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HLA-E

Gene Description:   RT1 class Ib, locus S3; RIKEN cDNA C920025E04 gene; major histocompatibility complex, class I, E Synonyms:   EA2.1, RTBM1, MHC, HLA-6.2, HLA-E, C920025E04Rik, QA1, DKFZp686P19218, H2-T23, EA1.2, RT1-S3, RT1-BM1, RT-BM1, MGC102517 Orthologs:   Human HLA-E (protein-coding), Mouse C920025E04Rik (protein-coding), Rat RT1-S3 (protein-coding)   Sources Sources Human-Mouse: MGD, RGD Human-Rat: MGD, RGD Mouse-Rat: MGD, RGD Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd24	Mouse	chr17:35340111..41438922	6.10	184

(Human) GRCh37 - chr6:30457183..30461982 (4.80 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:36166718..36248615 (81.90 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr20:2815943..2820644 (4.70 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas           no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HLA-E: The HLA-E interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HLA-E   PDIA3   Reactome  predicted    HLA-E   HLA-E   HPRD  empirical  9605335  HLA-E   KLRC1   HPRD  empirical  9486650  HLA-E   KLRC2   HPRD  empirical  9486650  9103421  HLA-E   KLRD1   HPRD, BioGRID  empirical  14734748  9815261  9486650  9886400  HLA-E   B2M   HPRD, BioGRID, Reactome  empirical  9605335  10064069  HLA-E   PPP1R16A   HPRD, IntAct  empirical  16169070  HLA-E   CD8A   HPRD  empirical  10809759

View all

KEGG Network: 10   Allograft rejection Human - 5330 Rat - 5330 Antigen processing and presentation Human - 4612 Rat - 4612 Autoimmune thyroid disease Human - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Rat - 4514 Endocytosis Human - 4144 Rat - 4144 Graft-versus-host disease Human - 5332 Rat - 5332 Natural killer cell mediated cytotoxicity Human - 4650 Rat - 4650 Phagosome Human - 4145 Rat - 4145 Type I diabetes mellitus Human - 4940 Rat - 4940 Viral myocarditis Human - 5416 Rat - 5416

Biocarta: None available   None available.

Reactome: 1   Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell REACT_11152

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 15   Golgi membrane GO:0000139 Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Plasma membrane GO:0005886 Immune response GO:0006955 ER to Golgi transport vesicle membrane GO:0012507 Membrane GO:0016020 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 Antigen processing and presentation GO:0019882 MHC class I receptor activity GO:0032393 MHC class I protein complex GO:0042612 Regulation of immune response GO:0050776 Interferon-gamma-mediated signaling pathway GO:0060333 Type I interferon-mediated signaling pathway GO:0060337 Integral to lumenal side of endoplasmic reticulum membrane GO:0071556

	KEGG Network: 10 Allograft rejection Human - 5330 Rat - 5330 Antigen processing and presentation Human - 4612 Rat - 4612 Autoimmune thyroid disease Human - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Rat - 4514 Endocytosis Human - 4144 Rat - 4144 Graft-versus-host disease Human - 5332 Rat - 5332 Natural killer cell mediated cytotoxicity Human - 4650 Rat - 4650 Phagosome Human - 4145 Rat - 4145 Type I diabetes mellitus Human - 4940 Rat - 4940 Viral myocarditis Human - 5416 Rat - 5416
	Biocarta: None available
	Reactome: 1 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell REACT_11152
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 15 Golgi membrane GO:0000139 Antigen processing and presentation of peptide antigen via MHC class I GO:0002474 Plasma membrane GO:0005886 Immune response GO:0006955 ER to Golgi transport vesicle membrane GO:0012507 Membrane GO:0016020 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 Antigen processing and presentation GO:0019882 MHC class I receptor activity GO:0032393 MHC class I protein complex GO:0042612 Regulation of immune response GO:0050776 Interferon-gamma-mediated signaling pathway GO:0060333 Type I interferon-mediated signaling pathway GO:0060337 Integral to lumenal side of endoplasmic reticulum membrane GO:0071556

