GRB2

Summary Top Help

Gene Description:

growth factor receptor-bound protein 2; growth factor receptor bound protein 2

Synonyms:

NCKAP2, MST084, ASH, Grb2, Ash, EGFRBP-GRB2, MSTP084, AA408164, GRB2, Grb3-3

Orthologs:

Human GRB2 (protein-coding), Mouse Grb2 (protein-coding), Rat Grb2 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr17:73314157..73401790 (87.63 kb) View in Genome Browser

(Mouse) NCBIM37 - chr11:115505359..115569911 (64.55 kb) View in Genome Browser

(Rat) RGSC3.4 - chr10:105722014..105818649 (96.64 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for GRB2:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for GRB2:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: 24

Biocarta: 37

Activation of Src by Protein-tyrosine phosphatase alpha	Human	Mouse
Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	Human	Mouse
BCR Signaling Pathway	Human	Mouse
Bioactive Peptide Induced Signaling Pathway	Human	Mouse
Calcium Signaling by HBx of Hepatitis B virus	Human	Mouse
CBL mediated ligand-induced downregulation of EGF receptors	Human	Mouse
EGF Signaling Pathway	Human	Mouse
EPO Signaling Pathway	Human	Mouse
Erk1/Erk2 Mapk Signaling pathway	Human	Mouse
Fc Epsilon Receptor I Signaling in Mast Cells	Human	Mouse
Growth Hormone Signaling Pathway	Human	Mouse
IGF-1 Signaling Pathway	Human	Mouse
IL 2 signaling pathway	Human	Mouse
IL 3 signaling pathway	Human	Mouse
IL 4 signaling pathway	Human	Mouse
IL 6 signaling pathway	Human	Mouse
IL-2 Receptor Beta Chain in T cell Activation	Human	Mouse
Inhibition of Cellular Proliferation by Gleevec	Human	Mouse
Insulin Signaling Pathway	Human	Mouse
Integrin Signaling Pathway	Human	Mouse
Links between Pyk2 and Map Kinases	Human	Mouse
MAPKinase Signaling Pathway	Human	Mouse
Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	Human	Mouse
Nerve growth factor pathway (NGF)	Human	Mouse
p38 MAPK Signaling Pathway	Human	Mouse
PDGF Signaling Pathway	Human	Mouse
PTEN dependent cell cycle arrest and apoptosis	Human	Mouse
Role of ERBB2 in Signal Transduction and Oncology	Human	Mouse
Role of Erk5 in Neuronal Survival	Human	Mouse
Signaling of Hepatocyte Growth Factor Receptor	Human	Mouse
Sprouty regulation of tyrosine kinase signals	Human	Mouse
T Cell Receptor Signaling Pathway	Human	Mouse
The Co-Stimulatory Signal During T-cell Activation	Human	Mouse
TPO Signaling Pathway	Human	Mouse
Transcription factor CREB and its extracellular signals	Human	Mouse
Trefoil Factors Initiate Mucosal Healing	Human	Mouse
Trka Receptor Signaling Pathway	Human	Mouse

