HLA-DMA

Summary from T1DBase Top Help

Gene Description:

major histocompatibility complex, class II, DM alpha; RT1 class II, locus DMa; histocompatibility 2, class II, locus DMa

Synonyms:

HLADM, H-2Ma, RT1.DMa, H2-DMa, RING6, H2-Ma, HLA-DMA, RT1-DMa, DMA, D6S222E, RT1.Ma

Orthologs:

Human HLA-DMA (protein-coding), Mouse H2-DMa (protein-coding), Rat RT1-DMa (protein-coding)

Sources

Regions of Interest Overlapping this feature from T1DBase Top Help

Regions Overlapping this Feature: Human: 1 Mouse: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
MHC	Human	chr6:29910021..33498585	3.59	688

Linkage Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd1	Mouse	chr17:34132973..35404440	1.27	98	6 no lod score

Gene Overview from T1DBase Top Help

(Human) GRCh37 - chr6:32916390..32938493 (22.10 kb) View in Genome Browser

(Mouse) NCBIM37 - chr17:34259777..34276046 (16.27 kb) View in Genome Browser

(Rat) RGSC3.4 - chr20:4843458..4846861 (3.40 kb) View in Genome Browser

Beta Cell Gene Atlas from T1DBase Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression Top Help

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

HaemAtlas Expression Top Help

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker	EB	MK	CD66b	CD14	CD19	CD8	CD4	CD56
Expression Pattern									HaemAtlasProfile

Expression Legend

Interactions from T1DBase Top Help

Interactions Table for HLA-DMA:

The HLA-DMA interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.

The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.

Interactor	Interactor	Sources	Classification	Pubmed IDs
HLA-DMA	HLA-DMB	HPRD, MINT, IntAct, Reactome	empirical	8574855 8139690 9768757 21131964
HLA-DMA	HLA-DOA	HPRD	empirical	9311912
HLA-DMA	HLA-DRA	HPRD, IntAct	empirical	9371817 8574855 11070170 21131964
HLA-DMA	HLA-DRB1	HPRD, IntAct, BioGRID	empirical	11070170 21131964 9371817
HLA-DMA	HLA-DRB4	IntAct	empirical	21131964
HLA-DMA	CD82	HPRD	empirical	9759843
HLA-DMA	MBP	IntAct	empirical	21131964
HLA-DMA	CD74	HPRD, IntAct	empirical	8574855 21131964