Type 1 Diabetes Publications: 3

• HLA-E-restricted regulatory CD8(+) T cells are involved in development and control of human autoimmune type 1 diabetes.
  Jiang H, Canfield SM, Gallagher MP, Jiang HH, Jiang Y, Zheng Z, Chess L
  J Clin Invest. 2010
  PubMed ID: 20877010
   
  
• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
  Wellcome Trust Case Control Consortium
  Nature. 2007
  PubMed ID: 17554300
   
  

Publications: 183

• HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.
  Okada Y, Yamazaki K, Umeno J, Takahashi A, Kumasaka N, Ashikawa K, Aoi T, Takazoe M, Matsui T, Hirano A, Matsumoto T, Kamatani N, Nakamura Y, Yamamoto K, Kubo M
  Gastroenterology. 2011
  PubMed ID: 21699788
   
  
• Association between HLA-E *0101 homozygosity and recurrent miscarriage in Egyptian women.
  Mosaad YM, Abdel-Dayem Y, El-Deek BS, El-Sherbini SM
  Scand J Immunol. 2011
  PubMed ID: 21410502
   
  
• Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians.
  Hassen E, Ghedira R, Ghandri N, Farhat K, Gabbouj S, Bouaouina N, Abdelaziz H, Nouri A, Chouchane L
  DNA Cell Biol. 2011
  PubMed ID: 21332388
   
  
• Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
  Okada Y, Hirota T, Kamatani Y, Takahashi A, Ohmiya H, Kumasaka N, Higasa K, Yamaguchi-Kabata Y, Hosono N, Nalls MA, Chen MH, van Rooij FJ, Smith AV, Tanaka T, Couper DJ, Zakai NA, Ferrucci L, Longo DL, Hernandez DG, Witteman JC, Harris TB, O'Donnell CJ, Ganesh SK, Matsuda K, Tsunoda T, Tanaka T, Kubo M, Nakamura Y, Tamari M, Yamamoto K, Kamatani N
  PLoS Genet. 2011
  PubMed ID: 21738478
   
  
• Expression of immune-modulatory molecules HLA-G and HLA-E by tumor cells in glioblastomas: an unexpected prognostic significance?
  Kren L, Slaby O, Muckova K, Lzicarova E, Sova M, Vybihal V, Svoboda T, Fadrus P, Lakomy R, Vanhara P, Krenova Z, Sterba J, Smrcka M, Michalek J
  Neuropathology. 2011
  PubMed ID: 20667016
   
  
• Linkage disequilibrium between HLA-G*0104 and HLA-E*0103 alleles in Tswa Pygmies.
  Di Cristofaro J, Julie DC, Buhler S, Frassati C, Basire A, Galicher V, Baier C, Essautier A, Regnier A, Granier T, Lepfoundzou AD, Chiaroni J, Picard C
  Tissue Antigens. 2011
  PubMed ID: 21299523
   
  
• Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population.
  Zheng HF, Zuo XB, Lu WS, Li Y, Cheng H, Zhu KJ, Yin XY, Zhang C, Ren YQ, Wang WJ, Sun LD, Cui Y, Yang S, Zhang FY, Zhang XJ
  J Dermatol Sci. 2011
  PubMed ID: 21208785
   
  
• Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma.
  Chen A, Shen Y, Xia M, Xu L, Pan N, Yin Y, Miao F, Shen C, Xie W, Zhang J
  Neoplasma. 2011
  PubMed ID: 21744989
   
  
• Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
  Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS, Shin SY, Heneghan MA, Neuberger JM, Donaldson PT, Day DB, Ducker SJ, Muriithi AW, Wheater EF, Hammond CJ, Dawwas MF, UK PBC Consortium, Wellcome Trust Case Control Consortium 3, Jones DE, Peltonen L, Alexander GJ, Sandford RN, Anderson CA
  Nat Genet. 2011
  PubMed ID: 21399635
   
