HLA-DMB

Summary from T1DBase Top Help

Gene Description:

histocompatibility 2, class II, locus Mb1; major histocompatibility complex, class II, DM beta; RT1 class II, locus DMb

Synonyms:

H2-DMb1, H-2Mb1, RT1.Mb, RT1-DMb, H2-Mb1, RING7, RT1.DMb, HLA-DMB, D6S221E, AI385589

Orthologs:

Human HLA-DMB (protein-coding), Mouse H2-DMb1 (protein-coding), Rat RT1-DMb (protein-coding)

Sources

Regions of Interest Overlapping this feature from T1DBase Top Help

Regions Overlapping this Feature: Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd1	Mouse	chr17:34132973..35404440	1.27	98	6 no lod score

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr6:32902406..32908847 (6.44 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:34282361..34297174 (14.81 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:4829535..4836772 (7.24 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker	EB	MK	CD66b	CD14	CD19	CD8	CD4	CD56
Expression Pattern									HaemAtlasProfile

Expression Legend

Interactions from T1DBase Top Help

Interactions Table for HLA-DMB:

The HLA-DMB interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
HLA-DMB	HLA-DMA	HPRD, MINT, IntAct, Reactome	empirical	8574855 8139690 9768757 21131964
HLA-DMB	HLA-DOB	HPRD	empirical	9311912
HLA-DMB	HLA-DRA	HPRD, BioGRID	empirical	8920889 9371817 12932352 7648393 10716924 8574855
HLA-DMB	HLA-DRB4	IntAct	empirical	21131964
HLA-DMB	CD82	HPRD, BioGRID	empirical	9759843
HLA-DMB	DPM2	HPRD	empirical	11591653
HLA-DMB	CD63	HPRD, BioGRID	empirical	9759843
HLA-DMB	CD74	HPRD	empirical	8574855

