HOXA6
| Gene Description: |
homeobox A6 |
| Synonyms: |
HOX1.2, HOX1, HOXA6, Hox-1.2, HOX1B, Hoxa6 |
| Orthologs: |
Human HOXA6 (protein-coding), Mouse Hoxa6 (protein-coding), Rat Hoxa6 (protein-coding)
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Sources
Sources
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Human-Mouse:
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HomoloGene, MGD, RGD, Inparanoid
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Human-Rat:
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HomoloGene, MGD, RGD, Inparanoid
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Mouse-Rat:
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HomoloGene, MGD, RGD, Inparanoid
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Possible sources:
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HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG
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Regions of Interest Overlapping this feature from T1DBase
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Regions Overlapping this Feature:
Human: 1
Mouse: 1
Rat: 2
Associated Regions: Available
Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.
Other Regions: Available
Gene Overview from T1DBase
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Beta Cell Gene Atlas from T1DBase
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Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray
data generated with pancreatic beta cells and related cell lines and types. The
expression data comes from 131 array analyses derived from 28 experiments
(open details in a new window).
The basal (untreated cell) expression signal intensity values in each array
were converted to ranks within the experiments; the highest value was used for
genes represented by more than one probe. The rank values of genes in a given cell
type were averaged with other calculated values from experiments performed with the
same cell type. The rank transformation of the expression values enable comparison
of gene expression across different organisms and tissues.
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A red border around a cell indicates greater certainty in the data;
specifically, the gene has >0.95 probability of being expressed in the tissue.
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| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
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Expression Legend
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Signal intensity values were converted to ranks within the experiments.
For genes represented by more than one probeset, we averaged the intensity
signals for each probeset across all tissues and chose the probeset with the
highest average value. The rank transformation of the expression values enables
comparison of gene expression across different organisms and tissues.
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Interactions Table for HOXA6:
The HOXA6 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
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Cross-Reference to Pathways and GO Terms
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View all
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KEGG Network: None available
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Biocarta: None available
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Reactome: None available
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NCI-Nature Pathway Interaction Database: None available
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Gene Ontology: 6
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KEGG Network: None available
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NCI-Nature Pathway Interaction Database: None available
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Type 1 Diabetes Publications: 1
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Differences in expression of homeobox transcription factors in proximal and distal human small intestine.
Walters JR, Howard A, Rumble HE, Prathalingam SR, Shaw-Smith CJ, Legon S
Gastroenterology. 1997
PubMed ID: 9247466
Publications: 50
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
Jung H, Lacombe J, Mazzoni EO, Liem KF, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS
Neuron. 2010
PubMed ID: 20826310
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An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
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Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo.
Coulombe Y, Lemieux M, Moreau J, Aubin J, Joksimovic M, Bérubé-Simard FA, Tabariès S, Boucherat O, Guillou F, Larochelle C, Tuggle CK, Jeannotte L
PLoS One. 2010
PubMed ID: 20485555
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A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
Dev Cell. 2009
PubMed ID: 20059953
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Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity.
Voss AK, Collin C, Dixon MP, Thomas T
Dev Cell. 2009
PubMed ID: 19922872
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High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.
Mugford JW, Yu J, Kobayashi A, McMahon AP
Dev Biol. 2009
PubMed ID: 19591821
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A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
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Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal.
Dickson GJ, Kwasniewska A, Mills KI, Lappin TR, Thompson A
Exp Hematol. 2009
PubMed ID: 19157684
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Quantification of Hox and surfactant protein-B transcription during murine lung development.
Grier DG, Thompson A, Lappin TR, Halliday HL
Neonatology. 2009
PubMed ID: 19204410
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Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM
Cell. 2008
PubMed ID: 18662545
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GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
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Hox gene function in vertebrate gut morphogenesis: the case of the caecum.
Zacchetti G, Duboule D, Zakany J
Development. 2007
PubMed ID: 17942481
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Hox patterning of the vertebrate rib cage.
McIntyre DC, Rakshit S, Yallowitz AR, Loken L, Jeannotte L, Capecchi MR, Wellik DM
Development. 2007
PubMed ID: 17626057
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Critical role of the p400/mDomino chromatin-remodeling ATPase in embryonic hematopoiesis.
Ueda T, Watanabe-Fukunaga R, Ogawa H, Fukuyama H, Higashi Y, Nagata S, Fukunaga R
Genes Cells. 2007
PubMed ID: 17535249
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Comparative analysis of Hoxa5 allelic series.
Tabariès S, Lemieux M, Aubin J, Jeannotte L
Genesis. 2007
PubMed ID: 17417799
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hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
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A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
Development. 2006
PubMed ID: 16971476
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Genomic maps and comparative analysis of histone modifications in human and mouse.
Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ, Gingeras TR, Schreiber SL, Lander ES
Cell. 2005
PubMed ID: 15680324
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Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Atlas of Hox gene expression in the developing kidney.
Patterson LT, Potter SS
Dev Dyn. 2004
PubMed ID: 15042701
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The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
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Human chromosome 7: DNA sequence and biology.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
Science. 2003
PubMed ID: 12690205
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.
Wang J, Mager J, Schnedier E, Magnuson T
Mamm Genome. 2002
PubMed ID: 12370779
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Region-specific gastrointestinal Hox code during murine embryonal gut development.
Kawazoe Y, Sekimoto T, Araki M, Takagi K, Araki K, Yamamura K
Dev Growth Differ. 2002
PubMed ID: 11869294
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Complete mutation analysis panel of the 39 human HOX genes.
Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N
Teratology. 2002
PubMed ID: 11857506
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Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm.
Gaunt SJ, Dean W, Sang H, Burton RD
Mech Dev. 1999
PubMed ID: 10354475
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Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.
Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb MA, Nomura M, Tsuchiya R, Fujita Y, Shibata Y, Higashinakagawa T, Shimada K
Development. 1997
PubMed ID: 9367423
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Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.
Coré N, Bel S, Gaunt SJ, Aurrand-Lions M, Pearce J, Fisher A, Djabali M
Development. 1997
PubMed ID: 9043087
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Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6.
Innis JW, Darling SM, Kazen-Gillespie K, Post LC, Mortlock DP, Yang T
Mamm Genome. 1996
PubMed ID: 8833244
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Fine mapping of human HOX gene clusters.
Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B
Cytogenet Cell Genet. 1996
PubMed ID: 8646877
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A duplicated zone of polarizing activity in polydactylous mouse mutants.
Masuya H, Sagai T, Wakana S, Moriwaki K, Shiroishi T
Genes Dev. 1995
PubMed ID: 7628698
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Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Polyak K, Lee MH, Erdjument-Bromage H, Koff A, Roberts JM, Tempst P, Massagué J
Cell. 1994
PubMed ID: 8033212
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Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column.
Kostic D, Capecchi MR
Mech Dev. 1994
PubMed ID: 7918106
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Organization and expression of mouse Hox3 cluster genes.
Goto J, Miyabayashi T, Wakamatsu Y, Takahashi N, Muramatsu M
Mol Gen Genet. 1993
PubMed ID: 8099712
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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias.
Tkachuk DC, Kohler S, Cleary ML
Cell. 1992
PubMed ID: 1423624
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Vertebrate homeobox gene nomenclature.
Scott MP
Cell. 1992
PubMed ID: 1358459
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Hox-1.11 and Hox-4.9 homeobox genes.
Nazarali A, Kim Y, Nirenberg M
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1348361
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Identification of 10 murine homeobox genes.
Singh G, Kaur S, Stock JL, Jenkins NA, Gilbert DJ, Copeland NG, Potter SS
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1683707
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Nomenclature for human homeobox genes.
McAlpine PJ, Shows TB
Genomics. 1990
PubMed ID: 1973146
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Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network.
Gaunt SJ, Coletta PL, Pravtcheva D, Sharpe PT
Development. 1990
PubMed ID: 1976088
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Anterior boundaries of Hox gene expression in mesoderm-derived structures correlate with the linear gene order along the chromosome.
Dressler GR, Gruss P
Differentiation. 1989
PubMed ID: 2575552
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Organization of human class I homeobox genes.
Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A
Genome. 1989
PubMed ID: 2576652
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Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex.
Baron A, Featherstone MS, Hill RE, Hall A, Galliot B, Duboule D
EMBO J. 1987
PubMed ID: 2891503
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Region-specific expression of mouse homeobox genes in the embryonic mesoderm and central nervous system.
Toth LE, Slawin KL, Pintar JE, Nguyen-Huu MC
Proc Natl Acad Sci U S A. 1987
PubMed ID: 2889208
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Expression of a homeo domain protein in noncontact-inhibited cultured cells and postmitotic neurons.
Odenwald WF, Taylor CF, Palmer-Hill FJ, Friedrich V, Tani M, Lazzarini RA
Genes Dev. 1987
PubMed ID: 2890554
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Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7.
Bućan M, Yang-Feng T, Colberg-Poley AM, Wolgemuth DJ, Guenet JL, Francke U, Lehrach H
EMBO J. 1986
PubMed ID: 2878803
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Clustered homeo boxes are differentially expressed during murine development.
Colberg-Poley AM, Voss SD, Chowdhury K, Stewart CL, Wagner EF, Gruss P
Cell. 1985
PubMed ID: 2416462
Model Organism Phenotype Links
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This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.
External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network
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Relevant resources: