HPRD	empirical	12970366
HRAS	SNRPE	BioGRID	empirical	9154803
HRAS	SOS1	HPRD, MINT, IntAct	empirical	11560935 9690470 9447984 17084389 12628188 15507210
HRAS	SOS2	HPRD	empirical	12628188
HRAS	SRC	HPRD, MINT	empirical	12695509
HRAS	BRAF	HPRD, MINT, BioGRID	empirical	7706312 16803888 9154803 8668348
HRAS	TIAM1	HPRD, BioGRID	empirical	12134164
HRAS	TLR2	HPRD	empirical	15496409
HRAS	TP73	HPRD	empirical	16436381
HRAS	TTC1	HPRD, BioGRID	empirical	12748287
HRAS	UBC	BioGRID	empirical	19240121
HRAS	VAV1	HPRD	empirical	8554611
HRAS	SHOC2	HPRD, IntAct, BioGRID	empirical	10783161 9674433 16301319
HRAS	BRAP	HPRD, IntAct	empirical	14724641
HRAS	RASSF5	HPRD, MINT, IntAct	empirical	9488663 18596699 11857081
HRAS	DGKZ	HPRD, BioGRID	empirical	11257115
HRAS	CAV1	HPRD, MINT	empirical	8621645
HRAS	BTRC	BioGRID	empirical	19240121
HRAS	ARHGEF1	BioGRID	empirical	12581858
HRAS	RIN1	HPRD, MINT, IntAct, BioGRID	empirical	9144171 7862125 15886098 15031288
HRAS	RASSF2	HPRD	empirical	12732644
HRAS	CDC25A	HPRD	empirical	7744247
HRAS	CDC25C	HPRD	empirical	9154803