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HLA-DRB5

Gene Description:   major histocompatibility complex, class II, DR beta 5 Synonyms:   HLA-DRB5, HLA-DRB, FLJ76359 Orthologs:   Human HLA-DRB5 (protein-coding)   Sources Sources Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

(Human) GRCh37 - chr6:32485120..32557562 (72.44 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas           no data no data no data no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HLA-DRB5: The HLA-DRB5 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HLA-DRB5   CTAG1B   HPRD  empirical  11782380  HLA-DRB5   HLA-DRA   HPRD, Reactome  empirical  12244309

View all

KEGG Network: 18   Allograft rejection Human - 5330 Antigen processing and presentation Human - 4612 Asthma Human - 5310 Autoimmune thyroid disease Human - 5320 Cell adhesion molecules (CAMs) Human - 4514 Graft-versus-host disease Human - 5332 Hematopoietic cell lineage Human - 4640 Influenza A Human - 5164 Intestinal immune network for IgA production Human - 4672 Leishmaniasis Human - 5140 Phagosome Human - 4145 Rheumatoid arthritis Human - 5323 Staphylococcus aureus infection Human - 5150 Systemic lupus erythematosus Human - 5322 Toxoplasmosis Human - 5145 Tuberculosis Human - 5152 Type I diabetes mellitus Human - 4940 Viral myocarditis Human - 5416

Biocarta: None available   None available.

Reactome: None available   None available.

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 15   Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Immune response GO:0006955 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 Late endosome membrane GO:0031902 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

	KEGG Network: 18 Allograft rejection Human - 5330 Antigen processing and presentation Human - 4612 Asthma Human - 5310 Autoimmune thyroid disease Human - 5320 Cell adhesion molecules (CAMs) Human - 4514 Graft-versus-host disease Human - 5332 Hematopoietic cell lineage Human - 4640 Influenza A Human - 5164 Intestinal immune network for IgA production Human - 4672 Leishmaniasis Human - 5140 Phagosome Human - 4145 Rheumatoid arthritis Human - 5323 Staphylococcus aureus infection Human - 5150 Systemic lupus erythematosus Human - 5322 Toxoplasmosis Human - 5145 Tuberculosis Human - 5152 Type I diabetes mellitus Human - 4940 Viral myocarditis Human - 5416
	Biocarta: None available
	Reactome: None available
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 15 Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Immune response GO:0006955 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 Late endosome membrane GO:0031902 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

Type 1 Diabetes Publications: 4

• Immunogenetic susceptibility to diabetes mellitus in patients with liver disease.
  Montano-Loza AJ, Sultan A, Falanga D, Loss G, Mason AL
  Liver Int. 2009
  PubMed ID: 19663932
   
  
• HLA polymorphism in type 1 diabetes Tunisians.
  Abid Kamoun H, Hmida S, Kaabi H, Abid A, Slimane Houissa H, Maamar M, Mojaat N, Ben Hamed L, Dridi A, Kamoun Zribi M, Nagati K, Haddad A, Boukef K
  Ann Genet. 2002
  PubMed ID: 11934390
   
  
• Comparison of DR beta 1 alleles from diabetic and normal individuals.
  Freeman SM, Saunders TL, Madden M, Segall M, Bach FH, Wu SK
  Hum Immunol. 1987
  PubMed ID: 2884201
   
  
• Characterization of three HLA-DR beta genes isolated from an HLA-DR 3/4 insulin-dependent diabetic patient.
  Owerbach D, Rich C, Taneja K
  Immunogenetics. 1986
  PubMed ID: 3015788
   
  

Publications: 170

• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
  Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD
  Nat Genet. 2011
  PubMed ID: 21297633
   
  
• Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.
  Slager SL, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Rassenti LZ, Leis JF, Camp NJ, Glenn M, Kay NE, Cunningham JM, Hanson CA, Marti GE, Weinberg JB, Morrison VA, Link BK, Call TG, Caporaso NE, Cerhan JR
  Blood. 2011
  PubMed ID: 21131588
   
  
• Bimodal distribution of RNA expression levels in human skeletal muscle tissue.
  Mason CC, Hanson RL, Ossowski V, Bian L, Baier LJ, Krakoff J, Bogardus C
  BMC Genomics. 2011
  PubMed ID: 21299892
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.
  Singer JB, Lewitzky S, Leroy E, Yang F, Zhao X, Klickstein L, Wright TM, Meyer J, Paulding CA
  Nat Genet. 2010
  PubMed ID: 20639878
   
