FOXA2

Summary Top Help

Gene Description:

forkhead box A2

Synonyms:

HNF3B, FOXA2, HNF3beta, Foxa2, TCF3B, Hnf3b, HNF3-beta, Tcf3b, Hnf-3b, Tcf-3b

Orthologs:

Human FOXA2 (protein-coding), Mouse Foxa2 (protein-coding), Rat Foxa2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1 Rat: 2

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd13	Mouse	chr2:114118625..158330390	44.21	582	3 no lod score

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm27	Rat	chr3:96506745..149496698	52.99	606
Iddm13	Rat	chr3:131188558..163778754	32.59	406

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr20:22561642..22566101 (4.46 kb) View in Genome Browser

(Mouse) NCBIM37 - chr2:147868613..147872705 (49 kb) View in Genome Browser

(Rat) RGSC3.4 - chr3:136739009..136743204 (4.20 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for FOXA2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for FOXA2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 4

Gene Ontology: 55

Positive regulation of transcription from RNA polymerase II promoter by glucose	GO:0000432
Negative regulation of transcription from RNA polymerase II promoter by glucose	GO:0000433
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978
In utero embryonic development	GO:0001701
Ectoderm formation	GO:0001705
DNA binding	GO:0003677
Double-stranded DNA binding	GO:0003690
Sequence-specific DNA binding transcription factor activity	GO:0003700
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	GO:0003705
Nucleus	GO:0005634
Transcription factor complex	GO:0005667
Cytoplasm	GO:0005737
Regulation of transcription from RNA polymerase II promoter	GO:0006357
Pattern specification process	GO:0007389
Endoderm development	GO:0007492
Transcription factor binding	GO:0008134
DNA binding, bending	GO:0008301
Anterior/posterior pattern specification	GO:0009952
Negative regulation of epithelial to mesenchymal transition	GO:0010719
Chromatin modification	GO:0016568
Protein domain specific binding	GO:0019904
Cell differentiation in hindbrain	GO:0021533
Oligodendrocyte cell fate commitment	GO:0021779
Dorsal/ventral neural tube patterning	GO:0021904
Signal transduction involved in regulation of gene expression	GO:0023019
Regulation of blood coagulation	GO:0030193
Lung development	GO:0030324
Endocrine pancreas development	GO:0031018
Central nervous system myelin formation	GO:0032289
Somite rostral/caudal axis specification	GO:0032525
Response to insulin stimulus	GO:0032868
Negative regulation of glucokinase activity	GO:0033132
Positive regulation of embryonic development	GO:0040019
Negative regulation of sequence-specific DNA binding transcription factor activity	GO:0043433
Sequence-specific DNA binding	GO:0043565
Transcription regulatory region DNA binding	GO:0044212
Cell part	GO:0044464
Negative regulation of neuron differentiation	GO:0045665
Positive regulation of neuron differentiation	GO:0045666
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of transcription from RNA polymerase III promoter	GO:0045945
SMAD binding	GO:0046332
Cell development	GO:0048468
Neuron fate specification	GO:0048665
Regulation of sequence-specific DNA binding transcription factor activity	GO:0051090
Epithelial tube branching involved in lung morphogenesis	GO:0060441
Lung epithelial cell differentiation	GO:0060487
Regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178
Response to interleukin-6	GO:0070741
Primitive streak formation	GO:0090009
Positive regulation of cell-cell adhesion mediated by cadherin	GO:2000049
Positive regulation of gastrulation	GO:2000543
Negative regulation of detection of glucose	GO:2000971
Regulation of transcription from RNA polymerase II promoter involved in detection of glucose	GO:2000976

KEGG Network: 1
Maturity onset diabetes of the young	Human - 4950	Mouse - 4950	Rat - 4950

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 4

FOXA2 and FOXA3 transcription factor networks

Hedgehog signaling events mediated by Gli proteins

FOXA1 transcription factor network

FOXA transcription factor networks

Gene Ontology: 55
Positive regulation of transcription from RNA polymerase II promoter by glucose	GO:0000432
Negative regulation of transcription from RNA polymerase II promoter by glucose	GO:0000433
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978
In utero embryonic development	GO:0001701
Ectoderm formation	GO:0001705
DNA binding	GO:0003677
Double-stranded DNA binding	GO:0003690
Sequence-specific DNA binding transcription factor activity	GO:0003700
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	GO:0003705
Nucleus	GO:0005634
Transcription factor complex	GO:0005667
Cytoplasm	GO:0005737
Regulation of transcription from RNA polymerase II promoter	GO:0006357
Pattern specification process	GO:0007389
Endoderm development	GO:0007492
Transcription factor binding	GO:0008134
DNA binding, bending	GO:0008301
Anterior/posterior pattern specification	GO:0009952
Negative regulation of epithelial to mesenchymal transition	GO:0010719
Chromatin modification	GO:0016568
Protein domain specific binding	GO:0019904
Cell differentiation in hindbrain	GO:0021533
Oligodendrocyte cell fate commitment	GO:0021779
Dorsal/ventral neural tube patterning	GO:0021904
Signal transduction involved in regulation of gene expression	GO:0023019
Regulation of blood coagulation	GO:0030193
Lung development	GO:0030324
Endocrine pancreas development	GO:0031018
Central nervous system myelin formation	GO:0032289
Somite rostral/caudal axis specification	GO:0032525
Response to insulin stimulus	GO:0032868
Negative regulation of glucokinase activity	GO:0033132
Positive regulation of embryonic development	GO:0040019
Negative regulation of sequence-specific DNA binding transcription factor activity	GO:0043433
Sequence-specific DNA binding	GO:0043565
Transcription regulatory region DNA binding	GO:0044212
Cell part	GO:0044464
Negative regulation of neuron differentiation	GO:0045665
Positive regulation of neuron differentiation	GO:0045666
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of transcription from RNA polymerase III promoter	GO:0045945
SMAD binding	GO:0046332
Cell development	GO:0048468
Neuron fate specification	GO:0048665
Regulation of sequence-specific DNA binding transcription factor activity	GO:0051090
Epithelial tube branching involved in lung morphogenesis	GO:0060441
Lung epithelial cell differentiation	GO:0060487
Regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0061178
Response to interleukin-6	GO:0070741
Primitive streak formation	GO:0090009
Positive regulation of cell-cell adhesion mediated by cadherin	GO:2000049
Positive regulation of gastrulation	GO:2000543
Negative regulation of detection of glucose	GO:2000971
Regulation of transcription from RNA polymerase II promoter involved in detection of glucose	GO:2000976

Publications from PubMed Top Help

Type 1 Diabetes Publications: 42

The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice.
Yang Y, Chang BH, Yechoor V, Chen W, Li L, Tsai MJ, Chan L
Diabetologia. 2011
PubMed ID: 21786021
Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic β-cells dysfunction.
Chen F, Zhu Y, Tang X, Sun Y, Jia W, Sun Y, Han X
Endocrinology. 2011
PubMed ID: 21385937
Sox9-haploinsufficiency causes glucose intolerance in mice.
Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M
PLoS One. 2011
PubMed ID: 21829703
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.
Hoffman BG, Robertson G, Zavaglia B, Beach M, Cullum R, Lee S, Soukhatcheva G, Li L, Wederell ED, Thiessen N, Bilenky M, Cezard T, Tam A, Kamoh B, Birol I, Dai D, Zhao Y, Hirst M, Verchere CB, Helgason CD, Marra MA, Jones SJ, Hoodless PA
Genome Res. 2010
PubMed ID: 20551221
Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.
Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH
Mol Endocrinol. 2010
PubMed ID: 20534694
Rfx6 directs islet formation and insulin production in mice and humans.
Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Eijnden SV, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS
Nature. 2010
PubMed ID: 20148032
Foxa1 and Foxa2 control the differentiation of goblet and enteroendocrine L- and D-cells in mice.
Ye DZ, Kaestner KH
Gastroenterology. 2009
PubMed ID: 19737569
Islet-1 is required for the maturation, proliferation and survival of the endocrine pancreas.
Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL
Diabetes. 2009
PubMed ID: 19502415
The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA
J Clin Invest. 2009
PubMed ID: 19487809
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH
Genes Dev. 2008
PubMed ID: 19141476
Genetic variants of FOXA2: risk of type 2 diabetes and effect on metabolic traits in North Indians.
Tabassum R, Chavali S, Dwivedi OP, Tandon N, Bharadwaj D
J Hum Genet. 2008
PubMed ID: 18797817
Foxa2 and MafA RegulateIslet-specific Glucose-6-Phosphatase Catalytic Subunit-Related Protein (IGRP/G6PC2)Gene Expression.
Martin C, Flemming B, Wang Y, Oeser J, O'Brien R
J Mol Endocrinol. 2008
PubMed ID: 18753309
Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones S, Marra MA, Helgason CD
Genome Biol. 2008
PubMed ID: 18554416
Expression of Groucho/TLE proteins during pancreas development.
Hoffman BG, Zavaglia B, Beach M, Helgason CD
BMC Dev Biol. 2008
PubMed ID: 18778483
MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3.
Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA
Dev Biol. 2007
PubMed ID: 17936263
Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.
Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH
Cell Metab. 2007
PubMed ID: 17908556
Transcriptional regulation of the distal promoter of the rat pyruvate carboxylase gene by hepatocyte nuclear factor 3beta/Foxa2 and upstream stimulatory factors in insulinoma cells.
Boonsaen T, Rojvirat P, Surinya KH, Wallace JC, Jitrapakdee S
Biochem J. 2007
PubMed ID: 17408383
PED/PEA-15 regulates glucose-induced insulin secretion by restraining potassium channel expression in pancreatic beta-cells.
Miele C, Raciti GA, Cassese A, Romano C, Giacco F, Oriente F, Paturzo F, Andreozzi F, Zabatta A, Troncone G, Bosch F, Pujol A, Chneiweiss H, Formisano P, Beguinot F
Diabetes. 2007
PubMed ID: 17327429
Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.
Svensson P, Williams C, Lundeberg J, Rydén P, Bergqvist I, Edlund H
BMC Dev Biol. 2007
PubMed ID: 18036209
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site.
Raum JC, Gerrish K, Artner I, Henderson E, Guo M, Sussel L, Schisler JC, Newgard CB, Stein R
Mol Cell Biol. 2006
PubMed ID: 16847327
The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.
Ritz-Laser B, Mamin A, Brun T, Avril I, Schwitzgebel VM, Philippe J
Mol Endocrinol. 2005
PubMed ID: 15539431
Foxa2 is required for the differentiation of pancreatic alpha-cells.
Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH
Dev Biol. 2005
PubMed ID: 15680365
Foxa2 regulates multiple pathways of insulin secretion.
Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH
J Clin Invest. 2004
PubMed ID: 15314688
Conserved transcriptional regulatory domains of the pdx-1 gene.
Gerrish K, Van Velkinburgh JC, Stein R
Mol Endocrinol. 2004
PubMed ID: 14701942
Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
Suzuki R, Tobe K, Terauchi Y, Komeda K, Kubota N, Eto K, Yamauchi T, Azuma K, Kaneto H, Taguchi T, Koga T, German MS, Watada H, Kawamori R, Wright CV, Kajimoto Y, Kimura S, Nagai R, Kadowaki T
J Biol Chem. 2003
PubMed ID: 12869553
Role of Foxa-2 in adipocyte metabolism and differentiation.
Wolfrum C, Shih DQ, Kuwajima S, Norris AW, Kahn CR, Stoffel M
J Clin Invest. 2003
PubMed ID: 12865419
The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.
Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH, Wright CV, White MF, Arden KC, Accili D
J Clin Invest. 2002
PubMed ID: 12488434
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors.
Zhou J, Pineyro MA, Wang X, Doyle ME, Egan JM
J Cell Physiol. 2002
PubMed ID: 12124776
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo.
Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH
Diabetes. 2002
PubMed ID: 12145169
Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release.
Wang H, Gauthier BR, Hagenfeldt-Johansson KA, Iezzi M, Wollheim CB
J Biol Chem. 2002
PubMed ID: 11875061
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.
Shih DQ, Heimesaat M, Kuwajima S, Stein R, Wright CV, Stoffel M
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11904435
Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia.
Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH
Genes Dev. 2001
PubMed ID: 11445544
Identification of missense mutations in the hepatocyte nuclear factor-3beta gene in Japanese subjects with late-onset Type II diabetes mellitus.
Zhu Q, Yamagata K, Yu L, Tomura H, Yamada S, Yang Q, Yoshiuchi I, Sumi S, Miyagawa J, Takeda J, Hanafusa T, Matsuzawa Y
Diabetologia. 2000
PubMed ID: 11043867
Genetic variation in the hepatocyte nuclear factor-3beta gene (HNF3B) does not contribute to maturity-onset diabetes of the young in French Caucasians.
Abderrahmani A, Chèvre JC, Otabe S, Chikri M, Hani EH, Vaxillaire M, Hinokio Y, Horikawa Y, Bell GI, Froguel P
Diabetes. 2000
PubMed ID: 10868949
Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young.
Hinokio Y, Horikawa Y, Furuta H, Cox NJ, Iwasaki N, Honda M, Ogata M, Iwamoto Y, Bell GI
Diabetes. 2000
PubMed ID: 10868948
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.
Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH
Nat Genet. 1999
PubMed ID: 10471502
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
Kaestner KH, Katz J, Liu Y, Drucker DJ, Schütz G
Genes Dev. 1999
PubMed ID: 10049364
In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos.
Rausa FM, Ye H, Lim L, Duncan SA, Costa RH
Methods. 1998
PubMed ID: 9774514
The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas.
Rausa F, Samadani U, Ye H, Lim L, Fletcher CF, Jenkins NA, Copeland NG, Costa RH
Dev Biol. 1997
PubMed ID: 9441664
Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene.
Wu KL, Gannon M, Peshavaria M, Offield MF, Henderson E, Ray M, Marks A, Gamer LW, Wright CV, Stein R
Mol Cell Biol. 1997
PubMed ID: 9315659
The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.
Ahlgren U, Jonsson J, Edlund H
Development. 1996
PubMed ID: 8625829
Hepatocyte-nuclear factor 3 beta gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene.
Philippe J
Mol Endocrinol. 1995
PubMed ID: 7776982