Reactome: 45

NCI-Nature Pathway Interaction Database: 42

Gene Ontology: 40

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 669

IL-6/IL-6 receptor system and its role in physiological and pathological conditions.
Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M
Clin Sci (Lond). 2012
PubMed ID: 22029668
ACAP4 protein cooperates with Grb2 protein to orchestrate epidermal growth factor-stimulated integrin β1 recycling in cell migration.
Yu X, Wang F, Liu H, Adams G, Aikhionbare F, Liu D, Cao X, Fan L, Hu G, Chen Y, Frost A, Partridge E, Ding X, Yao X
J Biol Chem. 2011
PubMed ID: 22027826
Functional implications of the conformational switch in AICD peptide upon binding to Grb2-SH2 domain.
Das S, Raychaudhuri M, Sen U, Mukhopadhyay D
J Mol Biol. 2011
PubMed ID: 22001015
SCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signaling.
Draber P, Vonkova I, Stepanek O, Hrdinka M, Kucova M, Skopcova T, Otahal P, Angelisova P, Horejsi V, Yeung M, Weiss A, Brdicka T
Mol Cell Biol. 2011
PubMed ID: 21930792
A novel phospholipase D2-Grb2-WASp heterotrimer regulates leukocyte phagocytosis in a two-step mechanism.
Kantonen S, Hatton N, Mahankali M, Henkels KM, Park H, Cox D, Gomez-Cambronero J
Mol Cell Biol. 2011
PubMed ID: 21930784
HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.
Rom S, Pacifici M, Passiatore G, Aprea S, Waligorska A, Del Valle L, Peruzzi F
Biochim Biophys Acta. 2011
PubMed ID: 21745501
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Li S, Wang L, Berman M, Kong YY, Dorf ME
Immunity. 2011
PubMed ID: 21903422
A directed protein interaction network for investigating intracellular signal transduction.
Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE
Sci Signal. 2011
PubMed ID: 21900206
The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination
Sévère N, Miraoui H, Marie PJ
J Biol Chem. 2011
PubMed ID: 21596750
B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.
Schnyder T, Castello A, Feest C, Harwood NE, Oellerich T, Urlaub H, Engelke M, Wienands J, Bruckbauer A, Batista FD
Immunity. 2011
PubMed ID: 21703542
A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.
Zhang JS, Koenig A, Young C, Billadeau DD
Mol Biol Cell. 2011
PubMed ID: 21508312
Growth-factor receptor-bound protein-2 (Grb2) signaling in B cells controls lymphoid follicle organization and germinal center reaction.
Jang IK, Cronshaw DG, Xie LK, Fang G, Zhang J, Oh H, Fu YX, Gu H, Zou Y
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21508326
Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass.
Williams LH, Kalantry S, Starmer J, Magnuson T
Development. 2011
PubMed ID: 21471155
Grb2 regulates B-cell maturation, B-cell memory responses and inhibits B-cell Ca2+ signalling.
Ackermann JA, Radtke D, Maurberger A, Winkler TH, Nitschke L
EMBO J. 2011
PubMed ID: 21427701
Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.
Wang Y, Smedberg JL, Cai KQ, Capo-Chichi DC, Xu XX
Dev Dyn. 2011
PubMed ID: 20925113
Genetic incorporation of a photo-crosslinkable amino acid reveals novel protein complexes with GRB2 in mammalian cells.
Hino N, Oyama M, Sato A, Mukai T, Iraha F, Hayashi A, Kozuka-Hata H, Yamamoto T, Yokoyama S, Sakamoto K
J Mol Biol. 2011
PubMed ID: 21185312
Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.
Sun J, Wan C, Jia P, Fanous AH, Kendler KS, Riley BP, Zhao Z
Schizophr Res. 2011
PubMed ID: 21195589
Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells.
Modi H, Li L, Chu S, Rossi J, Yee JK, Bhatia R
Leukemia. 2011
PubMed ID: 21072043
Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes.
Oser M, Dovas A, Cox D, Condeelis J
Eur J Cell Biol. 2011
PubMed ID: 20850195
Initial characterization of the human central proteome.
Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Bürckstümmer T, Bennett KL, Superti-Furga G, Colinge J
BMC Syst Biol. 2011
PubMed ID: 21269460
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms.
Chadwick W, Park SS, Zhou Y, Wang L, Brenneman R, Martin B, Maudsley S
J Signal Transuct. 2011
PubMed ID: 21258655
Microarray analysis of differentially expressed genes in vaginal tissues in postmenopausal women. The role of stress urinary incontinence.
Tong J, Lang J, Zhu L
Int Urogynecol J Pelvic Floor Dysfunct. 2010
PubMed ID: 20700730
The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.
Titz B, Low T, Komisopoulou E, Chen SS, Rubbi L, Graeber TG
Oncogene. 2010
PubMed ID: 20697350
Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
Casabonne D, Reina O, Benavente Y, Becker N, Maynadie' M, Foretova L, Cocco P, Gonzalez-Neira A, Nieters A, Boffetta P, Middeldorp JM, de Sanjose S
Haematologica. 2010
PubMed ID: 21048031
Triggering Ras signalling by intracellular Francisella tularensis through recruitment of PKCα and βI to the SOS2/GrB2 complex is essential for bacterial proliferation in the cytosol.
Al-Khodor S, Abu Kwaik Y
Cell Microbiol. 2010
PubMed ID: 20618341
Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells.
Shen X, Xi G, Radhakrishnan Y, Clemmons DR
Cell Mol Life Sci. 2010
PubMed ID: 20521079
A human MAP kinase interactome.
Bandyopadhyay S, Chiang CY, Srivastava J, Gersten M, White S, Bell R, Kurschner C, Martin CH, Smoot M, Sahasrabudhe S, Barber DL, Chanda SK, Ideker T
Nat Methods. 2010
PubMed ID: 20936779
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK)-mediated signaling and anaplastic large cell lymphoma growth.
Riera L, Lasorsa E, Ambrogio C, Surrenti N, Voena C, Chiarle R
J Biol Chem. 2010
PubMed ID: 20554525
Basic study on SH2 domain of Grb2 as a molecular probe for detection of RTK activation.
Saito Y, Furukawa T, Arano Y, Fujibayashi Y, Saga T
Int J Oncol. 2010
PubMed ID: 20596655
Association study of 182 candidate genes in anorexia nervosa.
Pinheiro AP, Bulik CM, Thornton LM, Sullivan PF, Root TL, Bloss CS, Berrettini WH, Schork NJ, Kaye WH, Bergen AW, Magistretti P, Brandt H, Crawford S, Crow S, Fichter MM, Goldman D, Halmi KA, Johnson C, Kaplan AS, Keel PK, Klump KL, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB
Am J Med Genet B Neuropsychiatr Genet. 2010
PubMed ID: 20468064
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR
Mol Med. 2010
PubMed ID: 20379614
Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection.
Jang IK, Zhang J, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, Gu H
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20498059
Tyrosine phosphorylation of R3 subtype receptor-type protein tyrosine phosphatases and their complex formations with Grb2 or Fyn.
Murata Y, Mori M, Kotani T, Supriatna Y, Okazawa H, Kusakari S, Saito Y, Ohnishi H, Matozaki T
Genes Cells. 2010
PubMed ID: 20398064
Increased EFG- and PDGFalpha-receptor signaling by mutant FGF-receptor 2 contributes to osteoblast dysfunction in Apert craniosynostosis.
Miraoui H, Ringe J, Häupl T, Marie PJ
Hum Mol Genet. 2010
PubMed ID: 20124286
AMSH interacts with ESCRT-0 to regulate the stability and trafficking of CXCR4.
Sierra MI, Wright MH, Nash PD
J Biol Chem. 2010
PubMed ID: 20159979
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK.
Lin Q, Wang J, Childress C, Sudol M, Carey DJ, Yang W
Mol Cell Biol. 2010
PubMed ID: 20086093
Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric control.
McDonald CB, Seldeen KL, Deegan BJ, Bhat V, Farooq A
Arch Biochem Biophys. 2010
PubMed ID: 20005866
Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide.
Chen HH, Chen CW, Chang YY, Shen TL, Hsu CH
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010
PubMed ID: 20124721
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL.
Tanase CA
PLoS One. 2010
PubMed ID: 21179510
Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production.
Peirce MJ, Brook M, Morrice N, Snelgrove R, Begum S, Lanfrancotti A, Notley C, Hussell T, Cope AP, Wait R
PLoS One. 2010
PubMed ID: 20644716
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.
Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE
Cell Signal. 2010
PubMed ID: 19735729
Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB.
Malhotra S, Kovats S, Zhang W, Coggeshall KM
J Biol Chem. 2009
PubMed ID: 19858206
TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells.
Vanderwerf SM, Svahn J, Olson S, Rathbun RK, Harrington C, Yates J, Keeble W, Anderson DC, Anur P, Pereira NF, Pilonetto DV, Pasquini R, Bagby GC
Blood. 2009
PubMed ID: 19850743
Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
Yokoyama N, Malbon CC
J Cell Sci. 2009
PubMed ID: 19920076
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Pao-Chun L, Chan PM, Chan W, Manser E
J Biol Chem. 2009
PubMed ID: 19815557
Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.
Swiercz JM, Worzfeld T, Offermanns S
Mol Cell Biol. 2009
PubMed ID: 19805522
Expression of Grb2 distinguishes classical Hodgkin lymphomas from primary mediastinal B-cell lymphomas and other diffuse large B-cell lymphomas.
Miles RR, Mankey CC, Seiler CE, Smith LB, Teruya-Feldstein J, Hsi ED, Elenitoba-Johnson KS, Lim MS
Hum Pathol. 2009
PubMed ID: 19716163
Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor.
Liu NS, Loo LS, Loh E, Seet LF, Hong W
EMBO J. 2009
PubMed ID: 19798056
An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.
Tarcic G, Boguslavsky SK, Wakim J, Kiuchi T, Liu A, Reinitz F, Nathanson D, Takahashi T, Mischel PS, Ng T, Yarden Y
Curr Biol. 2009
PubMed ID: 19836242
KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
Zhou R, Niwa S, Homma N, Takei Y, Hirokawa N
Cell. 2009
PubMed ID: 19914172
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions.
Senis YA, Antrobus R, Severin S, Parguiña AF, Rosa I, Zitzmann N, Watson SP, García A
J Thromb Haemost. 2009
PubMed ID: 19682241
Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance.
Yu GZ, Chen Y, Wang JJ
J Cancer Res Clin Oncol. 2009
PubMed ID: 19337752
Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.
Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T, Natsume T, Sasazuki T, Suzuki H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19805304
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells.
Engels N, König LM, Heemann C, Lutz J, Tsubata T, Griep S, Schrader V, Wienands J
Nat Immunol. 2009
PubMed ID: 19668218
Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.
Tong J, Taylor P, Peterman SM, Prakash A, Moran MF
Mol Cell Proteomics. 2009
PubMed ID: 19531499
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M
Science. 2009
PubMed ID: 19608861
Themis, a T cell-specific protein important for late thymocyte development.
Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE
Nat Immunol. 2009
PubMed ID: 19597498
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection.
Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, Crockford TL, Lambe T, Domaschenz H, Kucharska EM, Zheng L, Vinuesa CG, Lenardo MJ, Goodnow CC, Cornall RJ, Schwartz RH
Nat Immunol. 2009
PubMed ID: 19597497
Cell migration is regulated by platelet-derived growth factor receptor endocytosis.
Kawada K, Upadhyay G, Ferandon S, Janarthanan S, Hall M, Vilardaga JP, Yajnik V
Mol Cell Biol. 2009
PubMed ID: 19528233
Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell. 2009
PubMed ID: 19615732
Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.
Harkiolaki M, Tsirka T, Lewitzky M, Simister PC, Joshi D, Bird LE, Jones EY, O'Reilly N, Feller SM
Structure. 2009
PubMed ID: 19523899
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate manner.
McDonald CB, Seldeen KL, Deegan BJ, Farooq A
Biochemistry. 2009
PubMed ID: 19323566
MADD, a splice variant of IG20, is indispensable for MAPK activation and protection against apoptosis upon tumor necrosis factor-alpha treatment.
Kurada BR, Li LC, Mulherkar N, Subramanian M, Prasad KV, Prabhakar BS
J Biol Chem. 2009
PubMed ID: 19289468
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
Tyrosine phosphorylation of Grb2: role in prolactin/epidermal growth factor cross talk in mammary epithelial cell growth and differentiation.
Haines E, Minoo P, Feng Z, Resalatpanah N, Nie XM, Campiglio M, Alvarez L, Cocolakis E, Ridha M, Di Fulvio M, Gomez-Cambronero J, Lebrun JJ, Ali S
Mol Cell Biol. 2009
PubMed ID: 19273609
Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.
Liu X, Liu M, Zhang J, Bai X, Ramos F, Van Remmen H, Richardson A, Liu FY, Dong LQ, Liu F
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19240254
Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase.
Parachoniak CA, Park M
J Biol Chem. 2009
PubMed ID: 19109251
Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.
Crampton SP, Wu B, Park EJ, Kim JH, Solomon C, Waterman ML, Hughes CC
PLoS One. 2009
PubMed ID: 19924227
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
Johnson KJ, Griswold IJ, O'Hare T, Corbin AS, Loriaux M, Deininger MW, Druker BJ
PLoS One. 2009
PubMed ID: 19823681
The adaptor protein Grb2 regulates cell surface Fas ligand in Schwann cells.
Thornhill PB, Cohn JB, Stanford WL, Desbarats J
Biochem Biophys Res Commun. 2008
PubMed ID: 18789888
Structural basis of the differential binding of the SH3 domains of Grb2 adaptor to the guanine nucleotide exchange factor Sos1.
McDonald CB, Seldeen KL, Deegan BJ, Farooq A
Arch Biochem Biophys. 2008
PubMed ID: 18778683
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Hansen GM, Markesich DC, Burnett MB, Zhu Q, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A
Genome Res. 2008
PubMed ID: 18799693
Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.
Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ
EMBO J. 2008
PubMed ID: 19172738
Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways.
Wang J, Yuan Y, Zhou Y, Guo L, Zhang L, Kuai X, Deng B, Pan Z, Li D, He F
J Proteome Res. 2008
PubMed ID: 18624398
Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells.
Liu Y, Zhang W
J Leukoc Biol. 2008
PubMed ID: 18559951
A quantitative atlas of mitotic phosphorylation.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18669648
Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, Slot RV, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM
J Lipid Res. 2008
PubMed ID: 18660489
In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation.
Weinger JG, Gohari P, Yan Y, Backer JM, Varnum B, Shafit-Zagardo B
J Neurochem. 2008
PubMed ID: 18346204
Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases.
Reynolds CH, Garwood CJ, Wray S, Price C, Kellie S, Perera T, Zvelebil M, Yang A, Sheppard PW, Varndell IM, Hanger DP, Anderton BH
J Biol Chem. 2008
PubMed ID: 18467332
Insulin-like growth factor-I stimulates Shc-dependent phosphatidylinositol 3-kinase activation via Grb2-associated p85 in vascular smooth muscle cells.
Radhakrishnan Y, Maile LA, Ling Y, Graves LM, Clemmons DR
J Biol Chem. 2008
PubMed ID: 18420583
Hepatocyte growth factor regulates migration of olfactory interneuron precursors in the rostral migratory stream through Met-Grb2 coupling.
Garzotto D, Giacobini P, Crepaldi T, Fasolo A, De Marchis S
J Neurosci. 2008
PubMed ID: 18524894
All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding.
McCrea HJ, Paradise S, Tomasini L, Addis M, Melis MA, De Matteis MA, De Camilli P
Biochem Biophys Res Commun. 2008
PubMed ID: 18307981
New insight into the key proteins and pathways involved in the metastasis of colorectal carcinoma.
Yu GZ, Chen Y, Long YQ, Dong D, Mu XL, Wang JJ
Oncol Rep. 2008
PubMed ID: 18425376
Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D
Mol Med. 2008
PubMed ID: 18231572
Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Hattori S
J Biol Chem. 2008
PubMed ID: 18258597
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J
EMBO J. 2008
PubMed ID: 18273061
Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma.
Zhong JL, Poghosyan Z, Pennington CJ, Scott X, Handsley MM, Warn A, Gavrilovic J, Honert K, Krüger A, Span PN, Sweep FC, Edwards DR
Mol Cancer Res. 2008
PubMed ID: 18296648
Gab1 but not Grb2 mediates tumor progression in Met overexpressing colorectal cancer cells.
Seiden-Long I, Navab R, Shih W, Li M, Chow J, Zhu CQ, Radulovich N, Saucier C, Tsao MS
Carcinogenesis. 2008
PubMed ID: 18192688
The Met tyrosine kinase receptor in development and cancer.
Gentile A, Trusolino L, Comoglio PM
Cancer Metastasis Rev. 2008
PubMed ID: 18175071
Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking.
Khan EM, Lanir R, Danielson AR, Goldkorn T
FASEB J. 2008
PubMed ID: 17971399
Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta.
Galliher-Beckley AJ, Schiemann WP
Carcinogenesis. 2008
PubMed ID: 18174260
Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation.
Kondo A, Hirayama N, Sugito Y, Shono M, Tanaka T, Kitamura N
J Biol Chem. 2008
PubMed ID: 18003605
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Chandramouli S, Yu CY, Yusoff P, Lao DH, Leong HF, Mizuno K, Guy GR
J Biol Chem. 2008
PubMed ID: 17974561
The function study on the interaction between Grb2 and AMPK.
Pan Z, Wang J, Yin X, Xie P, Yang J, Jiang J, Zhang L, He F
Mol Cell Biochem. 2008
PubMed ID: 17849173
Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB
Mol Cell Biol. 2007
PubMed ID: 17923684
Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.
Morimatsu M, Takagi H, Ota KG, Iwamoto R, Yanagida T, Sako Y
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17991782
Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl.
Sun J, Pedersen M, Bengtsson S, Rönnstrand L
Exp Cell Res. 2007
PubMed ID: 17904548
Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.
Martínez N, García-Domínguez CA, Domingo B, Oliva JL, Zarich N, Sánchez A, Gutiérrez-Eisman S, Llopis J, Rojas JM
Cell Signal. 2007
PubMed ID: 17689925
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W
Brief Funct Genomic Proteomic. 2007
PubMed ID: 17967808
Inhibition of tumor metastasis by a growth factor receptor bound protein 2 Src homology 2 domain-binding antagonist.
Giubellino A, Gao Y, Lee S, Lee MJ, Vasselli JR, Medepalli S, Trepel JB, Burke TR, Bottaro DP
Cancer Res. 2007
