H2AFX

Summary Top Help

Gene Description:

H2A histone family, member X

Synonyms:

gammaH2ax, Hist5-2ax, RGD1566119, H2AX, H2AFX, H2afx, H2A/X, AW228881, H2A.X, H2ax

Orthologs:

Human H2AFX (protein-coding), Mouse H2afx (protein-coding), Rat H2afx (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Mouse: 1

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Idd2	Mouse	chr9:32308040..98698811	66.39	764	6 no lod score

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr11:118964564..118966177 (1.61 kb) View in Genome Browser

(Mouse) NCBIM37 - chr9:44142798..44144160 (1.36 kb) View in Genome Browser

(Rat) RGSC3.4 - chr8:47312609..47313938 (1.33 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for H2AFX:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for H2AFX:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 1

Biocarta: None available

Reactome: 14

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 20

Publications from PubMed Top Help

Publications: 361

Msx1 and Msx2 promote meiosis initiation.
Le Bouffant R, Souquet B, Duval N, Duquenne C, Hervé R, Frydman N, Robert B, Habert R, Livera G
Development. 2011
PubMed ID: 22071108
H2AFX polymorphisms are associated with decreased risk of diffuse large B cell lymphoma in Koreans.
Jin XM, Kim HN, Shin MH, Lee IK, Lee JS, Lee JH, Kim HJ, Choi JS, Juhng SW, Choi C
DNA Cell Biol. 2011
PubMed ID: 21631283
Gammaherpesvirus gene expression and DNA synthesis are facilitated by viral protein kinase and histone variant H2AX.
Mounce BC, Tsan FC, Droit L, Kohler S, Reitsma JM, Cirillo LA, Tarakanova VL
Virology. 2011
PubMed ID: 21943826
immunohistochemical expression of survivin and γ-H2AX in vulvar intraepithelial neoplasia and low-stage squamous cell carcinoma.
Brustmann H, Hinterholzer S, Brunner A
Int J Gynecol Pathol. 2011
PubMed ID: 21979596
Possible association between genetic variants in the H2AFX promoter region and risk of adult glioma in a Chinese Han population.
Fan W, Zhou K, Zhao Y, Wu W, Chen H, Jin L, Chen G, Shi J, Wei Q, Zhang T, Du G, Mao Y, Lu D, Zhou L
J Neurooncol. 2011
PubMed ID: 21512825
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Zhang W, Peng G, Lin SY, Zhang P
J Biol Chem. 2011
PubMed ID: 21878640
Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.
Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A
Mol Cell Biol. 2011
PubMed ID: 21791604
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.
Wu CY, Kang HY, Yang WL, Wu J, Jeong YS, Wang J, Chan CH, Lee SW, Zhang X, Lamothe B, Campos AD, Darnay BG, Lin HK
J Biol Chem. 2011
PubMed ID: 21690091
Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.
Otterbein LE, Hedblom A, Harris C, Csizmadia E, Gallo D, Wegiel B
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21849621
MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner.
Strauss C, Halevy T, Macarov M, Argaman L, Goldberg M
DNA Repair (Amst). 2011
PubMed ID: 21622030
Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis.
Le Masson F, Razak Z, Kaigo M, Audouard C, Charry C, Cooke H, Westwood JT, Christians ES
Mol Cell Biol. 2011
PubMed ID: 21690297
DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.
Krentz AD, Murphy MW, Sarver AL, Griswold MD, Bardwell VJ, Zarkower D
Dev Biol. 2011
PubMed ID: 21621532
Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX.
Walters DK, Wu X, Tschumper RC, Arendt BK, Huddleston PM, Henderson KJ, Dispenzieri A, Jelinek DF
Leukemia. 2011
PubMed ID: 21566653
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.
Fernández-Miranda G, Trakala M, Martín J, Escobar B, González A, Ghyselinck NB, Ortega S, Cañamero M, Pérez de Castro I, Malumbres M
Development. 2011
PubMed ID: 21613325
Kinetics of gamma-H2AX induction and removal in bone marrow and testicular cells of mice after X-ray irradiation.
Paris L, Cordelli E, Eleuteri P, Grollino MG, Pasquali E, Ranaldi R, Meschini R, Pacchierotti F
Mutagenesis. 2011
PubMed ID: 21498842
Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY body to the nucleolus during prophase of male meiosis I.
Tsutsumi M, Kogo H, Kowa-Sugiyama H, Inagaki H, Ohye T, Kurahashi H
Biol Reprod. 2011
PubMed ID: 21451147
Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis.
Holloway JK, Mohan S, Balmus G, Sun X, Modzelewski A, Borst PL, Freire R, Weiss RS, Cohen PE
PLoS Genet. 2011
PubMed ID: 21655083
H2AX gene does not have a modifier effect on ataxia-telangiectasia phenotype.
Mesci L, Ozdag H, Yel L, Ozgur TT, Tan C, Sanal O
Int J Immunogenet. 2011
PubMed ID: 21199394
Phosphorylation of histone H2A.X as an early marker of neuronal endangerment following seizures in the adult rat brain.
Crowe SL, Tsukerman S, Gale K, Jorgensen TJ, Kondratyev AD
J Neurosci. 2011
PubMed ID: 21613478
Functional relevance of the histone gammaH2Ax in the response to DNA damaging agents.
Revet I, Feeney L, Bruguera S, Wilson W, Dong TK, Oh DH, Dankort D, Cleaver JE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21555580
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG
Dev Biol. 2011
PubMed ID: 21385577
Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.
Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Tóth A
Nat Cell Biol. 2011
PubMed ID: 21478856
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Ginjala V, Nacerddine K, Kulkarni A, Oza J, Hill SJ, Yao M, Citterio E, van Lohuizen M, Ganesan S
Mol Cell Biol. 2011
PubMed ID: 21383063
MDC1 collaborates with TopBP1 in DNA replication checkpoint control.
Wang J, Gong Z, Chen J
J Cell Biol. 2011
PubMed ID: 21482717
Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells.
Fernando RN, Eleuteri B, Abdelhady S, Nussenzweig A, Andäng M, Ernfors P
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21436033
Replication stress induces 53BP1-containing OPT domains in G1 cells.
Harrigan JA, Belotserkovskaya R, Coates J, Dimitrova DS, Polo SE, Bradshaw CR, Fraser P, Jackson SP
J Cell Biol. 2011
PubMed ID: 21444690
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M
J Cell Biol. 2011
PubMed ID: 21383078
Cell proliferation in the absence of E2F1-3.
Wenzel PL, Chong JL, Sáenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G
Dev Biol. 2011
PubMed ID: 21185283
Nuclear damage in peripheral lymphocytes of obese and overweight Italian children as evaluated by the gamma-H2AX focus assay and micronucleus test.
Scarpato R, Verola C, Fabiani B, Bianchi V, Saggese G, Federico G
FASEB J. 2011
PubMed ID: 21068397
Ectopic expression of H2AX protein promotes TrkA-induced cell death via modulation of TrkA tyrosine-490 phosphorylation and JNK activity upon DNA damage.
Jung EJ, Kim DR
Biochem Biophys Res Commun. 2011
PubMed ID: 21184737
Phosphorylation of H2AX at Ser139 and a new phosphorylation site Ser16 by RSK2 decreases H2AX ubiquitination and inhibits cell transformation.
Zhu F, Zykova TA, Peng C, Zhang J, Cho YY, Zheng D, Yao K, Ma WY, Lau AT, Bode AM, Dong Z
Cancer Res. 2011
PubMed ID: 21224359
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.
Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP
Nature. 2011
PubMed ID: 21160476
ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.
Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW
Nature. 2011
PubMed ID: 21160472
Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.
Yin B, Yang-Iott KS, Chao LH, Bassing CH
Blood. 2011
PubMed ID: 20947684
[Phosphorylation of histone H2AX in human lymphocytes as a possible marker of effective cellular response to ionizing radiation].
Firsanov DV, Kropotov AV, Tomilin NV
Tsitologiia. 2011
PubMed ID: 21938931
Onset of quiescence following p53 mediated down-regulation of H2AX in normal cells.
Atsumi Y, Fujimori H, Fukuda H, Inase A, Shinohe K, Yoshioka Y, Shikanai M, Ichijima Y, Unno J, Mizutani S, Tsuchiya N, Hippo Y, Nakagama H, Masutani M, Teraoka H, Yoshioka K
PLoS One. 2011
PubMed ID: 21858116
Replication stress induces micronuclei comprising of aggregated DNA double-strand breaks.
Xu B, Sun Z, Liu Z, Guo H, Liu Q, Jiang H, Zou Y, Gong Y, Tischfield JA, Shao C
PLoS One. 2011
PubMed ID: 21525980
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Lack of a correlation between γH2AX foci kinetics in lymphocytes and the severity of acute normal tissue reactions during IMRT treatment for head and neck cancer.
Werbrouck J, Duprez F, De Neve W, Thierens H
Int J Radiat Biol. 2011
PubMed ID: 21142613
Expression of phosphorylated histone H2AX (γ-H2AX) in normal and neoplastic squamous epithelia of the uterine cervix: an immunohistochemical study with epidermal growth factor receptor.
Brustmann H, Hinterholzer S, Brunner A
Int J Gynecol Pathol. 2011
PubMed ID: 21131828
MST1 promotes apoptosis through phosphorylation of histone H2AX.
Wen W, Zhu F, Zhang J, Keum YS, Zykova T, Yao K, Peng C, Zheng D, Cho YY, Ma WY, Bode AM, Dong Z
J Biol Chem. 2010
PubMed ID: 20921231
Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice.
Nashun B, Yukawa M, Liu H, Akiyama T, Aoki F
Development. 2010
PubMed ID: 20943707
New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice.
Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G
Dev Biol. 2010
PubMed ID: 20707993
Histone deacetylase inhibitors valproic acid and depsipeptide sensitize retinoblastoma cells to radiotherapy by increasing H2AX phosphorylation and p53 acetylation-phosphorylation.
Kawano T, Akiyama M, Agawa-Ohta M, Mikami-Terao Y, Iwase S, Yanagisawa T, Ida H, Agata N, Yamada H
Int J Oncol. 2010
PubMed ID: 20811699
Opposite expression of securin and γ-H2AX regulates baicalein-induced cancer cell death.
Jiang RH, Su WC, Liu HF, Huang HS, Chao JI
J Cell Biochem. 2010
PubMed ID: 20506293
Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.
Redon CE, Nakamura AJ, Zhang YW, Ji JJ, Bonner WM, Kinders RJ, Parchment RE, Doroshow JH, Pommier Y
Clin Cancer Res. 2010
PubMed ID: 20823146
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4.
Polo SE, Kaidi A, Baskcomb L, Galanty Y, Jackson SP
EMBO J. 2010
PubMed ID: 20693977
Conserved gammaherpesvirus kinase and histone variant H2AX facilitate gammaherpesvirus latency in vivo.
Tarakanova VL, Stanitsa E, Leonardo SM, Bigley TM, Gauld SB
Virology. 2010
PubMed ID: 20557919
FGF9 suppresses meiosis and promotes male germ cell fate in mice.
Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P
Dev Cell. 2010
PubMed ID: 20833365
H2AX post-translational modifications in the ionizing radiation response and homologous recombination.
Xie A, Odate S, Chandramouly G, Scully R
Cell Cycle. 2010
PubMed ID: 20703100
Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.
Heacock ML, Stefanick DF, Horton JK, Wilson SH
DNA Repair (Amst). 2010
PubMed ID: 20573551