  
• No evidence for an effect of DNA methylation on multiple sclerosis severity at HLA-DRB1*15 or HLA-DRB5.
  Handel AE, De Luca GC, Morahan J, Handunnetthi L, Sadovnick AD, Ebers GC, Ramagopalan SV
  J Neuroimmunol. 2010
  PubMed ID: 20394989
   
  
• The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses.
  Christiansen OB, Steffensen R, Nielsen HS
  J Reprod Immunol. 2010
  PubMed ID: 20307907
   
  
• Visual hallucinations and HLA class II antigens in cortical dementia.
  Gómez-Tortosa E, Aguerri M, Sainz MJ, Losada M, García-Ruiz PJ, Cárdaba B
  Dement Geriatr Cogn Disord. 2010
  PubMed ID: 20606439
   
  
• [Association of hemorrhagic fever with renal syndrome and HLA-DRB allele polymorphisms in Han nationality, Hubei province.]
  Wei B, Zhu YQ, Hou W, Yang ZQ, Sun L, Luo F, Tang XY
  Zhonghua Liu Xing Bing Xue Za Zhi. 2009
  PubMed ID: 20193583
   
  
• [A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang]
  Liao PH, Qin JM, Zeng TX, Li F, Cai JF, He L
  Zhonghua Liu Xing Bing Xue Za Zhi. 2009
  PubMed ID: 20193235
   
  
• CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
  Beswick EJ, Reyes VE
  World J Gastroenterol. 2009
  PubMed ID: 19533806
   
  
• Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility.
  Lincoln MR, Ramagopalan SV, Chao MJ, Herrera BM, Deluca GC, Orton SM, Dyment DA, Sadovnick AD, Ebers GC
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19380721
   
  
• Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy.
  Nielsen HS, Steffensen R, Varming K, Van Halteren AG, Spierings E, Ryder LP, Goulmy E, Christiansen OB
  Hum Mol Genet. 2009
  PubMed ID: 19223392
   
  
• HLA risk markers for chronic myelogenous leukemia in Eastern Canada.
  Naugler C, Liwski R
  Leuk Lymphoma. 2009
  PubMed ID: 19235017
   
  
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
  Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
  J Proteome Res. 2009
  PubMed ID: 19159218
   
  
• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
  Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH
  Nat Genet. 2009
  PubMed ID: 19122664
   
  
• HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes.
  Zepeda-Gomez S, Montaño-Loza A, Zapata-Colindres JC, Paz F, Olivera-Martinez M, López-Reyes A, Granados J, Vargas-Alarcón G
  Immunol Invest. 2009
  PubMed ID: 19811438
   
  
• Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.
  Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG
  Arthritis Rheum. 2009
  PubMed ID: 19116923
   
  
• MHC class II transport at a glance.
  Berger AC, Roche PA
  J Cell Sci. 2009
  PubMed ID: 19092054
   
  
• Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.
  Caillier SJ, Briggs F, Cree BA, Baranzini SE, Fernandez-Viña M, Ramsay PP, Khan O, Royal W, Hauser SL, Barcellos LF, Oksenberg JR
  J Immunol. 2008
  PubMed ID: 18832704
   
  
• Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice.
  Kawamura K, McLaughlin KA, Weissert R, Forsthuber TG
  J Immunol. 2008
  PubMed ID: 18713991
   
  
• Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort.
  Lacap PA, Huntington JD, Luo M, Nagelkerke NJ, Bielawny T, Kimani J, Wachihi C, Ngugi EN, Plummer FA
  AIDS. 2008
  PubMed ID: 18520346
   
  
• [Human leukocyte antigen genes to genetic predisposition in diffuse panbonchiolitis]
  Shen C, She J
  Zhonghua Jie He He Hu Xi Za Zhi. 2008
  PubMed ID: 18846964
   
  
• MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.
  De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E
  Proc Natl Acad Sci U S A. 2008
  PubMed ID: 18305173
   
  
• MHC class II molecules on the move for successful antigen presentation.
  Rocha N, Neefjes J
  EMBO J. 2008
  PubMed ID: 18046453
   
