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HOXA2

Gene Description:   homeo box A2; homeobox A2 Synonyms:   Hoxa2, HOX1K, HOX1.11, MGC151482, HOXA2, Hox-1.11, MGC151484, Hoxa11, RATHOX111A, AI324701 Orthologs:   Human HOXA2 (protein-coding), Mouse Hoxa2 (protein-coding), Rat Hoxa2 (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Human-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 2

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
7p15.2	Human	chr7:26657962..27205282	0.55	75	rs7804356

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	829
Human 7p15.2 Orthologous Region	Mouse	chr6:51768205..52199869	0.43	14
Human 7p15.2 Orthologous Region	Rat	chr4:80112734..80552452	0.44	10

(Human) GRCh37 - chr7:27139721..27142430 (2.71 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr6:52112350..52115412 (36 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr4:80462651..80464927 (2.28 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HOXA2: The HOXA2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HOXA2   CHD4   BioGRID  empirical  20211142  HOXA2   ERCC8   BioGRID  empirical  20211142  HOXA2   ASB12   BioGRID  empirical  20211142  HOXA2   ZNF292   BioGRID  empirical  20211142  HOXA2   RAI14   BioGRID  empirical  20211142  HOXA2   CERS2   BioGRID  empirical  20211142  HOXA2   MEIS1   HPRD, IntAct  empirical  15617687  HOXA2   CIITA   BioGRID  empirical  20211142  HOXA2   ZDHHC6   BioGRID  empirical  20211142  HOXA2   BRCA1   BioGRID  empirical  20211142  HOXA2   TLE6   BioGRID  empirical  20211142  HOXA2   ZDHHC16   BioGRID  empirical  20211142  HOXA2   CSDA   BioGRID  empirical  20211142  HOXA2   RBM39   BioGRID  empirical  20211142

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 19   Negative regulation of transcription from RNA polymerase II promoter GO:0000122 Cell fate determination GO:0001709 Osteoblast development GO:0002076 Sequence-specific DNA binding transcription factor activity GO:0003700 Nucleus GO:0005634 Nucleolus GO:0005730 Segment specification GO:0007379 Motor axon guidance GO:0008045 Anterior/posterior pattern specification GO:0009952 Dorsal/ventral pattern formation GO:0009953 Rhombomere 2 development GO:0021568 Rhombomere 3 morphogenesis GO:0021658 Brain segmentation GO:0035284 Middle ear morphogenesis GO:0042474 Sequence-specific DNA binding GO:0043565 Negative regulation of neuron differentiation GO:0045665 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Embryonic viscerocranium morphogenesis GO:0048703 Embryonic skeletal system morphogenesis GO:0048704

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 19 Negative regulation of transcription from RNA polymerase II promoter GO:0000122 Cell fate determination GO:0001709 Osteoblast development GO:0002076 Sequence-specific DNA binding transcription factor activity GO:0003700 Nucleus GO:0005634 Nucleolus GO:0005730 Segment specification GO:0007379 Motor axon guidance GO:0008045 Anterior/posterior pattern specification GO:0009952 Dorsal/ventral pattern formation GO:0009953 Rhombomere 2 development GO:0021568 Rhombomere 3 morphogenesis GO:0021658 Brain segmentation GO:0035284 Middle ear morphogenesis GO:0042474 Sequence-specific DNA binding GO:0043565 Negative regulation of neuron differentiation GO:0045665 Positive regulation of transcription from RNA polymerase II promoter GO:0045944 Embryonic viscerocranium morphogenesis GO:0048703 Embryonic skeletal system morphogenesis GO:0048704

Type 1 Diabetes Publications: 1

• Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord.
  Hao Z, Yeung J, Wolf L, Doucette R, Nazarali A
  Dev Dyn. 1999
  PubMed ID: 10536059
   
  

Publications: 131

• Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.
  Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA
  Development. 2011
  PubMed ID: 21693512
   
  
• Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation.
  Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, Spetz JF, Selleri L, Rijli FM
  Dev Cell. 2011
  PubMed ID: 21497760
   
  
• Hoxb3 negatively regulates Hoxb1 expression in mouse hindbrain patterning.
  Wong EY, Wang XA, Mak SS, Sae-Pang JJ, Ling KW, Fritzsch B, Sham MH
  Dev Biol. 2011
  PubMed ID: 21320481
   
