ANG

Summary Top Help

Gene Description:

angiogenin, ribonuclease A family, member 1; angiogenin, ribonuclease, RNase A family, 5

Synonyms:

Rnase5a, HEL168, AI385586, RNASE5, ANG, Ang, Ang1, RNASE4, ALS9, Rnase5

Orthologs:

Human ANG (protein-coding), Mouse Ang (protein-coding), Rat Ang1 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr14:21152336..21167130 (14.79 kb) View in Genome Browser

(Mouse) NCBIM37 - chr14:51710752..51721684 (10.93 kb) View in Genome Browser

(Rat) RGSC3.4 - chr15:27083089..27083526 (437 bp) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for ANG:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for ANG:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: None available

Reactome: None available

NCI-Nature Pathway Interaction Database: None available

Gene Ontology: 44

Publications from PubMed Top Help

Type 1 Diabetes Publications: 2

Publications: 176

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis.
van Es MA, Schelhaas HJ, van Vught PW, Ticozzi N, Andersen PM, Groen EJ, Schulte C, Blauw HM, Koppers M, Diekstra FP, Fumoto K, LeClerc AL, Keagle P, Bloem BR, Scheffer H, van Nuenen BF, van Blitterswijk M, van Rheenen W, Wills AM, Lowe PP, Hu GF, Yu W, Kishikawa H, Wu D, Folkerth RD, Mariani C, Goldwurm S, Pezzoli G, Van Damme P, Lemmens R, Dahlberg C, Birve A, Fernández-Santiago R, Waibel S, Klein C, Weber M, van der Kooi AJ, de Visser M, Verbaan D, van Hilten JJ, Heutink P, Hennekam EA, Cuppen E, Berg D, Brown RH, Silani V, Gasser T, Ludolph AC, Robberecht W, Ophoff RA, Veldink JH, Pasterkamp RJ, de Bakker PI, Landers JE, van de Warrenburg BP, van den Berg LH
Ann Neurol. 2011
PubMed ID: 22190368
Amniotic fluid angiogenin levels are decreased in pregnancies with fetal trisomy 21.
Demir A, Guclu S, Bige O, Solak A, Demir N
Prenat Diagn. 2011
PubMed ID: 21800332
SOD1 G93D sporadic amyotrophic lateral sclerosis (SALS) patient with rapid progression and concomitant novel ANG variant.
Luigetti M, Lattante S, Zollino M, Conte A, Marangi G, Del Grande A, Sabatelli M
Neurobiol Aging. 2011
PubMed ID: 21621297
Prognostic significance of the angiogenic factors angiogenin, endoglin and endostatin in cervical cancer.
Landt S, Mordelt K, Schwidde I, Barinoff J, Korlach S, Stöblen F, Lichtenegger W, Sehouli J, Kümmel S
Anticancer Res. 2011
PubMed ID: 21778318
High serum angiogenin at diagnosis predicts for failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma.
Fang S, Repo H, Joensuu H, Orpana A, Salven P
Eur J Cancer. 2011
PubMed ID: 21439815
Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM
Am J Pathol. 2011
PubMed ID: 21550017
Angiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease.
Oikonomou KA, Kapsoritakis AN, Kapsoritaki AI, Manolakis AC, Tiaka EK, Tsiopoulos FD, Tsiompanidis IA, Potamianos SP
Inflamm Bowel Dis. 2011
PubMed ID: 20629092
Kaposi's sarcoma-associated herpesvirus-induced angiogenin plays roles in latency via the phospholipase C gamma pathway: blocking angiogenin inhibits latent gene expression and induces the lytic cycle.
Sadagopan S, Valiya Veettil M, Paudel N, Bottero V, Chandran B
J Virol. 2011
PubMed ID: 21209106
Expression and localisation of vascular ribonucleases in endothelial cells.
Fischer S, Nishio M, Dadkhahi S, Gansler J, Saffarzadeh M, Shibamiyama A, Kral N, Baal N, Koyama T, Deindl E, Preissner KT
Thromb Haemost. 2011
PubMed ID: 21103661
A neuroprotective role for angiogenin in models of Parkinson's disease.
Steidinger TU, Standaert DG, Yacoubian TA
J Neurochem. 2011
PubMed ID: 21091473
Increased expression of angiogenin in nasal polyps.
Hwang KS, Park IH, Choi H, Lee SH, Lee SH, Lee HM
Am J Rhinol Allergy. 2011
PubMed ID: 21711968
Basic fibroblast growth factor affects the expression of angiogenin and cell proliferation in A375 human melanoma cells.
Zhao J, Yang Q, Yang J, Wang J, Fan L, Wang L
Tumori. 2011
PubMed ID: 21528671
MicroRNA array and microarray evaluation of endometrial receptivity in patients with high serum progesterone levels on the day of hCG administration.
Li R, Qiao J, Wang L, Li L, Zhen X, Liu P, Zheng X
Reprod Biol Endocrinol. 2011
PubMed ID: 21375772
Angiogenin in age-related macular degeneration.
Skeie JM, Zeng S, Faidley EA, Mullins RF
Mol Vis. 2011
PubMed ID: 21364907
