HLA-DPA1

Summary from T1DBase Top Help

Gene Description:

histocompatibility 2, P region alpha locus; major histocompatibility complex, class II, DP alpha 1; RT1 class II, locus Ha

Synonyms:

HLA-DPA1, PLT1, HLADP, HLA-DP1A, DP(W4), MGC116352, RT1-Ha, RT1.Ha, HLASB, H2-Pa, DP(W3), H2-Pa-ps

Orthologs:

Human HLA-DPA1 (protein-coding), Mouse H2-Pa (pseudo), Rat RT1-Ha (protein-coding)

Sources

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr6:33032346..33048555 (16.21 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:4902015..4907767 (5.75 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
					no data	no data	no data	no data	no data	no data	no data	no data

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker	EB	MK	CD66b	CD14	CD19	CD8	CD4	CD56
Expression Pattern									HaemAtlasProfile

Expression Legend

Interactions from T1DBase Top Help

Interactions Table for HLA-DPA1:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 17

Biocarta: None available

Reactome: 7

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 17

Publications Top Help

Type 1 Diabetes Publications: 3

Publications: 108

A common HLA-DPA1 variant is a major determinant of hepatitis B virus clearance in Han Chinese.
An P, Winkler C, Guan L, O'Brien SJ, Zeng Z, HBV Study Consortium
J Infect Dis. 2011
PubMed ID: 21402545
Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population.
Guo X, Zhang Y, Li J, Ma J, Wei Z, Tan W, O'Brien SJ
Hepatology. 2011
PubMed ID: 21274863
Genome-wide association study identifies susceptibility loci for IgA nephropathy.
Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, Bodria M, Lugani F, Ravani P, Ponticelli C, Allegri L, Boscutti G, Frasca G, Amore A, Peruzzi L, Coppo R, Izzi C, Viola BF, Prati E, Salvadori M, Mignani R, Gesualdo L, Bertinetto F, Mesiano P, Amoroso A, Scolari F, Chen N, Zhang H, Lifton RP
Nat Genet. 2011
PubMed ID: 21399633
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Identification of HLA-DPA1*020107 in an individual of Ugandan descent.
Czarnecki C, Luo M, Brunham R, Broliden K, Karlsson AC, Plummer FA
Hum Immunol. 2010
PubMed ID: 20470845
[Analysis of the HLA-DPA1 and HLA-DPB1 polymorphism of Zhejiang Han population by PCR-sequence based typing]
Dai WJ, Zhu FM, Yan LX, Zhao HC
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010
PubMed ID: 20376809
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses.
Kennedy RB, Ovsyannikova IG, Vierkant RA, Jacobson RM, Poland GA
Hum Immunol. 2010
PubMed ID: 19896518
Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.
Ovsyannikova IG, Vierkant RA, Pankratz VS, Jacobson RM, Poland GA
PLoS One. 2010
PubMed ID: 20668555
HLA genotyping in the international Type 1 Diabetes Genetics Consortium.
Mychaleckyj JC, Noble JA, Moonsamy PV, Carlson JA, Varney MD, Post J, Helmberg W, Pierce JJ, Bonella P, Fear AL, Lavant E, Louey A, Boyle S, Lane JA, Sali P, Kim S, Rappner R, Williams DT, Perdue LH, Reboussin DM, Tait BD, Akolkar B, Hilner JE, Steffes MW, Erlich HA, T1DGC
Clin Trials. 2010
PubMed ID: 20595243
HLA Class I and II profiles in São Miguel Island (Azores): genetic diversity and linkage disequilibrium.
Pacheco PR, Branco CC, Gomes CT, Cabral R, Mota-Vieira L
BMC Res Notes. 2010
PubMed ID: 20462405
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
Malhotra A, Igo RP, Thameem F, Kao WH, Abboud HE, Adler SG, Arar NH, Bowden DW, Duggirala R, Freedman BI, Goddard KA, Ipp E, Iyengar SK, Kimmel PL, Knowler WC, Kohn O, Leehey D, Meoni LA, Nelson RG, Nicholas SB, Parekh RS, Rich SS, Chen YD, Saad MF, Scavini M, Schelling JR, Sedor JR, Shah VO, Taylor KD, Thornley-Brown D, Zager PG, Horvath A, Hanson RL, Family Investigation of Nephropathy and Diabetes Research Group
Diabetes Metab Res Rev. 2009
PubMed ID: 19795399
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS Genet. 2009