  
• A Runx2/miR-3960/miR-2861 regulatory feedback loop during mouse osteoblast differentiation.
  Hu R, Liu W, Li H, Yang L, Chen C, Xia ZY, Guo LJ, Xie H, Zhou HD, Wu XP, Luo XH
  J Biol Chem. 2011
  PubMed ID: 21324897
   
  
• Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.
  Kirilenko P, He G, Mankoo BS, Mallo M, Jones R, Bobola N
  Mol Cell Biol. 2011
  PubMed ID: 21245383
   
  
• HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.
  Kueh AJ, Dixon MP, Voss AK, Thomas T
  Mol Cell Biol. 2011
  PubMed ID: 21149574
   
  
• Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages.
  Shikata Y, Okada T, Hashimoto M, Ellis T, Matsumaru D, Shiroishi T, Ogawa M, Wainwright B, Motoyama J
  Dev Biol. 2011
  PubMed ID: 20969845
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
  Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL
  Gene Expr Patterns. 2011
  PubMed ID: 20932939
   
  
• Mesodermal Tbx1 is required for patterning the proximal mandible in mice.
  Aggarwal VS, Carpenter C, Freyer L, Liao J, Petti M, Morrow BE
  Dev Biol. 2010
  PubMed ID: 20501333
   
  
• Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue.
  Mao XY, Tang SJ
  Biochem Cell Biol. 2010
  PubMed ID: 20651846
   
  
• Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia.
  Monks DC, Jahangir A, Shanske AL, Samanich J, Morrow BE, Babcock M
  Int J Pediatr Otorhinolaryngol. 2010
  PubMed ID: 20542577
   
  
• A refined map of early gene expression in the dorsal rhombomere 1 of mouse embryos.
  Liu ZR, Shi M, Hu ZL, Zheng MH, Du F, Zhao G, Ding YQ
  Brain Res Bull. 2010
  PubMed ID: 20206242
   
  
• An atlas of combinatorial transcriptional regulation in mouse and man.
  Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
  Cell. 2010
  PubMed ID: 20211142
   
  
• Expressing Hoxa2 across the entire endochondral skeleton alters the shape of the skeletal template in a spatially restricted fashion.
  Tavella S, Bobola N
  Differentiation. 2010
  PubMed ID: 20034726
   
  
• Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-β3.
  Brown GD, Nazarali AJ
  BMC Dev Biol. 2010
  PubMed ID: 20809987
   
  
• A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
  Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H
  Dev Cell. 2009
  PubMed ID: 20059953
   
  
• Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.
  Ester AR, Weymouth KS, Burt A, Wise CA, Scott A, Gurnett CA, Dobbs MB, Blanton SH, Hecht JT
  Am J Med Genet A. 2009
  PubMed ID: 19938081
   
  
• Moz and retinoic acid coordinately regulate H3K9 acetylation, Hox gene expression, and segment identity.
  Voss AK, Collin C, Dixon MP, Thomas T
  Dev Cell. 2009
  PubMed ID: 19922872
   
  
• Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo.
  Yallowitz AR, Gong KQ, Swinehart IT, Nelson LT, Wellik DM
  Dev Biol. 2009
  PubMed ID: 19716816
   
  
• Hoxa2 plays a direct role in murine palate development.
  Smith TM, Wang X, Zhang W, Kulyk W, Nazarali AJ
  Dev Dyn. 2009
  PubMed ID: 19653318
   
  
• A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
  Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
  J Bone Miner Res. 2009
  PubMed ID: 19453261
   
  
• Rostral and caudal pharyngeal arches share a common neural crest ground pattern.
  Minoux M, Antonarakis GS, Kmita M, Duboule D, Rijli FM
  Development. 2009
  PubMed ID: 19168678
   
  
• Quantification of Hox and surfactant protein-B transcription during murine lung development.
  Grier DG, Thompson A, Lappin TR, Halliday HL
  Neonatology. 2009
  PubMed ID: 19204410
   
  
• Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.
  Gorivodsky M, Mukhopadhyay M, Wilsch-Braeuninger M, Phillips M, Teufel A, Kim C, Malik N, Huttner W, Westphal H
  Dev Biol. 2009
  PubMed ID: 18930042
   