  
• Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations.
  Sebastiani GD, Morozzi G, Bellisai F, Fineschi I, Bacarelli MR, Simpatico A, Font J, Cervera R, Houssiau F, Fernandez-Nebro A, De Ramon Garrido E, De Pità O, Smolen J, Galeazzi M, ECAISLE
  Immunol Invest. 2008
  PubMed ID: 18569076
   
  
• Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
  Qi Q, August A
  Sci STKE. 2007
  PubMed ID: 17652306
   
  
• HLA class II amino acid epitopes as susceptibility markers of sarcoidosis.
  Voorter CE, Amicosante M, Berretta F, Groeneveld L, Drent M, van den Berg-Loonen EM
  Tissue Antigens. 2007
  PubMed ID: 17559577
   
  
• Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus.
  Christian N, Smikle MF, DeCeulaer K, Daniels L, Walravens MJ, Barton EN
  West Indian Med J. 2007
  PubMed ID: 17910142
   
  
• hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
  Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
  Genomics. 2007
  PubMed ID: 17207965
   
  
• Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort.
  Li S, Jiao H, Yu X, Strong AJ, Shao Y, Sun Y, Altfeld M, Lu Y
  J Acquir Immune Defic Syndr. 2007
  PubMed ID: 17106278
   
  
• Autophagy in MHC class II presentation: sampling from within.
  Menéndez-Benito V, Neefjes J
  Immunity. 2007
  PubMed ID: 17241953
   
  
• Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors.
  Saad AH, Ghor MA, Osman A, Sherbiny MA, Zakaria Z
  J Egypt Soc Parasitol. 2006
  PubMed ID: 17153701
   
  
• HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population.
  Tromp G, Ogata T, Gregoire L, Goddard KA, Skunca M, Lancaster WD, Parrado AR, Lu Q, Shibamura H, Sakalihasan N, Limet R, Mackean GL, Arthur C, Sueda T, Kuivaniemi H
  Ann N Y Acad Sci. 2006
  PubMed ID: 17182961
   
  
• Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.
  Finzi A, Brunet A, Xiao Y, Thibodeau J, Cohen EA
  J Virol. 2006
  PubMed ID: 16973583
   
  
• Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa.
  Lombard Z, Dalton DL, Venter PA, Williams RC, Bornman L
  Hum Immunol. 2006
  PubMed ID: 16916662
   
  
• Identification of a new allele, HLA-DRB5*0113, through three different molecular biology techniques.
  Garino E, Berrino M, Bertinetto F, Caropreso P, Chidichimo R, Dametto E, Fasano ME, Frisaldi E, Mazzola G, Tondat F, Boccadoro M, Bruno B, Amoroso A
  Tissue Antigens. 2006
  PubMed ID: 16671952
   
  
• Identification of a novel HLA-DRB1*09 allele, DRB1*0904, in the Korean population, by sequence-based typing.
  Song CH, Baek JY, Heo YS, Kwack K, Kwon OJ
  Tissue Antigens. 2006
  PubMed ID: 16441501
   
  
• The role of HLA molecules in susceptibility to chronic rheumatic heart disease.
  Kudat H, Telci G, Sozen AB, Oguz F, Akkaya V, Ozcan M, Atilgan D, Carin M, Guven O
  Int J Immunogenet. 2006
  PubMed ID: 16426242
   
  
• Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks.
  Miranda SM, Porto LC, Pontes LF, Filgueira AL
  J Eur Acad Dermatol Venereol. 2006
  PubMed ID: 16405603
   
  
• [Microarray DNA chip in analyzing the association between HLA-DRB and advanced hepatosplenic schistosomiasis]
  Cheng YL, Xu MX, Song WJ, Yang Y, Liu WQ, Li YL, Qiu MY, Wu H
  Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing. 2005
  PubMed ID: 16566202
   
  
• Description of a new HLA-DRB1*1104, DRB1*110403.
  Longhi E, Frison S, Andreini E, Favoino B, Poli F, Scalamogna M
  Tissue Antigens. 2005
  PubMed ID: 16305688
   
  
• Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
  Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA
  EMBO J. 2005
  PubMed ID: 16079912
   
  
• Ancient haplotypes of the HLA Class II region.
  Raymond CK, Kas A, Paddock M, Qiu R, Zhou Y, Subramanian S, Chang J, Palmieri A, Haugen E, Kaul R, Olson MV
  Genome Res. 2005
  PubMed ID: 16140993
   
