Home GCK
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(Human) GRCh37 - chr7:44183870..44237769 (53.90 kb) View in Genome Browser
(Mouse) NCBIM37 - chr11:5800823..5850084 (49.26 kb) View in Genome Browser
(Rat) RGSC3.4 - chr14:86572518..86587740 (15.22 kb) View in Genome Browser
HaemAtlas Expression Table for GCK:|
Expression Legend
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Cell Types Showing Expression: Available
Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.
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| ductal cells | exocrine pancreas | pancreatic islets | primary beta cells | Pancreatic Islets MPSS | beta cell line | pancreatic islets | whole pancreas | alpha cell | beta cell line | pancreatic islets | primary beta cells | whole pancreas |
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The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues.
A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.
Tissues Showing Expression: Available
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| Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Interactions Table for GCK:The GCK interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction.
The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources.
| Interactor | Interactor | Sources | Classification | Pubmed IDs |
| GCK | GCKR | HPRD, MINT, IntAct, Reactome | empirical | 9000692 8626423 10601273 11473043 16542652 11522786 14627435 |
| GCK | GLUD1 | MINT | empirical | 16542652 |
| GCK | INS | HPRD | empirical | 12101177 |
| GCK | PFKFB1 | IntAct | empirical | 11522786 |
| GCK | PFKFB2 | HPRD | empirical | 11522786 |
| GCK | PFKFB3 | IntAct | empirical | 11522786 |
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Type 1 Diabetes Publications: 132
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UCP2 mRNA expression is dependent on glucose metabolism in pancreatic islets.
Dalgaard LT
Biochem Biophys Res Commun. 2012
PubMed ID: 22177951
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The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
Medina MC, Molina J, Gadea Y, Fachado A, Murillo M, Simovic G, Pileggi A, Hernández A, Edlund H, Bianco AC
Endocrinology. 2011
PubMed ID: 21828183
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Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes.
Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y
J Biol Chem. 2011
PubMed ID: 21613229
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Glucagon-like Peptide 1 Stimulates Post-translational Activation of Glucokinase in Pancreatic {beta} Cells.
Ding SY, Nkobena A, Kraft CA, Markwardt ML, Rizzo MA
J Biol Chem. 2011
PubMed ID: 21454584
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Four novel cases of permanent neonatal diabetes mellitus caused by homozygous mutations in the glucokinase gene.
Bennett K, James C, Mutair A, Al-Shaikh H, Sinani A, Hussain K
Pediatr Diabetes. 2011
PubMed ID: 21518409
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Control of pancreatic β cell regeneration by glucose metabolism.
Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y
Cell Metab. 2011
PubMed ID: 21459328
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Phenotype variability and neonatal diabetes in a large family with heterozygous mutation of the glucokinase gene.
Borowiec M, Mysliwiec M, Fendler W, Antosik K, Brandt A, Malecki M, Mlynarski W
Acta Diabetol. 2011
PubMed ID: 21437567
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Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice.
Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y
Diabetes. 2011
PubMed ID: 21330637
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Chronic ethanol consumption-induced pancreatic {beta}-cell dysfunction and apoptosis through glucokinase nitration and its down-regulation.
Kim JY, Song EH, Lee HJ, Oh YK, Park YS, Park JW, Kim BJ, Kim DJ, Lee I, Song J, Kim WH
J Biol Chem. 2010
PubMed ID: 20855893
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Insight into the biochemical characteristics of a novel glucokinase gene mutation.
Shen Y, Cai M, Liang H, Wang H, Weng J
Hum Genet. 2010
PubMed ID: 21104275
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Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
Valtat B, Dupuis C, Zenaty D, Singh-Estivalet A, Tronche F, Bréant B, Blondeau B
Diabetologia. 2010
PubMed ID: 20857084
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Endogenous Activation of Glucokinase by 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase Is Glucose Dependent.
Langer S, Kaminski MT, Lenzen S, Baltrusch S
Mol Endocrinol. 2010
PubMed ID: 20702580
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The transcription factor Rfx3 regulates {beta}-cell differentiation, function and glucokinase expression.
Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W
Diabetes. 2010
PubMed ID: 20413507
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JR, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day IN, de Geus EJ, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen AL, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PR, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, DIAGRAM Consortium, GIANT Consortium, Global BPgen Consortium, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Anders Hamsten on behalf of Procardis Consortium, MAGIC investigators, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I
Nat Genet. 2010
PubMed ID: 20081858
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Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
Tam CH, Ho JS, Wang Y, Lee HM, Lam VK, Germer S, Martin M, So WY, Ma RC, Chan JC, Ng MC
PLoS One. 2010
PubMed ID: 20628598
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Glial glucokinase expression in adult and post-natal development of the hypothalamic region.
Millán C, Martínez F, Cortés-Campos C, Lizama I, Yañez MJ, Llanos P, Reinicke K, Rodríguez F, Peruzzo B, Nualart F, García MA
ASN Neuro. 2010
PubMed ID: 20531973
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Naturally occurring glucokinase mutations are associated with defects in posttranslational S-nitrosylation.
Ding SY, Tribble ND, Kraft CA, Markwardt M, Gloyn AL, Rizzo MA
Mol Endocrinol. 2010
PubMed ID: 19934346
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Phenotypic and Pathomorphological Characteristics of a Novel Mutant Mouse Model for Maturity-Onset Diabetes of the Young Type 2 (MODY 2).
van Buerck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N
Am J Physiol Endocrinol Metab. 2009
PubMed ID: 19952346
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Gestational high-fat programming impairs insulin release and reduces Pdx-1 and glucokinase immunoreactivity in neonatal Wistar rats.
Cerf ME, Chapman CS, Muller CJ, Louw J
Metabolism. 2009
PubMed ID: 19604517
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Opposite Clinical Phenotypes of Glucokinase Disease: Description of a Novel Activating Mutation and Contiguous Inactivating Mutations in Human Glucokinase (GCK) Gene.
Barbetti F, Cobo-Vuilleumier N, Dionisi-Vici C, Toni S, Ciampalini P, Massa O, Rodriguez-Bada P, Colombo C, Lenzi L, Garcia-Gimeno MA, Bermudez-Silva FJ, Rodriguez de Fonseca F, Banin P, Aledo JC, Baixeras E, Sanz P, Cuesta-Muñoz AL
Mol Endocrinol. 2009
PubMed ID: 19884385
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The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.
Beer NL, Tribble ND, McCulloch LJ, Roos C, Johnson PR, Orho-Melander M, Gloyn AL
Hum Mol Genet. 2009
PubMed ID: 19643913
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Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia.
Osbak KK, Colclough K, Saint-Martin C, Beer NL, Bellanné-Chantelot C, Ellard S, Gloyn AL
Hum Mutat. 2009
PubMed ID: 19790256
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Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS).
Kelliny C, Ekelund U, Bo Andersen L, Brage S, Loos RJ, Wareham NJ, Langenberg C
Diabetes. 2009
PubMed ID: 19741166
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ADDITIVE EFFECTS OF GENETIC VARIATION IN GCK AND G6PC2 ON INSULIN SECRETION AND FASTING GLUCOSE.
Li X, Shu YH, Xiang AH, Trigo E, Kuusisto J, Hartiala J, Swift AJ, Kawakubo M, Stringham HM, Bonnycastle LL, Lawrence JM, Laakso M, Allayee H, Buchanan TA, Watanabe RM
Diabetes. 2009
PubMed ID: 19741163
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Characterization of glucokinase polymorphisms associated with maturity-onset diabetes of the young (MODY2) in Jordanian population.
Al-Sheyab F, Khamaiseh E, Halaweh MA, Khaul RW
Tsitol Genet. 2009
PubMed ID: 20458967
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Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets.
Vilches-Flores A, Tovar AR, Marin-Hernandez A, Rojas-Ochoa A, Fernandez-Mejia C
J Nutr Biochem. 2009
PubMed ID: 19560332
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Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, Nijpels G, Maassen JA, Dekker JM, 't Hart LM
Diabetologia. 2009
PubMed ID: 19533084
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An infant with combination gene mutations for Monogenic Diabetes of Youth (MODY) 2 and 4, presenting with Diabetes Mellitus Requiring Insulin (DMRI) at 8 months of age.
Odem J, Munzinger E, Violand S, Morlan AV, Rife D, Bachrach B
Pediatr Diabetes. 2009
PubMed ID: 19515026
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Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.
Sayed S, Langdon DR, Odili S, Chen P, Buettger C, Schiffman AB, Suchi M, Taub R, Grimsby J, Matschinsky FM, Stanley CA
Diabetes. 2009
PubMed ID: 19336674
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Identification of a novel {beta}-cell glucokinase (GCK) promoter mutation (-71G>C) which modulates GCK gene expression through loss of allele-specific Sp1 binding causing mild fasting hyperglycaemia in humans.
Gasperíková D, Tribble ND, Staník J, Hucková M, Misovicová N, van de Bunt M, Valentínová L, Barrow BA, Barák L, Dobránsky R, Bereczková E, Michálek J, Wicks K, Colclough K, Knight JC, Ellard S, Klimes I, Gloyn AL
Diabetes. 2009
PubMed ID: 19411616
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Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population.
Qi Q, Wu Y, Li H, Loos RJ, Hu FB, Sun L, Lu L, Pan A, Liu C, Wu H, Chen L, Yu Z, Lin X
Diabetologia. 2009
PubMed ID: 19241058
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Identification of eight new mutations in the GCK gene by DHPLC screening in a Spanish population.
Solera J, Arias P, Amiñoso C, González-Casado I, Garre P, Herranz L, Villarroel A, Cruz M, Jáñez M, Pallardo LF, Gracia R
Diabetes Res Clin Pract. 2009
PubMed ID: 19410318
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Hepatic glucokinase activity is the primary defect in alloxan-induced diabetes of mice.
Zhang X, Liang W, Mao Y, Li H, Yang Y, Tan H
Biomed Pharmacother. 2009
PubMed ID: 17768029
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The "A-{beta}-" subtype of Ketosis-Prone Diabetes (KPD) is not predominantly a monogenic diabetic syndrome.