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 17

Biocarta: None available

Reactome: 7

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 12

Publications Top Help

Type 1 Diabetes Publications: 2

Publications: 110

Forced expression of HLA-DM at the surface of dendritic cells increases loading of synthetic peptides on MHC class II molecules and modulates T cell responses.
Pezeshki AM, Côté MH, Azar GA, Routy JP, Boulassel MR, Thibodeau J
J Immunol. 2011
PubMed ID: 21622867
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
Rinderknecht CH, Roh S, Pashine A, Belmares MP, Patil NS, Lu N, Truong P, Hou T, Macaubas C, Yoon T, Wang N, Busch R, Mellins ED
Immunology. 2010
PubMed ID: 20408893
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Cutting edge: HLA-DM-mediated peptide exchange functions normally on MHC class II-peptide complexes that have been weakened by elimination of a conserved hydrogen bond.
Ferrante A, Gorski J
J Immunol. 2010
PubMed ID: 20038641
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS Genet. 2009
PubMed ID: 19851445
Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.
Zhou Z, Callaway KA, Weber DA, Jensen PE
J Immunol. 2009
PubMed ID: 19767569
Complementary DNA sequences encoding the multimammate rat MHC class II DQ alpha and beta chains and cross-species sequence comparison in rodents.
de Bellocq JG, Leirs H
Tissue Antigens. 2009
PubMed ID: 19691639
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer.
Callahan MJ, Nagymanyoki Z, Bonome T, Johnson ME, Litkouhi B, Sullivan EH, Hirsch MS, Matulonis UA, Liu J, Birrer MJ, Berkowitz RS, Mok SC
Clin Cancer Res. 2008
PubMed ID: 19047092
[HLA-DM polymorphisms in Guizhou Han individuals]
Jiang HM, Wang YX, Wang Y
Yi Chuan. 2008
PubMed ID: 18779172
HLA-DM negatively regulates HLA-DR4-restricted collagen pathogenic peptide presentation and T cell recognition.
Amria S, Hajiaghamohseni LM, Harbeson C, Zhao D, Goldstein O, Blum JS, Haque A
Eur J Immunol. 2008
PubMed ID: 18506881
HLA-DM polymorphism and risk of trichloroethylene induced medicamentosa-like dermatitis.
Yue F, Huang HL, Huang JX, Liang LY, Huang ZL, Wei QY, Chen XM
Biomed Environ Sci. 2007
PubMed ID: 18348411
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
The DMalpha and DMbeta chain cooperate in the oxidation and folding of HLA-DM.
van Lith M, Benham AM
J Immunol. 2006
PubMed ID: 17015729
[HLA-DM gene polymorphism in Cantonese with condyloma acuminata]
Yang WL, Yang J, Chen SQ, Xie FY, Huang XY, Ye T
Nan Fang Yi Ke Da Xue Xue Bao. 2006
PubMed ID: 16864101
[Relationship of trichloroethylene-induced medicamentosa like dermatitis to HLA-DMA and HLA-DMB]
Yue F, Huang HL, Huang ZL, Li LY, Liang LY, Chen XM
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006
PubMed ID: 16737583
Small molecules that enhance the catalytic efficiency of HLA-DM.
Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW
J Immunol. 2006
PubMed ID: 16547258
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD
J Proteome Res. 2005
PubMed ID: 16335952
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Identification of a novel HLA-DMB allele (DMB*0107) in the Korean population.
Gu H, Moon SM, Kim JJ, Ryu HJ, Kwack K, Kimm K, Lee JK, Oh B
Tissue Antigens. 2005
PubMed ID: 15787724
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Association of HLA-DM polymorphism with the production of antiphospholipid antibodies.
Sanchez ML, Katsumata K, Atsumi T, Romero FI, Bertolaccini ML, Funke A, Amengual O, Kondeatis E, Vaughan RW, Cox A, Hughes GR, Khamashta MA
Ann Rheum Dis. 2004
PubMed ID: 15547089
HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis.
Morel J, Roch-Bras F, Molinari N, Sany J, Eliaou JF, Combe B
Ann Rheum Dis. 2004
PubMed ID: 15547082
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
The genomic sequence and comparative analysis of the rat major histocompatibility complex.
Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
Genome Res. 2004
PubMed ID: 15060004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
The DNA sequence and analysis of human chromosome 6.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S
Nature. 2003
PubMed ID: 14574404
Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides.
Pashine A, Busch R, Belmares MP, Munning JN, Doebele RC, Buckingham M, Nolan GP, Mellins ED
Immunity. 2003
PubMed ID: 12932352
Polymorphism of HLA-DMA and DMB alleles in patients with systemic lupus erythematosus.
Morel J, Simoes Cda S, Avinens O, Sany J, Combe B, Eliaou JF
J Rheumatol. 2003
PubMed ID: 12858445
Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination.
Dhiman N, Ovsyannikova IG, Pinsky NA, Vierkant RA, Jacobsen SJ, Jacobson RM, Poland GA
Eur J Immunogenet. 2003
PubMed ID: 12786997
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies.
Wiendl H, Lautwein A, Mitsdörffer M, Krause S, Erfurth S, Wienhold W, Morgalla M, Weber E, Overkleeft HS, Lochmüller H, Melms A, Tolosa E, Driessen C
J Neuroimmunol. 2003
PubMed ID: 12742663
Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO.
Chalouni C, Banchereau J, Vogt AB, Pascual V, Davoust J
Int Immunol. 2003
PubMed ID: 12663675