PubMed ID: 19851445
Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study.
Alves-Leon SV, Veluttini-Pimentel ML, Gouveia ME, Malfetano FR, Gaspareto EL, Alvarenga MP, Frugulhetti I, Quirico-Santos T
Arq Neuropsiquiatr. 2009
PubMed ID: 19722042
HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States.
Baxter-Lowe LA, Maiers M, Spellman SR, Haagenson MD, Wang T, Fernandez-Vina M, Marsh SG, Horowitz M, Hurley CK
Biol Blood Marrow Transplant. 2009
PubMed ID: 19589487
CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.
Beswick EJ, Reyes VE
World J Gastroenterol. 2009
PubMed ID: 19533806
HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine.
Ovsyannikova IG, Vierkant RA, Pankratz VS, O'Byrne MM, Jacobson RM, Poland GA
Vaccine. 2009
PubMed ID: 19200828
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.
Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N, Kubo M, Tsunoda T, Kamatani N, Kumada H, Puseenam A, Sura T, Daigo Y, Chayama K, Chantratita W, Nakamura Y, Matsuda K
Nat Genet. 2009
PubMed ID: 19349983
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes.
Baschal EE, Aly TA, Jasinski JM, Steck AK, Johnson KN, Noble JA, Erlich HA, Eisenbarth GS, Diabetes Genetics Consortium
Diabetes Obes Metab. 2009
PubMed ID: 19143812
MHC class II transport at a glance.
Berger AC, Roche PA
J Cell Sci. 2009
PubMed ID: 19092054
Identification of a novel DPA1 allele, DPA1*010602, in an East African population.
Peterson TA, Luo M, Mao X, Brunham RC, Plummer FA
Hum Immunol. 2008
PubMed ID: 18838095
A common human leucocyte antigen-DP genotype is associated with resistance to HIV-1 infection in Kenyan sex workers.
Hardie RA, Knight E, Bruneau B, Semeniuk C, Gill K, Nagelkerke N, Kimani J, Wachihi C, Ngugi E, Luo M, Plummer FA
AIDS. 2008
PubMed ID: 18784467
Studies on the compatibility of HLA-Class II alleles in patient couples with severe pre-eclampsia using PCR-RFLP methods.
Ooki I, Takakuwa K, Akashi M, Nonaka T, Yokoo T, Tanaka K
Am J Reprod Immunol. 2008
PubMed ID: 18593440
A novel HLA-DPA1*0204 allele was identified in a Chinese individual.
Zhao H, Dai WJ, He YM, Zhu FM, Yan LX
Tissue Antigens. 2008
PubMed ID: 18489436
Description of two novel HLA-DPA1 alleles: DPA1*0110 and DPA1*010304.
Lee KW
Tissue Antigens. 2008
PubMed ID: 18380777
MHC class II molecules on the move for successful antigen presentation.
Rocha N, Neefjes J
EMBO J. 2008
PubMed ID: 18046453
High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.
Lee SJ, Klein J, Haagenson M, Baxter-Lowe LA, Confer DL, Eapen M, Fernandez-Vina M, Flomenberg N, Horowitz M, Hurley CK, Noreen H, Oudshoorn M, Petersdorf E, Setterholm M, Spellman S, Weisdorf D, Williams TM, Anasetti C
Blood. 2007
PubMed ID: 17785583
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
Autophagy in MHC class II presentation: sampling from within.
Menéndez-Benito V, Neefjes J
Immunity. 2007
PubMed ID: 17241953
Human leukocyte antigen and interleukin 2, 10 and 12p40 cytokine responses to measles: is there evidence of the HLA effect?
Ovsyannikova IG, Ryan JE, Jacobson RM, Vierkant RA, Pankratz VS, Poland GA
Cytokine. 2006
PubMed ID: 17234427
Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality.
Liu W, Li WM, Yang SS, Gao C, Li SJ, Li Y, Kong YH, Gan RT
Autoimmunity. 2006
PubMed ID: 17060025
An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide.
Liu X, Fu Y, Liu Z, Lin B, Xie Y, Liu Y, Xu Y, Lin J, Fan X, Dong M, Zeng K, Wu CI, Xu A
Am J Hum Genet. 2006
PubMed ID: 16465617
Assembly of major histocompatibility complex class II subunits with invariant chain.
Neumann J, Koch N
FEBS Lett. 2005
PubMed ID: 16242130
[Studies on the association of human leukocyte antigen class II alleles with advanced hepatosplenic schistosomiasis japonica]
Zhang JH, Liu WQ, Li YL, Long XC