Publications: 546

Clonal and molecular analysis of the prospective anterior neural boundary in the mouse embryo.
Cajal M, Lawson KA, Hill B, Moreau A, Rao J, Ross A, Collignon J, Camus A
Development. 2012
PubMed ID: 22186731
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, Peterson AS
Nat Cell Biol. 2012
PubMed ID: 22179047
Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis.
Li P, Pashmforoush M, Sucov HM
Dev Biol. 2012
PubMed ID: 22040871
Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression.
Madabhushi M, Lacy E
Dev Cell. 2011
PubMed ID: 22075149
Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning.
Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, De Luca P, de Carvalho DP, Ceccarelli M, De Felice M, Di Lauro R
Dev Biol. 2011
PubMed ID: 21924257
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c.
Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ
Cell Metab. 2011
PubMed ID: 21982711
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
Kishimoto K, Nishizuka M, Ueda T, Kajita K, Ugawa S, Shimada S, Osada S, Imagawa M
Exp Cell Res. 2011
PubMed ID: 21704616
Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo.
Stottmann RW, Turbe-Doan A, Tran P, Kratz LE, Moran JL, Kelley RI, Beier DR
PLoS Genet. 2011
PubMed ID: 21912524
The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities.
Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB
Genes Dev. 2011
PubMed ID: 21896659
Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry.
Komatsu Y, Kaartinen V, Mishina Y
Development. 2011
PubMed ID: 21831921
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.
Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ
Nat Cell Biol. 2011
PubMed ID: 21822279
Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.
Wang H, Lei Q, Oosterveen T, Ericson J, Matise MP
Development. 2011
PubMed ID: 21775418
Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.
Tsao PN, Wei SC, Wu MF, Huang MT, Lin HY, Lee MC, Lin KM, Wang IJ, Kaartinen V, Yang LT, Cardoso WV
Development. 2011
PubMed ID: 21791528
PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube.
Heydeck W, Liu A
Dev Dyn. 2011
PubMed ID: 21761479
Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development.
Deng Q, Andersson E, Hedlund E, Alekseenko Z, Coppola E, Panman L, Millonig JH, Brunet JF, Ericson J, Perlmann T
Development. 2011
PubMed ID: 21752929
Disruption of a ciliary B9 protein complex causes Meckel syndrome.
Dowdle WE, Robinson JF, Kneist A, Sirerol-Piquer MS, Frints SG, Corbit KC, Zaghloul NA, van Lijnschoten G, Mulders L, Verver DE, Zerres K, Reed RR, Attié-Bitach T, Johnson CA, García-Verdugo JM, Katsanis N, Bergmann C, Reiter JF
Am J Hum Genet. 2011
PubMed ID: 21763481
Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.
Migeotte I, Grego-Bessa J, Anderson KV
Development. 2011
PubMed ID: 21693517
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
Essential roles of fibronectin in the development of the left-right embryonic body plan.
Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S
Dev Biol. 2011
PubMed ID: 21466802
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function.
Allen BL, Song JY, Izzi L, Althaus IW, Kang JS, Charron F, Krauss RS, McMahon AP
Dev Cell. 2011
PubMed ID: 21664576
Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.
Nefzger CM, Haynes JM, Pouton CW
Stem Cells. 2011
PubMed ID: 21472823
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Sang L, Miller JJ, Corbit KC, Giles RH, Brauer MJ, Otto EA, Baye LM, Wen X, Scales SJ, Kwong M, Huntzicker EG, Sfakianos MK, Sandoval W, Bazan JF, Kulkarni P, Garcia-Gonzalo FR, Seol AD, O'Toole JF, Held S, Reutter HM, Lane WS, Rafiq MA, Noor A, Ansar M, Devi AR, Sheffield VC, Slusarski DC, Vincent JB, Doherty DA, Hildebrandt F, Reiter JF, Jackson PK
Cell. 2011
PubMed ID: 21565611
Epigenetic regulation of the transcription factor Foxa2 directs differential elafin expression in melanocytes and melanoma cells.
Yu KS, Jo JY, Kim SJ, Lee Y, Bae JH, Chung YH, Koh SS
Biochem Biophys Res Commun. 2011
PubMed ID: 21466784
Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.
Li J, Wang C, Pan Y, Bai Z, Wang B
Dev Dyn. 2011
PubMed ID: 21337666
Species-specific strategies underlying conserved functions of metabolic transcription factors.
Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH
Mol Endocrinol. 2011
PubMed ID: 21292830
GABAergic and glutamatergic identities of developing midbrain Pitx2 neurons.
Waite MR, Skidmore JM, Billi AC, Martin JF, Martin DM
Dev Dyn. 2011
PubMed ID: 21246650
Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity.
Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ
Development. 2011
PubMed ID: 21205797
FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers.
Tang Y, Shu G, Yuan X, Jing N, Song J
Cell Res. 2011
PubMed ID: 20820189
Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.
Qin J, Lin Y, Norman RX, Ko HW, Eggenschwiler JT
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21209331
Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome.
Pei L, Leblanc M, Barish G, Atkins A, Nofsinger R, Whyte J, Gold D, He M, Kawamura K, Li HR, Downes M, Yu RT, Powell HC, Lingrel JB, Evans RM
Nat Med. 2011
PubMed ID: 22001906
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei.
Blaess S, Bodea GO, Kabanova A, Chanet S, Mugniery E, Derouiche A, Stephen D, Joyner AL
Neural Dev. 2011
PubMed ID: 21689430
Immunohistochemical detection and regulation of α5 nicotinic acetylcholine receptor (nAChR) subunits by FoxA2 during mouse lung organogenesis.
Porter JL, Bukey BR, Geyer AJ, Willnauer CP, Reynolds PR
Respir Res. 2011
PubMed ID: 21682884
Correct patterning of the primitive streak requires the anterior visceral endoderm.
Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA
PLoS One. 2011
PubMed ID: 21445260
[Molecular mechanism of interleukin-13-induced mucus hypersecretion in rat airway].
Jiang DP, Kolosov VP, Perelman JM, Zhou XD
Nan Fang Yi Ke Da Xue Xue Bao. 2011
PubMed ID: 21269961
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Foxa1 and Foxa2 positively and negatively regulate Shh signalling to specify ventral midbrain progenitor identity.
Mavromatakis YE, Lin W, Metzakopian E, Ferri AL, Yan CH, Sasaki H, Whisett J, Ang SL
Mech Dev. 2011
PubMed ID: 21093585
Disruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndrome.
Cui C, Chatterjee B, Francis D, Yu Q, SanAgustin JT, Francis R, Tansey T, Henry C, Wang B, Lemley B, Pazour GJ, Lo CW
Dis Model Mech. 2011
PubMed ID: 21045211
Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.
Sylvestersen KB, Herrera PL, Serup P, Rescan C
Gene Expr Patterns. 2011
PubMed ID: 20934536
Foxa2 regulates the expression of Nato3 in the floor plate by a novel evolutionarily conserved promoter.
Mansour AA, Nissim-Eliraz E, Zisman S, Golan-Lev T, Schatz O, Klar A, Ben-Arie N
Mol Cell Neurosci. 2011
PubMed ID: 20849957
Foxj1 regulates floor plate cilia architecture and modifies the response of cells to sonic hedgehog signalling.
Cruz C, Ribes V, Kutejova E, Cayuso J, Lawson V, Norris D, Stevens J, Davey M, Blight K, Bangs F, Mynett A, Hirst E, Chung R, Balaskas N, Brody SL, Marti E, Briscoe J
Development. 2010
PubMed ID: 21098568
The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance.
Holz A, Kollmus H, Ryge J, Niederkofler V, Dias J, Ericson J, Stoeckli ET, Kiehn O, Arnold HH
Development. 2010
PubMed ID: 21068056
A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.
Lek M, Dias JM, Marklund U, Uhde CW, Kurdija S, Lei Q, Sussel L, Rubenstein JL, Matise MP, Arnold HH, Jessell TM, Ericson J
Development. 2010
PubMed ID: 21062862
Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP.
Di Salvio M, Di Giovannantonio LG, Acampora D, Prosperi R, Omodei D, Prakash N, Wurst W, Simeone A
Nat Neurosci. 2010
PubMed ID: 21057506
Lack of motor neuron differentiation is an intrinsic property of the mouse secondary neural tube.
Shum AS, Tang LS, Copp AJ, Roelink H
Dev Dyn. 2010
PubMed ID: 20960561
Wnt/planar cell polarity signaling controls the anterior-posterior organization of monoaminergic axons in the brainstem.
Fenstermaker AG, Prasad AA, Bechara A, Adolfs Y, Tissir F, Goffinet A, Zou Y, Pasterkamp RJ
J Neurosci. 2010
PubMed ID: 21106844
FoxOs function synergistically to promote glucose production.
Haeusler RA, Kaestner KH, Accili D
J Biol Chem. 2010
PubMed ID: 20880840
The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.
Werth M, Walentin K, Aue A, Schönheit J, Wuebken A, Pode-Shakked N, Vilianovitch L, Erdmann B, Dekel B, Bader M, Barasch J, Rosenbauer F, Luft FC, Schmidt-Ott KM
Development. 2010
PubMed ID: 20978075
Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.
Yu S, Poe B, Schwarz M, Elliot SA, Albertine KH, Fenton S, Garg V, Moon AM
Dev Biol. 2010
PubMed ID: 20727874
Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer.
Rojas A, Schachterle W, Xu SM, Martín F, Black BL
Dev Biol. 2010
PubMed ID: 20692247
Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline.
Lee JD, Migeotte I, Anderson KV
Dev Biol. 2010
PubMed ID: 20678497
Liver-enriched transcription factors regulate microRNA-122 that targets CUTL1 during liver development.
Xu H, He JH, Xiao ZD, Zhang QQ, Chen YQ, Zhou H, Qu LH
Hepatology. 2010
PubMed ID: 20842632
O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.
Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC
Dev Biol. 2010
PubMed ID: 20637190
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
The Siah2-HIF-FoxA2 axis in prostate cancer – new markers and therapeutic opportunities.
Qi J, Pellecchia M, Ronai ZA
Oncotarget. 2010
PubMed ID: 21037926
Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain.
Leung AW, Wong SY, Chan D, Tam PP, Cheah KS
Dev Dyn. 2010
PubMed ID: 20730911
Foxa2 is essential for mouse endometrial gland development and fertility.
Jeong JW, Kwak I, Lee KY, Kim TH, Large MJ, Stewart CL, Kaestner KH, Lydon JP, DeMayo FJ
Biol Reprod. 2010
PubMed ID: 20484741
An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo.
Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA
Dev Cell. 2010
PubMed ID: 20708584
Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.
Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S
Development. 2010
PubMed ID: 20573697
BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning.
Yang YP, Anderson RM, Klingensmith J
Hum Mol Genet. 2010
PubMed ID: 20508035
Development of head organizer of the mouse embryo depends on a high level of mitochondrial metabolism.
Zhou X, Anderson KV
Dev Biol. 2010
PubMed ID: 20450902
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning.
Song H, Hu J, Chen W, Elliott G, Andre P, Gao B, Yang Y
Nature. 2010
PubMed ID: 20562861
Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors.
Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA
Cancer Cell. 2010
PubMed ID: 20609350
Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons.
Tang M, Villaescusa JC, Luo SX, Guitarte C, Lei S, Miyamoto Y, Taketo MM, Arenas E, Huang EJ
J Neurosci. 2010
PubMed ID: 20610763
Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse.
Vaziri Sani F, Kaartinen V, El Shahawy M, Linde A, Gritli-Linde A
Eur J Oral Sci. 2010
PubMed ID: 20572855
Ectoderm, endoderm, and the evolution of heterodont dentitions.
Ohazama A, Haworth KE, Ota MS, Khonsari RH, Sharpe PT
Genesis. 2010
PubMed ID: 20533405
Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube.
Ribes V, Balaskas N, Sasai N, Cruz C, Dessaud E, Cayuso J, Tozer S, Yang LL, Novitch B, Marti E, Briscoe J
Genes Dev. 2010
PubMed ID: 20516201
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA
J Immunol. 2010
PubMed ID: 20483781
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
Wang C, Pan Y, Wang B
Development. 2010
PubMed ID: 20463034
The basic helix-loop-helix transcription factor Nato3 controls neurogenic activity in mesencephalic floor plate cells.
Ono Y, Nakatani T, Minaki Y, Kumai M
Development. 2010
PubMed ID: 20460368
Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expression.
Banerjee A, Meyer K, Mazumdar B, Ray RB, Ray R
J Virol. 2010
PubMed ID: 20357092
An inducible RNA interference system for the functional dissection of mouse embryogenesis.
Vidigal JA, Morkel M, Wittler L, Brouwer-Lehmitz A, Grote P, Macura K, Herrmann BG
Nucleic Acids Res. 2010
PubMed ID: 20350929
Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells.
Dayoub R, Groitl P, Dobner T, Bosserhoff AK, Schlitt HJ, Weiss TS
Biochem Biophys Res Commun. 2010
PubMed ID: 20382118
Foxa1 and Foxa2 regulate bile duct development in mice.
Strazzabosco M
J Hepatol. 2010
PubMed ID: 20347503
Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo.
Miura S, Singh AP, Mishina Y
Dev Biol. 2010
PubMed ID: 20211162
FoxP1 promotes midbrain identity in embryonic stem cell-derived dopamine neurons by regulating Pitx3.
Konstantoulas CJ, Parmar M, Li M
J Neurochem. 2010
PubMed ID: 20175877
Tissue-specific Forkhead protein FOXA2 up-regulates SOX14 gene expression.
Popovic J, Klajn A, Petrovic I, Stevanovic M
Biochim Biophys Acta. 2010
PubMed ID: 20074681
Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival.
Lee HS, Bae EJ, Yi SH, Shim JW, Jo AY, Kang JS, Yoon EH, Rhee YH, Park CH, Koh HC, Kim HJ, Choi HS, Han JW, Lee YS, Kim J, Li JY, Brundin P, Lee SH
Stem Cells. 2010
PubMed ID: 20049900
PCP effector gene Inturned is an important regulator of cilia formation and embryonic development in mammals.
Zeng H, Hoover AN, Liu A
Dev Biol. 2010
PubMed ID: 20067783
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.
Xing C, Cohen JC, Boerwinkle E
Am J Hum Genet. 2010
PubMed ID: 20152958
Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer.
Song Y, Washington MK, Crawford HC
Cancer Res. 2010
PubMed ID: 20160041
Dynamic expression of Groucho-related genes Grg1 and Grg3 in foregut endoderm and antagonism of differentiation.
Santisteban P, Recacha P, Metzger DE, Zaret KS
Dev Dyn. 2010
PubMed ID: 20108349
Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon.
Nakatani T, Kumai M, Mizuhara E, Minaki Y, Ono Y
Dev Biol. 2010
PubMed ID: 20035737
Genetic predictors of interindividual variability in hepatic CYP3A4 expression.
Lamba V, Panetta JC, Strom S, Schuetz EG
J Pharmacol Exp Ther. 2010
PubMed ID: 19934400
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.
Ko HW, Norman RX, Tran J, Fuller KP, Fukuda M, Eggenschwiler JT
Dev Cell. 2010
PubMed ID: 20159594
Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm.
McKnight KD, Hou J, Hoodless PA
Dev Biol. 2010
PubMed ID: 19896480
Inhibition of the liver enriched protein FOXA2 recovers HNF6 activity in human colon carcinoma and liver hepatoma cells.
