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HLA-DRA

Gene Description:   RT1 class II, locus Da; major histocompatibility complex, class II, DR alpha; histocompatibility 2, class II antigen E alpha, pseudogene Synonyms:   RT1-Da, E-alpha-f, HLA-DRA, HLA-DRA1, H-2Ea, FLJ51114, Ia-3, I-Ealpha, Ia3, RT1-u, AI323765, MLRW, MGC117888, MGC112637, H2-Ea, H2-Ea-ps Orthologs:   Human HLA-DRA (protein-coding), Mouse H2-Ea-ps (protein-coding), Rat RT1-Da (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD Human-Rat: HomoloGene, Inparanoid, OrthoMCL Mouse-Rat: HomoloGene Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd1	Mouse	chr17:34132973..35404440	1.27	98	6 no lod score

(Human) GRCh37 - chr6:32407619..32412823 (5.20 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr17:34478902..34484492 (5.59 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr20:4636310..4641282 (4.97 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas           no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HLA-DRA: The HLA-DRA interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HLA-DRA   PRPF40B   HPRD  empirical  9700202  HLA-DRA   HLA-DMA   HPRD, IntAct  empirical  9371817  8574855  11070170  21131964  HLA-DRA   HLA-DMB   HPRD, BioGRID  empirical  8920889  9371817  12932352  7648393  10716924  8574855  HLA-DRA   HLA-DRB1   HPRD, MINT, Reactome  empirical  9354468  7477400  11432818  HLA-DRA   HLA-DRB3   Reactome  predicted    HLA-DRA   HLA-DRB4   IntAct, Reactome  empirical  21131964  11877480  HLA-DRA   HLA-DRB5   HPRD, Reactome  empirical  12244309  HLA-DRA   CD82   HPRD, BioGRID  empirical  9759843  HLA-DRA   MBP   HPRD, BioGRID  empirical  9782128  HLA-DRA   CD63   HPRD, BioGRID  empirical  9759843  HLA-DRA   CD74   HPRD, MINT  empirical  16242130

View all

KEGG Network: 18   Allograft rejection Human - 5330 Mouse - 5330 Rat - 5330 Antigen processing and presentation Human - 4612 Mouse - 4612 Rat - 4612 Asthma Human - 5310 Mouse - 5310 Rat - 5310 Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Graft-versus-host disease Human - 5332 Mouse - 5332 Rat - 5332 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Influenza A Human - 5164 Mouse - 5164 Rat - 5164 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Leishmaniasis Human - 5140 Mouse - 5140 Rat - 5140 Phagosome Human - 4145 Mouse - 4145 Rat - 4145 Rheumatoid arthritis Human - 5323 Mouse - 5323 Rat - 5323 Staphylococcus aureus infection Human - 5150 Mouse - 5150 Rat - 5150 Systemic lupus erythematosus Human - 5322 Mouse - 5322 Rat - 5322 Toxoplasmosis Human - 5145 Mouse - 5145 Rat - 5145 Tuberculosis Human - 5152 Mouse - 5152 Rat - 5152 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940 Viral myocarditis Human - 5416 Mouse - 5416 Rat - 5416

Biocarta: 11   Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor Human Antigen Dependent B Cell Activation Human Antigen Processing and Presentation Human B Lymphocyte Cell Surface Molecules Human Bystander B Cell Activation Human Cytokines and Inflammatory Response Human IL 5 Signaling Pathway Human Lck and Fyn tyrosine kinases in initiation of TCR Activation Human Th1/Th2 Differentiation Human The Co-Stimulatory Signal During T-cell Activation Human The Role of Eosinophils in the Chemokine Network of Allergy Human

Reactome: 7   Costimulation by the CD28 family REACT_19344 Downstream TCR signaling REACT_12555 Generation of second messenger molecules REACT_12623 PD-1 signaling REACT_19324 Phosphorylation of CD3 and TCR zeta chains REACT_12582 TCR signaling REACT_12526 Translocation of ZAP-70 to Immunological synapse REACT_12596

NCI-Nature Pathway Interaction Database: 4   TCR signaling in naïve CD4+ T cells CXCR4-mediated signaling events IL12 signaling mediated by STAT4 IL12-mediated signaling events