  
• Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
  Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH
  PLoS One. 2011
  PubMed ID: 21386911
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients.
  de Kruijf EM, Sajet A, van Nes JG, Natanov R, Putter H, Smit VT, Liefers GJ, van den Elsen PJ, van de Velde CJ, Kuppen PJ
  J Immunol. 2010
  PubMed ID: 21057081
   
  
• A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
  Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20673868
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• Up-regulation of MHC class I and class II in the skeletal muscles of myasthenia gravis.
  Iwasa K, Kato-Motozaki Y, Furukawa Y, Maruta T, Ishida C, Yoshikawa H, Yamada M
  J Neuroimmunol. 2010
  PubMed ID: 20546939
   
  
• Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
  Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
  Am J Obstet Gynecol. 2010
  PubMed ID: 20452482
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?
  Kren L, Muckova K, Lzicarova E, Sova M, Vybihal V, Svoboda T, Fadrus P, Smrcka M, Slaby O, Lakomy R, Vanhara P, Krenova Z, Michalek J
  J Neuroimmunol. 2010
  PubMed ID: 20167379
   
  
• Common genetic variation and performance on standardized cognitive tests.
  Cirulli ET, Kasperavičiūtė D, Attix DK, Need AC, Ge D, Gibson G, Goldstein DB
  Eur J Hum Genet. 2010
  PubMed ID: 20125193
   
  
• Cell bio-imaging reveals co-expression of HLA-G and HLA-E in human preimplantation embryos.
  Shaikly V, Shakhawat A, Withey A, Morrison I, Taranissi M, Dealtry GB, Jabeen A, Cherry R, Fernández N
  Reprod Biomed Online. 2010
  PubMed ID: 20113960
   
  
• Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
  Australo-Anglo-American Spondyloarthritis Consortium (TASC), Reveille JD, Sims AM, Danoy P, Evans DM, Leo P, Pointon JJ, Jin R, Zhou X, Bradbury LA, Appleton LH, Davis JC, Diekman L, Doan T, Dowling A, Duan R, Duncan EL, Farrar C, Hadler J, Harvey D, Karaderi T, Mogg R, Pomeroy E, Pryce K, Taylor J, Savage L, Deloukas P, Kumanduri V, Peltonen L, Ring SM, Whittaker P, Glazov E, Thomas GP, Maksymowych WP, Inman RD, Ward MM, Stone MA, Weisman MH, Wordsworth BP, Brown MA
  Nat Genet. 2010
  PubMed ID: 20062062
   
  
• Irradiation-induced up-regulation of HLA-E on macrovascular endothelial cells confers protection against killing by activated natural killer cells.
  Riederer I, Sievert W, Eissner G, Molls M, Multhoff G
  PLoS One. 2010
  PubMed ID: 21179573
   
  
• Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
  UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, Wesley E, Parnell K, Zhang H, Drummond H, Nimmo ER, Massey D, Blaszczyk K, Elliott T, Cotterill L, Dallal H, Lobo AJ, Mowat C, Sanderson JD, Jewell DP, Newman WG, Edwards C, Ahmad T, Mansfield JC, Satsangi J, Parkes M, Mathew CG, Wellcome Trust Case Control Consortium 2, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Samani N, Trembath RC, Viswanathan AC, Wood N, Spencer CC, Barrett JC, Bellenguez C, Davison D, Freeman C, Strange A, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Deloukas P, Peltonen L, Mathew CG, Blackwell JM, Brown MA, Corvin A, McCarthy MI, Spencer CC, Attwood AP, Stephens J, Sambrook J, Ouwehand WH, McArdle WL, Ring SM, Strachan DP
  Nat Genet. 2009
  PubMed ID: 19915572
   