PubMed ID: 17616655
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomes.
Grandal MV, Zandi R, Pedersen MW, Willumsen BM, van Deurs B, Poulsen HS
Carcinogenesis. 2007
PubMed ID: 17372273
Specific Grb2-mediated interactions regulate clathrin-dependent endocytosis of the cMet-tyrosine kinase.
Li N, Lorinczi M, Ireton K, Elferink LA
J Biol Chem. 2007
PubMed ID: 17449471
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
Structural and energetic aspects of Grb2-SH2 domain-swapping.
Benfield AP, Whiddon BB, Clements JH, Martin SF
Arch Biochem Biophys. 2007
PubMed ID: 17466257
Grb2 is required for atherosclerotic lesion formation.
Proctor BM, Ren J, Chen Z, Schneider JG, Coleman T, Lupu TS, Semenkovich CF, Muslin AJ
Arterioscler Thromb Vasc Biol. 2007
PubMed ID: 17363695
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L
Cancer Res. 2007
PubMed ID: 17409413
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Jiang Y, Cheng H
Leuk Res. 2007
PubMed ID: 16938345
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF.
Di Fulvio M, Frondorf K, Henkels KM, Lehman N, Gomez-Cambronero J
J Mol Biol. 2007
PubMed ID: 17276458
Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.
Erkeland SJ, Aarts LH, Irandoust M, Roovers O, Klomp A, Valkhof M, Gits J, Eyckerman S, Tavernier J, Touw IP
Oncogene. 2007
PubMed ID: 17001306
Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK.
Watanabe K, Ma M, Hirabayashi K, Gurusamy N, Veeraveedu PT, Prakash P, Zhang S, Muslin AJ, Kodama M, Aizawa Y
Am J Physiol Heart Circ Physiol. 2007
PubMed ID: 17040971
Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells.
Stork B, Neumann K, Goldbeck I, Alers S, Kähne T, Naumann M, Engelke M, Wienands J
EMBO J. 2007
PubMed ID: 17290227
Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines.
Bonaccorsi L, Nosi D, Muratori M, Formigli L, Forti G, Baldi E
J Mol Endocrinol. 2007
PubMed ID: 17242169
DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2.
Shinoda T, Taya S, Tsuboi D, Hikita T, Matsuzawa R, Kuroda S, Iwamatsu A, Kaibuchi K
J Neurosci. 2007
PubMed ID: 17202467
Amyloid precursor protein modulates ERK-1 and -2 signaling.
Venezia V, Nizzari M, Repetto E, Violani E, Corsaro A, Thellung S, Villa V, Carlo P, Schettini G, Florio T, Russo C
Ann N Y Acad Sci. 2006
PubMed ID: 17384289
Detection in primary chronic myeloid leukaemia cells of p210BCR-ABL1 in complexes with adaptor proteins CBL, CRKL, and GRB2.
Patel H, Marley SB, Gordon MY
Genes Chromosomes Cancer. 2006
PubMed ID: 16955467
Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.
Lamalice L, Houle F, Huot J
J Biol Chem. 2006
PubMed ID: 16966330
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M
Cell. 2006
PubMed ID: 17081983
The Grb2/Mek pathway represses Nanog in murine embryonic stem cells.
Hamazaki T, Kehoe SM, Nakano T, Terada N
Mol Cell Biol. 2006
PubMed ID: 16908534
Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation.
Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V
Biochem Biophys Res Commun. 2006
PubMed ID: 16899217
A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.
Giannoni E, Raugei G, Chiarugi P, Ramponi G
Biochem Biophys Res Commun. 2006
PubMed ID: 16890200
Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1.
Houtman JC, Yamaguchi H, Barda-Saad M, Braiman A, Bowden B, Appella E, Schuck P, Samelson LE
Nat Struct Mol Biol. 2006
PubMed ID: 16906159
Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA).
Wu SL, Kim J, Bandle RW, Liotta L, Petricoin E, Karger BL
Mol Cell Proteomics. 2006
PubMed ID: 16799092
A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM
Genomics. 2006
PubMed ID: 16730941
Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1.
Zarich N, Oliva JL, Martínez N, Jorge R, Ballester A, Gutiérrez-Eisman S, García-Vargas S, Rojas JM
Mol Biol Cell. 2006
PubMed ID: 16760435
Grb2 and Gads exhibit different interactions with CD28 and play distinct roles in CD28-mediated costimulation.
Watanabe R, Harada Y, Takeda K, Takahashi J, Ohnuki K, Ogawa S, Ohgai D, Kaibara N, Koiwai O, Tanabe K, Toma H, Sugamura K, Abe R
J Immunol. 2006
PubMed ID: 16818765
Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA.
Gavrieli M, Murphy KM
Biochem Biophys Res Commun. 2006
PubMed ID: 16725108
EGF-ERBB signalling: towards the systems level.
Citri A, Yarden Y
Nat Rev Mol Cell Biol. 2006
PubMed ID: 16829981
Two mechanistically distinct forms of endocytosis in adrenal chromaffin cells: Differential effects of SH3 domains and amphiphysin antagonism.
Elhamdani A, Azizi F, Solomaha E, Palfrey HC, Artalejo CR
FEBS Lett. 2006
PubMed ID: 16696976
The elucidation of novel SH2 binding sites on PLD2.
Di Fulvio M, Lehman N, Lin X, Lopez I, Gomez-Cambronero J
Oncogene. 2006
PubMed ID: 16407827
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway.
Chazaud C, Yamanaka Y, Pawson T, Rossant J
Dev Cell. 2006
PubMed ID: 16678776
NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells.
Upshaw JL, Arneson LN, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ
Nat Immunol. 2006
PubMed ID: 16582911
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C
Nature. 2006
PubMed ID: 16625196
GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells.
Teal HE, Ni S, Xu J, Finkelstein LD, Cheng AM, Paulson RF, Feng GS, Correll PH
Oncogene. 2006
PubMed ID: 16314834
HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.
Toschi E, Bacigalupo I, Strippoli R, Chiozzini C, Cereseto A, Falchi M, Nappi F, Sgadari C, Barillari G, Mainiero F, Ensoli B
Mol Biol Cell. 2006
PubMed ID: 16436505
Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein.
Lim JY, Kim H, Jeun SS, Kang SG, Lee KJ
Biochem Biophys Res Commun. 2006
PubMed ID: 16405865
LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.
Ahn E, Lee H, Yun Y
Blood. 2006
PubMed ID: 16249387
Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases.
Honma M, Higuchi O, Shirakata M, Yasuda T, Shibuya H, Iemura S, Natsume T, Yamanashi Y
Genes Cells. 2006
PubMed ID: 16436051
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.
Kärkkäinen S, Hiipakka M, Wang JH, Kleino I, Vähä-Jaakkola M, Renkema GH, Liss M, Wagner R, Saksela K
EMBO Rep. 2006
PubMed ID: 16374509
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
Moeller ML, Shi Y, Reichardt LF, Ethell IM
J Biol Chem. 2006
PubMed ID: 16298995
Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1.
Jiang ST, Chiou YY, Wang E, Lin HK, Lin YT, Chi YC, Wang CK, Tang MJ, Li H
Am J Pathol. 2006
PubMed ID: 16400024
Activation of the epidermal growth factor (EGF) receptor induces formation of EGF receptor- and Grb2-containing clathrin-coated pits.
Johannessen LE, Pedersen NM, Pedersen KW, Madshus IH, Stang E
Mol Cell Biol. 2006
PubMed ID: 16382132
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
Efficient suppression of FGF-2-induced ERK activation by the cooperative interaction among mammalian Sprouty isoforms.
Ozaki K, Miyazaki S, Tanimura S, Kohno M
J Cell Sci. 2005
PubMed ID: 16339969
T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315.
Gelkop S, Gish GD, Babichev Y, Pawson T, Isakov N
J Immunol. 2005
PubMed ID: 16339550
Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.
Roskoski R
Biochem Biophys Res Commun. 2005
PubMed ID: 16129412
Uncoupling ligand-dependent and -independent mechanisms for mitogen-activated protein kinase activation by the murine Ron receptor tyrosine kinase.
Wei X, Ni S, Correll PH
J Biol Chem. 2005
PubMed ID: 16103119
Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase.
Ren SY, Xue F, Feng J, Skorski T
Exp Hematol. 2005
PubMed ID: 16219545
Grb2 negatively regulates epidermal growth factor-induced phospholipase C-gamma1 activity through the direct interaction with tyrosine-phosphorylated phospholipase C-gamma1.
Choi JH, Hong WP, Yun S, Kim HS, Lee JR, Park JB, Bae YS, Ryu SH, Suh PG
Cell Signal. 2005
PubMed ID: 16038803
Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma.
Halupa A, Chohan M, Stickle NH, Beattie BK, Miller BA, Barber DL
Exp Cell Res. 2005
PubMed ID: 15953601
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.
Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y
Proc Natl Acad Sci U S A. 2005
PubMed ID: 15983387
Kinetics of Src homology 3 domain association with the proline-rich domain of dynamins: specificity, occlusion, and the effects of phosphorylation.
Solomaha E, Szeto FL, Yousef MA, Palfrey HC
J Biol Chem. 2005
PubMed ID: 15834155
Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.
Martín M, Del Valle JM, Saborit I, Engel P
J Immunol. 2005
PubMed ID: 15879090
Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells.
Xie Y, Wang Y, Sun T, Wang F, Trostinskaia A, Puscheck E, Rappolee DA
Mol Reprod Dev. 2005
PubMed ID: 15736129
Domain-specific function of ShcC docking protein in neuroblastoma cells.
Miyake I, Hakomori Y, Misu Y, Nakadate H, Matsuura N, Sakamoto M, Sakai R
Oncogene. 2005
PubMed ID: 15735675
Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.
Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M
J Gen Virol. 2005
PubMed ID: 15784897
Cooperation and selectivity of the two Grb2 binding sites of p52Shc in T-cell antigen receptor signaling to Ras family GTPases and Myc-dependent survival.
Patrussi L, Savino MT, Pellegrini M, Paccani SR, Migliaccio E, Plyte S, Lanfrancone L, Pelicci PG, Baldari CT
Oncogene. 2005
PubMed ID: 15688026
Transient activation of Ras-dependent signalling at the early stages of Herbimycin A induced erythroid differentiation of human K562 cells.
Drobot L, Husak Z, Ilnytska O, Igumentseva N, Oleksyn H, Kusen' S
Exp Oncol. 2005
PubMed ID: 15812354
Protein photo-cross-linking in mammalian cells by site-specific incorporation of a photoreactive amino acid.
Hino N, Okazaki Y, Kobayashi T, Hayashi A, Sakamoto K, Yokoyama S
Nat Methods. 2005
PubMed ID: 15782189
Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis.
Huang F, Sorkin A
Mol Biol Cell. 2005
PubMed ID: 15635092
A novel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation.
Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P
J Biol Chem. 2005
PubMed ID: 15574420
Novel interaction partners of the TPR/MET tyrosine kinase.
Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW
FASEB J. 2005
PubMed ID: 15546961
Characterization of VIK-1: a new Vav-interacting Kruppel-like protein.
Houlard M, Romero-Portillo F, Germani A, Depaux A, Regnier-Ricard F, Gisselbrecht S, Varin-Blank N
Oncogene. 2005
PubMed ID: 15558030
Phosphotyrosine interactome of the ErbB-receptor kinase family.
Schulze WX, Deng L, Mann M
Mol Syst Biol. 2005
PubMed ID: 16729043
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis.
Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E
PLoS Biol. 2005
PubMed ID: 15630473
Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
Isnardi I, Lesourne R, Bruhns P, Fridman WH, Cambier JC, Daëron M
J Biol Chem. 2004
PubMed ID: 15456754
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Schuetz G, Rosário M, Grimm J, Boeckers TM, Gundelfinger ED, Birchmeier W
J Cell Biol. 2004
PubMed ID: 15569713
Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas.
Watahiki A, Waki K, Hayatsu N, Shiraki T, Kondo S, Nakamura M, Sasaki D, Arakawa T, Kawai J, Harbers M, Hayashizaki Y, Carninci P
Nat Methods. 2004
PubMed ID: 15782199
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells.
Galperin E, Verkhusha VV, Sorkin A
Nat Methods. 2004
PubMed ID: 15782196
Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase.
Shutes A, Berzat AC, Cox AD, Der CJ
Curr Biol. 2004
PubMed ID: 15556869
Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2.
Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V
Oncogene. 2004
PubMed ID: 15467741
Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes.
Stork B, Engelke M, Frey J, Horejsí V, Hamm-Baarke A, Schraven B, Kurosaki T, Wienands J
Immunity. 2004
PubMed ID: 15539154
grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice.
Cully M, Elia A, Ong SH, Stambolic V, Pawson T, Tsao MS, Mak TW
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15492213
Regulation of growth factor receptor bound 2 by electroconvulsive seizure.
Newton SS, Collier EF, Bennett AH, Russell DS, Duman RS
Brain Res Mol Brain Res. 2004
PubMed ID: 15469895
Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
Zhu M, Liu Y, Koonpaew S, Granillo O, Zhang W
J Exp Med. 2004
PubMed ID: 15477350
Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P
J Exp Med. 2004
PubMed ID: 15477348
Signal transduction via the stem cell factor receptor/c-Kit.
Rönnstrand L
Cell Mol Life Sci. 2004
PubMed ID: 15526160
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma.
Tacconelli A, Farina AR, Cappabianca L, Desantis G, Tessitore A, Vetuschi A, Sferra R, Rucci N, Argenti B, Screpanti I, Gulino A, Mackay AR
Cancer Cell. 2004
PubMed ID: 15488758
Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells.
Hayashi K, Shibata K, Morita T, Iwasaki K, Watanabe M, Sobue K
J Biol Chem. 2004
PubMed ID: 15272025
Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branching.
Degl'Innocenti D, Arighi E, Popsueva A, Sangregorio R, Alberti L, Rizzetti MG, Ferrario C, Sariola H, Pierotti MA, Borrello MG
Oncogene. 2004
PubMed ID: 15326489
The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
Laurent CE, Smithgall TE
Exp Cell Res. 2004
PubMed ID: 15302586
MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.
Higuchi T, Orita T, Katsuya K, Yamasaki Y, Akiyama K, Li H, Yamamoto T, Saito Y, Nakamura M
Mol Cell Biol. 2004
PubMed ID: 15314156
Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.
Wilhelmsen K, Copp J, Glenn G, Hoffman RC, Tucker P, van der Geer P
Mol Cell Proteomics. 2004
PubMed ID: 15215307
c-Cbl-mediated ubiquitinylation is required for epidermal growth factor receptor exit from the early endosomes.
Ravid T, Heidinger JM, Gee P, Khan EM, Goldkorn T
J Biol Chem. 2004
PubMed ID: 15210722
Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions.
Kaput J, Klein KG, Reyes EJ, Kibbe WA, Cooney CA, Jovanovic B, Visek WJ, Wolff GL
Physiol Genomics. 2004
PubMed ID: 15306695
A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction.
Zhou D, Chen B, Ye JJ, Chen S
Oncogene. 2004
PubMed ID: 15122321
Changes in structural dynamics of the Grb2 adaptor protein upon binding of phosphotyrosine ligand to its SH2 domain.
de Mol NJ, Catalina MI, Fischer MJ, Broutin I, Maier CS, Heck AJ
Biochim Biophys Acta. 2004
PubMed ID: 15210125
Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
Wang JF, Zhang X, Groopman JE
J Biol Chem. 2004
PubMed ID: 15102829
Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric.
Brooks SR, Kirkham PM, Freeberg L, Carter RH
J Immunol. 2004
PubMed ID: 15187135
Catalase binds Grb2 in tumor cells when stimulated with serum or ligands for integrin receptors.
Yano S, Arroyo N, Yano N
Free Radic Biol Med. 2004
PubMed ID: 15182856
Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.
Zhou D, Noviello C, D'Ambrosio C, Scaloni A, D'Adamio L
J Biol Chem. 2004
PubMed ID: 15054097
Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor alpha in breast cancer cells.
Yang Z, Barnes CJ, Kumar R
Clin Cancer Res. 2004
PubMed ID: 15173068
A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase.
Million RP, Harakawa N, Roumiantsev S, Varticovski L, Van Etten RA
Mol Cell Biol. 2004
PubMed ID: 15143164
Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.
Huang F, Khvorova A, Marshall W, Sorkin A
J Biol Chem. 2004
PubMed ID: 14985334
Identification of NPM-ALK interacting proteins by tandem mass spectrometry.
Crockett DK, Lin Z, Elenitoba-Johnson KS, Lim MS
Oncogene. 2004
PubMed ID: 14968112
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
Koonpaew S, Janssen E, Zhu M, Zhang W
J Biol Chem. 2004
PubMed ID: 14722116
A novel proteomic screen for peptide-protein interactions.
Schulze WX, Mann M
J Biol Chem. 2004
PubMed ID: 14679214
The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.
Macdonald A, Crowder K, Street A, McCormick C, Harris M
J Gen Virol. 2004
PubMed ID: 14993658
Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor.
Ren Y, Meng S, Mei L, Zhao ZJ, Jove R, Wu J
J Biol Chem. 2004
PubMed ID: 14665621
Bioinformatics and cellular signaling.
Papin J, Subramaniam S
Curr Opin Biotechnol. 2004
PubMed ID: 15102471
[Design of new anti-tumor agents interrupting deregulated signaling pathways induced by tyrosine kinase proteins. Inhibition of protein-protein interaction involving Grb2]
Vidal M, Liu WQ, Gril B, Assayag F, Poupon MF, Garbay C
J Soc Biol. 2004
PubMed ID: 15368963
Coexistence of phosphotyrosine-dependent and -independent interactions between Cbl and Bcr-Abl.
Gaston I, Johnson KJ, Oda T, Bhat A, Reis M, Langdon W, Shen L, Deininger MW, Druker BJ
Exp Hematol. 2004
PubMed ID: 14725908
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM
Genomics. 2004
PubMed ID: 14667819
Met, metastasis, motility and more.
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF
Nat Rev Mol Cell Biol. 2003
PubMed ID: 14685170
Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain.
Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N
J Biol Chem. 2003
PubMed ID: 13129930
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.
Hur EM, Son M, Lee OH, Choi YB, Park C, Lee H, Yun Y
J Exp Med. 2003
PubMed ID: 14610044
Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling.
Agazie YM, Hayman MJ
Mol Cell Biol. 2003
PubMed ID: 14560030
Adaptor signalling proteins Grb2 and Grb7 are recruited by human G6f, a novel member of the immunoglobulin superfamily encoded in the MHC.
De Vet EC, Aguado B, Campbell RD
Biochem J. 2003
PubMed ID: 12852788
Grb2 is required for the development of neointima in response to vascular injury.
Zhang S, Ren J, Khan MF, Cheng AM, Abendschein D, Muslin AJ
Arterioscler Thromb Vasc Biol. 2003
PubMed ID: 12842846
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins.
Howard PL, Chia MC, Del Rizzo S, Liu FF, Pawson T
Proc Natl Acad Sci U S A. 2003
PubMed ID: 13679576
EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.
Vindis C, Cerretti DP, Daniel TO, Huynh-Do U
J Cell Biol. 2003
PubMed ID: 12925710
Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development.
Khamzina L, Gruppuso PA, Wands JR
Gastroenterology. 2003
PubMed ID: 12891559
Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation.
Jiang X, Sorkin A
Traffic. 2003
PubMed ID: 12839496
TGF-beta 1 modulation of IGF-I signaling pathway in rat thyroid epithelial cells.
Mincione G, Esposito DL, Di Marcantonio MC, Piccirelli A, Cama A, Colletta G
Exp Cell Res. 2003
PubMed ID: 12837295
The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation.
Sayeski PP, Ali MS
Exp Cell Res. 2003
PubMed ID: 12837289
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
Moeller SJ, Head ED, Sheaff RJ
Mol Cell Biol. 2003
PubMed ID: 12748278
The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ
J Biol Chem. 2003
PubMed ID: 12624098
A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling.
Esposito DL, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon MJ, Cama A
J Clin Endocrinol Metab. 2003
PubMed ID: 12679424
p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death.
Lu Y, Pan ZZ, Devaux Y, Ray P
J Biol Chem. 2003
PubMed ID: 12529371
p21-activated kinase 1 (PAK1) interacts with the Grb2 adapter protein to couple to growth factor signaling.
Puto LA, Pestonjamasp K, King CC, Bokoch GM
J Biol Chem. 2003
PubMed ID: 12522133
Differential regulation of cell motility and invasion by FAK.
Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, Spencer KS, Cheresh DA, Schlaepfer DD
J Cell Biol. 2003
PubMed ID: 12615911
The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis.
Zhang S, Weinheimer C, Courtois M, Kovacs A, Zhang CE, Cheng AM, Wang Y, Muslin AJ
J Clin Invest. 2003
PubMed ID: 12639989
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M
Nat Biotechnol. 2003
PubMed ID: 12577067
The adaptor function of SHP-2 downstream of the prolactin receptor is required for the recruitment of p29, a substrate of SHP-2.
Minoo P, Chughtai N, Campiglio M, Stein-Gerlach M, Lebrun JJ, Ullrich A, Ali S
Cell Signal. 2003
PubMed ID: 12531430
Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity.
Tong J, Elowe S, Nash P, Pawson T
J Biol Chem. 2003
PubMed ID: 12486127
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.
Palka HL, Park M, Tonks NK
J Biol Chem. 2003
PubMed ID: 12475979
LAB: a new membrane-associated adaptor molecule in B cell activation.
Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W
Nat Immunol. 2003
PubMed ID: 12514734
Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
Johnson KR, Lane PW, Cook SA, Harris BS, Ward-Bailey PF, Bronson RT, Lyons BL, Shultz LD, Davisson MT
Genomics. 2003
PubMed ID: 12573256
Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.
Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F
J Neurochem. 2003
PubMed ID: 12558988
NEPH1 defines a novel family of podocin interacting proteins.
Sellin L, Huber TB, Gerke P, Quack I, Pavenstädt H, Walz G
FASEB J. 2003
PubMed ID: 12424224
Protein-tyrosine-phosphatase 1B activation is regulated developmentally in muscle of neonatal pigs.
Suryawan A, Davis TA
Am J Physiol Endocrinol Metab. 2003
PubMed ID: 12388170
Endocytosis of epidermal growth factor receptor regulated by Grb2-mediated recruitment of the Rab5 GTPase-activating protein RN-tre.
Martinu L, Santiago-Walker A, Qi H, Chou MM
J Biol Chem. 2002
PubMed ID: 12399475
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin.
Hafizi S, Alindri F, Karlsson R, Dahlbäck B
Biochem Biophys Res Commun. 2002
PubMed ID: 12470648
Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.
Brdicka T, Imrich M, Angelisová P, Brdicková N, Horváth O, Spicka J, Hilgert I, Lusková P, Dráber P, Novák P, Engels N, Wienands J, Simeoni L, Osterreicher J, Aguado E, Malissen M, Schraven B, Horejsí V
J Exp Med. 2002
PubMed ID: 12486104
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
Zhu M, Janssen E, Leung K, Zhang W
J Biol Chem. 2002
PubMed ID: 12359715
Fear memory formation involves p190 RhoGAP and ROCK proteins through a GRB2-mediated complex.
Lamprecht R, Farb CR, LeDoux JE
Neuron. 2002
PubMed ID: 12441060
Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Russo C, Dolcini V, Salis S, Venezia V, Violani E, Carlo P, Zambrano N, Russo T, Schettini G
Ann N Y Acad Sci. 2002
PubMed ID: 12485888
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
Hanafusa H, Torii S, Yasunaga T, Nishida E
Nat Cell Biol. 2002
PubMed ID: 12402043
Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade.
Pratt RL, Kinch MS
Oncogene. 2002
PubMed ID: 12400011
SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation.
Wu L, Yu Z, Shen SH
J Biol Chem. 2002
PubMed ID: 12171928
Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2.
Benesch S, Lommel S, Steffen A, Stradal TE, Scaplehorn N, Way M, Wehland J, Rottner K
J Biol Chem. 2002
PubMed ID: 12147689
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.
Pelicci G, Troglio F, Bodini A, Melillo RM, Pettirossi V, Coda L, De Giuseppe A, Santoro M, Pelicci PG
Mol Cell Biol. 2002
PubMed ID: 12242309
Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Russo C, Dolcini V, Salis S, Venezia V, Zambrano N, Russo T, Schettini G
J Biol Chem. 2002
PubMed ID: 12084708
The COOH-terminus of parathyroid hormone-related protein (PTHrP) interacts with beta-arrestin 1B.
Conlan LA, Martin TJ, Gillespie MT
FEBS Lett. 2002
PubMed ID: 12220636
Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase.
He Y, Nakao H, Tan SL, Polyak SJ, Neddermann P, Vijaysri S, Jacobs BL, Katze MG
J Virol. 2002
PubMed ID: 12186904
Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1.
Dalle S, Imamura T, Rose DW, Worrall DS, Ugi S, Hupfeld CJ, Olefsky JM
Mol Cell Biol. 2002
PubMed ID: 12167719
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB
Biochemistry. 2002
PubMed ID: 12186560
ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation.
Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH
Oncogene. 2002
PubMed ID: 12173038
TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.
Ho JM, Nguyen MH, Dierov JK, Badger KM, Beattie BK, Tartaro P, Haq R, Zanke BW, Carroll MP, Barber DL
Blood. 2002
PubMed ID: 12149229
A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling.
Berry DM, Nash P, Liu SK, Pawson T, McGlade CJ
Curr Biol. 2002
PubMed ID: 12176364
Organization of the mouse Ruk locus and expression of isoforms in mouse tissues.
Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N
Gene. 2002
PubMed ID: 12242006
ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.
Liu HY, Meakin SO
J Biol Chem. 2002
PubMed ID: 12006576
Specificity and affinity motifs for Grb2 SH2-ligand interactions.
Kessels HW, Ward AC, Schumacher TN
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12084912
Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation.
Zheng XM, Resnick RJ, Shalloway D
J Biol Chem. 2002
PubMed ID: 11923305
Basic fibroblast growth factor: effects on matrix remodeling, receptor expression, and transduction pathway in human periosteal fibroblasts with FGFR2 gene mutation.
Bodo M, Lilli C, Aisa MC, Scapoli L, Bellucci C, Rinaldi E, Tosi L, Baroni T, Conte C, Bellocchio S, Carinci F, Stabellini G, Carinci P
J Interferon Cytokine Res. 2002
PubMed ID: 12162872
Insulin receptor substrate 4 associates with the protein IRAS.
Sano H, Liu SC, Lane WS, Piletz JE, Lienhard GE
J Biol Chem. 2002
PubMed ID: 11912194
Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178).
Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O
FEBS Lett. 2002
PubMed ID: 12023017
Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.
Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW
J Biol Chem. 2002
PubMed ID: 11877424
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A
Proc Natl Acad Sci U S A. 2002
PubMed ID: 11997436
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells.
Jiang X, Sorkin A
Mol Biol Cell. 2002
PubMed ID: 12006650
Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement.
Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C
Biochem J. 2002
PubMed ID: 11964172
Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus.
Scaplehorn N, Holmström A, Moreau V, Frischknecht F, Reckmann I, Way M
Curr Biol. 2002
PubMed ID: 12007418
MICAL, a novel CasL interacting molecule, associates with vimentin.
Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H
J Biol Chem. 2002
PubMed ID: 11827972
Leptin promotes the tyrosine phosphorylation of SHC proteins and SHC association with GRB2.
Gualillo O, Eiras S, White DW, Diéguez C, Casanueva FF
Mol Cell Endocrinol. 2002
PubMed ID: 11997181
UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug.
Oneyama C, Nakano H, Sharma SV
Oncogene. 2002
PubMed ID: 11960376
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.
Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I
Nature. 2002
PubMed ID: 11894095
The structural basis of localization and signaling by the focal adhesion targeting domain.
Arold ST, Hoellerer MK, Noble ME
Structure. 2002
PubMed ID: 12005431
Investigation of the GRB2, GRB7, and CSH1 genes as candidates for the Silver-Russell syndrome (SRS) on chromosome 17q.
Hitchins MP, Abu-Amero S, Apostolidou S, Monk D, Stanier P, Preece MA, Moore GE
J Med Genet. 2002
PubMed ID: 11897833
The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation.
Hill RJ, Zozulya S, Lu YL, Ward K, Gishizky M, Jallal B
Exp Hematol. 2002
PubMed ID: 11882361
Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells.
Song C, Perides G, Liu YF
J Biol Chem. 2002
PubMed ID: 11733534
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.
Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR
J Biol Chem. 2002
PubMed ID: 11741929
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Nioche P, Liu WQ, Broutin I, Charbonnier F, Latreille MT, Vidal M, Roques B, Garbay C, Ducruix A
J Mol Biol. 2002
PubMed ID: 11827484
A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling.
Waterman H, Katz M, Rubin C, Shtiegman K, Lavi S, Elson A, Jovin T, Yarden Y
EMBO J. 2002
PubMed ID: 11823423
The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development.
Chan R, Hardy WR, Laing MA, Hardy SE, Muller WJ
Mol Cell Biol. 2002
PubMed ID: 11809799
'Srcasm: a novel Src activating and signaling molecule.
Seykora JT, Mei L, Dotto GP, Stein PL
J Biol Chem. 2002
PubMed ID: 11711534
PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2.
Lynch DK, Daly RJ
EMBO J. 2002
PubMed ID: 11782427
Sam68 associates with the SH3 domains of Grb2 recruiting GAP to the Grb2-SOS complex in insulin receptor signaling.
Najib S, Sánchez-Margalet V
J Cell Biochem. 2002
PubMed ID: 12112020
Solution structure of N-terminal SH3 domain of Vav and the recognition site for Grb2 C-terminal SH3 domain.
Ogura K, Nagata K, Horiuchi M, Ebisui E, Hasuda T, Yuzawa S, Nishida M, Hatanaka H, Inagaki F
J Biomol NMR. 2002
PubMed ID: 11885979
Gab3, a new DOS/Gab family member, facilitates macrophage differentiation.
Wolf I, Jenkins BJ, Liu Y, Seiffert M, Custodio JM, Young P, Rohrschneider LR
Mol Cell Biol. 2002
PubMed ID: 11739737
Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth.
Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC
J Biol Chem. 2001
PubMed ID: 11606575
The small 11-kDa protein from B19 parvovirus binds growth factor receptor-binding protein 2 in vitro in a Src homology 3 domain/ligand-dependent manner.
Fan MM, Tamburic L, Shippam-Brett C, Zagrodney DB, Astell CR
Virology. 2001
PubMed ID: 11878897
Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.
Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan DR, Kabelitz D, Feller SM, Janssen O
FEBS Lett. 2001
PubMed ID: 11741599
Mammalian sprouty proteins inhibit cell growth and differentiation by preventing ras activation.
Gross I, Bassit B, Benezra M, Licht JD
J Biol Chem. 2001
PubMed ID: 11585837
Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling.
Li S, Couvillon AD, Brasher BB, Van Etten RA
EMBO J. 2001
PubMed ID: 11726515
Effects of age on elements of insulin-signaling pathway in central nervous system of rats.
Fernandes ML, Saad MJ, Velloso LA
Endocrine. 2001
PubMed ID: 11954667
PrPC directly interacts with proteins involved in signaling pathways.
Spielhaupter C, Schätzl HM
J Biol Chem. 2001
PubMed ID: 11571277
CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1.
Otipoby KL, Draves KE, Clark EA
J Biol Chem. 2001
PubMed ID: 11551923
ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen.
Nicholson PR, Empereur S, Glover HR, Dilworth SM
EMBO J. 2001
PubMed ID: 11707405
ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.
Ong SH, Dilworth S, Hauck-Schmalenberger I, Pawson T, Kiefer F
EMBO J. 2001
PubMed ID: 11707404
The ORF3 protein of hepatitis E virus binds to Src homology 3 domains and activates MAPK.
Korkaya H, Jameel S, Gupta D, Tyagi S, Kumar R, Zafrullah M, Mazumdar M, Lal SK, Xiaofang L, Sehgal D, Das SR, Sahal D
J Biol Chem. 2001
PubMed ID: 11518702
Identification and characterization of a synaptojanin 2 splice isoform predominantly expressed in nerve terminals.
Nemoto Y, Wenk MR, Watanabe M, Daniell L, Murakami T, Ringstad N, Yamada H, Takei K, De Camilli P
J Biol Chem. 2001
PubMed ID: 11498538
Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein.
Onishi-Haraikawa Y, Funaki M, Gotoh N, Shibuya M, Inukai K, Katagiri H, Fukushima Y, Anai M, Ogihara T, Sakoda H, Ono H, Kikuchi M, Oka Y, Asano T
Biochem Biophys Res Commun. 2001
PubMed ID: 11606067
Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2.
Zamora-Leon SP, Lee G, Davies P, Shafit-Zagardo B
J Biol Chem. 2001
PubMed ID: 11546790
mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation.
Satoh S, Tominaga T
J Biol Chem. 2001
PubMed ID: 11509578
Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein.
Tu Z, Ninos JM, Ma Z, Wang JW, Lemos MP, Desponts C, Ghansah T, Howson JM, Kerr WG
Blood. 2001
PubMed ID: 11567986
Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2.
Wheeler M, Domin J
Mol Cell Biol. 2001
PubMed ID: 11533253
MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.
Goitsuka R, Tatsuno A, Ishiai M, Kurosaki T, Kitamura D
J Biol Chem. 2001
PubMed ID: 11463797
Mouse alpha1-syntrophin binding to Grb2: further evidence of a role for syntrophin in cell signaling.
Oak SA, Russo K, Petrucci TC, Jarrett HW
Biochemistry. 2001
PubMed ID: 11551227
Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.
Richnau N, Aspenström P
J Biol Chem. 2001
PubMed ID: 11431473
Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers.
Kim H, Lee YH, Won J, Yun Y
Biochem Biophys Res Commun. 2001
PubMed ID: 11527382
ERK regulates the hepatocyte growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase.
Yu CF, Roshan B, Liu ZX, Cantley LG
J Biol Chem. 2001
PubMed ID: 11445578
Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells.
Luo H, Wan X, Wu Y, Wu J
J Immunol. 2001
PubMed ID: 11466354
The inhibitory role of DOC-2/DAB2 in growth factor receptor-mediated signal cascade. DOC-2/DAB2-mediated inhibition of ERK phosphorylation via binding to Grb2.
Zhou J, Hsieh JT
J Biol Chem. 2001
PubMed ID: 11371563
Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.
Simpson A, Uitto J, Rodeck U, Mahoney MG
Gene. 2001
PubMed ID: 11483358
Inhibition of insulin-like growth factor-I signaling by ethanol in neuronal cells.
Hallak H, Seiler AE, Green JS, Henderson A, Ross BN, Rubin R
Alcohol Clin Exp Res. 2001
PubMed ID: 11505033
Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-alpha.
Engels N, Wollscheid B, Wienands J
Eur J Immunol. 2001
PubMed ID: 11449366
Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system.
Yamada M, Suzuki K, Mizutani M, Asada A, Matozaki T, Ikeuchi T, Koizumi S, Hatanaka H
J Biochem. 2001
PubMed ID: 11432792
Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner.
Crostella L, Lidder S, Williams R, Skouteris GG
Oncogene. 2001
PubMed ID: 11439336
Epidermal growth factor stimulation of the ACK1/Dbl pathway in a Cdc42 and Grb2-dependent manner.
Kato-Stankiewicz J, Ueda S, Kataoka T, Kaziro Y, Satoh T
Biochem Biophys Res Commun. 2001
PubMed ID: 11394904
Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
Pfrepper KI, Marie-Cardine A, Simeoni L, Kuramitsu Y, Leo A, Spicka J, Hilgert I, Scherer J, Schraven B
Eur J Immunol. 2001
PubMed ID: 11433379
SH3 ligands in the dopamine D3 receptor.
Oldenhof J, Ray A, Vickery R, Van Tol HH
Cell Signal. 2001
PubMed ID: 11384839
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Paz PE, Wang S, Clarke H, Lu X, Stokoe D, Abo A
Biochem J. 2001
PubMed ID: 11368773
Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling.
Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH
J Biol Chem. 2001
PubMed ID: 11279207
The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase.
Hauck CR, Hunter T, Schlaepfer DD
J Biol Chem. 2001
PubMed ID: 11278488
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins.
Ong SH, Hadari YR, Gotoh N, Guy GR, Schlessinger J, Lax I
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11353842
The tyrosine kinase Hck is an inhibitor of HIV-1 replication counteracted by the viral vif protein.
Hassaïne G, Courcoul M, Bessou G, Barthalay Y, Picard C, Olive D, Collette Y, Vigne R, Decroly E
J Biol Chem. 2001
PubMed ID: 11278465
Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis.
Saxton TM, Cheng AM, Ong SH, Lu Y, Sakai R, Cross JC, Pawson T
Curr Biol. 2001
PubMed ID: 11369229
Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase.
Liu Y, Jenkins B, Shin JL, Rohrschneider LR
Mol Cell Biol. 2001
PubMed ID: 11287610
Shc mediates ligand-induced internalization of epidermal growth factor receptors.
Sakaguchi K, Okabayashi Y, Kasuga M
Biochem Biophys Res Commun. 2001
PubMed ID: 11302736
Multiple effector domains within SNT1 coordinate ERK activation and neuronal differentiation of PC12 cells.
Xu H, Goldfarb M
J Biol Chem. 2001
PubMed ID: 11278583
Electroconvulsive shock increases the phosphorylation of Pyk2 in the rat hippocampus.
Jeon SH, Oh SW, Kang UG, Ahn YM, Bae CD, Park JB, Kim YS
Biochem Biophys Res Commun. 2001
PubMed ID: 11352655
Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.
Zucconi A, Dente L, Santonico E, Castagnoli L, Cesareni G
J Mol Biol. 2001
PubMed ID: 11292345
Direct binding of the signal-transducing adaptor Grb2 facilitates down-regulation of the cyclin-dependent kinase inhibitor p27Kip1.
Sugiyama Y, Tomoda K, Tanaka T, Arata Y, Yoneda-Kato N, Kato J
J Biol Chem. 2001
PubMed ID: 11278754
The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif.
Lewitzky M, Kardinal C, Gehring NH, Schmidt EK, Konkol B, Eulitz M, Birchmeier W, Schaeper U, Feller SM
Oncogene. 2001
PubMed ID: 11314042
Evidence for direct interaction between Sprouty and Cbl.
Wong ES, Lim J, Low BC, Chen Q, Guy GR
J Biol Chem. 2001
PubMed ID: 11053437
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42.
Fukuoka M, Suetsugu S, Miki H, Fukami K, Endo T, Takenawa T
J Cell Biol. 2001
PubMed ID: 11157975
Nerve growth factor signaling, neuroprotection, and neural repair.
Sofroniew MV, Howe CL, Mobley WC
Annu Rev Neurosci. 2001
PubMed ID: 11520933
Neuregulin-induced association of Sos Ras exchange protein with HER2(erbB2)/HER3(erbB3) receptor complexes in Schwann cells through a specific Grb2-HER2(erbB2) interaction.
Goodearl A, Viehover A, Vartanian T
Dev Neurosci. 2001
PubMed ID: 11173924
Disruption of T cell signaling networks and development by Grb2 haploid insufficiency.
Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, Chan AC
Nat Immunol. 2001
PubMed ID: 11135575
The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation.
Lin H, Martelli MP, Bierer BE
Int Immunol. 2001
PubMed ID: 11133830
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling.
Tsuruzoe K, Emkey R, Kriauciunas KM, Ueki K, Kahn CR
Mol Cell Biol. 2001
PubMed ID: 11113178
The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons.
Sakai R, Henderson JT, O'Bryan JP, Elia AJ, Saxton TM, Pawson T
Neuron. 2000
PubMed ID: 11163269
SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins.
Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O
Cell Signal. 2000
PubMed ID: 11152963
Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH
Mol Cell Biol. 2000
PubMed ID: 11094073
A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP.
Kato M, Miyazawa K, Kitamura N
J Biol Chem. 2000
PubMed ID: 10982817
Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src.
Suzuki A, Kadota N, Hara T, Nakagami Y, Izumi T, Takenawa T, Sabe H, Endo T
Oncogene. 2000
PubMed ID: 11127814
Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes.
Kong M, Mounier C, Wu J, Posner BI
J Biol Chem. 2000
PubMed ID: 10973965
Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes.
Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S
Biochem Biophys Res Commun. 2000
PubMed ID: 11071869
Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
Schiering N, Casale E, Caccia P, Giordano P, Battistini C
Biochemistry. 2000
PubMed ID: 11063574
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin.
Asazuma N, Wilde JI, Berlanga O, Leduc M, Leo A, Schweighoffer E, Tybulewicz V, Bon C, Liu SK, McGlade CJ, Schraven B, Watson SP
J Biol Chem. 2000
PubMed ID: 10942756
Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.
Lock LS, Royal I, Naujokas MA, Park M
J Biol Chem. 2000
PubMed ID: 10913131
Grb3-3 is up-regulated in HIV-1-infected T-cells and can potentiate cell activation through NFATc.
Li X, Multon MC, Henin Y, Schweighoffer F, Venot C, Josef J, Zhou C, LaVecchio J, Stuckert P, Raab M, Mhashilkar A, Tocque B, Marasco WA
J Biol Chem. 2000
PubMed ID: 10906142
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
p135 src homology 2 domain-containing inositol 5'-phosphatase (SHIPbeta ) isoform can substitute for p145 SHIP in fcgamma RIIB1-mediated inhibitory signaling in B cells.
March ME, Lucas DM, Aman MJ, Ravichandran KS
J Biol Chem. 2000
PubMed ID: 10900203
Specificity of the binding of synapsin I to Src homology 3 domains.
Onofri F, Giovedi S, Kao HT, Valtorta F, Bongiorno Borbone L, De Camilli P, Greengard P, Benfenati F
J Biol Chem. 2000
PubMed ID: 10899172
Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes.
Li X, Multon MC, Henin Y, Schweighoffer F, Venot C, LaVecchio J, Josef J, Stuckert P, Mhashilkar A, Tocqué B, Marasco WA
Biochem Biophys Res Commun. 2000
PubMed ID: 11006130
The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis.
Riordan SM, Lidder S, Williams R, Skouteris GG
Biochem J. 2000
PubMed ID: 10970810
Generation of novel cytoplasmic forms of protein tyrosine phosphatase epsilon by proteolytic processing and translational control.
Gil-Henn H, Volohonsky G, Toledano-Katchalski H, Gandre S, Elson A
Oncogene. 2000
PubMed ID: 10980613
Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1.
Scholler JK, Perez-Villar JJ, O'Day K, Kanner SB
Eur J Immunol. 2000
PubMed ID: 10940929
Human SPRY2 inhibits FGF2 signalling by a secreted factor.
Glienke J, Fenten G, Seemann M, Sturz A, Thierauch KH
Mech Dev. 2000
PubMed ID: 10940627
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein.
Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL
EMBO J. 2000
PubMed ID: 10921882
Characterization of the beta-dystroglycan-growth factor receptor 2 (Grb2) interaction.
Russo K, Di Stasio E, Macchia G, Rosa G, Brancaccio A, Petrucci TC
Biochem Biophys Res Commun. 2000
PubMed ID: 10903901
GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott-Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2/3) complex.
Carlier MF, Nioche P, Broutin-L'Hermite I, Boujemaa R, Le Clainche C, Egile C, Garbay C, Ducruix A, Sansonetti P, Pantaloni D
J Biol Chem. 2000
PubMed ID: 10781580
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase.
Million RP, Van Etten RA
Blood. 2000
PubMed ID: 10887132
Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein.
Lim RW, Halpain S
J Biol Chem. 2000
PubMed ID: 10781592
Overexpression of Grb2 in inflammatory lesions and preneoplastic foci and tumors induced by N-nitrosodimethylamine in Helicobacter hepaticus-infected and -noninfected A/J mice.
Diwan BA, Ramakrishna G, Anderson LM, Ramljak D
Toxicol Pathol. 2000
PubMed ID: 10930041
The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.
Velazquez L, Gish GD, van Der Geer P, Taylor L, Shulman J, Pawson T
Blood. 2000
PubMed ID: 10891441
Ligand discrimination in signaling through an ErbB4 receptor homodimer.
Sweeney C, Lai C, Riese DJ, Diamonti AJ, Cantley LC, Carraway KL
J Biol Chem. 2000
PubMed ID: 10867024
Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W
J Cell Biol. 2000
PubMed ID: 10871282
Direct binding of the signaling adapter protein Grb2 to the activation loop tyrosines on the nerve growth factor receptor tyrosine kinase, TrkA.
MacDonald JI, Gryz EA, Kubu CJ, Verdi JM, Meakin SO
J Biol Chem. 2000
PubMed ID: 10748052
CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
Poe JC, Fujimoto M, Jansen PJ, Miller AS, Tedder TF
J Biol Chem. 2000
PubMed ID: 10748054
Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk.
Ganju RK, Brubaker SA, Chernock RD, Avraham S, Groopman JE
J Biol Chem. 2000
PubMed ID: 10747947
Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral.
Rebhun JF, Chen H, Quilliam LA
J Biol Chem. 2000
PubMed ID: 10747847
Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR.
Wang X, Weng LP, Yu Q
Oncogene. 2000
PubMed ID: 10822386
BLNK is associated with the CD72/SHP-1/Grb2 complex in the WEHI231 cell line after membrane IgM cross-linking.
Fusaki N, Tomita S, Wu Y, Okamoto N, Goitsuka R, Kitamura D, Hozumi N
Eur J Immunol. 2000
PubMed ID: 10820378
The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo.
Lai KM, Pawson T
Genes Dev. 2000
PubMed ID: 10809671
FAK integrates growth-factor and integrin signals to promote cell migration.
Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD
Nat Cell Biol. 2000
PubMed ID: 10806474
Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation.
Brdicka T, Pavlistová D, Leo A, Bruyns E, Korínek V, Angelisová P, Scherer J, Shevchenko A, Hilgert I, Cerný J, Drbal K, Kuramitsu Y, Kornacker B, Horejsí V, Schraven B
J Exp Med. 2000
PubMed ID: 10790433
Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis.
Gual P, Giordano S, Williams TA, Rocchi S, Van Obberghen E, Comoglio PM
Oncogene. 2000
PubMed ID: 10734310
The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain.
Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS
EMBO J. 2000
PubMed ID: 10716926
Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines.
Brooks SR, Li X, Volanakis EJ, Carter RH
J Immunol. 2000
PubMed ID: 10706702
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.
Goldstein BJ, Bittner-Kowalczyk A, White MF, Harbeck M
J Biol Chem. 2000
PubMed ID: 10660596
A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling.
Rodrigues GA, Falasca M, Zhang Z, Ong SH, Schlessinger J
Mol Cell Biol. 2000
PubMed ID: 10648629
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.
Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ
J Biol Chem. 2000
PubMed ID: 10636929
Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain.
Delespine-Carmagnat M, Bouvier G, Bertoglio J
Eur J Immunol. 2000
PubMed ID: 10602027
High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase.
Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL
J Immunol. 1999
PubMed ID: 10570290
The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.
Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, De Camilli P
J Biol Chem. 1999
PubMed ID: 10567358
Tyrosine phosphorylation of caldesmon is required for binding to the Shc.Grb2 complex.
Wang Z, Danielsen AJ, Maihle NJ, McManus MJ
J Biol Chem. 1999
PubMed ID: 10559276
The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains.
Beard MB, O'Connell JC, Bolger GB, Houslay MD
FEBS Lett. 1999
PubMed ID: 10571082
Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.
Jones N, Master Z, Jones J, Bouchard D, Gunji Y, Sasaki H, Daly R, Alitalo K, Dumont DJ
J Biol Chem. 1999
PubMed ID: 10521483
Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M
J Biol Chem. 1999
PubMed ID: 10488157
Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling.
Park RK, Izadi KD, Deo YM, Durden DL
Blood. 1999
PubMed ID: 10477741
The transmembranal and cytoplasmic forms of protein tyrosine phosphatase epsilon physically associate with the adaptor molecule Grb2.
Toledano-Katchalski H, Elson A
Oncogene. 1999
PubMed ID: 10490839
Tyrosine phosphorylation of tub and its association with Src homology 2 domain-containing proteins implicate tub in intracellular signaling by insulin.
Kapeller R, Moriarty A, Strauss A, Stubdal H, Theriault K, Siebert E, Chickering T, Morgenstern JP, Tartaglia LA, Lillie J
J Biol Chem. 1999
PubMed ID: 10455176
Evidence for SH3 domain directed binding and phosphorylation of Sam68 by Src.
Shen Z, Batzer A, Koehler JA, Polakis P, Schlessinger J, Lydon NB, Moran MF
Oncogene. 1999
PubMed ID: 10467411
Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets.
Gross BS, Melford SK, Watson SP
Eur J Biochem. 1999
PubMed ID: 10469124
Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.
Zhao C, Yu DH, Shen R, Feng GS
J Biol Chem. 1999
PubMed ID: 10391903
Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.
Furet P, García-Echeverría C, Gay B, Schoepfer J, Zeller M, Rahuel J
J Med Chem. 1999
PubMed ID: 10395476
Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons.
Yamada M, Ohnishi H, Sano S, Araki T, Nakatani A, Ikeuchi T, Hatanaka H
J Neurochem. 1999
PubMed ID: 10386953
Identification of Tyr-703 and Tyr-936 as the primary association sites for Grb2 and Grb7 in the c-Kit/stem cell factor receptor.
Thömmes K, Lennartsson J, Carlberg M, Rönnstrand L
Biochem J. 1999
PubMed ID: 10377264
Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22.
Yohannan J, Wienands J, Coggeshall KM, Justement LB
J Biol Chem. 1999
PubMed ID: 10373493
Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I.
Hildt E, Oess S
J Exp Med. 1999
PubMed ID: 10359574
Ajuba, a novel LIM protein, interacts with Grb2, augments mitogen-activated protein kinase activity in fibroblasts, and promotes meiotic maturation of Xenopus oocytes in a Grb2- and Ras-dependent manner.
Goyal RK, Lin P, Kanungo J, Payne AS, Muslin AJ, Longmore GD
Mol Cell Biol. 1999
PubMed ID: 10330178
CMS: an adapter molecule involved in cytoskeletal rearrangements.
Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10339567
Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades.
Blaukat A, Ivankovic-Dikic I, Grönroos E, Dolfi F, Tokiwa G, Vuori K, Dikic I
J Biol Chem. 1999
PubMed ID: 10329689
NS5A, a nonstructural protein of hepatitis C virus, binds growth factor receptor-bound protein 2 adaptor protein in a Src homology 3 domain/ligand-dependent manner and perturbs mitogenic signaling.
Tan SL, Nakao H, He Y, Vijaysri S, Neddermann P, Jacobs BL, Mayer BJ, Katze MG
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10318918
Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT.
Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K
J Exp Med. 1999
PubMed ID: 10224278
16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells.
D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI
Mol Endocrinol. 1999
PubMed ID: 10319320
hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways.
Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N
Mol Cell Biol. 1999
PubMed ID: 10207103
Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells.
Tang H, Zhao ZJ, Huang XY, Landon EJ, Inagami T
J Biol Chem. 1999
PubMed ID: 10212213
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.
Meakin SO, MacDonald JI, Gryz EA, Kubu CJ, Verdi JM
J Biol Chem. 1999
PubMed ID: 10092678
Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages.
Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL
J Leukoc Biol. 1999
PubMed ID: 10204582
A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.
Wong L, Deb TB, Thompson SA, Wells A, Johnson GR
J Biol Chem. 1999
PubMed ID: 10085134
Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).
Ettmayer P, France D, Gounarides J, Jarosinski M, Martin MS, Rondeau JM, Sabio M, Topiol S, Weidmann B, Zurini M, Bair KW
J Med Chem. 1999
PubMed ID: 10090780
Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis.
Di Fruscio M, Chen T, Richard S
Proc Natl Acad Sci U S A. 1999
PubMed ID: 10077576
A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.
Lucas DM, Rohrschneider LR
Blood. 1999
PubMed ID: 10068665
Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, Atsumi T, Takahashi-Tezuka M, Ishihara K, Hibi M, Hirano T
Blood. 1999
PubMed ID: 10068651
cbl-b inhibits epidermal growth factor receptor signaling.
Ettenberg SA, Keane MM, Nau MM, Frankel M, Wang LM, Pierce JH, Lipkowitz S
Oncogene. 1999
PubMed ID: 10086340
Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.
Angers-Loustau A, Côté JF, Charest A, Dowbenko D, Spencer S, Lasky LA, Tremblay ML
J Cell Biol. 1999
PubMed ID: 10085298
Wiskott-Aldrich syndrome protein, WASP.
O'Sullivan E, Kinnon C, Brickell P
Int J Biochem Cell Biol. 1999
PubMed ID: 10224664
Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.
Zhang S, Mantel C, Broxmeyer HE
J Leukoc Biol. 1999
PubMed ID: 10080542
The gene structure of the human growth factor bound protein GRB2.
Bochmann H, Gehrisch S, Jaross W
Genomics. 1999
PubMed ID: 10051406
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
Braverman LE, Quilliam LA
J Biol Chem. 1999
PubMed ID: 10026169
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
De Sepulveda P, Okkenhaug K, Rose JL, Hawley RG, Dubreuil P, Rottapel R
EMBO J. 1999
PubMed ID: 10022833
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.
Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC
Oncogene. 1999
PubMed ID: 10022120
Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.
Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH
Mol Cell Biol. 1999
PubMed ID: 9891069
Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB.
Georgescu MM, Kirsch KH, Shishido T, Zong C, Hanafusa H
Mol Cell Biol. 1999
PubMed ID: 9891051
Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling.
Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP
Oncogene. 1999
PubMed ID: 9927207
Signaling through focal adhesion kinase.
Schlaepfer DD, Hauck CR, Sieg DJ
Prog Biophys Mol Biol. 1999
PubMed ID: 10354709
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Characterization of interactions of Nck with Sos and dynamin.
Wunderlich L, Faragó A, Buday L
Cell Signal. 1999
PubMed ID: 10206341
Waltzing with WASP.
Ramesh N, Antón IM, Martínez-Quiles N, Geha RS
Trends Cell Biol. 1999
PubMed ID: 10087612
Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
Kim B, Cheng HL, Margolis B, Feldman EL
J Biol Chem. 1998
PubMed ID: 9852124
Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc.
Liu SK, McGlade CJ
Oncogene. 1998
PubMed ID: 9872323
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.
Cheng AM, Saxton TM, Sakai R, Kulkarni S, Mbamalu G, Vogel W, Tortorice CG, Cardiff RD, Cross JC, Muller WJ, Pawson T
Cell. 1998
PubMed ID: 9865697
Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350.
Karoor V, Wang L, Wang HY, Malbon CC
J Biol Chem. 1998
PubMed ID: 9830057
Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor.
Ward AC, Monkhouse JL, Hamilton JA, Csar XF
Biochim Biophys Acta. 1998
PubMed ID: 9824671
SH3 binding domains in the dopamine D4 receptor.
Oldenhof J, Vickery R, Anafi M, Oak J, Ray A, Schoots O, Pawson T, von Zastrow M, Van Tol HH
Biochemistry. 1998
PubMed ID: 9843378
Identification and characterization of novel substrates of Trk receptors in developing neurons.
Qian X, Riccio A, Zhang Y, Ginty DD
Neuron. 1998
PubMed ID: 9856458
Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation.
