APBB1

Summary Top Help

Gene Description:

amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta (A4) precursor protein-binding, family B, member 1

Synonyms:

RIR, MGC:9072, FE65, Apbb1, Rir, Fe65, APBB1

Orthologs:

Human APBB1 (protein-coding), Mouse Apbb1 (protein-coding), Rat Apbb1 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd27	Mouse	chr7:86521272..127029671	40.51	634

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:6416354..6440644 (24.29 kb) View in Genome Browser

(Mouse) NCBIM37 - chr7:112706998..112730049 (235 kb) View in Genome Browser

(Rat) RGSC3.4 - chr1:163282918..163299333 (16.41 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for APBB1:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for APBB1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 25

Publications from PubMed Top Help

Type 1 Diabetes Publications: 1

Publications: 124

Identification and characterization of a neuronal enriched novel transcript encoding the previously described p60Fe65 isoform.
Domingues SC, Henriques AG, Fardilha M, da Cruz E Silva EF, da Cruz E Silva OA
J Neurochem. 2011
PubMed ID: 21824145
Phosphorylation of LRP1 regulates the interaction with Fe65.
Klug W, Dietl A, Simon B, Sinning I, Wild K
FEBS Lett. 2011
PubMed ID: 21968187
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.
Mulvihill MM, Guttman M, Komives EA
Biochemistry. 2011
PubMed ID: 21650223
A role for FE65 in controlling GnRH-1 neurogenesis.
Forni PE, Fornaro M, Guénette S, Wray S
J Neurosci. 2011
PubMed ID: 21228158
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.
Alvira-Botero X, Pérez-Gonzalez R, Spuch C, Vargas T, Antequera D, Garzón M, Bermejo-Pareja F, Carro E
Mol Cell Neurosci. 2010
PubMed ID: 20637285
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing.
Kwon OY, Hwang K, Kim JA, Kim K, Kwon IC, Song HK, Jeon H
J Cell Biochem. 2010
PubMed ID: 20568118
The amyloid precursor protein intracellular domain(AICD) disrupts actin dynamics and mitochondrial bioenergetics.
Ward MW, Concannon CG, Whyte J, Walsh CM, Corley B, Prehn JH
J Neurochem. 2010
PubMed ID: 20405578
Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1.
Yu HT, Chan WW, Chai KH, Lee CW, Chang RC, Yu MS, McLoughlin DM, Miller CC, Lau KF
J Cell Biochem. 2010
PubMed ID: 20091743
Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells.
Kawai T, Nakaya T, Suzuki T
FEBS Lett. 2010
PubMed ID: 20036665
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo.
Barbagallo AP, Weldon R, Tamayev R, Zhou D, Giliberto L, Foreman O, D'Adamio L
PLoS One. 2010
PubMed ID: 21103325
A flanking gene problem leads to the discovery of a Gprc5b splice variant predominantly expressed in C57Bl/6J mouse brain and in maturing neurons.
Cool BH, Chan GC, Lee L, Oshima J, Martin GM, Hu Q
PLoS One. 2010
PubMed ID: 20436672
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells.
Nakaya T, Kawai T, Suzuki T
FEBS J. 2009
PubMed ID: 19796171
Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures.
Henriques AG, Vieira SI, da Cruz e Silva EF, da Cruz e Silva OA
J Mol Neurosci. 2009
PubMed ID: 19340611
Ubiquitylation of Fe65 adaptor protein by neuronal precursor cell expressed developmentally down regulated 4-2 (Nedd4-2) via the WW domain interaction with Fe65.
Lee EJ, Hyun S, Chun J, Shin SH, Kang SS
Exp Mol Med. 2009
PubMed ID: 19381069
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG
Nature. 2009
PubMed ID: 19234442
Fe65 is required for Tip60-directed histone H4 acetylation at DNA strand breaks.
Stante M, Minopoli G, Passaro F, Raia M, Vecchio LD, Russo T
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19282473
The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation.
Wang Y, Zhang M, Moon C, Hu Q, Wang B, Martin G, Sun Z, Wang H
Learn Mem. 2009
PubMed ID: 19713352
