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HOXA9

Gene Description:   homeobox A9 Synonyms:   MGC1934, HOXA9, Hox-1.7, Hoxa7, D6a9, HOX1.7, HOX1G, HOX1, Hoxa9, Hox1r5, ABD-B Orthologs:   Human HOXA9 (protein-coding), Mouse Hoxa9 (protein-coding), Rat Hoxa9 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Human-Rat: HomoloGene, MGD, RGD Mouse-Rat: HomoloGene, MGD, RGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 2

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
7p15.2	Human	chr7:26657962..27205282	0.55	75	rs7804356

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	829
Human 7p15.2 Orthologous Region	Mouse	chr6:51768205..52199869	0.43	14
Human 7p15.2 Orthologous Region	Rat	chr4:80112734..80552452	0.44	10

(Human) GRCh37 - chr7:27202057..27209269 (7.21 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr6:52173099..52181088 (7.99 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr4:80515622..80517521 (1.90 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HOXA9: The HOXA9 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HOXA9   RBPMS   HPRD, MINT, IntAct, BioGRID  empirical  16189514  HOXA9   GTF2A1L   BioGRID  empirical  20211142  HOXA9   CREBBP   HPRD  empirical  15161102  HOXA9   PDXDC1   Sanger Interaction Map  predicted  15345047  HOXA9   JUN   HPRD, BioGRID  empirical  11551904  HOXA9   SMAD2   HPRD  empirical  11042172  HOXA9   SMAD4   HPRD, BioGRID  empirical  11042172  HOXA9   MEIS1   HPRD, IntAct, BioGRID  empirical  10082572  15161102  15617687  9343407  HOXA9   MEIS2   HPRD  empirical  15161102  HOXA9   NFKBIA   HPRD  empirical  15161102  HOXA9   PAX6   BioGRID  empirical  20211142  HOXA9   PBX1   HPRD, MINT, BioGRID  empirical  10082572  15161102  12923056  HOXA9   PBX2   HPRD, BioGRID  empirical  10082572  HOXA9   PBX3   HPRD, BioGRID  empirical  10082572  20211142  HOXA9   PLSCR1   HPRD, MINT, IntAct, BioGRID  empirical  16189514  HOXA9   POLR2I   BioGRID  empirical  20211142  HOXA9   POU2F1   BioGRID  empirical  20211142  HOXA9   BCR   BioGRID  empirical  12393433  HOXA9   NKX2-1   BioGRID  empirical  20211142  HOXA9   TRIP6   HPRD, MINT, IntAct, BioGRID  empirical  16189514  19060904  HOXA9   PHF17   BioGRID  empirical  20211142

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 5   Sequence-specific DNA binding transcription factor activity GO:0003700 Protein binding GO:0005515 Nucleus GO:0005634 Multicellular organismal development GO:0007275 Sequence-specific DNA binding GO:0043565

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 5 Sequence-specific DNA binding transcription factor activity GO:0003700 Protein binding GO:0005515 Nucleus GO:0005634 Multicellular organismal development GO:0007275 Sequence-specific DNA binding GO:0043565

Publications: 151

• Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells.
  Smith LL, Yeung J, Zeisig BB, Popov N, Huijbers I, Barnes J, Wilson AJ, Taskesen E, Delwel R, Gil J, Van Lohuizen M, So CW
  Cell Stem Cell. 2011
  PubMed ID: 21624810
   
  
• Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.
  Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21518888
   
  
• Detection of HOXA9 gene methylation in tumor tissues and induced sputum samples from primary lung cancer patients.
  Hwang SH, Kim KU, Kim JE, Kim HH, Lee MK, Lee CH, Lee SY, Oh T, An S
  Clin Chem Lab Med. 2011
  PubMed ID: 21480815
   
  
• Axial Hox9 activity establishes the posterior field in the developing forelimb.
  Xu B, Wellik DM
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21383175
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
  Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
  Gene Expr Patterns. 2011
  PubMed ID: 20932939
   
  
• Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.
  Gwin K, Frank E, Bossou A, Medina KL
  J Immunol. 2010
  PubMed ID: 20971928
   
  
• MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.
  Gaspar N, Marshall L, Perryman L, Bax DA, Little SE, Viana-Pereira M, Sharp SY, Vassal G, Pearson AD, Reis RM, Hargrave D, Workman P, Jones C
  Cancer Res. 2010
  PubMed ID: 20935218
   
  
• Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
  Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS
  Neuron. 2010
  PubMed ID: 20826310
   
  
• Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
  Mol Med. 2010
  PubMed ID: 20379614
   