Deckert M, Tartare-Deckert S, Hernandez J, Rottapel R, Altman A
Immunity. 1998
PubMed ID: 9846481
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins.
Oehrl W, Kardinal C, Ruf S, Adermann K, Groffen J, Feng GS, Blenis J, Tan TH, Feller SM
Oncogene. 1998
PubMed ID: 9788432
Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.
Sieg DJ, Ilić D, Jones KC, Damsky CH, Hunter T, Schlaepfer DD
EMBO J. 1998
PubMed ID: 9774338
SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase.
Kotani K, Wilden P, Pillay TS
Biochem J. 1998
PubMed ID: 9742218
Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor.
Pomérance M, Multon MC, Parker F, Venot C, Blondeau JP, Tocqué B, Schweighoffer F
J Biol Chem. 1998
PubMed ID: 9733714
Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules.
Ito N, Wernstedt C, Engström U, Claesson-Welsh L
J Biol Chem. 1998
PubMed ID: 9722576
SLP-76-Cbl-Grb2-Shc interactions in FcgammaRI signaling.
Chu J, Liu Y, Koretzky GA, Durden DL
Blood. 1998
PubMed ID: 9716598
ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner.
Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE
Mol Cell Biol. 1998
PubMed ID: 9710588
The SH2-containing adapter protein GRB10 interacts with BCR-ABL.
Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J
Oncogene. 1998
PubMed ID: 9747873
SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation.
Wienands J, Schweikert J, Wollscheid B, Jumaa H, Nielsen PJ, Reth M
J Exp Med. 1998
PubMed ID: 9705962
Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.
Okkenhaug K, Rottapel R
J Biol Chem. 1998
PubMed ID: 9694876
The structural basis of the activation of Ras by Sos.
Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J
Nature. 1998
PubMed ID: 9690470
A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.
Gesbert F, Guenzi C, Bertoglio J
J Biol Chem. 1998
PubMed ID: 9660791
Growth factor receptor-bound protein 2 (Grb2) association with hemopoietic specific protein 1: linkage between Lck and Grb2.
Takemoto Y, Furuta M, Sato M, Findell PR, Ramble W, Hashimoto Y
J Immunol. 1998
PubMed ID: 9670936
BLNK: a central linker protein in B cell activation.
Fu C, Turck CW, Kurosaki T, Chan AC
Immunity. 1998
PubMed ID: 9697839
Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways.
Liang Q, Mohan RR, Chen L, Wilson SE
Invest Ophthalmol Vis Sci. 1998
PubMed ID: 9660480
Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation.
Hadari YR, Kouhara H, Lax I, Schlessinger J
Mol Cell Biol. 1998
PubMed ID: 9632781
Activation of extracellular signal-regulated kinase 2 by a novel Abl-binding protein, ST5.
Majidi M, Hubbs AE, Lichy JH
J Biol Chem. 1998
PubMed ID: 9632734
Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J
J Biol Chem. 1998
PubMed ID: 9632636
Structural basis for the high affinity of amino-aromatic SH2 phosphopeptide ligands.
Rahuel J, García-Echeverría C, Furet P, Strauss A, Caravatti G, Fretz H, Schoepfer J, Gay B
J Mol Biol. 1998
PubMed ID: 9642078
The CBL-related protein CBLB participates in FLT3 and interleukin-7 receptor signal transduction in pro-B cells.
Lavagna-Sévenier C, Marchetto S, Birnbaum D, Rosnet O
J Biol Chem. 1998
PubMed ID: 9614102
Interaction between the nicotinic acetylcholine receptor and Grb2. Implications for signaling at the neuromuscular junction.
Colledge M, Froehner SC
Ann N Y Acad Sci. 1998
PubMed ID: 9668219
Human deltex is a conserved regulator of Notch signalling.
Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S
Nat Genet. 1998
PubMed ID: 9590294
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events.
Schlaepfer DD, Jones KC, Hunter T
Mol Cell Biol. 1998
PubMed ID: 9566877
Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells.
Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE
J Biol Chem. 1998
PubMed ID: 9553137
Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells.
Sakaguchi K, Okabayashi Y, Kido Y, Kimura S, Matsumura Y, Inushima K, Kasuga M
Mol Endocrinol. 1998
PubMed ID: 9544989
Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA.
Romero F, Ramos-Morales F, Domínguez A, Rios RM, Schweighoffer F, Tocqué B, Pintor-Toro JA, Fischer S, Tortolero M
J Biol Chem. 1998
PubMed ID: 9516488
Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2.
Xu XX, Yi T, Tang B, Lambeth JD
Oncogene. 1998
PubMed ID: 9569023
Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN.
Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D
J Biol Chem. 1998
PubMed ID: 9507006
Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins.
Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE
Oncogene. 1998
PubMed ID: 9484780
Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells.
Curto M, Frankel P, Carrero A, Foster DA
Biochem Biophys Res Commun. 1998
PubMed ID: 9480847
Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.
Gesbert F, Garbay C, Bertoglio J
J Biol Chem. 1998
PubMed ID: 9461587
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE
Cell. 1998
PubMed ID: 9489702
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.
Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A
J Biol Chem. 1998
PubMed ID: 9422736
The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
Warmuth M, Bergmann M, Priess A, Häuslmann K, Emmerich B, Hallek M
J Biol Chem. 1997
PubMed ID: 9407116
Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15.
Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P
FEBS Lett. 1997
PubMed ID: 9428629
An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1.
Yamaguchi A, Urano T, Goi T, Feig LA
J Biol Chem. 1997
PubMed ID: 9395447
Synaptojanin 2, a novel synaptojanin isoform with a distinct targeting domain and expression pattern.
Nemoto Y, Arribas M, Haffner C, DeCamilli P
J Biol Chem. 1997
PubMed ID: 9388224
Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases.
Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY
J Biol Chem. 1997
PubMed ID: 9374537
Growth factors stimulate tyrosine dephosphorylation of p75 and its dissociation from the SH2 domain of Grb2.
Lim YP, Low BC, Ong SH, Guy GR
J Biol Chem. 1997
PubMed ID: 9368064
Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor.
Holgado-Madruga M, Moscatello DK, Emlet DR, Dieterich R, Wong AJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9356464
A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components.
Robertson H, Langdon WY, Thien CB, Bowtell DD
Biochem Biophys Res Commun. 1997
PubMed ID: 9367879
The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck.
Bocciardi R, Mograbi B, Pasini B, Borrello MG, Pierotti MA, Bourget I, Fischer S, Romeo G, Rossi B
Oncogene. 1997
PubMed ID: 9393871
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1.
Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T
J Biol Chem. 1997
PubMed ID: 9346925
Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation.
Fu C, Chan AC
J Biol Chem. 1997
PubMed ID: 9341187
A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.
Matuoka K, Miki H, Takahashi K, Takenawa T
Biochem Biophys Res Commun. 1997
PubMed ID: 9344857
Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells.
Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O
Biochem Biophys Res Commun. 1997
PubMed ID: 9344843
Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor.
Tang J, Feng GS, Li W
Oncogene. 1997
PubMed ID: 9362449
Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling.
Bourette RP, Myles GM, Choi JL, Rohrschneider LR
EMBO J. 1997
PubMed ID: 9312046
Identification of a second Grb2 binding site in the v-Fms tyrosine kinase.
Mancini A, Niedenthal R, Joos H, Koch A, Trouliaris S, Niemann H, Tamura T
Oncogene. 1997
PubMed ID: 9380408
Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.
She HY, Rockow S, Tang J, Nishimura R, Skolnik EY, Chen M, Margolis B, Li W
Mol Biol Cell. 1997
PubMed ID: 9307968
A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2.
Pei Z, Maloney JA, Yang L, Williamson JR
Arch Biochem Biophys. 1997
PubMed ID: 9281317
Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation.
Dankort DL, Wang Z, Blackmore V, Moran MF, Muller WJ
Mol Cell Biol. 1997
PubMed ID: 9271418
Adenosine deaminase is a specific partner for the Grb2 isoform Grb3-3.
Ramos-Morales F, Domínguez A, Rios RM, Barroso SI, Infante C, Schweighoffer F, Tocqué B, Pintor-Toro JA, Tortolero M
Biochem Biophys Res Commun. 1997
PubMed ID: 9299436
Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk.
Kanda H, Mimura T, Morino N, Hamasaki K, Nakamoto T, Hirai H, Morimoto C, Yazaki Y, Nojima Y
Eur J Immunol. 1997
PubMed ID: 9295052
Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation.
Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A
Oncogene. 1997
PubMed ID: 9233773
Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.
Braunger J, Schleithoff L, Schulz AS, Kessler H, Lammers R, Ullrich A, Bartram CR, Janssen JW
Oncogene. 1997
PubMed ID: 9178760
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway.
Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J
Cell. 1997
PubMed ID: 9182757
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src.
Schlaepfer DD, Hunter T
J Biol Chem. 1997
PubMed ID: 9148935
Bcr phosphorylated on tyrosine 177 binds Grb2.
Ma G, Lu D, Wu Y, Liu J, Arlinghaus RB
Oncogene. 1997
PubMed ID: 9178913
CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2.
Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B
Oncogene. 1997
PubMed ID: 9178909
Tyrosine phosphorylation of p120cbl in BCR/abl transformed hematopoietic cells mediates enhanced association with phosphatidylinositol 3-kinase.
Jain SK, Langdon WY, Varticovski L
Oncogene. 1997
PubMed ID: 9174058
The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation.
Mainiero F, Murgia C, Wary KK, Curatola AM, Pepe A, Blumemberg M, Westwick JK, Der CJ, Giancotti FG
EMBO J. 1997
PubMed ID: 9171350
Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase.
Giordano V, De Falco G, Chiari R, Quinto I, Pelicci PG, Bartholomew L, Delmastro P, Gadina M, Scala G
J Immunol. 1997
PubMed ID: 9126968
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H
Blood. 1997
PubMed ID: 9108392
Solution structure of the Grb2 N-terminal SH3 domain complexed with a ten-residue peptide derived from SOS: direct refinement against NOEs, J-couplings and 1H and 13C chemical shifts.
Wittekind M, Mapelli C, Lee V, Goldfarb V, Friedrichs MS, Meyers CA, Mueller L
J Mol Biol. 1997
PubMed ID: 9135122
Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2.
Charest A, Wagner J, Kwan M, Tremblay ML
Oncogene. 1997
PubMed ID: 9135065
Functional importance of Shc tyrosine 317 on insulin signaling in Rat1 fibroblasts expressing insulin receptors.
Ishihara H, Sasaoka T, Ishiki M, Takata Y, Imamura T, Usui I, Langlois WJ, Sawa T, Kobayashi M
J Biol Chem. 1997
PubMed ID: 9083103
SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes.
Liu YF, Deth RC, Devys D
J Biol Chem. 1997
PubMed ID: 9079622
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain.
Su YC, Han J, Xu S, Cobb M, Skolnik EY
EMBO J. 1997
PubMed ID: 9135144
A family of proteins that inhibit signalling through tyrosine kinase receptors.
Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A
Nature. 1997
PubMed ID: 9062191
Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein.
Kanai M, Göke M, Tsunekawa S, Podolsky DK
J Biol Chem. 1997
PubMed ID: 9045692
Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J
J Biol Chem. 1997
PubMed ID: 9045636
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins.
Schlaepfer DD, Broome MA, Hunter T
Mol Cell Biol. 1997
PubMed ID: 9032297
Lck regulates Vav activation of members of the Rho family of GTPases.
Han J, Das B, Wei W, Van Aelst L, Mosteller RD, Khosravi-Far R, Westwick JK, Der CJ, Broek D
Mol Cell Biol. 1997
PubMed ID: 9032261
Signaling inositol polyphosphate-5-phosphatase. Characterization of activity and effect of GRB2 association.
Jefferson AB, Auethavekiat V, Pot DA, Williams LT, Majerus PW
J Biol Chem. 1997
PubMed ID: 9038219
The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor.
Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F
Oncogene. 1997
PubMed ID: 9050991
RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2.
Lorenzo MJ, Gish GD, Houghton C, Stonehouse TJ, Pawson T, Ponder BA, Smith DP
Oncogene. 1997
PubMed ID: 9047383
Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
Lee IS, Liu Y, Narazaki M, Hibi M, Kishimoto T, Taga T
FEBS Lett. 1997
PubMed ID: 9013873
Multiple Grb2-protein complexes in human cancer cells.
Sastry L, Cao T, King CR
Int J Cancer. 1997
PubMed ID: 9009162
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma.
Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, Wetzker R
Science. 1997
PubMed ID: 8994038
Phosphorylation of growth factor receptor binding protein-2 by pp60c-src tyrosine kinase.
Jones DA, Benjamin CW
Arch Biochem Biophys. 1997
PubMed ID: 9016807
SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.
Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA
J Biol Chem. 1997
PubMed ID: 8995445
Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases.
Yin T, Shen R, Feng GS, Yang YC
J Biol Chem. 1997
PubMed ID: 8995399
Regulatory intramolecular association in a tyrosine kinase of the Tec family.
Andreotti AH, Bunnell SC, Feng S, Berg LJ, Schreiber SL
Nature. 1997
PubMed ID: 8985255
L-selectin activates the Ras pathway via the tyrosine kinase p56lck.
Brenner B, Gulbins E, Schlottmann K, Koppenhoefer U, Busch GL, Walzog B, Steinhausen M, Coggeshall KM, Linderkamp O, Lang F
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8986819
Identification of a novel 135-kDa Grb2-binding protein in osteoclasts.
Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB
J Biol Chem. 1996
PubMed ID: 8955163
Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas).
Liu F, Hill DE, Chernoff J
J Biol Chem. 1996
PubMed ID: 8940134
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.
Bazenet CE, Gelderloos JA, Kazlauskas A
Mol Cell Biol. 1996
PubMed ID: 8943348
The Grb2-mSos1 complex binds phosphopeptides with higher affinity than Grb2.
Chook YM, Gish GD, Kay CM, Pai EF, Pawson T
J Biol Chem. 1996
PubMed ID: 8940013
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions.
van der Geer P, Wiley S, Gish GD, Pawson T
Curr Biol. 1996
PubMed ID: 8939605
A yeast three-hybrid method to clone ternary protein complex components.
Zhang J, Lautar S
Anal Biochem. 1996
PubMed ID: 8923966
STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family.
Iwama A, Yamaguchi N, Suda T
EMBO J. 1996
PubMed ID: 8918464
Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor.
Kimura T, Kihara H, Bhattacharyya S, Sakamoto H, Appella E, Siraganian RP
J Biol Chem. 1996
PubMed ID: 8910399
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development.
Maina F, Casagranda F, Audero E, Simeone A, Comoglio PM, Klein R, Ponzetto C
Cell. 1996
PubMed ID: 8898205
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Borg JP, Ooi J, Levy E, Margolis B
Mol Cell Biol. 1996
PubMed ID: 8887653
Association of a p95 Vav-containing signaling complex with the FcepsilonRI gamma chain in the RBL-2H3 mast cell line. Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex.
Song JS, Gomez J, Stancato LF, Rivera J
J Biol Chem. 1996
PubMed ID: 8900182
Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor.
Okada S, Pessin JE
J Biol Chem. 1996
PubMed ID: 8810325
Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2.
Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D
Mol Cell Biol. 1996
PubMed ID: 8816480
Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.
Schlaepfer DD, Hunter T
Mol Cell Biol. 1996
PubMed ID: 8816475
Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells.
Stein E, Cerretti DP, Daniel TO
J Biol Chem. 1996
PubMed ID: 8798570
Nuclear magnetic resonance solution structure of the growth factor receptor-bound protein 2 Src homology 2 domain.
Thornton KH, Mueller WT, McConnell P, Zhu G, Saltiel AR, Thanabal V
Biochemistry. 1996
PubMed ID: 8794768
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the COOH-terminal SH3 domain of GRB2.
Wong L, Johnson GR
J Biol Chem. 1996
PubMed ID: 8702859
Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2.
Ong SH, Goh KC, Lim YP, Low BC, Klint P, Claesson-Welsh L, Cao X, Tan YH, Guy GR
Biochem Biophys Res Commun. 1996
PubMed ID: 8780727
Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases.
Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I
Curr Biol. 1996
PubMed ID: 8805332
ATP and SH3 binding sites in the protein kinase of the large subunit of herpes simplex virus type 2 of ribonucleotide reductase (ICP10).
Nelson JW, Zhu J, Smith CC, Kulka M, Aurelian L
J Biol Chem. 1996
PubMed ID: 8663276
Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking.
Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP
Blood. 1996
PubMed ID: 8695800
Networks of interaction of p120cbl and p130cas with Crk and Grb2 adaptor proteins.
Khwaja A, Hallberg B, Warne PH, Downward J
Oncogene. 1996
PubMed ID: 8700507
Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.
den Hertog J, Hunter T
EMBO J. 1996
PubMed ID: 8670803
Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.
Fukazawa T, Miyake S, Band V, Band H
J Biol Chem. 1996
PubMed ID: 8662998
Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.
Matsuda M, Ota S, Tanimura R, Nakamura H, Matuoka K, Takenawa T, Nagashima K, Kurata T
J Biol Chem. 1996
PubMed ID: 8662907
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility.
Ponzetto C, Zhen Z, Audero E, Maina F, Bardelli A, Basile ML, Giordano S, Narsimhan R, Comoglio P
J Biol Chem. 1996
PubMed ID: 8662889
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.
Hildebrand JD, Taylor JM, Parsons JT
Mol Cell Biol. 1996
PubMed ID: 8649427
Tyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cells.
Motto DG, Musci MA, Ross SE, Koretzky GA
Mol Cell Biol. 1996
PubMed ID: 8649391
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.
Vuori K, Hirai H, Aizawa S, Ruoslahti E
