HIPK2

Summary Top Help

Gene Description:

homeodomain interacting protein kinase 2

Synonyms:

PRO0593, Stank, HIPK2, 1110014O20Rik, Hipk2, B230339E18Rik

Orthologs:

Human HIPK2 (protein-coding), Mouse Hipk2 (protein-coding), Rat Hipk2 (protein-coding)

Sources

Overlapping regions from T1DBase Curated Regions Top Help

Regions Overlapping this Feature: Rat: 3

Linkage Regions: 1 Available

Locus	Species	Chromosomal Location	Mb	Number of genes	Linkage and Congenic Studies
Mordes Iddm4	Rat	chr4:64510953..70123393	5.61	72	1 Non-significant for backcross, 3 Significant for backcross, 1 no lod score

Other Regions: 2 Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Iddm14	Rat	chr4:63276741..160891592	97.61	815
Iddm11	Rat	chr4:56920444..78042833	21.12	213

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr7:139246316..139477693 (231.38 kb) View in Genome Browser

(Mouse) NCBIM37 - chr6:38644389..38826189 (181.80 kb) View in Genome Browser

(Rat) RGSC3.4 - chr4:66273623..66455774 (182.15 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for HIPK2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for HIPK2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

Gene Ontology: 53

Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Nucleotide binding	GO:0000166
RNA polymerase II activating transcription factor binding	GO:0001102
RNA polymerase II transcription coactivator activity	GO:0001105
Eye development	GO:0001654
Transcription corepressor activity	GO:0003714
Protein kinase activity	GO:0004672
Protein serine/threonine kinase activity	GO:0004674
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Centrosome	GO:0005813
Protein phosphorylation	GO:0006468
Apoptotic process	GO:0006915
Response to DNA damage stimulus	GO:0006974
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978
Smoothened signaling pathway	GO:0007224
Adult walking behavior	GO:0007628
Positive regulation of cell proliferation	GO:0008284
Induction of apoptosis by intracellular signals	GO:0008629
Anterior/posterior pattern specification	GO:0009952
Retina layer formation	GO:0010842
Nuclear body	GO:0016604
PML body	GO:0016605
Peptidyl-serine phosphorylation	GO:0018105
Peptidyl-threonine phosphorylation	GO:0018107
Virus-host interaction	GO:0019048
Neuron differentiation	GO:0030182
Erythrocyte differentiation	GO:0030218
Positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511
Negative regulation of BMP signaling pathway	GO:0030514
PML body organization	GO:0030578
Nuclear membrane	GO:0031965
Positive regulation of protein binding	GO:0032092
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771
Positive regulation of DNA binding	GO:0043388
Negative regulation of neuron apoptosis	GO:0043524
Positive regulation of angiogenesis	GO:0045766
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of JNK cascade	GO:0046330
SMAD binding	GO:0046332
Virion binding	GO:0046790
Embryonic camera-type eye morphogenesis	GO:0048596
Voluntary musculoskeletal movement	GO:0050882
Positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091
Regulation of cell cycle	GO:0051726
Embryonic retina morphogenesis in camera-type eye	GO:0060059
Lens induction in camera-type eye	GO:0060235
SMAD protein signal transduction	GO:0060395
Iris morphogenesis	GO:0061072
Cellular response to hypoxia	GO:0071456

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: 2

C-MYB transcription factor network

p53 pathway

Gene Ontology: 53
Negative regulation of transcription from RNA polymerase II promoter	GO:0000122
Nucleotide binding	GO:0000166
RNA polymerase II activating transcription factor binding	GO:0001102
RNA polymerase II transcription coactivator activity	GO:0001105
Eye development	GO:0001654
Transcription corepressor activity	GO:0003714
Protein kinase activity	GO:0004672
Protein serine/threonine kinase activity	GO:0004674
Protein binding	GO:0005515
ATP binding	GO:0005524
Nucleus	GO:0005634
Cytoplasm	GO:0005737
Centrosome	GO:0005813
Protein phosphorylation	GO:0006468
Apoptotic process	GO:0006915
Response to DNA damage stimulus	GO:0006974
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978
Smoothened signaling pathway	GO:0007224
Adult walking behavior	GO:0007628
Positive regulation of cell proliferation	GO:0008284
Induction of apoptosis by intracellular signals	GO:0008629
Anterior/posterior pattern specification	GO:0009952
Retina layer formation	GO:0010842
Nuclear body	GO:0016604
PML body	GO:0016605
Peptidyl-serine phosphorylation	GO:0018105
Peptidyl-threonine phosphorylation	GO:0018107
Virus-host interaction	GO:0019048
Neuron differentiation	GO:0030182
Erythrocyte differentiation	GO:0030218
Positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511
Negative regulation of BMP signaling pathway	GO:0030514
PML body organization	GO:0030578
Nuclear membrane	GO:0031965
Positive regulation of protein binding	GO:0032092
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	GO:0042771
Positive regulation of DNA binding	GO:0043388
Negative regulation of neuron apoptosis	GO:0043524
Positive regulation of angiogenesis	GO:0045766
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Positive regulation of JNK cascade	GO:0046330
SMAD binding	GO:0046332
Virion binding	GO:0046790
Embryonic camera-type eye morphogenesis	GO:0048596
Voluntary musculoskeletal movement	GO:0050882
Positive regulation of sequence-specific DNA binding transcription factor activity	GO:0051091
Regulation of cell cycle	GO:0051726
Embryonic retina morphogenesis in camera-type eye	GO:0060059
Lens induction in camera-type eye	GO:0060235
SMAD protein signal transduction	GO:0060395
Iris morphogenesis	GO:0061072
Cellular response to hypoxia	GO:0071456

Publications from PubMed Top Help

Type 1 Diabetes Publications: 3

Publications: 147

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.
Lazzari C, Prodosmo A, Siepi F, Rinaldo C, Galli F, Gentileschi M, Bartolazzi A, Costanzo A, Sacchi A, Guerrini L, Soddu S
Oncogene. 2011
PubMed ID: 21602882
Homeodomain interacting protein kinase 2 regulates postnatal development of enteric dopaminergic neurons and glia via BMP signaling.
Chalazonitis A, Tang AA, Shang Y, Pham TD, Hsieh I, Setlik W, Gershon MD, Huang EJ
J Neurosci. 2011
PubMed ID: 21957238
Homeodomain-interacting protein kinase-2 stabilizes p27(kip1) by its phosphorylation at serine 10 and contributes to cell motility.
Pierantoni GM, Esposito F, Tornincasa M, Rinaldo C, Viglietto G, Soddu S, Fusco A
J Biol Chem. 2011
PubMed ID: 21715331
Mutational analysis of the HIPK2 gene in keratoacanthoma and squamous cell carcinoma of the skin.
Cao Z, Yoon JH, Nam SW, Lee JY, Park WS
APMIS. 2011
PubMed ID: 21569099
Tissue microarray cytometry reveals positive impact of homeodomain interacting protein kinase 2 in colon cancer survival irrespective of p53 function.
Soubeyran I, Mahouche I, Grigoletto A, Leste-Lasserre T, Drutel G, Rey C, Pedeboscq S, Blanchard F, Brouste V, Sabourin JC, Bécouarn Y, Reiffers J, Ichas F, De Giorgi F
Am J Pathol. 2011
PubMed ID: 21514416
Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.
Sung KS, Lee YA, Kim ET, Lee SR, Ahn JH, Choi CY
Exp Cell Res. 2011
PubMed ID: 21192925
Phosphorylation of TCF proteins by homeodomain-interacting protein kinase 2.
Hikasa H, Sokol SY
J Biol Chem. 2011
PubMed ID: 21285352
Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis.
Crone J, Glas C, Schultheiss K, Moehlenbrink J, Krieghoff-Henning E, Hofmann TG
Cancer Res. 2011
PubMed ID: 21248071
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC
Oncogene. 2011
PubMed ID: 21057547
Control of nuclear HIPK2 localization and function by a SUMO interaction motif.
de la Vega L, Fröbius K, Moreno R, Calzado MA, Geng H, Schmitz ML
Biochim Biophys Acta. 2011
PubMed ID: 21145359
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation.
Nardinocchi L, Puca R, D'Orazi G
Aging (Albany NY). 2011
PubMed ID: 21248371
MYCN sensitizes human neuroblastoma to apoptosis by HIPK2 activation through a DNA damage response.
Petroni M, Veschi V, Prodosmo A, Rinaldo C, Massimi I, Carbonari M, Dominici C, McDowell HP, Rinaldi C, Screpanti I, Frati L, Bartolazzi A, Gulino A, Soddu S, Giannini G
Mol Cancer Res. 2011
PubMed ID: 21173028
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.
Ritterhoff S, Farah CM, Grabitzki J, Lochnit G, Skurat AV, Schmitz ML
EMBO J. 2010
PubMed ID: 20940704
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress.
Hailemariam K, Iwasaki K, Huang BW, Sakamoto K, Tsuji Y
J Cell Sci. 2010
PubMed ID: 20980392
Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells.
Nardinocchi L, Puca R, Givol D, D'Orazi G
FEBS Lett. 2010
PubMed ID: 20849851
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
MiR-27a modulates MDR1/P-glycoprotein expression by targeting HIPK2 in human ovarian cancer cells.
Li Z, Hu S, Wang J, Cai J, Xiao L, Yu L, Wang Z
Gynecol Oncol. 2010
PubMed ID: 20624637
Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.
Sakamoto K, Huang BW, Iwasaki K, Hailemariam K, Ninomiya-Tsuji J, Tsuji Y
Mol Biol Cell. 2010
PubMed ID: 20573984
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.
Puca R, Nardinocchi L, Givol D, D'Orazi G
Oncogene. 2010
PubMed ID: 20514025
Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis.
Inoue T, Kagawa T, Inoue-Mochita M, Isono K, Ohtsu N, Nobuhisa I, Fukushima M, Tanihara H, Taga T
FEBS Lett. 2010
PubMed ID: 20579985
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas.
Tsuruyama T, Imai Y, Takeuchi H, Hiratsuka T, Maruyama Y, Kanaya K, Kaszynski R, Jin G, Okuno T, Ozeki M, Nakamura T, Takakuwa T, Manabe T, Tamaki K, Hiai H
J Leukoc Biol. 2010
PubMed ID: 20360400
Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation.
Hattangadi SM, Burke KA, Lodish HF
Blood. 2010
PubMed ID: 20231426
Homeodomain-interacting protein kinase 2 (HIPK2) targets beta-catenin for phosphorylation and proteasomal degradation.
Kim EA, Kim JE, Sung KS, Choi DW, Lee BJ, Choi CY
Biochem Biophys Res Commun. 2010
PubMed ID: 20307497
HIPK2-a therapeutical target to be (re)activated for tumor suppression: role in p53 activation and HIF-1α inhibition.
Nardinocchi L, Puca R, Givol D, D'Orazi G
Cell Cycle. 2010
PubMed ID: 20234185
A transposon in comt generates mRNA variants and causes widespread expression and behavioral differences among mice.
Li Z, Mulligan MK, Wang X, Miles MF, Lu L, Williams RW
PLoS One. 2010
PubMed ID: 20808911
Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival.
Lanni C, Nardinocchi L, Puca R, Stanga S, Uberti D, Memo M, Govoni S, D'Orazi G, Racchi M
PLoS One. 2010
PubMed ID: 20418953
Methyl-CpG-binding protein 2 is phosphorylated by homeodomain-interacting protein kinase 2 and contributes to apoptosis.
Bracaglia G, Conca B, Bergo A, Rusconi L, Zhou Z, Greenberg ME, Landsberger N, Soddu S, Kilstrup-Nielsen C
EMBO Rep. 2009
PubMed ID: 19820693
Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.
Li H, Costantini C, Scrable H, Weindruch R, Puglielli L
Neurobiol Aging. 2009
PubMed ID: 18378044
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA, Nagarajan R, Gutmann DH
Neurology. 2009
PubMed ID: 19794125
Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling - roles of p53, p73 and HIPK2.
Bitomsky N, Hofmann TG
FEBS J. 2009
PubMed ID: 19788416
Autoregulatory control of the p53 response by Siah-1L-mediated HIPK2 degradation.
Calzado MA, de la Vega L, Muñoz E, Schmitz ML
Biol Chem. 2009
PubMed ID: 19642869
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.
Heibeck TH, Ding SJ, Opresko LK, Zhao R, Schepmoes AA, Yang F, Tolmachev AV, Monroe ME, Camp DG, Smith RD, Wiley HS, Qian WJ
J Proteome Res. 2009
PubMed ID: 19534553
Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.
McDonough H, Charles PC, Hilliard EG, Qian SB, Min JN, Portbury A, Cyr DM, Patterson C
J Biol Chem. 2009
PubMed ID: 19465479
Negative regulation of beta4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 impairs tumor progression.
Bon G, Di Carlo SE, Folgiero V, Avetrani P, Lazzari C, D'Orazi G, Brizzi MF, Sacchi A, Soddu S, Blandino G, Mottolese M, Falcioni R
Cancer Res. 2009
PubMed ID: 19567674
The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4.
Yamada D, Pérez-Torrado R, Filion G, Caly M, Jammart B, Devignot V, Sasai N, Ravassard P, Mallet J, Sastre-Garau X, Schmitz ML, Defossez PA
Oncogene. 2009
PubMed ID: 19448668
Large-scale proteomics analysis of the human kinome.
Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Kéri G, Mann M, Daub H
Mol Cell Proteomics. 2009
PubMed ID: 19369195
[Correlation of HIPK2 expression with HPV infection and apoptosis in cervical cancer].
Al-Beiti MA, Lu X, Liu XS
Zhonghua Zhong Liu Za Zhi. 2009
PubMed ID: 19950553
HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.
Iacovelli S, Ciuffini L, Lazzari C, Bracaglia G, Rinaldo C, Prodosmo A, Bartolazzi A, Sacchi A, Soddu S
Cell Prolif. 2009
PubMed ID: 19438900
Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.
Trapasso F, Aqeilan RI, Iuliano R, Visone R, Gaudio E, Ciuffini L, Alder H, Paduano F, Pierantoni GM, Soddu S, Croce CM, Fusco A
DNA Cell Biol. 2009
PubMed ID: 19364276
PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML
Oncogene. 2009
PubMed ID: 19015637
Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.
Nardinocchi L, Puca R, Guidolin D, Belloni AS, Bossi G, Michiels C, Sacchi A, Onisto M, D'Orazi G
Biochim Biophys Acta. 2009
PubMed ID: 19046997
How cells switch HIPK2 on and off.
Sombroek D, Hofmann TG
Cell Death Differ. 2009
PubMed ID: 18974774
HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Puca R, Nardinocchi L, Sacchi A, Rechavi G, Givol D, D'Orazi G
Mol Cancer. 2009
PubMed ID: 19828042
Targeting hypoxia in cancer cells by restoring homeodomain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha.
Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, D'Orazi G
PLoS One. 2009
PubMed ID: 19714248
Homeodomain interacting protein kinase 2 activation compromises endothelial cell response to laminar flow: protective role of p21(waf1,cip1,sdi1).
Mattiussi S, Lazzari C, Truffa S, Antonini A, Soddu S, Capogrossi MC, Gaetano C
PLoS One. 2009
PubMed ID: 19668373
Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis.
Nardinocchi L, Puca R, Sacchi A, D'Orazi G
Mol Cancer. 2009
PubMed ID: 19128456
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.
Calzado MA, de la Vega L, Möller A, Bowtell DD, Schmitz ML
Nat Cell Biol. 2009
PubMed ID: 19043406
Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.
Puca R, Nardinocchi L, Bossi G, Sacchi A, Rechavi G, Givol D, D'Orazi G
Exp Cell Res. 2009
PubMed ID: 18996371
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I
Mol Cell Biol. 2008
PubMed ID: 18809579
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation.
Kanei-Ishii C, Nomura T, Takagi T, Watanabe N, Nakayama KI, Ishii S
J Biol Chem. 2008
PubMed ID: 18765672
PEBP2-beta/CBF-beta-dependent phosphorylation of RUNX1 and p300 by HIPK2: implications for leukemogenesis.
Wee HJ, Voon DC, Bae SC, Ito Y
Blood. 2008
PubMed ID: 18695000
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.
Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR, Watson MA, Gutmann DH, Nagarajan R
Oncogene. 2008
PubMed ID: 18408760
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
Seebahn A, Rose M, Enz R
FEBS Lett. 2008
PubMed ID: 18555800
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
Winter M, Sombroek D, Dauth I, Moehlenbrink J, Scheuermann K, Crone J, Hofmann TG
Nat Cell Biol. 2008
PubMed ID: 18536714
Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells.
Puca R, Nardinocchi L, Pistritto G, D'Orazi G
Gynecol Oncol. 2008
PubMed ID: 18395248
Reversible dysfunction of wild-type p53 following homeodomain-interacting protein kinase-2 knockdown.
Puca R, Nardinocchi L, Gal H, Rechavi G, Amariglio N, Domany E, Notterman DA, Scarsella M, Leonetti C, Sacchi A, Blandino G, Givol D, D'Orazi G
Cancer Res. 2008
PubMed ID: 18483253
Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.
Choi DW, Seo YM, Kim EA, Sung KS, Ahn JW, Park SJ, Lee SR, Choi CY
J Biol Chem. 2008
PubMed ID: 18093972
Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2.
Puca R, Nardinocchi L, D'Orazi G
J Exp Clin Cancer Res. 2008
PubMed ID: 18644116
Gene mapping of sperm quality parameters in recombinant inbred strains of mice.
Golas A, Dzieza A, Kuzniarz K, Styrna J
Int J Dev Biol. 2008
PubMed ID: 18311719
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.
Ballif BA, Carey GR, Sunyaev SR, Gygi SP
J Proteome Res. 2008
PubMed ID: 18034455
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ
Cell. 2007
PubMed ID: 18083107
Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity.
Zhang Q, Wang Y
J Proteome Res. 2007
PubMed ID: 17960875
Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription.
Li XL, Arai Y, Harada H, Shima Y, Yoshida H, Rokudai S, Aikawa Y, Kimura A, Kitabayashi I
Oncogene. 2007
PubMed ID: 17533375
HIPK2-induced p53Ser46 phosphorylation activates the KILLER/DR5-mediated caspase-8 extrinsic apoptotic pathway.
Pistritto G, Puca R, Nardinocchi L, Sacchi A, D'Orazi G
Cell Death Differ. 2007
PubMed ID: 17627287
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Wei G, Ku S, Ma GK, Saito S, Tang AA, Zhang J, Mao JH, Appella E, Balmain A, Huang EJ
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17666529
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.
Rinaldo C, Prodosmo A, Mancini F, Iacovelli S, Sacchi A, Moretti F, Soddu S
Mol Cell. 2007
PubMed ID: 17349959
Patterns of somatic mutation in human cancer genomes.
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR
Nature. 2007
PubMed ID: 17344846
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.
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Cancer Res. 2007
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High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.
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J Clin Invest. 2007
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Cell Cycle. 2007
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Nat Neurosci. 2007
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Inhibitory effects of homeodomain-interacting protein kinase 2 on the aorta-gonad-mesonephros hematopoiesis.
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Exp Cell Res. 2007
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Mol Cell Biol. 2006
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Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis.
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Cell Death Differ. 2006
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Mol Cell. 2006
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A global genomic transcriptional code associated with CNS-expressed genes.
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EMBO J. 2006
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A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
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Genomics. 2006
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Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis.
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Mol Cell Biol. 2006
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EMBO J. 2006
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Mol Cell Biol. 2006
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Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.
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J Biol Chem. 2006
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Homeodomain-interacting protein kinase-2 restrains cytosolic phospholipase A2-dependent prostaglandin E2 generation in human colorectal cancer cells.
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Clin Cancer Res. 2006
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FHL2 mediates p53-induced transcriptional activation through a direct association with HIPK2.
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Biochem Biophys Res Commun. 2006
PubMed ID: 16343438
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FEBS Lett. 2005
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HIPK2 inhibits both MDM2 gene and protein by, respectively, p53-dependent and independent regulations.
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FEBS Lett. 2005
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The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.
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Mol Biol Cell. 2005
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Science. 2005
PubMed ID: 16141073
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Science. 2005
PubMed ID: 16141072
Regulation of homeodomain-interacting protein kinase 2 (HIPK2) effector function through dynamic small ubiquitin-related modifier-1 (SUMO-1) modification.
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J Biol Chem. 2005
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FEBS Lett. 2005
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Covalent modification of human homeodomain interacting protein kinase 2 by SUMO-1 at lysine 25 affects its stability.
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Biochem Biophys Res Commun. 2005
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Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis.
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Proc Natl Acad Sci U S A. 2005
PubMed ID: 15708980
Gene and alternative splicing annotation with AIR.
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Genome Res. 2005
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Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.
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EMBO J. 2004
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Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.
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J Cell Biol. 2004
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HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function.
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Oncogene. 2004
PubMed ID: 15122315
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.
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Nat Biotechnol. 2004
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Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK.
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Genes Dev. 2004
PubMed ID: 15082531
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Nature. 2004
PubMed ID: 15057822
US11 of herpes simplex virus type 1 interacts with HIPK2 and antagonizes HIPK2-induced cell growth arrest.
Giraud S, Diaz-Latoud C, Hacot S, Textoris J, Bourette RP, Diaz JJ
J Virol. 2004
PubMed ID: 14990717
GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM
Genomics. 2004
PubMed ID: 14667819
HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.
Hofmann TG, Stollberg N, Schmitz ML, Will H
Cancer Res. 2003
PubMed ID: 14678985
Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules.
Lee BH, Yoshimatsu K, Maeda A, Ochiai K, Morimatsu M, Araki K, Ogino M, Morikawa S, Arikawa J
Virus Res. 2003
PubMed ID: 14609633
Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.
Möller A, Sirma H, Hofmann TG, Staege H, Gresko E, Lüdi KS, Klimczak E, Dröge W, Will H, Schmitz ML
Oncogene. 2003
PubMed ID: 14647468
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.
Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH
Cell. 2003
PubMed ID: 14567915
Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation.
Harada J, Kokura K, Kanei-Ishii C, Nomura T, Khan MM, Kim Y, Ishii S
J Biol Chem. 2003
PubMed ID: 12874272
TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.
Tomasini R, Samir AA, Carrier A, Isnardon D, Cecchinelli B, Soddu S, Malissen B, Dagorn JC, Iovanna JL, Dusetti NJ
J Biol Chem. 2003
PubMed ID: 12851404
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains.
Möller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Dröge W, Will H, Schmitz ML
Cancer Res. 2003
PubMed ID: 12907596
The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
Human chromosome 7: DNA sequence and biology.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
Science. 2003
PubMed ID: 12690205
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.
Ecsedy JA, Michaelson JS, Leder P
Mol Cell Biol. 2003
PubMed ID: 12529400
Viruses as hijackers of PML nuclear bodies.
Möller A, Schmitz ML
Arch Immunol Ther Exp (Warsz). 2003
PubMed ID: 14626429
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
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Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
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Nature. 2002
PubMed ID: 12466851
HIPK2 associates with RanBPM.
Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H
Biochem Biophys Res Commun. 2002
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Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.
Kim EJ, Park JS, Um SJ
J Biol Chem. 2002
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ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.
Saito S, Goodarzi AA, Higashimoto Y, Noda Y, Lees-Miller SP, Appella E, Anderson CW
J Biol Chem. 2002
PubMed ID: 11875057
The homeodomain-interacting protein kinase 2 gene is expressed late in embryogenesis and preferentially in retina, muscle, and neural tissues.
Pierantoni GM, Bulfone A, Pentimalli F, Fedele M, Iuliano R, Santoro M, Chiariotti L, Ballabio A, Fusco A
Biochem Biophys Res Commun. 2002
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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.
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Nat Cell Biol. 2002
PubMed ID: 11780126
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.
Hofmann TG, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, Will H, Schmitz ML
Nat Cell Biol. 2002
PubMed ID: 11740489
High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth.
Pierantoni GM, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G, Santoro M, Chiariotti L, Fusco A
Oncogene. 2001
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The DNA glycosylase T:G mismatch-specific thymine DNA glycosylase represses thyroid transcription factor-1-activated transcription.
Missero C, Pirro MT, Simeone S, Pischetola M, Di Lauro R
J Biol Chem. 2001
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Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.
Piao Y, Ko NT, Lim MK, Ko MS
Genome Res. 2001
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Isolation and characterization of cDNAs for the protein kinase HIPK2.
Wang Y, Hofmann TG, Runkel L, Haaf T, Schaller H, Debatin K, Hug H
Biochim Biophys Acta. 2001
PubMed ID: 11267674
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels.
Wang Y, Debatin KM, Hug H
BMC Mol Biol. 2001
PubMed ID: 11532197
Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.
Hofmann TG, Mincheva A, Lichter P, Dröge W, Schmitz ML
Biochimie. 2000
PubMed ID: 11120354
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.
Li X, Wang Y, Debatin KM, Hug H
Biochem Biophys Res Commun. 2000
PubMed ID: 11032752
Identification and cloning of a CD43-associated serine/threonine kinase.
Wang W, Link V, Green JM
Cell Immunol. 2000
PubMed ID: 11078605
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Estrogenic induction of spermatogenesis in the hypogonadal mouse.
Ebling FJ, Brooks AN, Cronin AS, Ford H, Kerr JB
Endocrinology. 2000
PubMed ID: 10919273
The homeodomain protein NK-3 recruits Groucho and a histone deacetylase complex to repress transcription.
Choi CY, Kim YH, Kwon HJ, Kim Y
J Biol Chem. 1999
PubMed ID: 10559189
Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.
Kim YH, Choi CY, Kim Y
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10535925
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Toward a complete human genome sequence.

Genome Res. 1998
PubMed ID: 9847074
Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors.
Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y
J Biol Chem. 1998
PubMed ID: 9748262
Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	28996	15258	362342
EnsEMBL Gene(s)	ENSG00000064393	ENSMUSG00000061436	ENSRNOG00000007034
Unigene	Hs.731417	Mm.23790	Rn.219795
Homologene	HIPK2	Hipk2	Hipk2
OMIM	606868	N/A	N/A
GeneCards	HIPK2	N/A	N/A
Beta Cell Genomics	DT.100747919 DT.75187665	DT.101384952 DT.60118111 DT.87072430 DT.91333823 DT.91335367 DT.91352667 DT.91416521 DT.97409666	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	28996	15258	362342

External resources from NIDDK Consortium Interconnectivity Network Top Help

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
HIPK2	RANBP9	HPRD, BioGRID	empirical	12220523
HIPK2	DDX39A	HPRD	empirical	14667819
HIPK2	CHMP4B	HPRD	empirical	16730941
HIPK2	CREBBP	HPRD, BioGRID	empirical	11740489
HIPK2	NKX2-5	HPRD	empirical	9748262
HIPK2	CTBP2	BioGRID	empirical	16940173
HIPK2	DAXX	HPRD, BioGRID	empirical	14678985 19465479
HIPK2	EP300	MINT, BioGRID	empirical	16917507
HIPK2	WSB1	IntAct, BioGRID	empirical	18093972
HIPK2	HIPK2	HPRD, BioGRID	empirical	14667819 16917507
HIPK2	GRM8	BioGRID	empirical	18555800
HIPK2	CXCL1	BioGRID	empirical	15896780
HIPK2	HMGA1	HPRD, IntAct	empirical	11593421 17960875
HIPK2	SIAH1P1	BioGRID	empirical	19642869
HIPK2	SKOR1	IntAct	empirical	15528197
HIPK2	SMAD1	HPRD, BioGRID	empirical	12874272
HIPK2	SMAD2	HPRD, BioGRID	empirical	12874272
HIPK2	SMAD3	BioGRID	empirical	12874272
HIPK2	MDM2	HPRD, MINT	empirical	16212962
HIPK2	MYB	HPRD, IntAct, BioGRID	empirical	15082531 16055500
HIPK2	MYBL1	BioGRID	empirical	16055500
HIPK2	MYBL2	BioGRID	empirical	16055500
HIPK2	NKX3-1	HPRD	empirical	10559189
HIPK2	PAX6	HPRD	empirical	16407227
HIPK2	NLK	HPRD, IntAct, BioGRID	empirical	15082531
HIPK2	PML	IntAct, BioGRID	empirical	21057547
HIPK2	FBXW7	HPRD	empirical	18765672
HIPK2	PTCH1	HPRD	empirical	12874272
HIPK2	SIAH1	BioGRID	empirical	19043406
HIPK2	SIAH2	BioGRID	empirical	19043406
HIPK2	SKI	HPRD, BioGRID	empirical	12874272
HIPK2	SP100	HPRD, BioGRID	empirical	14647468
HIPK2	MAP3K7	HPRD, BioGRID	empirical	15082531
HIPK2	NKX2-1	HPRD	empirical	11438542
HIPK2	TLE1	MINT	empirical	15896780
HIPK2	TP53	HPRD, MINT, IntAct, BioGRID	empirical	11925430 11780126 11875057 15896780 16212962 21057547 11740489
HIPK2	TP73	HPRD, BioGRID	empirical	11925430
HIPK2	UBC	BioGRID	empirical	19043406 21906983
HIPK2	UBE2I	HPRD, MINT, IntAct, BioGRID	empirical	14609633 10535925 15896780 19549727 20936779
HIPK2	SUMO1	HPRD, MINT	empirical	14609633 10535925 15896780
HIPK2	DDX39B	HPRD, IntAct	empirical	14667819
HIPK2	AXIN1	IntAct, BioGRID	empirical	21057547
HIPK2	CUL1	HPRD, BioGRID	empirical	18765672
HIPK2	MKNK1	IntAct	empirical	21988832
HIPK2	RUNX1	HPRD, MINT, BioGRID	empirical	16917507
HIPK2	TP63	HPRD	empirical	11925430
HIPK2	TRADD	HPRD, BioGRID	empirical	11032752
HIPK2	KAT2B	HPRD	empirical	16917507
HIPK2	BTRC	HPRD, BioGRID	empirical	18765672
HIPK2	TP53INP1	HPRD, BioGRID	empirical	12851404