  
• Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis.
  Milne TA, Kim J, Wang GG, Stadler SC, Basrur V, Whitcomb SJ, Wang Z, Ruthenburg AJ, Elenitoba-Johnson KS, Roeder RG, Allis CD
  Mol Cell. 2010
  PubMed ID: 20541448
   
  
• HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype.
  Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM
  J Clin Invest. 2010
  PubMed ID: 20389018
   
  
• Co-expression of HoxA9 and bcr-abl genes in chronic myeloid leukemia.
  Tedeschi FA, Cardozo MA, Valentini R, Zalazar FE
  Leuk Lymphoma. 2010
  PubMed ID: 20141430
   
  
• An atlas of combinatorial transcriptional regulation in mouse and man.
  Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
  Cell. 2010
  PubMed ID: 20211142
   
  
• Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma.
  Costa BM, Smith JS, Chen Y, Chen J, Phillips HS, Aldape KD, Zardo G, Nigro J, James CD, Fridlyand J, Reis RM, Costello JF
  Cancer Res. 2010
  PubMed ID: 20068170
   
  
• BRCA1: linking HOX to breast cancer suppression.
  Jin K, Sukumar S
  Breast Cancer Res. 2010
  PubMed ID: 20727230
   
  
• Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines.
  Nagel S, Venturini L, Marquez VE, Meyer C, Kaufmann M, Scherr M, MacLeod RA, Drexler HG
  Mol Cancer. 2010
  PubMed ID: 20565746
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
  Ester AR, Weymouth KS, Burt A, Wise CA, Scott A, Gurnett CA, Dobbs MB, Blanton SH, Hecht JT
  Am J Med Genet A. 2009
  PubMed ID: 19938081
   
  
• Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation.
  Ono R, Kumagai H, Nakajima H, Hishiya A, Taki T, Horikawa K, Takatsu K, Satoh T, Hayashi Y, Kitamura T, Nosaka T
  Leukemia. 2009
  PubMed ID: 19710696
   
  
• HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis.
  Hu YL, Fong S, Ferrell C, Largman C, Shen WF
  Mol Cell Biol. 2009
  PubMed ID: 19620287
   
  
• In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.
  Novotny E, Compton S, Liu PP, Collins FS, Chandrasekharappa SC
  Mech Dev. 2009
  PubMed ID: 19393316
   
  
• Gfi1 integrates progenitor versus granulocytic transcriptional programming.
  Horman SR, Velu CS, Chaubey A, Bourdeau T, Zhu J, Paul WE, Gebelein B, Grimes HL
  Blood. 2009
  PubMed ID: 19346496
   
  
• A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
  Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
  J Bone Miner Res. 2009
  PubMed ID: 19453261
   
  
• HOXA9 is required for survival in human MLL-rearranged acute leukemias.
  Faber J, Krivtsov AV, Stubbs MC, Wright R, Davis TN, van den Heuvel-Eibrink M, Zwaan CM, Kung AL, Armstrong SA
  Blood. 2009
  PubMed ID: 19056693
   
  
• Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.
  Dickson GJ, Kwasniewska A, Mills KI, Lappin TR, Thompson A
  Exp Hematol. 2009
  PubMed ID: 19157684
   
  
• Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5.
  Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Döhner K, Döhner H, Weber O, Blum C, Rodewald HR, Sassone-Corsi P, Peters AH, Fehling HJ
  Blood. 2009
  PubMed ID: 18952892
   
  
• Dissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9.
  Yassin ER, Sarma NJ, Abdul-Nabi AM, Dombrowski J, Han Y, Takeda A, Yaseen NR
  PLoS One. 2009
  PubMed ID: 19696924
   
  
• Quantification of Hox and surfactant protein-B transcription during murine lung development.
  Grier DG, Thompson A, Lappin TR, Halliday HL
  Neonatology. 2009
  PubMed ID: 19204410
   
  
• An empirical framework for binary interactome mapping.
  Venkatesan K, Rual JF, Vazquez A, Stelzl U, Lemmens I, Hirozane-Kishikawa T, Hao T, Zenkner M, Xin X, Goh KI, Yildirim MA, Simonis N, Heinzmann K, Gebreab F, Sahalie JM, Cevik S, Simon C, de Smet AS, Dann E, Smolyar A, Vinayagam A, Yu H, Szeto D, Borick H, Dricot A, Klitgord N, Murray RR, Lin C, Lalowski M, Timm J, Rau K, Boone C, Braun P, Cusick ME, Roth FP, Hill DE, Tavernier J, Wanker EE, Barabási AL, Vidal M
  Nat Methods. 2009
  PubMed ID: 19060904
   
