IL19
| Gene Description: |
interleukin 19 |
| Synonyms: |
ZMDA1, IL19, IL-10C, Il19, NG.1, MDA1 |
| Orthologs: |
Human IL19 (protein-coding), Mouse Il19 (protein-coding), Rat Il19 (protein-coding)
|
| |
|
Sources
Sources
|
Human-Mouse:
|
HomoloGene, MGD, RGD
|
|
Human-Rat:
|
HomoloGene, MGD, RGD
|
|
Mouse-Rat:
|
HomoloGene, MGD, RGD
|
|
Possible sources:
|
HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG
|
|
|
|
Regions of Interest Overlapping this feature from T1DBase
Top
Help
Regions Overlapping this Feature:
Human: 1
Mouse: 3
Rat: 1
Associated Regions: Available
Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.
Linkage Regions: Available
Other Regions: Available
Gene Overview from T1DBase
Top
Help
Beta Cell Gene Atlas from T1DBase
Top
Help
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
|
| |
|
|
|
no data |
|
no data |
no data |
no data |
no data |
no data |
no data |
no data |
no data |
|
|
Expression Legend
|
|
|
|
The Beta Cell Gene Atlas is a collection of almost all available public microarray
data generated with pancreatic beta cells and related cell lines and types. The
expression data comes from 131 array analyses derived from 28 experiments
(open details in a new window).
The basal (untreated cell) expression signal intensity values in each array
were converted to ranks within the experiments; the highest value was used for
genes represented by more than one probe. The rank values of genes in a given cell
type were averaged with other calculated values from experiments performed with the
same cell type. The rank transformation of the expression values enable comparison
of gene expression across different organisms and tissues.
|
|
A red border around a cell indicates greater certainty in the data;
specifically, the gene has >0.95 probability of being expressed in the tissue.
|
|
| Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
|
| |
|
|
|
Expression Legend
|
|
|
|
Signal intensity values were converted to ranks within the experiments.
For genes represented by more than one probeset, we averaged the intensity
signals for each probeset across all tissues and chose the probeset with the
highest average value. The rank transformation of the expression values enables
comparison of gene expression across different organisms and tissues.
|
Interactions Table for IL19:
The IL19 interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor |
Interactor |
Sources |
Classification |
Pubmed IDs |
| IL19 |
IL20RA |
HPRD |
empirical |
11564763
|
|
Cross-Reference to Pathways and GO Terms
Top
Help
|
|
View all
|
|
|
|
KEGG Network: 2
|
| |
|
|
|
|
Biocarta: None available
|
| |
|
|
|
|
Reactome: None available
|
| |
|
|
|
|
NCI-Nature Pathway Interaction Database: 1
|
| |
|
|
|
|
Gene Ontology: 9
|
| |
|
|
Type 1 Diabetes Publications: 1
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
Barrett JC, Clayton DG, Concannon P, Akolkar B, Cooper JD, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Plagnol V, Pociot F, Schuilenburg H, Smyth DJ, Stevens H, Todd JA, Walker NM, Rich SS, The Type 1 Diabetes Genetics Consortium
Nat Genet. 2009
PubMed ID: 19430480
Publications: 56
-
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagacé C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lémann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panés J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD
Nat Genet. 2011
PubMed ID: 21297633
-
The anti-inflammatory cytokine interleukin 19 is expressed by and angiogenic for human endothelial cells.
Jain S, Gabunia K, Kelemen SE, Panetti TS, Autieri MV
Arterioscler Thromb Vasc Biol. 2011
PubMed ID: 20966397
-
Investigation of genetic susceptibility factors for human longevity - A targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A
Mutat Res. 2010
PubMed ID: 20800603
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M
Nat Genet. 2010
PubMed ID: 21102463
-
Adaptive immune response in osteoclastic bone resorption induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease.
Li Y, Messina C, Bendaoud M, Fine DH, Schreiner H, Tsiagbe VK
Mol Oral Microbiol. 2010
PubMed ID: 20618701
-
Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism.
Beckers MM, Ruven HJ, Haas FJ, Doevendans PA, ten Cate H, Prins MH, Biesma DH
Eur J Intern Med. 2010
PubMed ID: 20603037
-
Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
Lee KM, Baris D, Zhang Y, Hosgood HD, Menashe I, Yeager M, Zahm SH, Wang SS, Purdue MP, Chanock S, Zheng T, Rothman N, Lan Q
Am J Hematol. 2010
PubMed ID: 20568250
-
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
-
Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R
Pediatr Pulmonol. 2010
PubMed ID: 20503287
-
Interleukin-19 protects mice from innate-mediated colonic inflammation.