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 17

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 20

Publications Top Help

Type 1 Diabetes Publications: 1

Publications: 166

Human leukocyte antigen class II transgenic mouse model unmasks the significant extrahepatic pathology in toxic shock syndrome.
Tilahun AY, Marietta EV, Wu TT, Patel R, David CS, Rajagopalan G
Am J Pathol. 2011
PubMed ID: 21641398
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Negative selection and peptide chemistry determine the size of naive foreign peptide-MHC class II-specific CD4+ T cell populations.
Chu HH, Moon JJ, Kruse AC, Pepper M, Jenkins MK
J Immunol. 2010
PubMed ID: 20861357
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.
Rinderknecht CH, Roh S, Pashine A, Belmares MP, Patil NS, Lu N, Truong P, Hou T, Macaubas C, Yoon T, Wang N, Busch R, Mellins ED
Immunology. 2010
PubMed ID: 20408893
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
The activation threshold of CD4+ T cells is defined by TCR/peptide-MHC class II interactions in the thymic medulla.
Stephen TL, Tikhonova A, Riberdy JM, Laufer TM
J Immunol. 2009
PubMed ID: 19843939
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA
PLoS Genet. 2009
PubMed ID: 19851445
Complementary DNA sequences encoding the multimammate rat MHC class II DQ alpha and beta chains and cross-species sequence comparison in rodents.
de Bellocq JG, Leirs H
Tissue Antigens. 2009
PubMed ID: 19691639
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Type I Streptococcus pneumoniae carbohydrate utilizes a nitric oxide and MHC II-dependent pathway for antigen presentation.
Velez CD, Lewis CJ, Kasper DL, Cobb BA
Immunology. 2009
PubMed ID: 18778282
Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM.
Kamala T, Nanda NK
J Immunol. 2009
PubMed ID: 19342667
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, Therwath A, Schächter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF, ANRS Genomic Group
J Infect Dis. 2009
PubMed ID: 19115949
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Nepal RM, Vesosky B, Turner J, Bryant P
J Leukoc Biol. 2008
PubMed ID: 18591414
[HLA-DM polymorphisms in Guizhou Han individuals]
Jiang HM, Wang YX, Wang Y
Yi Chuan. 2008
PubMed ID: 18779172
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice.
Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ
J Immunol. 2008
PubMed ID: 18209058
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice.
Matynia A, Anagnostaras SG, Wiltgen BJ, Lacuesta M, Fanselow MS, Silva AJ
PLoS ONE. 2008
PubMed ID: 18464936
HLA-DM polymorphism and risk of trichloroethylene induced medicamentosa-like dermatitis.
Yue F, Huang HL, Huang JX, Liang LY, Huang ZL, Wei QY, Chen XM
Biomed Environ Sci. 2007
PubMed ID: 18348411
Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.
Qi Q, August A
Sci STKE. 2007
PubMed ID: 17652306
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells.
Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C
J Immunol. 2007
PubMed ID: 17513752
B cell-mediated antigen presentation is required for the pathogenesis of acute cardiac allograft rejection.
Noorchashm H, Reed AJ, Rostami SY, Mozaffari R, Zekavat G, Koeberlein B, Caton AJ, Naji A
J Immunol. 2006
PubMed ID: 17114442
The DMalpha and DMbeta chain cooperate in the oxidation and folding of HLA-DM.
van Lith M, Benham AM
J Immunol. 2006
PubMed ID: 17015729
[HLA-DM gene polymorphism in Cantonese with condyloma acuminata]
Yang WL, Yang J, Chen SQ, Xie FY, Huang XY, Ye T
Nan Fang Yi Ke Da Xue Xue Bao. 2006
PubMed ID: 16864101
[Relationship of trichloroethylene-induced medicamentosa like dermatitis to HLA-DMA and HLA-DMB]
Yue F, Huang HL, Huang ZL, Li LY, Liang LY, Chen XM
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006
PubMed ID: 16737583
Small molecules that enhance the catalytic efficiency of HLA-DM.
Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW
J Immunol. 2006
PubMed ID: 16547258
Amino-terminal flanking residues determine the conformation of a peptide-class II MHC complex.
Lovitch SB, Pu Z, Unanue ER
J Immunol. 2006
PubMed ID: 16493054
Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.
Belov K, Deakin JE, Papenfuss AT, Baker ML, Melman SD, Siddle HV, Gouin N, Goode DL, Sargeant TJ, Robinson MD, Wakefield MJ, Mahony S, Cross JG, Benos PV, Samollow PB, Speed TP, Graves JA, Miller RD
PLoS Biol. 2006
PubMed ID: 16435885
DM peptide-editing function leads to immunodominance in CD4 T cell responses in vivo.
Nanda NK, Bikoff EK
J Immunol. 2005
PubMed ID: 16272301
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Restricted MHC-peptide repertoire predisposes to autoimmunity.
