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HLA-H

Gene Description:   major histocompatibility complex, class I, H (pseudogene) Synonyms:   HLAHP, HLA-H Orthologs:   Human HLA-H (pseudo)   Sources Sources Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

(Human) GRCh37 - chr6:29855383..29858856 (3.47 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas no data no data no data no data no data no data no data no data no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Interactions Table for HLA-H: The HLA-H interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HLA-H   SQSTM1   IntAct  empirical  20562859

View all

KEGG Network: None available   None available.

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 7   Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Antigen processing and presentation GO:0019882 MHC class I receptor activity GO:0032393 MHC class I protein complex GO:0042612

	KEGG Network: None available
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 7 Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Antigen processing and presentation GO:0019882 MHC class I receptor activity GO:0032393 MHC class I protein complex GO:0042612

Publications: 9

• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation]
  Shiobara S, Sato H, Furukawa T, Tsukada J, Yasue S, Takeda H, Togawa A, Taira M, Sakai Y, Aizawa Y, Nakao S
  Rinsho Ketsueki. 2004
  PubMed ID: 15359910
   
  
• Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation.
  Kotzampasaki EM, Spyropoulou-Vlachou MS, Kalofoutis C, Vrani V, Kalofoutis A, Stavropoulos-Giokas C
  Transplant Proc. 2004
  PubMed ID: 15350465
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
  Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci.
  Grimsley C, Mather KA, Ober C
  Mol Biol Evol. 1998
  PubMed ID: 9866194
   
  
• Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes.
  Geraghty DE, Koller BH, Pei J, Hansen JA
  J Immunol. 1992
  PubMed ID: 1517564
   
  
• HLA-AR, an inactivated antigen-presenting locus related to HLA-A. Implications for the evolution of the MHC.
  Zemmour J, Koller BH, Ennis PD, Geraghty DE, Lawlor DA, Orr HT, Parham P
  J Immunol. 1990
  PubMed ID: 2329283
   
  
• Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene.
  Chorney MJ, Sawada I, Gillespie GA, Srivastava R, Pan J, Weissman SM
  Mol Cell Biol. 1990
  PubMed ID: 2294403
   
  
• Exon/intron organization and complete nucleotide sequence of an HLA gene.
  Malissen M, Malissen B, Jordan BR
  Proc Natl Acad Sci U S A. 1982
  PubMed ID: 6461010
   
  

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