Home GHR
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Regions Overlapping this Feature:
Rat: 1
Other Regions: 1 Available
Other Regions: 1 Available
| Locus | Species | Chromosomal Location | Mb | Number of genes |
|---|---|---|---|---|
| Iddm32 | Rat | chr2:30109071..79796790 | 49.69 | 199 |
(Human) GRCh37 - chr5:42423877..42721980 (298.10 kb) View in Genome Browser
(Mouse) NCBIM37 - chr15:3267760..3533492 (265.73 kb) View in Genome Browser
(Rat) RGSC3.4 - chr2:52496517..52658066 (161.55 kb) View in Genome Browser
HaemAtlas Expression Table for GHR:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
| Human | Mouse | Rat | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
Expression Legend
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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Expression Legend
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for GHR:The GHR interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| GHR | CISH | HPRD, BioGRID, Reactome | empirical | 12586763 10585430 10551777 |
| GHR | CRK | IntAct | empirical | 17474147 |
| GHR | AP2A1 | HPRD | empirical | 10551776 |
| GHR | DUSP7 | MINT, IntAct, BioGRID | empirical | 12907755 |
| GHR | NCOA6 | HPRD, IntAct | empirical | 10567404 10866662 |
| GHR | PTPN22 | IntAct | empirical | 19167335 |
| GHR | GH1 | IntAct, BioGRID, Reactome | empirical | 8943276 9353194 7862673 17500058 2825030 |
| GHR | GH2 | HPRD, Reactome | empirical | 1955498 2825030 |
| GHR | GHR | HPRD, MIPS, Reactome | empirical | 8943276 9442080 9058373 |
| GHR | GRB2 | HPRD, IntAct, BioGRID | empirical | 9632636 17474147 |
| GHR | GRB10 | HPRD | empirical | 9632636 |
| GHR | IRS1 | HPRD | empirical | 7782332 |
| GHR | JAK1 | HPRD, BioGRID | empirical | 10502458 |
| GHR | JAK2 | HPRD, MIPS, BioGRID, Reactome | empirical | 7540178 10502458 8063815 9442080 8343952 |
| GHR | NCK1 | IntAct | empirical | 17474147 |
| GHR | PIK3R1 | HPRD, IntAct, BioGRID | empirical | 9632636 17474147 |
| GHR | PLCG1 | IntAct, BioGRID | empirical | 17474147 9632636 |
| GHR | PSAP | MINT | empirical | 12907755 |
| GHR | PTPN1 | MINT, IntAct, BioGRID | empirical | 12907755 |
| GHR | PTPN2 | HPRD, MINT, IntAct, BioGRID | empirical | 12907755 |
| GHR | PTPN3 | MINT, IntAct, BioGRID | empirical | 12907755 |
| GHR | PTPN6 | HPRD | empirical | 9632636 |
| GHR | PTPN9 | MINT, IntAct, BioGRID | empirical | 12907755 |
| GHR | PTPN11 | HPRD, MIPS, BioGRID | empirical | 10976913 9442080 9632636 |
| GHR | PTPN12 | IntAct | empirical | 19167335 |
| GHR | PTPN13 | BioGRID | empirical | 12907755 |
| GHR | PTPRB | MINT, IntAct, BioGRID | empirical | 12907755 19167335 |
| GHR | PTPRC | IntAct | empirical | 19167335 |
| GHR | PTPRH | IntAct, BioGRID | empirical | 12907755 |
| GHR | PTPRJ | IntAct | empirical | 19167335 |
| GHR | PTPRK | IntAct | empirical | 19167335 |
| GHR | SGTA | HPRD, BioGRID | empirical | 12735788 |
| GHR | SHC1 | HPRD, MINT, BioGRID | empirical | 9632636 7535773 |
| GHR | STAT3 | HPRD, BioGRID | empirical | 8923468 |
| GHR | STAT5A | HPRD | empirical | 8702683 |
| GHR | STAT5B | HPRD, BioGRID | empirical | 8923468 |
| GHR | TYK2 | HPRD, BioGRID | empirical | 10502458 |
| GHR | SOCS1 | HPRD, BioGRID, Reactome | empirical | 10585430 10551777 |
| GHR | SOCS2 | HPRD, BioGRID, Reactome | empirical | 10585430 21980433 10551777 |
| GHR | BTRC | BioGRID | empirical | 17500058 |
| GHR | SOCS3 | HPRD, BioGRID, Reactome | empirical | 10585430 10551777 |
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Type 1 Diabetes Publications: 12
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Growth hormone receptor regulates β cell hyperplasia and glucose-stimulated insulin secretion in obese mice.
Wu Y, Liu C, Sun H, Vijayakumar A, Giglou PR, Qiao R, Oppenheimer J, Yakar S, LeRoith D
J Clin Invest. 2011
PubMed ID: 21555853
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Impact of the Growth Hormone Receptor Exon 3 Deletion Gene Polymorphism on Glucose Metabolism, Lipids and IGF-I levels during puberty.
Sørensen K, Aksglaede L, Munch-Andersen T, Aachmann-Andersen NJ, Leffers H, Helge JW, Hilsted L, Juul A
J Clin Endocrinol Metab. 2009
PubMed ID: 19417039
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[Association of GHRd3 variant of growth hormone receptor gene with autoimmunity in type 1 diabetes]
García D D, Oyarzún A A, Angel B B, Carrasco P E, Pérez B F
Rev Med Chil. 2009
PubMed ID: 19701549
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Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice.
Robertson K, Kopchick JJ, Liu JL
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16621895
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The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.
Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A
Development. 2005
PubMed ID: 15930104
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Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice.
Guo Y, Lu Y, Houle D, Robertson K, Tang Z, Kopchick JJ, Liu YL, Liu JL
Endocrinology. 2005
PubMed ID: 15731363
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Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice.
Liu JL, Coschigano KT, Robertson K, Lipsett M, Guo Y, Kopchick JJ, Kumar U, Liu YL
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15138153
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Recruitment of a repressosome complex at the growth hormone receptor promoter and its potential role in diabetic nephropathy.
Gowri PM, Yu JH, Shaufl A, Sperling MA, Menon RK
Mol Cell Biol. 2003
PubMed ID: 12529387
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Identification and characterization of a novel transcript of the murine growth hormone receptor gene exhibiting development- and tissue-specific expression.
Menon RK, Shaufl A, Yu JH, Stephan DA, Friday RP
Mol Cell Endocrinol. 2001
PubMed ID: 11165047
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Changes in the growth hormone-IGF-I axis in non-obese diabetic mice.
Landau D, Segev Y, Eshet R, Flyvbjerg A, Phillip M
Int J Exp Diabetes Res. 2000
PubMed ID: 11469393
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Growth hormone receptor antagonism prevents early renal changes in nonobese diabetic mice.
Segev Y, Landau D, Rasch R, Flyvbjerg A, Phillip M
J Am Soc Nephrol. 1999
PubMed ID: 10541297
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The involvement of growth hormone-binding protein in altered GH-IGF axis in IDDM.
Kobayashi K, Amemiya S, Kobayashi K, Sawanobori E, Mochizuki M, Ishihara T, Higashida K, Miura M, Nakazawa S
Endocr J. 1999
PubMed ID: 12054124
Publications: 431
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Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.
Vijayakumar A, Wu Y, Sun H, Li X, Jeddy Z, Liu C, Schwartz GJ, Yakar S, LeRoith D
Diabetes. 2012
PubMed ID: 22187377
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Human growth hormone receptor (GHR) expression in obesity: I. GHR mRNA expression in omental and subcutaneous adipose tissues of obese women.
Erman A, Veilleux A, Tchernof A, Goodyer CG
Int J Obes (Lond). 2011
PubMed ID: 21386804
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The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects.
Derr MA, Aisenberg J, Fang P, Tenenbaum-Rakover Y, Rosenfeld RG, Hwa V
J Clin Endocrinol Metab. 2011
PubMed ID: 21900382
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Evaluation of the association between GHR exon 3 polymorphism and polycystic ovary syndrome among Han Chinese women.
Shen Y, Wang L, Zhao Y, You L, Geng L, Gu HF, Chen ZJ
Growth Horm IGF Res. 2011
PubMed ID: 21820924
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Key regulators of mitochondrial biogenesis are increased in kidneys of growth hormone receptor knockout (GHRKO) mice.
Gesing A, Bartke A, Wang F, Karbownik-Lewinska M, Masternak MM
Cell Biochem Funct. 2011
PubMed ID: 21755522
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Esterase 1 is a novel transcriptional repressor of growth hormone receptor gene expression: a unique noncatalytic role for a carboxyesterase protein.
Sun J, Kumar PA, Thimmarayappa J, Saini N, Goel P, Maures T, Lu C, Menon RK
Mol Endocrinol. 2011
PubMed ID: 21659478
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Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.
Kucia M, Shin DM, Liu R, Ratajczak J, Bryndza E, Masternak MM, Bartke A, Ratajczak MZ
Leukemia. 2011
PubMed ID: 21566652
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GH receptor plays a major role in liver regeneration through the control of EGFR and ERK1/2 activation.
Zerrad-Saadi A, Lambert-Blot M, Mitchell C, Bretes H, Collin de l'Hortet A, Baud V, Chereau F, Sotiropoulos A, Kopchick JJ, Liao L, Xu J, Gilgenkrantz H, Guidotti JE
Endocrinology. 2011
PubMed ID: 21540290
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A conditional knockout resource for the genome-wide study of mouse gene function.
Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A
Nature. 2011
PubMed ID: 21677750
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The growth hormone receptor (GHR) exon 3 polymorphism and its correlation with metabolic profiles in obese Chinese children.
Gao L, Zheng Z, Cao L, Shen S, Yang Y, Zhao Z, Zhi D, Cheng R, Pei Z, Yongfu Y, Luo F
Pediatr Diabetes. 2011
PubMed ID: 21470351
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Renal pro-apoptotic proteins are reduced by growth hormone resistance but not by visceral fat removal.
Gesing A, Bartke A, Wang F, Karbownik-Lewinska M, Masternak MM
Biol Chem. 2011
PubMed ID: 21391871
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SCF(TrCP) acts in endosomal sorting of the GH receptor.
van Kerkhof P, Westgeest M, Hassink G, Strous GJ
Exp Cell Res. 2011
PubMed ID: 21195069
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Growth hormone signaling in human T47D breast cancer cells: potential role for a growth hormone receptor-prolactin receptor complex.
Xu J, Zhang Y, Berry PA, Jiang J, Lobie PE, Langenheim JF, Chen WY, Frank SJ
Mol Endocrinol. 2011
PubMed ID: 21310852
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Higher number of stem cells in the bone marrow of circulating low Igf-1 level Laron dwarf mice--novel view on Igf-1, stem cells and aging.
Ratajczak J, Shin DM, Wan W, Liu R, Masternak MM, Piotrowska K, Wiszniewska B, Kucia M, Bartke A, Ratajczak MZ
Leukemia. 2011
PubMed ID: 21233833
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Growth hormone mediates pubertal skeletal development independent of hepatic IGF-1 production.
Courtland HW, Sun H, Beth-On M, Wu Y, Elis S, Rosen CJ, Yakar S
J Bone Miner Res. 2011
PubMed ID: 20928887
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Human growth hormone receptor gene expression is regulated by Gfi-1/1b and GAGA cis-elements.
Kenth G, Puzhko S, Goodyer CG
Mol Cell Endocrinol. 2011
PubMed ID: 21238539
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A molecular phylogeny of living primates.
Perelman P, Johnson WE, Roos C, Seuánez HN, Horvath JE, Moreira MA, Kessing B, Pontius J, Roelke M, Rumpler Y, Schneider MP, Silva A, O'Brien SJ, Pecon-Slattery J
PLoS Genet. 2011
PubMed ID: 21436896
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Regional distribution and ontogeny of the first exon variants of the rat growth hormone receptor mRNA in the brain and the pituitary gland.
Nogami H, Lee M, Soya H, Hisano S
Growth Horm IGF Res. 2011
PubMed ID: 21177131
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The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
Vesterlund M, Zadjali F, Persson T, Nielsen ML, Kessler BM, Norstedt G, Flores-Morales A
PLoS One. 2011
PubMed ID: 21980433
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Polymorphisms in the pituitary growth hormone gene and its receptor associated with coronary artery disease in a predisposed cohort from India.
Maitra A, Shanker J, Dash D, Sannappa PR, John S, Siwach P, Rao VS, Sridhara H, Kakkar VV
J Genet. 2010
PubMed ID: 21273694
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Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice.
Mavalli MD, DiGirolamo DJ, Fan Y, Riddle RC, Campbell KS, van Groen T, Frank SJ, Sperling MA, Esser KA, Bamman MM, Clemens TL
J Clin Invest. 2010
PubMed ID: 20921627
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Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer.
Gu F, Schumacher FR, Canzian F, Allen NE, Albanes D, Berg CD, Berndt SI, Boeing H, Bueno-de-Mesquita HB, Buring JE, Chabbert-Buffet N, Chanock SJ, Clavel-Chapelon F, Dumeaux V, Gaziano JM, Giovannucci EL, Haiman CA, Hankinson SE, Hayes RB, Henderson BE, Hunter DJ, Hoover RN, Johansson M, Key TJ, Khaw KT, Kolonel LN, Lagiou P, Lee IM, LeMarchand L, Lund E, Ma J, Onland-Moret NC, Overvad K, Rodriguez L, Sacerdote C, Sánchez MJ, Stampfer MJ, Stattin P, Stram DO, Thomas G, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Virtamo J, Weinstein SJ, Willett WC, Yeager M, Zhang SM, Kaaks R, Riboli E, Ziegler RG, Kraft P
Cancer Epidemiol Biomarkers Prev. 2010
PubMed ID: 20810604
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A large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ
Hum Genet. 2010
PubMed ID: 20734064
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Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.