  
• Identification of a new allele, HLA-DRB1*1366*.
  Milia S, Lai S, Valentini T, Testi M, Cappai L, Moscetti A, Mariani M, Alba F, Carcassi C
  Tissue Antigens. 2005
  PubMed ID: 15982265
   
  
• HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma.
  Dorak MT, Yee LJ, Tang J, Shao W, Lobashevsky ES, Jacobson LP, Kaslow RA
  J Med Virol. 2005
  PubMed ID: 15902698
   
  
• Complete coding sequences and haplotypic associations of HLA-B*0707, -B*1524, -B*4405, -B*4802, -DRB1*0409, -DRB1*0411, -DRB1*1115, -DRB1*1305, and the novel allele -DRB1*0709. Group-specific amplification of cDNA from DRB1 alleles associated to DRB3 and
  Vilches C, Sepúlveda S, Balas A, Solís R, Avilés MJ, Estefanía E, Gómez-Lozano N, Vicario JL, dePablo R
  Tissue Antigens. 2005
  PubMed ID: 15896200
   
  
• Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.
  Locher CP, Witt SA, Kassel R, Dowell NL, Fujimura S, Levy JA
  J Gen Virol. 2005
  PubMed ID: 15784911
   
  
• A novel HLA-DRB1*09 allele, HLA-DRB1*090103*, isolated from the Han population of Guangdong, China.
  Hu Z, Liu Z, Xiong Y, Lv F, Fu Y, Lin J, Xu A
  Tissue Antigens. 2005
  PubMed ID: 15730527
   
  
• Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
  Palacios EH, Weiss A
  Oncogene. 2004
  PubMed ID: 15489916
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Identification of a new HLA-DRB1 allele in three members of an Italian family.
  Garino E, Berrino M, Mazzola G, Boccadoro M, Bruno B, Bertinetto F, Bertola L, Caropreso P, Frisaldi E, Marin F, Panniello ML, Tondat F, Dall'Omo AM
  Tissue Antigens. 2004
  PubMed ID: 15245378
   
  
• Identification of a novel HLA-DRB1 allele (DRB1*1147)* by sequence-based typing in eight siblings.
  Li Y, Liao C, Yang X, Tang XW, Wu JY, Huang YN, Xie XM
  Tissue Antigens. 2004
  PubMed ID: 15191533
   
  
• Identification of two novel HLA-DRB1 alleles, DRB1*0903 and DRB1*1145.
  Liu CJ, Chu CC, Lee YJ, Shi YN, Lin M
  Tissue Antigens. 2004
  PubMed ID: 15191532
   
  
• A new HLA-DRB1*11 allele, DRB1*1144, identified by cloning and sequencing.
  Nesci S, Buffi O, Iliescu A, Luchetti M, Battarra MR, Amadei M, Visani G, Andreani M
  Tissue Antigens. 2004
  PubMed ID: 14989721
   
  
• [The relation between the HLA-DRB1*1501 allele and the severity of multiple sclerosis in a sample of the Spanish population from the Balearic Islands: the influence exerted by sex]
  Zabay-Becerril JM, Burcet-Dardé J, Mulet-Ferrer J, Soler-Farré J, Viader-Farré C
  Rev Neurol. 2004
  PubMed ID: 14752708
   
  
• Complete sequencing and characterization of 21,243 full-length human cDNAs.
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  Nat Genet. 2004
  PubMed ID: 14702039
   
  
• Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP.
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  Tissue Antigens. 2003
  PubMed ID: 14617041
   
  
• The DNA sequence and analysis of human chromosome 6.
  Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
  Nature. 2003
  PubMed ID: 14574404
   
  
• HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
  Rossman MD, Thompson B, Frederick M, Maliarik M, Iannuzzi MC, Rybicki BA, Pandey JP, Newman LS, Magira E, Beznik-Cizman B, Monos D, ACCESS Group
  Am J Hum Genet. 2003
  PubMed ID: 14508706
   
  
• Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.
  Schaffer M, Aldener-Cannavá A, Remberger M, Ringdén O, Olerup O
  Tissue Antigens. 2003
  PubMed ID: 12956878
   
  
• A novel HLA-DRB1 allele, DRB1*0707.
  Frison S, Poli F, Longhi E, Bianchi P, Baier DM, Scalamogna M
  Tissue Antigens. 2003
  PubMed ID: 12694577
   
