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ICOS

Gene Description:   inducible T-cell co-stimulator Synonyms:   ICOS, Icos, Ly115, CVID1, CRP-1, CD278, H4, Ailim, MGC39850, CCLP, AILIM Orthologs:   Human ICOS (protein-coding), Mouse Icos (protein-coding), Rat Icos (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, KEGG Human-Rat: KEGG Mouse-Rat: KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

(Human) GRCh37 - chr2:204801471..204826300 (24.83 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr1:61034758..61057164 (22.41 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Symbols represent expression compared with the overall mean. Please click 'HaemAtlasProfile' link below for associated probe mappings and a detailed profile.

CD Marker EB MK CD66b CD14 CD19 CD8 CD4 CD56 Expression Pattern HaemAtlasProfile

Expression Legend CD Marker Cell Type Lineage EB Erythroblast PRECURSOR MK Megakaryocyte PRECURSOR CD66b Granulocyte MYELOID CD14 Monocyte MYELOID CD19 B Lymphocyte LYMPHOID CD8 Tc Lymphocyte LYMPHOID CD4 Th Lymphocyte LYMPHOID CD56 Natural Killer cell LYMPHOID Symbol Expression Level High Moderate Low Not Detected

Interactions Table for ICOS: The ICOS interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs ICOS   ICOSLG   HPRD, BioGRID, Reactome  empirical  11023515  10657606  11956294  15870016  15007255  ICOS   ICOS   HPRD, BioGRID  empirical  11169414

View all

KEGG Network: 4   Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Primary immunodeficiency Human - 5340 Mouse - 5340 Rat - 5340 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660

Biocarta: 1   The Co-Stimulatory Signal During T-cell Activation Human Mouse

Reactome: 1   Costimulation by the CD28 family REACT_19344

NCI-Nature Pathway Interaction Database: None available   None available.

Gene Ontology: 7   Extracellular region GO:0005576 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 External side of plasma membrane GO:0009897 Integral to membrane GO:0016021 T cell costimulation GO:0031295

	KEGG Network: 4 Cell adhesion molecules (CAMs) Human - 4514 Mouse - 4514 Rat - 4514 Intestinal immune network for IgA production Human - 4672 Mouse - 4672 Rat - 4672 Primary immunodeficiency Human - 5340 Mouse - 5340 Rat - 5340 T cell receptor signaling pathway Human - 4660 Mouse - 4660 Rat - 4660
	Biocarta: 1 The Co-Stimulatory Signal During T-cell Activation Human Mouse
	Reactome: 1 Costimulation by the CD28 family REACT_19344
	NCI-Nature Pathway Interaction Database: None available
	Gene Ontology: 7 Extracellular region GO:0005576 Plasma membrane GO:0005886 Integral to plasma membrane GO:0005887 Immune response GO:0006955 External side of plasma membrane GO:0009897 Integral to membrane GO:0016021 T cell costimulation GO:0031295

Type 1 Diabetes Publications: 11

• Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system.
  Prevot N, Briet C, Lassmann H, Tardivel I, Roy E, Morin J, Mak TW, Tafuri A, Boitard C
  Eur J Immunol. 2010
  PubMed ID: 20544729
   
  
• Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?
  Bouwhuis MG, Gast A, Figl A, Eggermont AM, Hemminki K, Schadendorf D, Kumar R
  Cancer Immunol Immunother. 2009
  PubMed ID: 19672595
   
  
• Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates.
  Douroudis K, Laine AP, Heinonen M, Hermann R, Lipponen K, Veijola R, Simell O, Knip M, Uibo R, Ilonen J, Kisand K
  Hum Immunol. 2009
  PubMed ID: 19376178
   
  
• Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes.
  Luczyński W, Wawrusiewicz-Kurylonek N, Stasiak-Barmuta A, Urban R, Iłendo E, Urban M, Hryszko M, Kretowski A, Górska M
  Acta Biochim Pol. 2009
  PubMed ID: 19547759
   
  
• Poor in vitro induction of FOXP3 and ICOS in type 1 cytokine environment activated T-cells from children with type 1 diabetes.
  Honkanen J, Skarsvik S, Knip M, Vaarala O
  Diabetes Metab Res Rev. 2008
  PubMed ID: 18973208
   
  
• ICOS mediates the development of insulin-dependent diabetes mellitus in nonobese diabetic mice.
  Hawiger D, Tran E, Du W, Booth CJ, Wen L, Dong C, Flavell RA
  J Immunol. 2008
  PubMed ID: 18292537
   
  
• Role of ICOS pathway in autoimmune and alloimmune responses in NOD mice.
  Ansari MJ, Fiorina P, Dada S, Guleria I, Ueno T, Yuan X, Trikudanathan S, Smith RN, Freeman G, Sayegh MH
  Clin Immunol. 2008
  PubMed ID: 17889619
   
  
• Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.
  Nanji SA, Hancock WW, Luo B, Schur CD, Pawlick RL, Zhu LF, Anderson CC, Shapiro AM
  Diabetes. 2006
  PubMed ID: 16380473
   
  
• Acceptance of islet allografts in the liver of mice by blockade of an inducible costimulator.
  Nakamura Y, Yasunami Y, Satoh M, Hirakawa E, Katsuta H, Ono J, Kamada M, Todo S, Nakayama T, Taniguchi M, Ikeda S
  Transplantation. 2003
  PubMed ID: 12717187
   
  
• Further mapping of the Idd5.1 locus for autoimmune diabetes in NOD mice.
  Lamhamedi-Cherradi SE, Boulard O, Gonzalez C, Kassis N, Damotte D, Eloy L, Fluteau G, Lévi-Strauss M, Garchon HJ
  Diabetes. 2001
  PubMed ID: 11723074
   
  
• CTLA-4-/- mice display T cell-apoptosis resistance resembling that ascribed to autoimmune-prone non-obese diabetic (NOD) mice.
  Bergman ML, Cilio CM, Penha-Gonçalves C, Lamhamedi-Cherradi SE, Löfgren A, Colucci F, Lejon K, Garchon HJ, Holmberg D
  J Autoimmun. 2001
  PubMed ID: 11247636
   
  

Publications: 204

• ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.
  Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C, Crotty S
  Immunity. 2011
  PubMed ID: 21636296
   
  
• Prolonged xenograft survival induced by inducible costimulator-Ig is associated with increased forkhead box P3(+) cells.
  Hodgson R, Christiansen D, Ziolkowski A, Mouhtouris E, Simeonovic CJ, Ierino FL, Sandrin MS
  Transplantation. 2011
  PubMed ID: 21544030
   