Logunova NN, Viret C, Pobezinsky LA, Miller SA, Kazansky DB, Sundberg JP, Chervonsky AV
J Exp Med. 2005
PubMed ID: 15998789
Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.
Zwart W, Griekspoor A, Kuijl C, Marsman M, van Rheenen J, Janssen H, Calafat J, van Ham M, Janssen L, van Lith M, Jalink K, Neefjes J
Immunity. 2005
PubMed ID: 15723810
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
Association of HLA-DM polymorphism with the production of antiphospholipid antibodies.
Sanchez ML, Katsumata K, Atsumi T, Romero FI, Bertolaccini ML, Funke A, Amengual O, Kondeatis E, Vaughan RW, Cox A, Hughes GR, Khamashta MA
Ann Rheum Dis. 2004
PubMed ID: 15547089
HLA-DMA*0103 and HLA-DMB*0104 alleles as novel prognostic factors in rheumatoid arthritis.
Morel J, Roch-Bras F, Molinari N, Sany J, Eliaou JF, Combe B
Ann Rheum Dis. 2004
PubMed ID: 15547082
Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Palacios EH, Weiss A
Oncogene. 2004
PubMed ID: 15489916
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.
Fallas JL, Tobin HM, Lou O, Guo D, Sant'Angelo DB, Denzin LK
J Immunol. 2004
PubMed ID: 15265882
The genomic sequence and comparative analysis of the rat major histocompatibility complex.
Hurt P, Walter L, Sudbrak R, Klages S, Müller I, Shiina T, Inoko H, Lehrach H, Günther E, Reinhardt R, Himmelbauer H
Genome Res. 2004
PubMed ID: 15060004
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Effect of decreasing the affinity of the class II-associated invariant chain peptide on the MHC class II peptide repertoire in the presence or absence of H-2M.
Honey K, Forbush K, Jensen PE, Rudensky AY
J Immunol. 2004
PubMed ID: 15034026
Mechanisms governing B cell developmental defects in invariant chain-deficient mice.
Benlagha K, Park SH, Guinamard R, Forestier C, Karlsson L, Chang CH, Bendelac A
J Immunol. 2004
PubMed ID: 14764672
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
The DNA sequence and analysis of human chromosome 6.
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Nature. 2003
PubMed ID: 14574404
Regulation of the class II MHC pathway in primary human monocytes by granulocyte-macrophage colony-stimulating factor.
Hornell TM, Beresford GW, Bushey A, Boss JM, Mellins ED
J Immunol. 2003
PubMed ID: 12928384
Analysis of H2-O influence on antigen presentation by B cells.
Alfonso C, Williams GS, Han JO, Westberg JA, Winqvist O, Karlsson L
J Immunol. 2003
PubMed ID: 12928379
Expression and function of HLA-DR3 and DQ8 in transgenic mice lacking functional H2-M.
Rajagopalan G, Smart MK, Cheng S, Krco CJ, Johnson KL, David CS
Tissue Antigens. 2003
PubMed ID: 12889995
H2-O influence on antigen presentation in H2-E-expressing mice.
Alfonso C, Williams GS, Karlsson L
Eur J Immunol. 2003
PubMed ID: 12884868
Polymorphism of HLA-DMA and DMB alleles in patients with systemic lupus erythematosus.
Morel J, Simoes Cda S, Avinens O, Sany J, Combe B, Eliaou JF
J Rheumatol. 2003
PubMed ID: 12858445
The complexity of HLA class II (DRB1, DQB1, DM) associations with disseminated Mycobacterium avium complex infection among HIV-1-seropositive whites.
Naik E, LeBlanc S, Tang J, Jacobson LP, Kaslow RA
J Acquir Immune Defic Syndr. 2003
PubMed ID: 12794545
Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination.
Dhiman N, Ovsyannikova IG, Pinsky NA, Vierkant RA, Jacobsen SJ, Jacobson RM, Poland GA
Eur J Immunogenet. 2003
PubMed ID: 12786997
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies.
Wiendl H, Lautwein A, Mitsdörffer M, Krause S, Erfurth S, Wienhold W, Morgalla M, Weber E, Overkleeft HS, Lochmüller H, Melms A, Tolosa E, Driessen C
J Neuroimmunol. 2003
PubMed ID: 12742663
Increased expression of intracellular HLA-DM but not on the surface of blood monocyte-derived dendritic cells during maturation.
Kang JM, Chung HG, Oh SJ, Song SY, Lee TH, Lee MG
Yonsei Med J. 2003
PubMed ID: 12728471
Human germinal center B cells differ from naive and memory B cells by their aggregated MHC class II-rich compartments lacking HLA-DO.
Chalouni C, Banchereau J, Vogt AB, Pascual V, Davoust J
Int Immunol. 2003
PubMed ID: 12663675
Association of TAP and HLA-DM genes with psoriasis in Koreans.
Pyo CW, Hur SS, Kim YK, Kim TY, Kim TG
J Invest Dermatol. 2003
PubMed ID: 12648225
DM loss in k haplotype mice reveals isotype-specific chaperone requirements.
Koonce CH, Wutz G, Robertson EJ, Vogt AB, Kropshofer H, Bikoff EK
J Immunol. 2003
PubMed ID: 12646641
Antigen presentation by keratinocytes directs autoimmune skin disease.
Fan L, Busser BW, Lifsted TQ, Oukka M, Lo D, Laufer TM
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12629221
MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.
Ye Q, Finn PW, Sweeney R, Bikoff EK, Riese RJ
