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GCG

Gene Description:   glucagon Synonyms:   GCG, GLP-1, GRPP, GLP2, GLP1, Gcg Orthologs:   Human GCG (protein-coding), Mouse Gcg (protein-coding), Rat Gcg (protein-coding)   Sources Sources Human-Mouse: HomoloGene, MGD, RGD, KEGG Human-Rat: HomoloGene, MGD, RGD, KEGG Mouse-Rat: HomoloGene, MGD, RGD, Inparanoid, OrthoMCL, KEGG Possible sources: HomoloGene, MGD, RGD, Ensembl, Inparanoid, OrthoMCL, KEGG

Regions Overlapping this Feature:  Human: 1 Mouse: 1 Rat: 1

Associated Regions: Available

Regions were calculated based on variants available for a large study with a convincing p-value (P < 5 x 10^-8) +/- 0.1cM, and then these regions were examined for genes based on the current set of T1DBase gene spans.

Region	Species	Chromosomal Location	Mb	Number of genes	Marker
2q24.2	Human	chr2:162960873..163392761	0.43	30	rs1990760

Other Regions: Available

Locus	Species	Chromosomal Location	Mb	Number of genes
Human 2q24.2 Orthologous Region	Rat	chr3:44401046..44815836	0.41	5
Human 2q24.2 Orthologous Region	Mouse	chr2:62285610..62714487	0.43	5

(Human) GRCh37 - chr2:162999385..163008914 (9.53 kb)  View in Genome Browser

(Mouse) NCBIM37 - chr2:62312587..62321710 (9.12 kb)  View in Genome Browser

(Rat) RGSC3.4 - chr3:44432447..44438004 (5.56 kb)  View in Genome Browser

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human Mouse Rat ductal cells exocrine pancreas pancreatic islets primary beta cells Pancreatic Islets MPSS beta cell line pancreatic islets whole pancreas alpha cell beta cell line pancreatic islets primary beta cells whole pancreas

Expression Legend   Range 0                                                                                                     100                                                                                                       No Data The Beta Cell Gene Atlas is a collection of almost all available public microarray data generated with pancreatic beta cells and related cell lines and types. The expression data comes from 131 array analyses derived from 28 experiments (open details in a new window). The basal (untreated cell) expression signal intensity values in each array were converted to ranks within the experiments; the highest value was used for genes represented by more than one probe. The rank values of genes in a given cell type were averaged with other calculated values from experiments performed with the same cell type. The rank transformation of the expression values enable comparison of gene expression across different organisms and tissues. A red border around a cell indicates greater certainty in the data; specifically, the gene has >0.95 probability of being expressed in the tissue.

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Range 0                                                                                                     100                                                                                                       No Data

Signal intensity values were converted to ranks within the experiments. For genes represented by more than one probeset, we averaged the intensity signals for each probeset across all tissues and chose the probeset with the highest average value. The rank transformation of the expression values enables comparison of gene expression across different organisms and tissues.

Interactions Table for GCG: The GCG interactions are shown below. Each row lists the two interactors, the sources which document this as an interaction, a classification of the interaction as empirical or predicted, and Pubmed IDs (if any) for the interaction. The table of interactions is downloadable as a text file. Please note that the text file will not include data from HPRD due to restrictions imposed by the HPRD funding sources. Interactor Interactor Sources Classification Pubmed IDs GCG   CPE   HPRD  empirical  11375130  GCG   CTSL1   HPRD  empirical  7340337  GCG   GCGR   HPRD, Reactome  empirical  8382034  15464082  8144028  2826231  11946536  GCG   GLP1R   HPRD, BioGRID, Reactome  empirical  11116211  GCG   MEP1A   HPRD  empirical  7340337  11278902  GCG   MEP1B   HPRD  empirical  11278902  GCG   GLP2R   HPRD, Reactome  empirical  11738243  15471943  10322410  9990065

View all

KEGG Network: 1   Neuroactive ligand-receptor interaction Human - 4080 Mouse - 4080 Rat - 4080

Biocarta: None available   None available.

Reactome: 14   Class B/2 (Secretin family receptors) REACT_18372 Diabetes pathways REACT_15380 G alpha (q) signalling events REACT_18283 G alpha (s) signalling events REACT_19327 Glucagon signaling in metabolic regulation REACT_1665 Glucagon-type ligand receptors REACT_18377 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Incretin Synthesis, Secretion, and Inactivation REACT_23974 Integration of energy metabolism REACT_1505 Regulation of Insulin Secretion REACT_18325 Regulation of Insulin Secretion by Glucagon-like Peptide-1 REACT_18274 Signaling by GPCR REACT_14797 Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) REACT_24019