  
• Association of CTLA4, CD28 and ICOS gene polymorphisms with clinicopathologic characteristics of childhood IgA nephropathy in Korean population.
  Kim HJ, Chung JH, Kang S, Kim SK, Cho BS, Kim SD, Hahn WH
  J Genet. 2011
  PubMed ID: 21677403
   
  
• Impact of inducible co-stimulatory molecule (ICOS) on T-cell responses and protection against Mycobacterium tuberculosis infection.
  Nouailles G, Day TA, Kuhlmann S, Loewe D, Dorhoi A, Gamradt P, Hurwitz R, Jörg S, Pradl L, Hutloff A, Koch M, Kursar M, Kaufmann SH
  Eur J Immunol. 2011
  PubMed ID: 21337542
   
  
• Immunoregulatory gene polymorphisms in women with preeclampsia.
  Pendeloski KP, Sass N, Torloni MR, Mattar R, Moron AF, Franchim CS, Daher S
  Hypertens Res. 2011
  PubMed ID: 21160481
   
  
• Protective effector memory CD4 T cells depend on ICOS for survival.
  Moore TV, Clay BS, Ferreira CM, Williams JW, Rogozinska M, Cannon JL, Shilling RA, Marzo AL, Sperling AI
  PLoS One. 2011
  PubMed ID: 21364749
   
  
• Differences in allergen-induced T cell activation between allergic asthma and rhinitis: Role of CD28, ICOS and CTLA-4.
  Botturi K, Lacoeuille Y, Cavaillès A, Vervloet D, Magnan A
  Respir Res. 2011
  PubMed ID: 21356099
   
  
• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
  PLoS Biol. 2011
  PubMed ID: 21267068
   
  
• ICOS gene polymorphism may be associated with pemphigus.
  Narbutt J, Lesiak A, Klich I, Torzecka JD, Sysa-Jedrzejowska A, Młynarski W
  J Cutan Med Surg. 2010
  PubMed ID: 21084022
   
  
• The inducible costimulator (ICOS) is critical for the development of human T(H)17 cells.
  Paulos CM, Carpenito C, Plesa G, Suhoski MM, Varela-Rohena A, Golovina TN, Carroll RG, Riley JL, June CH
  Sci Transl Med. 2010
  PubMed ID: 20980695
   
  
• B7h triggering inhibits umbilical vascular endothelial cell adhesiveness to tumor cell lines and polymorphonuclear cells.
  Dianzani C, Minelli R, Mesturini R, Chiocchetti A, Barrera G, Boscolo S, Sarasso C, Gigliotti CL, Sblattero D, Yagi J, Rojo JM, Fantozzi R, Dianzani U
  J Immunol. 2010
  PubMed ID: 20817864
   
  
• Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.
  Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R, Tangye SG
  Immunity. 2010
  PubMed ID: 20691615
   
  
• Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells.
  Vocanson M, Rozieres A, Hennino A, Poyet G, Gaillard V, Renaudineau S, Achachi A, Benetiere J, Kaiserlian D, Dubois B, Nicolas JF
  J Allergy Clin Immunol. 2010
  PubMed ID: 20624644
   
  
• Genome-wide association study in alopecia areata implicates both innate and adaptive immunity.
  Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM
  Nature. 2010
  PubMed ID: 20596022
   
  
• A Large-scale genetic association study of esophageal adenocarcinoma risk.
  Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
  Carcinogenesis. 2010
  PubMed ID: 20453000
   
  
• Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma.
  Kämmerer PW, Toyoshima T, Schöder F, Kämmerer P, Kuhr K, Brieger J, Al-Nawas B
  Oral Oncol. 2010
  PubMed ID: 20435510
   
  
• ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice.
  Hondowicz BD, Batheja AO, Metzgar MH, Caton AJ, Erikson J
  J Autoimmun. 2010
  PubMed ID: 20022728
   
  
• Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.
  Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL
  J Infect Dis. 2010
  PubMed ID: 20331378
   
  
• New genetic associations detected in a host response study to hepatitis B vaccine.
  Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
  Genes Immun. 2010
  PubMed ID: 20237496
   
  
• Multiple common variants for celiac disease influencing immune gene expression.
  Dubois PC, Trynka G, Franke L, Hunt KA, Romanos J, Curtotti A, Zhernakova A, Heap GA, Adány R, Aromaa A, Bardella MT, van den Berg LH, Bockett NA, de la Concha EG, Dema B, Fehrmann RS, Fernández-Arquero M, Fiatal S, Grandone E, Green PM, Groen HJ, Gwilliam R, Houwen RH, Hunt SE, Kaukinen K, Kelleher D, Korponay-Szabo I, Kurppa K, MacMathuna P, Mäki M, Mazzilli MC, McCann OT, Mearin ML, Mein CA, Mirza MM, Mistry V, Mora B, Morley KI, Mulder CJ, Murray JA, Núñez C, Oosterom E, Ophoff RA, Polanco I, Peltonen L, Platteel M, Rybak A, Salomaa V, Schweizer JJ, Sperandeo MP, Tack GJ, Turner G, Veldink JH, Verbeek WH, Weersma RK, Wolters VM, Urcelay E, Cukrowska B, Greco L, Neuhausen SL, McManus R, Barisani D, Deloukas P, Barrett JC, Saavalainen P, Wijmenga C, van Heel DA
  Nat Genet. 2010
  PubMed ID: 20190752
   
  
• The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation.
  Marafioti T, Paterson JC, Ballabio E, Chott A, Natkunam Y, Rodriguez-Justo M, Plonquet A, Rodriguez-Pinilla SM, Klapper W, Hansmann ML, Pileri SA, Isaacson PG, Stein H, Piris MA, Mason DY, Gaulard P
  Haematologica. 2010
  PubMed ID: 20207847
   
  
• Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis.
  Kim YO, Kim HJ, Kim SK, Chung JH, Hong SJ
  Clin Chem Lab Med. 2010
  PubMed ID: 20113255
   
  
• Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.
  Ivansson EL, Juko-Pecirep I, Gyllensten UB
  Gynecol Oncol. 2010
  PubMed ID: 19959217
   
  
• Flt3-L increases CD4+CD25+Foxp3+ICOS+ cells in the lungs of cockroach-sensitized and -challenged mice.
  McGee HS, Edwan JH, Agrawal DK
  Am J Respir Cell Mol Biol. 2010
  PubMed ID: 19448155
   