  
• Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors.
  Ludajic K, Rosenmayr A, Faé I, Fischer GF, Balavarca Y, Bickeböller H, Kalhs P, Greinix HT
  Transplantation. 2009
  PubMed ID: 19935378
   
  
• The HLA-E(R)/HLA-E(R) genotype affects the natural course of hepatitis C virus (HCV) infection and is associated with HLA-E-restricted recognition of an HCV-derived peptide by interferon-gamma-secreting human CD8(+) T cells.
  Schulte D, Vogel M, Langhans B, Krämer B, Körner C, Nischalke HD, Steinberg V, Michalk M, Berg T, Rockstroh JK, Sauerbruch T, Spengler U, Nattermann J
  J Infect Dis. 2009
  PubMed ID: 19780673
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• Clinical significance of HLA-E*0103 homozygosity on survival after allogeneic hematopoietic stem-cell transplantation.
  Danzer M, Polin H, Pröll J, Haunschmid R, Hofer K, Stabentheiner S, Hackl C, Kasparu H, König J, Hauser H, Binder M, Weiss R, Gabriel C, Krieger O
  Transplantation. 2009
  PubMed ID: 19696636
   
  
• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
  International Schizophrenia Consortium, Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF, Sklar P
  Nature. 2009
  PubMed ID: 19571811
   
  
• Common variants conferring risk of schizophrenia.
  Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, Genetic Risk and Outcome in Psychosis (GROUP), Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA
  Nature. 2009
  PubMed ID: 19571808
   
  
• Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
  Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD
  Nat Biotechnol. 2009
  PubMed ID: 19349973
   
  
• Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells.
  Levy EM, Sycz G, Arriaga JM, Barrio MM, von Euw EM, Morales SB, González M, Mordoh J, Bianchini M
  Innate Immun. 2009
  PubMed ID: 19318419
   
  
• Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line.
  Huang Z, Hyodo H, Fujii T, Nagamatsu T, Matsumoto J, Kawana K, Yamashita T, Yasugi T, Kozuma S, Taketani Y
  Am J Reprod Immunol. 2009
  PubMed ID: 19239424
   
  
• Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
  Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Hui J, Beilby J, Warrington NM, James A, Palmer LJ, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatley A, Altmuller J, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Gislason D, Park CS, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson UB, Ng MC, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJ, van Rij AM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Boner A, Pescollderungg L, Girelli D, Olivieri O, Martinelli N, Ludviksson BR, Ludviksdottir D, Eyjolfsson GI, Arnar D, Thorgeirsson G, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K
  Nat Genet. 2009
  PubMed ID: 19198610
   
  
• HLA-E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms.
  Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Lin JG, Hsueh KC, Huang YM, Chang JS, Tsai FJ
  Arthritis Rheum. 2009
  PubMed ID: 19180512
   
  
• Pregnancy-specific {beta}-1-glycoprotein 1 and human leukocyte antigen-E mRNA in human sperm: differential expression in fertile and infertile men and evidence of a possible functional role during early development.
  Avendaño C, Franchi A, Jones E, Oehninger S
  Hum Reprod. 2009
  PubMed ID: 18987160
   
  
• HLA-E gene polymorphism associates with ankylosing spondylitis in Sardinia.
  Paladini F, Belfiore F, Cocco E, Carcassi C, Cauli A, Vacca A, Fiorillo MT, Mathieu A, Cascino I, Sorrentino R
  Arthritis Res Ther. 2009
  PubMed ID: 19912639
   
  
• HLA-E and HLA-E-bound peptides: recognition by subsets of NK and T cells.
  Pietra G, Romagnani C, Moretta L, Mingari MC
  Curr Pharm Des. 2009
  PubMed ID: 19860683
   
  
• HPLC and MS analysis for the identification and characterisation of peptides presented in the context of the non-classical human leukocytes antigen (HLA) class I molecule HLA-E.
  Millo E, Damonte G
  Curr Pharm Des. 2009
  PubMed ID: 19860682
   