Haaland WC, Scaduto DI, Maldonado MR, Mansouri DL, Nalini R, Iyer D, Patel S, Guthikonda A, Hampe CS, Balasubramanyam A, Metzker ML
Diabetes Care. 2009
PubMed ID: 19228875
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Retinoids synergize with insulin to induce hepatic Gck Expression.
Chen G, Zhang Y, Lu D, Li NQ, Ross AC
Biochem J. 2009
PubMed ID: 19173678
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Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.
Ezzidi I, Mtiraoui N, Cauchi S, Vaillant E, Dechaume A, Chaieb M, Kacem M, Almawi WY, Froguel P, Mahjoub T, Vaxillaire M
BMC Med Genet. 2009
PubMed ID: 19368707
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Variants in MTNR1B influence fasting glucose levels.
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, Kaakinen M, Lyssenko V, Chen WM, Ahmadi K, Beckmann JS, Bergman RN, Bochud M, Bonnycastle LL, Buchanan TA, Cao A, Cervino A, Coin L, Collins FS, Crisponi L, de Geus EJ, Dehghan A, Deloukas P, Doney AS, Elliott P, Freimer N, Gateva V, Herder C, Hofman A, Hughes TE, Hunt S, Illig T, Inouye M, Isomaa B, Johnson T, Kong A, Krestyaninova M, Kuusisto J, Laakso M, Lim N, Lindblad U, Lindgren CM, McCann OT, Mohlke KL, Morris AD, Naitza S, Orrù M, Palmer CN, Pouta A, Randall J, Rathmann W, Saramies J, Scheet P, Scott LJ, Scuteri A, Sharp S, Sijbrands E, Smit JH, Song K, Steinthorsdottir V, Stringham HM, Tuomi T, Tuomilehto J, Uitterlinden AG, Voight BF, Waterworth D, Wichmann HE, Willemsen G, Witteman JC, Yuan X, Zhao JH, Zeggini E, Schlessinger D, Sandhu M, Boomsma DI, Uda M, Spector TD, Penninx BW, Altshuler D, Vollenweider P, Jarvelin MR, Lakatta E, Waeber G, Fox CS, Peltonen L, Groop LC, Mooser V, Cupples LA, Thorsteinsdottir U, Boehnke M, Barroso I, Van Duijn C, Dupuis J, Watanabe RM, Stefansson K, McCarthy MI, Wareham NJ, Meigs JB, Abecasis GR
Nat Genet. 2009
PubMed ID: 19060907
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Impact of Small Molecule Glucokinase Activator on Glucose Metabolism and Beta Cell Mass.
Nakamura A, Terauchi Y, Ohyama S, Kubota J, Shimazaki H, Nambu T, Takamoto I, Kubota N, Eiki J, Yoshioka N, Kadowaki T, Koike T
Endocrinology. 2008
PubMed ID: 19008318
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HNF1alpha mutations are present in half of clinically defined MODY patients in South-Brazilian individuals.
Maraschin Jde F, Kannengiesser C, Murussi N, Campagnolo N, Canani LH, Gross JL, Velho G, Grandchamp B, Silveiro SP
Arq Bras Endocrinol Metabol. 2008
PubMed ID: 19169489
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Biophysical characterization of the interaction between hepatic glucokinase and its regulatory protein - impact of physiological and pharmacological effectors.
Anderka O, Boyken J, Aschenbach U, Batzer A, Boscheinen O, Schmoll D
J Biol Chem. 2008
PubMed ID: 18809676
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Adaptation of Glucokinase Gene Expression in the Rat Dorsal Vagal Complex in a Model for Recurrent Intermediate Insulin-Induced Hypoglycemia: Impact of Gender.
Genabai NK, Vavaiya KV, Briski KP
J Mol Neurosci. 2008
PubMed ID: 18612599
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Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy.
Turkkahraman D, Bircan I, Tribble ND, Akçurin S, Ellard S, Gloyn AL
J Pediatr. 2008
PubMed ID: 18571549
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Human pancreatic beta-cell glucokinase: subcellular localization and glucose repression signalling function in the yeast cell.
Riera A, Ahuatzi D, Herrero P, Garcia-Gimeno MA, Sanz P, Moreno F
Biochem J. 2008
PubMed ID: 18588509
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Identification of transcripts with enriched expression in the developing and adult pancreas.
Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones S, Marra MA, Helgason CD
Genome Biol. 2008
PubMed ID: 18554416
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Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene.
Rubio-Cabezas O, Díaz González F, Aragonés A, Argente J, Campos-Barros A
Pediatr Diabetes. 2008
PubMed ID: 18298419
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The role of the transcription factor Sox4 in insulin secretion and impaired glucose tolerance.
Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD
Diabetes. 2008
PubMed ID: 18477811
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Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry.
Sagen JV, Bjørkhaug L, Molnes J, Ræder H, Grevle L, Søvik O, Molven A, Njølstad PR
Pediatr Diabetes. 2008
PubMed ID: 18399931
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A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.
Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L
Biochem J. 2008
PubMed ID: 18039179
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Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ
Nat Med. 2008
PubMed ID: 18223655
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The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.
Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AP, Nielsen AL, Albrechtsen A, Rasmussen SS, Jørgensen T, Borch-Johnsen K, Sandbæk A, Lauritzen T, Madsbad S, Hansen T, Pedersen O
Diabetologia. 2008
PubMed ID: 18008060
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Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules.
Schinner S, Ulgen F, Papewalis C, Schott M, Woelk A, Vidal-Puig A, Scherbaum WA
Diabetologia. 2008
PubMed ID: 17994217
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Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.
Wabitsch M, Lahr G, Van de Bunt M, Marchant C, Lindner M, von Puttkamer J, Fenneberg A, Debatin KM, Klein R, Ellard S, Clark A, Gloyn AL
Diabet Med. 2007
PubMed ID: 17976205
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Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation.
Bjørkhaug L, Molnes J, Søvik O, Njølstad PR, Flatmark T
J Biol Chem. 2007
PubMed ID: 17561510
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Circadian and age-dependent expression patterns of GLUT2 and glucokinase in the pancreatic beta-cell of diabetic and nondiabetic rats.
Frese T, Bazwinsky I, Mühlbauer E, Peschke E
Horm Metab Res. 2007
PubMed ID: 17712721
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Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.
Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L
Diabetes. 2007
PubMed ID: 17389332
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Pancreatic glucokinase is activated by insulin-like growth factor-I.
Yoshida K, Murao K, Imachi H, Cao WM, Yu X, Li J, Ahmed RA, Kitanaka N, Wong NC, Unterman TG, Magnuson MA, Ishida T
Endocrinology. 2007
PubMed ID: 17317782
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Glucokinase thermolability and hepatic regulatory protein binding are essential factors for predicting the blood glucose phenotype of missense mutations.
Pino MF, Kim KA, Shelton KD, Lindner J, Odili S, Li C, Collins HW, Shiota M, Matschinsky FM, Magnuson MA
J Biol Chem. 2007
PubMed ID: 17353190
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Novel insights into the regulation of the bound and diffusible glucokinase in MIN6 beta-cells.
Baltrusch S, Lenzen S
Diabetes. 2007
PubMed ID: 17287461
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MafB is required for islet beta cell maturation.
Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360442
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BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H
Cell Metab. 2007
PubMed ID: 17339028
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The long-term impact on offspring of exposure to hyperglycaemia in utero due to maternal glucokinase gene mutations.
Singh R, Pearson ER, Clark PM, Hattersley AT
Diabetologia. 2007
PubMed ID: 17216282
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Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase activity.
García-Herrero CM, Galán M, Vincent O, Flández B, Gargallo M, Delgado-Alvarez E, Blázquez E, Navas MA
Diabetologia. 2007
PubMed ID: 17186219
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Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.
Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T
J Clin Invest. 2007
PubMed ID: 17200721
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An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.
Futamura M, Hosaka H, Kadotani A, Shimazaki H, Sasaki K, Ohyama S, Nishimura T, Eiki J, Nagata Y
J Biol Chem. 2006
PubMed ID: 17028192
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Glucokinase mutations in young children with hyperglycemia.
Codner E, Deng L, Pérez-Bravo F, Román R, Lanzano P, Cassorla F, Chung WK
Diabetes Metab Res Rev. 2006
PubMed ID: 16444761
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Common variants in MODY genes increase the risk of gestational diabetes mellitus.
Shaat N, Karlsson E, Lernmark A, Ivarsson S, Lynch K, Parikh H, Almgren P, Berntorp K, Groop L
Diabetologia. 2006
PubMed ID: 16752173
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Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.
Galán M, Vincent O, Roncero I, Azriel S, Boix-Pallares P, Delgado-Alvarez E, Díaz-Cadórniga F, Blázquez E, Navas MA
Biochem J. 2006
PubMed ID: 16173921
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A -30G>A polymorphism of the beta-cell-specific glucokinase promoter associates with hyperglycemia in the general population of whites.
Rose CS, Ek J, Urhammer SA, Glümer C, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T
Diabetes. 2005
PubMed ID: 16186409
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Half of clinically defined maturity-onset diabetes of the young patients in Denmark do not have mutations in HNF4A, GCK, and TCF1.
Johansen A, Ek J, Mortensen HB, Pedersen O, Hansen T
J Clin Endocrinol Metab. 2005
PubMed ID: 15928245
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Identification of novel GCK and HNF1A/TCF1 mutations and polymorphisms in German families with maturity-onset diabetes of the young (MODY).
Toaima D, Näke A, Wendenburg J, Praedicow K, Rohayem J, Engel K, Galler A, Gahr M, Lee-Kirsch MA
Hum Mutat. 2005
PubMed ID: 15841481
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Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.
Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM
J Biol Chem. 2005
PubMed ID: 15677479
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A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice.
Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldsworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD
Diabetologia. 2005
PubMed ID: 15729571
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Developmental expression of glucokinase in rat hypothalamus.
Sutherland VL, McReynolds M, Tompkins LS, Brooks HL, Lynch RM
Brain Res Dev Brain Res. 2005
PubMed ID: 15707679
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Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene.
Weedon MN, Frayling TM, Shields B, Knight B, Turner T, Metcalf BS, Voss L, Wilkin TJ, McCarthy A, Ben-Shlomo Y, Davey Smith G, Ring S, Jones R, Golding J, Byberg L, Mann V, Axelsson T, Syvänen AC, Leon D, Hattersley AT
Diabetes. 2005
PubMed ID: 15677518
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Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L
Transgenic Res. 2004
PubMed ID: 15587270
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Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.