Quantification of gamma-H2AX foci in human lymphocytes: a method for biological dosimetry after ionizing radiation exposure.
Roch-Lefèvre S, Mandina T, Voisin P, Gaëtan G, Mesa JE, Valente M, Bonnesoeur P, García O, Voisin P, Roy L
Radiat Res. 2010
PubMed ID: 20681785
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
Pozuelo-Rubio M
FEBS J. 2010
PubMed ID: 20618440
Differences in the kinetics of gamma-H2AX fluorescence decay after exposure to low and high LET radiation.
Schmid TE, Dollinger G, Beisker W, Hable V, Greubel C, Auer S, Mittag A, Tarnok A, Friedl AA, Molls M, Röper B
Int J Radiat Biol. 2010
PubMed ID: 20569192
Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.
Wang WL, Li Q, Xu J, Cvekl A
Mol Biol Cell. 2010
PubMed ID: 20484573
Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway.
Jiang X, Xu Y, Price BD
FEBS Lett. 2010
PubMed ID: 20488183
Nucleosome occupancy landscape and dynamics at mouse recombination hotspots.
Getun IV, Wu ZK, Khalil AM, Bois PR
EMBO Rep. 2010
PubMed ID: 20508641
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.
Sharma GG, So S, Gupta A, Kumar R, Cayrou C, Avvakumov N, Bhadra U, Pandita RK, Porteus MH, Chen DJ, Cote J, Pandita TK
Mol Cell Biol. 2010
PubMed ID: 20479123
Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice.
Kumar R, Bourbon HM, de Massy B
Genes Dev. 2010
PubMed ID: 20551173
Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding.
Li A, Yu Y, Lee SC, Ishibashi T, Lees-Miller SP, Ausió J
J Biol Chem. 2010
PubMed ID: 20356835
DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death.
Ho CY, Li HY
J Cell Biochem. 2010
PubMed ID: 20512932
Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ
Cancer Res. 2010
PubMed ID: 20460517
H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype.
Vasireddy RS, Sprung CN, Cempaka NL, Chao M, McKay MJ
Br J Cancer. 2010
PubMed ID: 20461094
AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX.
Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, Lenormand P, Rousselle JC, Namane A, England P, Lorenzo HK, Susin SA
EMBO J. 2010
PubMed ID: 20360685
Radiation-induced survivin nuclear accumulation is linked to DNA damage repair.
Capalbo G, Dittmann K, Weiss C, Reichert S, Hausmann E, Rödel C, Rödel F
Int J Radiat Oncol Biol Phys. 2010
PubMed ID: 20394854
DNA damage detected with gammaH2AX in endometrioid adenocarcinoma cell lines.
Ikeda M, Kurose A, Takatori E, Sugiyama T, Traganos F, Darzynkiewicz Z, Sawai T
Int J Oncol. 2010
PubMed ID: 20372780
The exon junction complex component Magoh controls brain size by regulating neural stem cell division.
Silver DL, Watkins-Chow DE, Schreck KC, Pierfelice TJ, Larson DM, Burnetti AJ, Liaw HJ, Myung K, Walsh CA, Gaiano N, Pavan WJ
Nat Neurosci. 2010
PubMed ID: 20364144
Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S
Mol Cell Biol. 2010
PubMed ID: 20231360
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA
J Biol Chem. 2010
PubMed ID: 20118229
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.
Iacovoni JS, Caron P, Lassadi I, Nicolas E, Massip L, Trouche D, Legube G
EMBO J. 2010
PubMed ID: 20360682
A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair.
Lee HS, Park JH, Kim SJ, Kwon SJ, Kwon J
EMBO J. 2010
PubMed ID: 20224553
Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development.
Naillat F, Prunskaite-Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, Vainio SJ
Hum Mol Genet. 2010
PubMed ID: 20106871
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH
Oncogene. 2010
PubMed ID: 20101220
A minority of foci or pan-nuclear apoptotic staining of gammaH2AX in the S phase after UV damage contain DNA double-strand breaks.
de Feraudy S, Revet I, Bezrookove V, Feeney L, Cleaver JE
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20351298
A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice.
Endoh-Yamagami S, Karkar KM, May SR, Cobos I, Thwin MT, Long JE, Ashique AM, Zarbalis K, Rubenstein JL, Peterson AS
Dev Biol. 2010
PubMed ID: 20096683
HSP72 depletion suppresses gammaH2AX activation by genotoxic stresses via p53/p21 signaling.
Gabai VL, Sherman MY, Yaglom JA
Oncogene. 2010
PubMed ID: 20062073
The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage.
Lee JH, Kang Y, Khare V, Jin ZY, Kang MY, Yoon Y, Hyun JW, Chung MH, Cho SI, Jun JY, Chang IY, You HJ
Oncogene. 2010
PubMed ID: 20023697
Proteomic dissection of cell type-specific H2AX-interacting protein complex associated with hepatocellular carcinoma.
Yang X, Zou P, Yao J, Yun D, Bao H, Du R, Long J, Chen X
J Proteome Res. 2010
PubMed ID: 20000738
Enhanced H2AX phosphorylation, DNA replication fork arrest, and cell death in the absence of Chk1.
Gagou ME, Zuazua-Villar P, Meuth M
Mol Biol Cell. 2010
PubMed ID: 20053681
GammaH2AX as a molecular marker of aging and disease.
Mah LJ, El-Osta A, Karagiannis TC
Epigenetics. 2010
PubMed ID: 20150765
DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.
Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T
Cancer Prev Res (Phila Pa). 2010
PubMed ID: 20028875
DNA damage signaling is activated during cancer progression in human colorectal carcinoma.
Oka K, Tanaka T, Enoki T, Yoshimura K, Ohshima M, Kubo M, Murakami T, Gondou T, Minami Y, Takemoto Y, Harada E, Tsushimi T, Li TS, Traganos F, Darzynkiewicz Z, Hamano K
Cancer Biol Ther. 2010
PubMed ID: 20023412
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.
Nakamura AJ, Rao VA, Pommier Y, Bonner WM
Cell Cycle. 2010
PubMed ID: 20046100
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.
Yuan J, Chen J
J Biol Chem. 2010
PubMed ID: 19910469
The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates.
Redon CE, Nakamura AJ, Gouliaeva K, Rahman A, Blakely WF, Bonner WM
PLoS One. 2010
PubMed ID: 21124906
Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity.
Vandersickel V, Depuydt J, Van Bockstaele B, Perletti G, Philippe J, Thierens H, Vral A
J Radiat Res (Tokyo). 2010
PubMed ID: 21116096
BRCA1 Forms a Functional Complex with γ-H2AX as a Late Response to Genotoxic Stress.
Krum SA, la Rosa Dalugdugan E, Miranda-Carboni GA, Lane TF
J Nucleic Acids. 2010
PubMed ID: 20936109
UPF2 is a critical regulator of liver development, function and regeneration.
Thoren LA, Nørgaard GA, Weischenfeldt J, Waage J, Jakobsen JS, Damgaard I, Bergström FC, Blom AM, Borup R, Bisgaard HC, Porse BT
PLoS One. 2010
PubMed ID: 20657840
Experimental varicocele induces p53-dependent germ cell apoptosis through activation of γ-H2AX.
Chang IY, Kim JH, Park KH, Yoon SP
Urol Int. 2010
PubMed ID: 20530960
ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.
Takahashi A, Mori E, Su X, Nakagawa Y, Okamoto N, Uemura H, Kondo N, Noda T, Toki A, Ejima Y, Chen DJ, Ohnishi K, Ohnishi T
J Radiat Res (Tokyo). 2010
PubMed ID: 20448412
The foci of DNA double strand break-recognition proteins localize with gammaH2AX after heat treatment.
Takahashi A, Mori E, Ohnishi T
J Radiat Res (Tokyo). 2010
PubMed ID: 20173316
Residual gammaH2AX foci as an indication of lethal DNA lesions.
Banáth JP, Klokov D, MacPhail SH, Banuelos CA, Olive PL
BMC Cancer. 2010
PubMed ID: 20051134
Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix.
Olive PL, Banuelos CA, Durand RE, Kim JY, Aquino-Parsons C
Radiother Oncol. 2010
PubMed ID: 19903578
Dicer is required for Sertoli cell function and survival.
Kim GJ, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F
Int J Dev Biol. 2010
PubMed ID: 19876815
gamma-radiation-induced gammaH2AX formation occurs preferentially in actively transcribing euchromatic loci.
Vasireddy RS, Karagiannis TC, El-Osta A
Cell Mol Life Sci. 2010
PubMed ID: 19859659
Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX.
Yamagata K, Kitabayashi I
Biochem Biophys Res Commun. 2009
PubMed ID: 19895790
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC
Blood. 2009
PubMed ID: 19850743
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S
Dev Cell. 2009
PubMed ID: 20059948
G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells.
Zhou WJ, Deng R, Zhang XY, Feng GK, Gu LQ, Zhu XF
Mol Cancer Ther. 2009
PubMed ID: 19996277
Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.
Ballot C, Kluza J, Martoriati A, Nyman U, Formstecher P, Joseph B, Bailly C, Marchetti P
Mol Cancer Ther. 2009
PubMed ID: 19952118
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation.
Ray A, Mir SN, Wani G, Zhao Q, Battu A, Zhu Q, Wang QE, Wani AA
Mol Cell Biol. 2009
PubMed ID: 19805520
H2AX: functional roles and potential applications.
Dickey JS, Redon CE, Nakamura AJ, Baird BJ, Sedelnikova OA, Bonner WM
Chromosoma. 2009
PubMed ID: 19707781
Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination.
Yin B, Savic V, Juntilla MM, Bredemeyer AL, Yang-Iott KS, Helmink BA, Koretzky GA, Sleckman BP, Bassing CH
J Exp Med. 2009
PubMed ID: 19887394
Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations.
Schoeftner S, Blanco R, de Silanes IL, Muñoz P, Gómez-López G, Flores JM, Blasco MA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19887628
Dmap1 plays an essential role in the maintenance of genome integrity through the DNA repair process.
Negishi M, Chiba T, Saraya A, Miyagi S, Iwama A
Genes Cells. 2009
PubMed ID: 19845771
Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes.
Yoshimura T, Toyoda S, Kuramochi-Miyagawa S, Miyazaki T, Miyazaki S, Tashiro F, Yamato E, Nakano T, Miyazaki J
Dev Biol. 2009
PubMed ID: 19735653
Cell cycle-dependent role of MRN at dysfunctional telomeres: ATM signaling-dependent induction of nonhomologous end joining (NHEJ) in G1 and resection-mediated inhibition of NHEJ in G2.
Dimitrova N, de Lange T
Mol Cell Biol. 2009
PubMed ID: 19667071
Intercellular communication of cellular stress monitored by gamma-H2AX induction.
Dickey JS, Baird BJ, Redon CE, Sokolov MV, Sedelnikova OA, Bonner WM
Carcinogenesis. 2009
PubMed ID: 19651821
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency.
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T
Mol Cell. 2009
PubMed ID: 19716796
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Gottschalk AJ, Timinszky G, Kong SE, Jin J, Cai Y, Swanson SK, Washburn MP, Florens L, Ladurner AG, Conaway JW, Conaway RC
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666485
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
Pugh TJ, Keyes M, Barclay L, Delaney A, Krzywinski M, Thomas D, Novik K, Yang C, Agranovich A, McKenzie M, Morris WJ, Olive PL, Marra MA, Moore RA
Clin Cancer Res. 2009
PubMed ID: 19638463
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1.
Lee Y, Katyal S, Li Y, El-Khamisy SF, Russell HR, Caldecott KW, McKinnon PJ
Nat Neurosci. 2009
PubMed ID: 19633665
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O
Nat Genet. 2009
PubMed ID: 19620979