  
• The phagosomal proteome in interferon-gamma-activated macrophages.
  Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P
  Immunity. 2009
  PubMed ID: 19144319
   
  
• Ethnic variability in human leukocyte antigen-E haplotypes.
  Antoun A, Jobson S, Cook M, Moss P, Briggs D
  Tissue Antigens. 2009
  PubMed ID: 19140831
   
  
• [The expression of human leukocyte antigen G and E on human first trimester placenta and its relationship with recurrent spontaneous abortion]
  Peng B, Zhang L, Xing AY, Hu M, Liu SY
  Sichuan Da Xue Xue Bao Yi Xue Ban. 2008
  PubMed ID: 19253840
   
  
• Classical and non-classical HLA molecules and p16(INK4a) expression in precursors lesions and invasive cervical cancer.
  Gonçalves MA, Le Discorde M, Simões RT, Rabreau M, Soares EG, Donadi EA, Carosella ED
  Eur J Obstet Gynecol Reprod Biol. 2008
  PubMed ID: 18692948
   
  
• HLA-E: strong association with beta2-microglobulin and surface expression in the absence of HLA class I signal sequence-derived peptides.
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• Multiple genetic loci for bone mineral density and fractures.
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• Structural basis for NKG2A/CD94 recognition of HLA-E.
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• Identification of amino acid positions involved in HLA-E expression.
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• GUDMAP: the genitourinary developmental molecular anatomy project.
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• CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
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• Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer.
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• Influence of Hsp70 and HLA-E on the killing of leukemic blasts by cytokine/Hsp70 peptide-activated human natural killer (NK) cells.
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• The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.
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• Immune-refractory cancers and their little helpers--an extended role for immunetolerogenic MHC molecules HLA-G and HLA-E?
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• HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia.
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• Association of CD94/NKG2A, CD94/NKG2C, and its ligand HLA-E polymorphisms with Behcet's disease.
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• [Relationship of human leucocyte antigen G, E with intrahepatic cholestasis of pregnancy]
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• HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease.
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• HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.
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• Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1.
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  Cell. 2005
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  Science. 2005
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• Cutting edge: HLA-E binds a peptide derived from the ATP-binding cassette transporter multidrug resistance-associated protein 7 and inhibits NK cell-mediated lysis.
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• Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation.
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• An HLA-E single chain trimer inhibits human NK cell reactivity towards porcine cells.
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• The HLA-A2 restricted T cell epitope HCV core 35-44 stabilizes HLA-E expression and inhibits cytolysis mediated by natural killer cells.
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• HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.
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• Nef: "necessary and enforcing factor" in HIV infection.
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• HLA-E surface expression is independent of the availability of HLA class I signal sequence-derived peptides in human tumor cell lines.
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• [Analysis on HLA-E polymorphism in Guangdong Han population]
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• HLA-E polymorphism in patients with nasopharyngeal carcinoma.
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  Tissue Antigens. 2004
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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
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  Genome Res. 2004
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• HLA-C and HLA-E reduce antibody-dependent natural killer cell-mediated cytotoxicity of HIV-infected primary T cell blasts.
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  AIDS. 2004
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• A GATA factor mediates cell type-restricted induction of HLA-E gene transcription by gamma interferon.
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• HIV accessory proteins and surviving the host cell.
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• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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  Nature. 2004
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• Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm.
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• The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes.
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• The cationic region from HIV tat enhances the cell-surface expression of epitope/MHC class I complexes.
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• The DNA sequence and analysis of human chromosome 6.
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• Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal-placental immune recognition.
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• HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.
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• Characterization of monoclonal antibodies recognizing HLA-G or HLA-E: new tools to analyze the expression of nonclassical HLA class I molecules.
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• HLA-E allelic variants. Correlating differential expression, peptide affinities, crystal structures, and thermal stabilities.
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• Analysis of HLA-E expression in human tumors.
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• [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]
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