Arden C, Harbottle A, Baltrusch S, Tiedge M, Agius L
Diabetes. 2004
PubMed ID: 15331544
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Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Cuesta-Muñoz AL, Huopio H, Otonkoski T, Gomez-Zumaquero JM, Näntö-Salonen K, Rahier J, López-Enriquez S, García-Gimeno MA, Sanz P, Soriguer FC, Laakso M
Diabetes. 2004
PubMed ID: 15277402
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G(-30)A polymorphism in the pancreatic promoter of the glucokinase gene associated with angiographic coronary artery disease and type 2 diabetes mellitus.
März W, Nauck M, Hoffmann MM, Nagel D, Boehm BO, Koenig W, Rothenbacher D, Winkelmann BR
Circulation. 2004
PubMed ID: 15173029
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A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.
Inoue M, Sakuraba Y, Motegi H, Kubota N, Toki H, Matsui J, Toyoda Y, Miwa I, Terauchi Y, Kadowaki T, Shigeyama Y, Kasuga M, Adachi T, Fujimoto N, Matsumoto R, Tsuchihashi K, Kagami T, Inoue A, Kaneda H, Ishijima J, Masuya H, Suzuki T, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T
Hum Mol Genet. 2004
PubMed ID: 15102714
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Third ventricular alloxan reversibly impairs glucose counterregulatory responses.
Sanders NM, Dunn-Meynell AA, Levin BE
Diabetes. 2004
PubMed ID: 15111491
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Glucokinase (GCK) mutations in hyper- and hypoglycemia: maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemia of infancy.
Gloyn AL
Hum Mutat. 2003
PubMed ID: 14517946
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Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Gloyn AL, Noordam K, Willemsen MA, Ellard S, Lam WW, Campbell IW, Midgley P, Shiota C, Buettger C, Magnuson MA, Matschinsky FM, Hattersley AT
Diabetes. 2003
PubMed ID: 12941786
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Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase.
Rizzo MA, Piston DW
J Cell Biol. 2003
PubMed ID: 12707306
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A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin.
Rizzo MA, Magnuson MA, Drain PF, Piston DW
J Biol Chem. 2002
PubMed ID: 12101177
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Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6.
Lannoy VJ, Decaux JF, Pierreux CE, Lemaigre FP, Rousseau GG
Diabetologia. 2002
PubMed ID: 12189444
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Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML
Nat Genet. 2002
PubMed ID: 11912494
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Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus.
Weng J, Ekelund M, Lehto M, Li H, Ekberg G, Frid A, Aberg A, Groop LC, Berntorp K
Diabetes Care. 2002
PubMed ID: 11772903
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Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.
Baltrusch S, Lenzen S, Okar DA, Lange AJ, Tiedge M
J Biol Chem. 2001
PubMed ID: 11522786
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Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression.
Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, Rodriguez-Dorantes M, Romero-Navarro G, Matschinsky FM, Wang J, German MS
Endocrinology. 2001
PubMed ID: 11250924
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Cell-specific roles of glucokinase in glucose homeostasis.
Postic C, Shiota M, Magnuson MA
Recent Prog Horm Res. 2001
PubMed ID: 11237213
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beta-cell glucokinase deficiency and hyperglycemia are associated with reduced islet amyloid deposition in a mouse model of type 2 diabetes.
Andrikopoulos S, Verchere CB, Terauchi Y, Kadowaki T, Kahn SE
Diabetes. 2000
PubMed ID: 11118007
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Characterization of glucokinase regulatory protein-deficient mice.
Grimsby J, Coffey JW, Dvorozniak MT, Magram J, Li G, Matschinsky FM, Shiota C, Kaur S, Magnuson MA, Grippo JF
J Biol Chem. 2000
PubMed ID: 10713097
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Hepatic glucokinase promoter polymorphism is associated with hepatic insulin resistance in Asian Indians.
Chiu KC, Chuang LM, Yoon C, Saad MF
BMC Genet. 2000
PubMed ID: 11112984
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Insulin effect during embryogenesis determines fetal growth: a possible molecular link between birth weight and susceptibility to type 2 diabetes.
Terauchi Y, Kubota N, Tamemoto H, Sakura H, Nagai R, Akanuma Y, Kimura S, Kadowaki T
Diabetes. 2000
PubMed ID: 10615953
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Molecular genetics of diabetes mellitus in Chinese subjects: identification of mutations in glucokinase and hepatocyte nuclear factor-1alpha genes in patients with early-onset type 2 diabetes mellitus/MODY.
Ng MC, Cockburn BN, Lindner TH, Yeung VT, Chow CC, So WY, Li JK, Lo YM, Lee ZS, Cockram CS, Critchley JA, Bell GI, Chan JC
Diabet Med. 1999
PubMed ID: 10588527
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Adenovirus-mediated knockout of a conditional glucokinase gene in isolated pancreatic islets reveals an essential role for proximal metabolic coupling events in glucose-stimulated insulin secretion.
Piston DW, Knobel SM, Postic C, Shelton KD, Magnuson MA
J Biol Chem. 1999
PubMed ID: 9873043
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Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase.
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA
J Biol Chem. 1999
PubMed ID: 9867845
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Nutrient-dependent distribution of insulin and glucokinase immunoreactivities in rat pancreatic beta cells.
Jörns A, Tiedge M, Lenzen S
Virchows Arch. 1999
PubMed ID: 10071239
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Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Sakura H, Ashcroft SJ, Terauchi Y, Kadowaki T, Ashcroft FM
Diabetologia. 1998
PubMed ID: 9662046
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Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS
Development. 1998
PubMed ID: 9584121
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Organization of the human glucokinase regulator gene GCKR.
Hayward BE, Dunlop N, Intody S, Leek JP, Markham AF, Warner JP, Bonthron DT
Genomics. 1998
PubMed ID: 9570959
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Glucokinase is located in secretory granules of pancreatic D-cells.
Toyoda Y, Yoshie S, Fujita T, Ito Y, Nonogaki T, Miwa I
FEBS Lett. 1997
PubMed ID: 9357983
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Abnormal regulation of HGP by hyperglycemia in mice with a disrupted glucokinase allele.
Rossetti L, Chen W, Hu M, Hawkins M, Barzilai N, Efrat S
Am J Physiol. 1997
PubMed ID: 9357804
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Glucose-6-phosphatase structure, regulation, and function: an update.
Foster JD, Pederson BA, Nordlie RC
Proc Soc Exp Biol Med. 1997
PubMed ID: 9270716
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Co-localization of glucokinase with actin filaments.
Murata T, Katagiri H, Ishihara H, Shibasaki Y, Asano T, Toyoda Y, Pekiner B, Pekiner C, Miwa I, Oka Y
FEBS Lett. 1997
PubMed ID: 9109397
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Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease.
Terauchi Y, Iwamoto K, Tamemoto H, Komeda K, Ishii C, Kanazawa Y, Asanuma N, Aizawa T, Akanuma Y, Yasuda K, Kodama T, Tobe K, Yazaki Y, Kadowaki T
J Clin Invest. 1997
PubMed ID: 9062343
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Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus.
Brown KS, Kalinowski SS, Megill JR, Durham SK, Mookhtiar KA
Diabetes. 1997
PubMed ID: 9000692
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Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene.
Aizawa T, Asanuma N, Terauchi Y, Suzuki N, Komatsu M, Itoh N, Nakabayashi T, Hidaka H, Ohnota H, Yamauchi K, Yasuda K, Yazaki Y, Kadowaki T, Hashizume K
Biochem Biophys Res Commun. 1996
PubMed ID: 8954920
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Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
Velho G, Petersen KF, Perseghin G, Hwang JH, Rothman DL, Pueyo ME, Cline GW, Froguel P, Shulman GI
J Clin Invest. 1996
PubMed ID: 8878425
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Mitochondria and diabetes. Genetic, biochemical, and clinical implications of the cellular energy circuit.
Gerbitz KD, Gempel K, Brdiczka D
Diabetes. 1996
PubMed ID: 8549853
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Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose.
Terauchi Y, Sakura H, Yasuda K, Iwamoto K, Takahashi N, Ito K, Kasai H, Suzuki H, Ueda O, Kamada N
J Biol Chem. 1995
PubMed ID: 8530440
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Partial structure of the mouse glucokinase gene.
Ishimura-Oka K, Nakamuta M, Chu MJ, Sullivan M, Chan L, Oka K
Genomics. 1995
PubMed ID: 8575769
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Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites.
Postic C, Niswender KD, Decaux JF, Parsa R, Shelton KD, Gouhot B, Pettepher CC, Granner DK, Girard J, Magnuson MA
Genomics. 1995
PubMed ID: 8575768
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Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis.
Grupe A, Hultgren B, Ryan A, Ma YH, Bauer M, Stewart TA
Cell. 1995
PubMed ID: 7553875
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Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene.
Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N
J Biol Chem. 1995
PubMed ID: 7665557
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Inhibition of pancreatic beta-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance.
Ishihara H, Tashiro F, Ikuta K, Asano T, Katagiri H, Inukai K, Kikuchi M, Yazaki Y, Oka Y, Miyazaki J
FEBS Lett. 1995
PubMed ID: 7556622
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Molecular model of human beta-cell glucokinase built by analogy to the crystal structure of yeast hexokinase B.
St Charles R, Harrison RW, Bell GI, Pilkis SJ, Weber IT
Diabetes. 1994
PubMed ID: 8194664
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Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.
Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N
Proc Natl Acad Sci U S A. 1994
PubMed ID: 7510884
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Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
Takeda J, Gidh-Jain M, Xu LZ, Froguel P, Velho G, Vaxillaire M, Cohen D, Shimada F, Makino H, Nishi S
J Biol Chem. 1993
PubMed ID: 8325892
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Two microsatellite repeat polymorphisms flanking opposite ends of the human glucokinase gene: use in haplotype analysis of Welsh Caucasians with type 2 (non-insulin-dependent) diabetes mellitus.
Tanizawa Y, Chiu KC, Province MA, Morgan R, Owens DR, Rees A, Permutt MA
Diabetologia. 1993
PubMed ID: 8314445
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Glucokinase gene variants in the common form of NIDDM.