  
• Identification and characterization of VPO1, a new animal heme-containing peroxidase.
  Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD
  Free Radic Biol Med. 2008
  PubMed ID: 18929642
   
  
• Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.
  Wassef MA, Chomette D, Pouilhe M, Stedman A, Havis E, Desmarquet-Trin Dinh C, Schneider-Maunoury S, Gilardi-Hebenstreit P, Charnay P, Ghislain J
  Development. 2008
  PubMed ID: 18787068
   
  
• Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling.
  Geisen MJ, Di Meglio T, Pasqualetti M, Ducret S, Brunet JF, Chedotal A, Rijli FM
  PLoS Biol. 2008
  PubMed ID: 18547144
   
  
• A mutation in HOXA2 is responsible for autosomal-recessive microtia in an Iranian family.
  Alasti F, Sadeghi A, Sanati MH, Farhadi M, Stollar E, Somers T, Van Camp G
  Am J Hum Genet. 2008
  PubMed ID: 18394579
   
  
• Six2 functions redundantly immediately downstream of Hoxa2.
  Kutejova E, Engist B, Self M, Oliver G, Kirilenko P, Bobola N
  Development. 2008
  PubMed ID: 18321982
   
  
• GUDMAP: the genitourinary developmental molecular anatomy project.
  McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
  J Am Soc Nephrol. 2008
  PubMed ID: 18287559
   
  
• Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development.
  Basson MA, Echevarria D, Ahn CP, Sudarov A, Joyner AL, Mason IJ, Martinez S, Martin GR
  Development. 2008
  PubMed ID: 18216176
   
  
• Toward a confocal subcellular atlas of the human proteome.
  Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
  Mol Cell Proteomics. 2008
  PubMed ID: 18029348
   
  
• Altered neuronal lineages in the facial ganglia of Hoxa2 mutant mice.
  Yang X, Zhou Y, Barcarse EA, O'Gorman S
  Dev Biol. 2008
  PubMed ID: 18164701
   
  
• SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis.
  Rizzoti K, Lovell-Badge R
  Development. 2007
  PubMed ID: 17728342
   
  
• Fate-mapping the mammalian hindbrain: segmental origins of vestibular projection neurons assessed using rhombomere-specific Hoxa2 enhancer elements in the mouse embryo.
  Pasqualetti M, Díaz C, Renaud JS, Rijli FM, Glover JC
  J Neurosci. 2007
  PubMed ID: 17804628
   
  
• Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.
  Matis C, Oury F, Remacle S, Lampe X, Gofflot F, Picard JJ, Rijli FM, Rezsohazy R
  Dev Dyn. 2007
  PubMed ID: 17676642
   
  
• Cranial neural crest cells regulate head muscle patterning and differentiation during vertebrate embryogenesis.
  Rinon A, Lazar S, Marshall H, Büchmann-Møller S, Neufeld A, Elhanany-Tamir H, Taketo MM, Sommer L, Krumlauf R, Tzahor E
  Development. 2007
  PubMed ID: 17652354
   
  
• Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.
  Coré N, Caubit X, Metchat A, Boned A, Djabali M, Fasano L
  Dev Biol. 2007
  PubMed ID: 17586487
   
  
• Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain.
  Saarimäki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J
  J Neurosci. 2007
  PubMed ID: 17687036
   
  
• Expression of Hoxa2 in cells entering chondrogenesis impairs overall cartilage development.
  Massip L, Ectors F, Deprez P, Maleki M, Behets C, Lengelé B, Delahaut P, Picard J, Rezsöhazy R
  Differentiation. 2007
  PubMed ID: 17359301
   
  
• Distinct roles of Hoxa2 and Krox20 in the development of rhythmic neural networks controlling inspiratory depth, respiratory frequency, and jaw opening.
  Chatonnet F, Wrobel LJ, Mézières V, Pasqualetti M, Ducret S, Taillebourg E, Charnay P, Rijli FM, Champagnat J
  Neural Develop. 2007
  PubMed ID: 17897445
   
  
• Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.
  Guo C, Qiu HY, Huang Y, Chen H, Yang RQ, Chen SD, Johnson RL, Chen ZF, Ding YQ
  Development. 2007
  PubMed ID: 17166916
   