Lehner F, Kulik U, Klempnauer J, Borlak J
PLoS One. 2010
PubMed ID: 20967225
Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse.
Migeotte I, Omelchenko T, Hall A, Anderson KV
PLoS Biol. 2010
PubMed ID: 20689803
ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.
Zhang Y, Ali TZ, Zhou H, D'Souza DR, Lu Y, Jaffe J, Liu Z, Passaniti A, Hamburger AW
Cancer Res. 2010
PubMed ID: 20048076
Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D
Development. 2010
PubMed ID: 20040491
Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus.
Ustiyan V, Wang IC, Ren X, Zhang Y, Snyder J, Xu Y, Wert SE, Lessard JL, Kalin TV, Kalinichenko VV
Dev Biol. 2009
PubMed ID: 19835856
Regulation of adaptive behaviour during fasting by hypothalamic Foxa2.
Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M
Nature. 2009
PubMed ID: 19956259
Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes.
Farkas DR, Chapman DL
Dev Dyn. 2009
PubMed ID: 19877283
Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouse.
Heydeck W, Zeng H, Liu A
Dev Dyn. 2009
PubMed ID: 19877275
Organization of the human embryonic ventral mesencephalon.
Nelander J, Hebsgaard JB, Parmar M
Gene Expr Patterns. 2009
PubMed ID: 19825428
Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse.
Oh S, Lee D, Kim T, Kim TS, Oh HJ, Hwang CY, Kong YY, Kwon KS, Lim DS
Mol Cell Biol. 2009
PubMed ID: 19786569
Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools.
Joksimovic M, Anderegg A, Roy A, Campochiaro L, Yun B, Kittappa R, McKay R, Awatramani R
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19850875
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Retinoic acid signalling induces the differentiation of mouse fetal liver-derived hepatic progenitor cells.
Huang J, Bi Y, Zhu GH, He Y, Su Y, He BC, Wang Y, Kang Q, Chen L, Zuo GW, Luo Q, Shi Q, Zhang BQ, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N
Liver Int. 2009
PubMed ID: 19737349
Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain.
Stottmann RW, Tran PV, Turbe-Doan A, Beier DR
Dev Biol. 2009
PubMed ID: 19732765
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development.
Gray RS, Abitua PB, Wlodarczyk BJ, Szabo-Rogers HL, Blanchard O, Lee I, Weiss GS, Liu KJ, Marcotte EM, Wallingford JB, Finnell RH
Nat Cell Biol. 2009
PubMed ID: 19767740
Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord.
Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H
Mech Dev. 2009
PubMed ID: 19720144
Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.
Park SW, Verhaeghe C, Nguyenvu LT, Barbeau R, Eisley CJ, Nakagami Y, Huang X, Woodruff PG, Fahy JV, Erle DJ
Am J Respir Crit Care Med. 2009
PubMed ID: 19628779
Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm.
Acampora D, Di Giovannantonio LG, Di Salvio M, Mancuso P, Simeone A
Mech Dev. 2009
PubMed ID: 19615442
Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development.
Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL
Dev Biol. 2009
PubMed ID: 19607821
Nuclear export-independent inhibition of Foxa2 by insulin.
Howell JJ, Stoffel M
J Biol Chem. 2009
PubMed ID: 19589781
Wnt antagonist SFRP3 inhibits the differentiation of mouse hepatic progenitor cells.
Bi Y, Huang J, He Y, Zhu GH, Su Y, He BC, Luo J, Wang Y, Kang Q, Luo Q, Chen L, Zuo GW, Jiang W, Liu B, Shi Q, Tang M, Zhang BQ, Weng Y, Huang A, Zhou L, Feng T, Luu HH, Haydon RC, He TC, Tang N
J Cell Biochem. 2009
PubMed ID: 19562671
Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling.
Liem KF, He M, Ocbina PJ, Anderson KV
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666503
The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.
Endoh-Yamagami S, Evangelista M, Wilson D, Wen X, Theunissen JW, Phamluong K, Davis M, Scales SJ, Solloway MJ, de Sauvage FJ, Peterson AS
Curr Biol. 2009
PubMed ID: 19592253
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut.
Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE
Dev Cell. 2009
PubMed ID: 19686689
Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain.
Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W
Development. 2009
PubMed ID: 19592574
Induction of Wnt5a-expressing mesenchymal cells adjacent to the cloacal plate is an essential process for its proximodistal elongation and subsequent anorectal development.
Nakata M, Takada Y, Hishiki T, Saito T, Terui K, Sato Y, Koseki H, Yoshida H
Pediatr Res. 2009
PubMed ID: 19390486
The correlation of hepatocyte nuclear factor 4 alpha and 3 beta with hepatitis B virus replication in the liver of chronic hepatitis B patients.
Long Y, Chen E, Liu C, Huang F, Zhou T, He F, Liu L, Liu F, Tang H
J Viral Hepat. 2009
PubMed ID: 19302415
Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2.
Nock A, Ascano JM, Jones T, Barrero MJ, Sugiyama N, Tomita M, Ishihama Y, Malik S
J Biol Chem. 2009
PubMed ID: 19478084
Foxa2-dependent hepatic gene regulatory networks depend on physiological state.
Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH
Physiol Genomics. 2009
PubMed ID: 19417011
Tumour necrosis factor-alpha attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells.
Pandey AK, Bhardwaj V, Datta M
FEBS J. 2009
PubMed ID: 19769745
Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain.
Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J
Development. 2009
PubMed ID: 19542360
Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue.
Beites CL, Hollenbeck PL, Kim J, Lovell-Badge R, Lander AD, Calof AL
Development. 2009
PubMed ID: 19474151
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.
Su N, Thiaville MM, Awad K, Gjymishka A, Brant JO, Yang TP, Kilberg MS
Hepatology. 2009
PubMed ID: 19415718
Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.
Wandzioch E, Zaret KS
Science. 2009
PubMed ID: 19556507
SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3beta.
Freitas HS, Schaan BD, David-Silva A, Sabino-Silva R, Okamoto MM, Alves-Wagner AB, Mori RC, Machado UF
Mol Cell Endocrinol. 2009
PubMed ID: 19433262
Multiple roles of beta-catenin in controlling the neurogenic niche for midbrain dopamine neurons.
Tang M, Miyamoto Y, Huang EJ
Development. 2009
PubMed ID: 19439492
Foxa1 and Foxa2 regulate bile duct development in mice.
Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH
J Clin Invest. 2009
PubMed ID: 19436110
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.
Norman RX, Ko HW, Huang V, Eun CM, Abler LL, Zhang Z, Sun X, Eggenschwiler JT
Hum Mol Genet. 2009
PubMed ID: 19286674
Requirement for Shh and Fox family genes at different stages in sweat gland development.
Kunisada M, Cui CY, Piao Y, Ko MS, Schlessinger D
Hum Mol Genet. 2009
PubMed ID: 19270025
Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.
Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN
Hum Mol Genet. 2009
PubMed ID: 19223390
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.
Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J
Development. 2009
PubMed ID: 19369400
Tulp3 is a critical repressor of mouse hedgehog signaling.
Cameron DA, Pennimpede T, Petkovich M
Dev Dyn. 2009
PubMed ID: 19334287
Shh dependent and independent maintenance of basal midbrain.
Perez-Balaguer A, Puelles E, Wurst W, Martinez S
Mech Dev. 2009
PubMed ID: 19298856
Regulation of planar cell polarity by Smurf ubiquitin ligases.
Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL
Cell. 2009
PubMed ID: 19379695
Early thyroid development requires a Tbx1-Fgf8 pathway.
Lania G, Zhang Z, Huynh T, Caprio C, Moon AM, Vitelli F, Baldini A
Dev Biol. 2009
PubMed ID: 19389367
Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA.
Sekiya T, Muthurajan UM, Luger K, Tulin AV, Zaret KS
Genes Dev. 2009
PubMed ID: 19339686
Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.
Matsuyama M, Aizawa S, Shimono A
PLoS Genet. 2009
PubMed ID: 19300477
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo.
Burtscher I, Lickert H
Development. 2009
PubMed ID: 19234065
The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
Guelman S, Kozuka K, Mao Y, Pham V, Solloway MJ, Wang J, Wu J, Lill JR, Zha J
Mol Cell Biol. 2009
PubMed ID: 19103755
Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis.
Aoto K, Shikata Y, Imai H, Matsumaru D, Tokunaga T, Shioda S, Yamada G, Motoyama J
Dev Biol. 2009
PubMed ID: 19103193
Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.
Yu X, Wang Y, Jiang M, Bierie B, Roy-Burman P, Shen MM, Taketo MM, Wills M, Matusik RJ
Prostate. 2009
PubMed ID: 18991257
Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways.
Ribes V, Le Roux I, Rhinn M, Schuhbaur B, Dollé P
Development. 2009
PubMed ID: 19168680
Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis.
Joksimovic M, Yun BA, Kittappa R, Anderegg AM, Chang WW, Taketo MM, McKay RD, Awatramani RB
Nat Neurosci. 2009
PubMed ID: 19122665
Evidence that Fgf10 contributes to the skeletal and visceral defects of an apert syndrome mouse model.
Hajihosseini MK, Duarte R, Pegrum J, Donjacour A, Lana-Elola E, Rice DP, Sharpe J, Dickson C
Dev Dyn. 2009
PubMed ID: 18773495
Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.
Motallebipour M, Ameur A, Reddy Bysani MS, Patra K, Wallerman O, Mangion J, Barker MA, McKernan KJ, Komorowski J, Wadelius C
Genome Biol. 2009
PubMed ID: 19919681
Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons.
Hammond R, Blaess S, Abeliovich A
PLoS One. 2009
PubMed ID: 19774071
Transcriptional dynamics of endodermal organ formation.
Sherwood RI, Chen TY, Melton DA
Dev Dyn. 2009
PubMed ID: 19097184
Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.
Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A
Dev Biol. 2009
PubMed ID: 19000668
Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.
Gorivodsky M, Mukhopadhyay M, Wilsch-Braeuninger M, Phillips M, Teufel A, Kim C, Malik N, Huttner W, Westphal H
Dev Biol. 2009
PubMed ID: 18930042
Identification and characterization of VPO1, a new animal heme-containing peroxidase.
Cheng G, Salerno JC, Cao Z, Pagano PJ, Lambeth JD
Free Radic Biol Med. 2008
PubMed ID: 18929642
Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.
Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bösl MR, Fässler R, Lickert H, Klein R
Genes Dev. 2008
PubMed ID: 19056886
C2cd3 is required for cilia formation and Hedgehog signaling in mouse.
Hoover AN, Wynkoop A, Zeng H, Jia J, Niswander LA, Liu A
Development. 2008
PubMed ID: 19004860
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding.
Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, Cezard T, Fejes AP, Wederell ED, Cullum R, Euskirchen G, Krzywinski M, Birol I, Snyder M, Hoodless PA, Hirst M, Marra MA, Jones SJ
Genome Res. 2008
PubMed ID: 18787082
Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner.
Ishimura A, Chida S, Osada S
Dev Dyn. 2008
PubMed ID: 18697220
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner.
Yu W, McDonnell K, Taketo MM, Bai CB
Development. 2008
PubMed ID: 18927156
An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart.
Park EJ, Watanabe Y, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM
Development. 2008
PubMed ID: 18832392
Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.
Goller T, Vauti F, Ramasamy S, Arnold HH
Mol Cell Biol. 2008
PubMed ID: 18794365
Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C
PLoS Genet. 2008
PubMed ID: 18974875
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.
Omodei D, Acampora D, Mancuso P, Prakash N, Di Giovannantonio LG, Wurst W, Simeone A
Development. 2008
PubMed ID: 18820178
A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm.
Uetzmann L, Burtscher I, Lickert H
Genesis. 2008
PubMed ID: 18798232
Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis.
Li Y, Gordon J, Manley NR, Litingtung Y, Chiang C
Dev Biol. 2008
PubMed ID: 18692041
Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation.
Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM
Hum Mol Genet. 2008
PubMed ID: 18617531
Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis.
Ribes V, Stutzmann F, Bianchetti L, Guillemot F, Dollé P, Le Roux I
Dev Biol. 2008
PubMed ID: 18590718
Induction of sodium iodide symporter gene and molecular characterisation of HNF3 beta/FoxA2, TTF-1 and C/EBP beta in thyroid carcinoma cells.
Akagi T, Luong QT, Gui D, Said J, Selektar J, Yung A, Bunce CM, Braunstein GD, Koeffler HP
Br J Cancer. 2008
PubMed ID: 18682709
Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo.
Uez N, Lickert H, Kohlhase J, de Angelis MH, Kühn R, Wurst W, Floss T
Genesis. 2008
PubMed ID: 18781635
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.
García-García MJ, Shibata M, Anderson KV
Development. 2008
PubMed ID: 18701545
FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism.
Cho A, Ko HW, Eggenschwiler JT
Dev Biol. 2008
PubMed ID: 18590716
Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I
Mol Cell. 2008
PubMed ID: 18722179
A molecular program for contralateral trajectory: Rig-1 control by LIM homeodomain transcription factors.
Wilson SI, Shafer B, Lee KJ, Dodd J
Neuron. 2008
PubMed ID: 18701067
Hepatic differentiation of human bone marrow-derived mesenchymal stem cells by tetracycline-regulated hepatocyte nuclear factor 3beta.
Ishii K, Yoshida Y, Akechi Y, Sakabe T, Nishio R, Ikeda R, Terabayashi K, Matsumi Y, Gonda K, Okamoto H, Takubo K, Tajima F, Tsuchiya H, Hoshikawa Y, Kurimasa A, Umezawa A, Shiota G
Hepatology. 2008
PubMed ID: 18666263
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH
Nat Med. 2008
PubMed ID: 18660816
Crucial role of vHNF1 in vertebrate hepatic specification.
Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S
Development. 2008
PubMed ID: 18635606
Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing.
Wederell ED, Bilenky M, Cullum R, Thiessen N, Dagpinar M, Delaney A, Varhol R, Zhao Y, Zeng T, Bernier B, Ingham M, Hirst M, Robertson G, Marra MA, Jones S, Hoodless PA
Nucleic Acids Res. 2008
PubMed ID: 18611952
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
Dasen JS, De Camilli A, Wang B, Tucker PW, Jessell TM
Cell. 2008
PubMed ID: 18662545
15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer.
Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, Walbroehl J, Löwenberg E, Golub T, Merchan J, Tenen DG, Markowitz SD, Halmos B
Cancer Res. 2008
PubMed ID: 18593902
Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.
Tuteja G, Jensen ST, White P, Kaestner KH
Nucleic Acids Res. 2008
PubMed ID: 18556755
Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine.
Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O
Cell Tissue Res. 2008
PubMed ID: 18478268
Foxa2 activity increases plasma high density lipoprotein levels by regulating apolipoprotein M.
Wolfrum C, Howell JJ, Ndungo E, Stoffel M