Chiu KC, Tanizawa Y, Permutt MA
Diabetes. 1993
PubMed ID: 8454109
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Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus.
Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, Sun F, Lesage S, Stoffel M, Takeda J, Passa P
N Engl J Med. 1993
PubMed ID: 8433729
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Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Gidh-Jain M, Takeda J, Xu LZ, Lange AJ, Vionnet N, Stoffel M, Froguel P, Velho G, Sun F, Cohen D
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8446612
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Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus.
Katagiri H, Asano T, Ishihara H, Inukai K, Anai M, Miyazaki J, Tsukuda K, Kikuchi M, Yazaki Y, Oka Y
Lancet. 1992
PubMed ID: 1360036
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Glucokinase and NIDDM. A candidate gene that paid off.
Permutt MA, Chiu KC, Tanizawa Y
Diabetes. 1992
PubMed ID: 1397713
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Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus.
Stoffel M, Froguel P, Takeda J, Zouali H, Vionnet N, Nishi S, Weber IT, Harrison RW, Pilkis SJ, Lesage S
Proc Natl Acad Sci U S A. 1992
PubMed ID: 1502186
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Human pancreatic beta-cell glucokinase: cDNA sequence and localization of the polymorphic gene to chromosome 7, band p 13.
Nishi S, Stoffel M, Xiang K, Shows TB, Bell GI, Takeda J
Diabetologia. 1992
PubMed ID: 1511800
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Human islet glucokinase gene. Isolation and sequence analysis of full-length cDNA.
Koranyi LI, Tanizawa Y, Welling CM, Rabin DU, Permutt MA
Diabetes. 1992
PubMed ID: 1612194
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Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism.
Tanizawa Y, Matsutani A, Chiu KC, Permutt MA
Mol Endocrinol. 1992
PubMed ID: 1354840
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Linkage of type 2 diabetes to the glucokinase gene.
Hattersley AT, Turner RC, Permutt MA, Patel P, Tanizawa Y, Chiu KC, O'Rahilly S, Watkins PJ, Wainscoat JS
Lancet. 1992
PubMed ID: 1349989
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Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.
Hughes SD, Quaade C, Milburn JL, Cassidy L, Newgard CB
J Biol Chem. 1991
PubMed ID: 1999433
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An alternate promoter in the glucokinase gene is active in the pancreatic beta cell.
Magnuson MA, Shelton KD
J Biol Chem. 1989
PubMed ID: 2550428
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Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
Fenner D, Odili S, Hong HK, Kobayashi Y, Kohsaka A, Siepka SM, Vitaterna MH, Chen P, Zelent B, Grimsby J, Takahashi JS, Matschinsky FM, Bass J
J Biol Chem. 2011
PubMed ID: 21921030
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MODY type 2 in Greig cephalopolysyndactyly syndrome (GCPS) as part of a contiguous gene deletion syndrome.
Zung A, Petek E, Ben-Zeev B, Schwarzbraun T, Ben-Yehoshua SJ
Am J Med Genet A. 2011
PubMed ID: 22043488
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The previously reported T342P GCK missense variant is not a pathogenic mutation causing MODY.
Steele AM, Tribble ND, Caswell R, Wensley KJ, Hattersley AT, Gloyn AL, Ellard S
Diabetologia. 2011
PubMed ID: 21604084
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Permanent diabetes during the first year of life: multiple gene screening in 54 patients.
Russo L, Iafusco D, Brescianini S, Nocerino V, Bizzarri C, Toni S, Cerutti F, Monciotti C, Pesavento R, Iughetti L, Bernardini L, Bonfanti R, Gargantini L, Vanelli M, Aguilar-Bryan L, Stazi MA, Grasso V, Colombo C, Barbetti F, ISPED Early Diabetes Study Group
Diabetologia. 2011
PubMed ID: 21544516
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Crystal structure of E339K mutated human glucokinase reveals changes in the ATP binding site.
Liu Q, Shen Y, Liu S, Weng J, Liu J
FEBS Lett. 2011
PubMed ID: 21420961
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Hypermethylation of hepatic glucokinase and L-type pyruvate kinase promoters in high-fat diet-induced obese rats.
Jiang M, Zhang Y, Liu M, Lan MS, Fei J, Fan W, Gao X, Lu D
Endocrinology. 2011
PubMed ID: 21239437
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A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
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Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C, Prokopenko I, Stolerman E, Sandhu MS, Heeney MM, Devaney JM, Reilly MP, Ricketts SL
Diabetes. 2010
PubMed ID: 20858683
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Chronically increased glucose uptake by adipose tissue leads to lactate production and improved insulin sensitivity rather than obesity in the mouse.
Muñoz S, Franckhauser S, Elias I, Ferré T, Hidalgo A, Monteys AM, Molas M, Cerdán S, Pujol A, Ruberte J, Bosch F
Diabetologia. 2010
PubMed ID: 20623219
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Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study.
Rasmussen-Torvik LJ, Li M, Kao W, Couper D, Boerwinkle E, Bielinski SJ, Folsom AR, Pankow JS
Diabetes. 2010
PubMed ID: 21036910
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Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer.
Naryzhny SN, Lee H
FEBS Lett. 2010
PubMed ID: 20849852
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Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase.
Larion M, Miller BG
Biochemistry. 2010
PubMed ID: 20828143
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Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.
de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, the MAGIC Investigators, the DIAGRAM Investigators, Meigs JB
Diabetes Care. 2010
PubMed ID: 20889853
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Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from the I
Freathy RM, Hayes MG, Urbanek M, Lowe LP, Lee H, Ackerman C, Frayling TM, Cox NJ, Dunger DB, Dyer AR, Hattersley AT, Metzger BE, Lowe WL, HAPO Study Cooperative Research Group
Diabetes. 2010
PubMed ID: 20682688
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Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
Diabetes. 2010
PubMed ID: 20682687
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
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Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer.
Dong X, Tang H, Hess KR, Abbruzzese JL, Li D
Cancer. 2010
PubMed ID: 20845477
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Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.
Hussain K
Rev Endocr Metab Disord. 2010
PubMed ID: 20878480
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Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.
Andersson EA, Pilgaard K, Pisinger C, Harder MN, Grarup N, Faerch K, Poulsen P, Witte DR, Jørgensen T, Vaag A, Hansen T, Pedersen O
Diabetologia. 2010
PubMed ID: 20490451
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[The functional analysis of glucokinase gene E339K mutation].
Shen YF, Liang H, Cai MY, Weng JP
Zhonghua Nei Ke Za Zhi. 2010
PubMed ID: 20979768
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Identification of two new mutations in the glucokinase gene that result in maturity-onset diabetes of the young.
Marks SD, Couch RM
Diabetes Care. 2010
PubMed ID: 20587714
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Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.
Babaya N, Fujisawa T, Nojima K, Itoi-Babaya M, Yamaji K, Yamada K, Kobayashi M, Ueda H, Hiromine Y, Noso S, Ikegami H
Diabetologia. 2010
PubMed ID: 20390404
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The glucokinase gene promoter polymorphism -30G>A (rs1799884) is associated with fasting glucose in healthy pregnant women but not with gestational diabetes.
Santos IC, Frigeri HR, Réa RR, Almeida AC, Souza EM, Pedrosa FO, Fadel-Picheth CM, Picheth G
Clin Chim Acta. 2010
PubMed ID: 20227404
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Heterozygous glucokinase mutations and birth weight in Spanish children.
de Las Heras J, Martínez R, Rica I, de Nanclares GP, Vela A, Castaño L, Spanish MODY group
Diabet Med. 2010
PubMed ID: 20536962
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Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.
Ingelsson E, Langenberg C, Hivert MF, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S, Jackson AU, Assimes TL, Shrader P, Knowles JW, Zethelius B, Abbasi FA, Bergman RN, Bergmann A, Berne C, Boehnke M, Bonnycastle LL, Bornstein SR, Buchanan TA, Bumpstead SJ, Böttcher Y, Chines P, Collins FS, Cooper CC, Dennison EM, Erdos MR, Ferrannini E, Fox CS, Graessler J, Hao K, Isomaa B, Jameson KA, Kovacs P, Kuusisto J, Laakso M, Ladenvall C, Mohlke KL, Morken MA, Narisu N, Nathan DM, Pascoe L, Payne F, Petrie JR, Sayer AA, Schwarz PE, Scott LJ, Stringham HM, Stumvoll M, Swift AJ, Syvänen AC, Tuomi T, Tuomilehto J, Tönjes A, Valle TT, Williams GH, Lind L, Barroso I, Quertermous T, Walker M, Wareham NJ, Meigs JB, McCarthy MI, Groop L, Watanabe RM, Florez JC, MAGIC investigators
Diabetes. 2010
PubMed ID: 20185807
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Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.
Flanagan SE, Kapoor RR, Mali G, Cody D, Murphy N, Schwahn B, Siahanidou T, Banerjee I, Akcay T, Rubio-Cabezas O, Shield JP, Hussain K, Ellard S
Eur J Endocrinol. 2010
PubMed ID: 20164212
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Three novel mutations in MODY and its phenotype in three different Czech families.
Bazalová Z, Rypácková B, Broz J, Brunerová L, Polák J, Rusavý Z, Treslová L, Andel M
Diabetes Res Clin Pract. 2010
PubMed ID: 20132997
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Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J
J Biol Chem. 2010
PubMed ID: 20185832
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Glucokinase diabetes in 103 families from a country-based study in the Czech Republic: geographically restricted distribution of two prevalent GCK mutations.
Pruhova S, Dusatkova P, Sumnik Z, Kolouskova S, Pedersen O, Hansen T, Cinek O, Lebl J
Pediatr Diabetes. 2010
PubMed ID: 20337973
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A novel glucokinase gene mutation and its effect on glycemic/C-peptide fluctuations in a patient with maturity-onset diabetes of the young type 2.
Loomba-Albrecht LA, Jame M, Bremer AA
Diabetes Res Clin Pract. 2010
PubMed ID: 20015564
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Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, Serizawa M, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Nabika T, Kasturiratne A, Yamaguchi S, Kono S, Takayanagi R, Yamori Y, Kobayashi S, Ogihara T, de Silva A, Wickremasinghe R, Kato N
Diabetologia. 2010
PubMed ID: 19937311
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Antidiabetic effects and gene expression profiling in obese mice treated with Isaria sinclairii over a 6-month period.
Ahn MY, Jee SD, Lee BM, Yeon JH, Park KK, Hwang JS, Yun EY
J Toxicol Environ Health A. 2010
PubMed ID: 20954077
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Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
Hu C, Zhang R, Wang C, Yu W, Lu J, Ma X, Wang J, Jiang F, Tang S, Bao Y, Xiang K, Jia W
PLoS One. 2010
PubMed ID: 20668700
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Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.
Leak TS, Langefeld CD, Keene KL, Gallagher CJ, Lu L, Mychaleckyj JC, Rich SS, Freedman BI, Bowden DW, Sale MM
BMC Med Genet. 2010
PubMed ID: 20144192
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Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
Circulation. 2009
PubMed ID: 19948975
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Glucokinase and glucokinase regulatory proteins are functionally coexpressed before birth in the rat brain.
Roncero I, Sanz C, Alvarez E, Vázquez P, Barrio PA, Blázquez E
J Neuroendocrinol. 2009
PubMed ID: 19807849
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Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
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Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.
Chambers JC, Zhang W, Zabaneh D, Sehmi J, Jain P, McCarthy MI, Froguel P, Ruokonen A, Balding D, Jarvelin MR, Scott J, Elliott P, Kooner JS
Diabetes. 2009
PubMed ID: 19651812
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Maturity-onset diabetes of the young in children with incidental hyperglycemia: a multicenter Italian study of 172 families.
Lorini R, Klersy C, d'Annunzio G, Massa O, Minuto N, Iafusco D, Bellannè-Chantelot C, Frongia AP, Toni S, Meschi F, Cerutti F, Barbetti F, Italian Society of Pediatric Endocrinology and Diabetology (ISPED) Study Group
Diabetes Care. 2009
PubMed ID: 19564454
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Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y
Int J Mol Med. 2009
PubMed ID: 19578796
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23-Residue C-terminal alpha-helix governs kinetic cooperativity in monomeric human glucokinase.
Larion M, Miller BG
Biochemistry. 2009
PubMed ID: 19473033
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Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.
Antoine M, Boutin JA, Ferry G
Biochemistry. 2009
PubMed ID: 19459610
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Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver.
Kim TH, Kim H, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH
J Biol Chem. 2009
PubMed ID: 19366697
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Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators.
Mitsuya M, Kamata K, Bamba M, Watanabe H, Sasaki Y, Sasaki K, Ohyama S, Hosaka H, Nagata Y, Eiki J, Nishimura T
Bioorg Med Chem Lett. 2009
PubMed ID: 19362831
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Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
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Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals.
Yamada Y, Ando F, Shimokata H
Hypertens Res. 2009
PubMed ID: 19282865
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Glucokinase Gene Mutation Screening in Argentinean Clinically Characterized MODY Patients.
Lopez AP, Foscaldi SA, Pérez MS, Krochik G, Rodríguez M, Traversa M, Puchulu FM, Hirschler V, Bergada I, Frechtel GD
Exp Clin Endocrinol Diabetes. 2009
PubMed ID: 19358091
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Biochemical characterization of MODY2 glucokinase variants V62M and G72R reveals reduced enzymatic activities relative to wild type.
Ralph EC, Sun S
Biochemistry. 2009
PubMed ID: 19187021
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Novel mutations in GCK and HNF1A genes in Italian families with MODY phenotype.
Cappelli A, Tumini S, Consoli A, Carinci S, Piersanti C, Ruggiero G, Simonella G, Soletti F, Staffolani P, Pianese L
Diabetes Res Clin Pract. 2009
PubMed ID: 19150152
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Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents.
Tam CH, Ma RC, So WY, Wang Y, Lam VK, Germer S, Martin M, Chan JC, Ng MC
Diabetes. 2009
PubMed ID: 19073768
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Activating mutations in the human glucokinase gene revealed by genetic selection.
Pal P, Miller BG
Biochemistry. 2009
PubMed ID: 19146401
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Lys169 of human glucokinase is a determinant for glucose phosphorylation: implication for the atomic mechanism of glucokinase catalysis.
Zhang J, Li C, Shi T, Chen K, Shen X, Jiang H
PLoS One. 2009
PubMed ID: 19617908
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Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients.
Khalil R, Al-Sheyab F, Khamaiseh E, Halaweh MA, Abder-Rahman HA
Genet Mol Res. 2009
PubMed ID: 19551638
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Pregnancy outcome in patients with raised blood glucose due to a heterozygous glucokinase gene mutation.
Spyer G, Macleod KM, Shepherd M, Ellard S, Hattersley AT
Diabet Med. 2009
PubMed ID: 19125755
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The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.
Webster RJ, Warrington NM, Weedon MN, Hattersley AT, McCaskie PA, Beilby JP, Palmer LJ, Frayling TM
Diabetologia. 2009
PubMed ID: 19018513
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Prevalence of GCK mutations in individuals screened for fasting hyperglycaemia.
Gloyn AL, van de Bunt M, Stratton IM, Lonie L, Tucker L, Ellard S, Holman RR
Diabetologia. 2009
PubMed ID: 19002431
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Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
Paré G, Chasman DI, Parker AN, Nathan DM, Miletich JP, Zee RY, Ridker PM
PLoS Genet. 2008
PubMed ID: 19096518
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A combination of HNF-4 and Foxo1 is required for reciprocal transcriptional regulation of glucokinase and glucose-6-phosphatase genes in response to fasting and feeding.
Hirota K, Sakamaki J, Ishida J, Shimamoto Y, Nishihara S, Kodama N, Ohta K, Yamamoto M, Tanimoto K, Fukamizu A
J Biol Chem. 2008
PubMed ID: 18805788
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Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses.
Souren NY, Zeegers MP, Janssen RG, Steyls A, Gielen M, Loos RJ, Beunen G, Fagard R, Stassen AP, Aerssens J, Derom C, Vlietinck R, Paulussen AD
Twin Res Hum Genet. 2008
PubMed ID: 18828733
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Activation and translocation of glucokinase in rat primary hepatocytes monitored by high content image analysis.
Wolff M, Kauschke SG, Schmidt S, Heilker R
J Biomol Screen. 2008
PubMed ID: 18812575
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The islet beta-cell: fuel responsive and vulnerable.
Nolan CJ, Prentki M
Trends Endocrinol Metab. 2008
PubMed ID: 18774732
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Mutations of maturity-onset diabetes of the young (MODY) genes in Thais with early-onset type 2 diabetes mellitus.
Plengvidhya N, Boonyasrisawat W, Chongjaroen N, Jungtrakoon P, Sriussadaporn S, Vannaseang S, Banchuin N, Yenchitsomanus PT
Clin Endocrinol (Oxf). 2008
PubMed ID: 18811724
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Low prevalence of MODY2 and MODY3 mutations in Brazilian individuals with clinical MODY phenotype.
Furuzawa GK, Giuffrida FM, Oliveira CS, Chacra AR, Dib SA, Reis AF
Diabetes Res Clin Pract. 2008
PubMed ID: 18672310
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Glucokinase and molecular aspects of liver glycogen metabolism.
Agius L
Biochem J. 2008
PubMed ID: 18651836
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The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general french population.
Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P, DESIR Study Group
Diabetes. 2008
PubMed ID: 18556336
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Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential.
Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu DR
Diabetologia. 2008
PubMed ID: 18496667
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Sugar binding to recombinant wild-type and mutant glucokinase monitored by kinetic measurement and tryptophan fluorescence.
Zelent B, Odili S, Buettger C, Shiota C, Grimsby J, Taub R, Magnuson MA, Vanderkooi JM, Matschinsky FM
Biochem J. 2008
PubMed ID: 18370929
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Long-term follow-up of oral glucose tolerance test-derived glucose tolerance and insulin secretion and insulin sensitivity indexes in subjects with glucokinase mutations (MODY2).
Martin D, Bellanné-Chantelot C, Deschamps I, Froguel P, Robert JJ, Velho G
Diabetes Care. 2008
PubMed ID: 18411240
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Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.
Holmkvist J, Almgren P, Lyssenko V, Lindgren CM, Eriksson KF, Isomaa B, Tuomi T, Nilsson P, Groop L
Diabetes. 2008
PubMed ID: 18332101
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Gene duplications resulting in over expression of glucokinase are not a common cause of hypoglycaemia of infancy in humans.
van de Bunt M, Edghill EL, Hussain K, Ellard S, Gloyn AL
Mol Genet Metab. 2008
PubMed ID: 18325809
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Haploinsufficiency at GCK gene is not a frequent event in MODY2 patients.
Garin I, Rica I, Estalella I, Oyarzabal M, Rodríguez-Rigual M, San Pedro JI, Pérez-Nanclares G, Fernández-Rebollo E, Busturia MA, Castaño L, Pérez de Nanclares G, Spanish MODY Group
Clin Endocrinol (Oxf). 2008
PubMed ID: 18248649
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The -30G>A Polymorphism of the Glucokinase Gene Promoter Is Associated With Obesity in a Population From Southern Spain.
Gómez-Zumaquero JM, Rojo-Martínez G, García-Escobar E, Martín-Nuñez GM, Haro J, Esteva I, Ruiz de Adana M, Cuesta AL, Olveira G, Morcillo S, Soriguer F
Obesity (Silver Spring). 2008
PubMed ID: 18483479
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Activating glucokinase (GCK) mutations as a cause of medically responsive congenital hyperinsulinism: prevalence in children and characterization of a novel GCK mutation.
Christesen H, Tribble N, Molven A, Siddiqui J, Sandal T, Brusgaard K, Ellard S, Njoelstad P, Alm J, Jacobsen B, Hussain K, Gloyn A
Eur J Endocrinol. 2008
PubMed ID: 18450771
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Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions.
Molnes J, Bjørkhaug L, Søvik O, Njølstad PR, Flatmark T
FEBS J. 2008
PubMed ID: 18397317
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Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.
Levin BE, Becker TC, Eiki J, Zhang BB, Dunn-Meynell AA
Diabetes. 2008
PubMed ID: 18292346
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Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks.
Christesen HB, Brusgaard K, Beck Nielsen H, Brock Jacobsen B
Clin Endocrinol (Oxf). 2008
PubMed ID: 18208578
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An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.
Baggio LL, Huang Q, Cao X, Drucker DJ
Gastroenterology. 2008
PubMed ID: 18313669
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Mutations in the glucokinase gene of the fetus result in reduced placental weight.
Shields BM, Spyer G, Slingerland AS, Knight BA, Ellard S, Clark PM, Hauguel-de Mouzon S, Hattersley AT
Diabetes Care. 2008
PubMed ID: 18184897
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Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Mukhtar MH, Payne VA, Arden C, Harbottle A, Khan S, Lange AJ, Agius L
Am J Physiol Regul Integr Comp Physiol. 2008
PubMed ID: 18199594
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Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver.
Cifuentes D, Martínez-Pons C, García-Rocha M, Galina A, de Pouplana LR, Guinovart JJ
J Biol Chem. 2008
PubMed ID: 18165236
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Screening of mutations and polymorphisms in the glucokinase gene in Czech diabetic and healthy control populations.
Lukášová P, Včelák J, Vaňková M, Vejražková D, Andělová K, Bendlová B
Physiol Res. 2008
PubMed ID: 18271687
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Effects of caudal fourth ventricular lactate infusion on hypoglycemia-associated MCT2, GLUT3, GLUT4, GCK, and sulfonylurea receptor-1 gene expression in the ovariectomized female rat LHA and VMH: impact of estradiol.
Vavaiya KV, Briski KP
J Mol Neurosci. 2008
PubMed ID: 18084728
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Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.
Aigner B, Rathkolb B, Herbach N, Hrabé de Angelis M, Wanke R, Wolf E
Am J Physiol Endocrinol Metab. 2008
PubMed ID: 18056790
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G/A Polymorphism at -258 of the Hepatic Glucokinase Promoter Is Not Associated with Decreased Birth Weight in Preterm Neonates.
Pawlowski M, Kouklinos A, Jopp-Petzina G, Herkenrath P, Fischer M, Kribs A, Roth B, Roth J, Tenbrock K
Neonatology. 2008
PubMed ID: 18196929
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The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
Cauchi S, Nead KT, Choquet H, Horber F, Potoczna N, Balkau B, Marre M, Charpentier G, Froguel P, Meyre D
BMC Med Genet. 2008
PubMed ID: 18498634
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Glucokinase gene mutations: structural and genotype-phenotype analyses in MODY children from South Italy.
Tinto N, Zagari A, Capuano M, De Simone A, Capobianco V, Daniele G, Giugliano M, Spadaro R, Franzese A, Sacchetti L
PLoS ONE. 2008
PubMed ID: 18382660
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Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.
Estalella I, Garcia-Gimeno MA, Marina A, Castaño L, Sanz P
J Hum Genet. 2008
PubMed ID: 18322640
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Caudal hindbrain lactate infusion alters glucokinase, SUR1, and neuronal substrate fuel transporter gene expression in the dorsal vagal complex, lateral hypothalamic area, and ventromedial nucleus hypothalamus of hypoglycemic male rats.
Vavaiya KV, Briski KP
Brain Res. 2007
PubMed ID: 17889836
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Mutations in GCK and HNF-1alpha explain the majority of cases with clinical diagnosis of MODY in Spain.
Estalella I, Rica I, Perez de Nanclares G, Bilbao JR, Vazquez JA, San Pedro JI, Busturia MA, Castaño L, Spanish MODY Group
Clin Endocrinol (Oxf). 2007
PubMed ID: 17573900
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Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release.
Zhong J, Kyriakis JM
J Biol Chem. 2007
PubMed ID: 17584736
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Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.
Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A
EMBO J. 2007
PubMed ID: 17627282
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Four novel mutations, including the first gross deletion in TCF1, identified in HNF-4alpha, GCK and TCF1 in patients with MODY in Israel.
Stern E, Strihan C, Potievsky O, Nimri R, Shalitin S, Cohen O, Shehadeh N, Weintrob N, Phillip M, Gat-Yablonski G
J Pediatr Endocrinol Metab. 2007
PubMed ID: 17937063
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Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats.
Payne VA, Arden C, Lange AJ, Agius L
Am J Physiol Regul Integr Comp Physiol. 2007
PubMed ID: 17553851
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Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.
Fyfe MC, White JR, Taylor A, Chatfield R, Wargent E, Printz RL, Sulpice T, McCormack JG, Procter MJ, Reynet C, Widdowson PS, Wong-Kai-In P
Diabetologia. 2007
PubMed ID: 17415548
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Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.
Johnson D, Shepherd RM, Gill D, Gorman T, Smith DM, Dunne MJ
Diabetes. 2007
PubMed ID: 17360975
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Effects of glucose and insulin on glucokinase activity in rat hypothalamus.
Sanz C, Roncero I, Vázquez P, Navas MA, Blázquez E
J Endocrinol. 2007
PubMed ID: 17470517
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Compromised beta-cell development and beta-cell dysfunction in weanling offspring from dams maintained on a high-fat diet during gestation.
Cerf ME, Williams K, Chapman CS, Louw J
Pancreas. 2007
PubMed ID: 17414058
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Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Okamoto Y, Ogawa W, Nishizawa A, Inoue H, Teshigawara K, Kinoshita S, Matsuki Y, Watanabe E, Hiramatsu R, Sakaue H, Noda T, Kasuga M
Diabetes. 2007
PubMed ID: 17267763
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Glucokinase regulates reproductive function, glucocorticoid secretion, food intake, and hypothalamic gene expression.
Yang XJ, Mastaitis J, Mizuno T, Mobbs CV
Endocrinology. 2007
PubMed ID: 17218412
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A defect in glucose-induced dissociation of glucokinase from the regulatory protein in Zucker diabetic fatty rats in the early stage of diabetes.
Shin JS, Torres TP, Catlin RL, Donahue EP, Shiota M
Am J Physiol Regul Integr Comp Physiol. 2007
PubMed ID: 17204595
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GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes.
Zurawek M, Wender-Ozegowska E, Januszkiewicz-Lewandowska D, Zawiejska A, Nowak J
Diabetes Res Clin Pract. 2007
PubMed ID: 16963153
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Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes.
Winckler W, Weedon MN, Graham RR, McCarroll SA, Purcell S, Almgren P, Tuomi T, Gaudet D, Boström KB, Walker M, Hitman G, Hattersley AT, McCarthy MI, Ardlie KG, Hirschhorn JN, Daly MJ, Frayling TM, Groop L, Altshuler D
Diabetes. 2007
PubMed ID: 17327436
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A pre-steady state analysis of ligand binding to human glucokinase: evidence for a preexisting equilibrium.
Kim YB, Kalinowski SS, Marcinkeviciene J
Biochemistry. 2007
PubMed ID: 17260972
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Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17215356
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[Glucokinase gene mutations in gestational diabetes in Polish population. Prediction of diabetes mellitus development after delivery]
Okruszko A, Kinalski M, Kuźmicki M, Mirończuk K, Wawrusiewicz-Kurylonek N, Kinalska I, Kretowski A
Przegl Lek. 2007
PubMed ID: 18159847
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An analysis of expression patterns of genes encoding proteins with catalytic activities.
Cankaya M, Hernandez AM, Ciftci M, Beydemir S, Ozdemir H, Budak H, Gulcin I, Comakli V, Emircupani T, Ekinci D, Kuzu M, Jiang Q, Eichele G, Kufrevioglu OI
BMC Genomics. 2007
PubMed ID: 17626619
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Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.
Heredia VV, Carlson TJ, Garcia E, Sun S
J Biol Chem. 2006
PubMed ID: 17082186
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A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.
Weedon MN, Clark VJ, Qian Y, Ben-Shlomo Y, Timpson N, Ebrahim S, Lawlor DA, Pembrey ME, Ring S, Wilkin TJ, Voss LD, Jeffery AN, Metcalf B, Ferrucci L, Corsi AM, Murray A, Melzer D, Knight B, Shields B, Smith GD, Hattersley AT, Di Rienzo A, Frayling TM
Am J Hum Genet. 2006
PubMed ID: 17186458
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Assessment of the genetic component of hypertension.
Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, Yokoi K, Ichihara S, Metoki N, Yoshida H, Satoh K, Nozawa Y
Am J Hypertens. 2006
PubMed ID: 17070428
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Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.
Hansmannel F, Mordier S, Iynedjian PB
Biochem J. 2006
PubMed ID: 16834571
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Genetic and clinical characteristics of Korean maturity-onset diabetes of the young (MODY) patients.
Hwang JS, Shin CH, Yang SW, Jung SY, Huh N
Diabetes Res Clin Pract. 2006
PubMed ID: 16632067
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Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.
Bonnycastle LL, Willer CJ, Conneely KN, Jackson AU, Burrill CP, Watanabe RM, Chines PS, Narisu N, Scott LJ, Enloe ST, Swift AJ, Duren WL, Stringham HM, Erdos MR, Riebow NL, Buchanan TA, Valle TT, Tuomilehto J, Bergman RN, Mohlke KL, Boehnke M, Collins FS
Diabetes. 2006
PubMed ID: 16936201
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A glucose sensor role for glucokinase in anterior pituitary cells.
Zelent D, Golson ML, Koeberlein B, Quintens R, van Lommel L, Buettger C, Weik-Collins H, Taub R, Grimsby J, Schuit F, Kaestner KH, Matschinsky FM
Diabetes. 2006
PubMed ID: 16804059
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Glucokinase regulatory protein is associated with mitochondria in hepatocytes.
Arden C, Baltrusch S, Agius L
FEBS Lett. 2006
PubMed ID: 16542652
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BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
PLoS Biol. 2006
PubMed ID: 16602821
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In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping.
Briançon N, Weiss MC
EMBO J. 2006
PubMed ID: 16498401
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Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.
Kang L, Dunn-Meynell AA, Routh VH, Gaspers LD, Nagata Y, Nishimura T, Eiki J, Zhang BB, Levin BE
Diabetes. 2006
PubMed ID: 16443775
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Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S
Genome Res. 2006
PubMed ID: 16344560
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[Contribution of MODY2 gene to the pathogenesis of Chinese early onset familial type 2 diabetes]
Han XY, Ji LN
Beijing Da Xue Xue Bao. 2005
PubMed ID: 16378108
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[Mutation screening of GCK gene in Chinese early-onset diabetes population]
Zheng TS, Wu SH, Yang Z, Lu HJ, Xiang KS
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005
PubMed ID: 16331569
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Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme.
Baltrusch S, Francini F, Lenzen S, Tiedge M
Diabetes. 2005
PubMed ID: 16186382
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Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
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The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
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Structure-function analysis of the alpha5 and the alpha13 helices of human glucokinase: description of two novel activating mutations.
Pedelini L, Garcia-Gimeno MA, Marina A, Gomez-Zumaquero JM, Rodriguez-Bada P, López-Enriquez S, Soriguer FC, Cuesta-Muñoz AL, Sanz P
Protein Sci. 2005
PubMed ID: 15987895
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Identification of novel polymorphisms in the glucokinase and glucose-6-phosphatase genes in infants who died suddenly and unexpectedly.
Forsyth L, Hume R, Howatson A, Busuttil A, Burchell A
J Mol Med. 2005
PubMed ID: 15918042
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Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.
Payne VA, Arden C, Wu C, Lange AJ, Agius L
Diabetes. 2005
PubMed ID: 15983194
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Mapping and exclusion mapping of genomic imprinting effects in mouse F2 families.
Mantey C, Brockmann GA, Kalm E, Reinsch N
J Hered. 2005
PubMed ID: 15761081
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Tacrolimus suppresses glucose-induced insulin release from pancreatic islets by reducing glucokinase activity.
Radu RG, Fujimoto S, Mukai E, Takehiro M, Shimono D, Nabe K, Shimodahira M, Kominato R, Aramaki Y, Nishi Y, Funakoshi S, Yamada Y, Seino Y
Am J Physiol Endocrinol Metab. 2005
PubMed ID: 15479952
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Gene and alternative splicing annotation with AIR.
Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G
Genome Res. 2005
PubMed ID: 15632090
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Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.
Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M
Nature. 2004
PubMed ID: 15616563
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Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs.
Zhang YL, Tan XH, Xiao MF, Li H, Mao YQ, Yang X, Tan HR
Acta Pharmacol Sin. 2004
PubMed ID: 15569412
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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
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Defect in glucokinase translocation in Zucker diabetic fatty rats.
Fujimoto Y, Donahue EP, Shiota M
Am J Physiol Endocrinol Metab. 2004
PubMed ID: 15138155
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SREBP-1c mediates the insulin-dependent hepatic glucokinase expression.
Kim SY, Kim HI, Kim TH, Im SS, Park SK, Lee IK, Kim KS, Ahn YH
J Biol Chem. 2004
PubMed ID: 15123649
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Spectrum of HNF1A and GCK mutations in Canadian families with maturity-onset diabetes of the young (MODY).
McKinney JL, Cao H, Robinson JF, Metzger DL, Cummings E, Riddell DC, Sanderson SR, Pacaud D, Ho J, Hegele RA
Clin Invest Med. 2004
PubMed ID: 15305805
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A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.
Toye AA, Moir L, Hugill A, Bentley L, Quarterman J, Mijat V, Hough T, Goldsworthy M, Haynes A, Hunter AJ, Browne M, Spurr N, Cox RD
Diabetes. 2004
PubMed ID: 15161764
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Hepatic glucokinase is required for the synergistic action of ChREBP and SREBP-1c on glycolytic and lipogenic gene expression.
Dentin R, Pégorier JP, Benhamed F, Foufelle F, Ferré P, Fauveau V, Magnuson MA, Girard J, Postic C
J Biol Chem. 2004
PubMed ID: 14985368
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Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
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ATP-citrate lyase deficiency in the mouse.
Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG
J Biol Chem. 2004
PubMed ID: 14662765
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Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase.
Kamata K, Mitsuya M, Nishimura T, Eiki J, Nagata Y
Structure. 2004
PubMed ID: 15016359
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Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain.
Roncero I, Alvarez E, Chowen JA, Sanz C, Rábano A, Vázquez P, Blázquez E
J Neurochem. 2004
PubMed ID: 15009676
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Differences in regulatory properties between human and rat glucokinase regulatory protein.
Brocklehurst KJ, Davies RA, Agius L
Biochem J. 2004
PubMed ID: 14627435
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Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma.
Kim SY, Kim HI, Park SK, Im SS, Li T, Cheon HG, Ahn YH
Diabetes. 2004
PubMed ID: 14749268
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Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice.
Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Granner DK, Wasserman DH
Diabetes. 2004
PubMed ID: 14747279
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A potential role for fructose-2,6-bisphosphate in the stimulation of hepatic glucokinase gene expression.
Wu C, Okar DA, Stoeckman AK, Peng LJ, Herrera AH, Herrera JE, Towle HC, Lange AJ
Endocrinology. 2004
PubMed ID: 14617577
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Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming.
Bogdarina I, Murphy HC, Burns SP, Clark AJ
Life Sci. 2004
PubMed ID: 14706571
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
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GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Visel A, Thaller C, Eichele G
Nucleic Acids Res. 2004
PubMed ID: 14681479
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Analysis of the role of protein kinase B (cAKT) in insulin-dependent induction of glucokinase and sterol regulatory element-binding protein 1 (SREBP1) mRNAs in hepatocytes.
Ribaux PG, Iynedjian PB
Biochem J. 2003
PubMed ID: 14505487
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A modest glucokinase overexpression in the liver promotes fed expression levels of glycolytic and lipogenic enzyme genes in the fasted state without altering SREBP-1c expression.
Scott DK, Collier JJ, Doan TT, Bunnell AS, Daniels MC, Eckert DT, O'Doherty RM
Mol Cell Biochem. 2003
PubMed ID: 14674713
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Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M
Cell. 2003
PubMed ID: 14651853
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Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
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Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway.
Njølstad PR, Sagen JV, Bjørkhaug L, Odili S, Shehadeh N, Bakry D, Sarici SU, Alpay F, Molnes J, Molven A, Søvik O, Matschinsky FM
Diabetes. 2003
PubMed ID: 14578306
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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ
Nature. 2003
PubMed ID: 12931191
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The DNA sequence of human chromosome 7.
Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK
Nature. 2003
PubMed ID: 12853948
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Human chromosome 7: DNA sequence and biology.
Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Döhner H, Döhner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC
Science. 2003
PubMed ID: 12690205
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Kinetic studies of rat liver hexokinase D ('glucokinase') in non-co-operative conditions show an ordered mechanism with MgADP as the last product to be released.
Monasterio O, Cárdenas ML
Biochem J. 2003
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Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.
Gomis RR, Favre C, García-Rocha M, Fernández-Novell JM, Ferrer JC, Guinovart JJ
J Biol Chem. 2003
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Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha.
Pruhova S, Ek J, Lebl J, Sumnik Z, Saudek F, Andel M, Pedersen O, Hansen T
Diabetologia. 2003
PubMed ID: 12627330
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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
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Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
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GCK and HNF1A mutations in Canadian families with maturity onset diabetes of the young (MODY).
Cao H, Shorey S, Robinson J, Metzger DL, Stewart L, Cummings E, Hegele RA
Hum Mutat. 2002
PubMed ID: 12442280
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Novel phenotypes identified by plasma biochemical screening in the mouse.
Hough TA, Nolan PM, Tsipouri V, Toye AA, Gray IC, Goldsworthy M, Moir L, Cox RD, Clements S, Glenister PH, Wood J, Selley RL, Strivens MA, Vizor L, McCormack SL, Peters J, Fisher EM, Spurr N, Rastan S, Martin JE, Brown SD, Hunter AJ
Mamm Genome. 2002
PubMed ID: 12420138
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DNA microarray analysis of cannabinoid signaling in mouse brain in vivo.
Parmentier-Batteur S, Jin K, Xie L, Mao XO, Greenberg DA
Mol Pharmacol. 2002
PubMed ID: 12237329
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Polymorphisms in genes involved in glucose metabolism in cases of sudden infant death syndrome.
Burchell A, Forsyth L, Hume R
Child Care Health Dev. 2002
PubMed ID: 12515438
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Improved metabolic disorders of insulin receptor-deficient mice by transgenic overexpression of glucokinase in the liver.
Jackerott M, Baudry A, Bucchini D, Jami J, Joshi RL
Diabetologia. 2002
PubMed ID: 12242462
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Glucokinase is the likely mediator of glucosensing in both glucose-excited and glucose-inhibited central neurons.
Dunn-Meynell AA, Routh VH, Kang L, Gaspers L, Levin BE
Diabetes. 2002
PubMed ID: 12086933
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Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.
Roth U, Jungermann K, Kietzmann T
Biochem J. 2002
PubMed ID: 11950391
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Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families.
Barrio R, Bellanné-Chantelot C, Moreno JC, Morel V, Calle H, Alonso M, Mustieles C
J Clin Endocrinol Metab. 2002
PubMed ID: 12050210
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Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.
Matsumoto M, Ogawa W, Teshigawara K, Inoue H, Miyake K, Sakaue H, Kasuga M
Diabetes. 2002
PubMed ID: 12031952
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Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase.
Veiga-da-Cunha M, Van Schaftingen E
J Biol Chem. 2002
PubMed ID: 11756407
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Glucokinase gene mutations are not a common cause of permanent neonatal diabetes in France.
Vaxillaire M, Samson C, Cavé H, Metz C, Froguel P, Polak M
Diabetologia. 2002
PubMed ID: 11914755
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Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.
Slosberg ED, Desai UJ, Fanelli B, St Denny I, Connelly S, Kaleko M, Boettcher BR, Caplan SL
Diabetes. 2001
PubMed ID: 11473043
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Routine mutation screening of HNF-1alpha and GCK genes in MODY diagnosis: how effective are the techniques of DHPLC and direct sequencing used in combination?
Boutin P, Vasseur F, Samson C, Wahl C, Froguel P
Diabetologia. 2001
PubMed ID: 11440371
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Neonatal diabetes mellitus due to complete glucokinase deficiency.
Njølstad PR, Søvik O, Cuesta-Muñoz A, Bjørkhaug L, Massa O, Barbetti F, Undlien DE, Shiota C, Magnuson MA, Molven A, Matschinsky FM, Bell GI
N Engl J Med. 2001
PubMed ID: 11372010
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Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.