  
• Influence of CTLA-4/CD28/ICOS gene polymorphisms on the susceptibility to cervical squamous cell carcinoma and stage of differentiation in the Polish population.
  Pawlak E, Karabon L, Wlodarska-Polinska I, Jedynak A, Jonkisz A, Tomkiewicz A, Kornafel J, Stepien M, Ignatowicz A, Lebioda A, Dobosz T, Frydecka I
  Hum Immunol. 2010
  PubMed ID: 19913589
   
  
• ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice.
  Schaefer JS, Montufar-Solis D, Vigneswaran N, Klein JR
  J Leukoc Biol. 2010
  PubMed ID: 19889730
   
  
• Suppression of Con A-induced hepatitis induction in ICOS-deficient mice.
  Watanabe S, Ohnuki K, Hara Y, Ishida Y, Ikarashi Y, Ogawa S, Kishimoto H, Tanabe K, Abe R
  Immunol Lett. 2010
  PubMed ID: 19914290
   
  
• [Expression of co-stimulators in ulcerative colitis and its pathologic significance].
  Li F, Chen AJ, Du J, Zhang Y, Gong EC, Shi XY
  Zhonghua Bing Li Xue Za Zhi. 2010
  PubMed ID: 20388394
   
  
• Definitive evidence that a single N-glycan among three glycans on inducible costimulator is required for proper protein trafficking and ligand binding.
  Kamei N, Fukui R, Suzuki Y, Kajihara Y, Kinoshita M, Kakehi K, Hojo H, Tezuka K, Tsuji T
  Biochem Biophys Res Commun. 2010
  PubMed ID: 19931508
   
  
• [Expression of co-stimulatory molecule CD86 and its inducible co-stimulator in Crohn disease and their pathologic significance].
  Chen AJ, Li F, DU J, Zhang Y, Gong EC, Shi XY
  Beijing Da Xue Xue Bao. 2009
  PubMed ID: 20019769
   
  
• Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase.
  Gigoux M, Shang J, Pak Y, Xu M, Choe J, Mak TW, Suh WK
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19915142
   
  
• Association and interaction analyses of eight genes under asthma linkage peaks.
  Ferreira MA, Zhao ZZ, Thomsen SF, James M, Evans DM, Postmus PE, Kyvik KO, Backer V, Boomsma DI, Martin NG, Montgomery GW, Duffy DL
  Allergy. 2009
  PubMed ID: 19824886
   
  
• Reverse signaling using an inducible costimulator to enhance immunogenic function of dendritic cells.
  Tang G, Qin Q, Zhang P, Wang G, Liu M, Ding Q, Qin Y, Shen Q
  Cell Mol Life Sci. 2009
  PubMed ID: 19603141
   
  
• Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
  Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK
  J Immunol. 2009
  PubMed ID: 19570826
   
  
• ICOS deficiency results in exacerbated IL-17 mediated experimental autoimmune encephalomyelitis.
  Galicia G, Kasran A, Uyttenhove C, De Swert K, Van Snick J, Ceuppens JL
  J Clin Immunol. 2009
  PubMed ID: 19291374
   
  
• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
  PLoS Biol. 2009
  PubMed ID: 19468303
   
  
• Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients.
  Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, Azuma M, Lee SK, Mizutani S, Morio T
  J Immunol. 2009
  PubMed ID: 19380800
   
  
• Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation.
  Wu J, Tang JL, Wu SJ, Lio HY, Yang YC
  Clin Chim Acta. 2009
  PubMed ID: 19332044
   
  
• Analyses of associations with asthma in four asthma population samples from Canada and Australia.
  Daley D, Lemire M, Akhabir L, Chan-Yeung M, He JQ, McDonald T, Sandford A, Stefanowicz D, Tripp B, Zamar D, Bosse Y, Ferretti V, Montpetit A, Tessier MC, Becker A, Kozyrskyj AL, Beilby J, McCaskie PA, Musk B, Warrington N, James A, Laprise C, Palmer LJ, Paré PD, Hudson TJ
  Hum Genet. 2009
  PubMed ID: 19247692
   
  
• CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population.
  Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Lu Y, Coltescu C, Wang K, Newman WG, Bykerk V, Keystone EC, Mosher D, Amos CI, Heathcote EJ, Siminovitch KA
  Arthritis Rheum. 2009
  PubMed ID: 19333938
   
  
• ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.
  Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J
  J Immunol. 2009
  PubMed ID: 19299705
   
  
• The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells.
  Tuettenberg A, Huter E, Hubo M, Horn J, Knop J, Grimbacher B, Kroczek RA, Stoll S, Jonuleit H
  J Immunol. 2009
  PubMed ID: 19265111
   
  
• Inducible costimulator (ICOS) enhances the cytolytic activity of cytokine-induced killer cells against gallbladder cancer in vitro and in vivo.
  Wang J, He M, Shi W, Sha H, Feng J, Wang S, Wang Y
  Cancer Invest. 2009
  PubMed ID: 19194830
   
  
• Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner.
  Franko JL, Levine AD
  J Leukoc Biol. 2009
  PubMed ID: 19095735
   
  
• The shared CTLA4-ICOS risk locus in celiac disease, IgA deficiency and common variable immunodeficiency.
  Haimila K, Einarsdottir E, de Kauwe A, Koskinen LL, Pan-Hammarström Q, Kaartinen T, Kurppa K, Ziberna F, Not T, Vatta S, Ventura A, Korponay-Szabo IR, Adány R, Pocsai Z, Széles G, Dukes E, Kaukinen K, Mäki M, Koskinen S, Partanen J, Hammarström L, Saavalainen P
  Genes Immun. 2009
  PubMed ID: 19020530
   
  
• Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
  Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG
  Immunity. 2009
  PubMed ID: 19217324
   
  
• Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation.
  Haimila K, Turpeinen H, Alakulppi NS, Kyllönen LE, Salmela KT, Partanen J
  Transplantation. 2009
  PubMed ID: 19202444
   
  
• A haplotype in the inducible T-cell tyrosine kinase is a risk factor for seasonal allergic rhinitis.
  Benson M, Mobini R, Barrenäs F, Halldén C, Naluai AT, Säll T, Cardell LO
  Allergy. 2009
  PubMed ID: 19222422
   
  
• The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells.
  Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK
  Nat Immunol. 2009
  PubMed ID: 19098919
   
  
• Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol.
  Lu H, Kaplan BL, Ngaotepprutaram T, Kaminski NE
  J Leukoc Biol. 2009
  PubMed ID: 18988696
   