J Biol Chem. 2008
PubMed ID: 18381283
Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo.
Lupu F, Alves A, Anderson K, Doye V, Lacy E
Dev Cell. 2008
PubMed ID: 18539113
All-trans retinoic acid-induced ectopic limb and caudal structures: murine strain sensitivities and pathogenesis.
Liao X, Collins MD
Dev Dyn. 2008
PubMed ID: 18498097
FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.
Kamagate A, Qu S, Perdomo G, Su D, Kim DH, Slusher S, Meseck M, Dong HH
J Clin Invest. 2008
PubMed ID: 18497885
Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors.
Bonilla S, Hall AC, Pinto L, Attardo A, Götz M, Huttner WB, Arenas E
Glia. 2008
PubMed ID: 18351630
Forkhead box A2-mediated regulation of female-predominant expression of the mouse Cyp2b9 gene.
Hashita T, Sakuma T, Akada M, Nakajima A, Yamahara H, Ito S, Takesako H, Nemoto N
Drug Metab Dispos. 2008
PubMed ID: 18339816
Forkhead box transcription factors Foxa1 and Foxa2 are important regulators of Muc2 mucin expression in intestinal epithelial cells.
van der Sluis M, Vincent A, Bouma J, Male AK, van Goudoever JB, Renes IB, Van Seuningen I
Biochem Biophys Res Commun. 2008
PubMed ID: 18336786
Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice.
Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA
Dev Biol. 2008
PubMed ID: 18400219
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K
Cell Stem Cell. 2008
PubMed ID: 18462699
Dkk1 and Wnt3 interact to control head morphogenesis in the mouse.
Lewis SL, Khoo PL, De Young RA, Steiner K, Wilcock C, Mukhopadhyay M, Westphal H, Jamieson RV, Robb L, Tam PP
Development. 2008
PubMed ID: 18403408
Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.
Gontan C, de Munck A, Vermeij M, Grosveld F, Tibboel D, Rottier R
Dev Biol. 2008
PubMed ID: 18374910
Cited2 is required for fetal lung maturation.
Xu B, Qu X, Gu S, Doughman YQ, Watanabe M, Dunwoodie SL, Yang YC
Dev Biol. 2008
PubMed ID: 18358466
Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival.
Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H
Mol Cell Biol. 2008
PubMed ID: 18332127
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR
Nat Genet. 2008
PubMed ID: 18327258
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo.
Liguori GL, Borges AC, D'Andrea D, Liguoro A, Gonçalves L, Salgueiro AM, Persico MG, Belo JA
Dev Biol. 2008
PubMed ID: 18241853
Genetic interaction between members of the Vangl family causes neural tube defects in mice.
Torban E, Patenaude AM, Leclerc S, Rakowiecki S, Gauthier S, Andelfinger G, Epstein DJ, Gros P
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18296642
Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins.
Ha HY, Kim JB, Cho IH, Joo HJ, Kim KS, Lee KW, Sunwoo H, Im JY, Lee JK, Hong JH, Han PL
Proteomics. 2008
PubMed ID: 18324732
Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo.
Fukusumi Y, Naruse C, Asano M
Dev Dyn. 2008
PubMed ID: 18224709
Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube.
Wong RL, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH
Hum Mol Genet. 2008
PubMed ID: 18003640
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.
Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ
Development. 2008
PubMed ID: 18171685
System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice.
Park EJ, Sun X, Nichol P, Saijoh Y, Martin JF, Moon AM
Dev Dyn. 2008
PubMed ID: 18161057
Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
Lavado A, Lagutin OV, Oliver G
Development. 2008
PubMed ID: 18094027
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.
Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H
BMC Genomics. 2008
PubMed ID: 18973680
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo.
Andersson ER, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, Yamaguchi TP, Hall AC, Wurst W, Arenas E
PLoS ONE. 2008
PubMed ID: 18953410
SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains.
Minoo P, Hu L, Zhu N, Borok Z, Bellusci S, Groffen J, Kardassis D, Li C
Nucleic Acids Res. 2008
PubMed ID: 18003659
Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.
Yang G, Huang SC, Wu JY, Benz EJ
Blood. 2008
PubMed ID: 17715393
The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.
Kittappa R, Chang WW, Awatramani RB, McKay RD
PLoS Biol. 2007
PubMed ID: 18076286
Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms.
Yamanaka Y, Tamplin OJ, Beckers A, Gossler A, Rossant J
Dev Cell. 2007
PubMed ID: 18061569
Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development.
Andersson O, Bertolino P, Ibáñez CF
Dev Biol. 2007
PubMed ID: 17936261
Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis.
Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J
Nat Neurosci. 2007
PubMed ID: 17922007
Transcriptional regulation of aquaporin 3 by insulin.
Higuchi S, Kubota M, Iguchi K, Usui S, Kiho T, Hirano K
J Cell Biochem. 2007
PubMed ID: 17471492
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S
Nature. 2007
PubMed ID: 17882221
An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs.
Ahnfelt-Rønne J, Jørgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J
J Histochem Cytochem. 2007
PubMed ID: 17478445
Helt determines GABAergic over glutamatergic neuronal fate by repressing Ngn genes in the developing mesencephalon.
Nakatani T, Minaki Y, Kumai M, Ono Y
Development. 2007
PubMed ID: 17611227
Two distinct sources for a population of maturing axial progenitors.
Cambray N, Wilson V
Development. 2007
PubMed ID: 17611225
Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner.
Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL
Development. 2007
PubMed ID: 17596284
A multipotent progenitor domain guides pancreatic organogenesis.
Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA
Dev Cell. 2007
PubMed ID: 17609113
Ftm is a novel basal body protein of cilia involved in Shh signalling.
Vierkotten J, Dildrop R, Peters T, Wang B, Rüther U
Development. 2007
PubMed ID: 17553904
Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.
Inoue T, Ota M, Mikoshiba K, Aruga J
Dev Biol. 2007
PubMed ID: 17490632
Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord.
Huang X, Litingtung Y, Chiang C
Development. 2007
PubMed ID: 17507410
Distinct functions of the major Fgf8 spliceform, Fgf8b, before and during mouse gastrulation.
Guo Q, Li JY
Development. 2007
PubMed ID: 17507393
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development.
Allen BL, Tenzen T, McMahon AP
Genes Dev. 2007
PubMed ID: 17504941
Gas1 extends the range of Hedgehog action by facilitating its signaling.
Martinelli DC, Fan CM
Genes Dev. 2007
PubMed ID: 17504940
The graded response to Sonic Hedgehog depends on cilia architecture.
Caspary T, Larkins CE, Anderson KV
Dev Cell. 2007
PubMed ID: 17488627
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning.
Vokes SA, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, Longabaugh WJ, Davidson EH, Wong WH, McMahon AP
Development. 2007
PubMed ID: 17442700
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.
Shu W, Lu MM, Zhang Y, Tucker PW, Zhou D, Morrisey EE
Development. 2007
PubMed ID: 17428829
Activation of Class I transcription factors by low level Sonic hedgehog signaling is mediated by Gli2-dependent and independent mechanisms.
Pachikara A, Dolson DK, Martinu L, Riccomagno MM, Jeong Y, Epstein DJ
Dev Biol. 2007
PubMed ID: 17321515
The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases.
Lehner F, Kulik U, Klempnauer J, Borlak J
FASEB J. 2007
PubMed ID: 17283222
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.
Kimura-Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, Aizawa S, Matsuo I
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17389379
System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate.
Frank DU, Elliott SA, Park EJ, Hammond J, Saijoh Y, Moon AM
Dev Dyn. 2007
PubMed ID: 17304540
Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia.
Li Y, Litingtung Y, Ten Dijke P, Chiang C
Dev Dyn. 2007
PubMed ID: 17260385
Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells.
Minoo P, Hu L, Xing Y, Zhu NL, Chen H, Li M, Borok Z, Li C
Mol Cell Biol. 2007
PubMed ID: 17220277
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system.
Hertzano R, Dror AA, Montcouquiol M, Ahmed ZM, Ellsworth B, Camper S, Friedman TB, Kelley MW, Avraham KB
Eur J Neurosci. 2007
PubMed ID: 17331196
BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis.
Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y
Dev Dyn. 2007
PubMed ID: 17117439
Role for Fox-1/Fox-2 in mediating the neuronal pathway of calcitonin/calcitonin gene-related peptide alternative RNA processing.
Zhou HL, Baraniak AP, Lou H
Mol Cell Biol. 2007
PubMed ID: 17101796
Hippi is essential for node cilia assembly and Sonic hedgehog signaling.
Houde C, Dickinson RJ, Houtzager VM, Cullum R, Montpetit R, Metzler M, Simpson EM, Roy S, Hayden MR, Hoodless PA, Nicholson DW
Dev Biol. 2006
PubMed ID: 17027958
Boc is a receptor for sonic hedgehog in the guidance of commissural axons.
Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre PJ, Tessier-Lavigne M, McConnell SK
Nature. 2006
PubMed ID: 17086203
Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development.
Sala FG, Curtis JL, Veltmaat JM, Del Moral PM, Le LT, Fairbanks TJ, Warburton D, Ford H, Wang K, Burns RC, Bellusci S
Dev Biol. 2006
PubMed ID: 16956603
Essential pro-Bmp roles of crossveinless 2 in mouse organogenesis.
Ikeya M, Kawada M, Kiyonari H, Sasai N, Nakao K, Furuta Y, Sasai Y
Development. 2006
PubMed ID: 17035289
BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.
Miura S, Davis S, Klingensmith J, Mishina Y
Development. 2006
PubMed ID: 16943278
The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis.
Yu X, Suzuki K, Wang Y, Gupta A, Jin R, Orgebin-Crist MC, Matusik R
Mol Endocrinol. 2006
PubMed ID: 16740652
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives.
Wang Z, Dollé P, Cardoso WV, Niederreither K
Dev Biol. 2006
PubMed ID: 16806149
Disruption of early proximodistal patterning and AVE formation in Apc mutants.
Chazaud C, Rossant J
Development. 2006
PubMed ID: 16887818
Plasticity and expanding complexity of the hepatic transcription factor network during liver development.
Kyrmizi I, Hatzis P, Katrakili N, Tronche F, Gonzalez FJ, Talianidis I
Genes Dev. 2006
PubMed ID: 16912278
Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
Asayesh A, Sharpe J, Watson RP, Hecksher-Sørensen J, Hastie ND, Hill RE, Ahlgren U
Genes Dev. 2006
PubMed ID: 16912273
Roles of organizer factors and BMP antagonism in mammalian forebrain establishment.
Yang YP, Klingensmith J
Dev Biol. 2006
PubMed ID: 16839541
Identification of potential target genes for RFX4_v3, a transcription factor critical for brain development.
Zhang D, Stumpo DJ, Graves JP, DeGraff LM, Grissom SF, Collins JB, Li L, Zeldin DC, Blackshear PJ
J Neurochem. 2006
PubMed ID: 16893423
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching.
Rakeman AS, Anderson KV
Development. 2006
PubMed ID: 16831833
The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells.
Lavon N, Yanuka O, Benvenisty N
Stem Cells. 2006
PubMed ID: 16675598
Absence of Nodal signaling promotes precocious neural differentiation in the mouse embryo.
Camus A, Perea-Gomez A, Moreau A, Collignon J
Dev Biol. 2006
PubMed ID: 16678814
Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells.
Cheng A, Zhang M, Crosson SM, Bao ZQ, Saltiel AR
Endocrinology. 2006
PubMed ID: 16627590
Expression and role of Foxa proteins in prostate cancer.
Mirosevich J, Gao N, Gupta A, Shappell SB, Jove R, Matusik RJ
Prostate. 2006
PubMed ID: 16001449
Synergistic interaction between Gdf1 and Nodal during anterior axis development.
Andersson O, Reissmann E, Jörnvall H, Ibáñez CF
Dev Biol. 2006
PubMed ID: 16564040
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice.
Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP
Dev Cell. 2006
PubMed ID: 16647304
Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border.
Griesel G, Treichel D, Collombat P, Krull J, Zembrzycki A, van den Akker WM, Gruss P, Simeone A, Mansouri A
Development. 2006
PubMed ID: 16571633
Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung.
del Moral PM, De Langhe SP, Sala FG, Veltmaat JM, Tefft D, Wang K, Warburton D, Bellusci S
Dev Biol. 2006
PubMed ID: 16494859
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.
Isono K, Nemoto K, Li Y, Takada Y, Suzuki R, Katsuki M, Nakagawara A, Koseki H
Mol Cell Biol. 2006
PubMed ID: 16537918
FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis.
Berg DT, Gerlitz B, Sharma GR, Richardson MA, Stephens EJ, Grubbs RL, Holmes KC, Fynboe K, Montani D, Cramer MS, Engle SD, Jakubowski JA, Heuer JG, Grinnell BW
Clin Vaccine Immunol. 2006
PubMed ID: 16522789
C/EBPalpha is required for lung maturation at birth.
Martis PC, Whitsett JA, Xu Y, Perl AK, Wan H, Ikegami M
Development. 2006
PubMed ID: 16467360
Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells.
Eblaghie MC, Reedy M, Oliver T, Mishina Y, Hogan BL
Dev Biol. 2006
PubMed ID: 16414041
Zic3 is critical for early embryonic patterning during gastrulation.
Ware SM, Harutyunyan KG, Belmont JW
Dev Dyn. 2006
PubMed ID: 16397896
Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells.
Matsuura R, Kogo H, Ogaeri T, Miwa T, Kuwahara M, Kanai Y, Nakagawa T, Kuroiwa A, Fujimoto T, Torihashi S
Stem Cells. 2006
PubMed ID: 16210401
Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.
Wolfrum C, Stoffel M
Cell Metab. 2006
PubMed ID: 16459311
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.
Svärd J, Heby-Henricson K, Henricson KH, Persson-Lek M, Rozell B, Lauth M, Bergström A, Ericson J, Toftgård R, Teglund S
Dev Cell. 2006
PubMed ID: 16459298
Motoneurons and oligodendrocytes are sequentially generated from neural stem cells but do not appear to share common lineage-restricted progenitors in vivo.
Wu S, Wu Y, Capecchi MR
Development. 2006
PubMed ID: 16407399
Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins.
Eggenschwiler JT, Bulgakov OV, Qin J, Li T, Anderson KV
Dev Biol. 2006
PubMed ID: 16364285
Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.
Bort R, Signore M, Tremblay K, Martinez Barbera JP, Zaret KS
Dev Biol. 2006
PubMed ID: 16364283
Expression and functional analysis of Tgif during mouse midline development.
Jin JZ, Gu S, McKinney P, Ding J
Dev Dyn. 2006
PubMed ID: 16284942
Identification of forkhead transcription factors in cortical and dopaminergic areas of the adult murine brain.
Wijchers PJ, Hoekman MF, Burbach JP, Smidt MP
Brain Res. 2006
PubMed ID: 16376864
Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.
Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A