  
• A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.
  Choi MY, Romer AI, Hu M, Lepourcelet M, Mechoor A, Yesilaltay A, Krieger M, Gray PA, Shivdasani RA
  Development. 2006
  PubMed ID: 16971476
   
  
• Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map.
  Oury F, Murakami Y, Renaud JS, Pasqualetti M, Charnay P, Ren SY, Rijli FM
  Science. 2006
  PubMed ID: 16902088
   
  
• SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.
  Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Fariñas I, Karsenty G, Grosschedl R
  Cell. 2006
  PubMed ID: 16751105
   
  
• A threshold requirement for Gbx2 levels in hindbrain development.
  Waters ST, Lewandoski M
  Development. 2006
  PubMed ID: 16651541
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Hox cofactors in vertebrate development.
  Moens CB, Selleri L
  Dev Biol. 2006
  PubMed ID: 16515781
   
  
• Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis.
  Santagati F, Minoux M, Ren SY, Rijli FM
  Development. 2005
  PubMed ID: 16221728
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Second branchial arch lineages of the middle ear of wild-type and Hoxa2 mutant mice.
  O'Gorman S
  Dev Dyn. 2005
  PubMed ID: 15861402
   
  
• Characteristic defects in neural crest cell-specific Galphaq/Galpha11- and Galpha12/Galpha13-deficient mice.
  Dettlaff-Swiercz DA, Wettschureck N, Moers A, Huber K, Offermanns S
  Dev Biol. 2005
  PubMed ID: 15936338
   
  
• New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.
  Li JY, Lao Z, Joyner AL
  Development. 2005
  PubMed ID: 15790971
   
  
• Fgfr1-dependent boundary cells between developing mid- and hindbrain.
  Trokovic R, Jukkola T, Saarimäki J, Peltopuro P, Naserke T, Weisenhorn DM, Trokovic N, Wurst W, Partanen J
  Dev Biol. 2005
  PubMed ID: 15680361
   
  
• Differential expression of Sonic hedgehog along the anterior-posterior axis regulates patterning of pharyngeal pouch endoderm and pharyngeal endoderm-derived organs.
  Moore-Scott BA, Manley NR
  Dev Biol. 2005
  PubMed ID: 15680353
   
  
• Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development.
  Moraes F, Nóvoa A, Jerome-Majewska LA, Papaioannou VE, Mallo M
  Mech Dev. 2005
  PubMed ID: 15652707
   
  
• Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.
  Kutejova E, Engist B, Mallo M, Kanzler B, Bobola N
  Development. 2005
  PubMed ID: 15634706
   
  
• Genomic maps and comparative analysis of histone modifications in human and mouse.
  Bernstein BE, Kamal M, Lindblad-Toh K, Bekiranov S, Bailey DK, Huebert DJ, McMahon S, Karlsson EK, Kulbokas EJ, Gingeras TR, Schreiber SL, Lander ES
  Cell. 2005
  PubMed ID: 15680324
   
  
• Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
  Williams TM, Williams ME, Innis JW
  Dev Biol. 2005
  PubMed ID: 15617687
   
  
• Mouse brain organization revealed through direct genome-scale TF expression analysis.
  Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
  Science. 2004
  PubMed ID: 15618518
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Early stages of oligodendrocyte development in the embryonic murine spinal cord proceed normally in the absence of Hoxa2.
  Nicolay DJ, Doucette JR, Nazarali AJ
  Glia. 2004
  PubMed ID: 15326611
   
  
• The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element.
  Lampe X, Picard JJ, Rezsohazy R
  Biochem Biophys Res Commun. 2004
  PubMed ID: 15033486
   
  
• Atlas of Hox gene expression in the developing kidney.
  Patterson LT, Potter SS
  Dev Dyn. 2004
  PubMed ID: 15042701
   
  
• Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects.
  Brewer S, Feng W, Huang J, Sullivan S, Williams T
  Dev Biol. 2004
  PubMed ID: 14975722
   
  
• Contribution of Hox genes to the diversity of the hindbrain sensory system.
  Gaufo GO, Wu S, Capecchi MR
  Development. 2004
  PubMed ID: 14960494
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
  Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• Zic2 is required for neural crest formation and hindbrain patterning during mouse development.
  Elms P, Siggers P, Napper D, Greenfield A, Arkell R
  Dev Biol. 2003
  PubMed ID: 14651926
   