The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein.
Reynard LN, Cocquet J, Burgoyne PS
Biol Reprod. 2009
PubMed ID: 19176879
BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes.
Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Höög C
J Cell Sci. 2009
PubMed ID: 19531582
Persistence of histone H2AX phosphorylation after meiotic chromosome synapsis and abnormal centromere cohesion in poly (ADP-ribose) polymerase (Parp-1) null oocytes.
Yang F, Baumann C, De La Fuente R
Dev Biol. 2009
PubMed ID: 19463809
Histone H2A.X Tyr142 phosphorylation: a novel sWItCH for apoptosis?
Stucki M
DNA Repair (Amst). 2009
PubMed ID: 19446503
TAp63 prevents premature aging by promoting adult stem cell maintenance.
Su X, Paris M, Gi YJ, Tsai KY, Cho MS, Lin YL, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, Flores ER
Cell Stem Cell. 2009
PubMed ID: 19570515
gammaH2AX and cleaved PARP-1 as apoptotic markers in irradiated breast cancer BT474 cellular spheroids.
Qvarnström OF, Simonsson M, Eriksson V, Turesson I, Carlsson J
Int J Oncol. 2009
PubMed ID: 19513550
Haploinsufficiency and acquired loss of Bcl11b and H2AX induces blast crisis of chronic myelogenous leukemia in a transgenic mouse model.
Nagamachi A, Yamasaki N, Miyazaki K, Oda H, Miyazaki M, Honda Z, Kominami R, Inaba T, Honda H
Cancer Sci. 2009
PubMed ID: 19432895
The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.
Barroso E, Pita G, Arias JI, Menendez P, Zamora P, Blanco M, Benitez J, Ribas G
Breast Cancer Res Treat. 2009
PubMed ID: 19536649
Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent.
Krishnan N, Jeong DG, Jung SK, Ryu SE, Xiao A, Allis CD, Kim SJ, Tonks NK
J Biol Chem. 2009
PubMed ID: 19351884
Bringing H2AX into the angiogenesis family.
Rankin EB, Giaccia AJ, Hammond EM
Cancer Cell. 2009
PubMed ID: 19477424
Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication.
Nichols GJ, Schaack J, Ornelles DA
J Virol. 2009
PubMed ID: 19321613
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.
Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, Yang-Iott KS, Sleckman BP, Bassing CH
Mol Cell. 2009
PubMed ID: 19450528
gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.
Bañuelos CA, Banáth JP, Kim JY, Aquino-Parsons C, Olive PL
Clin Cancer Res. 2009
PubMed ID: 19401347
Histone H2AX is integral to hypoxia-driven neovascularization.
Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T
Nat Med. 2009
PubMed ID: 19377486
miR-24-mediated downregulation of H2AX suppresses DNA repair in terminally differentiated blood cells.
Lal A, Pan Y, Navarro F, Dykxhoorn DM, Moreau L, Meire E, Bentwich Z, Lieberman J, Chowdhury D
Nat Struct Mol Biol. 2009
PubMed ID: 19377482
H2AX is required for cell cycle arrest via the p53/p21 pathway.
Fragkos M, Jurvansuu J, Beard P
Mol Cell Biol. 2009
PubMed ID: 19273588
Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells.
Banáth JP, Bañuelos CA, Klokov D, MacPhail SM, Lansdorp PM, Olive PL
Exp Cell Res. 2009
PubMed ID: 19154734
Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.
Ocio EM, Maiso P, Chen X, Garayoa M, Alvarez-Fernández S, San-Segundo L, Vilanova D, López-Corral L, Montero JC, Hernández-Iglesias T, de Alava E, Galmarini C, Avilés P, Cuevas C, San-Miguel JF, Pandiella A
Blood. 2009
PubMed ID: 19020308
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions.
Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG
Nature. 2009
PubMed ID: 19234442
Forskolin decreases phosphorylation of histone H2AX in human cells induced by ionizing radiation.
Solovjeva LV, Pleskach NM, Firsanov DV, Svetlova MP, Serikov VB, Tomilin NV
Radiat Res. 2009
PubMed ID: 19397442
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
Oda H, Okamoto I, Murphy N, Chu J, Price SM, Shen MM, Torres-Padilla ME, Heard E, Reinberg D
Mol Cell Biol. 2009
PubMed ID: 19223465
RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage.
Ni L, Saeki M, Xu L, Nakahara H, Saijo M, Tanaka K, Kamisaki Y
J Cell Biochem. 2009
PubMed ID: 19180575
Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.
Kobayashi J, Tauchi H, Chen B, Burma S, Bruma S, Tashiro S, Matsuura S, Tanimoto K, Chen DJ, Komatsu K
Biochem Biophys Res Commun. 2009
PubMed ID: 19338747
Testis cord differentiation after the sex determination stage is independent of Sox9 but fails in the combined absence of Sox9 and Sox8.
Barrionuevo F, Georg I, Scherthan H, Lécureuil C, Guillou F, Wegner M, Scherer G
Dev Biol. 2009
PubMed ID: 19124014
Ectopic expression of histone H2AX mutants reveals a role for its post-translational modifications.
Rios-Doria J, Velkova A, Dapic V, Galán-Caridad JM, Dapic V, Carvalho MA, Melendez J, Monteiro AN
Cancer Biol Ther. 2009
PubMed ID: 19305155
H2AX phosphorylation and kinetics of radiation-induced DNA double strand break repair in human primary thyrocytes.
Galleani J, Miranda C, Pierotti MA, Greco A
Thyroid. 2009
PubMed ID: 19265496
Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities.
Yoshikawa T, Kashino G, Ono K, Watanabe M
J Radiat Res (Tokyo). 2009
PubMed ID: 19202324
Histone H2AX phosphorylation in response to changes in chromatin structure induced by altered osmolarity.
Baure J, Izadi A, Suarez V, Giedzinski E, Cleaver JE, Fike JR, Limoli CL
Mutagenesis. 2009
PubMed ID: 19064695
Kinetics of H2AX phosphorylation after exposure to cisplatin.
Olive PL, Banáth JP
Cytometry B Clin Cytom. 2009
PubMed ID: 18727058
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C
Cell. 2009
PubMed ID: 19203579
The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage.
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, Durandy A, Byrd PJ, Stankovic T, Taylor AM, Durocher D
Cell. 2009
PubMed ID: 19203578
Endogenous DNA breaks: gammaH2AX and the role of telomeres.
Olive PL
Aging (Albany NY). 2009
PubMed ID: 20157507
Sex-specific roles of beta-catenin in mouse gonadal development.
Liu CF, Bingham N, Parker K, Yao HH
Hum Mol Genet. 2009
PubMed ID: 18981061
A mouse speciation gene encodes a meiotic histone H3 methyltransferase.
Mihola O, Trachtulec Z, Vlcek C, Schimenti JC, Forejt J
Science. 2009
PubMed ID: 19074312
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.
Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ
Genes Dev. 2009
PubMed ID: 19171781
gamma-H2AX as protein biomarker for radiation exposure.
Rothkamm K, Horn S
Ann Ist Super Sanita. 2009
PubMed ID: 19861731
Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage.
Ziegler-Birling C, Helmrich A, Tora L, Torres-Padilla ME
Int J Dev Biol. 2009
PubMed ID: 19598117
RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX.
Pinato S, Scandiuzzi C, Arnaudo N, Citterio E, Gaudino G, Penengo L
BMC Mol Biol. 2009
PubMed ID: 19500350
ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes.
Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldés M
Reprod Biomed Online. 2009
PubMed ID: 19146767
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, Ishibe-Murakami S, Wang B, Tempst P, Hofmann K, Patel DJ, Elledge SJ, Allis CD
Nature. 2009
PubMed ID: 19092802
Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia.
Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J
Dev Biol. 2009
PubMed ID: 19014927
Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways.
Solier S, Sordet O, Kohn KW, Pommier Y
Mol Cell Biol. 2009
PubMed ID: 18955500
Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.
Wang B, Malik R, Nigg EA, Körner R
Anal Chem. 2008
PubMed ID: 19007248
Germ cell-intrinsic and -extrinsic factors govern meiotic initiation in mouse embryos.
Lin Y, Gill ME, Koubova J, Page DC
Science. 2008
PubMed ID: 19074348
GammaH2AX and cancer.
Bonner WM, Redon CE, Dickey JS, Nakamura AJ, Sedelnikova OA, Solier S, Pommier Y
Nat Rev Cancer. 2008
PubMed ID: 19005492
A phenotypic spectrum of sexual development in Dax1 (Nr0b1)-deficient mice: consequence of the C57BL/6J strain on sex determination.
Park SY, Lee EJ, Emge D, Jahn CL, Jameson JL
Biol Reprod. 2008
PubMed ID: 18633137
Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.
Koike M, Sugasawa J, Yasuda M, Koike A
Biochem Biophys Res Commun. 2008
PubMed ID: 18755145
Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Manuylov NL, Smagulova FO, Leach L, Tevosian SG
Development. 2008
PubMed ID: 18927154
Expression of gamma-H2AX in melanocytic lesions.
Wasco MJ, Pu RT, Yu L, Su L, Ma L
Hum Pathol. 2008
PubMed ID: 18656236
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage.
Li H, Balajee AS, Su T, Cen B, Hei TK, Weinstein IB
J Cell Biol. 2008
PubMed ID: 18852295
ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.
Ewald B, Sampath D, Plunkett W
Cancer Res. 2008
PubMed ID: 18829552
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.
Meierhofer D, Wang X, Huang L, Kaiser P
J Proteome Res. 2008
PubMed ID: 18781797
Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal.
Maatouk DM, DiNapoli L, Alvers A, Parker KL, Taketo MM, Capel B
Hum Mol Genet. 2008
PubMed ID: 18617533
Histone H2AX is a critical factor for cellular protection against DNA alkylating agents.
Meador JA, Zhao M, Su Y, Narayan G, Geard CR, Balajee AS
Oncogene. 2008
PubMed ID: 18542054
Loss of histone H2AX increases sensitivity of immortalized mouse fibroblasts to the topoisomerase II inhibitor etoposide.
Donà F, Prosperi E, Savio M, Coppa T, Scovassi AI, Mondello C
Int J Oncol. 2008
PubMed ID: 18695893
Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway.
Lu C, Shi Y, Wang Z, Song Z, Zhu M, Cai Q, Chen T
FEBS Lett. 2008
PubMed ID: 18619440
Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis.
Soper SF, van der Heijden GW, Hardiman TC, Goodheart M, Martin SL, de Boer P, Bortvin A
Dev Cell. 2008
PubMed ID: 18694567
Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation.
Mahadevaiah SK, Bourc'his D, de Rooij DG, Bestor TH, Turner JM, Burgoyne PS
J Cell Biol. 2008
PubMed ID: 18663141
A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.
Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J
Mol Cell. 2008
PubMed ID: 18614045
Accumulation of DSBs in gamma-H2AX domains fuel chromosomal aberrations.
Scherthan H, Hieber L, Braselmann H, Meineke V, Zitzelsberger H
Biochem Biophys Res Commun. 2008
PubMed ID: 18457664
Complementary functions of ATM and H2AX in development and suppression of genomic instability.
Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18599436
Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ.
Koike M, Mashino M, Sugasawa J, Koike A
J Radiat Res (Tokyo). 2008
PubMed ID: 18413980
Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged
Lu J, Wei Q, Bondy ML, Brewster AM, Bevers TB, Yu TK, Buchholz TA, Meric-Bernstam F, Hunt KK, Singletary SE, Wang LE
Breast Cancer Res Treat. 2008
PubMed ID: 17851762