Gene Ontology: 19   Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosome GO:0005764 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Membrane GO:0016020 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 Late endosome membrane GO:0031902 MHC class II receptor activity GO:0032395 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

	KEGG Network: 18 Allograft rejection Human - 5330 Mouse - 5330 Rat - 5330 Antigen processing and presentation Human - 4612 Mouse - 4612 Rat - 4612 Asthma Human - 5310 Mouse - 5310 Rat - 5310 Autoimmune thyroid disease Human - 5320 Mouse - 5320 Rat - 5320 Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Graft-versus-host disease Human - 5332 Mouse - 5332 Rat - 5332 Hematopoietic cell lineage Human - 4640 Mouse - 4640 Rat - 4640 Influenza A Human - 5164 Mouse - 5164 Rat - 5164 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Leishmaniasis Human - 5140 Mouse - 5140 Rat - 5140 Phagosome Human - 4145 Mouse - 4145 Rat - 4145 Rheumatoid arthritis Human - 5323 Mouse - 5323 Rat - 5323 Staphylococcus aureus infection Human - 5150 Mouse - 5150 Rat - 5150 Systemic lupus erythematosus Human - 5322 Mouse - 5322 Rat - 5322 Toxoplasmosis Human - 5145 Mouse - 5145 Rat - 5145 Tuberculosis Human - 5152 Mouse - 5152 Rat - 5152 Type I diabetes mellitus Human - 4940 Mouse - 4940 Rat - 4940 Viral myocarditis Human - 5416 Mouse - 5416 Rat - 5416
	Biocarta: 11 Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor Human Antigen Dependent B Cell Activation Human Antigen Processing and Presentation Human B Lymphocyte Cell Surface Molecules Human Bystander B Cell Activation Human Cytokines and Inflammatory Response Human IL 5 Signaling Pathway Human Lck and Fyn tyrosine kinases in initiation of TCR Activation Human Th1/Th2 Differentiation Human The Co-Stimulatory Signal During T-cell Activation Human The Role of Eosinophils in the Chemokine Network of Allergy Human
	Reactome: 7 Costimulation by the CD28 family REACT_19344 Downstream TCR signaling REACT_12555 Generation of second messenger molecules REACT_12623 PD-1 signaling REACT_19324 Phosphorylation of CD3 and TCR zeta chains REACT_12582 TCR signaling REACT_12526 Translocation of ZAP-70 to Immunological synapse REACT_12596
	NCI-Nature Pathway Interaction Database: 4 TCR signaling in naïve CD4+ T cells CXCR4-mediated signaling events IL12 signaling mediated by STAT4 IL12-mediated signaling events
	Gene Ontology: 19 Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosome GO:0005764 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Membrane GO:0016020 Integral to membrane GO:0016021 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 Late endosome membrane GO:0031902 MHC class II receptor activity GO:0032395 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

Type 1 Diabetes Publications: 13

• Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
  Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
  Nat Genet. 2009
  PubMed ID: 19430480
   
  
• Do non-HLA Genes Influence Development of Persistent Islet Autoimmunity and Type 1 Diabetes in Children with High-Risk HLA-DR,DQ Genotypes?
  Steck AK, Zhang W, Bugawan TL, Barriga KJ, Blair A, Erlich HA, Eisenbarth GS, Norris JM, Rewers MJ
  Diabetes. 2009
  PubMed ID: 19188433
   
  
• Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.
  McKinnon E, Morahan G, Nolan D, James I, Diabetes Genetics Consortium
  Diabetes Obes Metab. 2009
  PubMed ID: 19143821
   
  
• Risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group in Sweden.
  Sanjeevi CB, Sedimbi SK, Landin-Olsson M, Kockum I, Lernmark A, Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups
  Ann N Y Acad Sci. 2008
  PubMed ID: 19120278
   
  
• Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.
  Shastry A, Sedimbi SK, Rajalingam R, Nikitina-Zake L, Rumba I, Wigzell H, Sanjeevi CB
  Int J Immunogenet. 2008
  PubMed ID: 19046302
   
  
• Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families.
  Eike MC, Olsson M, Undlien DE, Dahl-Jørgensen K, Joner G, Rønningen KS, Thorsby E, Lie BA
  Genes Immun. 2008
  PubMed ID: 18987644
   