  
• Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups.
  Baldassarre LA, Steiner NK, Jones P, Tang T, Slack R, Ng J, Hartzman RJ, Hurley CK
  Tissue Antigens. 2003
  PubMed ID: 12694574
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Complete cDNA coding sequence of the HLA-DRB1*1405 allele.
  Kohsaka H, Nasu K, Matsushita S, Miyasaka N
  DNA Seq. 2002
  PubMed ID: 12652907
   
  
• A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestry.
  Carrington CV, Kondeatis E, Ramdath DD, Norman PJ, Vaughan RW, Stephens HA
  Hum Immunol. 2002
  PubMed ID: 12392858
   
  
• HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
  Williams MA, Trout R, Spector SA
  J Hematother Stem Cell Res. 2002
  PubMed ID: 12427289
   
  
• Complete cDNA sequences of the HLA-DRB1*0402 and DRB1*11041 alleles.
  Ramon D, Corell A, Cox ST, Soteriou B, Madrigal JA, Marsh SG
  Eur J Immunogenet. 2002
  PubMed ID: 12358860
   
  
• A functional and structural basis for TCR cross-reactivity in multiple sclerosis.
  Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L
  Nat Immunol. 2002
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• Human macrophages accumulate HIV-1 particles in MHC II compartments.
  Raposo G, Moore M, Innes D, Leijendekker R, Leigh-Brown A, Benaroch P, Geuze H
  Traffic. 2002
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• HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy.
  Rihs HP, Chen Z, Ruëff F, Cremer R, Raulf-Heimsoth M, Baur X, Moneret-Vautrin DA, Brüning T
  J Allergy Clin Immunol. 2002
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• HIV-1 gag polyprotein rescues HLA-DR intracellular transport in a human CD4+ cell line.
  Gluschankof P, Suzan M
  Virology. 2002
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• A novel DRB1*09 allelic sequence in the Jing ethnic minority of China.
  Lin J, Liu ZH, Chen W, Jia Z, Pan D, Fu Y, Zhang F, Xu A
  Eur J Immunogenet. 2002
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• HLA-DRB alleles and systemic lupus erythematosus in Jamaicans.
  Smikle M, Christian N, DeCeulaer K, Barton E, Roye-Green K, Dowe G, Anderson N, Nicholson G
  South Med J. 2002
  PubMed ID: 12144077
   
  
• HLA-A, B, Cw, DRB1, DRB3/4/5, DQB1 in German patients suffering from rapidly progressive periodontitis (RPP) and adult periodontitis (AP).
  Machulla HK, Stein J, Gautsch A, Langner J, Schaller HG, Reichert S
  J Clin Periodontol. 2002
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• HLA-DR and DQB1 gene polymorphism in the North-western Colombian population.
  Correa PA, Whitworth WC, Kuffner T, McNicholl J, Anaya JM
  Tissue Antigens. 2002
  PubMed ID: 12144632
   
  
• [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism]
  Song D, Liu Y, Han Y, Shang G, Hua S, Zhang H, Guo S, Jiao S
  Zhonghua Fu Chan Ke Za Zhi. 2002
  PubMed ID: 12133402
   
  
• HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets.
  Galeazzi M, Sebastiani GD, Morozzi G, Carcassi C, Ferrara GB, Scorza R, Cervera R, de Ramon Garrido E, Fernandez-Nebro A, Houssiau F, Jedryka-Goral A, Passiu G, Papasteriades C, Piette JC, Smolen J, Porciello G, Marcolongo R, European Concertee Action on the immunogenetics of SLE
  Medicine (Baltimore). 2002
  PubMed ID: 11997714
   
  
• Novel HLA-DRB1 alleles discovered during routine sequencing based typing, DRB1*03052, DRB1*04032, DRB1*1139 and DRB1*1346.
  Greville WD, Chapman G, Hogbin JP, Kennedy A, Dunckley H
  Tissue Antigens. 2002
  PubMed ID: 12028548
   
  
• Adapters in lymphocyte signaling.
  Leo A, Wienands J, Baier G, Horejsi V, Schraven B
  J Clin Invest. 2002
  PubMed ID: 11827988
   
  
• Complete cDNA sequences of the HLA-DRB1*14011, *1402, *1403 and *1404 alleles.
  Corell A, Cox ST, Soteriou B, Ramon D, Madrigal JA, Marsh SG
  Tissue Antigens. 2002
  PubMed ID: 11972886
   