Canzian F, Cox DG, Setiawan VW, Stram DO, Ziegler RG, Dossus L, Beckmann L, Blanché H, Barricarte A, Berg CD, Bingham S, Buring J, Buys SS, Calle EE, Chanock SJ, Clavel-Chapelon F, DeLancey JO, Diver WR, Dorronsoro M, Haiman CA, Hallmans G, Hankinson SE, Hunter DJ, Hüsing A, Isaacs C, Khaw KT, Kolonel LN, Kraft P, Le Marchand L, Lund E, Overvad K, Panico S, Peeters PH, Pollak M, Thun MJ, Tjønneland A, Trichopoulos D, Tumino R, Yeager M, Hoover RN, Riboli E, Thomas G, Henderson BE, Kaaks R, Feigelson HS
Hum Mol Genet. 2010
PubMed ID: 20634197
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
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Correlation of fl/d3 polymorphism of growth hormone receptor with the first and second year response to recombinant human growth hormone therapy in prepubertal Greek children with idiopathic isolated Growth Hormone Deficiency.
Vassiliou G, Rousso I, Katzos G, Vavatsi-Christaki N, Tzimagiorgis G
J Endocrinol Invest. 2010
PubMed ID: 20855935
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[Relationship between the polymorphism of growth hormone receptor Ex3 and the efficacy of rhGH treatment in children with idiopathic short stature].
Lu WL, Wang W, Wang DF, Xiao Y, Huang XP, Dong ZL
Zhongguo Dang Dai Er Ke Za Zhi. 2010
PubMed ID: 20849725
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The growth hormone receptor: mechanism of activation and clinical implications.
Brooks AJ, Waters MJ
Nat Rev Endocrinol. 2010
PubMed ID: 20664532
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Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: implication for regulation by IL-1beta.
Ashley RL, Henkes LE, Bouma GJ, Pru JK, Hansen TR
Endocrinology. 2010
PubMed ID: 20660068
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Influence of the d3GH receptor polymorphism on the metabolic and biochemical phenotype of GH-deficient adults at baseline and during short- and long-term recombinant human GH replacement therapy.
Giavoli C, Ferrante E, Profka E, Olgiati L, Bergamaschi S, Ronchi CL, Verrua E, Filopanti M, Passeri E, Montefusco L, Lania AG, Corbetta S, Arosio M, Ambrosi B, Spada A, Beck-Peccoz P
Eur J Endocrinol. 2010
PubMed ID: 20592127
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Associations of the growth hormone receptor (GHR) gene polymorphisms with adiposity and IGF-I activity in adolescents.
Mong JL, Ng MC, Guldan GS, Tam CH, Lee HM, Ma RC, So WY, Wong GW, Kong AP, Chan JC, Waye MM
Clin Endocrinol (Oxf). 2010
PubMed ID: 20105189
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GHR and VDR genes do not contribute to the growth hormone (GH) response in GH deficient and Turner syndrome patients.
Alvarez-Nava F, Marcano H, Pardo T, Paoli M, Gunczler P, Soto M, Villaloboss J, Lanes R
J Pediatr Endocrinol Metab. 2010
PubMed ID: 21073120
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Importance of ghrelin in hypothalamus-pituitary axis on growth hormone release during normal pregnancy in the rat.
Szczepankiewicz D, Skrzypski M, Pruszynska-Oszmalek E, Zimmermann D, Andralojc K, Kaczmarek P, Wojciechowicz T, Sassek M, Nowak KW
J Physiol Pharmacol. 2010
PubMed ID: 20814072
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A ghrelin gene variant may predict crossover rate from restricting-type anorexia nervosa to other phenotypes of eating disorders: a retrospective survival analysis.
Ando T, Komaki G, Nishimura H, Naruo T, Okabe K, Kawai K, Takii M, Oka T, Kodama N, Nakamoto C, Ishikawa T, Suzuki-Hotta M, Minatozaki K, Yamaguchi C, Nishizono-Maher A, Kono M, Kajiwara S, Suematsu H, Tomita Y, Ebana S, Okamoto Y, Nagata K, Nakai Y, Koide M, Kobayashi N, Kurokawa N, Nagata T, Kiriike N, Takenaka Y, Nagamine K, Ookuma K, Murata S, Japanese Genetic Research Group for Eating Disorders
Psychiatr Genet. 2010
PubMed ID: 20421852
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A Large-scale genetic association study of esophageal adenocarcinoma risk.
Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC
Carcinogenesis. 2010
PubMed ID: 20453000
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The exon 3 deleted growth hormone receptor gene is associated with small birth size and early pubertal onset in healthy boys.
Sørensen K, Aksglaede L, Petersen JH, Leffers H, Juul A
J Clin Endocrinol Metab. 2010
PubMed ID: 20382688
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d3-Growth hormone receptor polymorphism in acromegaly: effects on metabolic phenotype.
Montefusco L, Filopanti M, Ronchi CL, Olgiati L, La-Porta C, Losa M, Epaminonda P, Coletti F, Beck-Peccoz P, Spada A, Lania AG, Arosio M
Clin Endocrinol (Oxf). 2010
PubMed ID: 20447065
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In vivo analysis of gene expression in long-lived mice lacking the pregnancy-associated plasma protein A (PappA) gene.
Swindell WR, Masternak MM, Bartke A
Exp Gerontol. 2010
PubMed ID: 20197085
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A novel effect of growth hormone on macrophage modulates macrophage-dependent adipocyte differentiation.
Lu C, Kumar PA, Fan Y, Sperling MA, Menon RK
Endocrinology. 2010
PubMed ID: 20185763
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Rapid and high throughput genotyping of the growth hormone receptor exon 3 deleted/full-length polymorphism using a tagSNP.
Glad CA, Johannsson G, Carlsson LM, Svensson PA
Growth Horm IGF Res. 2010
PubMed ID: 20219401
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The growth hormone receptor (GHR) polymorphism in growth-retarded children with Cushing disease: lack of association with growth and measures of the somatotropic axis.
Drori-Herishanu L, Lodish M, Verma S, Bimpaki E, Keil MF, Horvath A, Stratakis CA
Horm Metab Res. 2010
PubMed ID: 20013551
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Growth hormone receptor d3-variant, insulin-like growth factor binding protein-1 -575G/A polymorphism and postnatal catch-up growth: Association with parameters of glucose homeostasis in former extremely low birth weight preterm infants.
Schreiner F, Gohlke B, Stutte S, Bartmann P, Woelfle J
Growth Horm IGF Res. 2010
PubMed ID: 20149700
-
Daily energy balance in growth hormone receptor/binding protein (GHR -/-) gene-disrupted mice is achieved through an increase in dark-phase energy efficiency.
Longo KA, Berryman DE, Kelder B, Charoenthongtrakul S, Distefano PS, Geddes BJ, Kopchick JJ
Growth Horm IGF Res. 2010
PubMed ID: 19747867
-
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.
Al-Shami A, Jhaver KG, Vogel P, Wilkins C, Humphries J, Davis JJ, Xu N, Potter DG, Gerhardt B, Mullinax R, Shirley CR, Anderson SJ, Oravecz T
PLoS One. 2010
PubMed ID: 21048919
-
[A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]
Lisitskaia KV, Krakhmaleva IN, Shishkin SS
Mol Gen Mikrobiol Virusol. 2010
PubMed ID: 20540360
-
In vivo targeting of the growth hormone receptor (GHR) Box1 sequence demonstrates that the GHR does not signal exclusively through JAK2.
Barclay JL, Kerr LM, Arthur L, Rowland JE, Nelson CN, Ishikawa M, d'Aniello EM, White M, Noakes PG, Waters MJ
Mol Endocrinol. 2010
PubMed ID: 19884384
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The exon 3-deleted growth hormone receptor is associated with better response to pegvisomant therapy in acromegaly.
Bernabeu I, Alvarez-Escolá C, Quinteiro C, Lucas T, Puig-Domingo M, Luque-Ramírez M, de Miguel-Novoa P, Fernandez-Rodriguez E, Halperin I, Loidi L, Casanueva FF, Marazuela M
J Clin Endocrinol Metab. 2010
PubMed ID: 19850678
-
Identification and characterisation of a novel GHR defect disrupting the polypyrimidine tract and resulting in GH insensitivity.
David A, Miraki-Moud F, Shaw NJ, Savage MO, Clark AJ, Metherell LA
Eur J Endocrinol. 2010
PubMed ID: 19812236
-
d3-GHR Genotype Does Not Explain Heterogeneity In GH Responsiveness In Hypopituitary Adults.
Moyes VJ, Walker DM, Owusu-Antwi S, Maher KT, Metherell L, Akker SA, Monson JP, Clark AJ, Drake WM
Clin Endocrinol (Oxf). 2009
PubMed ID: 20039885
-
Fibroblasts from long-lived mutant mice show diminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes.
Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA
Free Radic Biol Med. 2009
PubMed ID: 19786089
-
The exon-3 deleted growth hormone receptor polymorphism predisposes to long-term complications of acromegaly.
Wassenaar MJ, Biermasz NR, Pereira AM, van der Klaauw AA, Smit JW, Roelfsema F, van der Straaten T, Cazemier M, Hommes DW, Kroon HM, Kloppenburg M, Guchelaar HJ, Romijn JA
J Clin Endocrinol Metab. 2009
PubMed ID: 19864451
-
Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome.
Christiansen M
Prenat Diagn. 2009
PubMed ID: 19844941
-
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet.
Arum O, Bonkowski MS, Rocha JS, Bartke A
Aging Cell. 2009
PubMed ID: 19747233
-
Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: a potential role for growth hormone in injury-induced neurogenesis.
Christophidis LJ, Gorba T, Gustavsson M, Williams CE, Werther GA, Russo VC, Scheepens A
Growth Horm IGF Res. 2009
PubMed ID: 19524466
-
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
-
The shortness of Pygmies is associated with severe under-expression of the growth hormone receptor.
Bozzola M, Travaglino P, Marziliano N, Meazza C, Pagani S, Grasso M, Tauber M, Diegoli M, Pilotto A, Disabella E, Tarantino P, Brega A, Arbustini E
Mol Genet Metab. 2009
PubMed ID: 19541519
-
Regulation of growth hormone receptors in human prostate cancer cell lines.
Bidosee M, Karry R, Weiss-Messer E, Barkey RJ
Mol Cell Endocrinol. 2009
PubMed ID: 19540305
-
Association of the exon 3 deleted/full-length GHR polymorphism with recombinant growth hormone dose in growth hormone-deficient adults.
Meyer S, Schaefer S, Stolk L, Arp P, Uitterlinden AG, Plöckinger U, Stalla GK, Tuschy U, Weber MM, Weise A, Pfützner A, Kann PH
Pharmacogenomics. 2009
PubMed ID: 19842933
-
Further evidence for an association between mandibular height and the growth hormone receptor gene in a Japanese population.
Tomoyasu Y, Yamaguchi T, Tajima A, Nakajima T, Inoue I, Maki K
Am J Orthod Dentofacial Orthop. 2009
PubMed ID: 19815155
-
The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy.
Adetunji OR, MacFarlane IA, Javadpour M, Alfirevic A, Pirmohamed M, Blair JC
Eur J Endocrinol. 2009
PubMed ID: 19605543
-
Impact of the exon 3-deleted growth hormone (GH) receptor polymorphism on baseline height and the growth response to recombinant human GH therapy in GH-deficient (GHD) and non-GHD children with short stature: a systematic review and meta-analysis.
Wassenaar MJ, Dekkers OM, Pereira AM, Wit JM, Smit JW, Biermasz NR, Romijn JA
J Clin Endocrinol Metab. 2009
PubMed ID: 19584188
-
The P561T polymorphism of the growth hormone receptor gene has an inhibitory effect on mandibular growth in young children.
Sasaki Y, Satoh K, Hayasaki H, Fukumoto S, Fujiwara T, Nonaka K
Eur J Orthod. 2009
PubMed ID: 19447840
-
The cardiovascular phenotype of a mouse model of acromegaly.
Izzard AS, Emerson M, Prehar S, Neyses L, Trainer P, List EO, Kopchick JJ, Heagerty AM
Growth Horm IGF Res. 2009
PubMed ID: 19269870
-
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M
PLoS Genet. 2009
PubMed ID: 19730683
-
Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.
Guey LT, García-Closas M, Murta-Nascimento C, Lloreta J, Palencia L, Kogevinas M, Rothman N, Vellalta G, Calle ML, Marenne G, Tardón A, Carrato A, García-Closas R, Serra C, Silverman DT, Chanock S, Real FX, Malats N, for the EPICURO/Spanish Bladder Cancer Study investigators
Eur Urol. 2009
PubMed ID: 19692168
-
The common exon 3 polymorphism of the growth hormone receptor (GHR) gene and the effect of growth hormone therapy on growth in Korean patients with Turner syndrome.
Ko JM, Kim JM, Cheon CK, Kim DH, Lee DY, Cheong WY, Kim EY, Park MJ, Yoo HW
Clin Endocrinol (Oxf). 2009
PubMed ID: 19681916
-
D3 GH receptor polymorphism is not associated with IGF1 levels in untreated acromegaly.
Kamenicky P, Dos Santos C, Espinosa C, Salenave S, Galland F, Le Bouc Y, Maison P, Bougnères P, Chanson P
Eur J Endocrinol. 2009
PubMed ID: 19439509
-
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism.
Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA
J Biol Chem. 2009
PubMed ID: 19460757
-
PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Hosgood HD, Menashe I, He X, Chanock S, Lan Q
Respir Med. 2009
PubMed ID: 19625176
-
A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study.
Dennison EM, Syddall HE, Jameson KA, Sayer AA, Gaunt TR, Rodriguez S, Day IN, Cooper C, Lips MA, Hertfordshire Cohort Study Group
J Rheumatol. 2009
PubMed ID: 19487270
-
Adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes.
Yang Y, Wu Z, Zhao T, Wang H, Zhao D, Zhang J, Wang Y, Ding Y, Qiu G
Orthopedics. 2009
PubMed ID: 19634821
-
Association of the growth hormone receptor gene polymorphisms with mandibular height in a Korean population.
Kang EH, Yamaguchi T, Tajima A, Nakajima T, Tomoyasu Y, Watanabe M, Yamaguchi M, Park SB, Maki K, Inoue I
Arch Oral Biol. 2009
PubMed ID: 19344888
-
Influence of growth hormone receptor d3 and full-length isoforms on biochemical treatment outcomes in acromegaly.
Bianchi A, Giustina A, Cimino V, Pola R, Angelini F, Pontecorvi A, De Marinis L
J Clin Endocrinol Metab. 2009
PubMed ID: 19336510
-
Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients.
O R A, J C B, M J, A A, M P, I A M
Clin Endocrinol (Oxf). 2009
PubMed ID: 19486024
-
A High-Density Association Study of 383 Candidate Genes for Volumetric Bone Density at the Femoral Neck and Lumbar Spine among Older Men.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, for the MrOS Research Group
J Bone Miner Res. 2009
PubMed ID: 19453261
-
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
-
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.
Shen M, Vermeulen R, Rajaraman P, Menashe I, He X, Chapman RS, Yeager M, Thomas G, Burdett L, Hutchinson A, Yuenger J, Chanock S, Lan Q
Environ Mol Mutagen. 2009
PubMed ID: 19170196
-
Growth hormone receptor exon 3 isoforms and their implication in growth disorders and treatment.
Jorge AA, Arnhold IJ
Horm Res. 2009
PubMed ID: 19407498
-
Structure and activity of the human growth hormone receptor (hGHR) gene V2 promoter.
Wei Y, Puzhko S, Wabitsch M, Goodyer CG
Mol Endocrinol. 2009
PubMed ID: 19116246
-
Transcriptional regulation of the human growth hormone receptor (hGHR) gene V2 promoter by transcriptional activators and repressor.
Wei Y, Puzhko S, Wabitsch M, Goodyer CG
Mol Endocrinol. 2009
PubMed ID: 19116245
-
Accelerated failure time models provide a useful statistical framework for aging research.
Swindell WR
Exp Gerontol. 2009
PubMed ID: 19007875
-
Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma.
Brunet-Dunand SE, Vouyovitch C, Araneda S, Pandey V, Vidal LJ, Print C, Mertani HC, Lobie PE, Perry JK
Endocrinology. 2009
PubMed ID: 18974274
-
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage CA, Huot L, Bensemain F, Laumet G, Ayral AM, Fievet N, Hauw JJ, Dekosky ST, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues JF, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh MI, Amouyel P, Lambert JC
Mol Psychiatry. 2009
PubMed ID: 19204726
-
Influence of the exon 3-deleted/full-length growth hormone (GH) receptor polymorphism on the response to GH replacement therapy in adults with severe GH deficiency.
Barbosa EJ, Palming J, Glad CA, Filipsson H, Koranyi J, Bengtsson BA, Carlsson LM, Boguszewski CL, Johannsson G
J Clin Endocrinol Metab. 2009
PubMed ID: 19050057
-
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell. 2009
PubMed ID: 19167335
-
Difference between Japanese and Caucasian populations in the allelic frequency of growth hormone receptor polymorphisms.
Iida K, Takahashi Y, Kaji H, Okimura Y, Nose O, Chihara K
J Pediatr Endocrinol Metab. 2009
PubMed ID: 19344073
-
Disruption of growth hormone receptor prevents calorie restriction from improving insulin action and longevity.
Bonkowski MS, Dominici FP, Arum O, Rocha JS, Al Regaiey KA, Westbrook R, Spong A, Panici J, Masternak MM, Kopchick JJ, Bartke A
PLoS One. 2009
PubMed ID: 19234595
-
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
Benyamin B, McRae AF, Zhu G, Gordon S, Henders AK, Palotie A, Peltonen L, Martin NG, Montgomery GW, Whitfield JB, Visscher PM
Am J Hum Genet. 2009
PubMed ID: 19084217
-
Does adiposity status influence femoral cortical strength in rodent models of growth hormone deficiency?
Stevenson AE, Evans BA, Gevers EF, Elford C, McLeod RW, Perry MJ, El-Kasti MM, Coschigano KT, Kopchick JJ, Evans SL, Wells T
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19001545
-
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status.
Song Z, Ju Z, Rudolph KL
Exp Gerontol. 2009
PubMed ID: 18640258
-
Growth hormone receptor polymorphism and the effects of pegvisomant in acromegaly.
Bianchi A, Mazziotti G, Tilaro L, Cimino V, Veltri F, Gaetani E, Pecorini G, Pontecorvi A, Giustina A, De Marinis L
Pituitary. 2008
PubMed ID: 19089622
-
E180splice mutation in the growth hormone receptor gene in a Chilean family with growth hormone insensitivity: a probable common Mediterranean ancestor.
Espinosa C, Sjoberg M, Salazar T, Rodriguez A, Cassorla FG, Mericq MV, Carvallo P
J Pediatr Endocrinol Metab. 2008
PubMed ID: 19189684
-
Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women.
Palmieri RT, Wilson MA, Iversen ES, Clyde MA, Calingaert B, Moorman PG, Poole C, Anderson AR, Anderson S, Anton-Culver H, Beesley J, Hogdall E, Brewster W, Carney ME, Chen X, Chenevix-Trench G, Chang-Claude J, Cunningham JM, Dicioccio RA, Doherty JA, Easton DF, Edlund CK, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Kjaer SK, Hogdall CK, Hopkins MP, Jenison EL, Blaakaer J, Lurie G, McGuire V, Menon U, Moysich KB, Ness RB, Pearce CL, Pharoah PD, Pike MC, Ramus SJ, Rossing MA, Song H, Terada KY, Vandenberg D, Vierkant RA, Wang-Gohrke S, Webb PM, Whittemore AS, Wu AH, Ziogas A, Berchuck A, Schildkraut JM, Ovarian Cancer Association Consortium, Australian Cancer Study (Ovarian Cancer Group), Australian Ovarian Cancer Study Group
Cancer Epidemiol Biomarkers Prev. 2008
PubMed ID: 19064572
-
Lack of an association between GHR exon 3 polymorphism and diabetic nephropathy in the Genetics of Kidneys in Diabetes (GoKinD) population.
Gu HF, Efendic S, Brismar K
Diabetologia. 2008
PubMed ID: 18820897
-
[Novel nonsense mutation (p.Y113X) in the human growth hormone receptor gene in a Brazilian patient with Laron syndrome].
Diniz ET, Jorge AA, Arnhold IJ, Rosenbloom AL, Bandeira F
Arq Bras Endocrinol Metabol. 2008
PubMed ID: 19169479
-
Growth hormone (GH1) gene variation and the growth hormone receptor (GHR) exon 3 deletion polymorphism in a West-African population.
Millar DS, Lewis MD, Horan M, Newsway V, Rees DA, Easter TE, Pepe G, Rickards O, Norin M, Scanlon MF, Krawczak M, Cooper DN
Mol Cell Endocrinol. 2008
PubMed ID: 18950677
-
Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old.
Dehari R, Nakamura Y, Okamoto N, Nakayama H
Tohoku J Exp Med. 2008
PubMed ID: 18832799
-
Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.
Hosgood HD, Menashe I, Shen M, Yeager M, Yuenger J, Rajaraman P, He X, Chatterjee N, Caporaso NE, Zhu Y, Chanock SJ, Zheng T, Lan Q
Carcinogenesis. 2008
PubMed ID: 18676680
-
Growth hormone and its receptor in human ovaries from fetuses and adults.
Abir R, Garor R, Felz C, Nitke S, Krissi H, Fisch B
Fertil Steril. 2008
PubMed ID: 18054353
-
The common exon 3 polymorphism of the growth hormone receptor (GHR) gene and effect of growth hormone therapy on growth in Korean children with idiopathic short stature.
Ko JM, Park JY, Yoo HW
Clin Endocrinol (Oxf). 2008
PubMed ID: 18793346
-
Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.
Tatarakis A, Margaritis T, Martinez-Jimenez CP, Kouskouti A, Mohan WS, Haroniti A, Kafetzopoulos D, Tora L, Talianidis I
Mol Cell. 2008
PubMed ID: 18722179
-
Clinical and Biochemical impact of the d3 (fl) Growth Hormone Receptor genotype in Acromegaly.
Mercado M, González B, Sandoval C, Esquenazi Y, Mier F, Vargas G, Espinosa de Los Monteros AL, Sosa E
J Clin Endocrinol Metab. 2008
PubMed ID: 18611972
-
Developmental changes in the human GH receptor and its signal transduction pathways.
Kenth G, Mergelas JA, Goodyer CG
J Endocrinol. 2008
PubMed ID: 18420710
-
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway.
Rowlinson SW, Yoshizato H, Barclay JL, Brooks AJ, Behncken SN, Kerr LM, Millard K, Palethorpe K, Nielsen K, Clyde-Smith J, Hancock JF, Waters MJ
Nat Cell Biol. 2008
PubMed ID: 18488018
-
Endotoxin-induced proteolytic reduction in hepatic growth hormone (GH) receptor: a novel mechanism for GH insensitivity.
Wang X, Jiang J, Warram J, Baumann G, Gan Y, Menon RK, Denson LA, Zinn KR, Frank SJ
Mol Endocrinol. 2008
PubMed ID: 18323468
-
GH receptor d3 polymorphism in Dutch patients with MPHD and IGHD born small or appropriate for gestational age.
de Graaff LC, Meyer S, Els C, Hokken-Koelega AC
Clin Endocrinol (Oxf). 2008
PubMed ID: 18031312
-
The exon 3-deleted/full-length growth hormone receptor polymorphism does not influence the effect of puberty or growth hormone therapy on glucose homeostasis in short non-growth hormone-deficient small-for-gestational-age children: results from a two-year
Audí L, Carrascosa A, Esteban C, Fernández-Cancio M, Andaluz P, Yeste D, Espadero R, Granada ML, Wollmann H, Fryklund L, the Spanish SGA Study Group
J Clin Endocrinol Metab. 2008
PubMed ID: 18445665
-
Influence of the d3-growth hormone receptor isoform on short-term and long-term treatment response to growth hormone replacement in growth hormone deficient adults.
van der Klaauw AA, van der Straaten T, Baak-Pablo R, Biermasz NR, Guchelaar HJ, Pereira AM, Smit JW, Romijn JA
J Clin Endocrinol Metab. 2008
PubMed ID: 18397980
-
Lung cancer risk associated with Thr495Pro polymorphism of GHR in Chinese population.
Cao G, Lu H, Feng J, Shu J, Zheng D, Hou Y
Jpn J Clin Oncol. 2008
PubMed ID: 18299312
-
Homozygosity of the d3-growth hormone receptor polymorphism is associated with a high total effect of GH on growth and a low BMI in girls with Turner syndrome.
Binder G, Trebar B, Baur F, Schweizer R, Ranke MB
Clin Endocrinol (Oxf). 2008
PubMed ID: 17973940
-
Relative cardiac expression of growth hormone receptor and insulin-like growth factor-I mRNA in congenital heart disease.
Nygren A, Sunnegårdh J, Albertsson-Wikland K, Berggren H, Isgaard J
J Endocrinol Invest. 2008
PubMed ID: 18401200
-
The exon 3-deleted/full-length growth hormone receptor polymorphism did not influence growth response to growth hormone therapy over two years in prepubertal short children born at term with adequate weight and length for gestational age.
Carrascosa A, Audí L, Fernández-Cancio M, Esteban C, Andaluz P, Vilaró E, Clemente M, Yeste D, Albisu MA, Gussinyé M
J Clin Endocrinol Metab. 2008
PubMed ID: 18160465
-
Growth hormone (GH) insensitivity and insulin-like growth factor-I deficiency in Inuit subjects and an Ecuadorian cohort: functional studies of two codon 180 GH receptor gene mutations.
Fang P, Girgis R, Little BM, Pratt KL, Guevara-Aguirre J, Hwa V, Rosenfeld RG
J Clin Endocrinol Metab. 2008
PubMed ID: 18073295
-
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
Hom G, Graham RR, Modrek B, Taylor KE, Ortmann W, Garnier S, Lee AT, Chung SA, Ferreira RC, Pant PV, Ballinger DG, Kosoy R, Demirci FY, Kamboh MI, Kao AH, Tian C, Gunnarsson I, Bengtsson AA, Rantapää-Dahlqvist S, Petri M, Manzi S, Seldin MF, Rönnblom L, Syvänen AC, Criswell LA, Gregersen PK, Behrens TW
N Engl J Med. 2008
PubMed ID: 18204098
-
Expression of the hepatic specific V1 messenger ribonucleic acid of the human growth hormone receptor gene is regulated by hepatic nuclear factor (HNF)-4alpha2 and HNF-4alpha8.
Goodyer CG, Rhani Z, Zheng H
Mol Endocrinol. 2008
PubMed ID: 17991764
-
Polymorphisms of the Ghrelin/Obestatin gene and ghrelin levels in Chinese children with short stature.
Zou CC, Huang K, Liang L, Zhao ZY
Clin Endocrinol (Oxf). 2008
PubMed ID: 18182091
-
Altered metabolism of growth hormone receptor mutant mice: a combined NMR metabonomics and microarray study.
Schirra HJ, Anderson CG, Wilson WJ, Kerr L, Craik DJ, Waters MJ, Lichanska AM
PLoS ONE. 2008
PubMed ID: 18648510
-
Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, Agana L, Becker N, Tressler P, Forrest MS, Sankararaman S, Conde L, Holly EA, Smith MT
PLoS ONE. 2008
PubMed ID: 18636124
-
Novel splice site mutation in the growth hormone receptor gene in Turkish patients with Laron-type dwarfism.
Arman A, Ozon A, Isguven PS, Coker A, Peker I, Yordam N
J Pediatr Endocrinol Metab. 2008
PubMed ID: 18404972
-
Growth hormone (GH) dose, but not exon 3-deleted/full-length GH receptor polymorphism genotypes, influences growth response to two-year GH Therapy in Short Small-for-Gestational-Age Children.
Carrascosa A, Audí L, Esteban C, Fernández-Cancio M, Andaluz P, Gussinyé M, Clemente M, Yeste D, Albisu MA
J Clin Endocrinol Metab. 2008
PubMed ID: 17925340
-
Growth Hormone (GH) receptor C.1319 G>T polymorphism, but not exon 3 retention or deletion is associated with better first-year growth response to GH therapy in patients with GH deficiency.
Wan L, Chen WC, Tsai Y, Kao YT, Hsieh YY, Lee CC, Tsai CH, Chen CP, Tsai FJ
Pediatr Res. 2007
PubMed ID: 17957148
-
Growth hormone receptor expression is up-regulated during tumorigenesis of human colorectal cancer.
Wu X, Liu F, Yao X, Li W, Chen C
J Surg Res. 2007
PubMed ID: 17764692
-
Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells.
Loesch K, Deng L, Wang X, He K, Jiang J, Frank SJ
Endocrinology. 2007
PubMed ID: 17761766
-
Association of the growth hormone receptor d3-variant and catch-up growth of preterm infants with birth weight of less than 1500 grams.
Schreiner F, Stutte S, Bartmann P, Gohlke B, Woelfle J
J Clin Endocrinol Metab. 2007
PubMed ID: 17711923
-
Mammalian protein-protein interaction trap (MAPPIT) analysis of STAT5, CIS, and SOCS2 interactions with the growth hormone receptor.
Uyttendaele I, Lemmens I, Verhee A, De Smet AS, Vandekerckhove J, Lavens D, Peelman F, Tavernier J
Mol Endocrinol. 2007
PubMed ID: 17666591
-
Insulin regulation of growth hormone receptor gene expression: involvement of both the PI-3 kinase and MEK/ERK signaling pathways.
Bennett WL, Keeton AB, Ji S, Xu J, Messina JL
Endocrine. 2007
PubMed ID: 18040895
-
Growth hormone binding protein levels in children are associated with birth weight, postnatal weight gain, and insulin secretion.
Ong KK, Elmlinger M, Jones R, Emmett P, ALSPAC Study Team, Holly J, Ranke MB, Dunger DB
Metabolism. 2007
PubMed ID: 17884454
-
Pre-spliceosomal binding of U1 small nuclear ribonucleoprotein (RNP) and heterogenous nuclear RNP E1 is associated with suppression of a growth hormone receptor pseudoexon.
Akker SA, Misra S, Aslam S, Morgan EL, Smith PJ, Khoo B, Chew SL
Mol Endocrinol. 2007
PubMed ID: 17622584
-
Exon 3-deleted genotype of growth hormone receptor (GHRd3) positively influences IGF-1 increase at generation test in children with idiopathic short stature.
Toyoshima MT, Castroneves LA, Costalonga EF, Mendonca BB, Arnhold IJ, Jorge AA
Clin Endocrinol (Oxf). 2007
PubMed ID: 17555512
-
GHR exon 3 polymorphism: association with type 2 diabetes mellitus and metabolic disorder.
Strawbridge RJ, Kärvestedt L, Li C, Efendic S, Ostenson CG, Gu HF, Brismar K
Growth Horm IGF Res. 2007
PubMed ID: 17537658
-
GH responsiveness in a large multinational cohort of SGA children with short stature (NESTEGG) is related to the exon 3 GHR polymorphism.
Tauber M, Ester W, Auriol F, Molinas C, Fauvel J, Caliebe J, Nugent T, Fryklund L, Ranke MB, Savage MO, Clark AJ, Johnston LB, Hokken-Koelega AC, NESTEGG group
Clin Endocrinol (Oxf). 2007
PubMed ID: 17555507
-
Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation.
Lettre G, Butler JL, Ardlie KG, Hirschhorn JN
Hum Genet. 2007
PubMed ID: 17546465
-
Genetic association study of growth hormone receptor and idiopathic scoliosis.
Qiu XS, Tang NL, Yeung HY, Qiu Y, Cheng JC
Clin Orthop Relat Res. 2007
PubMed ID: 17514010
-
[Is polymorphism of CALM1 gene or growth hormone receptor gene associated with susceptibility to adolescent idiopathic scoliosis?]
Zhuang QY, Wu ZH, Qiu GX
Zhonghua Yi Xue Za Zhi. 2007
PubMed ID: 18001530
-
Insulin regulation of growth hormone receptor gene expression. Evidence for a transcriptional mechanism of down-regulation in rat hepatoma cells.
Bennett WL, Ji S, Messina JL
Mol Cell Endocrinol. 2007
PubMed ID: 17658679
-
Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways.
Dejkhamron P, Thimmarayappa J, Kotlyarevska K, Sun J, Lu C, Bonkowski EL, Denson LA, Menon RK
Mol Cell Endocrinol. 2007
PubMed ID: 17601656
-
Clinical features and growth hormone receptor gene mutations of patients with Laron syndrome from a Chinese family.
Ying YQ, Wei H, Cao LZ, Lu JJ, Luo XP
Zhongguo Dang Dai Er Ke Za Zhi. 2007
PubMed ID: 17706034
-
A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors.
Asa SL, Digiovanni R, Jiang J, Ward ML, Loesch K, Yamada S, Sano T, Yoshimoto K, Frank SJ, Ezzat S
Cancer Res. 2007
PubMed ID: 17671221
-
Growth hormone (GH) receptor isoform in acromegaly: lower concentrations of GH but not insulin-like growth factor-1 in patients with a genomic deletion of exon 3 in the GH receptor gene.
Schmid C, Krayenbuehl PA, Bernays RL, Zwimpfer C, Maly FE, Wiesli P
Clin Chem. 2007
PubMed ID: 17573420
-
The Leu544Ile polymorphism of the growth hormone receptor gene affects the serum cholesterol levels during GH treatment in children with GH deficiency.
Ihara K, Inuo M, Kuromaru R, Miyako K, Kohno H, Kinukawa N, Hara T
Clin Endocrinol (Oxf). 2007
PubMed ID: 17547682
-
CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice.
Kelder B, Berryman DE, Clark R, Li A, List EO, Kopchick JJ
Growth Horm IGF Res. 2007
PubMed ID: 17544797
-
Short stature and decreased insulin-like growth factor I (IGF-I)/growth hormone (GH)-ratio in an adult GH-deficient patient pointing to additional partial GH insensitivity due to a R179C mutation of the growth hormone receptor.
Meyer S, Ipek M, Keth A, Minnemann T, von Mach MA, Weise A, Ittner JR, Nawroth PP, Plöckinger U, Stalla GK, Tuschy U, Weber MM, Kann PH, German KIMS Board, German KIMS Pharmacogenetics Study Group
Growth Horm IGF Res. 2007
PubMed ID: 17462934
-
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor.
van Kerkhof P, Putters J, Strous GJ
J Biol Chem. 2007
PubMed ID: 17500058
-
Identification of a novel mutation in the human growth hormone receptor gene (GHR) in a patient with Laron syndrome.
Gennero I, Edouard T, Rashad M, Bieth E, Conte-Aurio F, Marin F, Tauber M, Salles JP, El Kholy M
J Pediatr Endocrinol Metab. 2007
PubMed ID: 17849745
-
The presence of the d3-growth hormone receptor polymorphism is negatively associated with fetal growth but positively associated with postnatal growth in healthy subjects.
Jensen RB, Vielwerth S, Larsen T, Greisen G, Leffers H, Juul A
J Clin Endocrinol Metab. 2007
PubMed ID: 17426087
-
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Wu C, Ma MH, Brown KR, Geisler M, Li L, Tzeng E, Jia CY, Jurisica I, Li SS
Proteomics. 2007
PubMed ID: 17474147
-
Primary growth hormone (GH) insensitivity and insulin-like growth factor deficiency caused by novel compound heterozygous mutations of the GH receptor gene: genetic and functional studies of simple and compound heterozygous states.
Fang P, Riedl S, Amselem S, Pratt KL, Little BM, Haeusler G, Hwa V, Frisch H, Rosenfeld RG
J Clin Endocrinol Metab. 2007
PubMed ID: 17405847
-
Effects of heterozygosity for the E180 splice mutation causing growth hormone receptor deficiency in Ecuador on IGF-I, IGFBP-3, and stature.
Guevara-Aguirre J, Rosenbloom AL, Guevara-Aguirre M, Yariz K, Saavedra J, Baumbach L, Shuster J
Growth Horm IGF Res. 2007
PubMed ID: 17350302
-
Growth hormone receptor gene mutations in two Italian patients with Laron Syndrome.
Fassone L, Corneli G, Bellone S, Camacho-Hübner C, Aimaretti G, Cappa M, Ubertini G, Bona G
J Endocrinol Invest. 2007
PubMed ID: 17598975
-
Mouse molar dentin size/shape is dependent on growth hormone status.
Smid JR, Rowland JE, Young WG, Coschigano KT, Kopchick JJ, Waters MJ
J Dent Res. 2007
PubMed ID: 17452569
-
Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency.
Davies JS, Gevers EF, Stevenson AE, Coschigano KT, El-Kasti MM, Bull MJ, Elford C, Evans BA, Kopchick JJ, Wells T
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17264226
-
Growth hormone receptor deficiency in mice results in reduced systolic blood pressure and plasma renin, increased aortic eNOS expression, and altered cardiovascular structure and function.
Egecioglu E, Andersson IJ, Bollano E, Palsdottir V, Gabrielsson BG, Kopchick JJ, Skott O, Bie P, Isgaard J, Bohlooly-Y M, Bergström G, Wickman A
Am J Physiol Endocrinol Metab. 2007
PubMed ID: 17244725
-
Distinct neuronal growth hormone receptor ligand specificity in the rat brain.
Möderscheim TA, Christophidis LJ, Williams CE, Scheepens A
Brain Res. 2007
PubMed ID: 17258692
-
Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A
Clin Cancer Res. 2007
PubMed ID: 17289896
-
Growth hormone-binding protein is directly and IGFBP-3 is inversely associated with risk of female breast cancer.
Pazaitou-Panayiotou K, Kelesidis T, Kelesidis I, Kaprara A, Blakeman J, Vainas I, Mpousoulegas A, Williams CJ, Mantzoros C
Eur J Endocrinol. 2007
PubMed ID: 17287408
-
An intronic growth hormone receptor mutation causing activation of a pseudoexon is associated with a broad spectrum of growth hormone insensitivity phenotypes.
David A, Camacho-Hübner C, Bhangoo A, Rose SJ, Miraki-Moud F, Akker SA, Butler GE, Ten S, Clayton PE, Clark AJ, Savage MO, Metherell LA
J Clin Endocrinol Metab. 2007
PubMed ID: 17148568
-
Relationship of the human growth hormone receptor exon 3 genotype with final adult height and bone mineral density.
Kenth G, Shao Z, Cole DE, Goodyer CG
J Clin Endocrinol Metab. 2007
PubMed ID: 17090634
-
Acetaminophen recruits spinal p42/p44 MAPKs and GH/IGF-1 receptors to produce analgesia via the serotonergic system.
Bonnefont J, Daulhac L, Etienne M, Chapuy E, Mallet C, Ouchchane L, Deval C, Courade JP, Ferrara M, Eschalier A, Clottes E
Mol Pharmacol. 2007
PubMed ID: 17088403
-
Growth hormone receptor polymorphisms.
Buzi F, Mella P, Pilotta A, Prandi E, Lanfranchi F, Carapella T
Endocr Dev. 2007
PubMed ID: 17986824
-
Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis.
O'Leary MJ, Xue A, Scarlett CJ, Sevette A, Kee AJ, Smith RC
Crit Care. 2007
PubMed ID: 17634149
-
Relationship between nocturnal growth hormone concentrations, serum IGF-I/IGFBP-3 levels, insulin sensitivity and GH receptor allelic variant in small for gestational age children.
Mericq V, Román R, Iñiguez G, Angel B, Salazar T, Avila A, Perez-Bravo F, Cassorla F
Horm Res. 2007
PubMed ID: 17347571
-
Haplotype-based analysis of common variation in the growth hormone receptor gene and prostate cancer risk.
McKay JD, Kaaks R, Johansson M, Biessy C, Wiklund F, Bälter K, Adami HO, Boillot C, Gioia-Patricola L, Canzian F, Stattin P, Grönberg H
Cancer Epidemiol Biomarkers Prev. 2007
PubMed ID: 17220348
-
Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling.
Zhang X, Mehta RG, Lantvit DD, Coschigano KT, Kopchick JJ, Green JE, Hedayat S, Christov KT, Ray VH, Unterman TG, Swanson SM
Carcinogenesis. 2007
PubMed ID: 16916863
-
Exon 3-deleted/full-length growth hormone receptor polymorphism genotype frequencies in Spanish short small-for-gestational-age (SGA) children and adolescents (n = 247) and in an adult control population (n = 289) show increased fl/fl in short SGA.
Audí L, Esteban C, Carrascosa A, Espadero R, Pérez-Arroyo A, Arjona R, Clemente M, Wollmann H, Fryklund L, Parodi LA, Spanish SGA Study Group
J Clin Endocrinol Metab. 2006
PubMed ID: 17003087
-
Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus.
Adriani M, Garbi C, Amodio G, Russo I, Giovannini M, Amorosi S, Matrecano E, Cosentini E, Candotti F, Pignata C
J Immunol. 2006
PubMed ID: 17082603
-
[Mutation of growth hormone receptor gene in patients with short stature]
Song F, Dai YH, Bao XL, Chen XL, Jin YW
Zhonghua Er Ke Za Zhi. 2006
PubMed ID: 17274879
-
GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus.
Jørgensen JO, Jessen N, Pedersen SB, Vestergaard E, Gormsen L, Lund SA, Billestrup N
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16757551
-
Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon proliferation, differentiation and hormone sensitivity.
Flint DJ, Binart N, Boumard S, Kopchick JJ, Kelly P
J Endocrinol. 2006
PubMed ID: 17065393
-
Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.
Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, Kamide K, Kawano Y, Miyata T
Hypertens Res. 2006
PubMed ID: 17137217
-
Pituitary mRNA expression of the growth hormone axis in the 1-year-old intrauterine growth restricted rat.
Prins T, Fodor M, Delemarre-van de Waal HA
J Neuroendocrinol. 2006
PubMed ID: 16867182
-
Variants in the GH-IGF axis confer susceptibility to lung cancer.
Rudd MF, Webb EL, Matakidou A, Sellick GS, Williams RD, Bridle H, Eisen T, Houlston RS, GELCAPS Consortium
Genome Res. 2006
PubMed ID: 16741161
-
Subcellular shift of the hepatic growth hormone receptor with progression of hepatitis C virus-related chronic liver disease.
Vespasiani Gentilucci U, Perrone G, Galati G, D'Avola D, Zardi EM, Rabitti C, Bianchi A, De Dominicis E, Afeltra A, Picardi A
Histopathology. 2006
PubMed ID: 16722931
-
Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke.
Horan M, Newsway V, Yasmin, Lewis MD, Easter TE, Rees DA, Mahto A, Millar DS, Procter AM, Scanlon MF, Wilkinson IB, Hall IP, Wheatley A, Blakey J, Bath PM, Cockcroft JR, Krawczak M, Cooper DN
Hum Genet. 2006
PubMed ID: 16572267
-
Polymorphisms in the growth hormone receptor: a case-control study in breast cancer.
Wagner K, Hemminki K, Grzybowska E, Bermejo JL, Butkiewicz D, Pamula J, Pekala W, Försti A
Int J Cancer. 2006
PubMed ID: 16381017
-
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction.
Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16682650
-
Growth hormone promotes skeletal muscle cell fusion independent of insulin-like growth factor 1 up-regulation.
Sotiropoulos A, Ohanna M, Kedzia C, Menon RK, Kopchick JJ, Kelly PA, Pende M
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16670201
-
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
-
Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart.
Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Wang Z, Bartke A
Exp Gerontol. 2006
PubMed ID: 16524678
-
Reduced recruitment and survival of primordial and growing follicles in GH receptor-deficient mice.
Slot KA, Kastelijn J, Bachelot A, Kelly PA, Binart N, Teerds KJ
Reproduction. 2006
PubMed ID: 16514195
-
Common polymorphisms of the growth hormone (GH) receptor do not correlate with the growth response to exogenous recombinant human GH in GH-deficient children.
Pilotta A, Mella P, Filisetti M, Felappi B, Prandi E, Parrinello G, Notarangelo LD, Buzi F
J Clin Endocrinol Metab. 2006
PubMed ID: 16394090
-
Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA
J Clin Endocrinol Metab. 2006
PubMed ID: 16352683
-
Growth hormone (GH) pharmacogenetics: influence of GH receptor exon 3 retention or deletion on first-year growth response and final height in patients with severe GH deficiency.
Jorge AA, Marchisotti FG, Montenegro LR, Carvalho LR, Mendonca BB, Arnhold IJ
J Clin Endocrinol Metab. 2006
PubMed ID: 16291702
-
Growth hormone activity in mitochondria depends on GH receptor Box 1 and involves caveolar pathway targeting.
Perret-Vivancos C, Abbate A, Ardail D, Raccurt M, Usson Y, Lobie PE, Morel G
Exp Cell Res. 2006
PubMed ID: 16352305
-
The d3-growth hormone (GH) receptor polymorphism is associated with increased responsiveness to GH in Turner syndrome and short small-for-gestational-age children.
Binder G, Baur F, Schweizer R, Ranke MB
J Clin Endocrinol Metab. 2006
PubMed ID: 16291706
-
Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice.
Egecioglu E, Bjursell M, Ljungberg A, Dickson SL, Kopchick JJ, Bergström G, Svensson L, Oscarsson J, Törnell J, Bohlooly-Y M
Am J Physiol Endocrinol Metab. 2006
PubMed ID: 16174655
-
Regulation of 5'-promoter activity of the rat growth hormone and growth hormone-releasing hormone receptor genes in the MtT/S and MtT/E cells.
Nogami H, Hiraoka Y, Inoue K, Aiso S, Hisano S
Neuroendocrinology. 2006
PubMed ID: 17090972
-
Growth hormone receptor sequence changes do not play a role in determining height in children with idiopathic short stature.
Hujeirat Y, Hess O, Shalev S, Tenenbaum-Rakover Y
Horm Res. 2006
PubMed ID: 16582564
-
Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells.
Cool SM, Grünert M, Jackson R, Li H, Nurcombe V, Waters MJ
Biochem Biophys Res Commun. 2005
PubMed ID: 16259960
-
The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities.
Shevah O, Kornreich L, Galatzer A, Laron Z
Horm Metab Res. 2005
PubMed ID: 16372230
-
Heterozygous mutations of growth hormone receptor gene in children with idiopathic short stature.
Bonioli E, Tarò M, Rosa CL, Citana A, Bertorelli R, Morcaldi G, Gastaldi R, Coviello DA
Growth Horm IGF Res. 2005
PubMed ID: 16213173
-
Heterozygote effects in mice with partial truncations in the growth hormone receptor cytoplasmic domain: assessment of growth parameters and phenotype.
Rowland JE, Kerr LM, White M, Noakes PG, Waters MJ
Endocrinology. 2005
PubMed ID: 16166215
-
Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse.
Wang Z, Prins GS, Coschigano KT, Kopchick JJ, Green JE, Ray VH, Hedayat S, Christov KT, Unterman TG, Swanson SM
Endocrinology. 2005
PubMed ID: 16141391
-
Role of the cytokine-induced SH2 domain-containing protein CIS in growth hormone receptor internalization.
Landsman T, Waxman DJ
J Biol Chem. 2005
PubMed ID: 16154995
-
The growth hormone receptor gene is associated with mandibular height in a Chinese population.
Zhou J, Lu Y, Gao XH, Chen YC, Lu JJ, Bai YX, Shen Y, Wang BK
J Dent Res. 2005
PubMed ID: 16246940
-
Influence of growth hormone on the craniofacial complex of transgenic mice.
Ramirez-Yañez GO, Smid JR, Young WG, Waters MJ
Eur J Orthod. 2005
PubMed ID: 16107429
-
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
-
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
-
Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence.
Wolf N, Penn P, Pendergrass W, Van Remmen H, Bartke A, Rabinovitch P, Martin GM
Exp Eye Res. 2005
PubMed ID: 16129095
-
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Brown RJ, Adams JJ, Pelekanos RA, Wan Y, McKinstry WJ, Palethorpe K, Seeber RM, Monks TA, Eidne KA, Parker MW, Waters MJ
Nat Struct Mol Biol. 2005
PubMed ID: 16116438
-
Effects of caloric restriction on insulin pathway gene expression in the skeletal muscle and liver of normal and long-lived GHR-KO mice.
Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Bartke A
Exp Gerontol. 2005
PubMed ID: 16054319
-
Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Kouadio JL, Horn JR, Pal G, Kossiakoff AA
J Biol Chem. 2005
PubMed ID: 15857837
-
Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.
Salmon AB, Murakami S, Bartke A, Kopchick J, Yasumura K, Miller RA
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15701676
-
Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue.
Nilsson L, Binart N, Bohlooly-Y M, Bramnert M, Egecioglu E, Kindblom J, Kelly PA, Kopchick JJ, Ormandy CJ, Ling C, Billig H
Biochem Biophys Res Commun. 2005
PubMed ID: 15882993
-
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage.
Cowan JW, Wang X, Guan R, He K, Jiang J, Baumann G, Black RA, Wolfe MS, Frank SJ
J Biol Chem. 2005
PubMed ID: 15743767
-
Plasma ghrelin concentrations are lower in binge-eating disorder.
Geliebter A, Gluck ME, Hashim SA
J Nutr. 2005
PubMed ID: 15867334
-
Chromosomal mapping of a quantitative trait locus for the development of albuminuria in diabetic KK/Ta mice.
Shike T, Gohda T, Tanimoto M, Kobayashi M, Makita Y, Funabiki K, Horikoshi S, Hirose S, Shirai T, Tomino Y
Nephrol Dial Transplant. 2005
PubMed ID: 15769825
-
Growth hormone receptor mRNA expression in non-functioning and somatotroph pituitary adenomas: implications for growth hormone substitution therapy?
Beuschlein F, Hancke K, Petrick M, Göbel H, Honegger J, Reincke M
Exp Clin Endocrinol Diabetes. 2005
PubMed ID: 15891957
-
Isolation, characterization, and distribution of two cDNAs encoding for growth hormone receptor in rainbow trout (Oncorhynchus mykiss).
Very NM, Kittilson JD, Norbeck LA, Sheridan MA
Comp Biochem Physiol B Biochem Mol Biol. 2005
PubMed ID: 15763517
-
Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Pál G, Ultsch MH, Clark KP, Currell B, Kossiakoff AA, Sidhu SS
J Mol Biol. 2005
PubMed ID: 15755445
-
Spatial distribution of growth hormone receptor, insulin-like growth factor-I receptor and apoptotic chondrocytes during growth plate development.
Cruickshank J, Grossman DI, Peng RK, Famula TR, Oberbauer AM
J Endocrinol. 2005
PubMed ID: 15749813
-
Novel growth hormone receptor mutation in a Chinese patient with Laron syndrome.
Hui HN, Metherell LA, Ng KL, Savage MO, Camacho-Hübner C, Clark AJ
J Pediatr Endocrinol Metab. 2005
PubMed ID: 15751611
-
SOCS2 negatively regulates growth hormone action in vitro and in vivo.
Greenhalgh CJ, Rico-Bautista E, Lorentzon M, Thaus AL, Morgan PO, Willson TA, Zervoudakis P, Metcalf D, Street I, Nicola NA, Nash AD, Fabri LJ, Norstedt G, Ohlsson C, Flores-Morales A, Alexander WS, Hilton DJ
J Clin Invest. 2005
PubMed ID: 15690087
-
Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction.
Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A
Endocrinology. 2005
PubMed ID: 15498882
-
Distribution of growth hormone receptor mRNA in the brain stem and spinal cord of the rat.
Kastrup Y, Le Grevès M, Nyberg F, Blomqvist A
Neuroscience. 2005
PubMed ID: 15664698
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In vivo analysis of growth hormone receptor signaling domains and their associated transcripts.
Rowland JE, Lichanska AM, Kerr LM, White M, d'Aniello EM, Maher SL, Brown R, Teasdale RD, Noakes PG, Waters MJ
Mol Cell Biol. 2005
PubMed ID: 15601831
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The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Walsh ST, Sylvester JE, Kossiakoff AA
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15563602
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Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor.
McKinstry WJ, Wan Y, Adams JJ, Brown RJ, Waters MJ, Parker MW
Acta Crystallogr D Biol Crystallogr. 2004
PubMed ID: 15583394
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Lack of contribution of 11betaHSD1 and glucocorticoid action to reduced muscle mass associated with reduced growth hormone action.
Itoh E, Iida K, Kim DS, Del Rincon JP, Coschigano KT, Kopchick JJ, Thorner MO
Growth Horm IGF Res. 2004
PubMed ID: 15519255
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Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice.
Iida K, Itoh E, Kim DS, del Rincon JP, Coschigano KT, Kopchick JJ, Thorner MO
J Physiol. 2004
PubMed ID: 15308683
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Protective effects of recombinant human growth hormone on cirrhotic rats.
Chen S, Wang HT, Yang B, Fu YR, Ou QJ
World J Gastroenterol. 2004
PubMed ID: 15334695
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The DNA sequence and comparative analysis of human chromosome 5.
Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM
Nature. 2004
PubMed ID: 15372022
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Growth hormone and epidermal growth factor in salivary glands of giant and dwarf transgenic mice.
Young WG, Ramirez-Yañez GO, Daley TJ, Smid JR, Coshigano KT, Kopchick JJ, Waters MJ
J Histochem Cytochem. 2004
PubMed ID: 15314086
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Regulation of full-length and truncated growth hormone (GH) receptor by GH in tissues of lit/lit or bovine GH transgenic mice.
Iida K, del Rincon JP, Kim DS, Itoh E, Coschigano KT, Kopchick JJ, Thorner MO
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15165994
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Effects of Soy-derived diets on plasma and liver lipids, glucose tolerance, and longevity in normal, long-lived and short-lived mice.
Bartke A, Peluso MR, Moretz N, Wright C, Bonkowski M, Winters TA, Shanahan MF, Kopchick JJ, Banz WJ
Horm Metab Res. 2004
PubMed ID: 15326565
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Chronic changes in peripheral growth hormone levels do not affect ghrelin stomach mRNA expression and serum ghrelin levels in three transgenic mouse models.
Nass R, Liu J, Hellmann P, Coschigano KT, Gaylinn B, Berryman DE, Kopchick JJ, Thorner MO
J Neuroendocrinol. 2004
PubMed ID: 15271059
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Comparing adiposity profiles in three mouse models with altered GH signaling.
Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ
Growth Horm IGF Res. 2004
PubMed ID: 15231300
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Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells.
Weiss-Messer E, Merom O, Adi A, Karry R, Bidosee M, Ber R, Kaploun A, Stein A, Barkey RJ
Mol Cell Endocrinol. 2004
PubMed ID: 15196705
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Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling.
Yang N, Huang Y, Jiang J, Frank SJ
J Biol Chem. 2004
PubMed ID: 15010456
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Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness.
Ransome MI, Goldshmit Y, Bartlett PF, Waters MJ, Turnley AM
Eur J Neurosci. 2004
PubMed ID: 15090034
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Effect of two human growth hormone receptor antagonists on glomerulosclerosis in streptozotocin-induced diabetic rats.
Li W, Zhu LH, Wang EB, Ye ZC, Lin J, Guo LH, Luo FH, Liu XH, Fang X, Shen SX
Acta Pharmacol Sin. 2004
PubMed ID: 15066219
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High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A
Mol Cell Proteomics. 2004
PubMed ID: 14718574
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Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
Sun Y, Wang P, Zheng H, Smith RG
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15070777
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[Single nucleotide polymorphisms of growth hormone receptor gene in Chinese Han ethnic population]
Zhou J, Lu Y, Bai YX, Wang YP, Shen Y, Wang BK
Zhonghua Kou Qiang Yi Xue Za Zhi. 2004
PubMed ID: 15061875
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Growth hormone (GH) insensitivity syndrome due to a GH receptor truncated after Box1, resulting in isolated failure of STAT 5 signal transduction.
Milward A, Metherell L, Maamra M, Barahona MJ, Wilkinson IR, Camacho-Hübner C, Savage MO, Bidlingmaier CM, Clark AJ, Ross RJ, Webb SM
J Clin Endocrinol Metab. 2004
PubMed ID: 15001620
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Could a deficiency in growth hormone signaling be beneficial to the aging brain?
Kinney-Forshee BA, Kinney NE, Steger RW, Bartke A
Physiol Behav. 2004
PubMed ID: 14984790
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Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth.
Wang J, Zhou J, Cheng CM, Kopchick JJ, Bondy CA
J Endocrinol. 2004
PubMed ID: 14765976
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Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice.
Nukaya M, Takahashi Y, Gonzalez FJ, Kamataki T
FEBS Lett. 2004
PubMed ID: 14759523
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[Fine structure, expression and polymorphism of the human growth hormone receptor gene].
Orlovskiĭ IV, Sverdlova PS, Rubtsov PM
Mol Biol (Mosk). 2004
PubMed ID: 15042833
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Mouse cellular cementum is highly dependent on growth hormone status.
Smid JR, Rowland JE, Young WG, Daley TJ, Coschigano KT, Kopchick JJ, Waters MJ
J Dent Res. 2004
PubMed ID: 14691110
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The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: supression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration.
Jorge AA, Souza SC, Arnhold IJ, Mendonca BB
Clin Endocrinol (Oxf). 2004
PubMed ID: 14678285
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Growth hormone (GH)-stimulated insulin-like growth factor I gene expression is mediated by a tyrosine phosphorylation pathway depending on C-terminal region of human GH receptor in human GH receptor-expressing Ba/F3 cells.
Yoshizato H, Tanaka M, Nakai N, Nakao N, Nakashima K
Endocrinology. 2004
PubMed ID: 14551225
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Reduced growth hormone receptor immunoreactivity in osteoclasts adjacent to the erupting molar in the incisor-absent (osteopetrotic) rat.
Symons AL
Eur J Oral Sci. 2003
PubMed ID: 14632687
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Diverse regulation of full-length and truncated growth hormone receptor expression in 3T3-L1 adipocytes.
Iida K, Takahashi Y, Kaji H, Yoshioka S, Murata M, Iguchi G, Okimura Y, Chihara K
Mol Cell Endocrinol. 2003
PubMed ID: 14615057
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Human oocytes and preimplantation embryos express mRNA for growth hormone receptor.
Ménézo YJ, el Mouatassim S, Chavrier M, Servy EJ, Nicolet B
Zygote. 2003
PubMed ID: 15085728
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Genetic mouse models of extended lifespan.
Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A
Exp Gerontol. 2003
PubMed ID: 14698816
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The retardation of aging by caloric restriction: its significance in the transgenic era.
Barger JL, Walford RL, Weindruch R
Exp Gerontol. 2003
PubMed ID: 14698815
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Computational detection of the binding-site hot spot at the remodeled human growth hormone-receptor interface.
Verkhivker GM, Bouzida D, Gehlhaar DK, Rejto PA, Freer ST, Rose PW
Proteins. 2003
PubMed ID: 14517972
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Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor.
Pasquali C, Curchod ML, Wälchli S, Espanel X, Guerrier M, Arigoni F, Strous G, Van Huijsduijnen RH
Mol Endocrinol. 2003
PubMed ID: 12907755
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Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.
Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ
Endocrinology. 2003
PubMed ID: 12933651
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Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred.
Takada D, Ezura Y, Ono S, Iino Y, Katayama Y, Xin Y, Wu LL, Larringa-Shum S, Stephenson SH, Hunt SC, Hopkins PN, Emi M
Am J Med Genet A. 2003
PubMed ID: 12910492
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Genetic architecture of the mouse hippocampus: identification of gene loci with selective regional effects.
Peirce JL, Chesler EJ, Williams RW, Lu L
Genes Brain Behav. 2003
PubMed ID: 12953790
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Growth hormone receptor expression in atrophying muscle fibers of rats.
Casse AH, Desplanches D, Mayet-Sornay MH, Raccurt M, Jegou S, Morel G
Endocrinology. 2003
PubMed ID: 12865352
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Regulation of growth-hormone-receptor gene expression by growth hormone and pegvisomant in human mesangial cells.
Meinhardt U, Eblé A, Besson A, Strasburger CJ, Sraer JD, Mullis PE
Kidney Int. 2003
PubMed ID: 12846737
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Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor.
Schantl JA, Roza M, De Jong AP, Strous GJ
Biochem J. 2003
PubMed ID: 12735788
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Expression of p53, bcl-2 and growth hormone receptor in actinic keratosis, hypertrophic type.
Stanimirović A, Cupić H, Bosnjak B, Kruslin B, Belicza M
Arch Dermatol Res. 2003
PubMed ID: 12756585
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Expression of growth hormone receptor and its mRNA in hepatic cirrhosis.
Wang HT, Chen S, Wang J, Ou QJ, Liu C, Zheng SS, Deng MH, Liu XP
World J Gastroenterol. 2003
PubMed ID: 12679928
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Heterozygous nonsense mutation in exon 3 of the growth hormone receptor (GHR) in severe GH insensitivity (Laron syndrome) and the issue of the origin and function of the GHRd3 isoform.
Pantel J, Grulich-Henn J, Bettendorf M, Strasburger CJ, Heinrich U, Amselem S
J Clin Endocrinol Metab. 2003
PubMed ID: 12679461
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Association between the GH receptor/exon 3 genotype and the level of exon 3-positive GH-binding protein in human serum.
Seidel B, Glasow A, Schutt M, Kiess W, Wu Z, Strasburger CJ, Kratzsch J
Eur J Endocrinol. 2003
PubMed ID: 12611612
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Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes.
Du L, Frick GP, Tai LR, Yoshimura A, Goodman HM
Endocrinology. 2003
PubMed ID: 12586763
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The growth hormone-binding protein is a location-dependent cytokine receptor transcriptional enhancer.
Graichen R, Sandstedt J, Goh EL, Isaksson OG, Törnell J, Lobie PE
J Biol Chem. 2003
PubMed ID: 12488452
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Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Leung KC, Doyle N, Ballesteros M, Sjogren K, Watts CK, Low TH, Leong GM, Ross RJ, Ho KK
Proc Natl Acad Sci U S A. 2003
PubMed ID: 12552091
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Genetic disruption of the growth hormone receptor does not influence motoneuron survival in the developing mouse.
Parsons SA, Banks GB, Rowland JA, Coschigano KT, Kopchick JJ, Waters MJ, Noakes PG
Int J Dev Biol. 2003
PubMed ID: 12653250
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Enlargement of interscapular brown adipose tissue in growth hormone antagonist transgenic and in growth hormone receptor gene-disrupted dwarf mice.
Li Y, Knapp JR, Kopchick JJ
Exp Biol Med (Maywood). 2003
PubMed ID: 12563029
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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[Growth hormone insensitivity of rats under the endotoxemic condition]
Wang P, Li N, Li J, Li W
Zhonghua Wai Ke Za Zhi. 2002
PubMed ID: 12654216
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A novel heterozygous T51I mutation of growth hormone receptor is not associated with short stature.
Sakurai T, Iida K, Takahashi Y, Kaji H, Takakuwa S, Sumita R, Okimura Y, Chihara K
Growth Horm IGF Res. 2002
PubMed ID: 12423626
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Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice.
Miller RA, Chang Y, Galecki AT, Al-Regaiey K, Kopchick JJ, Bartke A
Mol Endocrinol. 2002
PubMed ID: 12403853
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Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling.
Turnley AM, Faux CH, Rietze RL, Coonan JR, Bartlett PF
Nat Neurosci. 2002
PubMed ID: 12368809
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Structure and regulation of expression of the mouse GH receptor.
Talamantes F, Ortiz R
J Endocrinol. 2002
PubMed ID: 12379490
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Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice.
Zaczek D, Hammond J, Suen L, Wandji S, Service D, Bartke A, Chandrashekar V, Coschigano K, Kopchick J
Biol Reprod. 2002
PubMed ID: 12297526
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Growth hormone is required for ovarian follicular growth.
Bachelot A, Monget P, Imbert-Bolloré P, Coshigano K, Kopchick JJ, Kelly PA, Binart N
Endocrinology. 2002
PubMed ID: 12239122
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Antioxidant enzymes, free-radical damage, and response to paraquat in liver and kidney of long-living growth hormone receptor/binding protein gene-disrupted mice.
Hauck SJ, Aaron JM, Wright C, Kopchick JJ, Bartke A
Horm Metab Res. 2002
PubMed ID: 12384824
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Puberty is delayed in male growth hormone receptor gene-disrupted mice.
Keene DE, Suescun MO, Bostwick MG, Chandrashekar V, Bartke A, Kopchick JJ
J Androl. 2002
PubMed ID: 12185100
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Hoxa5 overexpression correlates with IGFBP1 upregulation and postnatal dwarfism: evidence for an interaction between Hoxa5 and Forkhead box transcription factors.
Foucher I, Volovitch M, Frain M, Kim JJ, Souberbielle JC, Gan L, Unterman TG, Prochiantz A, Trembleau A
Development. 2002
PubMed ID: 12163409
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Localization and regulation of the growth hormone receptor and growth hormone-binding protein in the rat growth plate.
Gevers EF, van der Eerden BC, Karperien M, Raap AK, Robinson IC, Wit JM
J Bone Miner Res. 2002
PubMed ID: 12162495
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G120K-PEG, a human GH antagonist, decreases GH signal transduction in the liver of mice.
Thirone AC, Carvalho CR, Saad MJ
Mol Cell Endocrinol. 2002
PubMed ID: 12088868
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A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
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Growth hormone binding protein, insulin-like growth factor-I and short stature in two pygmy populations from the Philippines.
Dávila N, Shea BT, Omoto K, Mercado M, Misawa S, Baumann G
J Pediatr Endocrinol Metab. 2002
PubMed ID: 11924928
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Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Schiffer C, Ultsch M, Walsh S, Somers W, de Vos AM, Kossiakoff A
J Mol Biol. 2002
PubMed ID: 11851338
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Immunohistochemical localisation of growth hormone (GH), GH receptor (GHR), insulin-like growth factor I (IGF-I) and type I IGF-I receptor, and gene expression of GH and GHR in rat pre-antral follicles.
Zhao J, Taverne MA, van der Weijden GC, Bevers MM, van den Hurk R
Zygote. 2002
PubMed ID: 11964096
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Structurally distinct membrane-associated and soluble forms of GH-binding protein in the mouse.
Cerio RJ, Xing F, Fatula RJ, Keith DE, Yang X, Talamantes F, Southard JN, Southard JN
J Endocrinol. 2002
PubMed ID: 11834450
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Identification of a region critical for proteolysis of the human growth hormone receptor.
Conte F, Salles JP, Raynal P, Fernandez L, Molinas C, Tauber M, Bieth E
Biochem Biophys Res Commun. 2002
PubMed ID: 11785980
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Alu elements in human growth hormone receptor gene 5' untranslated region exons.
Goodyer CG, Zheng H, Hendy GN
J Mol Endocrinol. 2001
PubMed ID: 11719288
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Mutations in the human orthologue of the mouse underwhite gene (uw) underlie a new form of oculocutaneous albinism, OCA4.
Newton JM, Cohen-Barak O, Hagiwara N, Gardner JM, Davisson MT, King RA, Brilliant MH
Am J Hum Genet. 2001
PubMed ID: 11574907
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The effect of GHRH on somatotrope hyperplasia and tumor formation in the presence and absence of GH signaling.
Kineman RD, Teixeira LT, Amargo GV, Coschigano KT, Kopchick JJ, Frohman LA
Endocrinology. 2001
PubMed ID: 11517152
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GT repeat polymorphism in the 5' flanking region of the human growth hormone receptor gene.
Hadjiyannakis S, Zheng H, Hendy GN, Goodyer CG
Mol Cell Probes. 2001
PubMed ID: 11513560
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Susceptibility and negative epistatic loci contributing to type 2 diabetes and related phenotypes in a KK/Ta mouse model.
Shike T, Hirose S, Kobayashi M, Funabiki K, Shirai T, Tomino Y
Diabetes. 2001
PubMed ID: 11473059
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Testicular endocrine function in GH receptor gene disrupted mice.
Chandrashekar V, Bartke A, Awoniyi CA, Tsai-Morris CH, Dufau ML, Russell LD, Kopchick JJ
Endocrinology. 2001
PubMed ID: 11459789
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Proteasomes are involved in the constitutive degradation of growth hormone receptors.
Takagi K, Saito Y, Sawada JI
Biol Pharm Bull. 2001
PubMed ID: 11456111
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Reduced levels of thyroid hormones, insulin, and glucose, and lower body core temperature in the growth hormone receptor/binding protein knockout mouse.
Hauck SJ, Hunter WS, Danilovich N, Kopchick JJ, Bartke A
Exp Biol Med (Maywood). 2001
PubMed ID: 11395925
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Involvement of hepatocyte nuclear factor-4 in the expression of the growth hormone receptor 1A messenger ribonucleic acid in bovine liver.
Jiang H, Lucy MC
Mol Endocrinol. 2001
PubMed ID: 11376119
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Morphine decreases the levels of the gene transcripts of growth hormone receptor and growth hormone binding protein in the male rat hippocampus and spinal cord.
Thörnwall-Le Grevès M, Zhou Q, Lagerholm S, Huang W, Le Grevès P, Nyberg F
Neurosci Lett. 2001
PubMed ID: 11335057
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Organization and evolution of the human growth hormone receptor gene 5'-flanking region.
Goodyer CG, Zogopoulos G, Schwartzbauer G, Zheng H, Hendy GN, Menon RK
Endocrinology. 2001
PubMed ID: 11316758
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Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice.
Kinney BA, Coschigano KT, Kopchick JJ, Steger RW, Bartke A
Physiol Behav. 2001
PubMed ID: 11336996
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The growth hormone (GH)-axis of GH receptor/binding protein gene-disrupted and metallothionein-human GH-releasing hormone transgenic mice: hypothalamic neuropeptide and pituitary receptor expression in the absence and presence of GH feedback.
Peng XD, Park S, Gadelha MR, Coschigano KT, Kopchick JJ, Frohman LA, Kineman RD
Endocrinology. 2001
PubMed ID: 11181526
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Growth hormone receptor interaction with Jak proteins differs between tissues.
Hellgren G, Albertsson-Wikland K, Billig H, Carlsson LM, Carlsson B
J Interferon Cytokine Res. 2001
PubMed ID: 11244571
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Gene expression of a truncated and the full-length growth hormone (GH) receptor in subcutaneous fat and skeletal muscle in GH-deficient adults: impact of GH treatment.
Fisker S, Kristensen K, Rosenfalck AM, Pedersen SB, Ebdrup L, Richelsen B, Hilsted J, Christiansen JS, Jørgensen JO
J Clin Endocrinol Metab. 2001
PubMed ID: 11158048
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Growth hormone exerts antiapoptotic and proliferative effects through two different pathways involving nuclear factor-kappaB and phosphatidylinositol 3-kinase.
Jeay S, Sonenshein GE, Kelly PA, Postel-Vinay MC, Baixeras E
Endocrinology. 2001
PubMed ID: 11145577
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Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.
Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L
Dev Biol. 2001
PubMed ID: 11133161
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Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
Lupu F, Terwilliger JD, Lee K, Segre GV, Efstratiadis A
Dev Biol. 2001
PubMed ID: 11133160
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5.
Sims NA, Clément-Lacroix P, Da Ponte F, Bouali Y, Binart N, Moriggl R, Goffin V, Coschigano K, Gaillard-Kelly M, Kopchick J, Baron R, Kelly PA
J Clin Invest. 2000
PubMed ID: 11067862
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Activation of the Jak/Stat signal transduction pathway in GH-treated rat osteoblast-like cells in culture.
Gerland K, Bataillé-Simoneau N, Baslé M, Fourcin M, Gascan H, Mercier L
Mol Cell Endocrinol. 2000
PubMed ID: 11064147
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In rats with sepsis, the acute fall in IGF-I is associated with an increase in circulating growth hormone-binding protein levels.
O'Leary MJ, Quinton N, Ferguson CN, Preedy VR, Ross RJ, Hinds CJ
Intensive Care Med. 2000
PubMed ID: 11126270
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Alternative 5'-untranslated regions of mouse GH receptor/binding protein messenger RNA are derived from sequences adjacent to the major L2 promoter.
Moffat JG, Dao H, Talamantes F
J Endocrinol. 2000
PubMed ID: 11018762
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Mutation of the SHP-2 binding site in growth hormone (GH) receptor prolongs GH-promoted tyrosyl phosphorylation of GH receptor, JAK2, and STAT5B.
Stofega MR, Herrington J, Billestrup N, Carter-Su C
Mol Endocrinol. 2000
PubMed ID: 10976913
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Compensatory alterations of insulin signal transduction in liver of growth hormone receptor knockout mice.
Dominici FP, Arostegui Diaz G, Bartke A, Kopchick JJ, Turyn D
J Endocrinol. 2000
PubMed ID: 10974652
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Assessment of growth parameters and life span of GHR/BP gene-disrupted mice.
Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ
Endocrinology. 2000
PubMed ID: 10875265
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Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation.
Enberg B, Luthman H, Segnestam K, Ritzén EM, Sundström M, Norstedt G
Eur J Endocrinol. 2000
PubMed ID: 10870033
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A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.
Mahajan MA, Samuels HH
Mol Cell Biol. 2000
PubMed ID: 10866662
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Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution.
Pantel J, Machinis K, Sobrier ML, Duquesnoy P, Goossens M, Amselem S
J Biol Chem. 2000
PubMed ID: 10764769
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The human growth hormone receptor gene - characterisation of the liver-specific promoter.
Rivers CA, Norman MR
Mol Cell Endocrinol. 2000
PubMed ID: 10715538
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Disproportional skeletal growth and markedly decreased bone mineral content in growth hormone receptor -/- mice.
Sjögren K, Bohlooly-Y M, Bohlooly YM, Olsson B, Coschigano K, Törnell J, Mohan S, Isaksson OG, Baumann G, Kopchick J, Ohlsson C
Biochem Biophys Res Commun. 2000
PubMed ID: 10631109
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Protection against diabetes-induced nephropathy in growth hormone receptor/binding protein gene-disrupted mice.
Bellush LL, Doublier S, Holland AN, Striker LJ, Striker GE, Kopchick JJ
Endocrinology. 2000
PubMed ID: 10614635
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SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.
Ram PA, Waxman DJ
J Biol Chem. 1999
PubMed ID: 10585430
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A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.
Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW
J Biol Chem. 1999
PubMed ID: 10567404
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Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice.
Bartke A, Chandrashekar V, Turyn D, Steger RW, Debeljuk L, Winters TA, Mattison JA, Danilovich NA, Croson W, Wernsing DR, Kopchick JJ
Proc Soc Exp Biol Med. 1999
PubMed ID: 10564535
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Up-regulation of GH-binding protein by mouse GH in transgenic mice overexpressing GH-releasing hormone.
González L, Sotelo AI, Bartke A, Turyn D
J Endocrinol. 1999
PubMed ID: 10556780
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Growth hormone resistance: clinical states and animal models.
Hull KL, Harvey S
J Endocrinol. 1999
PubMed ID: 10556764
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A beta-turn endocytic code is required for optimal internalization of the growth hormone receptor but not for alpha-adaptin association.
Vleurick L, Pezet A, Kühn ER, Decuypere E, Edery M
Mol Endocrinol. 1999
PubMed ID: 10551776
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Role of growth hormone and prolactin in the control of reproduction: what are we learning from transgenic and knock-out animals?
Bartke A
Steroids. 1999
PubMed ID: 10503715
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Analysis of a 762-bp proximal leptin promoter to drive and control regulation of transgene expression of growth hormone receptor in mice.
Chen XL, Hartzell DL, McGraw RA, Hausman GJ, Dean RG
Biochem Biophys Res Commun. 1999
PubMed ID: 10448090
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Structure and expression of the mouse growth hormone receptor/growth hormone binding protein gene.
Moffat JG, Edens A, Talamantes F
J Mol Endocrinol. 1999
PubMed ID: 10425445
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Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES
Nat Genet. 1999
PubMed ID: 10391209
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The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver.
Hellgren G, Jansson JO, Carlsson LM, Carlsson B
Growth Horm IGF Res. 1999
PubMed ID: 10502458
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Deficits in female reproductive function in GH-R-KO mice; role of IGF-I.
Danilovich N, Wernsing D, Coschigano KT, Kopchick JJ, Bartke A
Endocrinology. 1999
PubMed ID: 10342852
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Pituitary and testicular function in growth hormone receptor gene knockout mice.
Chandrashekar V, Bartke A, Coschigano KT, Kopchick JJ
Endocrinology. 1999
PubMed ID: 10067829
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The human growth hormone (GH) receptor and its truncated isoform: sulfhydryl group inactivation in the study of receptor internalization and GH-binding protein generation.
Amit T, Bar-Am O, Dastot F, Youdim MB, Amselem S, Hochberg Z
Endocrinology. 1999
PubMed ID: 9886834
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor.
Wojcik J, Berg MA, Esposito N, Geffner ME, Sakati N, Reiter EO, Dower S, Francke U, Postel-Vinay MC, Finidori J
J Clin Endocrinol Metab. 1998
PubMed ID: 9851797
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Growth hormone receptor mutations in children with idiopathic short stature.
Sanchez JE, Perera E, Baumbach L, Cleveland WW
J Clin Endocrinol Metab. 1998
PubMed ID: 9814495
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ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization.
Cases S, Novak S, Zheng YW, Myers HM, Lear SR, Sande E, Welch CB, Lusis AJ, Spencer TA, Krause BR, Erickson SK, Farese RV
J Biol Chem. 1998
PubMed ID: 9756919
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A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue.
Walker JL, Crock PA, Behncken SN, Rowlinson SW, Nicholson LM, Boulton TJ, Waters MJ
J Clin Endocrinol Metab. 1998
PubMed ID: 9661642
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Assignment of the growth hormone receptor gene to band q17 of the homeologous sheep 16 and cattle 20 chromosomes.
Parsons YM, Webb GC, Bottema CD
Mamm Genome. 1998
PubMed ID: 9657863
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Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins.
Moutoussamy S, Renaudie F, Lago F, Kelly PA, Finidori J
J Biol Chem. 1998
PubMed ID: 9632636
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Molecular properties and chromosomal location of cadherin-8.
Kido M, Obata S, Tanihara H, Rochelle JM, Seldin MF, Taketani S, Suzuki ST
Genomics. 1998
PubMed ID: 9521872
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Differential expression of renal growth hormone receptor and its binding protein in experimental diabetes mellitus.
Landau D, Domene H, Flyvbjerg A, Grønbaek H, Roberts CT, Argov S, LeRoith D
Growth Horm IGF Res. 1998
PubMed ID: 10990443
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[Pro-inflammatory cytokines IL-1 beta and TNF-alpha reduce growth hormone receptor mRNA concentration in cultivated rat hepatocytes after stimulation with growth hormone]
Böhm SA, Wolf M, Kreymann G, Hölscher AH
Langenbecks Arch Chir Suppl Kongressbd. 1998
PubMed ID: 14518239
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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse).
Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Cataldo L, Coschigamo K, Wagner TE, Baumann G, Kopchick JJ
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9371826
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Structural plasticity in a remodeled protein-protein interface.
Atwell S, Ultsch M, De Vos AM, Wells JA
Science. 1997
PubMed ID: 9353194
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A membrane-fixed, truncated isoform of the human growth hormone receptor.
Amit T, Bergman T, Dastot F, Youdim MB, Amselem S, Hochberg Z
J Clin Endocrinol Metab. 1997
PubMed ID: 9360546
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Aspartate 171 is the major primate-specific determinant of human growth hormone. Engineering porcine growth hormone to activate the human receptor.
Behncken SN, Rowlinson SW, Rowland JE, Conway-Campbell BL, Monks TA, Waters MJ
J Biol Chem. 1997
PubMed ID: 9341147
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Growth hormone-induced tyrosyl phosphorylation and deoxyribonucleic acid binding activity of Stat5A and Stat5B.
Smit LS, Vanderkuur JA, Stimage A, Han Y, Luo G, Yu-Lee LY, Schwartz J, Carter-Su C
Endocrinology. 1997
PubMed ID: 9231797
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Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively.
Klingenspor M, Bodnar J, Xia YR, Welch C, Lusis AJ, Reue K
Mamm Genome. 1997
PubMed ID: 9196007
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Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis?
Pantaleon M, Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9144201
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A dominant-negative mutation of the growth hormone receptor causes familial short stature.
Ayling RM, Ross R, Towner P, Von Laue S, Finidori J, Moutoussamy S, Buchanan CR, Clayton PE, Norman MR
Nat Genet. 1997
PubMed ID: 9140387
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Liver and kidney growth hormone (GH) receptors are regulated differently in diabetic GH and GH antagonist transgenic mice.
Chen NY, Chen WY, Kopchick JJ
Endocrinology. 1997
PubMed ID: 9112397
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Isolation of a liver-specific promoter for human growth hormone receptor gene.
Zou L, Burmeister LA, Sperling MA
Endocrinology. 1997
PubMed ID: 9075743
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A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.
Ross RJ, Esposito N, Shen XY, Von Laue S, Chew SL, Dobson PR, Postel-Vinay MC, Finidori J
Mol Endocrinol. 1997
PubMed ID: 9058373
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Nine novel growth hormone receptor gene mutations in patients with Laron syndrome.
Sobrier ML, Dastot F, Duquesnoy P, Kandemir N, Yordam N, Goossens M, Amselem S
J Clin Endocrinol Metab. 1997
PubMed ID: 9024232
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Induction of mRNAs for the growth hormone receptor gene during mouse 3T3-L1 preadipocyte differentiation.
Zou L, Menon RK, Sperling MA
Metabolism. 1997
PubMed ID: 9005979
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Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.
Sundström M, Lundqvist T, Rödin J, Giebel LB, Milligan D, Norstedt G
J Biol Chem. 1996
PubMed ID: 8943276
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Genetics of obesity: advances from rodent studies.
Chagnon YC, Bouchard C
Trends Genet. 1996
PubMed ID: 8973143
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Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase.
Yi W, Kim SO, Jiang J, Park SH, Kraft AS, Waxman DJ, Frank SJ
Mol Endocrinol. 1996
PubMed ID: 8923468
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Alternative splicing of exon 3 of the human growth hormone receptor is the result of an unusual genetic polymorphism.
Stallings-Mann ML, Ludwiczak RL, Klinger KW, Rottman F
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8901592
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Structural comparison of a portion of the rat and mouse growth hormone receptor/binding protein genes.
Zhou Y, He L, Kopchick JJ
Gene. 1996
PubMed ID: 8921876
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Identification of growth hormone receptor (GHR) tyrosine residues required for GHR phosphorylation and JAK2 and STAT5 activation.
Wang X, Darus CJ, Xu BC, Kopchick JJ
Mol Endocrinol. 1996
PubMed ID: 9121492
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Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.
Dastot F, Sobrier ML, Duquesnoy P, Duriez B, Goossens M, Amselem S
Proc Natl Acad Sci U S A. 1996
PubMed ID: 8855247
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Mapping of unconventional myosins in mouse and human.
Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA
Genomics. 1996
PubMed ID: 8884266
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Normalization and subtraction: two approaches to facilitate gene discovery.
Bonaldo MF, Lennon G, Soares MB
Genome Res. 1996
PubMed ID: 8889548
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Growth hormone promotes the association of transcription factor STAT5 with the growth hormone receptor.