  
• Crystallographic structure of the human leukocyte antigen DRA, DRB3*0101: models of a directional alloimmune response and autoimmunity.
  Parry CS, Gorski J, Stern LJ
  J Mol Biol. 2007
  PubMed ID: 17583734
   
  
• Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis.
  Flynn JC, Wan Q, Panos JC, McCormick DJ, Giraldo AA, David CS, Kong YC
  J Autoimmun. 2002
  PubMed ID: 12126634
   
  
• T-cell tolerance by dendritic cells and macrophages as a mechanism for the major histocompatibility complex-linked resistance to autoimmune diabetes.
  Thiessen S, Serra P, Amrani A, Verdaguer J, Santamaria P
  Diabetes. 2002
  PubMed ID: 11812739
   
  
• Molecular analysis of the pathogenesis of autoimmune insulitis in NOD mice.
  Koide Y, Kaidoh T, Nakamura M, Yoshida TO
  Tohoku J Exp Med. 1994
  PubMed ID: 7809906
   
  
• Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocks.
  Prochazka M, Serreze DV, Worthen SM, Leiter EH
  Diabetes. 1989
  PubMed ID: 2576007
   
  
• The complete sequence of the MHC class II chain RT.1D alpha u of the diabetic BB rat: mRNA levels of RT1.D alpha in lymphocytes.
  Holowachuk EW, Greer MK, Martin DR
  Nucleic Acids Res. 1987
  PubMed ID: 3122183
   
  
• The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex.
  Hattori M, Buse JB, Jackson RA, Glimcher L, Dorf ME, Minami M, Makino S, Moriwaki K, Kuzuya H, Imura H
  Science. 1986
  PubMed ID: 3003909
   
  

Publications: 260

• HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease.
  Guo Y, Deng X, Zheng W, Xu H, Song Z, Liang H, Lei J, Jiang X, Luo Z, Deng H
  Neurosci Lett. 2011
  PubMed ID: 21791235
   
  
• Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.
  Eleftherohorinou H, Hoggart CJ, Wright VJ, Levin M, Coin LJ
  Hum Mol Genet. 2011
  PubMed ID: 21653640
   
  
• Inflammation and epithelial cell injury in AIDS enteropathy: involvement of endoplasmic reticulum stress.
  Maingat F, Halloran B, Acharjee S, van Marle G, Church D, Gill MJ, Uwiera RR, Cohen EA, Meddings J, Madsen K, Power C
  FASEB J. 2011
  PubMed ID: 21427211
   
  
• Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.
  Wright FA, Strug LJ, Doshi VK, Commander CW, Blackman SM, Sun L, Berthiaume Y, Cutler D, Cojocaru A, Collaco JM, Corey M, Dorfman R, Goddard K, Green D, Kent JW, Lange EM, Lee S, Li W, Luo J, Mayhew GM, Naughton KM, Pace RG, Paré P, Rommens JM, Sandford A, Stonebraker JR, Sun W, Taylor C, Vanscoy LL, Zou F, Blangero J, Zielenski J, O'Neal WK, Drumm ML, Durie PR, Knowles MR, Cutting GR
  Nat Genet. 2011
  PubMed ID: 21602797
   
  
• Human leukocyte antigen variation and Parkinson's disease.
  Puschmann A, Verbeeck C, Heckman MG, Soto-Ortolaza AI, Lynch T, Jasinska-Myga B, Opala G, Krygowska-Wajs A, Barcikowska M, Uitti RJ, Wszolek ZK, Ross OA
  Parkinsonism Relat Disord. 2011
  PubMed ID: 21482477
   
  
• Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
  Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD
  Nat Genet. 2011
  PubMed ID: 21297633
   
  
• Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions.
  Taflin C, Favier B, Baudhuin J, Savenay A, Hemon P, Bensussan A, Charron D, Glotz D, Mooney N
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21282653
   
  
• Initial characterization of the human central proteome.
  Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
  BMC Syst Biol. 2011
  PubMed ID: 21269460
   