Int J Dev Biol. 2006
PubMed ID: 16892178
The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.
Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW
Development. 2006
PubMed ID: 16368929
Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition.
Reiter JF, Skarnes WC
Genes Dev. 2006
PubMed ID: 16357211
Foxa1 and Foxa2 interact with the androgen receptor to regulate prostate and epididymal genes differentially.
Yu X, Gupta A, Wang Y, Suzuki K, Mirosevich J, Orgebin-Crist MC, Matusik RJ
Ann N Y Acad Sci. 2005
PubMed ID: 16467259
Wnt3a links left-right determination with segmentation and anteroposterior axis elongation.
Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP
Development. 2005
PubMed ID: 16291790
Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis.
Chu J, Ding J, Jeays-Ward K, Price SM, Placzek M, Shen MM
Development. 2005
PubMed ID: 16291788
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.
Kimura-Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo JA, Aizawa S, Matsui Y, Matsuo I
Dev Cell. 2005
PubMed ID: 16256739
Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1.
Besnard V, Wert SE, Kaestner KH, Whitsett JA
Am J Physiol Lung Cell Mol Physiol. 2005
PubMed ID: 16214823
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor.
Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, Nishioka N, Kondoh H, Sasaki H
Development. 2005
PubMed ID: 16207754
Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused.
Cooper AF, Yu KP, Brueckner M, Brailey LL, Johnson L, McGrath JM, Bale AE
Development. 2005
PubMed ID: 16155214
Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1.
Ivins S, Lammerts van Beuren K, Roberts C, James C, Lindsay E, Baldini A, Ataliotis P, Scambler PJ
Dev Biol. 2005
PubMed ID: 16109395
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Cilia and Hedgehog responsiveness in the mouse.
Huangfu D, Anderson KV
Proc Natl Acad Sci U S A. 2005
PubMed ID: 16061793
Foxa2 integrates the transcriptional response of the hepatocyte to fasting.
Zhang L, Rubins NE, Ahima RS, Greenbaum LE, Kaestner KH
Cell Metab. 2005
PubMed ID: 16098831
Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2.
Rubins NE, Friedman JR, Le PP, Zhang L, Brestelli J, Kaestner KH
Mol Cell Biol. 2005
PubMed ID: 16055718
Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.
Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL
Development. 2005
PubMed ID: 15987774
Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation.
Gao N, Ishii K, Mirosevich J, Kuwajima S, Oppenheimer SR, Roberts RL, Jiang M, Yu X, Shappell SB, Caprioli RM, Stoffel M, Hayward SW, Matusik RJ
Development. 2005
PubMed ID: 15987773
The initiation of liver development is dependent on Foxa transcription factors.
Lee CS, Friedman JR, Fulmer JT, Kaestner KH
Nature. 2005
PubMed ID: 15959514
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.
Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV
J Biol Chem. 2005
PubMed ID: 15817462
Smad1 and Smad8 function similarly in mammalian central nervous system development.
Hester M, Thompson JC, Mills J, Liu Y, El-Hodiri HM, Weinstein M
Mol Cell Biol. 2005
PubMed ID: 15899870
Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.
Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H
Development. 2005
PubMed ID: 15857913
Homozygous Ft embryos are affected in floor plate maintenance and ventral neural tube patterning.
Götz K, Briscoe J, Rüther U
Dev Dyn. 2005
PubMed ID: 15789444
Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome.
Prescott K, Ivins S, Hubank M, Lindsay E, Baldini A, Scambler P
Hum Genet. 2005
PubMed ID: 15778864
A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.
Verschuur M, de Jong M, Felida L, de Maat MP, Vos HL
J Biol Chem. 2005
PubMed ID: 15737987
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
Wan H, Dingle S, Xu Y, Besnard V, Kaestner KH, Ang SL, Wert S, Stahlman MT, Whitsett JA
J Biol Chem. 2005
PubMed ID: 15668254
Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development.
Molotkov A, Molotkova N, Duester G
Dev Dyn. 2005
PubMed ID: 15739227
Expression of Foxa transcription factors in the developing and adult murine prostate.
Mirosevich J, Gao N, Matusik RJ
Prostate. 2005
PubMed ID: 15389796
Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo.
Woda JM, Calzonetti T, Hilditch-Maguire P, Duyao MP, Conlon RA, MacDonald ME
BMC Dev Biol. 2005
PubMed ID: 16109169
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
LRP2/megalin is required for patterning of the ventral telencephalon.
Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE
Development. 2005
PubMed ID: 15623804
Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand.
Tian H, Jeong J, Harfe BD, Tabin CJ, McMahon AP
Development. 2005
PubMed ID: 15576405
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1.
Jeong J, McMahon AP
Development. 2005
PubMed ID: 15576403
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung.
Serls AE, Doherty S, Parvatiyar P, Wells JM, Deutsch GH
Development. 2005
PubMed ID: 15576401
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.
Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M
Nature. 2004
PubMed ID: 15616563
Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues.
Besnard V, Wert SE, Hull WM, Whitsett JA
Gene Expr Patterns. 2004
PubMed ID: 15567715
FoxA proteins regulate H19 endoderm enhancer E1 and exhibit developmental changes in enhancer binding in vivo.
Long L, Spear BT
Mol Cell Biol. 2004
PubMed ID: 15485926
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors.
Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D
Development. 2004
PubMed ID: 15469978
Foxa2 is required for transition to air breathing at birth.
Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, Whitsett JA
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15452354
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates.
Rana AA, Barbera JP, Rodriguez TA, Lynch D, Hirst E, Smith JC, Beddington RS
Development. 2004
PubMed ID: 15371312
Regionalization of cell fates and cell movement in the endoderm of the mouse gastrula and the impact of loss of Lhx1(Lim1) function.
Tam PP, Khoo PL, Wong N, Tsang TE, Behringer RR
Dev Biol. 2004
PubMed ID: 15355796
The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.
Hecksher-Sørensen J, Watson RP, Lettice LA, Serup P, Eley L, De Angelis C, Ahlgren U, Hill RE
Development. 2004
PubMed ID: 15329346
Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning.
Lu CC, Robertson EJ
Dev Biol. 2004
PubMed ID: 15302604
Lhx2 is expressed in the septum transversum mesenchyme that becomes an integral part of the liver and the formation of these cells is independent of functional Lhx2.
Kolterud A, Wandzioch E, Carlsson L
Gene Expr Patterns. 2004
PubMed ID: 15261829
Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.
Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ
Development. 2004
PubMed ID: 15215210
The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.
Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Müller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A
Genes Dev. 2004
PubMed ID: 15231714
Hepatic nuclear factor 3 and nuclear factor 1 regulate 5-aminolevulinate synthase gene expression and are involved in insulin repression.
Scassa ME, Guberman AS, Ceruti JM, Cánepa ET
J Biol Chem. 2004
PubMed ID: 15123725
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Lu X, Borchers AG, Jolicoeur C, Rayburn H, Baker JC, Tessier-Lavigne M
Nature. 2004
PubMed ID: 15229603
Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo.
Hu Q, Ueno N, Behringer RR
EMBO Rep. 2004
PubMed ID: 15218525
A transcriptional profiling study of CCAAT/enhancer binding protein targets identifies hepatocyte nuclear factor 3 beta as a novel tumor suppressor in lung cancer.
Halmos B, Bassères DS, Monti S, D'Aló F, Dayaram T, Ferenczi K, Wouters BJ, Huettner CS, Golub TR, Tenen DG
Cancer Res. 2004
PubMed ID: 15205324
Smad2 and Smad3 coordinately regulate craniofacial and endodermal development.
Liu Y, Festing M, Thompson JC, Hester M, Rankin S, El-Hodiri HM, Zorn AM, Weinstein M
Dev Biol. 2004
PubMed ID: 15183723
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice.
Kelly OG, Pinson KI, Skarnes WC
Development. 2004
PubMed ID: 15142971
Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis.
Li Y, Zhang H, Choi SC, Litingtung Y, Chiang C
Dev Biol. 2004
PubMed ID: 15136151
The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element.
Paré JF, Malenfant D, Courtemanche C, Jacob-Wagner M, Roy S, Allard D, Bélanger L
J Biol Chem. 2004
PubMed ID: 15014077
FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.
Bulgakov OV, Eggenschwiler JT, Hong DH, Anderson KV, Li T
Development. 2004
PubMed ID: 15105374
Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain.
Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A
Development. 2004
PubMed ID: 15105370
Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.
Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK
Development. 2004
PubMed ID: 15084457
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.
Chen MH, Li YJ, Kawakami T, Xu SM, Chuang PT
Genes Dev. 2004
PubMed ID: 15075292
Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes.
Jochheim A, Hillemann T, Kania G, Scharf J, Attaran M, Manns MP, Wobus AM, Ott M
Int J Dev Biol. 2004
PubMed ID: 15005571
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson PC, Rothenberg ME, Whitsett JA
Development. 2004
PubMed ID: 14757645
The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.
Vavricka SR, Jung D, Fried M, Grützner U, Meier PJ, Kullak-Ublick GA
J Hepatol. 2004
PubMed ID: 14739090
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.
Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS
Development. 2004
PubMed ID: 14736744
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
Yoshitomi H, Zaret KS
Development. 2004
PubMed ID: 14736742
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Tcf3: a transcriptional regulator of axis induction in the early embryo.
Merrill BJ, Pasolli HA, Polak L, Rendl M, García-García MJ, Anderson KV, Fuchs E
Development. 2004
PubMed ID: 14668413
Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis.
Zoltewicz JS, Stewart NJ, Leung R, Peterson AS
Development. 2004
PubMed ID: 14645126
The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis.
DeYoung RA, Baker JC, Cado D, Winoto A
J Biol Chem. 2003
PubMed ID: 13129926
Hedgehog signalling in the mouse requires intraflagellar transport proteins.
Huangfu D, Liu A, Rakeman AS, Murcia NS, Niswander L, Anderson KV
Nature. 2003
PubMed ID: 14603322
Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.
Wolfrum C, Besser D, Luca E, Stoffel M
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14500912
Dkk1 and noggin cooperate in mammalian head induction.
del Barco Barrantes I, Davidson G, Gröne HJ, Westphal H, Niehrs C
Genes Dev. 2003
PubMed ID: 12952897
Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1.
Kokubu C, Wilm B, Kokubu T, Wahl M, Rodrigo I, Sakai N, Santagati F, Hayashizaki Y, Suzuki M, Yamamura K, Abe K, Imai K
Genetics. 2003
PubMed ID: 14504237
Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage.
Miura S, Mishina Y
Genesis. 2003
PubMed ID: 14502576
Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling.
Robertson EJ, Norris DP, Brennan J, Bikoff EK
Philos Trans R Soc Lond B Biol Sci. 2003
PubMed ID: 14511481
Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer.
Ceelie H, Spaargaren-Van Riel CC, De Jong M, Bertina RM, Vos HL
J Thromb Haemost. 2003
PubMed ID: 12911579
Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node.
Jeong Y, Epstein DJ
Development. 2003
PubMed ID: 12835403
Cell fate decisions within the mouse organizer are governed by graded Nodal signals.
Vincent SD, Dunn NR, Hayashi S, Norris DP, Robertson EJ
Genes Dev. 2003
PubMed ID: 12842913
Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification.
Motoyama J, Milenkovic L, Iwama M, Shikata Y, Scott MP, Hui CC
Dev Biol. 2003
PubMed ID: 12812795
The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade.
Jacquemin P, Lemaigre FP, Rousseau GG
Dev Biol. 2003
PubMed ID: 12781686
Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage.
Hughes DE, Stolz DB, Yu S, Tan Y, Reddy JK, Watkins SC, Diehl AM, Costa RH
Hepatology. 2003
PubMed ID: 12774021
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons.
Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR
Cell. 2003
PubMed ID: 12787506
Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain.
Puelles E, Acampora D, Lacroix E, Signore M, Annino A, Tuorto F, Filosa S, Corte G, Wurst W, Ang SL, Simeone A
Nat Neurosci. 2003
PubMed ID: 12652306
Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors.
Foucher I, Montesinos ML, Volovitch M, Prochiantz A, Trembleau A
Development. 2003
PubMed ID: 12642491
Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1.
Abu-Abed S, Dollé P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M
Development. 2003
PubMed ID: 12588859
The zinc-finger protein CNBP is required for forebrain formation in the mouse.
Chen W, Liang Y, Deng W, Shimizu K, Ashique AM, Li E, Li YP
Development. 2003
PubMed ID: 12588852
Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve.
Pabst O, Rummelies J, Winter B, Arnold HH
Development. 2003
PubMed ID: 12571110
Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation.
Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H
Development. 2003
PubMed ID: 12490556
Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer.
Yamagishi H, Maeda J, Hu T, McAnally J, Conway SJ, Kume T, Meyers EN, Yamagishi C, Srivastava D
Genes Dev. 2003
PubMed ID: 12533514
Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.
Rausa FM, Tan Y, Costa RH
Mol Cell Biol. 2003
PubMed ID: 12509444
Node and midline defects are associated with left-right development in Delta1 mutant embryos.
Przemeck GK, Heinzmann U, Beckers J, Hrabé de Angelis M
Development. 2003
PubMed ID: 12441287
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.
Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM
Science. 2002
PubMed ID: 12471260
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Extraembryonic proteases regulate Nodal signalling during gastrulation.
Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB
Nat Cell Biol. 2002
PubMed ID: 12447384
Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo.
Banks KE, Anderson AL, Tang H, Hughes DE, Costa RH, McLachlan A
J Virol. 2002
PubMed ID: 12438623
Mouse dispatched mutants fail to distribute hedgehog proteins and are defective in hedgehog signaling.