Xu BC, Wang X, Darus CJ, Kopchick JJ
J Biol Chem. 1996
PubMed ID: 8702683
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Multiple mouse chromosomal loci for dynein-based motility.
Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB
Genomics. 1996
PubMed ID: 8812413
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Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes.
Welch CL, Xia YR, Shechter I, Farese R, Mehrabian M, Mehdizadeh S, Warden CH, Lusis AJ
J Lipid Res. 1996
PubMed ID: 8827514
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Localization of mouse peroxisome proliferator-activated receptor gamma on chromosome 6.
Reue K, Xia Y, Shi VW, Cohen RD, Welch C, Lusis AJ
Mamm Genome. 1996
PubMed ID: 8661743
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Expression of exon 3-retaining and -deleted human growth hormone receptor messenger ribonucleic acid isoforms during development.
Zogopoulos G, Figueiredo R, Jenab A, Ali Z, Lefèbvre Y, Goodyer CG
J Clin Endocrinol Metab. 1996
PubMed ID: 8636303
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A member of the CTF/NF-1 transcription factor family regulates murine growth hormone receptor gene promoter activity.
Zou L, Menon RK
Endocrinology. 1995
PubMed ID: 7588264
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Mutations of the growth hormone receptor in children with idiopathic short stature. The Growth Hormone Insensitivity Study Group.
Goddard AD, Covello R, Luoh SM, Clackson T, Attie KM, Gesundheit N, Rundle AC, Wells JA, Carlsson LM
N Engl J Med. 1995
PubMed ID: 7565946
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Decreases in growth hormone receptor signal transduction contribute to the decline in insulin-like growth factor I gene expression with age.
Xu X, Bennett SA, Ingram RL, Sonntag WE
Endocrinology. 1995
PubMed ID: 7664676
-
Growth hormone-dependent phosphorylation of tyrosine 333 and/or 338 of the growth hormone receptor.
VanderKuur JA, Wang X, Zhang L, Allevato G, Billestrup N, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7545168
-
Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation.
Allevato G, Billestrup N, Goujon L, Galsgaard ED, Norstedt G, Postel-Vinay MC, Kelly PA, Nielsen JH
J Biol Chem. 1995
PubMed ID: 7615519
-
Growth hormone (GH) receptor and GH-binding protein messenger ribonucleic acids with alternative 5'-untranslated regions are differentially expressed in mouse liver and placenta.
Southard JN, Barrett BA, Bikbulatova L, Ilkbahar Y, Wu K, Talamantes F
Endocrinology. 1995
PubMed ID: 7789316
-
Expression of exon 3-retaining and exon 3-excluding isoforms of the human growth hormone-receptor is regulated in an interindividual, rather than a tissue-specific, manner.
Wickelgren RB, Landin KL, Ohlsson C, Carlsson LM
J Clin Endocrinol Metab. 1995
PubMed ID: 7608270
-
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1.
Argetsinger LS, Hsu GW, Myers MG, Billestrup N, White MF, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7782332
-
Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor.
Frank SJ, Yi W, Zhao Y, Goldsmith JF, Gilliland G, Jiang J, Sakai I, Kraft AS
J Biol Chem. 1995
PubMed ID: 7540178
-
Cloning of the promoter-regulatory region of the murine growth hormone receptor gene. Identification of a developmentally regulated enhancer element.
Menon RK, Stephan DA, Singh M, Morris SM, Zou L
J Biol Chem. 1995
PubMed ID: 7721793
-
Growth hormone-binding protein in normal mice and in transgenic mice expressing bovine growth hormone gene.
Sotelo AI, Dominici FP, Engbers C, Bartke A, Talamantes F, Turyn D
Am J Physiol. 1995
PubMed ID: 7733275
-
Identification of four chromosomal loci determining obesity in a multifactorial mouse model.
Warden CH, Fisler JS, Shoemaker SM, Wen PZ, Svenson KL, Pace MJ, Lusis AJ
J Clin Invest. 1995
PubMed ID: 7706460
-
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
VanderKuur J, Allevato G, Billestrup N, Norstedt G, Carter-Su C
J Biol Chem. 1995
PubMed ID: 7535773
-
A single arginine residue determines species specificity of the human growth hormone receptor.
Souza SC, Frick GP, Wang X, Kopchick JJ, Lobo RB, Goodman HM
Proc Natl Acad Sci U S A. 1995
PubMed ID: 7862673
-
One class of growth hormone (GH) receptor and binding protein messenger ribonucleic acid in rat liver, GHR1, is sexually dimorphic and regulated by GH.
Baumbach WR, Bingham B
Endocrinology. 1995
PubMed ID: 7835307
-
Expression and distribution of messenger ribonucleic acids for growth hormone (GH) receptor and GH-binding protein in mice during pregnancy.
Ilkbahar YN, Wu K, Thordarson G, Talamantes F
Endocrinology. 1995
PubMed ID: 7835269
-
Fractionation of growth plate chondrocytes: differential expression of IGF-I and growth hormone and IGF-I receptor mRNA in purified populations.
Oberbauer AM, Peng R
Connect Tissue Res. 1995
PubMed ID: 15609625
-
Mouse growth hormone-binding protein and growth hormone receptor transcripts are produced from a single gene by alternative splicing.
Edens A, Southard JN, Talamantes F
Endocrinology. 1994
PubMed ID: 7988474
-
The X-ray structure of a growth hormone-prolactin receptor complex.
Somers W, Ultsch M, De Vos AM, Kossiakoff AA
Nature. 1994
PubMed ID: 7984244
-
Domains of the growth hormone receptor required for association and activation of JAK2 tyrosine kinase.
VanderKuur JA, Wang X, Zhang L, Campbell GS, Allevato G, Billestrup N, Norstedt G, Carter-Su C
J Biol Chem. 1994
PubMed ID: 8063815
-
The structure and regulation of expression of the mouse growth hormone receptor and binding protein.
Talamantes F
Proc Soc Exp Biol Med. 1994
PubMed ID: 8016161
-
Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family.
Spring J, Goldberger OA, Jenkins NA, Gilbert DJ, Copeland NG, Bernfield M
Genomics. 1994
PubMed ID: 7959737
-
Growth hormone-binding proteins: state of the art.
Baumann G
J Endocrinol. 1994
PubMed ID: 8014591
-
A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization.
Duquesnoy P, Sobrier ML, Duriez B, Dastot F, Buchanan CR, Savage MO, Preece MA, Craescu CT, Blouquit Y, Goossens M
EMBO J. 1994
PubMed ID: 8137822
-
Mapping of the genes encoding mouse thromboxane A2 receptor and prostaglandin E receptor subtypes EP2 and EP3.
Taketo M, Rochelle JM, Sugimoto Y, Namba T, Honda A, Negishi M, Ichikawa A, Narumiya S, Seldin MF
Genomics. 1994
PubMed ID: 7910583
-
An exon encoding the mouse growth hormone binding protein (mGHBP) carboxy terminus is located between exon 7 and 8 of the mouse growth hormone receptor gene.
Zhou Y, He L, Kopchick JJ
Receptor. 1994
PubMed ID: 7894338
-
Functional expression of a mouse growth hormone receptor cDNA in transfected mouse L cells.
Zhou Y, Xu B, Wang X, Chen WY, Kopchick JJ
Receptor. 1994
PubMed ID: 7529079
-
Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse.
Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ, Svenson KL, Sparkes RS, Lusis AJ
Genomics. 1993
PubMed ID: 8288233
-
The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13.
Gearing DP, Druck T, Huebner K, Overhauser J, Gilbert DJ, Copeland NG, Jenkins NA
Genomics. 1993
PubMed ID: 8276403
-
Functional characterization of the alternatively spliced, placental human growth hormone receptor.
Urbanek M, Russell JE, Cooke NE, Liebhaber SA
J Biol Chem. 1993
PubMed ID: 8360189
-
Growth hormone receptor and growth hormone-binding protein messages in mouse placenta contain the exon analogous to human exon 3.
Barnard R, Southard JN, Edens A, Talamantes F
Endocrinology. 1993
PubMed ID: 8365377
-
Diverse growth hormone receptor gene mutations in Laron syndrome.
Berg MA, Argente J, Chernausek S, Gracia R, Guevara-Aguirre J, Hopp M, Pérez-Jurado L, Rosenbloom A, Toledo SP, Francke U
Am J Hum Genet. 1993
PubMed ID: 8488849
-
Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome.
Amselem S, Duquesnoy P, Duriez B, Dastot F, Sobrier ML, Valleix S, Goossens M
Hum Mol Genet. 1993
PubMed ID: 8504296
-
Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.
Edery M, Rozakis-Adcock M, Goujon L, Finidori J, Lévi-Meyrueis C, Paly J, Djiane J, Postel-Vinay MC, Kelly PA
J Clin Invest. 1993
PubMed ID: 8450064
-
Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome.
Kou K, Lajara R, Rotwein P
J Clin Endocrinol Metab. 1993
PubMed ID: 8421103
-
Characterization of the short isoform of the growth hormone receptor synthesized by rat adipocytes.
Frick GP, Goodman HM
Endocrinology. 1992
PubMed ID: 1446642
-
Variants of the 5'-untranslated sequence of human growth hormone receptor mRNA.
Pekhletsky RI, Chernov BK, Rubtsov PM
Mol Cell Endocrinol. 1992
PubMed ID: 1301391
-
Activation of the prolactin receptor gene by promoter insertion in a Moloney murine leukemia virus-induced rat thymoma.
Barker CS, Bear SE, Keler T, Copeland NG, Gilbert DJ, Jenkins NA, Yeung RS, Tsichlis PN
J Virol. 1992
PubMed ID: 1404614
-
Expression of the growth hormone receptor and growth hormone-binding protein during pregnancy in the mouse.
Cramer SD, Barnard R, Engbers C, Ogren L, Talamantes F
Endocrinology. 1992
PubMed ID: 1639029
-
An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere.
Brannan CI, Gilbert DJ, Ceci JD, Matsuda Y, Chapman VM, Mercer JA, Eisen H, Johnston LA, Copeland NG, Jenkins NA
Genomics. 1992
PubMed ID: 1354638
-
Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.
Urbanek M, MacLeod JN, Cooke NE, Liebhaber SA
Mol Endocrinol. 1992
PubMed ID: 1569971
-
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
de Vos AM, Ultsch M, Kossiakoff AA
Science. 1992
PubMed ID: 1549776
-
Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome.
Berg MA, Guevara-Aguirre J, Rosenbloom AL, Rosenfeld RG, Francke U
Hum Mutat. 1992
PubMed ID: 1284474
-
Binding of human growth hormone (GH)-variant (placental GH) to GH-binding proteins in human plasma.
Baumann G, Dávila N, Shaw MA, Ray J, Liebhaber SA, Cooke NE
J Clin Endocrinol Metab. 1991
PubMed ID: 1955498
-
Recurrent nonsense mutations in the growth hormone receptor from patients with Laron dwarfism.
Amselem S, Sobrier ML, Duquesnoy P, Rappaport R, Postel-Vinay MC, Gourmelen M, Dallapiccola B, Goossens M
J Clin Invest. 1991
PubMed ID: 1999489
-
Growth hormone receptor (Ghr) and hemoglobin alpha-chain pseudogene 3 (Hba-ps3) map proximal to the myelocytomatosis oncogene (Myc) on mouse chromosome 15.
Eicher EM, Lee BK
Mamm Genome. 1991
PubMed ID: 1794046
-
The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.
Fuh G, Mulkerrin MG, Bass S, McFarland N, Brochier M, Bourell JH, Light DR, Wells JA
J Biol Chem. 1990
PubMed ID: 2406245
-
The receptors for prolactin and growth hormone are localized in the same region of human chromosome 5.
Arden KC, Boutin JM, Djiane J, Kelly PA, Cavenee WK
Cytogenet Cell Genet. 1990
PubMed ID: 2369845
-
Laron dwarfism and mutations of the growth hormone-receptor gene.
Amselem S, Duquesnoy P, Attree O, Novelli G, Bousnina S, Postel-Vinay MC, Goossens M
N Engl J Med. 1989
PubMed ID: 2779634
-
Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
Godowski PJ, Leung DW, Meacham LR, Galgani JP, Hellmiss R, Keret R, Rotwein PS, Parks JS, Laron Z, Wood WI
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2813379
-
The growth hormone-binding protein in rat serum is an alternatively spliced form of the rat growth hormone receptor.
Baumbach WR, Horner DL, Logan JS
Genes Dev. 1989
PubMed ID: 2792761
-
Regulation of rat growth hormone receptor gene expression.
Mathews LS, Enberg B, Norstedt G
J Biol Chem. 1989
PubMed ID: 2722883
-
Mouse serum growth hormone (GH) binding protein has GH receptor extracellular and substituted transmembrane domains.
Smith WC, Kuniyoshi J, Talamantes F
Mol Endocrinol. 1989
PubMed ID: 2739661
-
Ultrastructural study of the response of eosinophil granule cells to Aeromonas salmonicida extracellular products and histamine liberators in rainbow trout Salmo gairdneri Richardson.
Vallejo AN, Ellis AE
Dev Comp Immunol. 1989
PubMed ID: 2776934
-
Chromosome mapping of the growth hormone receptor gene in man and mouse.
Barton DE, Foellmer BE, Wood WI, Francke U
Cytogenet Cell Genet. 1989
PubMed ID: 2776481
-
Detection of two growth hormone receptor mRNAs and primary translation products in the mouse.
Smith WC, Linzer DI, Talamantes F
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3200842
-
Isolation of two molecular weight variants of the mouse growth hormone receptor.
Smith WC, Colosi P, Talamantes F
Mol Endocrinol. 1988
PubMed ID: 3398846
-
Growth hormone receptor and serum binding protein: purification, cloning and expression.
Leung DW, Spencer SA, Cachianes G, Hammonds RG, Collins C, Henzel WJ, Barnard R, Waters MJ, Wood WI
Nature. 1987
PubMed ID: 2825030
-
Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse.
Herington AC, Harrison D, Graystone J
Endocrinology. 1983
PubMed ID: 6303755
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