  
• A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
  Enciso-Mora V, Broderick P, Ma Y, Jarrett RF, Hjalgrim H, Hemminki K, van den Berg A, Olver B, Lloyd A, Dobbins SE, Lightfoot T, van Leeuwen FE, Försti A, Diepstra A, Broeks A, Vijayakrishnan J, Shield L, Lake A, Montgomery D, Roman E, Engert A, von Strandmann EP, Reiners KS, Nolte IM, Smedby KE, Adami HO, Russell NS, Glimelius B, Hamilton-Dutoit S, de Bruin M, Ryder LP, Molin D, Sorensen KM, Chang ET, Taylor M, Cooke R, Hofstra R, Westers H, van Wezel T, van Eijk R, Ashworth A, Rostgaard K, Melbye M, Swerdlow AJ, Houlston RS
  Nat Genet. 2010
  PubMed ID: 21037568
   
  
• Serial analysis of biomarkers of acute pancreas allograft rejection.
  Cashion AK, Sabek O, Driscoll C, Gaber L, Tolley E, Gaber AO
  Clin Transplant. 2010
  PubMed ID: 20497195
   
  
• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
  Diabetes Care. 2010
  PubMed ID: 20628086
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
  Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, Kay DM, Doheny KF, Paschall J, Pugh E, Kusel VI, Collura R, Roberts J, Griffith A, Samii A, Scott WK, Nutt J, Factor SA, Payami H
  Nat Genet. 2010
  PubMed ID: 20711177
   
  
• Up-regulation of MHC class I and class II in the skeletal muscles of myasthenia gravis.
  Iwasa K, Kato-Motozaki Y, Furukawa Y, Maruta T, Ishida C, Yoshikawa H, Yamada M
  J Neuroimmunol. 2010
  PubMed ID: 20546939
   
  
• Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.
  Sombekke MH, Arteta D, van de Wiel MA, Crusius JB, Tejedor D, Killestein J, Martínez A, Peña AS, Polman CH, Uitdehaag BM
  Mult Scler. 2010
  PubMed ID: 20378664
   
  
• Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
  Jin Y, Birlea SA, Fain PR, Gowan K, Riccardi SL, Holland PJ, Mailloux CM, Sufit AJ, Hutton SM, Amadi-Myers A, Bennett DC, Wallace MR, McCormack WT, Kemp EH, Gawkrodger DJ, Weetman AP, Picardo M, Leone G, Taïeb A, Jouary T, Ezzedine K, van Geel N, Lambert J, Overbeck A, Spritz RA
  N Engl J Med. 2010
  PubMed ID: 20410501
   
  
• The impacts of continuous veno-venous hemofiltration on plasma cytokines and monocyte human leukocyte antigen-DR expression in septic patients.
  Peng Z, Pai P, Hong-Bao L, Rong L, Han-Min W, Chen H
  Cytokine. 2010
  PubMed ID: 20202859
   
  
• Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record.
  Ritchie MD, Denny JC, Crawford DC, Ramirez AH, Weiner JB, Pulley JM, Basford MA, Brown-Gentry K, Balser JR, Masys DR, Haines JL, Roden DM
  Am J Hum Genet. 2010
  PubMed ID: 20362271
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
  Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH, IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S
  Nat Genet. 2010
  PubMed ID: 20228798
   
  
• Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions.
  Csillag A, Boldogh I, Pazmandi K, Magyarics Z, Gogolak P, Sur S, Rajnavolgyi E, Bacsi A
  J Immunol. 2010
  PubMed ID: 20118277
   
  
• Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
  Jakkula E, Leppä V, Sulonen AM, Varilo T, Kallio S, Kemppinen A, Purcell S, Koivisto K, Tienari P, Sumelahti ML, Elovaara I, Pirttilä T, Reunanen M, Aromaa A, Oturai AB, Søndergaard HB, Harbo HF, Mero IL, Gabriel SB, Mirel DB, Hauser SL, Kappos L, Polman C, De Jager PL, Hafler DA, Daly MJ, Palotie A, Saarela J, Peltonen L
  Am J Hum Genet. 2010
  PubMed ID: 20159113
   
  
• Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.
  Festen EA, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen HM, Crusius BJ, Hommes DW, van der Woude CJ, van der Woude JC, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK
  Am J Gastroenterol. 2010
  PubMed ID: 19861958
   
  
• Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
  Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vander Cruyssen B, Peeters H, Elewaut D, De Vos M
  PLoS One. 2010
  PubMed ID: 21072187
   