  
• HOX expression patterns identify a common signature for favorable AML.
  Andreeff M, Ruvolo V, Gadgil S, Zeng C, Coombes K, Chen W, Kornblau S, Barón AE, Drabkin HA
  Leukemia. 2008
  PubMed ID: 18668134
   
  
• Evidence for Hox and E2A-PBX1 collaboration in mouse T-cell leukemia.
  Bijl J, Krosl J, Lebert-Ghali CE, Vacher J, Mayotte N, Sauvageau G
  Oncogene. 2008
  PubMed ID: 18679416
   
  
• The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
  Dorrance AM, Liu S, Chong A, Pulley B, Nemer D, Guimond M, Yuan W, Chang D, Whitman SP, Marcucci G, Caligiuri MA
  Blood. 2008
  PubMed ID: 18617636
   
  
• Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia.
  Grubach L, Juhl-Christensen C, Rethmeier A, Olesen LH, Aggerholm A, Hokland P, Ostergaard M
  Eur J Haematol. 2008
  PubMed ID: 18410541
   
  
• MicroRNA-126 regulates HOXA9 by binding to the homeobox.
  Shen WF, Hu YL, Uttarwar L, Passegue E, Largman C
  Mol Cell Biol. 2008
  PubMed ID: 18474618
   
  
• HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia.
  Whelan JT, Ludwig DL, Bertrand FE
  Leukemia. 2008
  PubMed ID: 18337761
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9.
  Trivedi CM, Patel RC, Patel CV
  Gene. 2008
  PubMed ID: 18068911
   
  
• Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia.
  Keeshan K, Shestova O, Ussin L, Pear WS
  Blood Cells Mol Dis. 2008
  PubMed ID: 17988908
   
  
• Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium.
  Trivedi CM, Patel RC, Patel CV
  Atherosclerosis. 2007
  PubMed ID: 17586512
   
  
• Reduced number of circulating endothelial progenitors and HOXA9 expression in CD34+ cells of hypertensive patients.
  Pirro M, Schillaci G, Menecali C, Bagaglia F, Paltriccia R, Vaudo G, Mannarino MR, Mannarino E
  J Hypertens. 2007
  PubMed ID: 17885552
   
  
• Hoxa9/hoxb3/hoxb4 compound null mice display severe hematopoietic defects.
  Magnusson M, Brun AC, Lawrence HJ, Karlsson S
  Exp Hematol. 2007
  PubMed ID: 17761289
   
  
• Hox patterning of the vertebrate rib cage.
  McIntyre DC, Rakshit S, Yallowitz AR, Loken L, Jeannotte L, Capecchi MR, Wellik DM
  Development. 2007
  PubMed ID: 17626057
   
  
• HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells.
  Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE
  Mol Cell Biol. 2007
  PubMed ID: 17452460
   
  
• Evidence that the Pim1 kinase gene is a direct target of HOXA9.
  Hu YL, Passegué E, Fong S, Largman C, Lawrence HJ
  Blood. 2007
  PubMed ID: 17327400
   
  
• Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
  Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R
  Genes Cells. 2007
  PubMed ID: 17535249
   
  
• Identification of a new type of PBX1 partner that contains zinc finger motifs and inhibits the binding of HOXA9-PBX1 to DNA.
  Laurent A, Bihan R, Deschamps S, Guerrier D, Dupé V, Omilli F, Burel A, Pellerin I
  Mech Dev. 2007
  PubMed ID: 17353115
   
  
• DNA methylation profiling of ovarian carcinomas and their in vitro models identifies HOXA9, HOXB5, SCGB3A1, and CRABP1 as novel targets.
  Wu Q, Lothe RA, Ahlquist T, Silins I, Tropé CG, Micci F, Nesland JM, Suo Z, Lind GE
  Mol Cancer. 2007
  PubMed ID: 17623056
   
  
• Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation.
  Chung KY, Morrone G, Schuringa JJ, Plasilova M, Shieh JH, Zhang Y, Zhou P, Moore MA
  Cancer Res. 2006
  PubMed ID: 17178874
   
  
• HOXA9 gene expression in the chronic myeloid leukemia progression.
  Tedeschi FA, Zalazar FE
  Leuk Res. 2006
  PubMed ID: 16630659
   
  
• Age- and training-dependent development of arrhythmogenic right ventricular cardiomyopathy in heterozygous plakoglobin-deficient mice.
  Kirchhof P, Fabritz L, Zwiener M, Witt H, Schäfers M, Zellerhoff S, Paul M, Athai T, Hiller KH, Baba HA, Breithardt G, Ruiz P, Wichter T, Levkau B
  Circulation. 2006
  PubMed ID: 17030684
   