Shiota M, Postic C, Fujimoto Y, Jetton TL, Dixon K, Pan D, Grimsby J, Grippo JF, Magnuson MA, Cherrington AD
Diabetes. 2001
PubMed ID: 11246883
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Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
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Substrate-induced nuclear export and peripheral compartmentalization of hepatic glucokinase correlates with glycogen deposition.
Jetton TL, Shiota M, Knobel SM, Piston DW, Cherrington AD, Magnuson MA
Int J Exp Diabetes Res. 2001
PubMed ID: 12369705
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Identification of glucokinase mutation in subjects with post-renal transplantation diabetes mellitus.
Nam JH, Lee HC, Kim YH, Cha BS, Song YD, Lim SK, Kim KR, Huh KB
Diabetes Res Clin Pract. 2000
PubMed ID: 11106831
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RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
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Activation of protein kinase B/cAkt in hepatocytes is sufficient for the induction of expression of the gene encoding glucokinase.
Iynedjian PB, Roth RA, Fleischmann M, Gjinovci A
Biochem J. 2000
PubMed ID: 11042116
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A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate.
Muñoz-Alonso MJ, Guillemain G, Kassis N, Girard J, Burnol AF, Leturque A
J Biol Chem. 2000
PubMed ID: 10913113
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Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
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Gaping lids, gp, a mutation on centromeric chromosome 11 that causes defective eyelid development in mice.
Juriloff DM, Harris MJ, Banks KG, Mah DG
Mamm Genome. 2000
PubMed ID: 10818208
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Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.
Shiota C, Coffey J, Grimsby J, Grippo JF, Magnuson MA
J Biol Chem. 1999
PubMed ID: 10601273
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Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.
O'Doherty RM, Lehman DL, Télémaque-Potts S, Newgard CB
Diabetes. 1999
PubMed ID: 10512368
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Glucokinase is concentrated in insulin-secretory granules of pancreatic B-cells.
Toyoda Y, Yoshie S, Shironoguchi H, Miwa I
Histochem Cell Biol. 1999
PubMed ID: 10461810
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High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
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Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex.
Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE
Nat Genet. 1998
PubMed ID: 9662407
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Mutations in the glucokinase gene of the fetus result in reduced birth weight.
Hattersley AT, Beards F, Ballantyne E, Appleton M, Harvey R, Ellard S
Nat Genet. 1998
PubMed ID: 9662401
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Evolution and regulatory role of the hexokinases.
Cárdenas ML, Cornish-Bowden A, Ureta T
Biochim Biophys Acta. 1998
PubMed ID: 9540816
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Familial hyperinsulinism caused by an activating glucokinase mutation.
Glaser B, Kesavan P, Heyman M, Davis E, Cuesta A, Buchs A, Stanley CA, Thornton PS, Permutt MA, Matschinsky FM, Herold KC
N Engl J Med. 1998
PubMed ID: 9435328
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Familial hyperinsulinism with apparent autosomal dominant inheritance: clinical and genetic differences from the autosomal recessive variant.
Thornton PS, Satin-Smith MS, Herold K, Glaser B, Chiu KC, Nestorowicz A, Permutt MA, Baker L, Stanley CA
J Pediatr. 1998
PubMed ID: 9469993
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Three novel missense mutations in the glucokinase gene (G80S; E221K; G227C) in Italian subjects with maturity-onset diabetes of the young (MODY). Mutations in brief no. 162. Online.
Guazzini B, Gaffi D, Mainieri D, Multari G, Cordera R, Bertolini S, Pozza G, Meschi F, Barbetti F
Hum Mutat. 1998
PubMed ID: 10694920
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Variable expression of hepatic glucokinase in mice is due to a regulational locus that cosegregates with the glucokinase gene.
Moates JM, Postic C, Decaux JF, Girard J, Magnuson MA
Genomics. 1997
PubMed ID: 9339375
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Nucleotide(-258) G-to-A transition variant of the liver glucokinase gene is associated with essential hypertension.
Chiang FT, Chiu KC, Tseng YZ, Lee KC, Chuang LM
Am J Hypertens. 1997
PubMed ID: 9324112
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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.
Velho G, Blanché H, Vaxillaire M, Bellanné-Chantelot C, Pardini VC, Timsit J, Passa P, Deschamps I, Robert JJ, Weber IT, Marotta D, Pilkis SJ, Lipkind GM, Bell GI, Froguel P
Diabetologia. 1997
PubMed ID: 9049484
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Amino acid conservation in animal glucokinases. Identification of residues implicated in the interaction with the regulatory protein.
Veiga-da-Cunha M, Courtois S, Michel A, Gosselain E, Van Schaftingen E
J Biol Chem. 1996
PubMed ID: 8626423
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Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene.
Altomare DA, Kozak CA, Sonoda G, Testa JR
Cytogenet Cell Genet. 1996
PubMed ID: 8976376
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Mor2, supernatant malate dehydrogenase, is linked to wa2 and Hba on mouse chromosome 11 in a region of homology with human chromosome 2p.
Ball ST, Moseley HJ, Peters J
Genomics. 1994
PubMed ID: 7698769
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Six mutations in the glucokinase gene identified in MODY by using a nonradioactive sensitive screening technique.
Hager J, Blanché H, Sun F, Vaxillaire NV, Poller W, Cohen D, Czernichow P, Velho G, Robert JJ, Cohen N
Diabetes. 1994
PubMed ID: 8168652
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Mutations in the glucokinase gene are not a major cause of late-onset type 2 (non-insulin-dependent) diabetes mellitus in Japanese subjects.
Nishi S, Hinata S, Matsukage T, Takeda J, Ichiyama A, Bell GI, Yoshimi T
Diabet Med. 1994
PubMed ID: 8200206
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Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
Byrne MM, Sturis J, Clément K, Vionnet N, Pueyo ME, Stoffel M, Takeda J, Passa P, Cohen D, Bell GI
J Clin Invest. 1994
PubMed ID: 8132752
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Deletion of the donor splice site of intron 4 in the glucokinase gene causes maturity-onset diabetes of the young.
Sun F, Knebelmann B, Pueyo ME, Zouali H, Lesage S, Vaxillaire M, Passa P, Cohen D, Velho G, Antignac C
J Clin Invest. 1993
PubMed ID: 8376578
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Polymorphic microsatellite repeat markers at the glucokinase gene locus are positively associated with NIDDM in Japanese.
Noda K, Matsutani A, Tanizawa Y, Neuman R, Kaneko T, Permutt MA, Kaku K
Diabetes. 1993
PubMed ID: 8325445
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Identification of glucokinase mutations in subjects with gestational diabetes mellitus.
Stoffel M, Bell KL, Blackburn CL, Powell KL, Seo TS, Takeda J, Vionnet N, Xiang KS, Gidh-Jain M, Pilkis SJ
Diabetes. 1993
PubMed ID: 8495817
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Non-sense mutation of glucokinase gene.
Chiu KC, Tanizawa Y, Permutt MA
Lancet. 1993
PubMed ID: 8094164
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Non-sense mutation of glucokinase gene.
Froguel P, Velho G
Lancet. 1993
PubMed ID: 8094163
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Structure of the human glucokinase gene and identification of a missense mutation in a Japanese patient with early-onset non-insulin-dependent diabetes mellitus.
Sakura H, Eto K, Kadowaki H, Simokawa K, Ueno H, Koda N, Fukushima Y, Akanuma Y, Yazaki Y, Kadowaki T
J Clin Endocrinol Metab. 1992
PubMed ID: 1464666
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Missense glucokinase mutation in maturity-onset diabetes of the young and mutation screening in late-onset diabetes.
Stoffel M, Patel P, Lo YM, Hattersley AT, Lucassen AM, Page R, Bell JI, Bell GI, Turner RC, Wainscoat JS
Nat Genet. 1992
PubMed ID: 1303265
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Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus.
Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GI, Zouali H, Lesage S, Velho G, Iris F, Passa P
Nature. 1992
PubMed ID: 1570017
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Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus.
Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, Lesage S, Vionnet N, Clément K, Fougerousse F
Nature. 1992
PubMed ID: 1545870
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A 2-cM genetic linkage map of human chromosome 7p that includes 47 loci.
Mishra SK, Helms C, Dorsey D, Permutt MA, Donis-Keller H
Genomics. 1992
PubMed ID: 1740342
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A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p.
Matsutani A, Janssen R, Donis-Keller H, Permutt MA
Genomics. 1992
PubMed ID: 1740341
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Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs.
Tanizawa Y, Koranyi LI, Welling CM, Permutt MA
Proc Natl Acad Sci U S A. 1991
PubMed ID: 1871135
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Alternative splicing of glucokinase mRNA in rat liver.
Hayzer DJ, Iynedjian PB
Biochem J. 1990
PubMed ID: 2396986
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Kinetic behaviour of liver glucokinase in diabetes. I. Alteration in streptozotocin-diabetic rats.
Zähner D, Malaisse WJ
Diabetes Res. 1990
PubMed ID: 2132180
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Characterization of the 5' flanking region of rat glucokinase gene.
Noguchi T, Takenaka M, Yamada K, Matsuda T, Hashimoto M, Tanaka T
Biochem Biophys Res Commun. 1989
PubMed ID: 2590200
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Rat glucokinase gene: structure and regulation by insulin.
Magnuson MA, Andreone TL, Printz RL, Koch S, Granner DK
Proc Natl Acad Sci U S A. 1989
PubMed ID: 2662183
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The amino acid sequence of rat liver glucokinase deduced from cloned cDNA.
Andreone TL, Printz RL, Pilkis SJ, Magnuson MA, Granner DK
J Biol Chem. 1989
PubMed ID: 2909525
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Comparison of glucokinase in C3H/He and C58 mice that differ in their hepatic activity.
James PA, Lavender FL, Lawrence GM, Walker DG
Biochem Genet. 1985
PubMed ID: 3931624
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Hepatic glucokinase activity and circulating insulin concentrations in two inbred mouse strains.
Lavender FL, James PA, Walker DG
Diabetologia. 1983
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Genetic control of glucokinase activity in mice.
Coleman DL
Biochem Genet. 1977
PubMed ID: 141272
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Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo.
Gunn JM, Taylor CB
Biochem J. 1973
PubMed ID: 4273555
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Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate.
Wimhurst JM, Manchester KL
Biochem J. 1973
PubMed ID: 4353083
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