Kawakami T, Kawcak T, Li YJ, Zhang W, Hu Y, Chuang PT
Development. 2002
PubMed ID: 12421714
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity.
Persson M, Stamataki D, te Welscher P, Andersson E, Böse J, Rüther U, Ericson J, Briscoe J
Genes Dev. 2002
PubMed ID: 12435629
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord.
Wijgerde M, McMahon JA, Rule M, McMahon AP
Genes Dev. 2002
PubMed ID: 12435628
Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.
Perea-Gomez A, Vella FD, Shawlot W, Oulad-Abdelghani M, Chazaud C, Meno C, Pfister V, Chen L, Robertson E, Hamada H, Behringer RR, Ang SL
Dev Cell. 2002
PubMed ID: 12431380
Chordin and noggin promote organizing centers of forebrain development in the mouse.
Anderson RM, Lawrence AR, Stottmann RW, Bachiller D, Klingensmith J
Development. 2002
PubMed ID: 12397106
Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched.
Ma Y, Erkner A, Gong R, Yao S, Taipale J, Basler K, Beachy PA
Cell. 2002
PubMed ID: 12372301
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway.
Bai CB, Auerbach W, Lee JS, Stephen D, Joyner AL
Development. 2002
PubMed ID: 12361967
Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm.
Burke Z, Oliver G
Mech Dev. 2002
PubMed ID: 12351178
SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast.
Hayashi K, Kobayashi T, Umino T, Goitsuka R, Matsui Y, Kitamura D
Mech Dev. 2002
PubMed ID: 12351174
Mouse Dispatched homolog1 is required for long-range, but not juxtacrine, Hh signaling.
Caspary T, García-García MJ, Huangfu D, Eggenschwiler JT, Wyler MR, Rakeman AS, Alcorn HL, Anderson KV
Curr Biol. 2002
PubMed ID: 12372258
Nodal activity in the node governs left-right asymmetry.
Brennan J, Norris DP, Robertson EJ
Genes Dev. 2002
PubMed ID: 12231623
Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors.
Foucher I, Volovitch M, Frain M, Kim JJ, Souberbielle JC, Gan L, Unterman TG, Prochiantz A, Trembleau A
Development. 2002
PubMed ID: 12163409
Foxa (HNF3) up-regulates vitronectin expression during retinoic acid-induced differentiation in mouse neuroblastoma Neuro2a cells.
Shimizu S, Kondo M, Miyamoto Y, Hayashi M
Cell Struct Funct. 2002
PubMed ID: 12441652
Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.
Hart AH, Hartley L, Sourris K, Stadler ES, Li R, Stanley EG, Tam PP, Elefanty AG, Robb L
Development. 2002
PubMed ID: 12117810
The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
Norris DP, Brennan J, Bikoff EK, Robertson EJ
Development. 2002
PubMed ID: 12091315
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.
Weidenfeld J, Shu W, Zhang L, Millar SE, Morrisey EE
J Biol Chem. 2002
PubMed ID: 11914369
The ion channel polycystin-2 is required for left-right axis determination in mice.
Pennekamp P, Karcher C, Fischer A, Schweickert A, Skryabin B, Horst J, Blum M, Dworniczak B
Curr Biol. 2002
PubMed ID: 12062060
Transcription factor AP-2gamma is essential in the extra-embryonic lineages for early postimplantation development.
Auman HJ, Nottoli T, Lakiza O, Winger Q, Donaldson S, Williams T
Development. 2002
PubMed ID: 12015300
Protein kinase A deficiency causes axially localized neural tube defects in mice.
Huang Y, Roelink H, McKnight GS
J Biol Chem. 2002
PubMed ID: 11886853
Depletion of definitive gut endoderm in Sox17-null mutant mice.
Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, Sanai Y, Yonekawa H, Yazaki K, Tam PP, Hayashi Y
Development. 2002
PubMed ID: 11973269
Optical projection tomography as a tool for 3D microscopy and gene expression studies.
Sharpe J, Ahlgren U, Perry P, Hill B, Ross A, Hecksher-Sørensen J, Baldock R, Davidson D
Science. 2002
PubMed ID: 11964482
Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development.
Kalinichenko VV, Zhou Y, Bhattacharyya D, Kim W, Shin B, Bambal K, Costa RH
J Biol Chem. 2002
PubMed ID: 11809759
The onecut transcription factor HNF6 is required for normal development of the biliary tract.
Clotman F, Lannoy VJ, Reber M, Cereghini S, Cassiman D, Jacquemin P, Roskams T, Rousseau GG, Lemaigre FP
Development. 2002
PubMed ID: 11934848
Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.
Faisst AM, Alvarez-Bolado G, Treichel D, Gruss P
Mech Dev. 2002
PubMed ID: 11900971
Targeted mutagenesis of the Hira gene results in gastrulation defects and patterning abnormalities of mesoendodermal derivatives prior to early embryonic lethality.
Roberts C, Sutherland HF, Farmer H, Kimber W, Halford S, Carey A, Brickman JM, Wynshaw-Boris A, Scambler PJ
Mol Cell Biol. 2002
PubMed ID: 11884616
Goosecoid and cerberus-like do not interact during mouse embryogenesis.
Borges AC, Marques S, Belo JA
Int J Dev Biol. 2002
PubMed ID: 11934155
Quaking is essential for blood vessel development.
Noveroske JK, Lai L, Gaussin V, Northrop JL, Nakamura H, Hirschi KK, Justice MJ
Genesis. 2002
PubMed ID: 11892011
Maintenance of the specification of the anterior definitive endoderm and forebrain depends on the axial mesendoderm: a study using HNF3beta/Foxa2 conditional mutants.
Hallonet M, Kaestner KH, Martin-Parras L, Sasaki H, Betz UA, Ang SL
Dev Biol. 2002
PubMed ID: 11846474
Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.
Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I
Dev Biol. 2002
PubMed ID: 11820816
The DNA sequence and comparative analysis of human chromosome 20.
Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J
Nature. 2001
PubMed ID: 11780052
Gli1 can rescue the in vivo function of Gli2.
Bai CB, Joyner AL
Development. 2001
PubMed ID: 11748151
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis.
Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R
Development. 2001
PubMed ID: 11748146
Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3beta: impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression.
Park SH, Waxman DJ
J Biol Chem. 2001
PubMed ID: 11562369
Hepatocyte nuclear factors-1alpha, -1beta, and -3beta expressed in the gonad of tilapia (Oreochromis mossambicus).
Huang WT, Gong HY, Lin CJ, Weng CF, Chen MH, Wu JL
Biochem Biophys Res Commun. 2001
PubMed ID: 11688983
Genetic evidence that Sil is required for the Sonic Hedgehog response pathway.
Izraeli S, Lowe LA, Bertness VL, Campaner S, Hahn H, Kirsch IR, Kuehn MR
Genesis. 2001
PubMed ID: 11668681
An enhancer sequence directs LacZ expression to developing pharyngeal endoderm in transgenic mice.
Parmar H, Coletta PL, Faruque N, Sharpe PT
Genesis. 2001
PubMed ID: 11668679
The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm.
Kinder SJ, Tsang TE, Wakamiya M, Sasaki H, Behringer RR, Nagy A, Tam PP
Development. 2001
PubMed ID: 11566865
Smad proteins and hepatocyte growth factor control parallel regulatory pathways that converge on beta1-integrin to promote normal liver development.
Weinstein M, Monga SP, Liu Y, Brodie SG, Tang Y, Li C, Mishra L, Deng CX
Mol Cell Biol. 2001
PubMed ID: 11438667
Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor.
Kalinichenko VV, Lim L, Stolz DB, Shin B, Rausa FM, Clark J, Whitsett JA, Watkins SC, Costa RH
Dev Biol. 2001
PubMed ID: 11437453
Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway.
Eggenschwiler JT, Espinoza E, Anderson KV
Nature. 2001
PubMed ID: 11449277
TGF-beta1 perturbs vascular development and inhibits epithelial differentiation in fetal lung in vivo.
Zeng X, Gray M, Stahlman MT, Whitsett JA
Dev Dyn. 2001
PubMed ID: 11458389
Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx.
Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S
Mol Cell Biol. 2001
PubMed ID: 11390666
Nodal signalling in the epiblast patterns the early mouse embryo.
Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ
Nature. 2001
PubMed ID: 11418863
Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations.
Mahlapuu M, Enerbäck S, Carlsson P
Development. 2001
PubMed ID: 11493558
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.
Hoodless PA, Pye M, Chazaud C, Labbé E, Attisano L, Rossant J, Wrana JL
Genes Dev. 2001
PubMed ID: 11358869
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.
Yamamoto M, Meno C, Sakai Y, Shiratori H, Mochida K, Ikawa Y, Saijoh Y, Hamada H
Genes Dev. 2001
PubMed ID: 11358868
Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK).
Xue Y, Wang X, Li Z, Gotoh N, Chapman D, Skolnik EY
Development. 2001
PubMed ID: 11290295
Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.
Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D
Nature. 2001
PubMed ID: 11298452
Role of accessory factors and steroid receptor coactivator 1 in the regulation of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids.
Stafford JM, Waltner-Law M, Granner DK
J Biol Chem. 2001
PubMed ID: 11069927
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Otx2 and HNF3beta genetically interact in anterior patterning.
Jin O, Harpal K, Ang SL, Rossant J
Int J Dev Biol. 2001
PubMed ID: 11291866
Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity.
Kinder SJ, Tsang TE, Ang SL, Behringer RR, Tam PP
Int J Dev Biol. 2001
PubMed ID: 11291865
Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation.
Chung AC, Katz D, Pereira FA, Jackson KJ, DeMayo FJ, Cooney AJ, O'Malley BW
Mol Cell Biol. 2001
PubMed ID: 11134352
Hoxb1 controls effectors of sonic hedgehog and Mash1 signaling pathways.
Gaufo GO, Flodby P, Capecchi MR
Development. 2000
PubMed ID: 11076756
Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.
Eggenschwiler JT, Anderson KV
Dev Biol. 2000
PubMed ID: 11071781
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.
Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M
Hum Hered. 2000
PubMed ID: 10899756
Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage.
Keng VW, Yagi H, Ikawa M, Nagano T, Myint Z, Yamada K, Tanaka T, Sato A, Muramatsu I, Okabe M, Sato M, Noguchi T
Biochem Biophys Res Commun. 2000
PubMed ID: 11027604
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development.
Xu W, Edmondson DG, Evrard YA, Wakamiya M, Behringer RR, Roth SY
Nat Genet. 2000
PubMed ID: 11017084
Transcriptional regulation of liver development.
Duncan SA
Dev Dyn. 2000
PubMed ID: 11002334
Visceral endoderm mediates forebrain development by suppressing posteriorizing signals.
Kimura C, Yoshinaga K, Tian E, Suzuki M, Aizawa S, Matsuo I
Dev Biol. 2000
PubMed ID: 10985852
Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse.
Welsh IC, O'Brien TP
Dev Biol. 2000
PubMed ID: 10964471
Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine.
Antes TJ, Goodart SA, Huynh C, Sullivan M, Young SG, Levy-Wilson B
J Biol Chem. 2000
PubMed ID: 10859308
MesP1 and MesP2 are essential for the development of cardiac mesoderm.
Kitajima S, Takagi A, Inoue T, Saga Y
Development. 2000
PubMed ID: 10887078
Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte.
Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH
Mol Cell Biol. 2000
PubMed ID: 10866673
Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta.
Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK
J Biol Chem. 2000
PubMed ID: 10748198
Conserved linkage of NK-2 homeobox gene pairs Nkx2-2/2-4 and Nkx2-1/2-9 in mammals.
Wang CC, Brodnicki T, Copeland NG, Jenkins NA, Harvey RP
Mamm Genome. 2000
PubMed ID: 10818213
The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation.
Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS
Development. 2000
PubMed ID: 10804184
The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.
Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP
Development. 2000
PubMed ID: 10804177
SPC4/PACE4 regulates a TGFbeta signaling network during axis formation.
Constam DB, Robertson EJ
Genes Dev. 2000
PubMed ID: 10809672
BMP type II receptor is required for gastrulation and early development of mouse embryos.
Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K
Dev Biol. 2000
PubMed ID: 10772805
Activity-regulated, cytoskeleton-associated protein (Arc) is essential for visceral endoderm organization during early embryogenesis.
Liu D, Bei D, Parmar H, Matus A
Mech Dev. 2000
PubMed ID: 10727859
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation.
Park HL, Bai C, Platt KA, Matise MP, Beeghly A, Hui CC, Nakashima M, Joyner AL
Development. 2000
PubMed ID: 10725236
The organizer factors Chordin and Noggin are required for mouse forebrain development.
Bachiller D, Klingensmith J, Kemp C, Belo JA, Anderson RM, May SR, McMahon JA, McMahon AP, Harland RM, Rossant J, De Robertis EM
Nature. 2000
PubMed ID: 10688202
OTX2 directly interacts with LIM1 and HNF-3beta.
Nakano T, Murata T, Matsuo I, Aizawa S
Biochem Biophys Res Commun. 2000
PubMed ID: 10623575
Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3 beta and mutation screening in Japanese subjects with maturity-onset diabetes of the young.
Yamada S, Zhu Q, Aihara Y, Onda H, Zhang Z, Yu L, Jin L, Si YJ, Nishigori H, Tomura H, Inoue I, Morikawa A, Yamagata K, Hanafusa T, Matsuzawa Y, Takeda J
Diabetologia. 2000
PubMed ID: 10672453
Neural induction and patterning in the mouse in the absence of the node and its derivatives.
Klingensmith J, Ang SL, Bachiller D, Rossant J
Dev Biol. 1999
PubMed ID: 10642791
Molecular mechanisms of liver development and differentiation.
Darlington GJ
Curr Opin Cell Biol. 1999
PubMed ID: 10600708
The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas.
Rausa FM, Galarneau L, Bélanger L, Costa RH
Mech Dev. 1999
PubMed ID: 10559496
Retinoic acid affects left-right patterning.
Wasiak S, Lohnes D
Dev Biol. 1999
PubMed ID: 10545241
Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells.
Rowitch DH, S-Jacques B, Lee SM, Flax JD, Snyder EY, McMahon AP
J Neurosci. 1999
PubMed ID: 10516314
HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.
Perea-Gómez A, Shawlot W, Sasaki H, Behringer RR, Ang S
Development. 1999
PubMed ID: 10498685
Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis.
Brown D, Wagner D, Li X, Richardson JA, Olson EN
Development. 1999
PubMed ID: 10477299
Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis.
Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisúa-Belmonte JC, Rosenfeld MG
Nature. 1999
PubMed ID: 10499586
HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo.
Tichelaar JW, Lim L, Costa RH, Whitsett JA
Dev Biol. 1999
PubMed ID: 10479457
Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis.
Mishina Y, Crombie R, Bradley A, Behringer RR
Dev Biol. 1999
PubMed ID: 10479450
Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.
Meno C, Gritsman K, Ohishi S, Ohfuji Y, Heckscher E, Mochida K, Shimono A, Kondoh H, Talbot WS, Robertson EJ, Schier AF, Hamada H
Mol Cell. 1999
PubMed ID: 10518210
The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice.
Song J, Oh SP, Schrewe H, Nomura M, Lei H, Okano M, Gridley T, Li E
Dev Biol. 1999
PubMed ID: 10452853
Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling.
Sasaki H, Nishizaki Y, Hui C, Nakafuku M, Kondoh H
Development. 1999
PubMed ID: 10433919
A vital role for glycosphingolipid synthesis during development and differentiation.
Yamashita T, Wada R, Sasaki T, Deng C, Bierfreund U, Sandhoff K, Proia RL
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10430909
Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis.
Blatt EN, Yan XH, Wuerffel MK, Hamilos DL, Brody SL
Am J Respir Cell Mol Biol. 1999
PubMed ID: 10423398
Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo.
Sun X, Meyers EN, Lewandoski M, Martin GR
Genes Dev. 1999
PubMed ID: 10421635
The role of the notochord for epaxial myotome formation in the mouse.
Dietrich S, Schubert FR, Gruss P, Lumsden A
Cell Mol Biol (Noisy-le-grand). 1999
PubMed ID: 10512192
Experimental analysis of the emergence of left-right asymmetry of the body axis in early postimplantation mouse embryos.
Tsang TE, Kinder SJ, Tam PP
Cell Mol Biol (Noisy-le-grand). 1999
PubMed ID: 10512182
Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis.
Davidson BP, Kinder SJ, Steiner K, Schoenwolf GC, Tam PP
Dev Biol. 1999
PubMed ID: 10373301
The SIL gene is required for mouse embryonic axial development and left-right specification.
Izraeli S, Lowe LA, Bertness VL, Good DJ, Dorward DW, Kirsch IR, Kuehn MR
Nature. 1999
PubMed ID: 10385121
Isolation of novel cDNAs by subtractions between the anterior mesendoderm of single mouse gastrula stage embryos.
Shimono A, Behringer RR
Dev Biol. 1999
PubMed ID: 10328927
Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.
Zaret K
Dev Biol. 1999
PubMed ID: 10208738
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling.
Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM, Rubenstein JL, Ericson J
Nature. 1999
PubMed ID: 10217145
Murine fibroblast growth factor receptor 1alpha isoforms mediate node regression and are essential for posterior mesoderm development.
Xu X, Li C, Takahashi K, Slavkin HC, Shum L, Deng CX
Dev Biol. 1999
PubMed ID: 10191046
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.
Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A
Development. 1999
PubMed ID: 10079226
Upstream region of rat serum albumin gene promoter contributes to promoter activity: presence of functional binding site for hepatocyte nuclear factor-3.
Hsiang CH, Marten NW, Straus DS
Biochem J. 1999
PubMed ID: 10024498
Functional equivalency between Otx2 and Otx1 in development of the rostral head.
Suda Y, Nakabayashi J, Matsuo I, Aizawa S
Development. 1999
PubMed ID: 9895322
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.
Nishina H, Vaz C, Billia P, Nghiem M, Sasaki T, De la Pompa JL, Furlonger K, Paige C, Hui C, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM
Development. 1999
PubMed ID: 9876179
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression.
Cui Y, Narayanan CS, Zhou J, Kumar A
Gene. 1998
PubMed ID: 9931457
The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives.
Tomihara-Newberger C, Haub O, Lee HG, Soares V, Manova K, Lacy E
Dev Biol. 1998
PubMed ID: 9851841
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.
Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB
Development. 1998
PubMed ID: 9811571
RNA helicase A is essential for normal gastrulation.
Lee CG, da Costa Soares V, Newberger C, Manova K, Lacy E, Hurwitz J
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9811865
Serum response factor is essential for mesoderm formation during mouse embryogenesis.
Arsenian S, Weinhold B, Oelgeschläger M, Rüther U, Nordheim A
EMBO J. 1998
PubMed ID: 9799237
Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice.
Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen WS, Lacy E, Bachvarova RF
Dev Dyn. 1998
PubMed ID: 9825865
Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo.
Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM
Nature. 1998
PubMed ID: 9790191
Sonic hedgehog is essential to foregut development.
Litingtung Y, Lei L, Westphal H, Chiang C
Nat Genet. 1998
PubMed ID: 9731532
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus.
Motoyama J, Liu J, Mo R, Ding Q, Post M, Hui CC
Nat Genet. 1998
PubMed ID: 9731531
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis.
Dufort D, Schwartz L, Harpal K, Rossant J
Development. 1998
PubMed ID: 9671576
Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system.
Matise MP, Epstein DJ, Park HL, Platt KA, Joyner AL
Development. 1998
PubMed ID: 9655799
Alteration of limb and brain patterning in early mouse embryos by ultrasound-guided injection of Shh-expressing cells.
Liu A, Joyner AL, Turnbull DH
Mech Dev. 1998
PubMed ID: 9739117
Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement.
Saga Y
Mech Dev. 1998
PubMed ID: 9739106
Genetic patterning of the posterior neuropore region of curly tail mouse embryos: deficiency of Wnt5a expression.
Gofflot F, Hall M, Morriss-Kay GM
Int J Dev Biol. 1998
PubMed ID: 9712518
Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice.
Ding Q, Motoyama J, Gasca S, Mo R, Sasaki H, Rossant J, Hui CC
Development. 1998
PubMed ID: 9636069
Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.
McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM, McMahon AP
Genes Dev. 1998
PubMed ID: 9585504
A role for SOX1 in neural determination.
Pevny LH, Sockanathan S, Placzek M, Lovell-Badge R
Development. 1998
PubMed ID: 9550729
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development.
Tang SJ, Hoodless PA, Lu Z, Breitman ML, McInnes RR, Wrana JL, Buchwald M
Development. 1998
PubMed ID: 9550720
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons.
Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ, De Mayo F, Burbach JP, Conneely OM
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9520484
Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1.
Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN
Nat Genet. 1998
PubMed ID: 9500550
Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6.
Chapman DL, Papaioannou VE
Nature. 1998
PubMed ID: 9490412
No turning, a mouse mutation causing left-right and axial patterning defects.
Melloy PG, Ewart JL, Cohen MF, Desmond ME, Kuehn MR, Lo CW
Dev Biol. 1998
PubMed ID: 9466889
Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects.
Aubin J, Lemieux M, Tremblay M, Bérard J, Jeannotte L
Dev Biol. 1997
PubMed ID: 9441679
Distribution pattern of HNF-3beta proteins in developing embryos of two mammalian species, the house shrew and the mouse.
Yasui K, Sasaki H, Arakaki R, Uemura M
Dev Growth Differ. 1997
PubMed ID: 9493826
The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives.
Peterson RS, Lim L, Ye H, Zhou H, Overdier DG, Costa RH
Mech Dev. 1997
PubMed ID: 9486531
Genetic patterning of the developing mouse tail at the time of posterior neuropore closure.
Gofflot F, Hall M, Morriss-Kay GM
Dev Dyn. 1997
PubMed ID: 9415428
Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula.
Belo JA, Bouwmeester T, Leyns L, Kertesz N, Gallo M, Follettie M, De Robertis EM
Mech Dev. 1997
PubMed ID: 9431803
Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos.
Goh KL, Yang JT, Hynes RO
Development. 1997
PubMed ID: 9334279
Altered neural cell fates and medulloblastoma in mouse patched mutants.
Goodrich LV, Milenković L, Higgins KM, Scott MP
Science. 1997
PubMed ID: 9262482
Differential induction of HNF-3 transcription factors during neuronal differentiation.
Jacob A, Budhiraja S, Reichel RR
Exp Cell Res. 1997
PubMed ID: 9260895
Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1.
Hynes M, Stone DM, Dowd M, Pitts-Meek S, Goddard A, Gurney A, Rosenthal A
Neuron. 1997
PubMed ID: 9247260
Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis.
Filosa S, Rivera-Pérez JA, Gómez AP, Gansmuller A, Sasaki H, Behringer RR, Ang SL
Development. 1997
PubMed ID: 9226455
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.
Lee J, Platt KA, Censullo P, Ruiz i Altaba A
Development. 1997
PubMed ID: 9216996
Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon.
Grindley JC, Hargett LK, Hill RE, Ross A, Hogan BL
Mech Dev. 1997
PubMed ID: 9232602
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Molkentin JD, Lin Q, Duncan SA, Olson EN
Genes Dev. 1997
PubMed ID: 9136933
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM
Genes Dev. 1997
PubMed ID: 9136932
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro.
Sasaki H, Hui C, Nakafuku M, Kondoh H
Development. 1997
PubMed ID: 9118802
Winged-helix, Hedgehog and Bmp genes are differentially expressed in distinct cell layers of the murine yolk sac.
Farrington SM, Belaoussoff M, Baron MH
Mech Dev. 1997
PubMed ID: 9152011
Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues.
Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA, Costa RH
Mol Cell Biol. 1997
PubMed ID: 9032290
Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4.
Mincheva A, Lichter P, Schütz G, Kaestner KH
Genomics. 1997
PubMed ID: 9119385
Nodal signaling and axis formation in the mouse.
Varlet I, Collignon J, Norris DP, Robertson EJ
Cold Spring Harb Symp Quant Biol. 1997
PubMed ID: 9598342
Patterns of gene expression in the neural plate and neural tube subdivide the embryonic forebrain into transverse and longitudinal domains.
Shimamura K, Martinez S, Puelles L, Rubenstein JL
Dev Neurosci. 1997
PubMed ID: 9078438
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system.
Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M
Cell. 1996
PubMed ID: 8978605
Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid.
Suzuki N, Labosky PA, Furuta Y, Hargett L, Dunn R, Fogo AB, Takahara K, Peters DM, Greenspan DS, Hogan BL
Development. 1996
PubMed ID: 8951074
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function.
Chiang C, Litingtung Y, Lee E, Young KE, Corden JL, Westphal H, Beachy PA
Nature. 1996
PubMed ID: 8837770
Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.
Zhou L, Lim L, Costa RH, Whitsett JA
J Histochem Cytochem. 1996
PubMed ID: 8813084
Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.
Epstein DJ, Marti E, Scott MP, McMahon AP
Development. 1996
PubMed ID: 8787761
Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice.
Tremblay P, Pituello F, Gruss P
Development. 1996
PubMed ID: 8756299
Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis.
Bellusci S, Henderson R, Winnier G, Oikawa T, Hogan BL
Development. 1996
PubMed ID: 8674409
Relationship between asymmetric nodal expression and the direction of embryonic turning.
Collignon J, Varlet I, Robertson EJ
Nature. 1996
PubMed ID: 8610012
Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation.
Pfaff SL, Mendelsohn M, Stewart CL, Edlund T, Jessell TM
Cell. 1996
PubMed ID: 8565076
A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain.
Ang SL, Jin O, Rhinn M, Daigle N, Stevenson L, Rossant J
Development. 1996
PubMed ID: 8565836
Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.
Mishina Y, Suzuki A, Ueno N, Behringer RR
Genes Dev. 1995
PubMed ID: 8543149
Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Winnier G, Blessing M, Labosky PA, Hogan BL
Genes Dev. 1995
PubMed ID: 7657163
Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo.
Martí E, Takada R, Bumcrot DA, Sasaki H, McMahon AP
Development. 1995
PubMed ID: 7671817
Requirement for Lim1 in head-organizer function.
Shawlot W, Behringer RR
Nature. 1995
PubMed ID: 7700351
The eed mutation disrupts anterior mesoderm production in mice.
Faust C, Schumacher A, Holdener B, Magnuson T
Development. 1995
PubMed ID: 7768172
Simultaneous visualization of Q-bands and FISH signals using a novel fluorochrome.
Kondoh Y, Ono T, Kagiyama N, Fujita S, Momiyama M, Hori SH, Yoshida MC
Cytogenet Cell Genet. 1995
PubMed ID: 7606937
fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.
Yamaguchi TP, Harpal K, Henkemeyer M, Rossant J
Genes Dev. 1994
PubMed ID: 8001822
Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter.
Clevidence DE, Overdier DG, Peterson RS, Porcella A, Ye H, Paulson KE, Costa RH
Dev Biol. 1994
PubMed ID: 7958446
Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord.
Günther T, Struwe M, Aguzzi A, Schughart K
Development. 1994
PubMed ID: 7720556
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.
Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JE
Genes Dev. 1994
PubMed ID: 7958910
Delayed activation of HNF-3 beta upon retinoic acid-induced teratocarcinoma cell differentiation.
Reichel RR, Budhiraja S, Jacob A
Exp Cell Res. 1994
PubMed ID: 7925656
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo.
Weinstein DC, Ruiz i Altaba A, Chen WS, Hoodless P, Prezioso VR, Jessell TM, Darnell JE
Cell. 1994
PubMed ID: 8069910
HNF-3 beta is essential for node and notochord formation in mouse development.
Ang SL, Rossant J
Cell. 1994
PubMed ID: 8069909
The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.
Kaestner KH, Hiemisch H, Luckow B, Schütz G
Genomics. 1994
PubMed ID: 8034310
HNF-3 beta as a regulator of floor plate development.
Sasaki H, Hogan BL
Cell. 1994
PubMed ID: 8287471
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.
Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP
Cell. 1993
PubMed ID: 7916661
The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins.
Ang SL, Wierda A, Wong D, Stevens KA, Cascio S, Rossant J, Zaret KS
Development. 1993
PubMed ID: 8306889
Hepatocyte nuclear factor 3/fork head or "winged helix" proteins: a family of transcription factors of diverse biologic function.
Lai E, Clark KL, Burley SK, Darnell JE
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8248124
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm.
Monaghan AP, Kaestner KH, Grau E, Schütz G
Development. 1993
PubMed ID: 8187630
Six members of the mouse forkhead gene family are developmentally regulated.
Kaestner KH, Lee KH, Schlöndorff J, Hiemisch H, Monaghan AP, Schütz G
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7689224
Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
Sasaki H, Hogan BL
Development. 1993
PubMed ID: 8375339
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles.
Cereghini S, Ott MO, Power S, Maury M
Development. 1992
PubMed ID: 1363228
Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4.
Avraham KB, Prezioso VR, Chen WS, Lai E, Sladek FM, Zhong W, Darnell JE, Jenkins NA, Copeland NG
Genomics. 1992
PubMed ID: 1612587
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head.
Lai E, Prezioso VR, Tao WF, Chen WS, Darnell JE
Genes Dev. 1991
PubMed ID: 1672118
Low levels of eosinophil cationic proteins in patients with asthma.
Venge P, Zetterström O, Dahl R, Roxin LE, Olsson I
Lancet. 1977
PubMed ID: 70587