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.
Kajiwara Y, Akram A, Katsel P, Haroutunian V, Schmeidler J, Beecham G, Haines JL, Pericak-Vance MA, Buxbaum JD
PLoS One. 2009
PubMed ID: 19343227
Epigallocatechin gallate (EGCG) suppresses beta-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3 beta activation.
Lin CL, Chen TF, Chiu MJ, Way TD, Lin JK
Neurobiol Aging. 2009
PubMed ID: 17590240
Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription.
Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC
J Biol Chem. 2008
PubMed ID: 18922798
A differential proteomic approach reveals an evolutionary conserved regulation of Nme proteins by Fe65 in C. elegans and mouse.
Napolitano F, D'Angelo F, Bimonte M, Perrina V, D'Ambrosio C, Scaloni A, Russo T, Zambrano N
Neurochem Res. 2008
PubMed ID: 18401706
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Radzimanowski J, Simon B, Sattler M, Beyreuther K, Sinning I, Wild K
EMBO Rep. 2008
PubMed ID: 18833287
Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis.
Carlson ES, Magid R, Petryk A, Georgieff MK
Brain Res. 2008
PubMed ID: 18723004
Association of amyloid precursor protein-binding protein, family B, member 1 with nicotine dependence in African and European American smokers.
Chen GB, Payne TJ, Lou XY, Ma JZ, Zhu J, Li MD
Hum Genet. 2008
PubMed ID: 18777128
Crystal structure of the human Fe65-PTB1 domain.
Radzimanowski J, Ravaud S, Schlesinger S, Koch J, Beyreuther K, Sinning I, Wild K
J Biol Chem. 2008
PubMed ID: 18550529
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Krause K, Karger S, Sheu SY, Aigner T, Kursawe R, Gimm O, Schmid KW, Dralle H, Fuhrer D
J Endocrinol. 2008
PubMed ID: 18480379
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.
Nakaya T, Kawai T, Suzuki T
J Biol Chem. 2008
PubMed ID: 18468999
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.
Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC
Nat Cell Biol. 2008
PubMed ID: 18278038
Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue.
Lee EJ, Chun J, Hyun S, Ahn HR, Jeong JM, Hong SK, Hong JT, Chang IK, Jeon HY, Han YS, Auh CK, Park JI, Kang SS
BMB Rep. 2008
PubMed ID: 18304449
Amyloid oligomer conformation in a group of natively folded proteins.
Yoshiike Y, Minai R, Matsuo Y, Chen YR, Kimura T, Takashima A
PLoS ONE. 2008
PubMed ID: 18800165
Meta-analysis of genetic variability in the beta-amyloid production, aggregation and degradation metabolic pathways and the risk of Alzheimer's disease.
Llorca J, Rodríguez-Rodríguez E, Dierssen-Sotos T, Delgado-Rodríguez M, Berciano J, Combarros O
Acta Neurol Scand. 2008
PubMed ID: 17854420
Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
Wiley JC, Smith EA, Hudson MP, Ladiges WC, Bothwell M
J Biol Chem. 2007
PubMed ID: 17855370
Structural basis for polyproline recognition by the FE65 WW domain.
Meiyappan M, Birrane G, Ladias JA
J Mol Biol. 2007
PubMed ID: 17686488
Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins.
Lee EJ, Hyun SH, Chun J, Kang SS
Biochem Biophys Res Commun. 2007
PubMed ID: 17512906
Notch1 intracellular domain suppresses APP intracellular domain-Tip60-Fe65 complex mediated signaling through physical interaction.
Kim SY, Kim MY, Mo JS, Park HS
Biochim Biophys Acta. 2007
PubMed ID: 17368826
A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching.
Ikin AF, Sabo SL, Lanier LM, Buxbaum JD
Mol Cell Neurosci. 2007
PubMed ID: 17383198
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, Kobayashi H, Ishikawa HO, Ohsugi Y, Yamamoto T, Matsuno K, Kinjo M, Suzuki T
EMBO J. 2007
PubMed ID: 17332754
Suppression of beta-amyloid precursor protein signaling into the nucleus by estrogens mediated through complex formation between the estrogen receptor and Fe65.
Bao J, Cao C, Zhang X, Jiang F, Nicosia SV, Bai W
Mol Cell Biol. 2007