Azuma YT, Matsuo Y, Kuwamura M, Yancopoulos GD, Valenzuela DM, Murphy AJ, Nakajima H, Karow M, Takeuchi T
Inflamm Bowel Dis. 2010
PubMed ID: 19834971
-
New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
-
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
McGovern DP, Gardet A, Törkvist L, Goyette P, Essers J, Taylor KD, Neale BM, Ong RT, Lagacé C, Li C, Green T, Stevens CR, Beauchamp C, Fleshner PR, Carlson M, D'Amato M, Halfvarson J, Hibberd ML, Lördal M, Padyukov L, Andriulli A, Colombo E, Latiano A, Palmieri O, Bernard EJ, Deslandres C, Hommes DW, de Jong DJ, Stokkers PC, Weersma RK, NIDDK IBD Genetics Consortium, Sharma Y, Silverberg MS, Cho JH, Wu J, Roeder K, Brant SR, Schumm LP, Duerr RH, Dubinsky MC, Glazer NL, Haritunians T, Ippoliti A, Melmed GY, Siscovick DS, Vasiliauskas EA, Targan SR, Annese V, Wijmenga C, Pettersson S, Rotter JI, Xavier RJ, Daly MJ, Rioux JD, Seielstad M
Nat Genet. 2010
PubMed ID: 20228799
-
Interleukin 10 family gene polymorphisms are not associated with major depressive disorder and panic disorder phenotypes.
Koido K, Eller T, Kingo K, Kõks S, Traks T, Shlik J, Vasar V, Vasar E, Maron E
J Psychiatr Res. 2010
PubMed ID: 19786281
-
Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents.
Shrestha S, Wiener HW, Aissani B, Song W, Shendre A, Wilson CM, Kaslow RA, Tang J
PLoS One. 2010
PubMed ID: 20976276
-
Host genetic factors and vaccine-induced immunity to HBV infection: haplotype analysis.
Ryckman KK, Fielding K, Hill AV, Mendy M, Rayco-Solon P, Sirugo G, van der Sande MA, Waight P, Whittle HC, Hall AJ, Williams SM, Hennig BJ
PLoS One. 2010
PubMed ID: 20806065
-
Association analysis of genes of the IL19 cluster and their receptors in vitiligo patients.
Kingo K, Reimann E, Karelson M, Rätsep R, Raud K, Vasar E, Silm H, Kõks S
Dermatology. 2010
PubMed ID: 20699607
-
Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q
Occup Environ Med. 2009
PubMed ID: 19773279
-
Common genetic variants in candidate genes and risk of familial lymphoid malignancies.
Liang XS, Caporaso N, McMaster ML, Ng D, Landgren O, Yeager M, Chanock S, Goldin LR
Br J Haematol. 2009
PubMed ID: 19573080
-
Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R
Pediatr Infect Dis J. 2009
PubMed ID: 19258923
-
The distribution of interleukin-19 in healthy and neoplastic tissue.
Hsing CH, Li HH, Hsu YH, Ho CL, Chuang SS, Lan KM, Chang MS
Cytokine. 2008
PubMed ID: 18809337
-
Expression and suppressive effects of interleukin-19 on vascular smooth muscle cell pathophysiology and development of intimal hyperplasia.
Tian Y, Sommerville LJ, Cuneo A, Kelemen SE, Autieri MV
Am J Pathol. 2008
PubMed ID: 18669613
-
Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome.
Truelove AL, Oleksyk TK, Shrestha S, Thio CL, Goedert JJ, Donfield SM, Kirk GD, Thomas DL, O'Brien SJ, Smith MW
Int J Immunogenet. 2008
PubMed ID: 18479293
-
Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis.
Sellick GS, Wade R, Richards S, Oscier DG, Catovsky D, Houlston RS
Blood. 2008
PubMed ID: 18006695
-
Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.
Traks T, Koido K, Eller T, Maron E, Kingo K, Vasar V, Vasar E, Kõks S
BMC Med Genet. 2008
PubMed ID: 19087313
-
IL-19 is involved in the pathogenesis of endotoxic shock.
Hsing CH, Chiu CJ, Chang LY, Hsu CC, Chang MS
Shock. 2008
PubMed ID: 18246602
-
Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B
J Infect Dis. 2007
PubMed ID: 17703412
-
Expression of IL-19 correlates with Th2 cytokines in uraemic patients.
Hsing CH, Hsu CC, Chen WY, Chang LY, Hwang JC, Chang MS
Nephrol Dial Transplant. 2007
PubMed ID: 17449492
-
Association of interleukin-19 gene polymorphisms with age.
Okayama N, Suehiro Y, Hamanaka Y, Nakamura J, Hinoda Y
J Gerontol A Biol Sci Med Sci. 2007
PubMed ID: 17522354
-
IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases.
Sabat R, Wallace E, Endesfelder S, Wolk K
Expert Opin Ther Targets. 2007
PubMed ID: 17465720
-
Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis.
Kingo K, Mössner R, Kõks S, Rätsep R, Krüger U, Vasar E, Reich K, Silm H
Br J Dermatol. 2007
PubMed ID: 17263806
-
Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs.
Kunz S, Wolk K, Witte E, Witte K, Doecke WD, Volk HD, Sterry W, Asadullah K, Sabat R
Exp Dermatol. 2006
PubMed ID: 17083366
-
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, Gorman DM, Smith K, de Waal Malefyt R, Kastelein RA, McClanahan TK, Bowman EP
J Exp Med. 2006
PubMed ID: 17074928
-
A2B adenosine receptors induce IL-19 from bronchial epithelial cells, resulting in TNF-alpha increase.