J Immunol. 2003
PubMed ID: 12538710
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules.
Byrne B, Madrigal-Estebas L, McEvoy A, Carton J, Doherty DG, Whelan A, Feighery C, O'Donoghue DP, O'Farrelly C
Hum Immunol. 2002
PubMed ID: 12392850
HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells.
Williams MA, Trout R, Spector SA
J Hematother Stem Cell Res. 2002
PubMed ID: 12427289
Positive selection of self-MHC-reactive T cells by individual peptide-MHC class II complexes.
Barton GM, Beers C, deRoos P, Eastman SR, Gomez ME, Forbush KA, Rudensky AY
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12011451
Negative selection of thymocytes expressing the D10 TCR.
Sant'Angelo DB, Janeway CA
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12011450
Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.
Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L, Jensen PE
J Exp Med. 2002
PubMed ID: 11956296
De novo central nervous system processing of myelin antigen is required for the initiation of experimental autoimmune encephalomyelitis.
Tompkins SM, Padilla J, Dal Canto MC, Ting JP, Van Kaer L, Miller SD
J Immunol. 2002
PubMed ID: 11937578
Dynamics of major histocompatibility complex class II compartments during B cell receptor-mediated cell activation.
Lankar D, Vincent-Schneider H, Briken V, Yokozeki T, Raposo G, Bonnerot C
J Exp Med. 2002
PubMed ID: 11854359
Adapters in lymphocyte signaling.
Leo A, Wienands J, Baier G, Horejsi V, Schraven B
J Clin Invest. 2002
PubMed ID: 11827988
Peptide specificity of thymic selection of CD4+CD25+ T cells.
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J Immunol. 2002
PubMed ID: 11777953
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes.
Kropshofer H, Spindeldreher S, Röhn TA, Platania N, Grygar C, Daniel N, Wölpl A, Langen H, Horejsi V, Vogt AB
Nat Immunol. 2002
PubMed ID: 11743588
In vivo and in vitro modulation of HLA-DM and HLA-DO is induced by B lymphocyte activation.
Roucard C, Thomas C, Pasquier MA, Trowsdale J, Sotto JJ, Neefjes J, van Ham M
J Immunol. 2001
PubMed ID: 11739502
The impact of H2-DM on humoral immune responses.
Alfonso C, Han JO, Williams GS, Karlsson L
J Immunol. 2001
PubMed ID: 11714799
HLA DMA and DMB show no association with rheumatoid arthritis in US Caucasians.
Moxley G, Han J
Eur J Immunogenet. 2001
PubMed ID: 11881821
Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.
Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS
J Clin Invest. 2001
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The major histocompatibility complex of the rat (Rattus norvegicus).
Günther E, Walter L
Immunogenetics. 2001
PubMed ID: 11685465
Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body.
van Lith M, van Ham M, Griekspoor A, Tjin E, Verwoerd D, Calafat J, Janssen H, Reits E, Pastoors L, Neefjes J
J Immunol. 2001
PubMed ID: 11441095
Identification of MHC class II-associated peptides that promote the presentation of toxic shock syndrome toxin-1 to T cells.
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J Immunol. 2001
PubMed ID: 11359802
Identification and characterization of the potential promoter regions of 1031 kinds of human genes.
Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S
Genome Res. 2001
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Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice.
Bikoff EK, Wutz G, Kenty GA, Koonce CH, Robertson EJ
J Immunol. 2001
PubMed ID: 11290790
H2-Mbeta 1 and H2-Mbeta 2 heterodimers equally promote clip removal in I-A(q) molecules from autoimmune-prone DBA/1 mice.
Walter W, Scheuer C, Loos M, Reichert TE, Maeurer MJ
J Biol Chem. 2001
PubMed ID: 11148202
Alpha beta TCRs differ in the degree of their specificity for the positively selecting MHC/peptide ligand.
Kraj P, Pacholczyk R, Ignatowicz L
J Immunol. 2001
PubMed ID: 11160279
Diverse repertoire of the MHC class II-peptide complexes is required for presentation of viral superantigens.
Golovkina T, Agafonova Y, Kazansky D, Chervonsky A
J Immunol. 2001
PubMed ID: 11160278
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in central Sardinia.
Bitti PP, Murgia BS, Ticca A, Ferrai R, Musu L, Piras ML, Puledda E, Campo S, Durando S, Montomoli C, Clayton DG, Mander AP, Bernardinelli L
Genet Epidemiol. 2001
PubMed ID: 11180452
Unusual expression of human lymphocyte antigen class II in normal renal microvascular endothelium.
Muczynski KA, Cotner T, Anderson SK
Kidney Int. 2001
PubMed ID: 11168931
Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA.
Okamoto H, Asamitsu K, Nishimura H, Kamatani N, Okamoto T
Biochem Biophys Res Commun. 2000
PubMed ID: 11118314
On the self-referential nature of naive MHC class II-restricted T cells.