  
• Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells.
  Clay BS, Shilling RA, Bandukwala HS, Moore TV, Cannon JL, Welcher AA, Weinstock JV, Sperling AI
  PLoS One. 2009
  PubMed ID: 19888475
   
  
• CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
  Shilling RA, Clay BS, Tesciuba AG, Berry EL, Lu T, Moore TV, Bandukwala HS, Tong J, Weinstock JV, Flavell RA, Horan T, Yoshinaga SK, Welcher AA, Cannon JL, Sperling AI
  Cell Immunol. 2009
  PubMed ID: 19646680
   
  
• Defects of mitogen-activated protein kinase in ICOS signaling pathway lead to CD4(+) and CD8(+) T-cell dysfunction in patients with active SLE.
  Gang C, Jiahui Y, Huaizhou W, Qing C, Dongbao Z, Qian S
  Cell Immunol. 2009
  PubMed ID: 19376499
   
  
• Functional hierarchy and relative contribution of the CD28/B7 and ICOS/B7-H2 costimulatory pathways to T cell-mediated delayed-type hypersensitivity.
  Wong SC, Tan AH, Lam KP
  Cell Immunol. 2009
  PubMed ID: 19249753
   
  
• Effector functions of donor-reactive CD8 memory T cells are dependent on ICOS induced during division in cardiac grafts.
  Schenk AD, Gorbacheva V, Rabant M, Fairchild RL, Valujskikh A
  Am J Transplant. 2009
  PubMed ID: 18976292
   
  
• A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.
  Chen Q, Cannons JL, Paton JC, Akiba H, Schwartzberg PL, Snapper CM
  J Immunol. 2008
  PubMed ID: 19050242
   
  
• Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus.
  Abe J, Ueha S, Suzuki J, Tokano Y, Matsushima K, Ishikawa S
  Am J Pathol. 2008
  PubMed ID: 19008373
   
  
• ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.
  Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J
  J Exp Med. 2008
  PubMed ID: 18981236
   
  
• ICOS-gene variants are not associated with atopic disease susceptibility in European children.
  Beier KC, Humberdros S, Witt H, Illi S, Rüschendorf F, Nickel R, Lee YA, Lau S, Wahn U, Hamelmann E
  Pediatr Allergy Immunol. 2008
  PubMed ID: 19175887
   
  
• CD28 controls differentiation of regulatory T cells from naive CD4 T cells.
  Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ
  J Immunol. 2008
  PubMed ID: 18684917
   
  
• ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse.
  Fos C, Salles A, Lang V, Carrette F, Audebert S, Pastor S, Ghiotto M, Olive D, Bismuth G, Nunès JA
  J Immunol. 2008
  PubMed ID: 18641334
   
  
• ICOS costimulation expands Th2 immunity by augmenting migration of lymphocytes to draining lymph nodes.
  Tesciuba AG, Shilling RA, Agarwal MD, Bandukwala HS, Clay BS, Moore TV, Weinstock JV, Welcher AA, Sperling AI
  J Immunol. 2008
  PubMed ID: 18606653
   
  
• New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer.
  Guzman VB, Yambartsev A, Goncalves-Primo A, Silva ID, Carvalho CR, Ribalta JC, Goulart LR, Shulzhenko N, Gerbase-Delima M, Morgun A
  Hum Mol Genet. 2008
  PubMed ID: 18337305
   
  
• ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival.
  Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH
  J Immunol. 2008
  PubMed ID: 18390727
   
  
• Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses.
  Watanabe M, Takagi Y, Kotani M, Hara Y, Inamine A, Hayashi K, Ogawa S, Takeda K, Tanabe K, Abe R
  J Immunol. 2008
  PubMed ID: 18390703
   
  
• CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'.
  Rojo JM, Pini E, Ojeda G, Bello R, Dong C, Flavell RA, Dianzani U, Portolés P
  Int Immunol. 2008
  PubMed ID: 18310064
   
  
• Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population.
  Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak-Kujda D, Kuliczkowski K, Wolowiec D, Jedynak A, Frydecka I
  Hum Immunol. 2008
  PubMed ID: 18396212
   
  
• Expression of ICOS on human melanoma-infiltrating CD4+CD25highFoxp3+ T regulatory cells: implications and impact on tumor-mediated immune suppression.
  Strauss L, Bergmann C, Szczepanski MJ, Lang S, Kirkwood JM, Whiteside TL
  J Immunol. 2008
  PubMed ID: 18292519
   
  
• ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction.
  Vu F, Dianzani U, Ware CF, Mak T, Gommerman JL
  J Immunol. 2008
  PubMed ID: 18250437
   
  
• A critical role of costimulation during intrathymic development of invariant NK T cells.
  Chung Y, Nurieva R, Esashi E, Wang YH, Zhou D, Gapin L, Dong C
  J Immunol. 2008
  PubMed ID: 18250436
   
  
• Association of polymorphisms in complement component C3 gene with susceptibility to systemic lupus erythematosus.
  Miyagawa H, Yamai M, Sakaguchi D, Kiyohara C, Tsukamoto H, Kimoto Y, Nakamura T, Lee JH, Tsai CY, Chiang BL, Shimoda T, Harada M, Tahira T, Hayashi K, Horiuchi T
  Rheumatology (Oxford). 2008
  PubMed ID: 18174230
   
  
• ICOS controls the pool size of effector-memory and regulatory T cells.
  Burmeister Y, Lischke T, Dahler AC, Mages HW, Lam KP, Coyle AJ, Kroczek RA, Hutloff A
  J Immunol. 2008
  PubMed ID: 18178815
   
  
• T helper cell-specific regulation of inducible costimulator expression via distinct mechanisms mediated by T-bet and GATA-3.
  Tan AH, Goh SY, Wong SC, Lam KP
  J Biol Chem. 2008
  PubMed ID: 17986443
   
  
• Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.
  Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG
  Nature. 2007
  PubMed ID: 18172933
   
  
• Analysis of genetic defects in patients with the common variable immunodeficiency phenotype in a single Taiwanese tertiary care hospital.
  Lee WI, Huang JL, Kuo ML, Lin SJ, Chen LC, Chen MT, Jaing TH
  Ann Allergy Asthma Immunol. 2007
  PubMed ID: 18051214
   
  
• Differential CD28 and inducible costimulatory molecule signaling requirements for protective CD4+ T-cell-mediated immunity against genital tract Chlamydia trachomatis infection.
  Marks E, Verolin M, Stensson A, Lycke N
  Infect Immun. 2007
  PubMed ID: 17635872
   
  
• The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells.
  Mahajan S, Cervera A, MacLeod M, Fillatreau S, Perona-Wright G, Meek S, Smith A, MacDonald A, Gray D
  Eur J Immunol. 2007
  PubMed ID: 17549732
   
  
• ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution.
  Castelli L, Comi C, Chiocchetti A, Nicola S, Mesturini R, Giordano M, D'Alfonso S, Cerutti E, Galimberti D, Fenoglio C, Tesser F, Yagi J, Rojo JM, Perla F, Leone M, Scarpini E, Monaco F, Dianzani U
  J Neuroimmunol. 2007
  PubMed ID: 17481737
   
  
• ICOS and B7 costimulatory molecule expression identifies activated cellular subsets in rheumatoid arthritis.
  Ruth JH, Rottman JB, Kingsbury GA, Coyle AJ, Haines GK, Pope RM, Koch AE
  Cytometry A. 2007
  PubMed ID: 17323353
   
  
• Diagnosis of acute renal allograft rejection by analyzing whole blood mRNA expression of lymphocyte marker molecules.
  Alakulppi NS, Kyllönen LE, Partanen J, Salmela KT, Laine JT
  Transplantation. 2007
  PubMed ID: 17414714
   
  
• hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
  Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
  Genomics. 2007
  PubMed ID: 17207965
   
  
• Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4.
  Kaartinen T, Lappalainen J, Haimila K, Autero M, Partanen J
  Mol Immunol. 2007
  PubMed ID: 16996590
   
  
• Expression of CD28-related costimulatory molecule and its ligand in inflammatory neuropathies.
  Hu W, Janke A, Ortler S, Hartung HP, Leder C, Kieseier BC, Wiendl H
  Neurology. 2007
  PubMed ID: 17242332
   
  
• Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes.
  Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17197413
   
  
• Gut IgA class switch recombination in the absence of CD40 does not occur in the lamina propria and is independent of germinal centers.
  Bergqvist P, Gärdby E, Stensson A, Bemark M, Lycke NY
  J Immunol. 2006
  PubMed ID: 17114448
   
  
• AILIM/ICOS-mediated elongation of activated T cells is regulated by both the PI3-kinase/Akt and Rho family cascade.
  Nukada Y, Okamoto N, Konakahara S, Tezuka K, Ohashi K, Mizuno K, Tsuji T
  Int Immunol. 2006
  PubMed ID: 17077177
   
  
• A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors.
  Zang X, Loke P, Kim J, Wojnoonski K, Kusdra L, Allison JP
  Genomics. 2006
  PubMed ID: 17014982
   
  
• Critical role of inducible costimulator signaling in the development of arteriosclerosis.
  Kosuge H, Suzuki J, Haraguchi G, Koga N, Maejima Y, Inobe M, Isobe M, Uede T
  Arterioscler Thromb Vasc Biol. 2006
  PubMed ID: 16990558
   
  
• Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis.
  Xing L, Yang P, Wu C, Jin H, Chen X, Gao Y, Li B, Huang X, Zhou H
  Graefes Arch Clin Exp Ophthalmol. 2006
  PubMed ID: 16601981
   
  
• Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.
  Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH
  Circulation. 2006
  PubMed ID: 17060381
   
  
• A critical role for ICOS co-stimulation in immune containment of pulmonary influenza virus infection.
  Humphreys IR, Edwards L, Snelgrove RJ, Rae AJ, Coyle AJ, Hussell T
  Eur J Immunol. 2006
  PubMed ID: 17039567
   
  
• The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.
  Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, Okunuki Y, Yamazaki T, Yagita H, Usui M, Okumura K
  Eur J Immunol. 2006
  PubMed ID: 17039566
   
  
• ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells.
  Bossaller L, Burger J, Draeger R, Grimbacher B, Knoth R, Plebani A, Durandy A, Baumann U, Schlesier M, Welcher AA, Peter HH, Warnatz K
  J Immunol. 2006
  PubMed ID: 16982935
   
  
• Regulation of T:B cell interactions by the inducible costimulator molecule: does ICOS "induce" disease?
  Shilling RA, Bandukwala HS, Sperling AI
  Clin Immunol. 2006
  PubMed ID: 16790364
   
  
• Regulation of mouse inducible costimulator (ICOS) expression by Fyn-NFATc2 and ERK signaling in T cells.
  Tan AH, Wong SC, Lam KP
  J Biol Chem. 2006
  PubMed ID: 16880206
   
  
• B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses.
  Wilson EH, Zaph C, Mohrs M, Welcher A, Siu J, Artis D, Hunter CA
  J Immunol. 2006
  PubMed ID: 16887998
   
  
• Role of inducible costimulator in the development of lupus in MRL/lpr mice.
  Tada Y, Koarada S, Tomiyoshi Y, Morito F, Mitamura M, Haruta Y, Ohta A, Nagasawa K
  Clin Immunol. 2006
  PubMed ID: 16616645
   
  
• Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells.
  Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C
  J Immunol. 2006
  PubMed ID: 16751384
   
  
• T-cell tolerance or function is determined by combinatorial costimulatory signals.
  Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C
  EMBO J. 2006
  PubMed ID: 16724117
   
  
• High resolution mapping of chromosomal regions controlling resistance to gastrointestinal nematode infections in an advanced intercross line of mice.
  Behnke JM, Iraqi FA, Mugambi JM, Clifford S, Nagda S, Wakelin D, Kemp SJ, Baker RL, Gibson JP
  Mamm Genome. 2006
  PubMed ID: 16783640
   
  
• Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis.
  Quiroga MF, Pasquinelli V, Martínez GJ, Jurado JO, Zorrilla LC, Musella RM, Abbate E, Sieling PA, García VE
  J Immunol. 2006
  PubMed ID: 16670305
   
  
• No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis.
  Wiencke K, Boberg KM, Donaldson P, Harbo H, Ling V, Schrumpf E, Spurkland A
  Scand J Gastroenterol. 2006
  PubMed ID: 16638702
   
  
• Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection.
  Montufar-Solis D, Garza T, Teng BB, Klein JR
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16500623
   
  
• Expression level of costimulatory receptor ICOS is critical for determining the polarization of helper T cell function.
  Watanabe S, Ogawa S, Hara Y, Tanabe K, Toma H, Abe R
  Transpl Immunol. 2006
  PubMed ID: 16635747
   
  
• No association between selected candidate gene polymorphisms and severe chronic periodontitis.
  Wohlfahrt JC, Wu T, Hodges JS, Hinrichs JE, Michalowicz BS
  J Periodontol. 2006
  PubMed ID: 16512757
   
  
• Role for inducible costimulator in control of Salmonella enterica serovar Typhimurium infection in mice.
  Vidric M, Bladt AT, Dianzani U, Watts TH
  Infect Immun. 2006
  PubMed ID: 16428752
   
  
• Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production.
  Kawamoto M, Harigai M, Hara M, Kawaguchi Y, Tezuka K, Tanaka M, Sugiura T, Katsumata Y, Fukasawa C, Ichida H, Higami S, Kamatani N
  Arthritis Res Ther. 2006
  PubMed ID: 16563187
   
  
• Haplotypes in the CTLA4 region are associated with coeliac disease in the Irish population.
  Brophy K, Ryan AW, Thornton JM, Abuzakouk M, Fitzgerald AP, McLoughlin RM, O'morain C, Kennedy NP, Stevens FM, Feighery C, Kelleher D, McManus R
  Genes Immun. 2006
  PubMed ID: 16237465
   
  
• The ICOS molecule plays a crucial role in the development of mucosal tolerance.
  Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH
  J Immunol. 2005
  PubMed ID: 16301640
   
  
• Cooperation between 4-1BB and ICOS in the immune response to influenza virus revealed by studies of CD28/ICOS-deficient mice.
  Vidric M, Suh WK, Dianzani U, Mak TW, Watts TH
  J Immunol. 2005
  PubMed ID: 16301634
   
  
• A function for interleukin 2 in Foxp3-expressing regulatory T cells.
  Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY
  Nat Immunol. 2005
  PubMed ID: 16227984
   
  
• A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.
  Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, Dong C
  Nat Immunol. 2005
  PubMed ID: 16200068
   
  
• Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation.
  Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Muriglan SJ, Kochman AA, Terwey TH, Willis LM, Schiro R, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR
  Blood. 2005
  PubMed ID: 15956289
   
  
• A functional role for inducible costimulator (ICOS) in atherosclerosis.
  Afek A, Harats D, Roth A, Keren G, George J
  Atherosclerosis. 2005
  PubMed ID: 15941568
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Analysis of inducible costimulatory molecule participation during the induction and elicitation of granulomatous responses to mycobacterial and schistosomal antigens.
  Stolberg VR, Chiu BC, Komuniecki E, Freeman CM, Chensue SW
  Cell Immunol. 2005
  PubMed ID: 16300749
   
  
• Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients.
  Lorentzen AR, Celius EG, Ekstrøm PO, Wiencke K, Lie BA, Myhr KM, Ling V, Thorsby E, Vartdal F, Spurkland A, Harbo HF
  J Neuroimmunol. 2005
  PubMed ID: 16005527
   
  
• Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade.
  Guillonneau C, Aubry V, Renaudin K, Séveno C, Usal C, Tezuka K, Anegon I
  Transplantation. 2005
  PubMed ID: 16220623
   
  
• The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.
  Akiba H, Takeda K, Kojima Y, Usui Y, Harada N, Yamazaki T, Ma J, Tezuka K, Yagita H, Okumura K
  J Immunol. 2005
  PubMed ID: 16081804
   
  
• Cutting edge: polymorphisms in the ICOS promoter region are associated with allergic sensitization and Th2 cytokine production.
  Shilling RA, Pinto JM, Decker DC, Schneider DH, Bandukwala HS, Schneider JR, Camoretti-Mercado B, Ober C, Sperling AI
  J Immunol. 2005
  PubMed ID: 16081771
   
  
• Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease.
  Mazón Peláez I, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
  Hum Mol Genet. 2005
  PubMed ID: 15917267
   
  
• Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection.
  Loke P, Zang X, Hsuan L, Waitz R, Locksley RM, Allen JE, Allison JP
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 15994233
   
  
• Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups.
  Guzman VB, Morgun A, Shulzhenko N, Mine KL, Gonçalves-Primo A, Musatti CC, Gerbase-Delima M
  Hum Immunol. 2005
  PubMed ID: 16112024
   
  
• ICOS contributes to T cell expansion in CTLA-4 deficient mice.
  van Berkel ME, Schrijver EH, Hofhuis FM, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA
  J Immunol. 2005
  PubMed ID: 15972646
   
  
• Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma.
  Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, Bianchi A, Calvisi A, Curreli L, Gaviano E, Lai P, Murgia A, Latte GC, Noli A, Gabbas A
  Br J Haematol. 2005
  PubMed ID: 15953005
   
  
• Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection.
  Kashizuka H, Sho M, Nomi T, Ikeda N, Kuzumoto Y, Akashi S, Tsurui Y, Mizuno T, Kanehiro H, Yagita H, Nakajima Y, Sayegh MH
  Transplantation. 2005
  PubMed ID: 15880041
   
  
• A common CTLA4 haplotype associated with coeliac disease.
  Hunt KA, McGovern DP, Kumar PJ, Ghosh S, Travis SP, Walters JR, Jewell DP, Playford RJ, van Heel DA
  Eur J Hum Genet. 2005
  PubMed ID: 15657618
   
  
• B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance.
  Gajewska BU, Tafuri A, Swirski FK, Walker T, Johnson JR, Shea T, Shahinian A, Goncharova S, Mak TW, Stämpfli MR, Jordana M
  J Immunol. 2005
  PubMed ID: 15728513
   
  
• ICOS-mediated costimulation on Th2 differentiation is achieved by the enhancement of IL-4 receptor-mediated signaling.
  Watanabe M, Watanabe S, Hara Y, Harada Y, Kubo M, Tanabe K, Toma H, Abe R
  J Immunol. 2005
  PubMed ID: 15699127
   
  
• Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism.
  Gondek DC, Lu LF, Quezada SA, Sakaguchi S, Noelle RJ
  J Immunol. 2005
  PubMed ID: 15699103
   
  
• ICOS costimulates invariant NKT cell activation.
  Kaneda H, Takeda K, Ota T, Kaduka Y, Akiba H, Ikarashi Y, Wakasugi H, Kronenberg M, Kinoshita K, Yagita H, Okumura K
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15629449
   
  
• ICOS deficiency in patients with common variable immunodeficiency.
  Salzer U, Maul-Pavicic A, Cunningham-Rundles C, Urschel S, Belohradsky BH, Litzman J, Holm A, Franco JL, Plebani A, Hammarstrom L, Skrabl A, Schwinger W, Grimbacher B
  Clin Immunol. 2004
  PubMed ID: 15507387
   
  
• Effects of double blockade of CD28 and inducible-costimulator signaling on anti-glomerular basement membrane glomerulonephritis.
  Okano K, Nitta K, Ogawa S, Horita S, Habiro K, Nihei H, Abe R
  J Lab Clin Med. 2004
  PubMed ID: 15514586
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis.
  Scales HE, Ierna MX, Gutierrez-Ramos JC, Coyle AJ, Garside P, Lawrence CE
  Eur J Immunol. 2004
  PubMed ID: 15368302
   
  
• AILIM/ICOS signaling induces T-cell migration/polarization of memory/effector T-cells.
  Okamoto N, Nukada Y, Tezuka K, Ohashi K, Mizuno K, Tsuji T
  Int Immunol. 2004
  PubMed ID: 15339883
   
  
• ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells.
  Wassink L, Vieira PL, Smits HH, Kingsbury GA, Coyle AJ, Kapsenberg ML, Wierenga EA
  J Immunol. 2004
  PubMed ID: 15265908
   
  
• The inducible costimulator plays the major costimulatory role in humoral immune responses in the absence of CD28.
  Suh WK, Tafuri A, Berg-Brown NN, Shahinian A, Plyte S, Duncan GS, Okada H, Wakeham A, Odermatt B, Ohashi PS, Mak TW
  J Immunol. 2004
  PubMed ID: 15128772
   
  
• Human T cell activation by costimulatory signal-deficient allogeneic cells induces inducible costimulator-expressing anergic T cells with regulatory cell activity.
  Vermeiren J, Ceuppens JL, Van Ghelue M, Witters P, Bullens D, Mages HW, Kroczek RA, Van Gool SW
  J Immunol. 2004
  PubMed ID: 15100277
   
  
• The inhibitory effects of mouse ICOS-Ig gene-modified mouse dendritic cells on T cells.
  Wang G, Zhu L, Hu P, Zhu H, Lei P, Liao W, Yu B, Gong F, Shen G
  Cell Mol Immunol. 2004
  PubMed ID: 16212904
   
  
• Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.
  Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T
  Gastroenterology. 2004
  PubMed ID: 14988837
   
  
• Hyperexpression of inducible costimulator on lamina propria mononuclear cells in rat dextran sulfate sodium colitis.
  Ishii K, Kanai T, Totsuka T, Uraushihara K, Ishikura T, Yamazaki M, Okamoto R, Araki A, Miyata T, Tezuka K, Nakamura T, Watanabe M
  J Gastroenterol Hepatol. 2004
  PubMed ID: 14731127
   
  
• Differential regulation of peripheral CD4+ T cell tolerance induced by deletion and TCR revision.
  Ali M, Weinreich M, Balcaitis S, Cooper CJ, Fink PJ
  J Immunol. 2003
  PubMed ID: 14634147
   
  
• B7h is required for T cell activation, differentiation, and effector function.
  Nurieva RI, Mai XM, Forbush K, Bevan MJ, Dong C
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 14615582
   
  
• Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis.
  Lee WI, Zhu Q, Gambineri E, Jin Y, Welcher AA, Ochs HD
  J Allergy Clin Immunol. 2003
  PubMed ID: 14610488
   
  
• Regulation of immune and autoimmune responses by ICOS.
  Dong C, Nurieva RI
  J Autoimmun. 2003
  PubMed ID: 14599850
   
  
• PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.
  Okamoto N, Tezuka K, Kato M, Abe R, Tsuji T
  Biochem Biophys Res Commun. 2003
  PubMed ID: 14550257
   
  
• Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis.
  Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M
  J Immunol. 2003
  PubMed ID: 12960306
   
  
• Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy.
  Akalin E, Dikman S, Murphy B, Bromberg JS, Hancock WW
  Am J Transplant. 2003
  PubMed ID: 12919091
   
  
• Regulatory roles of IL-2 and IL-4 in H4/inducible costimulator expression on activated CD4+ T cells during Th cell development.
  Yagi J, Arimura Y, Dianzani U, Uede T, Okamoto T, Uchiyama T
  J Immunol. 2003
  PubMed ID: 12847246
   
  
• The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches.
  Iiyama R, Kanai T, Uraushihara K, Totsuka T, Nakamura T, Miyata T, Yagita H, Kushi A, Suzuki K, Tezuka K, Watanabe M
  Immunol Lett. 2003
  PubMed ID: 12853164
   
  
• The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosis.
  Wiendl H, Neuhaus O, Mehling M, Wintterle S, Schreiner B, Mitsdoerffer M, Wienhold W, Weissert R, Wessels J, Hartung HP, Weller M, Tolosa E, Melms A
  J Neuroimmunol. 2003
  PubMed ID: 12864987
   
  
• Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway.
  Futamatsu H, Suzuki J, Kosuge H, Yokoseki O, Kamada M, Ito H, Inobe M, Isobe M, Uede T
  Cardiovasc Res. 2003
  PubMed ID: 12829180
   
  
• Expression and function of the co-stimulator H4/ICOS on activated T cells of patients with rheumatoid arthritis.
  Okamoto T, Saito S, Yamanaka H, Tomatsu T, Kamatani N, Ogiuchi H, Uchiyama T, Yagi J
  J Rheumatol. 2003
  PubMed ID: 12784384
   
  
• Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation.
  Haaning Andersen AD, Lange M, Lillevang ST
  Tissue Antigens. 2003
  PubMed ID: 12753665
   
  
• Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells.
  Smith KM, Brewer JM, Webb P, Coyle AJ, Gutierrez-Ramos C, Garside P
  J Immunol. 2003
  PubMed ID: 12594252
   
  
• Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.
  Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA, Peter HH
  Nat Immunol. 2003
  PubMed ID: 12577056
   
  
• ICOS+ Th cells produce distinct cytokines in different mucosal immune responses.
  Bonhagen K, Liesenfeld O, Stadecker MJ, Hutloff A, Erb K, Coyle AJ, Lipp M, Kroczek RA, Kamradt T
  Eur J Immunol. 2003
  PubMed ID: 12645936
   
  
• A single amino acid alteration in cytoplasmic domain determines IL-2 promoter activation by ligation of CD28 but not inducible costimulator (ICOS).
  Harada Y, Ohgai D, Watanabe R, Okano K, Koiwai O, Tanabe K, Toma H, Altman A, Abe R
  J Exp Med. 2003
  PubMed ID: 12538664
   
  
• Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10.
  Löhning M, Hutloff A, Kallinich T, Mages HW, Bonhagen K, Radbruch A, Hamelmann E, Kroczek RA
  J Exp Med. 2003
  PubMed ID: 12538658
   
