HLA-DOB

Summary from T1DBase Top Help

Gene Description:

RT1 class II, locus DOb; major histocompatibility complex, class II, DO beta; histocompatibility 2, O region beta locus

Synonyms:

Ob, A-beta-2, RT1-DOb, H-2I, RT1-Bb2, H2-Ob, H-2Ob, H2-IAb2, HLA-DOB, FLJ57033, DOB, H2-Ab, H2-Ab2, A-beta2, H-2Ab

Orthologs:

Human HLA-DOB (protein-coding), Mouse H2-Ob (protein-coding), Rat RT1-DOb (protein-coding)

Sources

Regions of Interest Overlapping this feature from T1DBase Top Help

Regions Overlapping this Feature: Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd1	Mouse	chr17:34132973..35404440	1.27	98	6 no lod score

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr6:32780540..32784825 (4.29 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:34375848..34390850 (15 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:4753940..4759648 (5.71 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas
								no data	no data	no data	no data	no data

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

No HaemAtlas Expression pattern available for this gene.

Interactions from T1DBase Top Help

Interactions Table for HLA-DOB:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 17

Biocarta: None available

Reactome: 7

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 15

Publications Top Help

Type 1 Diabetes Publications: 2

Publications: 79

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS Genet. 2009
PubMed ID: 19851445
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
A flexible array format for large-scale, rapid blood group DNA typing.
Hashmi G, Shariff T, Seul M, Vissavajjhala P, Hue-Roye K, Charles-Pierre D, Lomas-Francis C, Chaudhuri A, Reid ME
Transfusion. 2005
PubMed ID: 15847654
Identification of a novel HLA-DOB-allele, DOB*010103, by sequence-based typing in the Korean population.
Gu H, Lee JK, Oh B
Tissue Antigens. 2005
PubMed ID: 15730525
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK
J Immunol. 2004
PubMed ID: 15265882
The genomic sequence and comparative analysis of the rat major histocompatibility complex.
Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
Genome Res. 2004
PubMed ID: 15060004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Downmodulation of antigen presentation by H2-O in B cell lines and primary B lymphocytes.
Brocke P, Armandola E, Garbi N, Hämmerling GJ
Eur J Immunol. 2003
PubMed ID: 12645938
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.
van Lith M, van Ham M, Neefjes J
Immunogenetics. 2002
PubMed ID: 12439622
HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
Williams MA, Trout R, Spector SA
J Hematother Stem Cell Res. 2002
PubMed ID: 12427289
The HLA-DOB gene displays limited polymorphism with only one amino acid substitution.
Naruse TK, Kawata H, Inoko H, Isshiki G, Yamano K, Hino M, Tatsumi N
Tissue Antigens. 2002
PubMed ID: 12445321
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Class II transactivator is required for maximal expression of HLA-DOB in B cells.
Nagarajan UM, Lochamy J, Chen X, Beresford GW, Nilsen R, Jensen PE, Boss JM
J Immunol. 2002
PubMed ID: 11823510
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
The major histocompatibility complex of the rat (Rattus norvegicus).
Günther E, Walter L
Immunogenetics. 2001
PubMed ID: 11685465
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
Biochem Biophys Res Commun. 2000
PubMed ID: 11118314
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
Poon DT, Coren LV, Ott DE
J Virol. 2000
PubMed ID: 10729169
Nonclassical MHC class II molecules.
Alfonso C, Karlsson L
Annu Rev Immunol. 2000
PubMed ID: 10837054
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Kanazawa S, Okamoto T, Peterlin BM
Immunity. 2000
PubMed ID: 10661406
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P
J Immunol. 1998
PubMed ID: 9759843
Genomic organization and cDNA sequence of the rat RT1-DOb gene.
Koda T, Kishi M, Kakinuma M, Tank WR
Immunogenetics. 1998
PubMed ID: 9601947
Altered antigen presentation in mice lacking H2-O.
Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP, Karlsson L
Immunity. 1998
PubMed ID: 9492004
Negative regulation by HLA-DO of MHC class II-restricted antigen processing.
Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P
Science. 1997
PubMed ID: 9311912
The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
J Biol Chem. 1997
PubMed ID: 9079699
HLA-DO is an intracellular class II molecule with distinctive thymic expression.
Douek DC, Altmann DM
Int Immunol. 1997
PubMed ID: 9088974
HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.
Liljedahl M, Kuwana T, Fung-Leung WP, Jackson MR, Peterson PA, Karlsson L
EMBO J. 1996
PubMed ID: 8890155
Identification of the transcription factors NF-YA and NF-YB as factors A and B that bound to the promoter of the major histocompatibility complex class II gene I-A beta.
Celada A, McKercher SR, Maki RA
Biochem J. 1996
PubMed ID: 8760361
Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development.
Georgiades P, Kieszkiewicz J, Rozycka M, Brickell PM, Lund T
Immunology. 1996
PubMed ID: 8774363
Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.
Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J
J Mol Biol. 1996
PubMed ID: 8568858
The sheep orthologue of the HLA-DOB gene.
Wright H, Redmond J, Ballingall KT
Immunogenetics. 1996
PubMed ID: 8537127
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
Rowell JF, Stanhope PE, Siliciano RF
J Immunol. 1995
PubMed ID: 7602119
HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP
Mol Immunol. 1994
PubMed ID: 8084338
Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis.
Brunsberg U, Gustafsson K, Jansson L, Michaëlsson E, Ahrlund-Richter L, Pettersson S, Mattsson R, Holmdahl R
Eur J Immunol. 1994
PubMed ID: 8026530
HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.
Houlgatte R, Scarmato P, el Marhomy S, Martin M, Ostankovitch M, Lafosse S, Vervisch A, Auffray C, Platier-Tonneau D
J Immunol. 1994
PubMed ID: 7512597
Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
Cell Immunol. 1994
PubMed ID: 8168144
HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF
J Immunol. 1993
PubMed ID: 8376762
The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing.
Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J
Eur J Immunol. 1993
PubMed ID: 8458375
DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing.
Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J
J Mol Biol. 1992
PubMed ID: 1453454
The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex.
Karlsson L, Peterson PA
J Exp Med. 1992
PubMed ID: 1354242
Aberrant convergence of the neural folds in the mouse mutant vl.
Wilson DB, Wyatt DP
Teratology. 1992
PubMed ID: 1731393
A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.
Cho S, Attaya M, Brown MG, Monaco JJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1711220
Interaction of CD4 with HLA class II antigens and HIV gp120.
Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C
Immunogenetics. 1991
PubMed ID: 1869305
Colinearity of novel genes in the class II regions of the MHC in mouse and human.
Hanson IM, Trowsdale J
Immunogenetics. 1991
PubMed ID: 1855816
Structure function analysis of the H-2 Abp gene.
Harton JA, Litaker W, Frelinger JA, Bishop GA
Immunogenetics. 1991
PubMed ID: 1748486
MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.
Deverson EV, Gow IR, Coadwell WJ, Monaco JJ, Butcher GW, Howard JC
Nature. 1990
PubMed ID: 1979660
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ
Proc Natl Acad Sci U S A. 1990
PubMed ID: 1978941
HIV-gp120 can block CD4-class II MHC-mediated adhesion.
Rosenstein Y, Burakoff SJ, Herrmann SH
J Immunol. 1990
PubMed ID: 1967269
Localization of a mouse heat shock Hsp70 gene within the H-2 complex.
Gaskins HR, Prochazka M, Nadeau JH, Henson VW, Leiter EH
Immunogenetics. 1990
PubMed ID: 1978715
Recombinational hotspot specific to female meiosis in the mouse major histocompatibility complex.
Shiroishi T, Hanzawa N, Sagai T, Ishiura M, Gojobori T, Steinmetz M, Moriwaki K
Immunogenetics. 1990
PubMed ID: 1968049
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
Clayton LK, Sieh M, Pious DA, Reinherz EL
Nature. 1989
PubMed ID: 2543930
Human class II DNA and DOB genes display low sequence variability.
Jonsson AK, Rask L
Immunogenetics. 1989
PubMed ID: 2499532
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ
J Immunol. 1988
PubMed ID: 2846691
Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.
Servenius B, Rask L, Peterson PA
J Biol Chem. 1987
PubMed ID: 3036827
Gene organization and recombinational hotspots in the murine major histocompatibility complex.
Steinmetz M, Stephan D, Fischer Lindahl K
Cell. 1986
PubMed ID: 3754180
AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.
Andrieu JM, Even P, Venet A
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PubMed ID: 3489470
Sequence of gene and cDNA encoding murine major histocompatibility complex class II gene A beta 2.
Larhammar D, Hammerling U, Rask L, Peterson PA
J Biol Chem. 1985
PubMed ID: 2997193
DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.
Tonnelle C, DeMars R, Long EO
EMBO J. 1985
PubMed ID: 2998758
The I region of the C57BL/10 mouse: characterization and physical linkage to H-2K of an SB beta-like class II pseudogene, psi A beta 3.
Widera G, Flavell RA
Proc Natl Acad Sci U S A. 1985
PubMed ID: 3860873
Isolation of a rat immune response gene identical to an alleged mouse a class II beta-chain pseudogene.
Schøller J, Lernmark A
Immunogenetics. 1985
PubMed ID: 3865893
Tracts of high or low sequence divergence in the mouse major histocompatibility complex.
Steinmetz M, Malissen M, Hood L, Orn A, Maki RA, Dastoornikoo GR, Stephan D, Gibb E, Romaniuk R
EMBO J. 1984
PubMed ID: 6098460
Structure of the murine immune response I-A beta locus: sequence of the I-A beta gene and an adjacent beta-chain second domain exon.
Larhammar D, Hammerling U, Denaro M, Lund T, Flavell RA, Rask L, Peterson PA
Cell. 1983
PubMed ID: 6411350
A molecular map of the immune response region from the major histocompatibility complex of the mouse.
Steinmetz M, Minard K, Horvath S, McNicholas J, Srelinger J, Wake C, Long E, Mach B, Hood L
Nature. 1982
PubMed ID: 6290895

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:95925	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3112	15002	365542
EnsEMBL Gene(s)	ENSG00000239457 ENSG00000241106 ENSG00000241386 ENSG00000241910 ENSG00000243496 ENSG00000243612	ENSMUSG00000041538	ENSRNOG00000000454
Unigene	Hs.1802	Mm.327358	Rn.215279
Homologene	HLA-DOB	H2-Ob	RT1-DOb
OMIM	600629	N/A	N/A
GeneCards	HLA-DOB	N/A	N/A
Beta Cell Genomics	DT.310888 DT.91742642	DT.101173253 DT.101332099 DT.490376 DT.55163696 DT.94167232 DT.97402210	N/A
Reactome	P13765	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:95925	N/A
WikiGenes	3112	15002	365542

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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