PubMed ID: 17130235
Essential roles for Fe65, Alzheimer amyloid precursor-binding protein, in the cellular response to DNA damage.
Minopoli G, Stante M, Napolitano F, Telese F, Aloia L, De Felice M, Di Lauro R, Pacelli R, Brunetti A, Zambrano N, Russo T
J Biol Chem. 2007
PubMed ID: 17121854
FE65 interaction with the ApoE receptor ApoEr2.
Hoe HS, Magill LA, Guenette S, Fu Z, Vicini S, Rebeck GW
J Biol Chem. 2006
PubMed ID: 16638748
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD.
Nakaya T, Suzuki T
Genes Cells. 2006
PubMed ID: 16716194
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
Human chromosome 11 DNA sequence and analysis including novel gene identification.
Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y
Nature. 2006
PubMed ID: 16554811
A dominant role for FE65 (APBB1) in nuclear signaling.
Yang Z, Cool BH, Martin GM, Hu Q
J Biol Chem. 2006
PubMed ID: 16332686
Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function.
Masin M, Kerschensteiner D, Dümke K, Rubio ME, Soto F
J Biol Chem. 2006
PubMed ID: 16330549
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
Guénette S, Chang Y, Hiesberger T, Richardson JA, Eckman CB, Eckman EA, Hammer RE, Herz J
EMBO J. 2006
PubMed ID: 16407979
Role of 14-3-3gamma in FE65-dependent gene transactivation mediated by the amyloid beta-protein precursor cytoplasmic fragment.
Sumioka A, Nagaishi S, Yoshida T, Lin A, Miura M, Suzuki T
J Biol Chem. 2005
PubMed ID: 16223726
Probing the secondary structure of a recombinant neuronal adaptor protein and its phosphotyrosine binding domains.
Lamberti A, Longo O, Del Vecchio P, Zambrano N, Barone G, Russo T, Arcari P
Biosci Biotechnol Biochem. 2005
PubMed ID: 16377899
Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.
Muresan Z, Muresan V
J Cell Biol. 2005
PubMed ID: 16301330
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
WW domains provide a platform for the assembly of multiprotein networks.
Ingham RJ, Colwill K, Howard C, Dettwiler S, Lim CS, Yu J, Hersi K, Raaijmakers J, Gish G, Mbamalu G, Taylor L, Yeung B, Vassilovski G, Amin M, Chen F, Matskova L, Winberg G, Ernberg I, Linding R, O'donnell P, Starostine A, Keller W, Metalnikov P, Stark C, Pawson T
Mol Cell Biol. 2005
PubMed ID: 16055720
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE
Ann Neurol. 2005
PubMed ID: 16049941
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Pardossi-Piquard R, Petit A, Kawarai T, Sunyach C, Alves da Costa C, Vincent B, Ring S, D'Adamio L, Shen J, Müller U, St George Hyslop P, Checler F
Neuron. 2005
PubMed ID: 15944124
Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.
Santiard-Baron D, Langui D, Delehedde M, Delatour B, Schombert B, Touchet N, Tremp G, Paul MF, Blanchard V, Sergeant N, Delacourte A, Duyckaerts C, Pradier L, Mercken L
J Neurochem. 2005
PubMed ID: 15816856
Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates.
Hu Q, Wang L, Yang Z, Cool BH, Zitnik G, Martin GM
J Biol Chem. 2005
PubMed ID: 15647266
Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.
Telese F, Bruni P, Donizetti A, Gianni D, D'Ambrosio C, Scaloni A, Zambrano N, Rosenfeld MG, Russo T
EMBO Rep. 2005
PubMed ID: 15592452
Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.
Frederikse PH, Yun E, Kao HT, Zigler JS, Sun Q, Qazi AS
Mol Vis. 2004
PubMed ID: 15529118
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.
Cao X, Südhof TC
J Biol Chem. 2004
PubMed ID: 15044485
Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T
J Biol Chem. 2004
PubMed ID: 15037614
Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA
Nat Biotechnol. 2004
PubMed ID: 15146195
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
Perkinton MS, Standen CL, Lau KF, Kesavapany S, Byers HL, Ward M, McLoughlin DM, Miller CC
J Biol Chem. 2004
