• About T1DBase
• Regions
  • Human T1D Regions
  • Mouse T1D Regions
    • Linkage Regions
    • Orthologous Regions
  • Rat T1D Regions
    • Linkage Regions
    • Orthologous Regions
    • QTL Regions
• Genome Browser
  • Human GBrowse
  • Mouse GBrowse
  • Rat GBrowse
• Tools
  • Gene Dossier
  • Beta Cell Gene Atlas
  • Batch Query
  • Sequence Search
  • HaemAtlas Search
  • Mouse Strain Search
• Data
  • Poster Pages
  • Downloads
  • Data Submission
• Help
  • FAQ
  • T1DBase Tutorial
• Contact Us

• Page Sections
  • Summary
  • Regions of Interest Overlapping this feature
  • Gene Overview
  • Beta Cell Gene Atlas
  • Tissue Expression
  • HaemAtlas Expression
  • Interactions
  • Cross-Reference to Pathways and GO Terms
  • Publications
  • Model Organism Phenotype Links
  • External Links
  • External resources (dkCOIN)

HLA-DQA2

Gene Description:   major histocompatibility complex, class II, DQ alpha 2 Synonyms:   HLA-DXA, HLA-DQA2, DX-ALPHA Orthologs:   Human HLA-DQA2 (protein-coding)   Sources Sources Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

(Human) GRCh37 - chr6:32709119..32715219 (6.10 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas no data no data no data no data no data no data no data no data no data no data no data no data no data

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for HLA-DQA2: The HLA-DQA2 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs HLA-DQA2   HLA-DQB1   HPRD, Reactome  empirical  9036956  HLA-DQA2   HLA-DQB2   Reactome  predicted    HLA-DQA2   INS   HPRD  empirical  11376336  HLA-DQA2   CD4   HPRD  empirical  11535811

View all

KEGG Network: 17   Allograft rejection Human - 5330 Antigen processing and presentation Human - 4612 Asthma Human - 5310 Autoimmune thyroid disease Human - 5320 Cell adhesion molecules (CAMs) Human - 4514 Graft-versus-host disease Human - 5332 Influenza A Human - 5164 Intestinal immune network for IgA production Human - 4672 Leishmaniasis Human - 5140 Phagosome Human - 4145 Rheumatoid arthritis Human - 5323 Staphylococcus aureus infection Human - 5150 Systemic lupus erythematosus Human - 5322 Toxoplasmosis Human - 5145 Tuberculosis Human - 5152 Type I diabetes mellitus Human - 4940 Viral myocarditis Human - 5416

Biocarta: None available   None available.

Reactome: 7   Costimulation by the CD28 family REACT_19344 Downstream TCR signaling REACT_12555 Generation of second messenger molecules REACT_12623 PD-1 signaling REACT_19324 Phosphorylation of CD3 and TCR zeta chains REACT_12582 TCR signaling REACT_12526 Translocation of ZAP-70 to Immunological synapse REACT_12596

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 16   Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Endosome membrane GO:0010008 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 MHC class II receptor activity GO:0032395 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

	KEGG Network: 17 Allograft rejection Human - 5330 Antigen processing and presentation Human - 4612 Asthma Human - 5310 Autoimmune thyroid disease Human - 5320 Cell adhesion molecules (CAMs) Human - 4514 Graft-versus-host disease Human - 5332 Influenza A Human - 5164 Intestinal immune network for IgA production Human - 4672 Leishmaniasis Human - 5140 Phagosome Human - 4145 Rheumatoid arthritis Human - 5323 Staphylococcus aureus infection Human - 5150 Systemic lupus erythematosus Human - 5322 Toxoplasmosis Human - 5145 Tuberculosis Human - 5152 Type I diabetes mellitus Human - 4940 Viral myocarditis Human - 5416
	Biocarta: None available
	Reactome: 7 Costimulation by the CD28 family REACT_19344 Downstream TCR signaling REACT_12555 Generation of second messenger molecules REACT_12623 PD-1 signaling REACT_19324 Phosphorylation of CD3 and TCR zeta chains REACT_12582 TCR signaling REACT_12526 Translocation of ZAP-70 to Immunological synapse REACT_12596
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 16 Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 Lysosomal membrane GO:0005765 Endosome GO:0005768 Endoplasmic reticulum GO:0005783 Endoplasmic reticulum membrane GO:0005789 Golgi apparatus GO:0005794 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 Endosome membrane GO:0010008 Cytokine-mediated signaling pathway GO:0019221 T cell costimulation GO:0031295 MHC class II receptor activity GO:0032395 MHC class II protein complex GO:0042613 T cell receptor signaling pathway GO:0050852 Interferon-gamma-mediated signaling pathway GO:0060333