The R215W mutation in NBS1 impairs gamma-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients.
di Masi A, Viganotti M, Polticelli F, Ascenzi P, Tanzarella C, Antoccia A
Biochem Biophys Res Commun. 2008
PubMed ID: 18328813

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.
Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W
Mol Cell. 2008
PubMed ID: 18406329

Functional interaction between FOXO3a and ATM regulates DNA damage response.
Tsai WB, Chung YM, Takahashi Y, Xu Z, Hu MC
Nat Cell Biol. 2008
PubMed ID: 18344987

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.
Jha S, Shibata E, Dutta A
Mol Cell Biol. 2008
PubMed ID: 18285460

Absence of the H2AX mutations in idiopathic infertile men with spermatogenic impairment.
Zhang W, Yang Y, Su D, Ma Y, Zhang S
Syst Biol Reprod Med. 2008
PubMed ID: 18536151

Meiotic failure in male mice lacking an X-linked factor.
Yang F, Gell K, van der Heijden GW, Eckardt S, Leu NA, Page DC, Benavente R, Her C, Höög C, McLaughlin KJ, Wang PJ
Genes Dev. 2008
PubMed ID: 18316482

Ribosomal proteins are targets for the NEDD8 pathway.
Xirodimas DP, Sundqvist A, Nakamura A, Shen L, Botting C, Hay RT
EMBO Rep. 2008
PubMed ID: 18274552

Residual gammaH2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy.
Olive PL, Banáth JP, Keyes M
Radiother Oncol. 2008
PubMed ID: 17904670

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.
Yang F, Eckardt S, Leu NA, McLaughlin KJ, Wang PJ
J Cell Biol. 2008
PubMed ID: 18283110

Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations.
Bassing CH, Ranganath S, Murphy M, Savic V, Gleason M, Alt FW
Blood. 2008
PubMed ID: 17855626

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation.
Andäng M, Hjerling-Leffler J, Moliner A, Lundgren TK, Castelo-Branco G, Nanou E, Pozas E, Bryja V, Halliez S, Nishimaru H, Wilbertz J, Arenas E, Koltzenburg M, Charnay P, El Manira A, Ibañez CF, Ernfors P
Nature. 2008
PubMed ID: 18185516

Copy number alterations of the H2AFX gene in sporadic breast cancer patients.
Srivastava N, Gochhait S, Gupta P, Bamezai RN
Cancer Genet Cytogenet. 2008
PubMed ID: 18206537

Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells.
Susanto J, Lin YH, Chen YN, Shen CR, Yan YT, Tsai ST, Chen CH, Shen CN
PLoS ONE. 2008
PubMed ID: 19107196

Analysis of variants in DNA damage signalling genes in bladder cancer.
Choudhury A, Elliott F, Iles MM, Churchman M, Bristow RG, Bishop DT, Kiltie AE
BMC Med Genet. 2008
PubMed ID: 18638378

The sticky business of histone H2AX in V(D)J recombination, maintenance of genomic stability, and suppression of lymphoma.
Yin B, Bassing CH
Immunol Res. 2008
PubMed ID: 18622584

Soluble histone H2AX is induced by DNA replication stress and sensitizes cells to undergo apoptosis.
Liu Y, Parry JA, Chin A, Duensing S, Duensing A
Mol Cancer. 2008
PubMed ID: 18616816

Deregulated E2f-2 underlies cell cycle and maturation defects in retinoblastoma null erythroblasts.
Dirlam A, Spike BT, Macleod KF
Mol Cell Biol. 2007
PubMed ID: 17923680

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly.
Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J
Cell. 2007
PubMed ID: 18001825

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J
Cell. 2007
PubMed ID: 18001824

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
Wood JL, Singh N, Mer G, Chen J
J Biol Chem. 2007
PubMed ID: 17925396

Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
Koike M, Mashino M, Sugasawa J, Koike A
Biochem Biophys Res Commun. 2007
PubMed ID: 17923115

The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes.
Medina R, van der Deen M, Miele-Chamberland A, Xie RL, van Wijnen AJ, Stein JL, Stein GS
Cancer Res. 2007
PubMed ID: 17974976

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
Ikura T, Tashiro S, Kakino A, Shima H, Jacob N, Amunugama R, Yoder K, Izumi S, Kuraoka I, Tanaka K, Kimura H, Ikura M, Nishikubo S, Ito T, Muto A, Miyagawa K, Takeda S, Fishel R, Igarashi K, Kamiya K
Mol Cell Biol. 2007
PubMed ID: 17709392