Mol Cell Biol. 1996
PubMed ID: 8649368
Interaction with the phosphotyrosine binding domain/phosphotyrosine interacting domain of SHC is required for the transforming activity of the FLT4/VEGFR3 receptor tyrosine kinase.
Fournier E, Rosnet O, Marchetto S, Turck CW, Rottapel R, Pelicci PG, Birnbaum D, Borg JP
J Biol Chem. 1996
PubMed ID: 8662748
Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein.
Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M
J Biol Chem. 1996
PubMed ID: 8662733
Cloning and characterization of GRB14, a novel member of the GRB7 gene family.
Daly RJ, Sanderson GM, Janes PW, Sutherland RL
J Biol Chem. 1996
PubMed ID: 8647858
Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway.
Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J
J Biol Chem. 1996
PubMed ID: 8647802
Tyrosine phosphorylation of ACK in response to temperature shift-down, hyperosmotic shock, and epidermal growth factor stimulation.
Satoh T, Kato J, Nishida K, Kaziro Y
FEBS Lett. 1996
PubMed ID: 8647288
Tyrosine phosphorylation of a 94-kDa protein associated with GRB2/ASH is implicated in the signal transduction of hematopoietic survival factors.
Hanazono Y, Sasaki K, Odai H, Yazaki Y, Hirai H
Biochem Biophys Res Commun. 1996
PubMed ID: 8670205
Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation.
Law DA, Nannizzi-Alaimo L, Phillips DR
J Biol Chem. 1996
PubMed ID: 8631894
Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5).
Fujimoto J, Shiota M, Iwahara T, Seki N, Satoh H, Mori S, Yamamoto T
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8633037
Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors.
Smit L, van der Horst G, Borst J
J Biol Chem. 1996
PubMed ID: 8621483
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT
Curr Biol. 1996
PubMed ID: 8723348
DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.
Hasegawa H, Kiyokawa E, Tanaka S, Nagashima K, Gotoh N, Shibuya M, Kurata T, Matsuda M
Mol Cell Biol. 1996
PubMed ID: 8657152
Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route.
Barge RM, de Koning JP, Pouwels K, Dong F, Löwenberg B, Touw IP
Blood. 1996
PubMed ID: 8630373
The tyrosine phosphatase PTP1C associates with Vav, Grb2, and mSos1 in hematopoietic cells.
Kon-Kozlowski M, Pani G, Pawson T, Siminovitch KA
J Biol Chem. 1996
PubMed ID: 8632004
p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase.
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H
J Biol Chem. 1996
PubMed ID: 8621719
A Grb2-associated docking protein in EGF- and insulin-receptor signalling.
Holgado-Madruga M, Emlet DR, Moscatello DK, Godwin AK, Wong AJ
Nature. 1996
PubMed ID: 8596638
Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules.
Nunès JA, Truneh A, Olive D, Cantrell DA
J Biol Chem. 1996
PubMed ID: 8576157
Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines.
Lee JM, Fournel M, Veillette A, Branton PE
Oncogene. 1996
PubMed ID: 8570203
Novel adapter proteins that link the human GM-CSF receptor to the phosphatidylino-sitol 3-kinase and Shc/Grb2/ras signaling pathways.
Jücker M, Feldman RA
Curr Top Microbiol Immunol. 1996
PubMed ID: 8585965
Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes.
de Koning JP, Schelen AM, Dong F, van Buitenen C, Burgering BM, Bos JL, Löwenberg B, Touw IP
Blood. 1996
PubMed ID: 8547634
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase.
Fridell YW, Jin Y, Quilliam LA, Burchert A, McCloskey P, Spizz G, Varnum B, Der C, Liu ET
Mol Cell Biol. 1996
PubMed ID: 8524290
Involvement of stress-activated protein kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents.
Saleem A, Datta R, Yuan ZM, Kharbanda S, Kufe D
Cell Growth Differ. 1995
PubMed ID: 9019171
Involvement of Janus kinases in the insulin signaling pathway.
Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E
Eur J Biochem. 1995
PubMed ID: 8536716
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.
Chauhan D, Kharbanda SM, Ogata A, Urashima M, Frank D, Malik N, Kufe DW, Anderson KC
J Exp Med. 1995
PubMed ID: 7500025
Interleukin-11 induces complex formation of Grb2, Fyn, and JAK2 in 3T3L1 cells.
Wang XY, Fuhrer DK, Marshall MS, Yang YC
J Biol Chem. 1995
PubMed ID: 7499280
GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.
Huang L, Turck CW, Rao P, Peters KG
Oncogene. 1995
PubMed ID: 7478529
Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells.
Wang L, Hayashi H, Mitani Y, Ishii K, Ohnishi T, Niwa Y, Kido H, Ebina Y
Biochem Biophys Res Commun. 1995
PubMed ID: 7488107
Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor.
Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T
Biochem Biophys Res Commun. 1995
PubMed ID: 7488076
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice.
Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR
J Biol Chem. 1995
PubMed ID: 7559579
MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.
Rozakis-Adcock M, van der Geer P, Mbamalu G, Pawson T
Oncogene. 1995
PubMed ID: 7478566
The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10.
Pandey A, Duan H, Di Fiore PP, Dixit VM
J Biol Chem. 1995
PubMed ID: 7665556
Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein.
Pandey P, Kharbanda S, Kufe D
Cancer Res. 1995
PubMed ID: 7664271
Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.
Mainiero F, Pepe A, Wary KK, Spinardi L, Mohammadi M, Schlessinger J, Giancotti FG
EMBO J. 1995
PubMed ID: 7556090
Mutation at tyrosine residue 1337 abrogates ligand-dependent transforming capacity of the FLT4 receptor.
Fournier E, Dubreuil P, Birnbaum D, Borg JP
Oncogene. 1995
PubMed ID: 7675451
Constitutive phosphorylation of Shc proteins in human tumors.
Pelicci G, Lanfrancone L, Salcini AE, Romano A, Mele S, Grazia Borrello M, Segatto O, Di Fiore PP, Pelicci PG
Oncogene. 1995
PubMed ID: 7675449
A 115 kDa tyrosine phosphorylated protein associates with Grb-2 in activated Jurkat cells.
Meisner H, Czech MP
Ann N Y Acad Sci. 1995
PubMed ID: 7486658
Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding protein 2.
VanderNoot VA, Fitzpatrick FA
Anal Biochem. 1995
PubMed ID: 8585605
T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38.
Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H
J Biol Chem. 1995
PubMed ID: 7544353
Ionizing radiation stimulates a Grb2-mediated association of the stress-activated protein kinase with phosphatidylinositol 3-kinase.
Kharbanda S, Saleem A, Shafman T, Emoto Y, Taneja N, Rubin E, Weichselbaum R, Woodgett J, Avruch J, Kyriakis J
J Biol Chem. 1995
PubMed ID: 7642542
Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR.
Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB
J Biol Chem. 1995
PubMed ID: 7629168
Differential interactions of human Sos1 and Sos2 with Grb2.
Yang SS, Van Aelst L, Bar-Sagi D
J Biol Chem. 1995
PubMed ID: 7629138
The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R.
Schumacher C, Knudsen BS, Ohuchi T, Di Fiore PP, Glassman RH, Hanafusa H
J Biol Chem. 1995
PubMed ID: 7797522
Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.
Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7597091
Splicing isoforms of rat Ash/Grb2. Isolation and characterization of the cDNA and genomic DNA clones and implications for the physiological roles of the isoforms.
Watanabe K, Fukuchi T, Hosoya H, Shirasawa T, Matuoka K, Miki H, Takenawa T
J Biol Chem. 1995
PubMed ID: 7775428
Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase.
Wang J, Auger KR, Jarvis L, Shi Y, Roberts TM
J Biol Chem. 1995
PubMed ID: 7759531
SH3 domain-mediated interaction of dystroglycan and Grb2.
Yang B, Jung D, Motto D, Meyer J, Koretzky G, Campbell KP
J Biol Chem. 1995
PubMed ID: 7744812
Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes.
Saleem A, Kharbanda S, Yuan ZM, Kufe D
J Biol Chem. 1995
PubMed ID: 7737969
Insulin-stimulated disassociation of the SOS-Grb2 complex.
Waters SB, Yamauchi K, Pessin JE
Mol Cell Biol. 1995
PubMed ID: 7739560
Functional interaction between c-Src and its mitotic target, Sam 68.
Taylor SJ, Anafi M, Pawson T, Shalloway D
J Biol Chem. 1995
PubMed ID: 7537265
Crystal structure of the mammalian Grb2 adaptor.
Maignan S, Guilloteau JP, Fromage N, Arnoux B, Becquart J, Ducruix A
Science. 1995
PubMed ID: 7716522
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.
Schneider H, Cai YC, Prasad KV, Shoelson SE, Rudd CE
Eur J Immunol. 1995
PubMed ID: 7737275
Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
Jackman JK, Motto DG, Sun Q, Tanemoto M, Turck CW, Peltz GA, Koretzky GA, Findell PR
J Biol Chem. 1995
PubMed ID: 7706237
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
VanderKuur J, Allevato G, Billestrup N, Norstedt G, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7535773
Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways.
Tauchi T, Feng GS, Shen R, Hoatlin M, Bagby GC, Kabat D, Lu L, Broxmeyer HE
J Biol Chem. 1995
PubMed ID: 7534299
Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins.
Bustelo XR, Suen KL, Michael WM, Dreyfuss G, Barbacid M
Mol Cell Biol. 1995
PubMed ID: 7862126
Binding of NCK to SOS and activation of ras-dependent gene expression.
Hu Q, Milfay D, Williams LT
Mol Cell Biol. 1995
PubMed ID: 7862111
Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS.
Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE
Mol Cell Biol. 1995
PubMed ID: 7529874
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.
Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS
Mol Cell Biol. 1995
PubMed ID: 7799925
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM
J Biol Chem. 1994
PubMed ID: 7798267
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase.
Schlaepfer DD, Hanks SK, Hunter T, van der Geer P
Nature. 1994
PubMed ID: 7997267
Binding of Vav to Grb2 through dimerization of Src homology 3 domains.
Ye ZS, Baltimore D
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7809090
Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells.
Okutani T, Okabayashi Y, Kido Y, Sugimoto Y, Sakaguchi K, Matuoka K, Takenawa T, Kasuga M
J Biol Chem. 1994
PubMed ID: 7527043
p145, a major Grb2-binding protein in brain, is co-localized with dynamin in nerve terminals where it undergoes activity-dependent dephosphorylation.
McPherson PS, Takei K, Schmid SL, De Camilli P
J Biol Chem. 1994
PubMed ID: 7982917
Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.
Pajusola K, Aprelikova O, Pelicci G, Weich H, Claesson-Welsh L, Alitalo K
Oncogene. 1994
PubMed ID: 7970715
Solution structure and ligand-binding site of the carboxy-terminal SH3 domain of GRB2.
Kohda D, Terasawa H, Ichikawa S, Ogura K, Hatanaka H, Mandiyan V, Ullrich A, Schlessinger J, Inagaki F
Structure. 1994
PubMed ID: 7881903
Stimulation of glycogen synthesis by insulin in human erythroleukemia cells requires the synthesis of glycosyl-phosphatidylinositol.
Lazar DF, Knez JJ, Medof ME, Cuatrecasas P, Saltiel AR
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7524086
The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells.
Tauchi T, Feng GS, Marshall MS, Shen R, Mantel C, Pawson T, Broxmeyer HE
J Biol Chem. 1994
PubMed ID: 7523381
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.
Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG
Oncogene. 1994
PubMed ID: 8084588
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
Arvidsson AK, Rupp E, Nånberg E, Downward J, Rönnstrand L, Wennström S, Schlessinger J, Heldin CH, Claesson-Welsh L
Mol Cell Biol. 1994
PubMed ID: 7935391
5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins.
Lepley RA, Fitzpatrick FA
J Biol Chem. 1994
PubMed ID: 7929073
The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.
Donovan JA, Wange RL, Langdon WY, Samelson LE
J Biol Chem. 1994
PubMed ID: 8083187
In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.
Motto DG, Ross SE, Jackman JK, Sun Q, Olson AL, Findell PR, Koretzky GA
J Biol Chem. 1994
PubMed ID: 8063801
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
Batzer AG, Rotin D, Ureña JM, Skolnik EY, Schlessinger J
Mol Cell Biol. 1994
PubMed ID: 7518560
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
Bennett AM, Tang TL, Sugimoto S, Walsh CT, Neel BG
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8041791
Mapping GRB2, a signal transduction gene in the human and the mouse.
Yulug IG, Egan SE, See CG, Fisher EM
Genomics. 1994
PubMed ID: 7806216
Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).
Huebner K, Kastury K, Druck T, Salcini AE, Lanfrancone L, Pelicci G, Lowenstein E, Li W, Park SH, Cannizzaro L
Genomics. 1994
PubMed ID: 7806213
Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.
McPherson PS, Czernik AJ, Chilcote TJ, Onofri F, Benfenati F, Greengard P, Schlessinger J, De Camilli P
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8022809
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
den Hertog J, Tracy S, Hunter T
EMBO J. 1994
PubMed ID: 7518772
SH2 domain specificity and activity modified by a single residue.
Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T
Nature. 1994
PubMed ID: 7515480
Substrate specificities and identification of a putative binding site for PI3K in the carboxy tail of the murine Flt3 receptor tyrosine kinase.
Rottapel R, Turck CW, Casteran N, Liu X, Birnbaum D, Pawson T, Dubreuil P
Oncogene. 1994
PubMed ID: 8183574
The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins.
Borrello MG, Pelicci G, Arighi E, De Filippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA
Oncogene. 1994
PubMed ID: 8183561
Non-aligned movement support for South-South collaboration in the field of population and family planning.
Ministerial Meeting on Population of the Non-Aligned Movement (1993: Bali)
Integration. 1994
PubMed ID: 12345679
SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase.
Tauchi T, Feng GS, Shen R, Song HY, Donner D, Pawson T, Broxmeyer HE
J Biol Chem. 1994
PubMed ID: 8195176
Direct interaction between Shc and the platelet-derived growth factor beta-receptor.
Yokote K, Mori S, Hansen K, McGlade J, Pawson T, Heldin CH, Claesson-Welsh L
J Biol Chem. 1994
PubMed ID: 8195171
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I
J Biol Chem. 1994
PubMed ID: 7514169
SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.
Reif K, Buday L, Downward J, Cantrell DA
J Biol Chem. 1994
PubMed ID: 8188688
Cloning of a Grb2 isoform with apoptotic properties.
Fath I, Schweighoffer F, Rey I, Multon MC, Boiziau J, Duchesne M, Tocqué B
Science. 1994
PubMed ID: 8178156
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.
Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7512734
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.
Ren R, Ye ZS, Baltimore D
Genes Dev. 1994
PubMed ID: 7926767
Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.
Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T
Mol Cell Biol. 1994
PubMed ID: 7511210
A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells.
Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J
J Biol Chem. 1994
PubMed ID: 7510700
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.
Miki H, Miura K, Matuoka K, Nakata T, Hirokawa N, Orita S, Kaibuchi K, Takai Y, Takenawa T
J Biol Chem. 1994
PubMed ID: 8119878
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway.
Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T
EMBO J. 1994
PubMed ID: 8112292
The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.
Ravichandran KS, Burakoff SJ
J Biol Chem. 1994
PubMed ID: 8294403
Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts.
van der Geer P, Hunter T
EMBO J. 1993
PubMed ID: 8262059
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
Stern MJ, Marengere LE, Daly RJ, Lowenstein EJ, Kokel M, Batzer A, Olivier P, Pawson T, Schlessinger J
Mol Biol Cell. 1993
PubMed ID: 8305738
The GTPase dynamin binds to and is activated by a subset of SH3 domains.
Gout I, Dhand R, Hiles ID, Fry MJ, Panayotou G, Das P, Truong O, Totty NF, Hsuan J, Booker GW
Cell. 1993
PubMed ID: 8402898
Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.
Matuoka K, Shibasaki F, Shibata M, Takenawa T
EMBO J. 1993
PubMed ID: 8253073
Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
Suen KL, Bustelo XR, Pawson T, Barbacid M
Mol Cell Biol. 1993
PubMed ID: 7689150
The function of GRB2 in linking the insulin receptor to Ras signaling pathways.
Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J
Science. 1993
PubMed ID: 8316835
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D
Science. 1993
PubMed ID: 8493579
Insulin stimulates association of insulin receptor substrate-1 with the protein abundant Src homology/growth factor receptor-bound protein 2.
Tobe K, Matuoka K, Tamemoto H, Ueki K, Kaburagi Y, Asai S, Noguchi T, Matsuda M, Tanaka S, Hattori S
J Biol Chem. 1993
PubMed ID: 8388384
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.
Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J
Nature. 1993
PubMed ID: 8479541
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1.
Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D
Nature. 1993
PubMed ID: 8479540
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.
Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ, Backer JM, Ullrich A, White MF
EMBO J. 1993
PubMed ID: 8491186
Identification of a ten-amino acid proline-rich SH3 binding site.
Ren R, Mayer BJ, Cicchetti P, Baltimore D
Science. 1993
PubMed ID: 8438166
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.
Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG
Nature. 1992
PubMed ID: 1465135
Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries.
Matuoka K, Shibata M, Yamakawa A, Takenawa T
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1384039
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, Ullrich A, Skolnik EY, Bar-Sagi D, Schlessinger J
Cell. 1992
PubMed ID: 1322798
[A case of adrenal adenoma diagnosed by means of adrenal phlebography (author's transl)]
Jagielski J, Pruszyński B
Pol Przegl Radiol Med Nukl. 1977
PubMed ID: 917890