  
• NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells.
  Zarour HM, Maillere B, Brusic V, Coval K, Williams E, Pouvelle-Moratille S, Castelli F, Land S, Bennouna J, Logan T, Kirkwood JM
  Cancer Res. 2002
  PubMed ID: 11782380
   
  
• Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses.
  Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B
  J Immunol. 2002
  PubMed ID: 11751963
   
  
• Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with systemic lupus erythematosus (SLE).
  Zúñiga J, Vargas-Alarcón G, Hernández-Pacheco G, Portal-Celhay C, Yamamoto-Furusho JK, Granados J
  Genes Immun. 2001
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• Associations of MHC class II alleles in Norwegian primary Sjögren's syndrome patients: implications for development of autoantibodies to the Ro52 autoantigen.
  Nakken B, Jonsson R, Brokstad KA, Omholt K, Nerland AH, Haga HJ, Halse AK
  Scand J Immunol. 2001
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• Presentation of antigens by MHC class II molecules: getting the most out of them.
  Villadangos JA
  Mol Immunol. 2001
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• Association of HLA class II genes with systemic sclerosis in Koreans.
  Kang SH, Park MH, Song EY, Kang SJ, Lee EB, Song YW, Takeuchi F
  J Rheumatol. 2001
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• Description of a new HLA-DRB1 allele, DRB1*1139.
  Longhi E, Frison S, Poli F, Scalamogna M, Sirchia G
  Tissue Antigens. 2001
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• The sequence of the human genome.
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  Science. 2001
  PubMed ID: 11181995
   
  
• A novel HLA-DRB1 sequence, DRB1*11272.
  Ulrich S, Helmberg W, Wagner T, Corell A, Marsh SG, Lanzer G
  Tissue Antigens. 2001
  PubMed ID: 11260517
   
  
• [Two loci HLA haplotypes in celiac children. Linkage imbalance and haplotype frequencies. Comparative study with a control population]
  Ruiz del Prado MY, Olivares López JL, Lázaro Almarza A, Lasierra Díaz MP
  An Esp Pediatr. 2001
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• Identification of a novel DRB1 allele, DRB1*1112, by sequence-based DRB typing.
  Luo M, Blanchard J, Maclean I, Brunham R
  Tissue Antigens. 2001
  PubMed ID: 11169266
   
  
• Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.
  Li Y, Li H, Dimasi N, McCormick JK, Martin R, Schuck P, Schlievert PM, Mariuzza RA
  Immunity. 2001
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• Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
  Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
  Biochem Biophys Res Commun. 2000
  PubMed ID: 11118314
   
  
• Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.
  Li Y, Li H, Martin R, Mariuzza RA
  J Mol Biol. 2000
  PubMed ID: 11080454
   
  
• Sequence analysis of a new HLA-DR11 allele in a Caucasian Italian family: DRB1*11272.
  Canossi A, Piancatelli D, Papola F, Di Rocco M, Del Beato T, Liberatore G, Casciani CU, Adorno D
  Tissue Antigens. 2000
  PubMed ID: 11144300
   
  
• Co-amoxiclav jaundice: clinical and histological features and HLA class II association.
  O'Donohue J, Oien KA, Donaldson P, Underhill J, Clare M, MacSween RN, Mills PR
  Gut. 2000
  PubMed ID: 11034591
   
  
• A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast Asia.
  Stephens HA, Chandanayingyong D, Kunachiwa W, Sirikong M, Longta K, Maneemaroj R, Wongkuttiya D, Sittisombut N, Rungruang E
  Hum Immunol. 2000
  PubMed ID: 11082517
   
  
• Multiple sclerosis associated amino acids of polymorphic regions relevant for the HLA antigen binding are confined to HLA-DR2.
  Zipp F, Windemuth C, Pankow H, Dichgans J, Wienker T, Martin R, Müller C
  Hum Immunol. 2000
  PubMed ID: 11082515
   
  
• The mechanism of phospholipase C-gamma1 regulation.
  Kim MJ, Kim E, Ryu SH, Suh PG
  Exp Mol Med. 2000
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• [Association of HLA-DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China]
  Li F, Shi Y, Shi D
  Zhonghua Yi Xue Za Zhi. 2000
  PubMed ID: 11798795
   