Association of TAP and HLA-DM genes with psoriasis in Koreans.
Pyo CW, Hur SS, Kim YK, Kim TY, Kim TG
J Invest Dermatol. 2003
PubMed ID: 12648225
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules.
Byrne B, Madrigal-Estebas L, McEvoy A, Carton J, Doherty DG, Whelan A, Feighery C, O'Donoghue DP, O'Farrelly C
Hum Immunol. 2002
PubMed ID: 12392850
HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
Williams MA, Trout R, Spector SA
J Hematother Stem Cell Res. 2002
PubMed ID: 12427289
Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.
Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L, Jensen PE
J Exp Med. 2002
PubMed ID: 11956296
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes.
Kropshofer H, Spindeldreher S, Röhn TA, Platania N, Grygar C, Daniel N, Wölpl A, Langen H, Horejsi V, Vogt AB
Nat Immunol. 2002
PubMed ID: 11743588
HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.
Moxley G, Han J
Eur J Immunogenet. 2001
PubMed ID: 11881821
Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome Res. 2001
PubMed ID: 11591653
The major histocompatibility complex of the rat (Rattus norvegicus).
Günther E, Walter L
Immunogenetics. 2001
PubMed ID: 11685465
Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.
van Lith M, van Ham M, Griekspoor A, Tjin E, Verwoerd D, Calafat J, Janssen H, Reits E, Pastoors L, Neefjes J
J Immunol. 2001
PubMed ID: 11441095
H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
Walter W, Scheuer C, Loos M, Reichert TE, Maeurer MJ
J Biol Chem. 2001
PubMed ID: 11148202
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium.
Muczynski KA, Cotner T, Anderson SK
Kidney Int. 2001
PubMed ID: 11168931
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
Biochem Biophys Res Commun. 2000
PubMed ID: 11118314
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
Walter W, Lingnau K, Schmitt E, Loos M, Maeurer MJ
Br J Cancer. 2000
PubMed ID: 11027433
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
The nucleotide sequence of a new DMB allele, DMB*0106.
McTernan CL, Mijovic CH, Cockram CS, Barnett AH
Tissue Antigens. 2000
PubMed ID: 10885572
Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese.
Zhu X, Zhang Y, Wang Q, Wang F
Chin Med J (Engl). 2000
PubMed ID: 11775239
Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
Poon DT, Coren LV, Ott DE
J Virol. 2000
PubMed ID: 10729169
Functional HLA-DM on the surface of B cells and immature dendritic cells.
Arndt SO, Vogt AB, Markovic-Plese S, Martin R, Moldenhauer G, Wölpl A, Sun Y, Schadendorf D, Hämmerling GJ, Kropshofer H
EMBO J. 2000
PubMed ID: 10716924
Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Kanazawa S, Okamoto T, Peterlin BM
Immunity. 2000
PubMed ID: 10661406
The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules.
Kropshofer H, Hämmerling GJ, Vogt AB
Immunol Rev. 1999
PubMed ID: 10631952
Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.
O'Riordan M, Grosschedl R
Immunity. 1999
PubMed ID: 10435576
HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases.
Yen JH, Tsai WC, Tsai JJ, Chen CJ, Lin CH, Ou TT, Wu CC, Liu HW
Kaohsiung J Med Sci. 1999
PubMed ID: 10375868
HLA-DM - an endosomal and lysosomal chaperone for the immune system.
Vogt AB, Kropshofer H
Trends Biochem Sci. 1999
PubMed ID: 10322421
HLA-DMB expression by thyrocytes: indication of the antigen-processing and possible presenting capability of thyroid cells.
Wu Z, Biro PA, Mirakian R, Hammond L, Curcio F, Ambesi-Impiombato FS, Bottazzo GF
Clin Exp Immunol. 1999
PubMed ID: 10209506
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cells.
Andersson T, Patwardhan A, Emilson A, Carlsson K, Scheynius A
Arch Dermatol Res. 1998
PubMed ID: 9879837
The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P
J Immunol. 1998
PubMed ID: 9759843
The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
Mosyak L, Zaller DM, Wiley DC
Immunity. 1998
PubMed ID: 9768757
Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function.
Busch R, Doebele RC, von Scheven E, Fahrni J, Mellins ED
J Immunol. 1998
PubMed ID: 9551909
Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.
Ullrich HJ, Döring K, Grüneberg U, Jähnig F, Trowsdale J, van Ham SM
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9371817
Negative regulation by HLA-DO of MHC class II-restricted antigen processing.
Denzin LK, Sant'Angelo DB, Hammond C, Surman MJ, Cresswell P
Science. 1997
PubMed ID: 9311912
The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
J Biol Chem. 1997
PubMed ID: 9079699
Editing of the HLA-DR-peptide repertoire by HLA-DM.
Kropshofer H, Vogt AB, Moldenhauer G, Hammer J, Blum JS, Hämmerling GJ
EMBO J. 1996
PubMed ID: 8947036
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.
van Ham SM, Grüneberg U, Malcherek G, Bröker I, Melms A, Trowsdale J
J Exp Med. 1996
PubMed ID: 8920889
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
Weber DA, Evavold BD, Jensen PE
Science. 1996
PubMed ID: 8849454
HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.
Liljedahl M, Kuwana T, Fung-Leung WP, Jackson MR, Peterson PA, Karlsson L
EMBO J. 1996
PubMed ID: 8890155
Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB.