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Angiogenin expression in head and neck basaloid and conventional squamous cell carcinoma: a site- and stage-matched comparison.
Marioni G, Staffieri A, Savastano M, Marino F, Giacomelli L, Lionello M, Casotto F, de Filippis C, Blandamura S
J Oral Pathol Med. 2011
PubMed ID: 20923443
Association of Single-Nucleotide Polymorphisms From 17 Candidate Genes With Baseline Symptom-Limited Exercise Test Duration and Decrease in Duration Over 20 Years: The Coronary Artery Risk Development in Young Adults (CARDIA) Fitness Study.
Sarzynski MA, Rankinen T, Sternfeld B, Grove ML, Fornage M, Jacobs DR, Sidney S, Bouchard C
Circ Cardiovasc Genet. 2010
PubMed ID: 20952631
Plasma haemoxygenase-1 in coronary artery disease. A comparison with angiogenin, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and vascular endothelial growth factor.
Idriss NK, Lip GY, Balakrishnan B, Jaumdally R, Boos CJ, Blann AD
Thromb Haemost. 2010
PubMed ID: 20838751
Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga A, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S
Am J Physiol Renal Physiol. 2010
PubMed ID: 20739392
Neoangiogenesis in laryngeal carcinoma: angiogenin and CD105 expression is related to carcinoma recurrence rate and disease-free survival.
Marioni G, Marino F, Blandamura S, D'Alessandro E, Giacomelli L, Guzzardo V, Lionello M, De Filippis C, Staffieri A
Histopathology. 2010
PubMed ID: 20955379
A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20673868
Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway.
Koike S, Keino-Masu K, Masu M
Biochem Biophys Res Commun. 2010
PubMed ID: 20692235
SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V
J Med Genet. 2010
PubMed ID: 20577002
Glycemic control influences serum angiogenin concentrations in patients with type 2 diabetes.
Siebert J, Reiwer-Gostomska M, Mysliwska J, Marek N, Raczynska K, Glasner L
Diabetes Care. 2010
PubMed ID: 20484129
Expression of MASPIN and angiogenin in nasopharyngeal carcinoma: novel preliminary clinico-pathological evidence.
Marioni G, Koussis H, Scola A, Maruzzo M, Giacomelli L, Karahontziti P, de Filippis C, Staffieri A, Blandamura S
Acta Otolaryngol. 2010
PubMed ID: 20105109
Human angiogenin presents neuroprotective and migration effects in neuroblastoma cells.
Cho GW, Kang BY, Kim SH
Mol Cell Biochem. 2010
PubMed ID: 20174961
FUS, TARDBP, and SOD1 mutations in a Taiwanese cohort with familial ALS.
Tsai CP, Soong BW, Lin KP, Tu PH, Lin JL, Lee YC
Neurobiol Aging. 2010
PubMed ID: 20472325
Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R
Am J Obstet Gynecol. 2010
PubMed ID: 20452482
Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation.
Fuxe J, Lashnits E, O'Brien S, Baluk P, Tabruyn SP, Kuhnert F, Kuo C, Thurston G, McDonald DM
Am J Pathol. 2010
PubMed ID: 20133818
Binding of human angiogenin inhibits actin polymerization.
Pyatibratov MG, Tolkatchev D, Plamondon J, Xu P, Ni F, Kostyukova AS
Arch Biochem Biophys. 2010
PubMed ID: 20045391
Angiopoietin-1/Tie2 signaling pathway inhibits lipopolysaccharide-induced activation of RAW264.7 macrophage cells.
Gu H, Cui M, Bai Y, Chen F, Ma K, Zhou C, Guo L
Biochem Biophys Res Commun. 2010
PubMed ID: 20060382
[Expression of angiogenin-2 and VEGF in acute leukemia and its significance].
Wang P, Ruan LH, Zhao XQ
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010
PubMed ID: 20137109
Relationship of serum angiogenin, adiponectin and resistin levels with biochemical risk factors and the angiographic severity of three-vessel coronary disease.
Kręcki R, Krzemińska-Pakuła M, Drożdż J, Szcześniak P, Peruga JZ, Lipiec P, Orszulak-Michalak D, Kasprzak JD
Cardiol J. 2010
PubMed ID: 21154263
Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.
McLaughlin RL, Phukan J, McCormack W, Lynch DS, Greenway M, Cronin S, Saunders J, Slowik A, Tomik B, Andersen PM, Bradley DG, Jakeman P, Hardiman O
PLoS One. 2010
PubMed ID: 21085671
Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily.
Kulka M, Fukuishi N, Metcalfe DD
J Leukoc Biol. 2009
PubMed ID: 19625371
Angiogenin is involved in lung adenocarcinoma cell proliferation and angiogenesis.
Yuan Y, Wang F, Liu XH, Gong DJ, Cheng HZ, Huang SD
Lung Cancer. 2009
PubMed ID: 19423182
Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.
Xie J, Wu T, Xu K, Huang IK, Cleaver O, Huang CL
Am J Pathol. 2009
PubMed ID: 19644017
Angiogenin protects motoneurons against hypoxic injury.
Sebastià J, Kieran D, Breen B, King MA, Netteland DF, Joyce D, Fitzpatrick SF, Taylor CT, Prehn JH
Cell Death Differ. 2009
PubMed ID: 19444281
Degradation by stratum corneum proteases prevents endogenous RNase inhibitor from blocking antimicrobial activities of RNase 5 and RNase 7.
Abtin A, Eckhart L, Mildner M, Ghannadan M, Harder J, Schröder JM, Tschachler E
J Invest Dermatol. 2009
PubMed ID: 19262607
Angiopoietin-1 induces neurite outgrowth of PC12 cells in a Tie2-independent, beta1-integrin-dependent manner.
Chen X, Fu W, Tung CE, Ward NL
Neurosci Res. 2009
PubMed ID: 19379779
Identification of novel Angiogenin (ANG) gene missense variants in German patients with amyotrophic lateral sclerosis.
Fernández-Santiago R, Hoenig S, Lichtner P, Sperfeld AD, Sharma M, Berg D, Weichenrieder O, Illig T, Eger K, Meyer T, Anneser J, Münch C, Zierz S, Gasser T, Ludolph A
J Neurol. 2009
PubMed ID: 19363631
Effects of basic fibroblast growth factor on angiogenin expression and cell proliferation in H7402 human hepatoma cells.
Wang J, Yang J, Yuan D, Wang J, Zhao J, Wang L
J Genet Genomics. 2009
PubMed ID: 19631914
Ribonuclease inhibitor regulates neovascularization by human angiogenin.
Dickson KA, Kang DK, Kwon YS, Kim JC, Leland PA, Kim BM, Chang SI, Raines RT
Biochemistry. 2009
PubMed ID: 19354288
Angiogenin cleaves tRNA and promotes stress-induced translational repression.
Yamasaki S, Ivanov P, Hu GF, Anderson P
J Cell Biol. 2009
PubMed ID: 19332886
Influence of basic fibroblast growth factor on the growth of HeLa cells and the expression of angiogenin.
Yang J, Wang J, Zhao J, Zuo D, Li X, Wang L
Oncol Rep. 2009
PubMed ID: 19287993
Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis.
Sadagopan S, Sharma-Walia N, Veettil MV, Bottero V, Levine R, Vart RJ, Chandran B
J Virol. 2009
PubMed ID: 19158252
Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription.
Ibaragi S, Yoshioka N, Li S, Hu MG, Hirukawa S, Sadow PM, Hu GF
Clin Cancer Res. 2009
PubMed ID: 19276260
Angiogenin-stimulated rRNA transcription is essential for initiation and survival of AKT-induced prostate intraepithelial neoplasia.
Ibaragi S, Yoshioka N, Kishikawa H, Hu JK, Sadow PM, Li M, Hu GF
Mol Cancer Res. 2009
PubMed ID: 19258415
Angiogenin is expressed in human dermal papilla cells and stimulates hair growth.
Zhou N, Fan W, Li M
Arch Dermatol Res. 2009
PubMed ID: 18936943
Stress induces tRNA cleavage by angiogenin in mammalian cells.
Fu H, Feng J, Liu Q, Sun F, Tie Y, Zhu J, Xing R, Sun Z, Zheng X
FEBS Lett. 2009
PubMed ID: 19114040
Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway.
Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, Chen F, Xiao J
Biochem Biophys Res Commun. 2009
PubMed ID: 19028450
[Genetic determinants of cardiovascular remodeling in Uzbek patients with essential hypertension]
Eliseeva MR, Srozhidinova NZ, Khamidullaeva GA, Abdullaeva GZh
Ter Arkh. 2009
PubMed ID: 19253715
Control of motoneuron survival by angiogenin.
Kieran D, Sebastia J, Greenway MJ, King MA, Connaughton D, Concannon CG, Fenner B, Hardiman O, Prehn JH
J Neurosci. 2008
PubMed ID: 19109488
Decreased expression of angiogenin in the eutopic endometrium from women with advanced stage endometriosis.
Kim SH, Choi YM, Chae HD, Kim CH, Kang BM
J Korean Med Sci. 2008
PubMed ID: 18955785
Mutations of the ANG gene in French patients with sporadic amyotrophic lateral sclerosis.
Paubel A, Violette J, Amy M, Praline J, Meininger V, Camu W, Corcia P, Andres CR, Vourc'h P, French Amyotrophic Lateral Sclerosis (ALS) Study Group
Arch Neurol. 2008
PubMed ID: 18852347
Three single nucleotide polymorphisms leading to non-synonymous amino acid substitution in the human ribonuclease 2 and angiogenin genes exhibit markedly less genetic heterogeneity in six populations.
Ueki M, Takeshita H, Fujihara J, Takatsuka H, Yuasa I, Iida R, Yasuda T
Cell Biochem Funct. 2008
PubMed ID: 18636464
Identification of new ANG gene mutations in a large cohort of Italian patients with amyotrophic lateral sclerosis.
Gellera C, Colombrita C, Ticozzi N, Castellotti B, Bragato C, Ratti A, Taroni F, Silani V
Neurogenetics. 2008
PubMed ID: 18087731
Absence of angiogenic genes modification in Italian ALS patients.
Del Bo R, Scarlato M, Ghezzi S, Martinelli-Boneschi F, Corti S, Locatelli F, Santoro D, Prelle A, Briani C, Nardini M, Siciliano G, Mancuso M, Murri L, Bresolin N, Comi GP
Neurobiol Aging. 2008
PubMed ID: 17113198
Elevated angiogenin levels in chronic heart failure.
Patel JV, Sosin M, Gunarathne A, Hussain I, Davis RC, Hughes EA, Lip GY
Ann Med. 2008
PubMed ID: 19160530
Determination of angiogenic factors in serum by protein array in patients with renal cell carcinoma.
Lukesová S, Kopecký O, Vroblová V, Hlávková D, Andrýs C, Morávek P, Cermáková E
Folia Biol (Praha). 2008
PubMed ID: 18808740
A novel Angiogenin gene mutation in a sporadic patient with amyotrophic lateral sclerosis from southern Italy.
Conforti FL, Sprovieri T, Mazzei R, Ungaro C, La Bella V, Tessitore A, Patitucci A, Magariello A, Gabriele AL, Tedeschi G, Simone IL, Majorana G, Valentino P, Condino F, Bono F, Monsurrò MR, Muglia M, Quattrone A
Neuromuscul Disord. 2008
PubMed ID: 17703939
Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis.
Wu D, Yu W, Kishikawa H, Folkerth RD, Iafrate AJ, Shen Y, Xin W, Sims K, Hu GF
Ann Neurol. 2007
PubMed ID: 17886298
Identification and characterization of follistatin as a novel angiogenin-binding protein.
Gao X, Hu H, Zhu J, Xu Z
FEBS Lett. 2007
PubMed ID: 17991437
Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis.
Crabtree B, Thiyagarajan N, Prior SH, Wilson P, Iyer S, Ferns T, Shapiro R, Brew K, Subramanian V, Acharya KR
Biochemistry. 2007
PubMed ID: 17900154
Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population.
Corrado L, Battistini S, Penco S, Bergamaschi L, Testa L, Ricci C, Giannini F, Greco G, Patrosso MC, Pileggi S, Causarano R, Mazzini L, Momigliano-Richiardi P, D'Alfonso S
J Neurol Sci. 2007
PubMed ID: 17462671
A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis.
Subramanian V, Feng Y
Hum Mol Genet. 2007
PubMed ID: 17468498
Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S
Genes Cells. 2007
PubMed ID: 17573777
Slc11a1 (Nramp1) alleles interact with acute inflammation loci to modulate wound-healing traits in mice.
De Franco M, Carneiro Pdos S, Peters LC, Vorraro F, Borrego A, Ribeiro OG, Starobinas N, Cabrera WK, Ibañez OM
Mamm Genome. 2007
PubMed ID: 17486412
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE, Vidal M
Genomics. 2007
PubMed ID: 17207965
Angiogenin-induced protein kinase B/Akt activation is necessary for angiogenesis but is independent of nuclear translocation of angiogenin in HUVE cells.
Kim HM, Kang DK, Kim HY, Kang SS, Chang SI
Biochem Biophys Res Commun. 2007
PubMed ID: 17125737
The RNase a superfamily: generation of diversity and innate host defense.
Dyer KD, Rosenberg HF
Mol Divers. 2006
PubMed ID: 16969722
Increased expression of angiogenin in gastric carcinoma in correlation with tumor angiogenesis and proliferation.
Chen Y, Zhang S, Chen YP, Lin JY
World J Gastroenterol. 2006
PubMed ID: 16937522
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.
Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO, Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS, Kim NS
Biochem Biophys Res Commun. 2006
PubMed ID: 16712791
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development.
Bäumer S, Keller L, Holtmann A, Funke R, August B, Gamp A, Wolburg H, Wolburg-Buchholz K, Deutsch U, Vestweber D
Blood. 2006
PubMed ID: 16514057
Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture.
Nakamura M, Yamabe H, Osawa H, Nakamura N, Shimada M, Kumasaka R, Murakami R, Fujita T, Osanai T, Okumura K
Nephrol Dial Transplant. 2006
PubMed ID: 16490744
Influence of angiogenin on the growth of A375 human melanoma cells and the expression of basic fibroblast growth factor.
Song J, Wang J, Yang J, Jiang C, Shen W, Wang L
Melanoma Res. 2006
PubMed ID: 16567967
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.
Greenway MJ, Andersen PM, Russ C, Ennis S, Cashman S, Donaghy C, Patterson V, Swingler R, Kieran D, Prehn J, Morrison KE, Green A, Acharya KR, Brown RH, Hardiman O
Nat Genet. 2006
PubMed ID: 16501576
Elevated expression of angiogenin in prostate cancer and its precursors.
Katona TM, Neubauer BL, Iversen PW, Zhang S, Baldridge LA, Cheng L
Clin Cancer Res. 2005
PubMed ID: 16322296
Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies.
Holloway DE, Chavali GB, Hares MC, Subramanian V, Acharya KR
Acta Crystallogr D Biol Crystallogr. 2005
PubMed ID: 16301790
A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell. 2005
PubMed ID: 16169070
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Assessment of some tools for the characterization of the human osteoarthritic cartilage proteome.
De Ceuninck F, Marcheteau E, Berger S, Caliez A, Dumont V, Raes M, Anract P, Leclerc G, Boutin JA, Ferry G
J Biomol Tech. 2005
PubMed ID: 16461950
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.
Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A
Genes Dev. 2005
PubMed ID: 16107612
Hypoxia up-regulated angiogenin and down-regulated vascular cell adhesion molecule-1 expression and secretion in human placental trophoblasts.
Rajashekhar G, Loganath A, Roy AC, Chong SS, Wong YC
J Soc Gynecol Investig. 2005
PubMed ID: 15979542
Dosage-dependent requirement for mouse Vezf1 in vascular system development.
Kuhnert F, Campagnolo L, Xiong JW, Lemons D, Fitch MJ, Zou Z, Kiosses WB, Gardner H, Stuhlmann H
Dev Biol. 2005
PubMed ID: 15882861
Alpha-actinin-2, a cytoskeletal protein, binds to angiogenin.
Hu H, Gao X, Sun Y, Zhou J, Yang M, Xu Z
Biochem Biophys Res Commun. 2005
PubMed ID: 15737636
Angiogenin is up-regulated in the nucleus and cytoplasm in human primary breast carcinoma and is associated with markers of hypoxia but not survival.
Campo L, Turley H, Han C, Pezzella F, Gatter KC, Harris AL, Fox SB
J Pathol. 2005
PubMed ID: 15776477
Dicer is required for embryonic angiogenesis during mouse development.
Yang WJ, Yang DD, Na S, Sandusky GE, Zhang Q, Zhao G
J Biol Chem. 2005
PubMed ID: 15613470
Angiogenin is translocated to the nucleus of HeLa cells and is involved in ribosomal RNA transcription and cell proliferation.
Tsuji T, Sun Y, Kishimoto K, Olson KA, Liu S, Hirukawa S, Hu GF
Cancer Res. 2005
PubMed ID: 15735021
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories.
Cho S, Beintema JJ, Zhang J
Genomics. 2005
PubMed ID: 15676279
Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model.
Ardelt AA, McCullough LD, Korach KS, Wang MM, Munzenmaier DH, Hurn PD
Stroke. 2005
PubMed ID: 15637314
Endogenous angiogenin in endothelial cells is a general requirement for cell proliferation and angiogenesis.
Kishimoto K, Liu S, Tsuji T, Olson KA, Hu GF
Oncogene. 2005
PubMed ID: 15558023
The mouse RNase 4 and RNase 5/ang 1 locus utilizes dual promoters for tissue-specific expression.
Dyer KD, Rosenberg HF
Nucleic Acids Res. 2005
PubMed ID: 15722482
Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
A novel candidate region for ALS on chromosome 14q11.2.
Greenway MJ, Alexander MD, Ennis S, Traynor BJ, Corr B, Frost E, Green A, Hardiman O
Neurology. 2004
PubMed ID: 15557516
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.
Furuyama T, Kitayama K, Shimoda Y, Ogawa M, Sone K, Yoshida-Araki K, Hisatsune H, Nishikawa S, Nakayama K, Nakayama K, Ikeda K, Motoyama N, Mori N
J Biol Chem. 2004
PubMed ID: 15184386
Elevated angiogenin levels in the peritoneal fluid of women with endometriosis correlate with the extent of the disorder.
Suzumori N, Zhao XX, Suzumori K
Fertil Steril. 2004
PubMed ID: 15236995
Serum angiogenin is not elevated in patients with early B-cell chronic lymphocytic leukemia but is prognostic factor for disease progression.
Molica S, Vitelli G, Levato D, Giannarelli D, Vacca A, Cuneo A, Ribatti D, Digiesi G
Eur J Haematol. 2004
PubMed ID: 15182336
Levels of soluble angiogenin in chronic myeloid malignancies: clinical implications.
Musolino C, Alonci A, Bellomo G, Loteta B, Quartarone E, Gangemi D, Massara E, Calabrò L
Eur J Haematol. 2004
PubMed ID: 15128420
Extra-embryonic vasculature development is regulated by the transcription factor HAND1.
Morikawa Y, Cserjesi P
Development. 2004
PubMed ID: 15073150
Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.
Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A
Int J Mol Med. 2004
PubMed ID: 15067362
Evidence for the presence of angiogenin in human testis.