Viret C, He X, Janeway CA
J Immunol. 2000
PubMed ID: 11086052
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance?
Walter W, Lingnau K, Schmitt E, Loos M, Maeurer MJ
Br J Cancer. 2000
PubMed ID: 11027433
Determination of the HLA-DM interaction site on HLA-DR molecules.
Doebele RC, Busch R, Scott HM, Pashine A, Mellins ED
Immunity. 2000
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
The mechanism of phospholipase C-gamma1 regulation.
Kim MJ, Kim E, Ryu SH, Suh PG
Exp Mol Med. 2000
PubMed ID: 11048639
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection.
Felix NJ, Brickey WJ, Griffiths R, Zhang J, Van Kaer L, Coffman T, Ting JP
J Exp Med. 2000
PubMed ID: 10880524
Competition for specific intrathymic ligands limits positive selection in a TCR transgenic model of CD4+ T cell development.
Wong P, Goldrath AW, Rudensky AY
J Immunol. 2000
PubMed ID: 10843678
Functional and phenotypic evidence for presentation of E alpha 52-68 structurally related self-peptide(s) in I-E alpha-deficient mice.
Viret C, Janeway CA
J Immunol. 2000
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Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese.
Zhu X, Zhang Y, Wang Q, Wang F
Chin Med J (Engl). 2000
PubMed ID: 11775239
Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging.
Poon DT, Coren LV, Ott DE
J Virol. 2000
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Functional HLA-DM on the surface of B cells and immature dendritic cells.
Arndt SO, Vogt AB, Markovic-Plese S, Martin R, Moldenhauer G, Wölpl A, Sun Y, Schadendorf D, Hämmerling GJ, Kropshofer H
EMBO J. 2000
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Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection.
Kanazawa S, Okamoto T, Peterlin BM
Immunity. 2000
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The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC class II molecules.
Kropshofer H, Hämmerling GJ, Vogt AB
Immunol Rev. 1999
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Unexpected reactivities of T cells selected by a single MHC-peptide ligand.
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J Immunol. 1999
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In vivo polysaccharide-specific IgG isotype responses to intact Streptococcus pneumoniae are T cell dependent and require CD40- and B7-ligand interactions.
Wu ZQ, Vos Q, Shen Y, Lees A, Wilson SR, Briles DE, Gause WC, Mond JJ, Snapper CM
J Immunol. 1999
PubMed ID: 10395655
A nomenclature solution to mouse MHC confusion.
Rodgers JR, Levitt JM, Cresswell P, Lindahl KF, Mathis D, Monaco JT, Singer DS, Ploegh HL, Bryant PW
J Immunol. 1999
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HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases.
Yen JH, Tsai WC, Tsai JJ, Chen CJ, Lin CH, Ou TT, Wu CC, Liu HW
Kaohsiung J Med Sci. 1999
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Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition.
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Immunity. 1999
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HLA-DM - an endosomal and lysosomal chaperone for the immune system.
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Trends Biochem Sci. 1999
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Peptide dependency of alloreactive CD4+ T cell responses.
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Int Immunol. 1999
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Requirement for diverse, low-abundance peptides in positive selection of T cells.
Barton GM, Rudensky AY
Science. 1999
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High-efficiency full-length cDNA cloning.
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Methods Enzymol. 1999
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Thymic selection by a single MHC/peptide ligand: autoreactive T cells are low-affinity cells.
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Immunity. 1999
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HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cells.
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Arch Dermatol Res. 1998
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The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules.
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J Immunol. 1998
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Crystal structure of mouse H2-M.
Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J
Immunity. 1998
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The structure of HLA-DM, the peptide exchange catalyst that loads antigen onto class II MHC molecules during antigen presentation.