Copier J, Kleijmeer MJ, Ponnambalam S, Oorschot V, Potter P, Trowsdale J, Kelly A
J Immunol. 1996
PubMed ID: 8757605
Coexpression of H2-Mb and H2-Ab genes during fetal and postnatal development.
Georgiades P, Kieszkiewicz J, Rozycka M, Brickell PM, Lund T
Immunology. 1996
PubMed ID: 8774363
Three HLA-DMB variants in Korean patients with autoimmune diseases.
Kim TG, Carrington M, Choi HB, Kim HY, Han H
Hum Immunol. 1996
PubMed ID: 9157091
Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.
Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J
J Mol Biol. 1996
PubMed ID: 8568858
H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.
Walter W, Loos M, Maeurer MJ
Immunogenetics. 1996
PubMed ID: 8613139
Genomic organization of a mouse MHC class II region including the H2-M and Lmp2 loci.
Péléraux A, Karlsson L, Chambers J, Peterson PA
Immunogenetics. 1996
PubMed ID: 8575819
Association between HLA-DM and HLA-DR in vivo.
Sanderson F, Thomas C, Neefjes J, Trowsdale J
Immunity. 1996
PubMed ID: 8574855
The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif.
Lindstedt R, Liljedahl M, Péléraux A, Peterson PA, Karlsson L
Immunity. 1995
PubMed ID: 7584146
DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide.
Sherman MA, Weber DA, Jensen PE
Immunity. 1995
PubMed ID: 7648393
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
Rowell JF, Stanhope PE, Siliciano RF
J Immunol. 1995
PubMed ID: 7602119
Characterization of polymorphism within the H2-M MHC class II loci.
Hermel E, Yuan J, Monaco JJ
Immunogenetics. 1995
PubMed ID: 7607704
RT1.DMa and RT1.DMb: the rat homologues of H2-DMa and H2-DMb.
Hermel E, Monaco JJ
Immunogenetics. 1995
PubMed ID: 7590989
Analysis of HLA-DMB mutants and -DMB genomic structure.
Shaman J, von Scheven E, Morris P, Chang MD, Mellins E
Immunogenetics. 1995
PubMed ID: 7528727
HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP
Mol Immunol. 1994
PubMed ID: 8084338
Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.
Radley E, Alderton RP, Kelly A, Trowsdale J, Beck S
J Biol Chem. 1994
PubMed ID: 8034636
HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.
Houlgatte R, Scarmato P, el Marhomy S, Martin M, Ostankovitch M, Lafosse S, Vervisch A, Auffray C, Platier-Tonneau D
J Immunol. 1994
PubMed ID: 7512597
Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
Cell Immunol. 1994
PubMed ID: 8168144
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.
Fling SP, Arp B, Pious D
Nature. 1994
PubMed ID: 8139690
Limited polymorphism in HLA-DM does not involve the peptide binding groove.
Sanderson F, Powis SH, Kelly AP, Trowsdale J
Immunogenetics. 1994
PubMed ID: 8225438
HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF
J Immunol. 1993
PubMed ID: 8376762
Characterization of HLA-DMB polymorphism.
Carrington M, Yeager M, Mann D
Immunogenetics. 1993
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New class II-like genes in the murine MHC.
Cho SG, Attaya M, Monaco JJ
Nature. 1991
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A new human HLA class II-related locus, DM.
Kelly AP, Monaco JJ, Cho SG, Trowsdale J
Nature. 1991
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A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.
Cho S, Attaya M, Brown MG, Monaco JJ
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Interaction of CD4 with HLA class II antigens and HIV gp120.
Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C
Immunogenetics. 1991
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Colinearity of novel genes in the class II regions of the MHC in mouse and human.
Hanson IM, Trowsdale J
Immunogenetics. 1991
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Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
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Proc Natl Acad Sci U S A. 1990
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HIV-gp120 can block CD4-class II MHC-mediated adhesion.
Rosenstein Y, Burakoff SJ, Herrmann SH
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Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
Clayton LK, Sieh M, Pious DA, Reinherz EL
Nature. 1989
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Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
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AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.
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Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:95922	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3109	14999	294273
EnsEMBL Gene(s)	ENSG00000226264 ENSG00000234154 ENSG00000239329 ENSG00000241296 ENSG00000241674 ENSG00000242092 ENSG00000242386 ENSG00000242574	ENSMUSG00000079547	ENSRNOG00000027144
Unigene	Hs.351279	Mm.460938	Rn.5892
Homologene	HLA-DMB	H2-DMb1	RT1-DMb
OMIM	142856	N/A	N/A
GeneCards	HLA-DMB	N/A	N/A
Beta Cell Genomics	DT.100641850 DT.214633 DT.86854291 DT.95170296 DT.95190417 DT.95282617	DT.487016	N/A
Reactome	P28068	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:95922	N/A
WikiGenes	3109	14999	294273

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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