Koga K, Osuga Y, Yano T, Ikezuki Y, Yoshino O, Hirota Y, Hirata T, Horie S, Ayabe T, Tsutsumi O, Taketani Y
J Androl. 2004
PubMed ID: 15064314
Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?
Han RN, Babaei S, Robb M, Lee T, Ridsdale R, Ackerley C, Post M, Stewart DJ
Circ Res. 2004
PubMed ID: 15016731
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development.
Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M
Genes Dev. 2004
PubMed ID: 15107403
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Crystallographic studies on structural features that determine the enzymatic specificity and potency of human angiogenin: Thr44, Thr80, and residues 38-41.
Holloway DE, Chavali GB, Hares MC, Baker MD, Subbarao GV, Shapiro R, Acharya KR
Biochemistry. 2004
PubMed ID: 14756559
Functional significance of Tie2 signaling in the adult vasculature.
Peters KG, Kontos CD, Lin PC, Wong AL, Rao P, Huang L, Dewhirst MW, Sankar S
Recent Prog Horm Res. 2004
PubMed ID: 14749497
The crystal structure of human angiogenin in complex with an antitumor neutralizing antibody.
Chavali GB, Papageorgiou AC, Olson KA, Fett JW, Hu G, Shapiro R, Acharya KR
Structure. 2003
PubMed ID: 12842050
Production of vascular endothelial growth factor and angiogenic factor in human follicular fluid.
Kawano Y, Zeineh Hasan K, Fukuda J, Mine S, Miyakawa I
Mol Cell Endocrinol. 2003
PubMed ID: 12770725
Angiogenin and gestational trophoblastic tumors, a promising prognostic marker.
Shaarawy M, El-Mallah SY, Sheiba M
Clin Chem Lab Med. 2003
PubMed ID: 12705339
Angiogenins: a new class of microbicidal proteins involved in innate immunity.
Hooper LV, Stappenbeck TS, Hong CV, Gordon JI
Nat Immunol. 2003
PubMed ID: 12548285
Identification and characterization of an angiogenin-binding DNA sequence that stimulates luciferase reporter gene expression.
Xu ZP, Tsuji T, Riordan JF, Hu GF
Biochemistry. 2003
PubMed ID: 12515546
Angiogenin distribution in human term placenta, and expression by cultured trophoblastic cells.
Pavlov N, Hatzi E, Bassaglia Y, Frendo JL, Evain Brion D, Badet J
Angiogenesis. 2003
PubMed ID: 15166501
Elevated serum angiogenin in multiple myeloma.
Alexandrakis MG, Passam FH, Sfiridaki A, Kyriakou DS, Petreli E, Roussou P
Hematol J. 2003
PubMed ID: 14671622
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
Serum levels of angiogenin, basic fibroblast growth factor and endostatin in patients receiving intensive chemotherapy for acute myelogenous leukemia.
Glenjen N, Mosevoll KA, Bruserud Ø
Int J Cancer. 2002
PubMed ID: 12209593
Expression and localization of angiogenin in placenta: enhanced levels at term over first trimester villi.
Rajashekhar G, Loganath A, Roy AC, Wong YC
Mol Reprod Dev. 2002
PubMed ID: 11984825
Diversifying selection of the tumor-growth promoter angiogenin in primate evolution.
Zhang J, Rosenberg HF
Mol Biol Evol. 2002
PubMed ID: 11919285
Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin.
Gho YS, Yoon WH, Chae CB
J Biol Chem. 2002
PubMed ID: 11782452
Distribution of angiogenin and its gene message in colorectal cancer patients and their clinical relevance.
Shimoyama S, Shimizu N, Tsuji E, Yamasaki K, Kawahara M, Kaminishi M
Anticancer Res. 2002
PubMed ID: 12168899
Crystallographic studies on the role of the C-terminal segment of human angiogenin in defining enzymatic potency.
Leonidas DD, Shapiro R, Subbarao GV, Russo A, Acharya KR
Biochemistry. 2002
PubMed ID: 11851402
Blood levels of angiogenin and vascular endothelial growth factor are elevated in myelodysplastic syndromes and in acute myeloid leukemia.
Brunner B, Gunsilius E, Schumacher P, Zwierzina H, Gastl G, Stauder R
J Hematother Stem Cell Res. 2002
PubMed ID: 11847008
Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.
Xu XR, Huang J, Xu ZG, Qian BZ, Zhu ZD, Yan Q, Cai T, Zhang X, Xiao HS, Qu J, Liu F, Huang QH, Cheng ZH, Li NG, Du JJ, Hu W, Shen KT, Lu G, Fu G, Zhong M, Xu SH, Gu WY, Huang W, Zhao XT, Hu GX, Gu JR, Chen Z, Han ZG
Proc Natl Acad Sci U S A. 2001
PubMed ID: 11752456
Human angiogenin fused to human CD30 ligand (Ang-CD30L) exhibits specific cytotoxicity against CD30-positive lymphoma.
Huhn M, Sasse S, Tur MK, Matthey B, Schinköthe T, Rybak SM, Barth S, Engert A
Cancer Res. 2001
PubMed ID: 11751393
Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by X-ray crystallography.
Leonidas DD, Chavali GB, Jardine AM, Li S, Shapiro R, Acharya KR
Protein Sci. 2001
PubMed ID: 11468363
Concentrations of angiogenic factors in follicular fluid and oocyte-cumulus complex culture medium from women undergoing in vitro fertilization: association with oocyte maturity and fertilization.
Malamitsi-Puchner A, Sarandakou A, Baka SG, Tziotis J, Rizos D, Hassiakos D, Creatsas G
Fertil Steril. 2001
PubMed ID: 11438326
High-level expression of three members of the murine angiogenin family in Escherichia coli and purification of the recombinant proteins.
Holloway DE, Hares MC, Shapiro R, Subramanian V, Acharya KR
Protein Expr Purif. 2001
PubMed ID: 11437607
Novel properties of the nucleolar targeting signal of human angiogenin.
Lixin R, Efthymiadis A, Henderson B, Jans DA
Biochem Biophys Res Commun. 2001
PubMed ID: 11374889
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Evidence for the presence of angiogenin in human follicular fluid and the up-regulation of its production by human chorionic gonadotropin and hypoxia.
Koga K, Osuga Y, Tsutsumi O, Momoeda M, Suenaga A, Kugu K, Fujiwara T, Takai Y, Yano T, Taketani Y
J Clin Endocrinol Metab. 2000
PubMed ID: 10999833
Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis.
Detter JC, Zhang Q, Mules EH, Novak EK, Mishra VS, Li W, McMurtrie EB, Tchernev VT, Wallace MR, Seabra MC, Swank RT, Kingsmore SF
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10737774
Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA.
Hu G, Xu C, Riordan JF
J Cell Biochem. 2000
PubMed ID: 10649442
Antitransferrin receptor antibody-RNase fusion protein expressed in the mammary gland of transgenic mice.
Newton DL, Pollock D, DiTullio P, Echelard Y, Harvey M, Wilburn B, Williams J, Hoogenboom HR, Raus JC, Meade HM, Rybak SM
J Immunol Methods. 1999
PubMed ID: 10648935
Superadditive and subadditive effects of "hot spot" mutations within the interfaces of placental ribonuclease inhibitor with angiogenin and ribonuclease A.
Chen CZ, Shapiro R
Biochemistry. 1999
PubMed ID: 10413501
Expression of receptors for human angiogenin in vascular smooth muscle cells.
Hatzi E, Badet J
Eur J Biochem. 1999
PubMed ID: 10103013
Refined crystal structures of native human angiogenin and two active site variants: implications for the unique functional properties of an enzyme involved in neovascularisation during tumour growth.
Leonidas DD, Shapiro R, Allen SC, Subbarao GV, Veluraja K, Acharya KR
J Mol Biol. 1999
PubMed ID: 9918722
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Neomycin inhibits angiogenin-induced angiogenesis.
Hu GF
Proc Natl Acad Sci U S A. 1998
PubMed ID: 9707554
Three-dimensional solution structure of human angiogenin determined by 1H,15N-NMR spectroscopy--characterization of histidine protonation states and pKa values.
Lequin O, Thüring H, Robin M, Lallemand JY
Eur J Biochem. 1997
PubMed ID: 9461294
The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis.
Apte SS, Fukai N, Beier DR, Olsen BR
J Biol Chem. 1997
PubMed ID: 9325265
Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution.
Papageorgiou AC, Shapiro R, Acharya KR
EMBO J. 1997
PubMed ID: 9311977
Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells.
Soncin F, Guitton JD, Cartwright T, Badet J
Biochem Biophys Res Commun. 1997
PubMed ID: 9245697
A putative angiogenin receptor in angiogenin-responsive human endothelial cells.
Hu GF, Riordan JF, Vallee BL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9122172
Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.
Chen CZ, Shapiro R
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9050852
Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
High-resolution genetic mapping of the gunmetal gene which regulates platelet production.
O'Brien EP, Zhen L, Jiang SY, Novak EK, Swank RT
Mamm Genome. 1996
PubMed ID: 8833241
The mouse angiogenin gene family: structures of an angiogenin-related protein gene and two pseudogenes.
Brown WE, Nobile V, Subramanian V, Shapiro R
Genomics. 1995
PubMed ID: 8530072
Identification of the nucleolar targeting signal of human angiogenin.
Moroianu J, Riordan JF
Biochem Biophys Res Commun. 1994
PubMed ID: 7945327