  
• Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations.
  Dorrance AM, Liu S, Yuan W, Becknell B, Arnoczky KJ, Guimond M, Strout MP, Feng L, Nakamura T, Yu L, Rush LJ, Weinstein M, Leone G, Wu L, Ferketich A, Whitman SP, Marcucci G, Caligiuri MA
  J Clin Invest. 2006
  PubMed ID: 16981007
   
  
• A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
  Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
  Development. 2006
  PubMed ID: 16971476
   
  
• The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice.
  Kong CT, Sham MH, So CW, Cheah KS, Chen SJ, Chan LC
  Leukemia. 2006
  PubMed ID: 16888613
   
  
• A group 13 homeodomain is neither necessary nor sufficient for posterior prevalence in the mouse limb.
  Williams ME, Lehoczky JA, Innis JW
  Dev Biol. 2006
  PubMed ID: 16806154
   
  
• Molecular dissection of Meis1 reveals 2 domains required for leukemia induction and a key role for Hoxa gene activation.
  Mamo A, Krosl J, Kroon E, Bijl J, Thompson A, Mayotte N, Girard S, Bisaillon R, Beslu N, Featherstone M, Sauvageau G
  Blood. 2006
  PubMed ID: 16469876
   
  
• c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells.
  Hess JL, Bittner CB, Zeisig DT, Bach C, Fuchs U, Borkhardt A, Frampton J, Slany RK
  Blood. 2006
  PubMed ID: 16507773
   
  
• Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression.
  Capellini TD, Di Giacomo G, Salsi V, Brendolan A, Ferretti E, Srivastava D, Zappavigna V, Selleri L
  Development. 2006
  PubMed ID: 16672333
   
  
• MOZ is essential for maintenance of hematopoietic stem cells.
  Katsumoto T, Aikawa Y, Iwama A, Ueda S, Ichikawa H, Ochiya T, Kitabayashi I
  Genes Dev. 2006
  PubMed ID: 16702405
   
  
• A subgroup of HOX Abd-B gene is differentially expressed in cervical cancer.
  López R, Garrido E, Vázquez G, Piña P, Pérez C, Alvarado I, Salcedo M
  Int J Gynecol Cancer. 2006
  PubMed ID: 16803519
   
  
• Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes.
  Wang GG, Pasillas MP, Kamps MP
  Mol Cell Biol. 2006
  PubMed ID: 16648484
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
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• Radial glia cells are candidate stem cells of ependymoma.
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• Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development.
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• Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
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• WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.
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• Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells.
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• Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.
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• Meis1-mediated apoptosis is caspase dependent and can be suppressed by coexpression of HoxA9 in murine and human cell lines.
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• Genomic maps and comparative analysis of histone modifications in human and mouse.
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• Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model.
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• Mouse brain organization revealed through direct genome-scale TF expression analysis.
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• From ORFeome to biology: a functional genomics pipeline.
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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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  Genome Res. 2004
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• Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells.
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  Mol Cell Biol. 2004
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• Protein kinase C-mediated phosphorylation of the leukemia-associated HOXA9 protein impairs its DNA binding ability and induces myeloid differentiation.
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  Mol Cell Biol. 2004
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• Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.
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  Blood. 2004
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• Expression of Hox cofactor genes during mouse ovarian follicular development and oocyte maturation.
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  Gene. 2004
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• Homeobox A9 transcriptionally regulates the EphB4 receptor to modulate endothelial cell migration and tube formation.
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• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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  Nature. 2004
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• Atlas of Hox gene expression in the developing kidney.
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  Dev Dyn. 2004
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• A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.
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• Expression of HOX genes in acute leukemia cell lines with and without MLL translocations.
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  Leuk Lymphoma. 2004
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• Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia.
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  Blood. 2004
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• The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells.
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• Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
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  Mol Cell Biol. 2004
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• GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
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  Nucleic Acids Res. 2004
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• B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOX A7 and HOX A9 expression.
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• Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia.
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  Leuk Lymphoma. 2003
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• Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior.
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  Genes Dev. 2003
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• The DNA sequence of human chromosome 7.
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  Nature. 2003
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• Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
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  Nature. 2003
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• A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23).
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• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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• Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.
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• The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9.
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• A case of acute myeloid leukemia with t(7;11)(p15;p15) mimicking myeloid crisis of chronic myelogenous leukemia.
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• Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1.
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• A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9.
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• Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).
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• DNA cloning using in vitro site-specific recombination.
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• Lumbosacral plexus in Hoxa9 knockout mice with special reference to their nerve variations identified according to whether they were interphenotypic or intergenotypic differences.
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• The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells.
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• Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm.
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• Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.
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• Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.
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