Werner syndrome helicase (WRN), nuclear DNA helicase II (NDH II) and histone gammaH2AX are localized to the centrosome.
Zhang S, Hemmerich P, Grosse F
Cell Biol Int. 2007
PubMed ID: 17498979

Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.
Li XC, Li X, Schimenti JC
PLoS Genet. 2007
PubMed ID: 17696610

Expression analysis of the mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr), reveals that Xmr encodes a spermatid-expressed cytoplasmic protein, SLX/XMR.
Reynard LN, Turner JM, Cocquet J, Mahadevaiah SK, Touré A, Höög C, Burgoyne PS
Biol Reprod. 2007
PubMed ID: 17475928

Functional dynamics of H3K9 methylation during meiotic prophase progression.
Tachibana M, Nozaki M, Takeda N, Shinkai Y
EMBO J. 2007
PubMed ID: 17599069

Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals.
Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE
J Cell Biol. 2007
PubMed ID: 17635934

Endogenous gamma-H2AX-ATM-Chk2 checkpoint activation in Bloom's syndrome helicase deficient cells is related to DNA replication arrested forks.
Rao VA, Conti C, Guirouilh-Barbat J, Nakamura A, Miao ZH, Davies SL, Saccá B, Hickson ID, Bensimon A, Pommier Y
Mol Cancer Res. 2007
PubMed ID: 17634426

Water soluble fraction of solar-simulated light-exposed crude oil generates phosphorylation of histone H2AX in human skin cells under UVA exposure.
Ibuki Y, Toyooka T, Shirahata J, Ohura T, Goto R
Environ Mol Mutagen. 2007
PubMed ID: 17372987

Deficiency in the response to DNA double-strand breaks in mouse early preimplantation embryos.
Yukawa M, Oda S, Mitani H, Nagata M, Aoki F
Biochem Biophys Res Commun. 2007
PubMed ID: 17498656

Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma.
Novik KL, Spinelli JJ, Macarthur AC, Shumansky K, Sipahimalani P, Leach S, Lai A, Connors JM, Gascoyne RD, Gallagher RP, Brooks-Wilson AR
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17548670

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ
Science. 2007
PubMed ID: 17525332

Detection of phosphorylated histone H2AX in differentiated cells after X-ray irradiation.
Gavrilov BA, Firsanov DV, Vezhenkova IV, Solov'eva LV, Mikhailov VM, Tomilin NB
Dokl Biol Sci. 2007
PubMed ID: 17668632

Heat shock does not induce gammaH2AX foci formation but protects cells from N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity.
Dong Z, Hu H, Chen W, Li Z, Liu G, Yang J
Mutat Res. 2007
PubMed ID: 17276133

Maternal microRNAs are essential for mouse zygotic development.
Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA
Genes Dev. 2007
PubMed ID: 17369397

Initiation and resolution of interhomolog connections: crossover and non-crossover sites along mouse synaptonemal complexes.
Moens PB, Marcon E, Shore JS, Kochakpour N, Spyropoulos B
J Cell Sci. 2007
PubMed ID: 17344431

Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells.
Matsumoto M, Yaginuma K, Igarashi A, Imura M, Hasegawa M, Iwabuchi K, Date T, Mori T, Ishizaki K, Yamashita K, Inobe M, Matsunaga T
J Cell Sci. 2007
PubMed ID: 17327276

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability.
Bogliolo M, Lyakhovich A, Callén E, Castellà M, Cappelli E, Ramírez MJ, Creus A, Marcos R, Kalb R, Neveling K, Schindler D, Surrallés J
EMBO J. 2007
PubMed ID: 17304220

DDB1 is essential for genomic stability in developing epidermis.
Cang Y, Zhang J, Nicholas SA, Kim AL, Zhou P, Goff SP
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17301228

ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells.
Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM
Oncogene. 2007
PubMed ID: 16909103

Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes.
Tanaka T, Kajstura M, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Prolif. 2007
PubMed ID: 17227291

Attenuation of genotoxicity under adhesion-restrictive conditions through modulation of p53, gamma H2AX and nuclear DNA organization.
Strasberg Rieber M, Viola-Rhenals M, Rieber M
Apoptosis. 2007
PubMed ID: 17203247

gammaH2AX foci form preferentially in euchromatin after ionising-radiation.
Cowell IG, Sunter NJ, Singh PB, Austin CA, Durkacz BW, Tilby MJ
PLoS ONE. 2007
PubMed ID: 17957241

Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss.
Paul C, Povey JE, Lawrence NJ, Selfridge J, Melton DW, Saunders PT
PLoS ONE. 2007
PubMed ID: 17912366

Inhibition of transcription at radiation-induced nuclear foci of phosphorylated histone H2AX in mammalian cells.
Solovjeva LV, Svetlova MP, Chagin VO, Tomilin NV
Chromosome Res. 2007
PubMed ID: 17874213

ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.
Tanaka T, Huang X, Jorgensen E, Gietl D, Traganos F, Darzynkiewicz Z, Albino AP
BMC Cell Biol. 2007
PubMed ID: 17594478

Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells.
Zykova TA, Zhu F, Lu C, Higgins L, Tatsumi Y, Abe Y, Bode AM, Dong Z
Clin Cancer Res. 2006
PubMed ID: 17145805

In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication.
Baltus AE, Menke DB, Hu YC, Goodheart ML, Carpenter AE, de Rooij DG, Page DC
Nat Genet. 2006
PubMed ID: 17115059

DNA damage-induced RPA focalization is independent of gamma-H2AX and RPA hyper-phosphorylation.
Liu JS, Kuo SR, Melendy T
J Cell Biochem. 2006
PubMed ID: 16927366

H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy.
Bewersdorf J, Bennett BT, Knight KL
Proc Natl Acad Sci U S A. 2006
PubMed ID: 17110439

Oxidative stress induces H2AX phosphorylation in human spermatozoa.
Li Z, Yang J, Huang H
FEBS Lett. 2006
PubMed ID: 17064697

Phosphorylation of histone H2AX on Ser 139 and activation of ATM during oxidative burst in phorbol ester-treated human leukocytes.
Tanaka T, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Cycle. 2006
PubMed ID: 17106266

Slow elimination of phosphorylated histone gamma-H2AX from DNA of terminally differentiated mouse heart cells in situ.
Gavrilov B, Vezhenkova I, Firsanov D, Solovjeva L, Svetlova M, Mikhailov V, Tomilin N
Biochem Biophys Res Commun. 2006
PubMed ID: 16857171

Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.
Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, Imbalzano AN, Kwon J
EMBO J. 2006
PubMed ID: 16932743

Levels of gamma-H2AX Foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two at families and in another apparently normal individual.
Kato TA, Nagasawa H, Weil MM, Little JB, Bedford JS
Radiat Res. 2006
PubMed ID: 16953663

Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status.
Tanaka T, Kurose A, Huang X, Traganos F, Dai W, Darzynkiewicz Z
Cell Prolif. 2006
PubMed ID: 16872365

Constitutive histone H2AX phosphorylation on Ser-139 in cells untreated by genotoxic agents is cell-cycle phase specific and attenuated by scavenging reactive oxygen species.
Huang X, Tanaka T, Kurose A, Traganos F, Darzynkiewicz Z
Int J Oncol. 2006
PubMed ID: 16820894

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa.
Neuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H
J Cell Sci. 2006
PubMed ID: 16820410

H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks.
Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16788066

gamma-H2AX formation in response to interstrand crosslinks requires XPF in human cells.
Mogi S, Oh DH
DNA Repair (Amst). 2006
PubMed ID: 16678501

The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest.
Du YC, Gu S, Zhou J, Wang T, Cai H, Macinnes MA, Bradbury EM, Chen X
Mol Cell Proteomics. 2006
PubMed ID: 16522924

2-deoxy-D-glucose reduces the level of constitutive activation of ATM and phosphorylation of histone H2AX.
Tanaka T, Kurose A, Halicka HD, Traganos F, Darzynkiewicz Z
Cell Cycle. 2006
PubMed ID: 16628006

FGF9 promotes survival of germ cells in the fetal testis.
DiNapoli L, Batchvarov J, Capel B
Development. 2006
PubMed ID: 16540514

H2AX is not affected in mantle cell lymphoma with 11q23 deletion.
Guikema JE, de Boer-Bergsma RW, Akkermans K, Schuuring E, Kluin PM
Genes Chromosomes Cancer. 2006
PubMed ID: 16382446

Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC
Nature. 2006
PubMed ID: 16400328

Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation.
Han J, Hendzel MJ, Allalunis-Turner J
Radiat Res. 2006
PubMed ID: 16494516

Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation.
Suzuki M, Suzuki K, Kodama S, Watanabe M
Radiat Res. 2006
PubMed ID: 16494514

ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis.
Tanaka T, Kurose A, Huang X, Dai W, Darzynkiewicz Z
Cell Prolif. 2006
PubMed ID: 16426422

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.
Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW
Mol Cell. 2006
PubMed ID: 16427010

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J
Mol Cell. 2006
PubMed ID: 16427009

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.
Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP
Cell. 2005
PubMed ID: 16377563

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.
Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J
Mol Cell. 2005
PubMed ID: 16310392

Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.
Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen BP, Chen DJ, Lilge L, Prise KM, Bazett Jones DP, Bristow RG
Cancer Res. 2005
PubMed ID: 16322227

Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo.
Lai M, Zimmerman ES, Planelles V, Chen J
J Virol. 2005
PubMed ID: 16306615

BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation.
Chadwick BP, Lane TF
Chromosoma. 2005
PubMed ID: 16240122

A histone H3 methyltransferase controls epigenetic events required for meiotic prophase.
Hayashi K, Yoshida K, Matsui Y
Nature. 2005
PubMed ID: 16292313