  
• Positive and negative predictive values of HLA-DR and CD34 in the diagnosis of acute promyelocytic leukemia and other types of acute myeloid leukemia with recurrent chromosomal translocations.
  Promsuwicha O, Auewarakul CU
  Asian Pac J Allergy Immunol. 2009
  PubMed ID: 20232575
   
  
• Common genetic variation and the control of HIV-1 in humans.
  Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, Mallal S, Mussini C, Dalmau J, Martinez-Picado J, Miro JM, Obel N, Wolinsky SM, Martinson JJ, Detels R, Margolick JB, Jacobson LP, Descombes P, Antonarakis SE, Beckmann JS, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, Carrington M, Feng S, Telenti A, Goldstein DB, NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
  PLoS Genet. 2009
  PubMed ID: 20041166
   
  
• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
  Am J Hum Genet. 2009
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• Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.
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  J Hum Genet. 2009
  PubMed ID: 19834503
   
  
• A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
  Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A, Teumer A, Willenborg C, Wright B, Chen L, Li M, Salo P, Voight BF, Burns P, Laskowski RA, Xue Y, Menzel S, Altshuler D, Bradley JR, Bumpstead S, Burnett MS, Devaney J, Döring A, Elosua R, Epstein SE, Erber W, Falchi M, Garner SF, Ghori MJ, Goodall AH, Gwilliam R, Hakonarson HH, Hall AS, Hammond N, Hengstenberg C, Illig T, König IR, Knouff CW, McPherson R, Melander O, Mooser V, Nauck M, Nieminen MS, O'Donnell CJ, Peltonen L, Potter SC, Prokisch H, Rader DJ, Rice CM, Roberts R, Salomaa V, Sambrook J, Schreiber S, Schunkert H, Schwartz SM, Serbanovic-Canic J, Sinisalo J, Siscovick DS, Stark K, Surakka I, Stephens J, Thompson JR, Völker U, Völzke H, Watkins NA, Wells GA, Wichmann HE, Van Heel DA, Tyler-Smith C, Thein SL, Kathiresan S, Perola M, Reilly MP, Stewart AF, Erdmann J, Samani NJ, Meisinger C, Greinacher A, Deloukas P, Ouwehand WH, Gieger C
  Nat Genet. 2009
  PubMed ID: 19820697
   
  
• The 19S proteasome positively regulates histone methylation at cytokine inducible genes.
  Koues OI, Dudley RK, Mehta NT, Greer SF
  Biochim Biophys Acta. 2009
  PubMed ID: 19660582
   
  
• Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients.
  Kong SL, Chui P, Lim B, Salto-Tellez M
  Virus Res. 2009
  PubMed ID: 19635508
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
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  PLoS Genet. 2009
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• The binding of antigenic peptides to HLA-DR is influenced by interactions between pocket 6 and pocket 9.
  James EA, Moustakas AK, Bui J, Nouv R, Papadopoulos GK, Kwok WW
  J Immunol. 2009
  PubMed ID: 19648278
   
  
• Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
  De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, International MS Genetics Consortium, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR
  Nat Genet. 2009
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• CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
  Beswick EJ, Reyes VE
  World J Gastroenterol. 2009
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• Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.
  Cui J, Taylor KE, Destefano AL, Criswell LA, Izmailova ES, Parker A, Roubenoff R, Plenge RM, Weinblatt ME, Shadick NA, Karlson EW
  Mol Med. 2009
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• Analyses of associations with asthma in four asthma population samples from Canada and Australia.
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  Hum Genet. 2009
  PubMed ID: 19247692
   
