HLA-DPB2

Summary from T1DBase Top Help

Gene Description:

major histocompatibility complex, class II, DP beta 2 (pseudogene); histocompatibility 2, P region beta locus

Synonyms:

Ia7, H-2I, H-2Pb, H2-Ab3, H2-Pb, HLA-DPB2, H2-Ab, DPbeta2, DPB2, HLA-DP2B, H-2Ab, Pb, DP2B

Orthologs:

Human HLA-DPB2 (pseudo), Mouse H2-Pb (protein-coding)

Sources

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr6:33080293..33096890 (16.60 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
			no data		no data	no data	no data	no data	no data	no data	no data	no data

Expression Legend

Tissue Expression Top Help

We do not have tissue expression data for this gene.

HaemAtlas Expression Top Help

No HaemAtlas Expression pattern available for this gene.

Interactions from T1DBase Top Help

Interactions: 0

Cross-Reference to Pathways and GO Terms Top Help

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: None available

Publications Top Help

Type 1 Diabetes Publications: 1

Publications: 22

Genome-wide association study identifies susceptibility loci for IgA nephropathy.
Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, Bodria M, Lugani F, Ravani P, Ponticelli C, Allegri L, Boscutti G, Frasca G, Amore A, Peruzzi L, Coppo R, Izzi C, Viola BF, Prati E, Salvadori M, Mignani R, Gesualdo L, Bertinetto F, Mesiano P, Amoroso A, Scolari F, Chen N, Zhang H, Lifton RP
Nat Genet. 2011
PubMed ID: 21399633
Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection.
Ucisik-Akkaya E, Davis CF, Do TN, Morrison BA, Stemmer SM, Amadio WJ, Tevfik Dorak M
Mol Hum Reprod. 2010
PubMed ID: 20587610
HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans.
Zhou X, Lee JE, Arnett FC, Xiong M, Park MY, Yoo YK, Shin ES, Reveille JD, Mayes MD, Kim JH, Song R, Choi JY, Park JA, Lee YJ, Lee EY, Song YW, Lee EB
Arthritis Rheum. 2009
PubMed ID: 19950302
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H, Witteman JC, Kääb S, Hicks AA, Gyllensten U, Rudan I, Meitinger T, Pattaro C, van Duijn CM, Wilson JF, Pramstaller PP, EUROSPAN Consortium
Circ Cardiovasc Genet. 2009
PubMed ID: 20031603
Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction.
Shiffman D, Kane JP, Louie JZ, Arellano AR, Ross DA, Catanese JJ, Malloy MJ, Ellis SG, Devlin JJ
PLoS ONE. 2008
PubMed ID: 18682748
Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5.
Abe K, Yuzuriha M, Sugimoto M, Ko MS, Brathwaite M, Waeltz P, Nagaraja R
Mamm Genome. 2004
PubMed ID: 15112104
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class II region.
Isobe T, Yoshino M, Mizuno K, Lindahl KF, Koide T, Gaudieri S, Gojobori T, Shiroishi T
Genomics. 2002
PubMed ID: 12160737
Sequence, linkage to H2-K, and function of mouse tapasin in MHC class I assembly.
Grandea AG, Comber PG, Wenderfer SE, Schoenhals G, Früh K, Monaco JJ, Spies T
Immunogenetics. 1998
PubMed ID: 9716645
Genetic mapping of 10 microsatellites in the t complex region of mouse chromosome 17.
Vernet C, Abe K, Artzt K
Mamm Genome. 1998
PubMed ID: 9585437
Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa.
Arimura Y, Koda T, Kishi M, Kakinuma M
Immunogenetics. 1996
PubMed ID: 8550099
No dosage effect of recombinational hotspots in the mouse major histocompatibility complex.
Yoshino M, Sagai T, Lindahl KF, Toyoda Y, Shiroishi T, Moriwaki K
Immunogenetics. 1994
PubMed ID: 7910587
The alpha 2(XI) collagen gene lies within 8 kb of Pb in the proximal portion of the murine major histocompatibility complex.
Stubbs L, Lui VC, Ng LJ, Cheah KS
Mamm Genome. 1993
PubMed ID: 8431643
Aberrant convergence of the neural folds in the mouse mutant vl.
Wilson DB, Wyatt DP
Teratology. 1992
PubMed ID: 1731393
Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene.
Martinez CK, Monaco JJ
Nature. 1991
PubMed ID: 1681432
A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.
Cho S, Attaya M, Brown MG, Monaco JJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1711220
Colinearity of novel genes in the class II regions of the MHC in mouse and human.
Hanson IM, Trowsdale J
Immunogenetics. 1991
PubMed ID: 1855816
Localization of a mouse heat shock Hsp70 gene within the H-2 complex.
Gaskins HR, Prochazka M, Nadeau JH, Henson VW, Leiter EH
Immunogenetics. 1990
PubMed ID: 1978715
Recombinational hotspot specific to female meiosis in the mouse major histocompatibility complex.
Shiroishi T, Hanzawa N, Sagai T, Ishiura M, Gojobori T, Steinmetz M, Moriwaki K
Immunogenetics. 1990
PubMed ID: 1968049
Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.
Gustafsson K, Widmark E, Jonsson AK, Servenius B, Sachs DH, Larhammar D, Rask L, Peterson PA
J Biol Chem. 1987
PubMed ID: 3036829
Gene organization and recombinational hotspots in the murine major histocompatibility complex.
Steinmetz M, Stephan D, Fischer Lindahl K
Cell. 1986
PubMed ID: 3754180
The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3.
Widera G, Flavell RA
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3860873

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:95926	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3116	15004	N/A
EnsEMBL Gene(s)	N/A	N/A	N/A
Unigene	Hs.665450	N/A	N/A
Homologene	HLA-DPB2	H2-Pb	N/A
OMIM	N/A	N/A	N/A
GeneCards	HLA-DPB2	N/A	N/A
Beta Cell Genomics	DT.40201220 DT.91878430	N/A	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:95926	N/A
WikiGenes	3116	15004	N/A

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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