Home GRN
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(Human) GRCh37 - chr17:42422491..42430470 (7.98 kb) View in Genome Browser
(Mouse) NCBIM37 - chr11:102291629..102298362 (6.73 kb) View in Genome Browser
(Rat) RGSC3.4 - chr10:91536135..91542239 (6.10 kb) View in Genome Browser
HaemAtlas Expression Table for GRN:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for GRN:The GRN interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| GRN | FRAT1 | IntAct | empirical | 21988832 |
| GRN | CDK9 | HPRD, BioGRID | empirical | 12588988 |
| GRN | CFTR | IntAct | empirical | 17110338 |
| GRN | CRKL | IntAct | empirical | 18654987 |
| GRN | CRY1 | IntAct | empirical | 21988832 |
| GRN | ATN1 | HPRD, MINT, IntAct | empirical | 16713569 |
| GRN | ELANE | HPRD | empirical | 12526812 |
| GRN | SIRT3 | IntAct, BioGRID | empirical | 19343720 |
| GRN | POT1 | IntAct | empirical | 21988832 |
| GRN | GRIA2 | IntAct | empirical | 19022416 |
| GRN | HK3 | HPRD, BioGRID | empirical | 11068878 |
| GRN | HOXA1 | HPRD, MINT, IntAct, BioGRID | empirical | 16189514 |
| GRN | HSPG2 | HPRD, MINT | empirical | 12900424 |
| GRN | FAM131C | HPRD, IntAct, BioGRID | empirical | 16189514 |
| GRN | KCNQ2 | IntAct | empirical | 19022416 |
| GRN | KRT18 | IntAct | empirical | 21988832 |
| GRN | SMAD9 | HPRD, MINT | empirical | 15231748 |
| GRN | PIK3R2 | IntAct | empirical | 21988832 |
| GRN | PRKAA1 | IntAct | empirical | 20368287 |
| GRN | PRKAB2 | IntAct | empirical | 21988832 |
| GRN | TRIB3 | BioGRID | empirical | 18276110 |
| GRN | RAC1 | IntAct | empirical | 21988832 |
| GRN | ATXN7 | BioGRID | empirical | 21078624 |
| GRN | SLPI | HPRD, BioGRID | empirical | 12526812 |
| GRN | TAT | BioGRID | empirical | 12588988 |
| GRN | TGM2 | IntAct | empirical | 21988832 |
| GRN | VHL | BioGRID | empirical | 21942715 |
| GRN | YY1 | IntAct | empirical | 21988832 |
| GRN | GFI1B | HPRD, MINT, IntAct | empirical | 16713569 |
| GRN | DLK1 | HPRD, BioGRID | empirical | 11846389 |
| GRN | TOP3B | HPRD, BioGRID | empirical | 11549288 |
| GRN | CCNG1 | IntAct | empirical | 21988832 |
| GRN | CCNT1 | HPRD, BioGRID | empirical | 12588988 |
| GRN | KIAA0101 | BioGRID | empirical | 21628590 |
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Publications: 255
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Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an Akt-dependent mechanism.
Frampton G, Invernizzi P, Bernuzzi F, Pae HY, Quinn M, Horvat D, Galindo C, Huang L, McMillin M, Cooper B, Rimassa L, DeMorrow S
Gut. 2012
PubMed ID: 22068162
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Core features of frontotemporal dementia recapitulated in progranulin knockout mice.
Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ
Neurobiol Dis. 2012
PubMed ID: 21933710
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Involvement of progranulin in hypothalamic glucose sensing and feeding regulation.
Kim HK, Shin MS, Youn BS, Namkoong C, Gil SY, Kang GM, Yu JH, Kim MS
Endocrinology. 2011
PubMed ID: 21933869
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Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y
J Proteome Res. 2011
PubMed ID: 21942715
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Upregulation of progranulin by Helicobacter pylori in human gastric epithelial cells via p38MAPK and MEK1/2 signaling pathway: role in epithelial cell proliferation and migration.
Wang H, Sun Y, Liu S, Yu H, Li W, Zeng J, Chen C, Jia J
FEMS Immunol Med Microbiol. 2011
PubMed ID: 21707777
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Progranulin expression in brain tissue and cerebrospinal fluid levels in multiple sclerosis.
Vercellino M, Grifoni S, Romagnolo A, Masera S, Mattioda A, Trebini C, Chiavazza C, Caligiana L, Capello E, Mancardi GL, Giobbe D, Mutani R, Giordana MT, Cavalla P
Mult Scler. 2011
PubMed ID: 21613335
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Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling.
Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH
Neuron. 2011
PubMed ID: 21943601
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Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses.
Tapia L, Milnerwood A, Guo A, Mills F, Yoshida E, Vasuta C, Mackenzie IR, Raymond L, Cynader M, Jia W, Bamji SX
J Neurosci. 2011
PubMed ID: 21813674
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Trajectories of brain and hippocampal atrophy in FTD with mutations in MAPT or GRN.
Whitwell JL, Weigand SD, Gunter JL, Boeve BF, Rademakers R, Baker M, Knopman DS, Wszolek ZK, Petersen RC, Jack CR, Josephs KA
Neurology. 2011
PubMed ID: 21753165
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Proepithelin stimulates growth plate chondrogenesis via nuclear factor-kappaB-p65-dependent mechanisms.
Wu S, Zang W, Li X, Sun H
J Biol Chem. 2011
PubMed ID: 21566130
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Progranulin enhances neural progenitor cell proliferation through glycogen synthase kinase 3β phosphorylation.
Nedachi T, Kawai T, Matsuwaki T, Yamanouchi K, Nishihara M
Neuroscience. 2011
PubMed ID: 21540081
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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Making and breaking peptide bonds: protein engineering using sortase.
Popp MW, Ploegh HL
Angew Chem Int Ed Engl. 2011
PubMed ID: 21538739
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Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, Farese RV, Posner BA, Yu G, Herz J
J Biol Chem. 2011
PubMed ID: 21454553
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Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels.
Cruchaga C, Graff C, Chiang HH, Wang J, Hinrichs AL, Spiegel N, Bertelsen S, Mayo K, Norton JB, Morris JC, Goate A
Arch Neurol. 2011
PubMed ID: 21220649
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Expression pattern of progranulin in the human placenta and its effect on cell proliferation in the choriocarcinoma cell line BeWo.
Stubert J, Richter DU, Gerber B, Briese V
J Reprod Dev. 2011
PubMed ID: 21123963
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Granulin is a soluble cofactor for toll-like receptor 9 signaling.
Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann MM, Nishihara M, Ploegh HL
Immunity. 2011
PubMed ID: 21497117
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The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.
Tang W, Lu Y, Tian QY, Zhang Y, Guo FJ, Liu GY, Syed NM, Lai Y, Lin EA, Kong L, Su J, Yin F, Ding AH, Zanin-Zhorov A, Dustin ML, Tao J, Craft J, Yin Z, Feng JQ, Abramson SB, Yu XP, Liu CJ
Science. 2011
PubMed ID: 21393509
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Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration.
Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, Gearing M, Beach TG, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Pickering-Brown SM, Snowden J, van Swieten JC, Heutink P, Seelaar H, Murrell JR, Ghetti B, Spina S, Grafman J, Kaye JA, Woltjer RL, Mesulam M, Bigio E, Lladó A, Miller BL, Alzualde A, Moreno F, Rohrer JD, Mackenzie IR, Feldman HH, Hamilton RL, Cruts M, Engelborghs S, De Deyn PP, Van Broeckhoven C, Bird TD, Cairns NJ, Goate A, Frosch MP, Riederer PF, Bogdanovic N, Lee VM, Trojanowski JQ, Van Deerlin VM
Arch Neurol. 2011
PubMed ID: 21482928
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Novel progranulin mutation detected in 2 patients with FTLD.