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Immunity. 1998
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The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed.
Wolf PR, Tourne S, Miyazaki T, Benoist C, Mathis D, Ploegh HL
Eur J Immunol. 1998
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An altered invariant chain protein with an antigenic peptide in place of CLIP forms SDS-stable complexes with class II alphabeta dimers and facilitates highly efficient peptide loading.
Barton GM, Rudensky AY
Int Immunol. 1998
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Distinct peptide loading pathways for MHC class II molecules associated with alternative Ii chain isoforms.
Bikoff EK, Kenty G, Van Kaer L
J Immunol. 1998
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Altered antigen presentation in mice lacking H2-O.
Liljedahl M, Winqvist O, Surh CD, Wong P, Ngo K, Teyton L, Peterson PA, Brunmark A, Rudensky AY, Fung-Leung WP, Karlsson L
Immunity. 1998
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Invariant chain-independent function of H-2M in the formation of endogenous peptide-major histocompatibility complex class II complexes in vivo.
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J Exp Med. 1998
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Aberrant intermolecular disulfide bonding in a mutant HLA-DM molecule: implications for assembly, maturation, and function.
Busch R, Doebele RC, von Scheven E, Fahrni J, Mellins ED
J Immunol. 1998
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MHC class II expression in double mutant mice lacking invariant chain and DM functions.
Kenty G, Martin WD, Van Kaer L, Bikoff EK
J Immunol. 1998
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A critical, invariant chain-independent role for H2-M in antigen presentation.
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J Immunol. 1998
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Interaction between HLA-DM and HLA-DR involves regions that undergo conformational changes at lysosomal pH.
Ullrich HJ, Döring K, Grüneberg U, Jähnig F, Trowsdale J, van Ham SM
Proc Natl Acad Sci U S A. 1997
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Negative regulation by HLA-DO of MHC class II-restricted antigen processing.
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Science. 1997
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Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes.
Tourne S, Miyazaki T, Wolf P, Ploegh H, Benoist C, Mathis D
Proc Natl Acad Sci U S A. 1997
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Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides.
Grubin CE, Kovats S, deRoos P, Rudensky AY
Immunity. 1997
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Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice.
Tourne S, Miyazaki T, Oxenius A, Klein L, Fehr T, Kyewski B, Benoist C, Mathis D
Immunity. 1997
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The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway.
Ruff AL, Guarnieri FG, Staveley-O'Carroll K, Siliciano RF, August JT
J Biol Chem. 1997
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Editing of the HLA-DR-peptide repertoire by HLA-DM.
Kropshofer H, Vogt AB, Moldenhauer G, Hammer J, Blum JS, Hämmerling GJ
EMBO J. 1996
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Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DM.
Weber DA, Evavold BD, Jensen PE
Science. 1996
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HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.
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EMBO J. 1996
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Antigen presentation and T cell development in H2-M-deficient mice.
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Science. 1996
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H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection.
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Cell. 1996
PubMed ID: 8598041
Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway.
Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N, Ploegh H, Benoist C, Mathis D
Cell. 1996
PubMed ID: 8598040
Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.
Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J
J Mol Biol. 1996
PubMed ID: 8568858
H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.
Walter W, Loos M, Maeurer MJ
Immunogenetics. 1996
PubMed ID: 8613139
Genomic organization of a mouse MHC class II region including the H2-M and Lmp2 loci.
Péléraux A, Karlsson L, Chambers J, Peterson PA
Immunogenetics. 1996