Phosphorylation of histone H2AX at M phase in human cells without DNA damage response.
Ichijima Y, Sakasai R, Okita N, Asahina K, Mizutani S, Teraoka H
Biochem Biophys Res Commun. 2005
PubMed ID: 16153602

Nucleophosmin is required for DNA integrity and p19Arf protein stability.
Colombo E, Bonetti P, Lazzerini Denchi E, Martinelli P, Zamponi R, Marine JC, Helin K, Falini B, Pelicci PG
Mol Cell Biol. 2005
PubMed ID: 16199867

ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells.
McManus KJ, Hendzel MJ
Mol Biol Cell. 2005
PubMed ID: 16030261

Novel genotoxicity assays identify norethindrone to activate p53 and phosphorylate H2AX.
Gallmeier E, Winter JM, Cunningham SC, Kahn SR, Kern SE
Carcinogenesis. 2005
PubMed ID: 15905198

DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions.
Reitsema T, Klokov D, Banáth JP, Olive PL
DNA Repair (Amst). 2005
PubMed ID: 16046194

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070

Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073

The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072

Foxl2 is required for commitment to ovary differentiation.
Ottolenghi C, Omari S, Garcia-Ortiz JE, Uda M, Crisponi L, Forabosco A, Pilia G, Schlessinger D
Hum Mol Genet. 2005
PubMed ID: 15944199

Global phosphoproteome of HT-29 human colon adenocarcinoma cells.
Kim JE, Tannenbaum SR, White FM
J Proteome Res. 2005
PubMed ID: 16083285

Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility.
Spiridonov NA, Wong L, Zerfas PM, Starost MF, Pack SD, Paweletz CP, Johnson GR
Mol Cell Biol. 2005
PubMed ID: 15870294

Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
Warters RL, Adamson PJ, Pond CD, Leachman SA
J Invest Dermatol. 2005
PubMed ID: 15816840

Heat shock induces phosphorylation of histone H2AX in mammalian cells.
Kaneko H, Igarashi K, Kataoka K, Miura M
Biochem Biophys Res Commun. 2005
PubMed ID: 15707990

Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II.
Mischo HE, Hemmerich P, Grosse F, Zhang S
J Biol Chem. 2005
PubMed ID: 15613478

Werner syndrome protein associates with gamma H2AX in a manner that depends upon Nbs1.
Cheng WH, Sakamoto S, Fox JT, Komatsu K, Carney J, Bohr VA
FEBS Lett. 2005
PubMed ID: 15733840

Vigilins bind to promiscuously A-to-I-edited RNAs and are involved in the formation of heterochromatin.
Wang Q, Zhang Z, Blackwell K, Carmichael GG
Curr Biol. 2005
PubMed ID: 15723802

Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis.
Baarends WM, Wassenaar E, van der Laan R, Hoogerbrugge J, Sleddens-Linkels E, Hoeijmakers JH, de Boer P, Grootegoed JA
Mol Cell Biol. 2005
PubMed ID: 15657431

Histone H2AX phosphorylation after cell irradiation with UV-B: relationship to cell cycle phase and induction of apoptosis.
Halicka HD, Huang X, Traganos F, King MA, Dai W, Darzynkiewicz Z
Cell Cycle. 2005
PubMed ID: 15655354

Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors.
Wang H, Wang M, Wang H, Böcker W, Iliakis G
J Cell Physiol. 2005
PubMed ID: 15389585

Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.
Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y
Mol Cell Biol. 2005
PubMed ID: 15632067

Silencing of unsynapsed meiotic chromosomes in the mouse.
Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS
Nat Genet. 2005
PubMed ID: 15580272

Control of sister chromatid recombination by histone H2AX.
Xie A, Puget N, Shim I, Odate S, Jarzyna I, Bassing CH, Alt FW, Scully R
Mol Cell. 2004
PubMed ID: 15610743

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species.
Kurz EU, Douglas P, Lees-Miller SP
J Biol Chem. 2004
PubMed ID: 15489221

NIMA-related protein kinase 1 is involved early in the ionizing radiation-induced DNA damage response.
Polci R, Peng A, Chen PL, Riley DJ, Chen Y
Cancer Res. 2004
PubMed ID: 15604234

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.
Turner JM, Aprelikova O, Xu X, Wang R, Kim S, Chandramouli GV, Barrett JC, Burgoyne PS, Deng CX
Curr Biol. 2004
PubMed ID: 15589157

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.
Riballo E, Kühne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Löbrich M
Mol Cell. 2004
PubMed ID: 15574327

ATM is required for efficient recombination between immunoglobulin switch regions.
Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC
J Exp Med. 2004
PubMed ID: 15520243

Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.
Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V
Mol Cell Biol. 2004
PubMed ID: 15485898

Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.
Hao LY, Strong MA, Greider CW
J Biol Chem. 2004
PubMed ID: 15322096

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation.
MacLaren A, Black EJ, Clark W, Gillespie DA
Mol Cell Biol. 2004
PubMed ID: 15456874

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC
J Cell Biol. 2004
PubMed ID: 15364958

Genomic analysis of mouse retinal development.
Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL
PLoS Biol. 2004
PubMed ID: 15226823

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch.
Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, Honjo T
Science. 2004
PubMed ID: 15326357

H2AX: the histone guardian of the genome.
Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A
DNA Repair (Amst). 2004
PubMed ID: 15279782

Gamma-H2AX expression pattern in non-irradiated neonatal mouse germ cells and after low-dose gamma-radiation: relationships between chromatid breaks and DNA double-strand breaks.
Forand A, Dutrillaux B, Bernardino-Sgherri J
Biol Reprod. 2004
PubMed ID: 15115728

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J
EMBO J. 2004
PubMed ID: 15201865

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Herbig U, Jobling WA, Chen BP, Chen DJ, Sedivy JM
Mol Cell. 2004
PubMed ID: 15149599

Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
Lee JH, Paull TT
Science. 2004
PubMed ID: 15064416

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA
Cancer Res. 2004
PubMed ID: 15059890

Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822

Quantitative trait Loci specifying the response of body temperature to dietary restriction.
Rikke BA, Yerg JE, Battaglia ME, Nagy TR, Allison DB, Johnson TE
J Gerontol A Biol Sci Med Sci. 2004
PubMed ID: 14999024

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis.
Kuramochi-Miyagawa S, Kimura T, Ijiri TW, Isobe T, Asada N, Fujita Y, Ikawa M, Iwai N, Okabe M, Deng W, Lin H, Matsuda Y, Nakano T
Development. 2004
PubMed ID: 14736746

Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.
Lusic M, Marcello A, Cereseto A, Giacca M
EMBO J. 2003
PubMed ID: 14657027

DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.
Park EJ, Chan DW, Park JH, Oettinger MA, Kwon J
Nucleic Acids Res. 2003
PubMed ID: 14627815

Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads.
Yao HH, DiNapoli L, Capel B
Development. 2003
PubMed ID: 14561636

Absence of mDazl produces a final block on germ cell development at meiosis.
Saunders PT, Turner JM, Ruggiu M, Taggart M, Burgoyne PS, Elliott D, Cooke HJ
Reproduction. 2003
PubMed ID: 14611631

H2AX regulates meiotic telomere clustering.
Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A
J Cell Biol. 2003
PubMed ID: 14530383

NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.
Xu X, Stern DF
FASEB J. 2003
PubMed ID: 14519663

DNA damage induced by polyglutamine-expanded proteins.
Giuliano P, De Cristofaro T, Affaitati A, Pizzulo GM, Feliciello A, Criscuolo C, De Michele G, Filla A, Avvedimento EV, Varrone S
Hum Mol Genet. 2003
PubMed ID: 12915485

Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.
Nazarov IB, Smirnova AN, Krutilina RI, Svetlova MP, Solovjeva LV, Nikiforov AA, Oei SL, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV
Radiat Res. 2003
PubMed ID: 12926989

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.
Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A
Cell. 2003
PubMed ID: 12914701

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, Gleason M, Bronson R, Lee C, Alt FW
Cell. 2003
PubMed ID: 12914700

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A
Nat Cell Biol. 2003
PubMed ID: 12792649

H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation.
Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC
J Exp Med. 2003
PubMed ID: 12810694

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.
Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM
Biochem Cell Biol. 2003
PubMed ID: 12897845

Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
Ward IM, Minn K, Jorda KG, Chen J
J Biol Chem. 2003
PubMed ID: 12697768

Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y
J Biol Chem. 2003
PubMed ID: 12660252

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.
Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A
Dev Cell. 2003
PubMed ID: 12689589

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage.
Peng A, Chen PL
J Biol Chem. 2003
PubMed ID: 12551934

Expression and radiation-induced phosphorylation of histone H2AX in mammalian cells.
Yoshida K, Yoshida SH, Shimoda C, Morita T
J Radiat Res (Tokyo). 2003
PubMed ID: 12841599

MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature. 2003
PubMed ID: 12607005

DNA double-strand breaks and gamma-H2AX signaling in the testis.
Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, de Rooij DG
Biol Reprod. 2003
PubMed ID: 12533428

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Bakkenist CJ, Kastan MB
Nature. 2003
PubMed ID: 12556884

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains.
Mallery DL, Vandenberg CJ, Hiom K
EMBO J. 2002
PubMed ID: 12485996

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A
Nat Cell Biol. 2002
PubMed ID: 12447390

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
Kobayashi J, Tauchi H, Sakamoto S, Nakamura A, Morishima K, Matsuura S, Kobayashi T, Tamai K, Tanimoto K, Komatsu K
Curr Biol. 2002
PubMed ID: 12419185

Photobleaching of GFP-labeled H2AX in chromatin: H2AX has low diffusional mobility in the nucleus.
Siino JS, Nazarov IB, Svetlova MP, Solovjeva LV, Adamson RH, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV
Biochem Biophys Res Commun. 2002
PubMed ID: 12372432