Skoglund L, Matsui T, Freeman SH, Wallin A, Blom ES, Frosch MP, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A
Alzheimer Dis Assoc Disord. 2011
PubMed ID: 20975516
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No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration.
Rollinson S, Rohrer JD, van der Zee J, Sleegers K, Mead S, Engelborghs S, Collinge J, De Deyn PP, Mann DM, Van Broeckhoven C, Pickering-Brown SM
Neurobiol Aging. 2011
PubMed ID: 19446372
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A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.
Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21368173
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Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration.
Borroni B, Bonvicini C, Galimberti D, Tremolizzo L, Papetti A, Archetti S, Turla M, Alberici A, Agosti C, Premi E, Appollonio I, Rainero I, Ferrarese C, Gennarelli M, Scarpini E, Padovani A
Neurobiol Aging. 2011
PubMed ID: 20947212
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Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, Cruts M, Herms J, Van Broeckhoven C, Haass C
J Neurosci. 2011
PubMed ID: 21289198
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TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers.
Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, Gonzalez J, Seeley WW, Johnson N, Beach TG, Mesulam M, Forloni G, Kertesz A, Knopman DS, Uitti R, White CL, Caselli R, Lippa C, Bigio EH, Wszolek ZK, Binetti G, Mackenzie IR, Miller BL, Boeve BF, Younkin SG, Dickson DW, Petersen RC, Graff-Radford NR, Geschwind DH, Rademakers R
Neurology. 2011
PubMed ID: 21178100
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Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Kahle JJ, Gulbahce N, Shaw CA, Lim J, Hill DE, Barabási AL, Zoghbi HY
Hum Mol Genet. 2011
PubMed ID: 21078624
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Serum progranulin as an independent marker of liver fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease.
Yilmaz Y, Eren F, Yonal O, Polat Z, Bacha M, Kurt R, Ozturk O, Avsar E
Dis Markers. 2011
PubMed ID: 22045426
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Progranulin, a glycoprotein deficient in frontotemporal dementia, is a novel substrate of several protein disulfide isomerase family proteins.
Almeida S, Zhou L, Gao FB
PLoS One. 2011
PubMed ID: 22028881
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Low plasma progranulin levels in children with autism.
Al-Ayadhi LY, Mostafa GA
J Neuroinflammation. 2011
PubMed ID: 21892962
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Variability of the clinical phenotype in an Italian family with dementia associated with an intronic deletion in the GRN gene.
Marcon G, Rossi G, Giaccone G, Giovagnoli AR, Piccoli E, Zanini S, Geatti O, Toso V, Grisoli M, Tagliavini F
J Alzheimers Dis. 2011
PubMed ID: 21677378
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Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients.
Bossù P, Salani F, Alberici A, Archetti S, Bellelli G, Galimberti D, Scarpini E, Spalletta G, Caltagirone C, Padovani A, Borroni B
J Neuroinflammation. 2011
PubMed ID: 21645364
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Phenotypic heterogeneity of the GRN Asp22fs mutation in a large Italian kindred.
Pietroboni AM, Fumagalli GG, Ghezzi L, Fenoglio C, Cortini F, Serpente M, Cantoni C, Rotondo E, Corti P, Carecchio M, Bassi M, Bresolin N, Galbiati D, Galimberti D, Scarpini E
J Alzheimers Dis. 2011
PubMed ID: 21258152
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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity.
Pickford F, Marcus J, Camargo LM, Xiao Q, Graham D, Mo JR, Burkhardt M, Kulkarni V, Crispino J, Hering H, Hutton M
Am J Pathol. 2011
PubMed ID: 21224065
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rs5848 variant of progranulin gene is a risk of Alzheimer's disease in the Taiwanese population.
Lee MJ, Chen TF, Cheng TW, Chiu MJ
Neurodegener Dis. 2011
PubMed ID: 21212639
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Age-dependent changes in progranulin expression in the mouse brain.
Matsuwaki T, Asakura R, Suzuki M, Yamanouchi K, Nishihara M
J Reprod Dev. 2011
PubMed ID: 20962456
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A novel progranulin mutation causing frontotemporal lobar degeneration with heterogeneous phenotypic expression.
Rossi G, Piccoli E, Benussi L, Caso F, Redaelli V, Magnani G, Binetti G, Ghidoni R, Perani D, Giaccone G, Tagliavini F
J Alzheimers Dis. 2011
PubMed ID: 20930271
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Granulin-epithelin precursor and ATP-dependent binding cassette (ABC)B5 regulate liver cancer cell chemoresistance.
Cheung ST, Cheung PF, Cheng CK, Wong NC, Fan ST
Gastroenterology. 2011
PubMed ID: 20682318
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Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma.
Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, Dejesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, Petersen RC, Graff-Radford NR, Younkin SG, Rademakers R
Am J Hum Genet. 2010
PubMed ID: 21087763
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Microglial upregulation of progranulin as a marker of motor neuron degeneration.
Philips T, De Muynck L, Thu HN, Weynants B, Vanacker P, Dhondt J, Sleegers K, Schelhaas HJ, Verbeek M, Vandenberghe R, Sciot R, Van Broeckhoven C, Lambrechts D, Van Leuven F, Van Den Bosch L, Robberecht W, Van Damme P
J Neuropathol Exp Neurol. 2010
PubMed ID: 21107132
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Hypoxia induces up-regulation of progranulin in neuroblastoma cell lines.
Piscopo P, Rivabene R, Adduci A, Mallozzi C, Malvezzi-Campeggi L, Crestini A, Confaloni A
Neurochem Int. 2010
PubMed ID: 20933034
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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia.
Yin F, Dumont M, Banerjee R, Ma Y, Li H, Lin MT, Beal MF, Nathan C, Thomas B, Ding A
FASEB J. 2010
PubMed ID: 20667979
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Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.
Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM
Neuron. 2010
PubMed ID: 21092856
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Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group.
Wang WX, Kyprianou N, Wang X, Nelson PT
Cancer Res. 2010
PubMed ID: 20884628
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Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations.
Rohrer JD, Ridgway GR, Modat M, Ourselin S, Mead S, Fox NC, Rossor MN, Warren JD
Neuroimage. 2010
PubMed ID: 20045477
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rs5848 polymorphism and serum progranulin level.
Hsiung GY, Fok A, Feldman HH, Rademakers R, Mackenzie IR
J Neurol Sci. 2010
PubMed ID: 21047645
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Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures.
Kleinberger G, Wils H, Ponsaerts P, Joris G, Timmermans JP, Van Broeckhoven C, Kumar-Singh S
J Neurochem. 2010
PubMed ID: 20731760
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Progranulin expression in the developing and adult murine brain.
Petkau TL, Neal SJ, Orban PC, MacDonald JL, Hill AM, Lu G, Feldman HH, Mackenzie IR, Leavitt BR
J Comp Neurol. 2010
PubMed ID: 20737593
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Prion Protein Codon 129 Polymorphism Modifies Age at Onset of Frontotemporal Dementia With the C.709-1G>A Progranulin Mutation.
Moreno F, Alzualde A, Camblor PM, Barandiaran M, Van Deerlin VM, Gabilondo A, Martí Massó JF, de Munain AL, Indakoetxea B
Alzheimer Dis Assoc Disord. 2010
PubMed ID: 20711061
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Familial frontotemporal dementia with parkinsonism associated with the progranulin c.C1021T (p.Q341X) mutation.
Di Fabio R, Tessa A, Simons EJ, Santorelli FM, Casali C, Serrao M, Pierelli F, Bonifati V
Parkinsonism Relat Disord. 2010
PubMed ID: 20570546
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Progranulin mutations are a common cause of FTLD in Northern Italy.