  
• The HLA-DRalpha chain is modified by polyubiquitination.
  Lapaque N, Jahnke M, Trowsdale J, Kelly AP
  J Biol Chem. 2009
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• Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
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  Mol Psychiatry. 2009
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• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
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  J Proteome Res. 2009
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• Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
  Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Paré P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH
  Nat Genet. 2009
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• Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.
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  Arthritis Rheum. 2009
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• MHC class II transport at a glance.
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  J Cell Sci. 2009
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• HLA-A33 is associated with susceptibility to enterovirus 71 infection.
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  Pediatrics. 2008
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• Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
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  Nat Genet. 2008
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• Association of Smoking Behavior with an Odorant Receptor Allele Telomeric to the Human Major Histocompatibility Complex.
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  Genet Test. 2008
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• [Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance]
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  Beijing Da Xue Xue Bao. 2008
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• Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect.
  Vermeulen BA, Hogen Esch CE, Yuksel Z, Koning F, Verduijn W, Doxiadis II, Schreuder GM, Luisa Mearin M
  Scand J Gastroenterol. 2008
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• The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.
  Dai S, Crawford F, Marrack P, Kappler JW
  Proc Natl Acad Sci U S A. 2008
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• Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese.
  Umemura T, Ota M, Yoshizawa K, Katsuyama Y, Ichijo T, Tanaka E, Kiyosawa K
  Hepatol Res. 2008
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• [Human leukocyte antigen genes to genetic predisposition in diffuse panbonchiolitis]
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• MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation.
  De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E
  Proc Natl Acad Sci U S A. 2008
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• MHC class II molecules on the move for successful antigen presentation.
  Rocha N, Neefjes J
  EMBO J. 2008
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• HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivo.
  Bulwin GC, Wälter S, Schlawinsky M, Heinemann T, Schulze A, Höhne W, Krause G, Kalka-Moll W, Fraser P, Volk HD, Löhler J, Milford EL, Utku N
  PLoS ONE. 2008
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• Risk alleles for multiple sclerosis identified by a genomewide study.
  International Multiple Sclerosis Genetics Consortium, Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL, de Bakker PI, Gabriel SB, Mirel DB, Ivinson AJ, Pericak-Vance MA, Gregory SG, Rioux JD, McCauley JL, Haines JL, Barcellos LF, Cree B, Oksenberg JR, Hauser SL
  N Engl J Med. 2007
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• Cerebral cavernomas and human leukocyte antigens: preliminary clinical results.
  Sanus GZ, Hanimoglu H, Tanriverdi T, Yilmaz E, Ak H, Ulu MO, Kafadar AM, Canbaz B, Kaynar MY
  Surg Neurol. 2007
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• Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock.
  Venet F, Tissot S, Debard AL, Faudot C, Crampé C, Pachot A, Ayala A, Monneret G
  Crit Care Med. 2007
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• Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
  Qi Q, August A
  Sci STKE. 2007
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• Autophagy in MHC class II presentation: sampling from within.
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  Immunity. 2007
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• Major histocompatibility complex class II molecules promote human immunodeficiency virus type 1 assembly and budding to late endosomal/multivesicular body compartments.
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• Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation.
  Nakatani N, Hattori E, Ohnishi T, Dean B, Iwayama Y, Matsumoto I, Kato T, Osumi N, Higuchi T, Niwa S, Yoshikawa T
  Hum Mol Genet. 2006
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• Modelling thymic HIV-1 Nef effects.
  Stove V, Verhasselt B
  Curr HIV Res. 2006
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• Transcriptome analysis of human gastric cancer.
  Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
  Mamm Genome. 2005
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• Assembly of major histocompatibility complex class II subunits with invariant chain.
  Neumann J, Koch N
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• Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
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  Cell Res. 2005
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• Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.
  Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA
  EMBO J. 2005
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• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
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• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
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• Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb.
  Subramanian S, Yim YS, Liu K, Tus K, Zhou XJ, Wakeland EK
  J Immunol. 2005
  PubMed ID: 16002707
   
  
• Tumor HLA-DR expression linked to early intrahepatic recurrence of hepatocellular carcinoma.
  Matoba K, Iizuka N, Gondo T, Ishihara T, Yamada-Okabe H, Tamesa T, Takemoto N, Hashimoto K, Sakamoto K, Miyamoto T, Uchimura S, Hamamoto Y, Oka M
  Int J Cancer. 2005
  PubMed ID: 15688398
   
  
• Association of fulminant non-A non-B hepatitis with homozygosity for HLA A1-B8-DR3.
  Gow P, Hathaway M, Gunson B, Heward J, Mutimer D
  J Gastroenterol Hepatol. 2005
  PubMed ID: 15836703
   
  
• Differential effects of R5 and X4 human immunodeficiency virus type 1 infection on CD4+ cell proliferation and activation.
  Locher CP, Witt SA, Kassel R, Dowell NL, Fujimura S, Levy JA
  J Gen Virol. 2005
  PubMed ID: 15784911
   