Type 1 Diabetes Publications: 5

• The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1.
  Husain Z, Kelly MA, Eisenbarth GS, Pugliese A, Awdeh ZL, Larsen CE, Alper CA
  J Autoimmun. 2008
  PubMed ID: 18065200
   
  
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
  Wellcome Trust Case Control Consortium
  Nature. 2007
  PubMed ID: 17554300
   
  
• Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes.
  Lee KH, Wucherpfennig KW, Wiley DC
  Nat Immunol. 2001
  PubMed ID: 11376336
   
  
• Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer.
  Rudy G, Lew AM
  Hum Immunol. 1994
  PubMed ID: 8026991
   
  
• Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals.
  Horn GT, Bugawan TL, Long CM, Manos MM, Erlich HA
  Hum Immunol. 1988
  PubMed ID: 3372263
   
  

Publications: 48

• Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
  Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, SLEGEN, Petri M, Demirci FY, Kamboh MI, Manzi S, Gregersen PK, Langefeld CD, Behrens TW, Criswell LA
  PLoS Genet. 2011
  PubMed ID: 21408207
   
  
• Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
  Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
  Mol Hum Reprod. 2010
  PubMed ID: 20587610
   
  
• Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
  Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers GJ, Donjacour CE, Iranzo A, Santamaria J, Peraita Adrados R, Vicario JL, Overeem S, Arnulf I, Theodorou I, Jennum P, Knudsen S, Bassetti C, Mathis J, Lecendreux M, Mayer G, Geisler P, Benetó A, Petit B, Pfister C, Bürki JV, Didelot G, Billiard M, Ercilla G, Verduijn W, Claas FH, Vollenwider P, Waeber G, Waterworth DM, Mooser V, Heinzer R, Beckmann JS, Bergmann S, Tafti M
  Nat Genet. 2010
  PubMed ID: 20711174
   
  
• Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
  Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM
  Nature. 2010
  PubMed ID: 20596022
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
  Li X, Howard TD, Zheng SL, Haselkorn T, Peters SP, Meyers DA, Bleecker ER
  J Allergy Clin Immunol. 2010
  PubMed ID: 20159242
   
  
• New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.
  Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, Furuichi T, Dai J, Sudo A, Uchida A, Fukui N, Kubo M, Kamatani N, Tsunoda T, Malizos KN, Tsezou A, Gonzalez A, Nakamura Y, Ikegawa S
  PLoS One. 2010
  PubMed ID: 20305777
   
  
• High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
  Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
  PLoS Genet. 2009
  PubMed ID: 19851445
   
  
• CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
  Beswick EJ, Reyes VE
  World J Gastroenterol. 2009
  PubMed ID: 19533806
   
  
• Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci.
  Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS, Wilson AG
  Arthritis Rheum. 2009
  PubMed ID: 19116923
   
  
• MHC class II transport at a glance.
  Berger AC, Roche PA
  J Cell Sci. 2009
  PubMed ID: 19092054
   
  
• Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
  Julià A, Ballina J, Cañete JD, Balsa A, Tornero-Molina J, Naranjo A, Alperi-López M, Erra A, Pascual-Salcedo D, Barceló P, Camps J, Marsal S
  Arthritis Rheum. 2008
  PubMed ID: 18668548
   
  
• MHC class II molecules on the move for successful antigen presentation.
  Rocha N, Neefjes J
  EMBO J. 2008
  PubMed ID: 18046453
   
  
• Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
  Qi Q, August A
  Sci STKE. 2007
  PubMed ID: 17652306
   
  
• Autophagy in MHC class II presentation: sampling from within.
  Menéndez-Benito V, Neefjes J
  Immunity. 2007
  PubMed ID: 17241953
   
  
• Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
  Palacios EH, Weiss A
  Oncogene. 2004
  PubMed ID: 15489916
   
  
• The DNA sequence and analysis of human chromosome 6.
  Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
  Nature. 2003
  PubMed ID: 14574404
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
  Williams MA, Trout R, Spector SA
  J Hematother Stem Cell Res. 2002
  PubMed ID: 12427289
   
  
• Adapters in lymphocyte signaling.
  Leo A, Wienands J, Baier G, Horejsi V, Schraven B
  J Clin Invest. 2002
  PubMed ID: 11827988
   
  
• Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
  Wang JH, Meijers R, Xiong Y, Liu JH, Sakihama T, Zhang R, Joachimiak A, Reinherz EL
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11535811
   