NCI-Nature Pathway Interaction Database: 1   FOXA1 transcription factor network

Gene Ontology: 29   Receptor binding GO:0005102 Hormone activity GO:0005179 Extracellular region GO:0005576 Extracellular space GO:0005615 Soluble fraction GO:0005625 Cytoplasm GO:0005737 Endoplasmic reticulum lumen GO:0005788 Plasma membrane GO:0005886 Energy reserve metabolic process GO:0006112 Anti-apoptosis GO:0006916 Signal transduction GO:0007165 G-protein coupled receptor protein signaling pathway GO:0007186 G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 Feeding behavior GO:0007631 Cell proliferation GO:0008283 Protein kinase A signaling cascade GO:0010737 Positive regulation of peptidyl-threonine phosphorylation GO:0010800 Stored secretory granule GO:0030141 Positive regulation of cAMP biosynthetic process GO:0030819 Glucagon receptor binding GO:0031769 Positive regulation of protein binding GO:0032092 Negative regulation of appetite GO:0032099 Positive regulation of peptidyl-serine phosphorylation GO:0033138 Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 Positive regulation of protein kinase activity GO:0045860 Regulation of insulin secretion GO:0050796 Positive regulation of ERK1 and ERK2 cascade GO:0070374 Cellular response to glucagon stimulus GO:0071377 Positive regulation of calcium ion import GO:0090280

	KEGG Network: 1 Neuroactive ligand-receptor interaction Human - 4080 Mouse - 4080 Rat - 4080
	Biocarta: None available
	Reactome: 14 Class B/2 (Secretin family receptors) REACT_18372 Diabetes pathways REACT_15380 G alpha (q) signalling events REACT_18283 G alpha (s) signalling events REACT_19327 Glucagon signaling in metabolic regulation REACT_1665 Glucagon-type ligand receptors REACT_18377 GPCR downstream signaling REACT_19184 GPCR ligand binding REACT_21340 Incretin Synthesis, Secretion, and Inactivation REACT_23974 Integration of energy metabolism REACT_1505 Regulation of Insulin Secretion REACT_18325 Regulation of Insulin Secretion by Glucagon-like Peptide-1 REACT_18274 Signaling by GPCR REACT_14797 Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) REACT_24019
	NCI-Nature Pathway Interaction Database: 1 FOXA1 transcription factor network
	Gene Ontology: 29 Receptor binding GO:0005102 Hormone activity GO:0005179 Extracellular region GO:0005576 Extracellular space GO:0005615 Soluble fraction GO:0005625 Cytoplasm GO:0005737 Endoplasmic reticulum lumen GO:0005788 Plasma membrane GO:0005886 Energy reserve metabolic process GO:0006112 Anti-apoptosis GO:0006916 Signal transduction GO:0007165 G-protein coupled receptor protein signaling pathway GO:0007186 G-protein signaling, coupled to cAMP nucleotide second messenger GO:0007188 Feeding behavior GO:0007631 Cell proliferation GO:0008283 Protein kinase A signaling cascade GO:0010737 Positive regulation of peptidyl-threonine phosphorylation GO:0010800 Stored secretory granule GO:0030141 Positive regulation of cAMP biosynthetic process GO:0030819 Glucagon receptor binding GO:0031769 Positive regulation of protein binding GO:0032092 Negative regulation of appetite GO:0032099 Positive regulation of peptidyl-serine phosphorylation GO:0033138 Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 Positive regulation of protein kinase activity GO:0045860 Regulation of insulin secretion GO:0050796 Positive regulation of ERK1 and ERK2 cascade GO:0070374 Cellular response to glucagon stimulus GO:0071377 Positive regulation of calcium ion import GO:0090280

Type 1 Diabetes Publications: 263

• Glucagon-like Peptide 1 Stimulates Post-translational Activation of Glucokinase in Pancreatic {beta} Cells.
  Ding SY, Nkobena A, Kraft CA, Markwardt ML, Rizzo MA
  J Biol Chem. 2011
  PubMed ID: 21454584
   
  
• The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.
  Kim SY, Rane SG
  Development. 2011
  PubMed ID: 21490060
   
  
• Islet-1 regulates Arx transcription during pancreatic islet alpha-cell development.
  Liu J, Hunter CS, Du A, Ediger B, Walp E, Murray J, Stein R, May CL
  J Biol Chem. 2011
  PubMed ID: 21388963
   
  
• Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function.
  Barrera JG, Jones KR, Herman JP, D'Alessio DA, Woods SC, Seeley RJ
  J Neurosci. 2011
  PubMed ID: 21389245
   
  
• An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells.
  Ogaki S, Harada S, Shiraki N, Kume K, Kume S
  BMC Dev Biol. 2011
  PubMed ID: 21362171
   
  
• Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development.
  Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A
  Dev Dyn. 2011
  PubMed ID: 21287656
   
  
• Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.
  Stefan M, Simmons RA, Bertera S, Trucco MM, Esni F, Drain P, Nicholls RD
  Am J Physiol Endocrinol Metab. 2011
  PubMed ID: 21343540
   
  
• PPARβ/δ Activation Induces Enteroendocrine L Cell GLP-1 Production.
  Daoudi M, Hennuyer N, Borland MG, Touche V, Duhem C, Gross B, Caiazzo R, Kerr-Conte J, Pattou F, Peters JM, Staels B, Lestavel S
  Gastroenterology. 2011
  PubMed ID: 21300064
   