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing. 2005
PubMed ID: 16042197
HLA-DPA1 promoter haplotypes are differently distributed in southern Chinese ethnic groups.
Liu X, Xu Y, Shen Y, Zhang H, Fu Y, Liu Z, Xu A
Tissue Antigens. 2005
PubMed ID: 15713216
Identification of HLA-DRPhebeta47 as the susceptibility marker of hypersensitivity to beryllium in individuals lacking the berylliosis-associated supratypic marker HLA-DPGlubeta69.
Amicosante M, Berretta F, Rossman M, Butler RH, Rogliani P, van den Berg-Loonen E, Saltini C
Respir Res. 2005
PubMed ID: 16098233
High-resolution sequence-based DPA1 typing identified two novel DPA1 alleles, DPA1*010303 and DPA1*0303, from a Kenyan population.
Luo M, Bamforth J, Gill K, Cohen C, Brunham RC, Plummer FA
Tissue Antigens. 2005
PubMed ID: 15663751
HLA-DP polymorphism in Venezuelan Amerindians.
Gendzekhadze K, Herrera F, Montagnani S, Balbas O, Witter K, Albert E, Layrisse Z
Hum Immunol. 2004
PubMed ID: 15603877
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.
Flomenberg N, Baxter-Lowe LA, Confer D, Fernandez-Vina M, Filipovich A, Horowitz M, Hurley C, Kollman C, Anasetti C, Noreen H, Begovich A, Hildebrand W, Petersdorf E, Schmeckpeper B, Setterholm M, Trachtenberg E, Williams T, Yunis E, Weisdorf D
Blood. 2004
PubMed ID: 15191952
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S
Genome Res. 2004
PubMed ID: 15342556
Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain).
Pérez-Miranda AM, Alfonso-Sánchez MA, Vidales MC, Calderón R, Peña JA
Tissue Antigens. 2004
PubMed ID: 15304007
Associations between human leukocyte antigen (HLA) alleles and very high levels of measles antibody following vaccination.
Ovsyannikova IG, Jacobson RM, Vierkant RA, Shane Pankratz V, Jacobsen SJ, Poland GA
Vaccine. 2004
PubMed ID: 15121303
The genomic sequence and comparative analysis of the rat major histocompatibility complex.
Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
Genome Res. 2004
PubMed ID: 15060004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis.
Olivo-Díaz A, Debaz H, Alaez C, Islas VJ, Pérez-Pérez H, Hobart O, Gorodezky C
Hum Immunol. 2004
PubMed ID: 15041165
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.
Schaffer M, Aldener-Cannavá A, Remberger M, Ringdén O, Olerup O
Tissue Antigens. 2003
PubMed ID: 12956878
Sequence variability analysis of human class I and class II MHC molecules: functional and structural correlates of amino acid polymorphisms.
Reche PA, Reinherz EL
J Mol Biol. 2003
PubMed ID: 12899833
[Human leucocyte antigen-DPA1 polymorphism distribution in Chengdu Chinese families with intrahepatic cholestasis of pregnancy]
Zhang L, Liu S, Chen Q, Yang X, Chen X
Sichuan Da Xue Xue Bao Yi Xue Ban. 2003
PubMed ID: 12910711
[Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province]
Zhou JF, Guo SS, Yu P
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003
PubMed ID: 12778461
Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression.
Muczynski KA, Ekle DM, Coder DM, Anderson SK
J Am Soc Nephrol. 2003
PubMed ID: 12707403
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
Williams MA, Trout R, Spector SA
J Hematother Stem Cell Res. 2002
PubMed ID: 12427289
Investigation of HLA-DPA1 genotypes as predictors of inflammatory bowel disease in the German, South African, and South Korean populations.
Lantermann A, Hampe J, Kim WH, Winter TA, Kidd M, Nagy M, Fölsch UR, Schreiber S
Int J Colorectal Dis. 2002
PubMed ID: 12073072
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III.
Holling TM, van der Stoep N, Quinten E, van den Elsen PJ
J Immunol. 2002
PubMed ID: 11777970
The major histocompatibility complex of the rat (Rattus norvegicus).
Günther E, Walter L
Immunogenetics. 2001
PubMed ID: 11685465
Presentation of antigens by MHC class II molecules: getting the most out of them.