  
• Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
  Poon DT, Coren LV, Ott DE
  J Virol. 2000
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• Detection of four novel alleles: DRB1*1130, DRB1*13072, DRB1*1315 and DRB1*1331.
  Lin YS, Hoyer RJ, Tang TF, Ng J, Hartzmann RJ, Hurley CK
  Tissue Antigens. 2000
  PubMed ID: 10703621
   
  
• Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
  Kanazawa S, Okamoto T, Peterlin BM
  Immunity. 2000
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• Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European Network for Cooperative Research.
  Thursz M, Yallop R, Goldin R, Trepo C, Thomas HC
  Lancet. 1999
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• Two DR2-associated novel alleles arose from the silent mutation of codon 72: DRB1*16012, DRB5*01012.
  Lin YS, Tang TF, Ng J, Hartzman R, Hurley CK
  Tissue Antigens. 1999
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• HLA class I and class II of the Nivkhi, an indigenous population carrying HTLV-I in Sakhalin, Far Eastern Russia.
  Lou H, Li HC, Kuwayama M, Yashiki S, Fujiyoshi T, Suehara M, Osame M, Yamashita M, Hayami M, Gurtsevich V, Ballas M, Imanishi T, Sonoda S
  Tissue Antigens. 1998
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• Description of a new DRB1*11 allele (DRB1*1132).
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  Tissue Antigens. 1998
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• Complete cDNA sequence of the HLA-DRB1*09012 allele.
  Martínez-Quiles N, Martín-Villa JM, Ferre-López S, Moreno-Pelayo MA, Martínez-Laso J, Pérez-Blas M, Alegre R, Arnaiz-Villena A
  Eur J Immunogenet. 1998
  PubMed ID: 9777332
   
  
• Identification of novel DRB1*13 (DRB1*1333), DRB1*04 (DRB1*0426) and DRB5* (DRB5*0109) alleles.
  Buyse IM, Ouellet S, Hashemi-Tavoularis S
  Tissue Antigens. 1998
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• Recent origin of HLA-DRB1 alleles and implications for human evolution.
  Bergström TF, Josefsson A, Erlich HA, Gyllensten U
  Nat Genet. 1998
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• Identification of novel DRB1*11 (DRB1*11013, DRB1*1129), DRB1*08 (DRB1*0816) and DRB5* (DRB5*0107) alleles.
  Buyse IM, Couture C, Hashemi-Tavoularis S
  Tissue Antigens. 1997
  PubMed ID: 9458128
   
  
• The absence of DR51 in a DRB5-positive individual DR2ES is caused by a null allele (DRB5*0108N)
  Voorter CE, Roeffaers HE, du Toit ED, van den Berg-Loonen EM
  Tissue Antigens. 1997
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• Tat protein induces self-perpetuating permissivity for productive HIV-1 infection.
  Li CJ, Ueda Y, Shi B, Borodyansky L, Huang L, Li YZ, Pardee AB
  Proc Natl Acad Sci U S A. 1997
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• Sequence of a new HLA-DR allele, DRB5*0106.
  Kervaire B, Tiercy JM
  Eur J Immunogenet. 1997
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• The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
  Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
  J Biol Chem. 1997
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• Diversity associated with the second expressed HLA-DRB locus in the human population.
  Robbins F, Hurley CK, Tang T, Yao H, Lin YS, Wade J, Goeken N, Hartzman RJ
  Immunogenetics. 1997
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• A new DRB1 allele (DRB1*1125) sharing DR11 and DR8 sequence motifs.
  Perrier P, Reveillère C, Schuhmacher A
  Tissue Antigens. 1997
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• A new allelic variant of HLA-DRB1*1101 (DRB1*11013) segregating in a Sardinian family.
  Murru MR, Costa G, Murru R, Muntoni F, Marrosu MG
  Tissue Antigens. 1996
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• New DRB1*1120 allele; another example of the transition between the DR11 and DR13 families of alleles.
  Cizman BB, Kearns DJ, McKeen ME, Heron SD, Wu J, Griffith BB, Argyris EG, Kamoun M, Zmijewski CM, Williams TM, Monos DS
  Tissue Antigens. 1996
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• Characterization of a new HLA-DRB5 allele (DRB5*0105) by PCR-SSP and direct sequencing.
  Poli F, Bianchi P, Crespiatico L, Terragna C, van den Berg-Loonen E, Sirchia G
  Tissue Antigens. 1996
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• Invariant chain structure and MHC class II function.
  Cresswell P
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