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease.
Acharya KR, Shapiro R, Allen SC, Riordan JF, Vallee BL
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8159679
Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity.
Moroianu J, Riordan JF
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8127865
Regional localization of loci on chromosome 14 using somatic cell hybrids.
Billingsley GD, Cox DW, Duncan AM, Goodfellow PJ, Grzeschik KH
Cytogenet Cell Genet. 1994
PubMed ID: 8275705
Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ, Svenson KL, Sparkes RS, Lusis AJ
Genomics. 1993
PubMed ID: 8288233
Characterization and sequencing of rabbit, pig and mouse angiogenins: discernment of functionally important residues and regions.
Bond MD, Strydom DJ, Vallee BL
Biochim Biophys Acta. 1993
PubMed ID: 8448182
Actin is a binding protein for angiogenin.
Hu GF, Strydom DJ, Fett JW, Riordan JF, Vallee BL
Proc Natl Acad Sci U S A. 1993
PubMed ID: 7679494
Angiogenin is a cytotoxic, tRNA-specific ribonuclease in the RNase A superfamily.
Saxena SK, Rybak SM, Davey RT, Youle RJ, Ackerman EJ
J Biol Chem. 1992
PubMed ID: 1400510
Assignment of the angiogenin gene to mouse chromosome 14 using a rapid PCR-RFLP mapping technique.
Steinhelper ME, Field LJ
Genomics. 1992
PubMed ID: 1346389
The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5.
Weremowicz S, Fox EA, Morton CC, Vallee BL
Genomics. 1990
PubMed ID: 2276743
Localization of the human angiogenin gene to chromosome band 14q11, proximal to the T cell receptor alpha/delta locus.
Weremowicz S, Fox EA, Morton CC, Vallee BL
Am J Hum Genet. 1990
PubMed ID: 1978563
Isolation and sequencing of mouse angiogenin DNA.
Bond MD, Vallee BL
Biochem Biophys Res Commun. 1990
PubMed ID: 2222458
Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis.
Shapiro R, Vallee BL
Biochemistry. 1989
PubMed ID: 2479414
Characterization of ribonucleolytic activity of angiogenin towards tRNA.
Lee FS, Vallee BL
Biochem Biophys Res Commun. 1989
PubMed ID: 2730651
Binding of placental ribonuclease inhibitor to the active site of angiogenin.
Lee FS, Vallee BL
Biochemistry. 1989
PubMed ID: 2742853
Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.
Bicknell R, Vallee BL
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2646638
Angiogenin activates endothelial cell phospholipase C.
Bicknell R, Vallee BL
Proc Natl Acad Sci U S A. 1988
PubMed ID: 2457905
Angiogenin mRNA in human tumor and normal cells.
Rybak SM, Fett JW, Yao QZ, Vallee BL
Biochem Biophys Res Commun. 1987
PubMed ID: 3619929
Isolation of angiogenin from normal human plasma.
Shapiro R, Strydom DJ, Olson KA, Vallee BL
Biochemistry. 1987
PubMed ID: 3663649
Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.
Weiner HL, Weiner LH, Swain JL
Science. 1987
PubMed ID: 2440105
Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin.
Shapiro R, Vallee BL
Proc Natl Acad Sci U S A. 1987
PubMed ID: 3470787
Characteristic ribonucleolytic activity of human angiogenin.
Shapiro R, Riordan JF, Vallee BL
Biochemistry. 1986
PubMed ID: 2424496
Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.
Kurachi K, Davie EW, Strydom DJ, Riordan JF, Vallee BL
Biochemistry. 1985
PubMed ID: 2866795
Amino acid sequence of human tumor derived angiogenin.
Strydom DJ, Fett JW, Lobb RR, Alderman EM, Bethune JL, Riordan JF, Vallee BL
Biochemistry. 1985
PubMed ID: 2866794

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	283	11727	305843
EnsEMBL Gene(s)	ENSG00000214274	ENSMUSG00000072115	ENSRNOG00000025562
Unigene	Hs.593708	Mm.202665	Rn.217453
Homologene	ANG	Ang	Ang1
OMIM	105850	N/A	N/A
GeneCards	ANG	N/A	N/A
Beta Cell Genomics	DT.101979535 DT.97763017	DT.489938	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	ENSP00000336762	N/A	N/A
WikiGenes	283	11727	305843

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Interactor	Interactor	Sources	Classification	Pubmed IDs
ANG	FST	IntAct	empirical	17991437
ANG	ATP6AP1	HPRD, IntAct	empirical	16169070
ANG	PTEN	HPRD, IntAct	empirical	16169070
ANG	RNH1	HPRD, IntAct	empirical	2742853 9311977 2276743 10413501
ANG	ABCG8	IntAct	empirical	21988832
ANG	TDGF1	HPRD, IntAct	empirical	16169070
ANG	ACTC1	HPRD	empirical	8127865
ANG	ACTN2	HPRD, IntAct	empirical	15737636
ANG	TNFSF8	HPRD	empirical	11751393