Mouse models of male infertility.
Cooke HJ, Saunders PT
Nat Rev Genet. 2002
PubMed ID: 12360237

End-joining of reconstituted histone H2AX-containing chromatin in vitro by soluble nuclear proteins from human cells.
Siino JS, Nazarov IB, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV
FEBS Lett. 2002
PubMed ID: 12220643

Mfrp, a gene encoding a frizzled related protein, is mutated in the mouse retinal degeneration 6.
Kameya S, Hawes NL, Chang B, Heckenlively JR, Naggert JK, Nishina PM
Hum Mol Genet. 2002
PubMed ID: 12140190

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase.
Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ
J Biol Chem. 2002
PubMed ID: 11927591

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.
Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12034884

Genomic instability in mice lacking histone H2AX.
Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A
Science. 2002
PubMed ID: 11934988

Residue-specific mass signatures for the efficient detection of protein modifications by mass spectrometry.
Zhu H, Hunter TC, Pan S, Yau PM, Bradbury EM, Chen X
Anal Chem. 2002
PubMed ID: 12033261

Histone H2A variants H2AX and H2AZ.
Redon C, Pilch D, Rogakou E, Sedelnikova O, Newrock K, Bonner W
Curr Opin Genet Dev. 2002
PubMed ID: 11893489

Hyperphosphorylation of histone H2A.X and dephosphorylation of histone H1 subtypes in the course of apoptosis.
Talasz H, Helliger W, Sarg B, Debbage PL, Puschendorf B, Lindner H
Cell Death Differ. 2002
PubMed ID: 11803372

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
Ward IM, Chen J
J Biol Chem. 2001
PubMed ID: 11673449

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.
Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A
Nature. 2001
PubMed ID: 11740565

ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ
J Biol Chem. 2001
PubMed ID: 11571274

Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.
Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, Donnelly R, Wade JD, Lambert P, Kashanchi F
Virology. 2001
PubMed ID: 11689053

Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant.
Chadwick BP, Willard HF
Hum Mol Genet. 2001
PubMed ID: 11331621

Recombinational DNA double-strand breaks in mice precede synapsis.
Mahadevaiah SK, Turner JM, Baudat F, Rogakou EP, de Boer P, Blanco-Rodríguez J, Jasin M, Keeney S, Bonner WM, Burgoyne PS
Nat Genet. 2001
PubMed ID: 11242108

Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851

Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.
Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A
Science. 2000
PubMed ID: 11110662

Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.
Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, Lambert P, Li H, Lee CG, Kashanchi F
Virology. 2000
PubMed ID: 11080476

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.
Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM
Curr Biol. 2000
PubMed ID: 10959836

Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139.
Rogakou EP, Nieves-Neira W, Boon C, Pommier Y, Bonner WM
J Biol Chem. 2000
PubMed ID: 10734083

Megabase chromatin domains involved in DNA double-strand breaks in vivo.
Rogakou EP, Boon C, Redon C, Bonner WM
J Cell Biol. 1999
PubMed ID: 10477747

High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636

Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.
El Kharroubi A, Piras G, Zensen R, Martin MA
Mol Cell Biol. 1998
PubMed ID: 9566873

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM
J Biol Chem. 1998
PubMed ID: 9488723

Regulation of the mouse histone H2A.X gene promoter by the transcription factor E2F and CCAAT binding protein.
Yagi H, Kato T, Nagata T, Habu T, Nozaki M, Matsushiro A, Nishimune Y, Morita T
J Biol Chem. 1995
PubMed ID: 7642525

ATP-dependent reorganization of human sperm nuclear chromatin.
Banerjee S, Smallwood A, Hultén M
J Cell Sci. 1995
PubMed ID: 7769017

Structure of the mouse H2A.X gene and physical linkage to the UPS locus on chromosome 9: assignment of the human H2A.X gene to 11q23 by sequence analysis.
Porcher C, Grandchamp B
Genomics. 1995
PubMed ID: 7774939

Characterization of the human histone H2A.X gene. Comparison of its promoter with other H2A gene promoters.
Ivanova VS, Hatch CL, Bonner WM
J Biol Chem. 1994
PubMed ID: 7929075

Chromosomal localization of the human histone H2A.X gene to 11q23.2-q23.3 by fluorescence in situ hybridization.
Ivanova VS, Zimonjic D, Popescu N, Bonner WM
Hum Genet. 1994
PubMed ID: 8076949

Polyadenylated and 3' processed mRNAs are transcribed from the mouse histone H2A.X gene.
Nagata T, Kato T, Morita T, Nozaki M, Kubota H, Yagi H, Matsushiro A
Nucleic Acids Res. 1991
PubMed ID: 2041781

H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals.
Mannironi C, Bonner WM, Hatch CL
Nucleic Acids Res. 1989
PubMed ID: 2587254

Quantitative determination of histone modification. H2A acetylation and phosphorylation.
Pantazis P, Bonner WM
J Biol Chem. 1981
PubMed ID: 7217105

Histone 2A, a heteromorphous family of eight protein species.
West MH, Bonner WM
Biochemistry. 1980
PubMed ID: 7407044