PubMed ID: 8575819
Association between HLA-DM and HLA-DR in vivo.
Sanderson F, Thomas C, Neefjes J, Trowsdale J
Immunity. 1996
PubMed ID: 8574855
The MHC class II molecule H2-M is targeted to an endosomal compartment by a tyrosine-based targeting motif.
Lindstedt R, Liljedahl M, Péléraux A, Peterson PA, Karlsson L
Immunity. 1995
PubMed ID: 7584146
HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).
Chirmule N, McCloskey TW, Hu R, Kalyanaraman VS, Pahwa S
J Immunol. 1995
PubMed ID: 7541827
Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC.
Rowell JF, Stanhope PE, Siliciano RF
J Immunol. 1995
PubMed ID: 7602119
Characterization of polymorphism within the H2-M MHC class II loci.
Hermel E, Yuan J, Monaco JJ
Immunogenetics. 1995
PubMed ID: 7607704
RT1.DMa and RT1.DMb: the rat homologues of H2-DMa and H2-DMb.
Hermel E, Monaco JJ
Immunogenetics. 1995
PubMed ID: 7590989
Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells.
Karlsson L, Péléraux A, Lindstedt R, Liljedahl M, Peterson PA
Science. 1994
PubMed ID: 7985028
HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41.
Chen YH, Böck G, Vornhagen R, Steindl F, Katinger H, Dierich MP
Mol Immunol. 1994
PubMed ID: 8084338
Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.
Radley E, Alderton RP, Kelly A, Trowsdale J, Beck S
J Biol Chem. 1994
PubMed ID: 8034636
HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4.
Houlgatte R, Scarmato P, el Marhomy S, Martin M, Ostankovitch M, Lafosse S, Vervisch A, Auffray C, Platier-Tonneau D
J Immunol. 1994
PubMed ID: 7512597
Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help.
Chirmule N, Wang XP, Hu R, Oyaizu N, Roifman C, Pahwa R, Kalyanaraman VS, Pahwa S
Cell Immunol. 1994
PubMed ID: 8168144
HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells.
Fling SP, Arp B, Pious D
Nature. 1994
PubMed ID: 8139690
Limited polymorphism in HLA-DM does not involve the peptide binding groove.
Sanderson F, Powis SH, Kelly AP, Trowsdale J
Immunogenetics. 1994
PubMed ID: 8225438
Sequence analysis of two novel HLA-DMA alleles.
Carrington M, Harding A
Immunogenetics. 1994
PubMed ID: 8026867
HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes.
Callahan KM, Rowell JF, Soloski MJ, Machamer CE, Siliciano RF
J Immunol. 1993
PubMed ID: 8376762
Second proteasome-related gene in the human MHC class II region.
Kelly A, Powis SH, Glynne R, Radley E, Beck S, Trowsdale J
Nature. 1991
PubMed ID: 1922385
New class II-like genes in the murine MHC.
Cho SG, Attaya M, Monaco JJ
Nature. 1991
PubMed ID: 1922366
A new human HLA class II-related locus, DM.
Kelly AP, Monaco JJ, Cho SG, Trowsdale J
Nature. 1991
PubMed ID: 1922365
A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex.
Cho S, Attaya M, Brown MG, Monaco JJ
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1711220
Interaction of CD4 with HLA class II antigens and HIV gp120.
Piatier-Tonneau D, Gastinel LN, Amblard F, Wojcik M, Vaigot P, Auffray C
Immunogenetics. 1991
PubMed ID: 1869305
Colinearity of novel genes in the class II regions of the MHC in mouse and human.
Hanson IM, Trowsdale J
Immunogenetics. 1991
PubMed ID: 1855816
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules.
Bowman MR, MacFerrin KD, Schreiber SL, Burakoff SJ
Proc Natl Acad Sci U S A. 1990
PubMed ID: 1978941
HIV-gp120 can block CD4-class II MHC-mediated adhesion.
Rosenstein Y, Burakoff SJ, Herrmann SH
J Immunol. 1990
PubMed ID: 1967269
Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.
Clayton LK, Sieh M, Pious DA, Reinherz EL
Nature. 1989
PubMed ID: 2543930
Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.
Diamond DC, Sleckman BP, Gregory T, Lasky LA, Greenstein JL, Burakoff SJ
J Immunol. 1988
PubMed ID: 2846691
AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications.
Andrieu JM, Even P, Venet A
AIDS Res. 1986
PubMed ID: 3489470

Model Organism Phenotype Links Top Help

This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.

Organism	Phenotype	Resources
Mouse	MGI:95921	IKMC

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	3108	14998	294274
EnsEMBL Gene(s)	ENSG00000204257 ENSG00000239463 ENSG00000241394 ENSG00000242361 ENSG00000242685 ENSG00000243189 ENSG00000243215 ENSG00000243719	ENSMUSG00000037649	ENSRNOG00000000460
Unigene	Hs.728759	Mm.16373	Rn.35809
Homologene	HLA-DMA	H2-DMa	RT1-DMa
OMIM	142855	N/A	N/A
GeneCards	HLA-DMA	N/A	N/A
Beta Cell Genomics	DT.100817259 DT.417533	DT.533879 DT.91299890	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
MGI	N/A	MGI:95921	N/A
WikiGenes	3108	14998	294274

External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network Top Help

Relevant resources:

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