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2885	14784	81504
EnsEMBL Gene(s)	ENSG00000177885	ENSMUSG00000059923	ENSRNOG00000003990
Unigene	Hs.444356	Mm.439649	Rn.3360
Homologene	GRB2	Grb2	Grb2
OMIM	108355	N/A	N/A
GeneCards	GRB2	N/A	N/A
Beta Cell Genomics	DT.100827630 DT.100827631 DT.100827635 DT.100833847 DT.101985106 DT.455862 DT.91786336 DT.97788620	DT.101131742 DT.101301126 DT.87069284 DT.97335710	N/A
Reactome	P62993	N/A	N/A
Plasma Peptide Atlas	ENSP00000317360	N/A	N/A
WikiGenes	2885	14784	81504

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View this page in archive site

Interactor	Interactor	Sources	Classification	Pubmed IDs
GRB2	ADA	HPRD	empirical	9299436
GRB2	PDCD6IP	MINT, IntAct, BioGRID	empirical	20936779 21988832 15102471
GRB2	PDCD6	IntAct	empirical	12577067
GRB2	SH2B3	HPRD, BioGRID	empirical	8649391 8995445
GRB2	ZNF587B	IntAct	empirical	17474147
GRB2	TOM1L1	HPRD, BioGRID	empirical	11711534 12345679
GRB2	ARPC5	IntAct	empirical	12577067
GRB2	ARPC4	IntAct	empirical	12577067
GRB2	ARPC3	IntAct	empirical	12577067
GRB2	ACTR3	IntAct	empirical	12577067
GRB2	ACTR2	IntAct	empirical	12577067
GRB2	ARPC2	IntAct	empirical	12577067
GRB2	HIPK3	IntAct, BioGRID	empirical	20936779
GRB2	WASF2	HPRD	empirical	9307968
GRB2	SLC25A13	IntAct	empirical	21706016
GRB2	TNK2	HPRD, MINT, IntAct, BioGRID	empirical	8647288 16137687 20936779 11394904 20086093
GRB2	PRG4	IntAct	empirical	17474147
GRB2	HNRNPR	IntAct	empirical	17474147
GRB2	SPRY1	HPRD, MINT	empirical	12402043 16893902
GRB2	SPRY2	HPRD, MINT, BioGRID	empirical	12402043 10940627 16893902 17974561
GRB2	SF3B4	IntAct	empirical	17474147 21988832
GRB2	CDKN1B	HPRD, MINT, BioGRID	empirical	11278754 19523899
GRB2	EFS	IntAct	empirical	17474147
GRB2	TRAIP	IntAct	empirical	17474147
GRB2	DNAJA2	IntAct	empirical	12577067
GRB2	PAK4	HPRD	empirical	12529371
GRB2	TFG	IntAct, BioGRID	empirical	18624398 19380743
GRB2	TUBA1B	IntAct	empirical	12577067
GRB2	TUBB3	IntAct	empirical	12577067
GRB2	TUBB4B	IntAct	empirical	12577067
GRB2	PRMT5	IntAct	empirical	12577067
GRB2	VAV3	HPRD, MINT, IntAct, BioGRID	empirical	11094073 12577067 18654987 20936779 21706016
GRB2	TAB1	IntAct	empirical	21706016
GRB2	MERTK	HPRD	empirical	9891051
GRB2	SYNCRIP	BioGRID	empirical	9341187
GRB2	IPO7	IntAct	empirical	12577067
GRB2	DCTN2	IntAct, BioGRID	empirical	20936779
GRB2	ARPC1A	IntAct	empirical	12577067
GRB2	RPP38	IntAct	empirical	17474147