PubMed ID: 15031292
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Isoform-specific knockout of FE65 leads to impaired learning and memory.
Wang B, Hu Q, Hearn MG, Shimizu K, Ware CB, Liggitt DH, Jin LW, Cool BH, Storm DR, Martin GM
J Neurosci Res. 2004
PubMed ID: 14689444
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W
Neurobiol Dis. 2003
PubMed ID: 14572442
Proposed pathogenetic cascade of inclusion-body myositis: importance of amyloid-beta, misfolded proteins, predisposing genes, and aging.
Askanas V, Engel WK
Curr Opin Rheumatol. 2003
PubMed ID: 14569203
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
Kinoshita A, Shah T, Tangredi MM, Strickland DK, Hyman BT
J Biol Chem. 2003
PubMed ID: 12888553
The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo.
Sabo SL, Ikin AF, Buxbaum JD, Greengard P
J Neurosci. 2003
PubMed ID: 12843239
gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ
Biochemistry. 2003
PubMed ID: 12779321
Real-time PCR quantitation of FE65 a beta-amyloid precursor protein-binding protein after traumatic brain injury in rats.
Iino M, Nakatome M, Ogura Y, Fujimura H, Kuroki H, Inoue H, Ino Y, Fujii T, Terao T, Matoba R
Int J Legal Med. 2003
PubMed ID: 12707777
A risk for early-onset Alzheimer's disease associated with the APBB1 gene (FE65) intron 13 polymorphism.
Cousin E, Hannequin D, Ricard S, Macé S, Génin E, Chansac C, Brice A, Dubois B, Frebourg T, Mercken L, Benavides J, Pradier L, Campion D, Deleuze JF
Neurosci Lett. 2003
PubMed ID: 12727304
The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway.
Zhao Q, Lee FS
Biochemistry. 2003
PubMed ID: 12653567
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression.
Bruni P, Minopoli G, Brancaccio T, Napolitano M, Faraonio R, Zambrano N, Hansen U, Russo T
J Biol Chem. 2002
PubMed ID: 12089154
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.
Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG
Cell. 2002
PubMed ID: 12150997
A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type.
Hu Q, Cool BH, Wang B, Hearn MG, Martin GM
Hum Mol Genet. 2002
PubMed ID: 11854179
Expression of the Fe65 adapter protein in adult and developing mouse brain.
Kesavapany S, Banner SJ, Lau KF, Shaw CE, Miller CC, Cooper JD, McLoughlin DM
Neuroscience. 2002
PubMed ID: 12435432
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O
FEBS Lett. 2001
PubMed ID: 11741599
Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.
Kinoshita A, Whelan CM, Smith CJ, Mikhailenko I, Rebeck GW, Strickland DK, Hyman BT
J Neurosci. 2001
PubMed ID: 11606623
The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.
Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ
J Biol Chem. 2001
PubMed ID: 11544248
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
Cao X, Südhof TC
Science. 2001
PubMed ID: 11441186
The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M, Russo T
J Biol Chem. 2001
PubMed ID: 11279131
Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease.
Prince JA, Feuk L, Sawyer SL, Gottfries J, Ricksten A, Nägga K, Bogdanovic N, Blennow K, Brookes AJ
Eur J Hum Genet. 2001
PubMed ID: 11436125
The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity.
McLoughlin DM, Standen CL, Lau KF, Ackerley S, Bartnikas TP, Gitlin JD, Miller CC
J Biol Chem. 2001
PubMed ID: 11115513
The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation.
Minopoli G, de Candia P, Bonetti A, Faraonio R, Zambrano N, Russo T
J Biol Chem. 2001
PubMed ID: 11085987
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Guénette SY, Bertram L, Crystal A, Bakondi B, Hyman BT, Rebeck GW, Tanzi RE, Blacker D
Neurosci Lett. 2000
PubMed ID: 11099823
cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains.
Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB
J Biol Chem. 2000
PubMed ID: 10945997
Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein.
Lau KF, McLoughlin DM, Standen CL, Irving NG, Miller CC
Neuroreport. 2000
PubMed ID: 11095528
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
No association between an intronic biallelic polymorphism of the FE65 gene and Alzheimer's disease.
Papassotiropoulos A, Bagli M, Becker K, Jessen F, Maier W, Rao ML, Ludwig M, Heun R
Int J Mol Med. 2000
PubMed ID: 11029529
A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains.
Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin MC
Neurosci Lett. 2000
PubMed ID: 11065130
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers.
Hu Q, Hearn MG, Jin LW, Bressler SL, Martin GM
J Neurosci Res. 1999
PubMed ID: 10561691
Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein.
Sabo SL, Lanier LM, Ikin AF, Khorkova O, Sahasrabudhe S, Greengard P, Buxbaum JD
J Biol Chem. 1999
PubMed ID: 10075692
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.
Tanahashi H, Tabira T
Neurosci Lett. 1999
PubMed ID: 10081969
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.
Trommsdorff M, Borg JP, Margolis B, Herz J
J Biol Chem. 1998
PubMed ID: 9837937
The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type.
Hu Q, Kukull WA, Bressler SL, Gray MD, Cam JA, Larson EB, Martin GM, Deeb SS
Hum Genet. 1998
PubMed ID: 9799084
Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein.
Russo T, Faraonio R, Minopoli G, De Candia P, De Renzis S, Zambrano N
FEBS Lett. 1998
PubMed ID: 9738440
The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1.
Zambrano N, Minopoli G, de Candia P, Russo T
J Biol Chem. 1998
PubMed ID: 9685356
Mapping of the human and murine X11-like genes (APBA2 and apba2), the murine Fe65 gene (Apbb1), and the human Fe65-like gene (APBB2): genes encoding phosphotyrosine-binding domain proteins that interact with the Alzheimer's disease amyloid precursor prote
Blanco G, Irving NG, Brown SD, Miller CC, McLoughlin DM
Mamm Genome. 1998
PubMed ID: 9585438
Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.
Pappolla MA, Chyan YJ, Omar RA, Hsiao K, Perry G, Smith MA, Bozner P
Am J Pathol. 1998
PubMed ID: 9546346
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
Duilio A, Faraonio R, Minopoli G, Zambrano N, Russo T
Biochem J. 1998
PubMed ID: 9461550
The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.
Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M
J Biol Chem. 1997
PubMed ID: 9407065
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins.
Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T
J Biol Chem. 1997
PubMed ID: 9045663
The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system.
McLoughlin DM, Miller CC
FEBS Lett. 1996
PubMed ID: 8955346
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Borg JP, Ooi J, Levy E, Margolis B
Mol Cell Biol. 1996
PubMed ID: 8887653
cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM
Hum Mol Genet. 1996
PubMed ID: 8894693
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
Guénette SY, Chen J, Jondro PD, Tanzi RE
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8855266
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.
Fiore F, Zambrano N, Minopoli G, Donini V, Duilio A, Russo T
J Biol Chem. 1995
PubMed ID: 8537337
The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription.
Faraonio R, Minopoli G, Porcellini A, Costanzo F, Cimino F, Russo T
Nucleic Acids Res. 1994
PubMed ID: 7800475
Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives.
Simeone A, Duilio A, Fiore F, Acampora D, De Felice C, Faraonio R, Paolocci F, Cimino F, Russo T
Dev Neurosci. 1994
PubMed ID: 7867517
A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases.
Duilio A, Zambrano N, Mogavero AR, Ammendola R, Cimino F, Russo T
Nucleic Acids Res. 1991
PubMed ID: 1923810