Benussi L, Ghidoni R, Binetti G
Alzheimer Dis Assoc Disord. 2010
PubMed ID: 20798611
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Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging.
Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J
Am J Pathol. 2010
PubMed ID: 20522652
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miR-107 regulates granulin/progranulin with implications for traumatic brain injury and neurodegenerative disease.
Wang WX, Wilfred BR, Madathil SK, Tang G, Hu Y, Dimayuga J, Stromberg AJ, Huang Q, Saatman KE, Nelson PT
Am J Pathol. 2010
PubMed ID: 20489155
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HDL/apolipoprotein A-I binds to macrophage-derived progranulin and suppresses its conversion into proinflammatory granulins.
Okura H, Yamashita S, Ohama T, Saga A, Yamamoto-Kakuta A, Hamada Y, Sougawa N, Ohyama R, Sawa Y, Matsuyama A
J Atheroscler Thromb. 2010
PubMed ID: 20215705
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Progranulin promotes neurite outgrowth and neuronal differentiation by regulating GSK-3β.
Gao X, Joselin AP, Wang L, Kar A, Ray P, Bateman A, Goate AM, Wu JY
Protein Cell. 2010
PubMed ID: 21204008
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Progranulin (GRN) in two siblings of a Latino family and in other patients with schizophrenia.
Momeni P, DeTucci K, Straub RE, Weinberger DR, Davies P, Grafman J, Hardy J, Huey ED
Neurocase. 2010
PubMed ID: 20087814
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Expression of progranulin (Acrogranin/PCDGF/Granulin-Epithelin Precursor) in benign and malignant ovarian tumors and activation of MAPK signaling in ovarian cancer cell line.
Cuevas-Antonio R, Cancino C, Arechavaleta-Velasco F, Andrade A, Barron L, Estrada I, Fernandez RL, Olguin V, Ruiz S, Imani F, Zeferino-Toquero M, Ulloa-Aguirre A, Gerton GL, Diaz-Cueto L
Cancer Invest. 2010
PubMed ID: 19863344
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Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males.
Fenoglio C, Scalabrini D, Esposito F, Comi C, Cavalla P, De Riz M, Martinelli V, Piccio LM, Venturelli E, Fumagalli G, Capra R, Collimedaglia L, Ghezzi A, Rodegher ME, Vercellino M, Leone M, Giordana MT, Bresolin N, Monaco F, Comi G, Scarpini E, Martinelli-Boneschi F, Galimberti D
Genes Immun. 2010
PubMed ID: 20463744
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Screening for MAPT and PGRN mutations in Korean patients with PSP/CBS/FTD.
Kim HJ, Jeon BS, Yun JY, Seong MW, Park SS, Lee JY
Parkinsonism Relat Disord. 2010
PubMed ID: 20171924
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New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M
Genes Immun. 2010
PubMed ID: 20237496
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Progranulin (granulin/epithelin precursor) and its constituent granulin repeats repress transcription from cellular promoters.
Hoque M, Mathews MB, Pe'ery T
J Cell Physiol. 2010
PubMed ID: 20054825
-
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions.
Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, van Swieten JC, Murrell JR, Ghetti B, Spina S, Grafman J, Hodges J, Spillantini MG, Gilman S, Lieberman AP, Kaye JA, Woltjer RL, Bigio EH, Mesulam M, Al-Sarraj S, Troakes C, Rosenberg RN, White CL, Ferrer I, Lladó A, Neumann M, Kretzschmar HA, Hulette CM, Welsh-Bohmer KA, Miller BL, Alzualde A, de Munain AL, McKee AC, Gearing M, Levey AI, Lah JJ, Hardy J, Rohrer JD, Lashley T, Mackenzie IR, Feldman HH, Hamilton RL, Dekosky ST, van der Zee J, Kumar-Singh S, Van Broeckhoven C, Mayeux R, Vonsattel JP, Troncoso JC, Kril JJ, Kwok JB, Halliday GM, Bird TD, Ince PG, Shaw PJ, Cairns NJ, Morris JC, McLean CA, DeCarli C, Ellis WG, Freeman SH, Frosch MP, Growdon JH, Perl DP, Sano M, Bennett DA, Schneider JA, Beach TG, Reiman EM, Woodruff BK, Cummings J, Vinters HV, Miller CA, Chui HC, Alafuzoff I, Hartikainen P, Seilhean D, Galasko D, Masliah E, Cotman CW, Tuñón MT, Martínez MC, Munoz DG, Carroll SL, Marson D, Riederer PF, Bogdanovic N, Schellenberg GD, Hakonarson H, Trojanowski JQ, Lee VM
Nat Genet. 2010
PubMed ID: 20154673
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Pathogenic cysteine mutations affect progranulin function and production of mature granulins.
Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martínez M, Wang L, Wu JY, Robberecht W, Goate A
J Neurochem. 2010
PubMed ID: 20028451
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Role of progranulin as a biomarker for Alzheimer's disease.
Sleegers K, Brouwers N, Van Broeckhoven C
Biomark Med. 2010
PubMed ID: 20387302
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Alzheimer disease-like phenotype associated with the c.154delA mutation in progranulin.
Kelley BJ, Haidar W, Boeve BF, Baker M, Shiung M, Knopman DS, Rademakers R, Hutton M, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Petersen RC
Arch Neurol. 2010
PubMed ID: 20142525
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The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration.
Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, Danek A, Galasko DR, Arnold SE, Chen-Plotkin A, Karydas A, Miller BL, Trojanowski JQ, Lee VM, Schellenberg GD, Van Deerlin VM
Arch Neurol. 2010
PubMed ID: 20142524
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A thorough assessment of benign genetic variability in GRN and MAPT.
Guerreiro RJ, Washecka N, Hardy J, Singleton A
Hum Mutat. 2010
PubMed ID: 20020531
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Cerebrospinal fluid progranulin levels in patients with different multiple sclerosis subtypes.
De Riz M, Galimberti D, Fenoglio C, Piccio LM, Scalabrini D, Venturelli E, Pietroboni A, Piola M, Naismith RT, Parks BJ, Fumagalli G, Bresolin N, Cross AH, Scarpini E
Neurosci Lett. 2010
PubMed ID: 19963041
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Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice.
Yin F, Banerjee R, Thomas B, Zhou P, Qian L, Jia T, Ma X, Ma Y, Iadecola C, Beal MF, Nathan C, Ding A
J Exp Med. 2010
PubMed ID: 20026663
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Evaluation of urinary proepithelin as a potential biomarker for bladder cancer detection and prognosis in Egyptian patients.
Selmy MA, Ibrahim GH, El Serafi TI, Ghobeish AA
Cancer Biomark. 2010
PubMed ID: 21263192
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GEP, a local growth factor, is critical for odontogenesis and amelogenesis.
Cao Z, Jiang B, Xie Y, Liu CJ, Feng JQ
Int J Biol Sci. 2010
PubMed ID: 21152114
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Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes.
Tönjes A, Fasshauer M, Kratzsch J, Stumvoll M, Blüher M
PLoS One. 2010
PubMed ID: 21085476
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Intra-familial clinical heterogeneity due to FTLD-U with TDP-43 proteinopathy caused by a novel deletion in progranulin gene (PGRN).
Gabryelewicz T, Masellis M, Berdynski M, Bilbao JM, Rogaeva E, St George-Hyslop P, Barczak A, Czyzewski K, Barcikowska M, Wszolek Z, Black SE, Zekanowski C
J Alzheimers Dis. 2010
PubMed ID: 20930269
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Low serum progranulin predicts the presence of mutations: a prospective study.
Schofield EC, Halliday GM, Kwok J, Loy C, Double KL, Hodges JR
J Alzheimers Dis. 2010
PubMed ID: 20858962
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MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia.
Jiao J, Herl LD, Farese RV, Gao FB
PLoS One. 2010
PubMed ID: 20479936
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Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.
Dickson DW, Baker M, Rademakers R
Neurodegener Dis. 2010
PubMed ID: 20197700
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GRN variability contributes to sporadic frontotemporal lobar degeneration.
Galimberti D, Fenoglio C, Cortini F, Serpente M, Venturelli E, Villa C, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Scalabrini D, Restelli I, Boneschi FM, Cappa S, Binetti G, Mariani C, Rainero I, Giordana MT, Bresolin N, Scarpini E
J Alzheimers Dis. 2010
PubMed ID: 20061636
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Progranulin expression is upregulated after spinal contusion in mice.
Naphade SB, Kigerl KA, Jakeman LB, Kostyk SK, Popovich PG, Kuret J
Acta Neuropathol. 2010
PubMed ID: 19946692
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[Clinical, pathological, and genetic characteristics of frontotemporal dementia and parkinsonism linked to chromosome 17 with mutations in the MAPT and PGRN]
Tsuboi Y
Brain Nerve. 2009
PubMed ID: 19938685
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Corticobasal syndrome associated with a novel 1048_1049insG progranulin mutation.
Rohrer JD, Beck J, Warren JD, King A, Al Sarraj S, Holton J, Revesz T, Collinge J, Mead S
J Neurol Neurosurg Psychiatry. 2009
PubMed ID: 19864668
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The granulin gene family: from cancer to dementia.
Bateman A, Bennett HP
Bioessays. 2009
PubMed ID: 19795409
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Novel PSEN1 and PGRN mutations in early-onset familial frontotemporal dementia.
Bernardi L, Tomaino C, Anfossi M, Gallo M, Geracitano S, Costanzo A, Colao R, Puccio G, Frangipane F, Curcio SA, Mirabelli M, Smirne N, Iapaolo D, Maletta RG, Bruni AC
Neurobiol Aging. 2009
PubMed ID: 18314228
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"Frontotemporoparietal" dementia: clinical phenotype associated with the c.709-1G>A PGRN mutation.
Moreno F, Indakoetxea B, Barandiaran M, Alzualde A, Gabilondo A, Estanga A, Ruiz J, Ruibal M, Bergareche A, Martí-Massó JF, López de Munain A
Neurology. 2009
PubMed ID: 19858458
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Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models.
Pereson S, Wils H, Kleinberger G, McGowan E, Vandewoestyne M, Van Broeck B, Joris G, Cuijt I, Deforce D, Hutton M, Van Broeckhoven C, Kumar-Singh S
J Pathol. 2009
PubMed ID: 19557827
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Alteration in anxiety with relation to the volume of the locus ceruleus in progranulin-deficient mice.
Chiba S, Matsuwaki T, Yamanouchi K, Nishihara M
J Reprod Dev. 2009
PubMed ID: 19550107
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Progranulin expression in advanced human atherosclerotic plaque.
Kojima Y, Ono K, Inoue K, Takagi Y, Kikuta K, Nishimura M, Yoshida Y, Nakashima Y, Matsumae H, Furukawa Y, Mikuni N, Nobuyoshi M, Kimura T, Kita T, Tanaka M
Atherosclerosis. 2009
PubMed ID: 19321167
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Brain progranulin expression in GRN-associated frontotemporal lobar degeneration.
Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, Unger T, Wood EM, Van Deerlin VM, Trojanowski JQ, Lee VM
Acta Neuropathol. 2009
PubMed ID: 19649643
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ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.
Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg HM, Yu XP, Liu CJ
Mol Cell Biol. 2009
PubMed ID: 19487464
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GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.
Jasinska-Myga B, Wider C, Opala G, Krygowska-Wajs A, Barcikowska M, Czyzewski K, Baker M, Rademakers R, Uitti RJ, Farrer MJ, Ross OA, Wszolek ZK
Eur J Neurol. 2009
PubMed ID: 19473366
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Cortical atrophy and language network reorganization associated with a novel progranulin mutation.
Cruchaga C, Fernández-Seara MA, Seijo-Martínez M, Samaranch L, Lorenzo E, Hinrichs A, Irigoyen J, Maestro C, Prieto E, Martí-Climent JM, Arbizu J, Pastor MA, Pastor P
Cereb Cortex. 2009
PubMed ID: 19020205
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No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort.
Del Bo R, Corti S, Santoro D, Ghione I, Fenoglio C, Ghezzi S, Ranieri M, Galimberti D, Mancuso M, Siciliano G, Briani C, Murri L, Scarpini E, Schymick JC, Traynor BJ, Bresolin N, Comi GP
Neurobiol Aging. 2009
PubMed ID: 19632744
-
Rs5848 Variant Influences GRN mRNA Levels in Brain and Peripheral Mononuclear Cells in Patients with Alzheimer's Disease.
Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K, Piccio LM, Clerici F, Albani D, Mariani C, Forloni G, Bresolin N, Goate AM, Scarpini E
J Alzheimers Dis. 2009
PubMed ID: 19625741
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Frequency of progranulin mutations in a German cohort of 79 frontotemporal dementia patients.
Schlachetzki JC, Schmidtke K, Beckervordersandforth J, Borozdin W, Wilhelm C, Hüll M, Kohlhase J
J Neurol. 2009
PubMed ID: 19618231
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Higher than expected progranulin mutation rate in a case series of Italian FTLD patients.
Tremolizzo L, Gelosa G, Galbussera A, Isella V, Arosio C, Bertola F, Casati G, Piperno A, Ferrarese C, Appollonio I
Alzheimer Dis Assoc Disord. 2009
PubMed ID: 19730171
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PGRN mutations in northern Italy.
Borroni B, Alberici A, Padovani A
Alzheimer Dis Assoc Disord. 2009
PubMed ID: 19730170
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y
Proteomics. 2009
PubMed ID: 19343720
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Proepithelin is an autocrine growth factor for bladder cancer.
Lovat F, Bitto A, Xu SQ, Fassan M, Goldoni S, Metalli D, Wubah V, McCue P, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A
Carcinogenesis. 2009
PubMed ID: 19237611
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Pallidonigral TDP-43 pathology in Perry syndrome.
Wider C, Dickson DW, Stoessl AJ, Tsuboi Y, Chapon F, Gutmann L, Lechevalier B, Calne DB, Personett DA, Hulihan M, Kachergus J, Rademakers R, Baker MC, Grantier LL, Sujith OK, Brown L, Calne S, Farrer MJ, Wszolek ZK
Parkinsonism Relat Disord. 2009
PubMed ID: 18723384
-
Prominent phenotypic variability associated with mutations in Progranulin.
Kelley BJ, Haidar W, Boeve BF, Baker M, Graff-Radford NR, Krefft T, Frank AR, Jack CR, Shiung M, Knopman DS, Josephs KA, Parashos SA, Rademakers R, Hutton M, Pickering-Brown S, Adamson J, Kuntz KM, Dickson DW, Parisi JE, Smith GE, Ivnik RJ, Petersen RC
Neurobiol Aging. 2009
PubMed ID: 17949857
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Parkinsonism and impulse control disorder: presentation of a new progranulin gene mutation.
Wong SH, Lecky BR, Steiger MJ
Mov Disord. 2009
PubMed ID: 19133655
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Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN.
Whitwell JL, Jack CR, Boeve BF, Senjem ML, Baker M, Rademakers R, Ivnik RJ, Knopman DS, Wszolek ZK, Petersen RC, Josephs KA
Neurology. 2009
PubMed ID: 19255408
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Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth.
Monami G, Emiliozzi V, Bitto A, Lovat F, Xu SQ, Goldoni S, Fassan M, Serrero G, Gomella LG, Baffa R, Iozzo RV, Morrione A
Am J Pathol. 2009
PubMed ID: 19179604
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Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwide.
Benussi L, Ghidoni R, Pegoiani E, Moretti DV, Zanetti O, Binetti G
Neurobiol Dis. 2009
PubMed ID: 19101631
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Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth.
Kato M, Hasunuma N, Nakayama R, Takeda J, Itami S, Taira M, Manabe M, Osada S
J Dermatol Sci. 2009
PubMed ID: 19091514
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Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue.
Youn BS, Bang SI, Klöting N, Park JW, Lee N, Oh JE, Pi KB, Lee TH, Ruschke K, Fasshauer M, Stumvoll M, Blüher M
Diabetes. 2009
PubMed ID: 19056610
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Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H
J Proteome Res. 2009
PubMed ID: 19159218
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Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation.
Skoglund L, Brundin R, Olofsson T, Kalimo H, Ingvast S, Blom ES, Giedraitis V, Ingelsson M, Lannfelt L, Basun H, Glaser A
Neurogenetics. 2009
PubMed ID: 18855025
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Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members.
Finch N, Baker M, Crook R, Swanson K, Kuntz K, Surtees R, Bisceglio G, Rovelet-Lecrux A, Boeve B, Petersen RC, Dickson DW, Younkin SG, Deramecourt V, Crook J, Graff-Radford NR, Rademakers R
Brain. 2009
PubMed ID: 19158106
-
Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury.
Moisse K, Volkening K, Leystra-Lantz C, Welch I, Hill T, Strong MJ
Brain Res. 2009
PubMed ID: 19046946
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Progranulin (PGRN) expression in ALS: an immunohistochemical study.
Irwin D, Lippa CF, Rosso A
J Neurol Sci. 2009
PubMed ID: 18848708
-
No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration.
Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A
Dement Geriatr Cogn Disord. 2009
PubMed ID: 19940479
-
Progranulin is expressed within motor neurons and promotes neuronal cell survival.
Ryan CL, Baranowski DC, Chitramuthu BP, Malik S, Li Z, Cao M, Minotti S, Durham HD, Kay DG, Shaw CA, Bennett HP, Bateman A
BMC Neurosci. 2009
PubMed ID: 19860916
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Variation at GRN 3'-UTR rs5848 is not associated with a risk of frontotemporal lobar degeneration in Dutch population.
Simón-Sánchez J, Seelaar H, Bochdanovits Z, Deeg DJ, van Swieten JC, Heutink P
PLoS One. 2009
PubMed ID: 19847305
-
Low prevalence of progranulin mutations in Finnish patients with frontotemporal lobar degeneration.
Krüger J, Kaivorinne AL, Udd B, Majamaa K, Remes AM
Eur J Neurol. 2009
PubMed ID: 19049508
-
Granulin mutations associated with frontotemporal lobar degeneration and related disorders: an update.
Gijselinck I, Van Broeckhoven C, Cruts M
Hum Mutat. 2008
PubMed ID: 18543312
-
An association study between granulin gene polymorphisms and Alzheimer's disease in Finnish population.
Viswanathan J, Mäkinen P, Helisalmi S, Haapasalo A, Soininen H, Hiltunen M
Am J Med Genet B Neuropsychiatr Genet. 2008
PubMed ID: 19016491
-
Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family.
Chiang HH, Rosvall L, Brohede J, Axelman K, Björk BF, Nennesmo I, Robins T, Graff C
Alzheimers Dement. 2008
PubMed ID: 19012866
-
Progranulin variability has no major role in Parkinson disease genetic etiology.
Nuytemans K, Pals P, Sleegers K, Engelborghs S, Corsmit E, Peeters K, Pickut B, Mattheijssens M, Cras P, De Deyn PP, Theuns J, Broeckhoven CV
Neurology. 2008
PubMed ID: 18838661
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Association between progranulin and beta-amyloid in dementia with Lewy bodies.
Revuelta GJ, Rosso A, Lippa CF
Am J Alzheimers Dis Other Demen. 2008
PubMed ID: 18955727
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Mutations in progranulin (GRN) within the spectrum of clinical and pathological phenotypes of frontotemporal dementia.
van Swieten JC, Heutink P
Lancet Neurol. 2008
PubMed ID: 18771956
-
Novel exon 1 progranulin gene variant in Alzheimer's disease.
Cortini F, Fenoglio C, Guidi I, Venturelli E, Pomati S, Marcone A, Scalabrini D, Villa C, Clerici F, Dalla Valle E, Mariani C, Cappa S, Bresolin N, Scarpini E, Galimberti D
Eur J Neurol. 2008
PubMed ID: 18752597
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Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration.
Ghidoni R, Benussi L, Glionna M, Franzoni M, Binetti G
Neurology. 2008
PubMed ID: 18768919
-
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia.
Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW
Hum Mol Genet. 2008
PubMed ID: 18723524
-
Novel progranulin mutation: screening for PGRN mutations in a Portuguese series of FTD/CBS cases.
Guerreiro RJ, Santana I, Bras JM, Revesz T, Rebelo O, Ribeiro MH, Santiago B, Oliveira CR, Singleton A, Hardy J
Mov Disord. 2008
PubMed ID: 18464284
-
Gene expression study on peripheral blood identifies progranulin mutations.
Coppola G, Karydas A, Rademakers R, Wang Q, Baker M, Hutton M, Miller BL, Geschwind DH
Ann Neurol. 2008
PubMed ID: 18551524
-
Deletion of the progranulin gene in patients with frontotemporal lobar degeneration or Parkinson disease.
Rovelet-Lecrux A, Deramecourt V, Legallic S, Maurage CA, Le Ber I, Brice A, Lambert JC, Frébourg T, Hannequin D, Pasquier F, Campion D
Neurobiol Dis. 2008
PubMed ID: 18479928
-
Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease.
Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, Van Broeckhoven C
Neurology. 2008
PubMed ID: 18565828
-
Progranulin gene mutation with an unusual clinical and neuropathologic presentation.
Wider C, Uitti RJ, Wszolek ZK, Fang JY, Josephs KA, Baker MC, Rademakers R, Hutton ML, Dickson DW
Mov Disord. 2008
PubMed ID: 18442119
-
Brain magnetic resonance imaging structural changes in a pedigree of asymptomatic progranulin mutation carriers.
Borroni B, Alberici A, Premi E, Archetti S, Garibotto V, Agosti C, Gasparotti R, Di Luca M, Perani D, Padovani A
Rejuvenation Res. 2008
PubMed ID: 18593276
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Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance.
Chen XY, Li JS, Liang QP, He DZ, Zhao J
Chin Med J (Engl). 2008
PubMed ID: 18706200
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Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration.
Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM
Hum Mol Genet. 2008
PubMed ID: 18223198
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Mutations in progranulin gene: clinical, pathological, and ribonucleic acid expression findings.
López de Munain A, Alzualde A, Gorostidi A, Otaegui D, Ruiz-Martínez J, Indakoetxea B, Ferrer I, Pérez-Tur J, Sáenz A, Bergareche A, Barandiarán M, Poza JJ, Zabalza R, Ruiz I, Urtasun M, Fernández-Manchola I, Olasagasti B, Espinal JB, Olaskoaga J, Ruibal M, Moreno F, Carrera N, Massó JF
Biol Psychiatry. 2008
PubMed ID: 17950702
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E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.
Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F
Cell Signal. 2008
PubMed ID: 18276110
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Progranulin genetic variations in frontotemporal lobar degeneration: evidence for low mutation frequency in an Italian clinical series.
Borroni B, Archetti S, Alberici A, Agosti C, Gennarelli M, Bigni B, Bonvicini C, Ferrari M, Bellelli G, Galimberti D, Scarpini E, Di Lorenzo D, Caimi L, Caltagirone C, Di Luca M, Padovani A
Neurogenetics. 2008
PubMed ID: 18392865
-
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, Carmeliet P, Van Den Bosch L, Robberecht W
J Cell Biol. 2008
PubMed ID: 18378771
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Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene.
Rohrer JD, Warren JD, Omar R, Mead S, Beck J, Revesz T, Holton J, Stevens JM, Al-Sarraj S, Pickering-Brown SM, Hardy J, Fox NC, Collinge J, Warrington EK, Rossor MN
Arch Neurol. 2008
PubMed ID: 18413474
-
Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN).
Boeve BF, Hutton M
Arch Neurol. 2008
PubMed ID: 18413467
-
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities.
Tolkatchev D, Malik S, Vinogradova A, Wang P, Chen Z, Xu P, Bennett HP, Bateman A, Ni F
Protein Sci. 2008
PubMed ID: 18359860
-
Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A
Hum Mutat. 2008
PubMed ID: 18183624
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Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study.
Le Ber I, Camuzat A, Hannequin D, Pasquier F, Guedj E, Rovelet-Lecrux A, Hahn-Barma V, van der Zee J, Clot F, Bakchine S, Puel M, Ghanim M, Lacomblez L, Mikol J, Deramecourt V, Lejeune P, de la Sayette V, Belliard S, Vercelletto M, Meyrignac C, Van Broeckhoven C, Lambert JC, Verpillat P, Campion D, Habert MO, Dubois B, Brice A, French research network on FTD/FTD-MND
Brain. 2008
PubMed ID: 18245784
-
A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series.
Beck J, Rohrer JD, Campbell T, Isaacs A, Morrison KE, Goodall EF, Warrington EK, Stevens J, Revesz T, Holton J, Al-Sarraj S, King A, Scahill R, Warren JD, Fox NC, Rossor MN, Collinge J, Mead S
Brain. 2008
PubMed ID: 18234697
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Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations.
Pickering-Brown SM, Rollinson S, Du Plessis D, Morrison KE, Varma A, Richardson AM, Neary D, Snowden JS, Mann DM
Brain. 2008
PubMed ID: 18192287
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Toward a confocal subcellular atlas of the human proteome.
Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H
Mol Cell Proteomics. 2008
PubMed ID: 18029348
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A novel deletion in progranulin gene is associated with FTDP-17 and CBS.
Benussi L, Binetti G, Sina E, Gigola L, Bettecken T, Meitinger T, Ghidoni R
Neurobiol Aging. 2008
PubMed ID: 17157414
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Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.
Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C
J Biol Chem. 2008
PubMed ID: 17984093
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Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C
Neurology. 2008
PubMed ID: 18184915
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Role of MAPT mutations and haplotype in frontotemporal lobar degeneration in Northern Finland.
Kaivorinne AL, Krüger J, Kuivaniemi K, Tuominen H, Moilanen V, Majamaa K, Remes AM
BMC Neurol. 2008
PubMed ID: 19091059
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In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
Ghetti B, Spina S, Murrell JR, Huey ED, Pietrini P, Sweeney B, Wassermann EM, Keohane C, Farlow MR, Grafman J
Neurodegener Dis. 2008
PubMed ID: 18322394
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Progranulin locus deletion in frontotemporal dementia.
Gijselinck I, van der Zee J, Engelborghs S, Goossens D, Peeters K, Mattheijssens M, Corsmit E, Del-Favero J, De Deyn PP, Van Broeckhoven C, Cruts M
Hum Mutat. 2008
PubMed ID: 18157829
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Alteration of behavioural phenotype in mice by targeted disruption of the progranulin gene.
Kayasuga Y, Chiba S, Suzuki M, Kikusui T, Matsuwaki T, Yamanouchi K, Kotaki H, Horai R, Iwakura Y, Nishihara M
Behav Brain Res. 2007
PubMed ID: 17764761
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New genes, new dilemmas: FTLD genetics and its implications for families.
Goldman JS, Adamson J, Karydas A, Miller BL, Hutton M
Am J Alzheimers Dis Other Demen. 2007
PubMed ID: 18166610
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Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative.
Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, Wood EM, Yu CE, Josephs K, Sorenson E, Womack KB, Weintraub S, Pickering-Brown SM, Schofield PR, Brooks WS, Van Deerlin VM, Snowden J, Clark CM, Kertesz A, Boylan K, Ghetti B, Neary D, Schellenberg GD, Beach TG, Mesulam M, Mann D, Grafman J, Mackenzie IR, Feldman H, Bird T, Petersen R, Knopman D, Boeve B, Geschwind DH, Miller B, Wszolek Z, Lippa C, Bigio EH, Dickson D, Graff-Radford N, Hutton M
Lancet Neurol. 2007
PubMed ID: 17826340
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Clinicopathologic correlation in PGRN mutations.
Davion S, Johnson N, Weintraub S, Mesulam MM, Engberg A, Mishra M, Baker M, Adamson J, Hutton M, Rademakers R, Bigio EH
Neurology. 2007
PubMed ID: 17522386
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Progranulin null mutations in both sporadic and familial frontotemporal dementia.
Le Ber I, van der Zee J, Hannequin D, Gijselinck I, Campion D, Puel M, Laquerrière A, De Pooter T, Camuzat A, Van den Broeck M, Dubois B, Sellal F, Lacomblez L, Vercelletto M, Thomas-Antérion C, Michel BF, Golfier V, Didic M, Salachas F, Duyckaerts C, Cruts M, Verpillat P, Van Broeckhoven C, Brice A, French Research Network on FTD/FTD-MND
Hum Mutat. 2007
PubMed ID: 17436289
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Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations.
Van Deerlin VM, Wood EM, Moore P, Yuan W, Forman MS, Clark CM, Neumann M, Kwong LK, Trojanowski JQ, Lee VM, Grossman M
Arch Neurol. 2007
PubMed ID: 17698705
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Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
Bruni AC, Momeni P, Bernardi L, Tomaino C, Frangipane F, Elder J, Kawarai T, Sato C, Pradella S, Wakutani Y, Anfossi M, Gallo M, Geracitano S, Costanzo A, Smirne N, Curcio SA, Mirabelli M, Puccio G, Colao R, Maletta RG, Kertesz A, St George-Hyslop P, Hardy J, Rogaeva E
Neurology. 2007
PubMed ID: 17620546
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Progranulin and frontotemporal lobar degeneration.
Pickering-Brown SM
Acta Neuropathol. 2007
PubMed ID: 17572900
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The neuropathology and clinical phenotype of FTD with progranulin mutations.
Mackenzie IR
Acta Neuropathol. 2007
PubMed ID: 17458552
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Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes.
Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, Hutton M, Gass J, Cannon A, Rademakers R, Singleton AB, Hardiman O, Rothstein J, Hardy J, Traynor BJ
J Neurol Neurosurg Psychiatry. 2007
PubMed ID: 17371905
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Prosurvival function of the granulin-epithelin precursor is important in tumor progression and chemoresponse.
Pizarro GO, Zhou XC, Koch A, Gharib M, Raval S, Bible K, Jones MB
Int J Cancer. 2007
PubMed ID: 17266030
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A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD
Brain. 2007
PubMed ID: 17439980
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Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.
Xu K, Zhang Y, Ilalov K, Carlson CS, Feng JQ, Di Cesare PE, Liu CJ
J Biol Chem. 2007
PubMed ID: 17307734
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Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
van der Zee J, Le Ber I, Maurer-Stroh S, Engelborghs S, Gijselinck I, Camuzat A, Brouwers N, Vandenberghe R, Sleegers K, Hannequin D, Dermaut B, Schymkowitz J, Campion D, Santens P, Martin JJ, Lacomblez L, De Pooter T, Peeters K, Mattheijssens M, Vercelletto M, Van den Broeck M, Cruts M, De Deyn PP, Rousseau F, Brice A, Van Broeckhoven C
Hum Mutat. 2007
PubMed ID: 17345602
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Involvement of granulin in estrogen-induced neurogenesis in the adult rat hippocampus.
Chiba S, Suzuki M, Yamanouchi K, Nishihara M
J Reprod Dev. 2007
PubMed ID: 17179653
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Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis.
Xiao S, Sato C, Kawarai T, Goodall EF, Pall HS, Zinman LH, Robertson J, Morrison K, Rogaeva E
Neurobiol Aging. 2007
PubMed ID: 17383054
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Clinicopathologic features of frontotemporal dementia with progranulin sequence variation.
Spina S, Murrell JR, Huey ED, Wassermann EM, Pietrini P, Baraibar MA, Barbeito AG, Troncoso JC, Vidal R, Ghetti B, Grafman J
Neurology. 2007
PubMed ID: 17202431
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Voxel-based morphometry in frontotemporal lobar degeneration with ubiquitin-positive inclusions with and without progranulin mutations.
Whitwell JL, Jack CR, Baker M, Rademakers R, Adamson J, Boeve BF, Knopman DS, Parisi JF, Petersen RC, Dickson DW, Hutton ML, Josephs KA
Arch Neurol. 2007
PubMed ID: 17353379
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Progranulin mutations in Dutch familial frontotemporal lobar degeneration.
Bronner IF, Rizzu P, Seelaar H, van Mil SE, Anar B, Azmani A, Kaat LD, Rosso S, Heutink P, van Swieten JC
Eur J Hum Genet. 2007
PubMed ID: 17228326
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Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Josephs KA, Ahmed Z, Katsuse O, Parisi JF, Boeve BF, Knopman DS, Petersen RC, Davies P, Duara R, Graff-Radford NR, Uitti RJ, Rademakers R, Adamson J, Baker M, Hutton ML, Dickson DW
J Neuropathol Exp Neurol. 2007
PubMed ID: 17278999
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Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression.
Miyanishi M, Mandai M, Matsumura N, Yamaguchi K, Hamanishi J, Higuchi T, Takakura K, Fujii S
Oncol Rep. 2007
PubMed ID: 17203169
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Late-onset frontotemporal dementia associated with a novel PGRN mutation.
Lladó A, Sánchez-Valle R, Reñé R, Ezquerra M, Rey MJ, Tolosa E, Ferrer I, Molinuevo JL
J Neural Transm. 2007
PubMed ID: 17417739
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Progranulin in frontotemporal lobar degeneration and neuroinflammation.
Ahmed Z, Mackenzie IR, Hutton ML, Dickson DW
J Neuroinflammation. 2007
PubMed ID: 17291356
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Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2.
Liu Y, Xi L, Liao G, Wang W, Tian X, Wang B, Chen G, Han Z, Wu M, Wang S, Zhou J, Xu G, Lu Y, Ma D
BMC Cancer. 2007
PubMed ID: 17261172
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Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families.
Mesulam M, Johnson N, Krefft TA, Gass JM, Cannon AD, Adamson JL, Bigio EH, Weintraub S, Dickson DW, Hutton ML, Graff-Radford NR
Arch Neurol. 2007
PubMed ID: 17210807
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Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, Wszolek Z, Gonzalez J, Beach TG, Bigio E, Johnson N, Weintraub S, Mesulam M, White CL, Woodruff B, Caselli R, Hsiung GY, Feldman H, Knopman D, Hutton M, Rademakers R
Hum Mol Genet. 2006
PubMed ID: 16950801
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HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin.
Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM
Ann Neurol. 2006
PubMed ID: 16983685
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Characteristics of frontotemporal dementia patients with a Progranulin mutation.
Huey ED, Grafman J, Wassermann EM, Pietrini P, Tierney MC, Ghetti B, Spina S, Baker M, Hutton M, Elder JW, Berger SL, Heflin KA, Hardy J, Momeni P
Ann Neurol. 2006
PubMed ID: 16983677
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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17.
Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, Dickson D, Berger Z, Eriksen J, Robinson T, Zehr C, Dickey CA, Crook R, McGowan E, Mann D, Boeve B, Feldman H, Hutton M
Nature. 2006
PubMed ID: 16862116
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Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
Cruts M, Gijselinck I, van der Zee J, Engelborghs S, Wils H, Pirici D, Rademakers R, Vandenberghe R, Dermaut B, Martin JJ, van Duijn C, Peeters K, Sciot R, Santens P, De Pooter T, Mattheijssens M, Van den Broeck M, Cuijt I, Vennekens K, De Deyn PP, Kumar-Singh S, Van Broeckhoven C
Nature. 2006
PubMed ID: 16862115
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PC cell-derived growth factor stimulates proliferation and confers Trastuzumab resistance to Her-2-overexpressing breast cancer cells.
Kim WE, Serrero G
Clin Cancer Res. 2006
PubMed ID: 16857791
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Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats.
Lee HC, Yamanouchi K, Nishihara M
J Reprod Dev. 2006
PubMed ID: 16493179
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A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY
Cell. 2006
PubMed ID: 16713569
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DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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Oncogenic property of acrogranin in human uterine leiomyosarcoma: direct evidence of genetic contribution in in vivo tumorigenesis.
Matsumura N, Mandai M, Miyanishi M, Fukuhara K, Baba T, Higuchi T, Kariya M, Takakura K, Fujii S
Clin Cancer Res. 2006
PubMed ID: 16533762
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Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD.
Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chiò A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor BJ
BMC Neurol. 2006
PubMed ID: 17166276
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Towards a proteome-scale map of the human protein-protein interaction network.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M
Nature. 2005
PubMed ID: 16189514
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Effects of progranulin on blastocyst hatching and subsequent adhesion and outgrowth in the mouse.
Qin J, Díaz-Cueto L, Schwarze JE, Takahashi Y, Imai M, Isuzugawa K, Yamamoto S, Chang KT, Gerton GL, Imakawa K
Biol Reprod. 2005
PubMed ID: 15901638
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Granulin and granulin repeats interact with the Tat.P-TEFb complex and inhibit Tat transactivation.
Hoque M, Tian B, Mathews MB, Pe'ery T
J Biol Chem. 2005
PubMed ID: 15653695
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
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Granulin-epithelin precursor overexpression promotes growth and invasion of hepatocellular carcinoma.
Cheung ST, Wong SY, Leung KL, Chen X, So S, Ng IO, Fan ST
Clin Cancer Res. 2004
PubMed ID: 15569995
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Functional proteomics mapping of a human signaling pathway.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM
Genome Res. 2004
PubMed ID: 15231748
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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PC cell-derived growth factor expression in prostatic intraepithelial neoplasia and prostatic adenocarcinoma.
Pan CX, Kinch MS, Kiener PA, Langermann S, Serrero G, Sun L, Corvera J, Sweeney CJ, Li L, Zhang S, Baldridge LA, Jones TD, Koch MO, Ulbright TM, Eble JN, Cheng L
Clin Cancer Res. 2004
PubMed ID: 14977833
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
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Expression of PC-cell-derived growth factor in benign and malignant human breast epithelium.
Serrero G, Ioffe OB
Hum Pathol. 2003
PubMed ID: 14652816
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A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth.
Gonzalez EM, Mongiat M, Slater SJ, Baffa R, Iozzo RV
J Biol Chem. 2003
PubMed ID: 12900424
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Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis.
Serrero G
Biochem Biophys Res Commun. 2003
PubMed ID: 12914763
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Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development.
Daniel R, Daniels E, He Z, Bateman A
Dev Dyn. 2003
PubMed ID: 12889069
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The growth factor granulin interacts with cyclin T1 and modulates P-TEFb-dependent transcription.
Hoque M, Young TM, Lee CG, Serrero G, Mathews MB, Pe'ery T
Mol Cell Biol. 2003
PubMed ID: 12588988
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The Tat protein of the caprine arthritis encephalitis virus interacts with the Notch2 EGF-like repeats and the epithelin/granulin precursor.
Shoham N, Cohen L, Gazit A, Yaniv A
Intervirology. 2003
PubMed ID: 12931033
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The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer.
Jones MB, Michener CM, Blanchette JO, Kuznetsov VA, Raffeld M, Serrero G, Emmert-Buck MR, Petricoin EF, Krizman DB, Liotta LA, Kohn EC
Clin Cancer Res. 2003
PubMed ID: 12538450
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.
Zhu J, Nathan C, Jin W, Sim D, Ashcroft GS, Wahl SM, Lacomis L, Erdjument-Bromage H, Tempst P, Wright CD, Ding A
Cell. 2002
PubMed ID: 12526812
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.
Lemon WJ, Bernert H, Sun H, Wang Y, You M
J Med Genet. 2002
PubMed ID: 12205107
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Overexpression of translocation-associated fusion genes of FGFRI, MYC, NPMI, and DEK, but absence of the translocations in acute myeloid leukemia. A microarray analysis.
Larramendy ML, Niini T, Elonen E, Nagy B, Ollila J, Vihinen M, Knuutila S
Haematologica. 2002
PubMed ID: 12031912
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The EGF-like homeotic protein dlk affects cell growth and interacts with growth-modulating molecules in the yeast two-hybrid system.
Baladrón V, Ruiz-Hidalgo MJ, Bonvini E, Gubina E, Notario V, Laborda J
Biochem Biophys Res Commun. 2002
PubMed ID: 11846389
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M phase-specific association of human topoisomerase IIIbeta with chromosomes.
Kobayashi M, Hanai R
Biochem Biophys Res Commun. 2001
PubMed ID: 11549288
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Large-scale screen for genes involved in gonad development.
Wertz K, Herrmann BG
Mech Dev. 2000
PubMed ID: 11044607
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Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase.
Sui D, Wilson JE
Arch Biochem Biophys. 2000
PubMed ID: 11068878
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Ko MS, Kitchen JR, Wang X, Threat TA, Wang X, Hasegawa A, Sun T, Grahovac MJ, Kargul GJ, Lim MK, Cui Y, Sano Y, Tanaka T, Liang Y, Mason S, Paonessa PD, Sauls AD, DePalma GE, Sharara R, Rowe LB, Eppig J, Morrell C, Doi H
Development. 2000
PubMed ID: 10725249
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Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A.
Tolkatchev D, Ng A, Vranken W, Ni F
Biochemistry. 2000
PubMed ID: 10715107
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Suppression of copulatory behavior by intracerebroventricular infusion of antisense oligodeoxynucleotide of granulin in neonatal male rats.
Suzuki M, Bannai M, Matsumuro M, Furuhata Y, Ikemura R, Kuranaga E, Kaneda Y, Nishihara M, Takahashi M
Physiol Behav. 2000
PubMed ID: 10764901
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Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption.
Liau LM, Lallone RL, Seitz RS, Buznikov A, Gregg JP, Kornblum HI, Nelson SF, Bronstein JM
Cancer Res. 2000
PubMed ID: 10728698
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Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor).
Díaz-Cueto L, Stein P, Jacobs A, Schultz RM, Gerton GL
Dev Biol. 2000
PubMed ID: 10625564
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The human platelet alphaIIb gene is not closely linked to its integrin partner beta3.
Thornton MA, Poncz M, Korostishevsky M, Yakobson E, Usher S, Seligsohn U, Peretz H
Blood. 1999
PubMed ID: 10477733
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Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo.
He Z, Bateman A
Cancer Res. 1999
PubMed ID: 10397269
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Epithelin/granulin growth factors: extracellular cofactors for HIV-1 and HIV-2 Tat proteins.
Trinh DP, Brown KM, Jeang KT
Biochem Biophys Res Commun. 1999
PubMed ID: 10079180
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The genomic organization of type I keratin genes in mice.
Sato H, Koide T, Sagai T, Ishiguro SI, Tamai M, Saitou N, Shiroishi T
Genomics. 1999
PubMed ID: 10087197
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor).
Zhang H, Serrero G
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9826678
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A new mutation Rim3 resembling Re(den) is mapped close to retinoic acid receptor alpha (Rara) gene on mouse chromosome 11.
Sato H, Koide T, Masuya H, Wakana S, Sagai T, Umezawa A, Ishiguro S, Tamai M, Shiroishi T, Tama M
Mamm Genome. 1998
PubMed ID: 9434940
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Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J, Beier DR
Genome Res. 1997
PubMed ID: 9371744
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Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S
Gene. 1997
PubMed ID: 9373149
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Large-scale concatenation cDNA sequencing.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA
Genome Res. 1997
PubMed ID: 9110174
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An MMTV integration site maps near the distal end of mouse chromosome 11.
Rajan L, Dudley JP
Mamm Genome. 1997
PubMed ID: 9096121
-
Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit.
Kohda K, Matsuda Y, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
PubMed ID: 9382924
-
PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes.
Kandil E, Kohda K, Ishibashi T, Tanaka K, Kasahara M
Immunogenetics. 1997
PubMed ID: 9218537
-
Structural and functional analysis of a promoter of the human granulin/epithelin gene.
Bhandari V, Daniel R, Lim PS, Bateman A
Biochem J. 1996
PubMed ID: 8912679
-
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Mapping of Grn, the gene encoding the granulin/epithelin precursor (acrogranin), to mouse chromosome 11.
Bucan M, Gatalica B, Baba T, Gerton GL
Mamm Genome. 1996
PubMed ID: 8703129
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A "double adaptor" method for improved shotgun library construction.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA
Anal Biochem. 1996
PubMed ID: 8619474
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Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
Maruyama K, Sugano S
Gene. 1994
PubMed ID: 8125298
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The complementary deoxyribonucleic acid sequence, tissue distribution, and cellular localization of the rat granulin precursor.
Bhandari V, Giaid A, Bateman A
Endocrinology. 1993
PubMed ID: 8243292
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Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line.
Zhou J, Gao G, Crabb JW, Serrero G
J Biol Chem. 1993
PubMed ID: 8496151
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Exon/intron organization of the gene encoding the mouse epithelin/granulin precursor (acrogranin).
Baba T, Nemoto H, Watanabe K, Arai Y, Gerton GL
FEBS Lett. 1993
PubMed ID: 8482392
-
Characterisation of UGP and its relationship with beta-core fragment.
Kardana A, Bagshawe KD, Coles B, Read D, Taylor M
Br J Cancer. 1993
PubMed ID: 8471426
-
Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells.
Baba T, Hoff HB, Nemoto H, Lee H, Orth J, Arai Y, Gerton GL
Mol Reprod Dev. 1993
PubMed ID: 8471244
-
Structure and chromosomal location of the human granulin gene.
Bhandari V, Bateman A
Biochem Biophys Res Commun. 1992
PubMed ID: 1417868
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The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
Plowman GD, Green JM, Neubauer MG, Buckley SD, McDonald VL, Todaro GJ, Shoyab M
J Biol Chem. 1992
PubMed ID: 1618805
-
Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains.
Bhandari V, Palfree RG, Bateman A
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1542665
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Granulins, a novel class of peptide from leukocytes.
Bateman A, Belcourt D, Bennett H, Lazure C, Solomon S
Biochem Biophys Res Commun. 1990
PubMed ID: 2268320
-
Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins.
Shoyab M, McDonald VL, Byles C, Todaro GJ, Plowman GD
Proc Natl Acad Sci U S A. 1990
PubMed ID: 2236009
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