  
• Peptide motif for the rat MHC class II molecule RT1.Da: similarities to the multiple sclerosis-associated HLA-DRB1*1501 molecule.
  Duyar H, Dengjel J, de Graaf KL, Wiesmüller KH, Stevanović S, Weissert R
  Immunogenetics. 2005
  PubMed ID: 15711804
   
  
• Messenger RNA expression of major histocompatibility complex class II genes in whole blood from septic shock patients.
  Pachot A, Monneret G, Brion A, Venet F, Bohé J, Bienvenu J, Mougin B, Lepape A
  Crit Care Med. 2005
  PubMed ID: 15644645
   
  
• Gene and alternative splicing annotation with AIR.
  Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
  Genome Res. 2005
  PubMed ID: 15632090
   
  
• Detection of a new cerebral malaria susceptibility locus, using CBA mice.
  Ohno T, Nishimura M
  Immunogenetics. 2004
  PubMed ID: 15536567
   
  
• Genetic basis of the latex-fruit syndrome: association with HLA class II alleles in a Spanish population.
  Blanco C, Sánchez-García F, Torres-Galván MJ, Dumpierrez AG, Almeida L, Figueroa J, Ortega N, Castillo R, Gallego MD, Carrillo T
  J Allergy Clin Immunol. 2004
  PubMed ID: 15536412
   
  
• Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles.
  Ettinger RA, Moustakas AK, Lobaton SD
  Immunogenetics. 2004
  PubMed ID: 15517241
   
  
• In silico genetics: identification of a functional element regulating H2-Ealpha gene expression.
  Liao G, Wang J, Guo J, Allard J, Cheng J, Ng A, Shafer S, Puech A, McPherson JD, Foernzler D, Peltz G, Usuka J
  Science. 2004
  PubMed ID: 15499019
   
  
• Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
  Palacios EH, Weiss A
  Oncogene. 2004
  PubMed ID: 15489916
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
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• Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers.
  Rangel LB, Agarwal R, Sherman-Baust CA, Mello-Coelho V, Pizer ES, Ji H, Taub DD, Morin PJ
  Cancer Biol Ther. 2004
  PubMed ID: 15467430
   
  
• Microgeographic variation of HLA-A, -B, and -DR haplotype frequencies in Tuscany, Italy: implications for recruitment of bone marrow donors.
  Marroni F, Curcio M, Fornaciari S, Lapi S, Mariotti ML, Scatena F, Presciuttini S
  Tissue Antigens. 2004
  PubMed ID: 15361126
   
  
• Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter.
  Osborne AR, Zhang H, Fejer G, Palubin KM, Niesen MI, Blanck G
  J Biol Chem. 2004
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• HLA genotypes in Turkish patients with myasthenia gravis: comparison with multiple sclerosis patients on the basis of clinical subtypes and demographic features.
  Dönmez B, Ozakbas S, Oktem MA, Gedizlioglu M, Coker I, Genc A, Idiman E
  Hum Immunol. 2004
  PubMed ID: 15301866
   
  
• Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.
  Kirchhoff F, Schindler M, Bailer N, Renkema GH, Saksela K, Knoop V, Müller-Trutwin MC, Santiago ML, Bibollet-Ruche F, Dittmar MT, Heeney JL, Hahn BH, Münch J
  J Virol. 2004
  PubMed ID: 15194762
   
  
• Delineation of the HLA-DR region and the residues involved in the association with the cytoskeleton.
  El Fakhry Y, Bouillon M, Léveillé C, Brunet A, Khalil H, Thibodeau J, Mourad W
  J Biol Chem. 2004
  PubMed ID: 14976194
   
  
• HIV accessory proteins and surviving the host cell.
  Anderson JL, Hope TJ
  Curr HIV/AIDS Rep. 2004
  PubMed ID: 16091223
   
  
• HIV/SIV escape from immune surveillance: focus on Nef.
  Tolstrup M, Ostergaard L, Laursen AL, Pedersen SF, Duch M
  Curr HIV Res. 2004
  PubMed ID: 15078178
   
  
• The genomic sequence and comparative analysis of the rat major histocompatibility complex.
  Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
  Genome Res. 2004
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• Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
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