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3170	15376	25099
EnsEMBL Gene(s)	ENSG00000125798	ENSMUSG00000037025	ENSRNOG00000013133
Unigene	Hs.155651	Mm.938	Rn.10948
Homologene	FOXA2	Foxa2	Foxa2
OMIM	600288	N/A	N/A
GeneCards	FOXA2	N/A	N/A
Beta Cell Genomics	DT.100743798 DT.423625	DT.488237 DT.99846201	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	3170	15376	25099

External resources from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
FOXA2	PPARGC1B	BioGRID	empirical	16459311
FOXA2	GSC	HPRD, BioGRID	empirical	12642491
FOXA2	EN2	HPRD, BioGRID	empirical	12642491
FOXA2	EP300	IntAct	empirical	20609350
FOXA2	HIF1A	IntAct	empirical	20609350
FOXA2	ONECUT1	HPRD, BioGRID	empirical	12509444
FOXA2	HOXA5	HPRD, BioGRID	empirical	12642491 12163409
FOXA2	LHX1	BioGRID	empirical	12642491
FOXA2	ARNT	IntAct	empirical	20609350
FOXA2	MIP	HPRD	empirical	12642491
FOXA2	OTX2	HPRD, BioGRID	empirical	10623575 12642491
FOXA2	C1QBP	Sanger Interaction Map	predicted	15345047
FOXA2	TLE1	HPRD, BioGRID	empirical	10748198
FOXA2	NCOA1	HPRD, BioGRID	empirical	11069927