  
• Presentation of antigens by MHC class II molecules: getting the most out of them.
  Villadangos JA
  Mol Immunol. 2001
  PubMed ID: 11684289
   
  
• Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
  Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
  Biochem Biophys Res Commun. 2000
  PubMed ID: 11118314
   
  
• The mechanism of phospholipase C-gamma1 regulation.
  Kim MJ, Kim E, Ryu SH, Suh PG
  Exp Mol Med. 2000
  PubMed ID: 11048639
   
  
• Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
  Poon DT, Coren LV, Ott DE
  J Virol. 2000
  PubMed ID: 10729169
   
  
• Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
  Kanazawa S, Okamoto T, Peterlin BM
  Immunity. 2000
  PubMed ID: 10661406
   
  
• The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
  Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
  J Biol Chem. 1997
  PubMed ID: 9079699
   
  
• The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.
  Rudy GB, Lew AM
  J Immunol. 1997
  PubMed ID: 9036956
   
  
• Invariant chain structure and MHC class II function.
  Cresswell P
  Cell. 1996
  PubMed ID: 8598037
   
  
• HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
  Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
  J Immunol. 1995
  PubMed ID: 7541827
   
  
• Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
  Rowell JF, Stanhope PE, Siliciano RF
  J Immunol. 1995
  PubMed ID: 7602119
   
  
• HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
  Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP
  Mol Immunol. 1994
  PubMed ID: 8084338
   
  
• HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.
  Houlgatte R, Scarmato P, el Marhomy S, Martin M, Ostankovitch M, Lafosse S, Vervisch A, Auffray C, Platier-Tonneau D
  J Immunol. 1994
  PubMed ID: 7512597
   
  
• Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
  Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
  Cell Immunol. 1994
  PubMed ID: 8168144
   
  
• HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
  Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF
  J Immunol. 1993
  PubMed ID: 8376762
   
  
• HLA class II nucleotide sequences, 1992.
  Marsh SG, Bodmer JG
  Tissue Antigens. 1992
  PubMed ID: 1362295
   
  
• Evolutionary relationships among the primate Mhc-DQA1 and DQA2 alleles.
  Kenter M, Otting N, Anholts J, Leunissen J, Jonker M, Bontrop RE
  Immunogenetics. 1992
  PubMed ID: 1612647
   
  
• Interaction of CD4 with HLA class II antigens and HIV gp120.
  Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C
  Immunogenetics. 1991
  PubMed ID: 1869305
   
  
• Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
  Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ
  Proc Natl Acad Sci U S A. 1990
  PubMed ID: 1978941
   
  
• HIV-gp120 can block CD4-class II MHC-mediated adhesion.
  Rosenstein Y, Burakoff SJ, Herrmann SH
  J Immunol. 1990
  PubMed ID: 1967269
   
  
• Ancient roots for polymorphism at the HLA-DQ alpha locus in primates.
  Gyllensten UB, Erlich HA
  Proc Natl Acad Sci U S A. 1989
  PubMed ID: 2513578
   
  
• Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
  Clayton LK, Sieh M, Pious DA, Reinherz EL
  Nature. 1989
  PubMed ID: 2543930
   
  
• Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
  Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ
  J Immunol. 1988
  PubMed ID: 2846691
   
  
• Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.
  Jonsson AK, Hyldig-Nielsen JJ, Servenius B, Larhammar D, Andersson G, Jörgensen F, Peterson PA, Rask L
  J Biol Chem. 1987
  PubMed ID: 3036828
   
  
• Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector.
  Auffray C, Lillie JW, Korman AJ, Boss JM, Fréchin N, Guillemot F, Cooper J, Mulligan RC, Strominger JL
  Immunogenetics. 1987
  PubMed ID: 3610256
   
  
• AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.
  Andrieu JM, Even P, Venet A
  AIDS Res. 1986
  PubMed ID: 3489470
   
  
• Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
  Auffray C, Lillie JW, Arnot D, Grossberger D, Kappes D, Strominger JL
  Nature. 1984
  PubMed ID: 6584734
   
  
• Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.
  Trowsdale J, Lee J, Carey J, Grosveld F, Bodmer J, Bodmer W
  Proc Natl Acad Sci U S A. 1983
  PubMed ID: 6300884
   
  

Relevant resources:

Comment on this Page
Privacy Statement  |   Copyright, Warranty & Disclaimer  |   Contact Us
Copyright © 2001-2011, T1DBase | Version 4.8 | PMID:20937630
Printed on Fri February 10, 2012