  
• Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1.
  Bobola N, Carapuço M, Ohnemus S, Kanzler B, Leibbrandt A, Neubüser A, Drouin J, Mallo M
  Development. 2003
  PubMed ID: 12810588
   
  
• The DNA sequence of human chromosome 7.
  Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
  Nature. 2003
  PubMed ID: 12853948
   
  
• The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum.
  Chi CL, Martinez S, Wurst W, Martin GR
  Development. 2003
  PubMed ID: 12736208
   
  
• The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system.
  Niederreither K, Vermot J, Le Roux I, Schuhbaur B, Chambon P, Dollé P
  Development. 2003
  PubMed ID: 12702665
   
  
• Human chromosome 7: DNA sequence and biology.
  Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
  Science. 2003
  PubMed ID: 12690205
   
  
• Reversible gene inactivation in the mouse.
  Mallo M, Kanzler B, Ohnemus S
  Genomics. 2003
  PubMed ID: 12676559
   
  
• Fgfr1 regulates patterning of the pharyngeal region.
  Trokovic N, Trokovic R, Mai P, Partanen J
  Genes Dev. 2003
  PubMed ID: 12514106
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Tooth development is independent of a Hox patterning programme.
  James CT, Ohazama A, Tucker AS, Sharpe PT
  Dev Dyn. 2002
  PubMed ID: 12412017
   
  
• Targeted insertion results in a rhombomere 2-specific Hoxa2 knockdown and ectopic activation of Hoxa1 expression.
  Ren SY, Angrand PO, Rijli FM
  Dev Dyn. 2002
  PubMed ID: 12412013
   
  
• Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with Af9 after chromosomal translocation in leukemia.
  Collins EC, Appert A, Ariza-McNaughton L, Pannell R, Yamada Y, Rabbitts TH
  Mol Cell Biol. 2002
  PubMed ID: 12242306
   
  
• Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer.
  Li JY, Lao Z, Joyner AL
  Neuron. 2002
  PubMed ID: 12367504
   
  
• Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo.
  Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP
  Dev Biol. 2002
  PubMed ID: 12086465
   
  
• A Hoxa2 knockin allele that expresses EGFP upon conditional Cre-mediated recombination.
  Pasqualetti M, Ren SY, Poulet M, LeMeur M, Dierich A, Rijli FM
  Genesis. 2002
  PubMed ID: 11857792
   
  
• A Hoxa2 mutant conditional allele generated by Flp- and Cre-mediated recombination.
  Ren SY, Pasqualetti M, Dierich A, Le Meur M, Rijli FM
  Genesis. 2002
  PubMed ID: 11857791
   
  
• Complete mutation analysis panel of the 39 human HOX genes.
  Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N
  Teratology. 2002
  PubMed ID: 11857506
   
  
• Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression.
  Li JY, Joyner AL
  Development. 2001
  PubMed ID: 11748135
   
  
• Different levels of Hoxa2 are required for particular developmental processes.
  Ohnemus S, Bobola N, Kanzler B, Mallo M
  Mech Dev. 2001
  PubMed ID: 11578867
   
  
• Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.
  Gavalas A, Trainor P, Ariza-McNaughton L, Krumlauf R
  Development. 2001
  PubMed ID: 11532923
   
  
• Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon.
  Wolf LV, Yeung JM, Doucette JR, Nazarali AJ
  Neuroreport. 2001
  PubMed ID: 11209945
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
  Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
  Genome Res. 2000
  PubMed ID: 11042159
   
  
• Temporal and spatial expression of Hoxa-2 during murine palatogenesis.
  Nazarali A, Puthucode R, Leung V, Wolf L, Hao Z, Yeung J
  Cell Mol Neurobiol. 2000
  PubMed ID: 10789828
   
  
• Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.
  Barrow JR, Stadler HS, Capecchi MR
  Development. 2000
  PubMed ID: 10662633
   
  
• Retinoic acid synthesis and hindbrain patterning in the mouse embryo.
  Niederreither K, Vermot J, Schuhbaur B, Chambon P, Dollé P
  Development. 2000
  PubMed ID: 10654602
   