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	322	11785	29722
EnsEMBL Gene(s)	ENSG00000166313	ENSMUSG00000037032	ENSRNOG00000018020
Unigene	Hs.372840	Mm.38469	Rn.19953
Homologene	APBB1	Apbb1	Apbb1
OMIM	602709	N/A	N/A
GeneCards	APBB1	N/A	N/A
Beta Cell Genomics	DT.100030228 DT.100757200 DT.100792900 DT.100800233 DT.100835677 DT.447981	DT.101736491 DT.101736492 DT.491464 DT.99864594	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	322	11785	29722

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
APBB1	ABI1	BioGRID	empirical	16055720
APBB1	PQBP1	BioGRID	empirical	16055720
APBB1	TSHZ1	BioGRID	empirical	19343227
APBB1	SF3B4	BioGRID	empirical	16055720
APBB1	SF3A1	BioGRID	empirical	16055720
APBB1	DDX17	BioGRID	empirical	16055720
APBB1	KAT5	HPRD	empirical	11441186
APBB1	KHDRBS1	BioGRID	empirical	16055720
APBB1	SF3A3	BioGRID	empirical	16055720
APBB1	SF3B2	BioGRID	empirical	16055720
APBB1	CPSF6	BioGRID	empirical	16055720
APBB1	U2AF2	BioGRID	empirical	16055720
APBB1	TSHZ2	BioGRID	empirical	19343227
APBB1	WIPF2	BioGRID	empirical	16055720
APBB1	DDX3X	BioGRID	empirical	16055720
APBB1	DHX9	BioGRID	empirical	16055720
APBB1	DIAPH1	BioGRID	empirical	16055720
APBB1	DIAPH2	BioGRID	empirical	16055720
APBB1	EGFR	MINT	empirical	16273093
APBB1	ERBB2	MINT	empirical	16273093
APBB1	CLSTN1	HPRD, MINT	empirical	15037614 17332754
APBB1	NEDD4L	BioGRID	empirical	19381069
APBB1	SF3B1	BioGRID	empirical	16055720
APBB1	ABL1	HPRD, MINT	empirical	11279131
APBB1	PABPC1	BioGRID	empirical	16055720
APBB1	CYFIP2	BioGRID	empirical	16055720
APBB1	HTATSF1	BioGRID	empirical	16055720
APBB1	ANXA1	BioGRID	empirical	21900206
APBB1	HDAC1	BioGRID	empirical	19343227
APBB1	HNRNPH1	BioGRID	empirical	16055720
APBB1	HNRNPK	BioGRID	empirical	16055720
APBB1	APBB1	HPRD	empirical	9407065
APBB1	APLP1	HPRD, BioGRID	empirical	8894693 10081969
APBB1	APLP2	HPRD, IntAct	empirical	8894693 9461550
APBB1	APP	HPRD, MINT, IntAct, BioGRID	empirical	8887653 8955346 9799084 9837937 11085987 9045663 11517249 9461550 16049941 8855266 10081969 8894693
APBB1	FASLG	HPRD	empirical	11741599
APBB1	LRP1	HPRD, BioGRID	empirical	9837937
APBB1	LRP2	HPRD	empirical	9837937
APBB1	NONO	BioGRID	empirical	16055720
APBB1	YBX1	BioGRID	empirical	16055720
APBB1	EVL	HPRD, BioGRID	empirical	10945997 16055720
APBB1	WBP11	BioGRID	empirical	16055720
APBB1	ENAH	HPRD, MIPS, BioGRID	empirical	9407065 16055720
APBB1	PRNP	HPRD, MINT	empirical	15146195
APBB1	YLPM1	BioGRID	empirical	16055720
APBB1	PTBP1	BioGRID	empirical	16055720
APBB1	TSHZ3	BioGRID	empirical	19343227
APBB1	RPL4	BioGRID	empirical	16055720
APBB1	ATXN1	HPRD, MINT, IntAct	empirical	16713569
APBB1	SET	BioGRID	empirical	15592452
APBB1	SFPQ	BioGRID	empirical	16055720
APBB1	TFCP2	HPRD, BioGRID	empirical	9685356
APBB1	UBC	BioGRID	empirical	19381069 21139048 21890473
APBB1	VASP	HPRD, BioGRID	empirical	16055720
APBB1	WAS	BioGRID	empirical	16055720
APBB1	WIPF1	BioGRID	empirical	16055720
APBB1	SF1	BioGRID	empirical	16055720
APBB1	CPSF7	BioGRID	empirical	16055720
APBB1	SF3A2	BioGRID	empirical	16055720
APBB1	RBM17	BioGRID	empirical	16055720
APBB1	WASL	BioGRID	empirical	16055720
APBB1	CCDC97	BioGRID	empirical	16055720
APBB1	DDX46	BioGRID	empirical	16055720
APBB1	THRAP3	BioGRID	empirical	16055720