  
• Mechanisms of H4/ICOS costimulation: effects on proximal TCR signals and MAP kinase pathways.
  Feito MJ, Vaschetto R, Criado G, Sánchez A, Chiocchetti A, Jiménez-Periáñez A, Dianzani U, Portoles P, Rojo JM
  Eur J Immunol. 2003
  PubMed ID: 12594849
   
  
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12477932
   
  
• Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
  Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
  Nature. 2002
  PubMed ID: 12466851
   
  
• Initial sequencing and comparative analysis of the mouse genome.
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  Nature. 2002
  PubMed ID: 12466850
   
  
• Role of ICOS versus CD28 in antiviral immunity.
  Bertram EM, Tafuri A, Shahinian A, Chan VS, Hunziker L, Recher M, Ohashi PS, Mak TW, Watts TH
  Eur J Immunol. 2002
  PubMed ID: 12432568
   
  
• Inducible costimulator protein controls the protective T cell response against Listeria monocytogenes.
  Mittrücker HW, Kursar M, Köhler A, Yanagihara D, Yoshinaga SK, Kaufmann SH
  J Immunol. 2002
  PubMed ID: 12421962
   
  
• Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation.
  Iwai H, Kozono Y, Hirose S, Akiba H, Yagita H, Okumura K, Kohsaka H, Miyasaka N, Azuma M
  J Immunol. 2002
  PubMed ID: 12370365
   
  
• Inducible costimulator costimulates cytotoxic activity and IFN-gamma production in activated murine NK cells.
  Ogasawara K, Yoshinaga SK, Lanier LL
  J Immunol. 2002
  PubMed ID: 12244160
   
  
• Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors.
  Riley JL, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, Gregson BP, June CH, Linsley PS
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12195015
   
  
• ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells.
  Witsch EJ, Peiser M, Hutloff A, Büchner K, Dorner BG, Jonuleit H, Mages HW, Kroczek RA
  Eur J Immunol. 2002
  PubMed ID: 12207353
   
  
• Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity.
  Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT
  Nat Med. 2002
  PubMed ID: 12145647
   
  
• A role for inducible costimulator protein in the CD28- independent mechanism of resistance to Toxoplasma gondii.
  Villegas EN, Lieberman LA, Mason N, Blass SL, Zediak VP, Peach R, Horan T, Yoshinaga S, Hunter CA
  J Immunol. 2002
  PubMed ID: 12097399
   
  
• Inducible costimulator (ICOS).
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  J Biol Regul Homeost Agents. 2002
  PubMed ID: 12456021
   
  
• A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in T(h) cells and regulates their responses.
  Arimura Y, Kato H, Dianzani U, Okamoto T, Kamekura S, Buonfiglio D, Miyoshi-Akiyama T, Uchiyama T, Yagi J
  Int Immunol. 2002
  PubMed ID: 12039907
   
  
• Age-related change in thymic T-cell development is associated with genetic loci on mouse chromosomes 1, 3, and 11.
  Hsu HC, Mountz JD, Williams RW, Shelton BJ, Yang PA, Matsuki Y, Xu X, Dodd CH, Li L, Geiger H, Zhang HG, Van Zant G
  Mech Ageing Dev. 2002
  PubMed ID: 12044964
   
  
• Ligand binding sites of inducible costimulator and high avidity mutants with improved function.
  Wang S, Zhu G, Tamada K, Chen L, Bajorath J
  J Exp Med. 2002
  PubMed ID: 11956294
   
  
• Genetic polymorphism of the human ICOS gene.
  Haimila KE, Partanen JA, Holopainen PM
  Immunogenetics. 2002
  PubMed ID: 11904679
   
  
• Cutting edge: inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous leishmaniasis.
  Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH
  J Immunol. 2002
  PubMed ID: 11801630
   
  
• Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches.
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  Genomics. 2001
  PubMed ID: 11735222
   
  
• A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice.
  Farmer MA, Sundberg JP, Bristol IJ, Churchill GA, Li R, Elson CO, Leiter EH
  Proc Natl Acad Sci U S A. 2001
  PubMed ID: 11707574
   
  
• Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease.
  Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI
  J Immunol. 2001
  PubMed ID: 11489981
   
  
• Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.
  Ozkaynak E, Gao W, Shemmeri N, Wang C, Gutierrez-Ramos JC, Amaral J, Qin S, Rottman JB, Coyle AJ, Hancock WW
  Nat Immunol. 2001
  PubMed ID: 11429542
   
  
• Cutting edge: critical role of inducible costimulator in germinal center reactions.
  Dong C, Temann UA, Flavell RA
  J Immunol. 2001
  PubMed ID: 11238604
   
  
• Functional annotation of a full-length mouse cDNA collection.
  Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
  Nature. 2001
  PubMed ID: 11217851
   
  
• ICOS is essential for effective T-helper-cell responses.
  Tafuri A, Shahinian A, Bladt F, Yoshinaga SK, Jordana M, Wakeham A, Boucher LM, Bouchard D, Chan VS, Duncan G, Odermatt B, Ho A, Itie A, Horan T, Whoriskey JS, Pawson T, Penninger JM, Ohashi PS, Mak TW
  Nature. 2001
  PubMed ID: 11343123
   
  
• ICOS is critical for CD40-mediated antibody class switching.
  McAdam AJ, Greenwald RJ, Levin MA, Chernova T, Malenkovich N, Ling V, Freeman GJ, Sharpe AH
  Nature. 2001
  PubMed ID: 11343122
   
  
• ICOS co-stimulatory receptor is essential for T-cell activation and function.
  Dong C, Juedes AE, Temann UA, Shresta S, Allison JP, Ruddle NH, Flavell RA
  Nature. 2001
  PubMed ID: 11343121
   
  
• Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies.
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  Clin Rheumatol. 2001
  PubMed ID: 11771526
   
  
• Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production.
  Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R
  J Exp Med. 2000
  PubMed ID: 11104797
   
  
• Induction, binding specificity and function of human ICOS.
  Beier KC, Hutloff A, Dittrich AM, Heuck C, Rauch A, Büchner K, Ludewig B, Ochs HD, Mages HW, Kroczek RA
  Eur J Immunol. 2000
  PubMed ID: 11169414
   
  
• RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
  Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
  Genome Res. 2000
  PubMed ID: 11076861
   
  
• Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS.
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  Blood. 2000
  PubMed ID: 11023515
   
  
• Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
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  Genome Res. 2000
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• Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family.
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