  
• Signaling pathways crucial for craniofacial development revealed by endothelin-A receptor-deficient mice.
  Clouthier DE, Williams SC, Yanagisawa H, Wieduwilt M, Richardson JA, Yanagisawa M
  Dev Biol. 2000
  PubMed ID: 10625532
   
  
• Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants.
  Barrow JR, Capecchi MR
  Development. 1999
  PubMed ID: 10529419
   
  
• Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain.
  Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM
  Neuron. 1999
  PubMed ID: 10230789
   
  
• Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family.
  Maconochie M, Krishnamurthy R, Nonchev S, Meier P, Manzanares M, Mitchell PJ, Krumlauf R
  Development. 1999
  PubMed ID: 10068641
   
  
• High-efficiency full-length cDNA cloning.
  Carninci P, Hayashizaki Y
  Methods Enzymol. 1999
  PubMed ID: 10349636
   
  
• Hoxa1 and Krox-20 synergize to control the development of rhombomere 3.
  Helmbacher F, Pujades C, Desmarquet C, Frain M, Rijli FM, Chambon P, Charnay P
  Development. 1998
  PubMed ID: 9806922
   
  
• Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area.
  Kanzler B, Kuschert SJ, Liu YH, Mallo M
  Development. 1998
  PubMed ID: 9636074
   
  
• Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.
  Rhinn M, Dierich A, Shawlot W, Behringer RR, Le Meur M, Ang SL
  Development. 1998
  PubMed ID: 9449667
   
  
• Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning.
  Gavalas A, Davenne M, Lumsden A, Chambon P, Rijli FM
  Development. 1997
  PubMed ID: 9367425
   
  
• Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.
  Takihara Y, Tomotsune D, Shirai M, Katoh-Fukui Y, Nishii K, Motaleb MA, Nomura M, Tsuchiya R, Fujita Y, Shibata Y, Higashinakagawa T, Shimada K
  Development. 1997
  PubMed ID: 9367423
   
  
• Segmental identity can change independently in the hindbrain and rhombencephalic neural crest.
  Mallo M, Brändlin I
  Dev Dyn. 1997
  PubMed ID: 9337135
   
  
• Retinoic acid disturbs mouse middle ear development in a stage-dependent fashion.
  Mallo M
  Dev Biol. 1997
  PubMed ID: 9142993
   
  
• In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE).
  Dupé V, Davenne M, Brocard J, Dollé P, Mark M, Dierich A, Chambon P, Rijli FM
  Development. 1997
  PubMed ID: 9053316
   
  
• Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve.
  Goddard JM, Rossel M, Manley NR, Capecchi MR
  Development. 1996
  PubMed ID: 8898234
   
  
• The expression pattern of the mouse receptor tyrosine kinase gene MDK1 is conserved through evolution and requires Hoxa-2 for rhombomere-specific expression in mouse embryos.
  Taneja R, Thisse B, Rijli FM, Thisse C, Bouillet P, Dollé P, Chambon P
  Dev Biol. 1996
  PubMed ID: 8806819
   
  
• Orientation of the Hoxa complex and placement of the Hd locus distal to Hoxa2 on mouse chromosome 6.
  Innis JW, Darling SM, Kazen-Gillespie K, Post LC, Mortlock DP, Yang T
  Mamm Genome. 1996
  PubMed ID: 8833244
   
  
• Segmental expression of Hoxa-2 in the hindbrain is directly regulated by Krox-20.
  Nonchev S, Vesque C, Maconochie M, Seitanidou T, Ariza-McNaughton L, Frain M, Marshall H, Sham MH, Krumlauf R, Charnay P
  Development. 1996
  PubMed ID: 8625806
   
  
• Fine mapping of human HOX gene clusters.
  Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B
  Cytogenet Cell Genet. 1996
  PubMed ID: 8646877
   
  
• Development of the mammalian ear: coordinate regulation of formation of the tympanic ring and the external acoustic meatus.
  Mallo M, Gridley T
  Development. 1996
  PubMed ID: 8565828
   
  
• The role of Hoxa-3 in mouse thymus and thyroid development.
  Manley NR, Capecchi MR
  Development. 1995
  PubMed ID: 7635047
   
  
• Evolutionary-conserved enhancers direct region-specific expression of the murine Hoxa-1 and Hoxa-2 loci in both mice and Drosophila.
  Frasch M, Chen X, Lufkin T
  Development. 1995
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