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Human Mouse Rat

Entrez Gene 3014 15270 500987

EnsEMBL Gene(s) ENSG00000188486 ENSMUSG00000049932 ENSRNOG00000010386

Unigene Hs.477879 Mm.245931 Rn.2850

Homologene H2AFX H2afx H2afx

OMIM 601772 N/A N/A

GeneCards H2AFX N/A N/A

Beta Cell Genomics DT.40219073 DT.95318297 DT.101180324 DT.55282168 N/A

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Interactor	Interactor	Sources	Classification	Pubmed IDs
H2AFX	PDCD6	IntAct, BioGRID	empirical	20000738
H2AFX	RAD50	BioGRID	empirical	10959836 15201865
H2AFX	PDIA6	IntAct, BioGRID	empirical	20000738
H2AFX	TRAP1	IntAct, BioGRID	empirical	20000738
H2AFX	ALYREF	IntAct	empirical	20000738
H2AFX	HNRNPR	IntAct, BioGRID	empirical	20000738 16522924
H2AFX	SYNCRIP	IntAct, BioGRID	empirical	20000738
H2AFX	VAT1	IntAct, BioGRID	empirical	20000738
H2AFX	KAT5	BioGRID	empirical	18406329 20224553
H2AFX	HYOU1	IntAct, BioGRID	empirical	20000738
H2AFX	PRDX4	IntAct, BioGRID	empirical	20000738
H2AFX	CFL1	IntAct, BioGRID	empirical	20000738
H2AFX	PRDX3	IntAct	empirical	20000738
H2AFX	ERP29	IntAct, BioGRID	empirical	20000738
H2AFX	YWHAQ	BioGRID	empirical	20618440
H2AFX	SUPT16H	BioGRID	empirical	16522924 18406329
H2AFX	CLU	IntAct	empirical	20000738
H2AFX	MSI2	IntAct, BioGRID	empirical	20000738
H2AFX	APOA1BP	IntAct, BioGRID	empirical	20000738
H2AFX	CMBL	IntAct, BioGRID	empirical	20000738
H2AFX	CPS1	IntAct, BioGRID	empirical	20000738
H2AFX	PARP1	IntAct, BioGRID	empirical	20085707 20000738 16522924 18406329
H2AFX	CTSD	IntAct, BioGRID	empirical	20000738
H2AFX	RNF168	IntAct, BioGRID	empirical	19203578 19500350
H2AFX	DHX9	BioGRID	empirical	15613478
H2AFX	TOR1A	IntAct, BioGRID	empirical	20000738
H2AFX	EEF1A1	BioGRID	empirical	18406329
H2AFX	EEF1B2	IntAct, BioGRID	empirical	20000738
H2AFX	EIF4A1	IntAct, BioGRID	empirical	20000738
H2AFX	ELAVL1	IntAct, BioGRID	empirical	20000738
H2AFX	A2M	BioGRID	empirical	21900206
H2AFX	ENO1	IntAct, BioGRID	empirical	20000738
H2AFX	ESR1	IntAct	empirical	21182205
H2AFX	EYA3	BioGRID	empirical	19234442
H2AFX	FANCD2	MINT, BioGRID	empirical	17304220
H2AFX	ALDOA	IntAct, BioGRID	empirical	20000738
H2AFX	COPG1	BioGRID	empirical	21900206
H2AFX	DHX30	BioGRID	empirical	16522924
H2AFX	CCT5	IntAct, BioGRID	empirical	20000738
H2AFX	FOXO3	BioGRID	empirical	18344987
H2AFX	GANAB	IntAct, BioGRID	empirical	20000738
H2AFX	POFUT1	IntAct, BioGRID	empirical	20000738
H2AFX	XRCC6	BioGRID	empirical	15613478 18406329 20224553
H2AFX	CCDC19	BioGRID	empirical	20000738
H2AFX	SUMF2	IntAct, BioGRID	empirical	20000738
H2AFX	TIAM2	BioGRID	empirical	21900206
H2AFX	HIBCH	IntAct, BioGRID	empirical	20000738
H2AFX	KAT2A	BioGRID	empirical	20224553
H2AFX	PABPC1	IntAct, BioGRID	empirical	20000738 16522924
H2AFX	TAF5L	BioGRID	empirical	21900206
H2AFX	GLB1	IntAct	empirical	20000738
H2AFX	TOR1B	IntAct, BioGRID	empirical	20000738
H2AFX	SLC25A6	IntAct, BioGRID	empirical	20000738
H2AFX	ERO1L	IntAct, BioGRID	empirical	20000738
H2AFX	H2AFX	HPRD	empirical	14519663 16377563
H2AFX	ANXA2	IntAct, BioGRID	empirical	20000738
H2AFX	HSD17B10	IntAct	empirical	20000738
H2AFX	ANXA2P2	IntAct, BioGRID	empirical	20000738
H2AFX	ANXA4	IntAct, BioGRID	empirical	20000738
H2AFX	HEXA	IntAct, BioGRID	empirical	20000738
H2AFX	ANXA5	IntAct, BioGRID	empirical	20000738
H2AFX	ANXA6	IntAct, BioGRID	empirical	20000738
H2AFX	HNRNPA1	IntAct, BioGRID	empirical	20000738
H2AFX	HNRNPA2B1	IntAct, BioGRID	empirical	20000738
H2AFX	HNRNPAB	IntAct, BioGRID	empirical	20000738
H2AFX	HNRNPC	IntAct	empirical	20000738
H2AFX	HNRNPD	IntAct, BioGRID	empirical	20000738
H2AFX	HNRNPH3	IntAct, BioGRID	empirical	20000738
H2AFX	AIRE	IntAct	empirical	20085707
H2AFX	HSPA1L	IntAct, BioGRID	empirical	20000738
H2AFX	HSPA5	BioGRID	empirical	16522924
H2AFX	HSPA9	IntAct, BioGRID	empirical	20000738
H2AFX	BIRC5	BioGRID	empirical	20394854
H2AFX	HSP90AA1	IntAct, BioGRID	empirical	20000738
H2AFX	ILF2	IntAct, BioGRID	empirical	20000738
H2AFX	LDHB	IntAct, BioGRID	empirical	20000738
H2AFX	LGALS3BP	IntAct, BioGRID	empirical	20000738
H2AFX	LMNA	IntAct, BioGRID	empirical	20000738
H2AFX	ARRB1	IntAct	empirical	17620599
H2AFX	ARRB2	IntAct	empirical	17620599
H2AFX	MRE11A	HPRD, IntAct	empirical	12419185
H2AFX	MSN	IntAct, BioGRID	empirical	20000738
H2AFX	NACA	IntAct, BioGRID	empirical	20000738
H2AFX	NBN	HPRD, IntAct, BioGRID, Reactome	empirical	11110662 15733840 18001825 18001824 12419185 12792649 16932743 15201865
H2AFX	ATM	HPRD, MINT, BioGRID	empirical	9488723 11893489 11571274 16858402
H2AFX	NEDD8	BioGRID	empirical	18274552
H2AFX	NGFR	BioGRID	empirical	21900206
H2AFX	NONO	IntAct, BioGRID	empirical	20000738
H2AFX	NPM1	BioGRID	empirical	16522924
H2AFX	P4HB	IntAct, BioGRID	empirical	20000738
H2AFX	PAPPA	BioGRID	empirical	16522924
H2AFX	PCBP2	IntAct, BioGRID	empirical	20000738
H2AFX	TXNDC12	IntAct, BioGRID	empirical	20000738
H2AFX	FAM82B	IntAct	empirical	20000738
H2AFX	EIF3L	BioGRID	empirical	16522924
H2AFX	UIMC1	IntAct	empirical	18001824
H2AFX	PGK1	IntAct, BioGRID	empirical	20000738
H2AFX	PKM2	IntAct, BioGRID	empirical	20000738
H2AFX	PLOD1	IntAct, BioGRID	empirical	20000738
H2AFX	POLR2A	BioGRID	empirical	15613478
H2AFX	ATR	BioGRID	empirical	19805520
H2AFX	INO80	IntAct	empirical	19014934
H2AFX	PPIA	IntAct, BioGRID	empirical	20000738
H2AFX	PPM1G	BioGRID	empirical	18406329
H2AFX	PPP1CA	HPRD	empirical	12926989
H2AFX	PTCD3	BioGRID	empirical	16522924
H2AFX	PPP2R4	BioGRID	empirical	16310392
H2AFX	PEF1	IntAct, BioGRID	empirical	20000738
H2AFX	ABHD10	IntAct, BioGRID	empirical	20000738
H2AFX	OTUB1	BioGRID	empirical	21900206
H2AFX	NLRP2	MINT	empirical	15733840
H2AFX	VPS35	IntAct, BioGRID	empirical	20000738
H2AFX	PBK	BioGRID	empirical	17145805
H2AFX	PRKCSH	IntAct	empirical	20000738
H2AFX	PRKDC	IntAct, BioGRID	empirical	20085707 14627815 15613478 18406329 20356835
H2AFX	MAPK8	BioGRID	empirical	17145805 20512932
H2AFX	MASP1	BioGRID	empirical	21900206
H2AFX	PSMB3	IntAct, BioGRID	empirical	20000738
H2AFX	PSMB4	IntAct, BioGRID	empirical	20000738
H2AFX	BARD1	BioGRID	empirical	12485996 11927591
H2AFX	QARS	BioGRID	empirical	21900206
H2AFX	RAD17	BioGRID	empirical	18344987
H2AFX	RAD51	BioGRID	empirical	10959836
H2AFX	ACTB	BioGRID	empirical	21900206
H2AFX	FKBP10	IntAct, BioGRID	empirical	20000738
H2AFX	RPLP2	IntAct, BioGRID	empirical	20000738
H2AFX	RPN2	IntAct, BioGRID	empirical	20000738
H2AFX	RPS6KA3	BioGRID	empirical	21224359
H2AFX	RPS10	IntAct, BioGRID	empirical	20000738
H2AFX	S100A4	IntAct, BioGRID	empirical	20000738
H2AFX	BLM	BioGRID	empirical	15364958
H2AFX	LEPRE1	IntAct, BioGRID	empirical	20000738
H2AFX	BMI1	BioGRID	empirical	21383063
H2AFX	SMARCA2	BioGRID	empirical	16932743 20224553
H2AFX	SMARCA4	BioGRID	empirical	16932743 20224553
H2AFX	SOD2	IntAct, BioGRID	empirical	20000738
H2AFX	BRCA1	HPRD, IntAct, BioGRID	empirical	12419185 18001825 18001824 12485996 10959836 11927591 19805520 18344987
H2AFX	SSB	BioGRID	empirical	16522924
H2AFX	SSBP1	IntAct, BioGRID	empirical	20000738
H2AFX	SSRP1	BioGRID	empirical	16522924 18406329
H2AFX	SUPT5H	HPRD, IntAct	empirical	16169070
H2AFX	BTF3	IntAct, BioGRID	empirical	20000738
H2AFX	TKT	IntAct, BioGRID	empirical	20000738
H2AFX	TOP2A	IntAct	empirical	20085707
H2AFX	TP53	BioGRID	empirical	16322227
H2AFX	TP53BP1	HPRD, MINT, IntAct, BioGRID	empirical	12697768 12447390 17024177 18001824 18001825 12607005 15364958 12792649
H2AFX	HSP90B1	IntAct, BioGRID	empirical	20000738
H2AFX	UBB	IntAct	empirical	18001824
H2AFX	UBC	BioGRID	empirical	19850743 18781797 21383063 21878640 21139048 21890473 21906983
H2AFX	WRN	HPRD, MINT, BioGRID	empirical	15733840
H2AFX	XPC	BioGRID	empirical	19805520
H2AFX	XRCC5	IntAct, BioGRID	empirical	20085707 18406329
H2AFX	YWHAB	IntAct, BioGRID	empirical	20000738
H2AFX	YWHAE	IntAct, BioGRID	empirical	20000738
H2AFX	YWHAZ	IntAct, BioGRID	empirical	20000738
H2AFX	OBFC2B	IntAct	empirical	18449195
H2AFX	MCPH1	BioGRID	empirical	22154951
H2AFX	ALG9	HPRD	empirical	14519663
H2AFX	NHEJ1	MINT	empirical	18064046
H2AFX	ACTR5	IntAct	empirical	19014934
H2AFX	PTGES2	IntAct	empirical	20000738
H2AFX	CALR	IntAct, BioGRID	empirical	20000738 16522924
H2AFX	TMX1	BioGRID	empirical	20000738
H2AFX	TXNDC5	IntAct	empirical	20000738
H2AFX	HIST3H3	Reactome	predicted
H2AFX	HIST2H2AC	BioGRID	empirical	20224553
H2AFX	HIST1H2BM	BioGRID	empirical	16522924
H2AFX	HIST1H2BC	BioGRID	empirical	16522924
H2AFX	HIST2H2BE	BioGRID	empirical	16522924 20224553
H2AFX	HIST1H3A	BioGRID	empirical	20224553
H2AFX	HIST1H4A	BioGRID	empirical	16522924 20224553 20000738
H2AFX	TAGLN2	IntAct	empirical	20000738
H2AFX	KAT8	BioGRID	empirical	20224553
H2AFX	CBX2	BioGRID	empirical	21383063
H2AFX	PPM1D	BioGRID	empirical	20101220 20460517 20118229
H2AFX	HAT1	BioGRID	empirical	20224553
H2AFX	RUVBL1	BioGRID	empirical	18285460
H2AFX	KAT2B	BioGRID	empirical	20224553
H2AFX	EIF2S2	IntAct, BioGRID	empirical	20000738
H2AFX	P4HA2	IntAct, BioGRID	empirical	20000738
H2AFX	TAF1C	BioGRID	empirical	21900206
H2AFX	RNF8	IntAct	empirical	18001824 18001825
H2AFX	AIFM1	IntAct, BioGRID	empirical	20000738 20360685
H2AFX	RAB11B	IntAct, BioGRID	empirical	20000738
H2AFX	TP53I3	BioGRID	empirical	20023697
H2AFX	CHD1L	BioGRID	empirical	19666485
H2AFX	PRDX6	IntAct	empirical	20000738
H2AFX	PDIA4	IntAct, BioGRID	empirical	20000738
H2AFX	MDC1	HPRD, IntAct, BioGRID, Reactome	empirical	14519663 12607005 18001825 18001824 15201865 21622030
H2AFX	MATR3	IntAct, BioGRID	empirical	20000738
H2AFX	HNRPDL	IntAct, BioGRID	empirical	20000738