Zhong H, Wu Y, Belardinelli L, Zeng D
Am J Respir Cell Mol Biol. 2006
PubMed ID: 16778150
-
Promoter analysis of interleukin 19.
Chen PJ, Wei CC, Wang C, Chen FW, Hsu YH, Chang MS
Biochem Biophys Res Commun. 2006
PubMed ID: 16631120
-
The DNA sequence and biological annotation of human chromosome 1.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E
Nature. 2006
PubMed ID: 16710414
-
Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance.
Oleksyk TK, Thio CL, Truelove AL, Goedert JJ, Donfield SM, Kirk GD, Thomas DL, O'Brien SJ, Smith MW
Genes Immun. 2005
PubMed ID: 15815689
-
Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.
Jordan WJ, Eskdale J, Boniotto M, Lennon GP, Peat J, Campbell JD, Gallagher G
Eur J Immunol. 2005
PubMed ID: 15827959
-
Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice.
Mesplès B, Fontaine RH, Lelièvre V, Launay JM, Gressens P
Neurobiol Dis. 2005
PubMed ID: 15649710
-
Proliferative activity of extracellular HIV-1 Tat protein in human epithelial cells: expression profile of pathogenetically relevant genes.
Bettaccini AA, Baj A, Accolla RS, Basolo F, Toniolo AQ
BMC Microbiol. 2005
PubMed ID: 15857508
-
IL-19 induced Th2 cytokines and was up-regulated in asthma patients.
Liao SC, Cheng YC, Wang YC, Wang CW, Yang SM, Yu CK, Shieh CC, Cheng KC, Lee MF, Chiang SR, Shieh JM, Chang MS
J Immunol. 2004
PubMed ID: 15557163
-
Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein Sci. 2004
PubMed ID: 15340161
-
Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses.
Gallagher G, Eskdale J, Jordan W, Peat J, Campbell J, Boniotto M, Lennon GP, Dickensheets H, Donnelly RP
Int Immunopharmacol. 2004
PubMed ID: 15120647
-
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
-
Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse.
Sugimoto T, Ishikawa Y, Yoshimoto T, Hayashi N, Fujimoto J, Nakanishi K
J Exp Med. 2004
PubMed ID: 14970180
-
Epidermal overexpression of interleukin-19 and -20 mRNA in psoriatic skin disappears after short-term treatment with cyclosporine a or calcipotriol.
Rømer J, Hasselager E, Nørby PL, Steiniche T, Thorn Clausen J, Kragballe K
J Invest Dermatol. 2003
PubMed ID: 14675174
-
Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20.
Pletnev S, Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A, Zdanov A
Biochemistry. 2003
PubMed ID: 14580208
-
Crystal structure of interleukin-19 defines a new subfamily of helical cytokines.
Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A
J Biol Chem. 2003
PubMed ID: 12403790
-
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
-
Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.
Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, Brandt C, Jelinek L, Madden K, McKernan PA, Foster DC, Jaspers S, Chandrasekher YA
J Biol Chem. 2002
PubMed ID: 12351624
-
IL-19 induces production of IL-6 and TNF-alpha and results in cell apoptosis through TNF-alpha.
Liao YC, Liang WG, Chen FW, Hsu JH, Yang JJ, Chang MS
J Immunol. 2002
PubMed ID: 12370360
-
The family of IL-10-related cytokines and their receptors: related, but to what extent?
Kotenko SV
Cytokine Growth Factor Rev. 2002
PubMed ID: 12486876
-
Cutting edge: immune cells as sources and targets of the IL-10 family members?
Wolk K, Kunz S, Asadullah K, Sabat R
J Immunol. 2002
PubMed ID: 12023331
-
The interleukin-10 family of cytokines.
Fickenscher H, Hör S, Küpers H, Knappe A, Wittmann S, Sticht H
Trends Immunol. 2002
PubMed ID: 11929132
-
Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types.
Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC
J Immunol. 2001
PubMed ID: 11564763
-
Interleukin 20: discovery, receptor identification, and role in epidermal function.
Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, Eagan M, Foster D, Haldeman BA, Hammond A, Haugen H, Jelinek L, Kelly JD, Madden K, Maurer MF, Parrish-Novak J, Prunkard D, Sexson S, Sprecher C, Waggie K, West J, Whitmore TE, Yao L, Kuechle MK, Dale BA, Chandrasekher YA
Cell. 2001
PubMed ID: 11163236
-
Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10).
Gallagher G, Dickensheets H, Eskdale J, Izotova LS, Mirochnitchenko OV, Peat JD, Vazquez N, Pestka S, Donnelly RP, Kotenko SV
Genes Immun. 2000
PubMed ID: 11196675
Model Organism Phenotype Links
Top
Help
This section provides links to model organism phenotype resources. Currently only to mouse phenotypes.
External resources (dkCOIN) from NIDDK Consortium Interconnectivity Network
Top
Help
Relevant resources:
Home 