Villadangos JA
Mol Immunol. 2001
PubMed ID: 11684289
HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing.
Velickovic ZM, Carter JM
Tissue Antigens. 2001
PubMed ID: 11556979
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
Biochem Biophys Res Commun. 2000
PubMed ID: 11118314
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
A new HLA-DPA1 allele, DPA1*02016, identified in African-American population.
McDaniel DO, Nguyen C, McDaniel LS
Tissue Antigens. 2000
PubMed ID: 11019928
The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject.
McTernan CL, Mijovic CH, Cockram CS, Barnett AH
Tissue Antigens. 2000
PubMed ID: 10958363
Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
Poon DT, Coren LV, Ott DE
J Virol. 2000
PubMed ID: 10729169
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Kanazawa S, Okamoto T, Peterlin BM
Immunity. 2000
PubMed ID: 10661406
Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs.
Steiner LL, Wu J, Noreen HJ, Moehlenkamp C, Cavalli A, Davidson M, Johnson S, Winden T, Segall M, Begovich AB, Williams TM
Tissue Antigens. 1999
PubMed ID: 10090623
Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302.
Steiner LL, Cavalli A, Zimmerman PA, Boatin BA, Titanji VP, Bradley JE, Lucius R, Nutman TB, Begovich AB
Tissue Antigens. 1998
PubMed ID: 9694359
[The expression of human leukocyte antigen from peripheral blood of patients with herpetic keratitis]
Liu Z, Chen J, Li S, Zeng Y, Sun H
Yan Ke Xue Bao. 1998
PubMed ID: 12580031
HLA-DP2: self peptide sequences and binding properties.
Chicz RM, Graziano DF, Trucco M, Strominger JL, Gorga JC
J Immunol. 1997
PubMed ID: 9366419
A novel DPA1 allele (DPA1*0203) composed of known epitopes.
Muntau B, Thye T, Pirmez C, Horstmann RD
Tissue Antigens. 1997
PubMed ID: 9234495
The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
J Biol Chem. 1997
PubMed ID: 9079699
DPA1*0105, a novel DPA1 variant in a negroid population.
May J, Kretschmer C, Schnittger L, Striecker R, Kremsner PG, Meyer CG
Tissue Antigens. 1996
PubMed ID: 8988544
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Human thymic epithelial cells express functional HLA-DP molecules.
Jørgensen A, Röpke C, Nielsen M, Madsen H, Svejgaard A, Odum N
Tissue Antigens. 1996
PubMed ID: 8773319
Invariant chain structure and MHC class II function.
Cresswell P
Cell. 1996
PubMed ID: 8598037
A zinc finger protein that represses transcription of the human MHC class II gene, DPA.
Scholl T, Stevens MB, Mahanta S, Strominger JL
J Immunol. 1996
PubMed ID: 8568247
Selective association of a 22-38 kDa glycoprotein with MHC class II DP antigen on activated human lymphocytes at the plasma membrane.
Carra G, Giunta M, Benati C, Bovolenta C, Tridente G, Libonati M, Gerosa F
Mol Immunol. 1996
PubMed ID: 8649448
Mouse HLA-DPA homologue H2-Pa: a pseudogene that maps between H2-Pb and H2-Oa.
Arimura Y, Koda T, Kishi M, Kakinuma M
Immunogenetics. 1996
PubMed ID: 8550099
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
Rowell JF, Stanhope PE, Siliciano RF
J Immunol. 1995
PubMed ID: 7602119
Exon 2, 3, and 4 polymorphism of HLA-DPA1.
Rozemuller EH, Versluis LF, Bouwens AG, Tilanus MG
Immunogenetics. 1995
PubMed ID: 7806277
Sequencing-based typing reveals new insight in HLA-DPA1 polymorphism.
Rozemuller EH, Bouwens AG, van Oort E, Versluis LF, Marsh SG, Bodmer JG, Tilanus MG
Tissue Antigens. 1995
PubMed ID: 7725312
Structure of novel rat major histocompatibility complex class II genes RT1.Ha and Hb.
Arimura Y, Tang WR, Koda T, Kakinuma M
Immunogenetics. 1995
PubMed ID: 7721355
HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP
Mol Immunol. 1994
PubMed ID: 8084338
MHC class II and ICAM-1 expression and lymphocyte subsets in transbronchial biopsies from lung transplant recipients.
Milne DS, Gascoigne AD, Wilkes J, Sviland L, Ashcroft T, Malcolm AJ, Corris PA
Transplantation. 1994
PubMed ID: 7912458
HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.
Houlgatte R, Scarmato P, el Marhomy S, Martin M, Ostankovitch M, Lafosse S, Vervisch A, Auffray C, Platier-Tonneau D
J Immunol. 1994
PubMed ID: 7512597
Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
Cell Immunol. 1994
PubMed ID: 8168144
HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF
J Immunol. 1993
PubMed ID: 8376762
Identification of potent mixed leukocyte reaction-stimulatory cells in human bone marrow. Putative differentiation stage of human blood dendritic cells.
Egner W, McKenzie JL, Smith SM, Beard ME, Hart DN
J Immunol. 1993
PubMed ID: 8454872
Interaction of CD4 with HLA class II antigens and HIV gp120.
Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C
Immunogenetics. 1991
PubMed ID: 1869305
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ
Proc Natl Acad Sci U S A. 1990
PubMed ID: 1978941
HIV-gp120 can block CD4-class II MHC-mediated adhesion.
Rosenstein Y, Burakoff SJ, Herrmann SH
J Immunol. 1990
PubMed ID: 1967269
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
Clayton LK, Sieh M, Pious DA, Reinherz EL
Nature. 1989
PubMed ID: 2543930
T-cell response to purified protein derivative after removal of Langerhans' cells from epidermal cell suspensions containing keratinocytes expressing class II transplantation antigens.
Tjernlund U, Scheynius A, Johansson C, Hagforsen E, Nilsson H
Scand J Immunol. 1988
PubMed ID: 3266023
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ
J Immunol. 1988
PubMed ID: 2846691
Epitope recognition by a DP alpha chain-specific monoclonal antibody (DP11.1) is influenced by the interaction between the DP alpha chain and its polymorphic DP beta chain partner.
Young JA, Lindsay J, Bodmer JG, Trowsdale J
Hum Immunol. 1988
PubMed ID: 2461352
Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes.
Gustafsson K, Widmark E, Jonsson AK, Servenius B, Sachs DH, Larhammar D, Rask L, Peterson PA
J Biol Chem. 1987
PubMed ID: 3036829
AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.
Andrieu JM, Even P, Venet A
AIDS Res. 1986
PubMed ID: 3489470
The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene.
Lawrance SK, Das HK, Pan J, Weissman SM
Nucleic Acids Res. 1985
PubMed ID: 2997750
Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes.
Kelly A, Trowsdale J
Nucleic Acids Res. 1985
PubMed ID: 2987832
Functional expression of HLA-DP genes transfected into mouse fibroblasts.
Austin P, Trowsdale J, Rudd C, Bodmer W, Feldmann M, Lamb J
Nature. 1985
PubMed ID: 2578218
Isolation of a cDNA clone coding for an SB beta-chain.
Gustafsson K, Emmoth E, Widmark E, Böhme J, Peterson PA, Rask L
Nature. 1984
PubMed ID: 6325928
Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
Auffray C, Lillie JW, Arnot D, Grossberger D, Kappes D, Strominger JL
Nature. 1984
PubMed ID: 6584734
Sequences related to HLA-DR alpha chain on human chromosome 6: restriction enzyme polymorphism detected with DC alpha chain probes.
Trowsdale J, Lee J, Carey J, Grosveld F, Bodmer J, Bodmer W
Proc Natl Acad Sci U S A. 1983
PubMed ID: 6300884

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:105314	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3113	15003	24986
EnsEMBL Gene(s)	ENSG00000168384 ENSG00000206291 ENSG00000224103 ENSG00000228163 ENSG00000229685 ENSG00000231389 ENSG00000235844 ENSG00000236177	N/A	ENSRNOG00000026669
Unigene	Hs.347270	N/A	Rn.144557
Homologene	HLA-DPA1	H2-Pa	RT1-Ha
OMIM	142880	N/A	N/A
GeneCards	HLA-DPA1	N/A	N/A
Beta Cell Genomics	DT.121402866 DT.449635 DT.95202456	N/A	N/A
Reactome	P20036	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:105314	N/A
WikiGenes	3113	15003	24986

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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