  
• α3(V) collagen is critical for glucose homeostasis in mice due to effects in pancreatic islets and peripheral tissues.
  Huang G, Ge G, Wang D, Gopalakrishnan B, Butz DH, Colman RJ, Nagy A, Greenspan DS
  J Clin Invest. 2011
  PubMed ID: 21293061
   
  
• The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas.
  Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, Guo P, El-Gohary Y, Malek M, Shah S, Gittes GK
  Diabetes. 2011
  PubMed ID: 21270265
   
  
• Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.
  Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M
  Development. 2011
  PubMed ID: 21266405
   
  
• Leptin downregulates expression of the gene encoding glucagon in alphaTC1-9 cells and mouse islets.
  Marroquí L, Vieira E, Gonzalez A, Nadal A, Quesada I
  Diabetologia. 2011
  PubMed ID: 21234744
   
  
• Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
  Miyatsuka T, Kosaka Y, Kim H, German MS
  Proc Natl Acad Sci U S A. 2011
  PubMed ID: 21173230
   
  
• Dachshund homologues play a conserved role in islet cell development.
  Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS
  Dev Biol. 2010
  PubMed ID: 20869363
   
  
• Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation.
  Plank JL, Mundell NA, Frist AY, Legrone AW, Kim T, Musser MA, Walter TJ, Labosky PA
  Dev Biol. 2010
  PubMed ID: 21081123
   
  
• Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny.
  Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, Yamada S, Kudva Y, Terzic A, Ikeda Y
  Gene Ther. 2010
  PubMed ID: 21048796
   
  
• A role for islet somatostatin in mediating sympathetic regulation of glucagon secretion.
  Hauge-Evans AC, King AJ, Fairhall K, Persaud SJ, Jones PM
  Islets. 2010
  PubMed ID: 21099335
   
  
• Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.
  Claiborn KC, Sachdeva MM, Cannon CE, Groff DN, Singer JD, Stoffers DA
  J Clin Invest. 2010
  PubMed ID: 20811152
   
  
• Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice.
  Valtat B, Dupuis C, Zenaty D, Singh-Estivalet A, Tronche F, Bréant B, Blondeau B
  Diabetologia. 2010
  PubMed ID: 20857084
   
  
• A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system.
  Zielonka M, Xia J, Friedel RH, Offermanns S, Worzfeld T
  Exp Cell Res. 2010
  PubMed ID: 20478304
   
  
• Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes.
  Christensen M, Knop FK, Vilsbøll T, Aaboe K, Holst JJ, Madsbad S, Krarup T
  Regul Pept. 2010
  PubMed ID: 20580750
   
  
• MafA and MafB Regulate Genes Critical to {beta} Cells in a Unique Temporal Manner.
  Artner I, Hang Y, Mazur M, Yamamoto T, Guo M, Lindner J, Magnuson MA, Stein R
  Diabetes. 2010
  PubMed ID: 20627934
   
  
• G{alpha}o represses insulin secretion by reducing vesicular docking in pancreatic {beta} cells.
  Zhao A, Ohara-Imaizumi M, Brissova M, Benniger RK, Xu Y, Hao Y, Abramowitz J, Boulay G, Powers AC, Piston D, Jiang M, Nagamatsu S, Birnbaumer L, Gu G
  Diabetes. 2010
  PubMed ID: 20622165
   
  
• Systemic Delivery of Bioactive Glucagon-Like Peptide 1 after Adenoviral-Mediated Gene Transfer in the Murine Salivary Gland.
  Voutetakis A, Cotrim AP, Rowzee A, Zheng C, Rathod T, Yanik T, Loh YP, Baum BJ, Cawley NX
  Endocrinology. 2010
  PubMed ID: 20610567
   
  
• N-cadherin is dispensable for pancreas development but required for beta-cell granule turnover.
  Johansson JK, Voss U, Kesavan G, Kostetskii I, Wierup N, Radice GL, Semb H
  Genesis. 2010
  PubMed ID: 20533404
   
  
• Minireview: update on incretin biology: focus on glucagon-like peptide-1.
  Brubaker PL
  Endocrinology. 2010
  PubMed ID: 20305008
   
  
• Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function.
  Lau J, Hebrok M
  Diabetes. 2010
  PubMed ID: 20185815
   
  
• Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression.
  Martin B, Shin YK, White CM, Ji S, Kim W, Carlson OD, Napora JK, Chadwick W, Chapter M, Waschek JA, Mattson MP, Maudsley S, Egan JM
  Diabetes. 2010
  PubMed ID: 20150284
   
  
• The transcription factor Rfx3 regulates {beta}-cell differentiation, function and glucokinase expression.
  Ait-Lounis A, Bonal C, Seguín-Estévez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W
  Diabetes. 2010
  PubMed ID: 20413507
   
  
• Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.
  Bjerre Knudsen L, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, Gotfredsen C, Egerod FL, Hegelund AC, Jacobsen H, Jacobsen SD, Moses AC, Mølck AM, Nielsen HS, Nowak J, Solberg H, Thi TD, Zdravkovic M
  Endocrinology. 2010
  PubMed ID: 20203154
   
  
• Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4.
  Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H
  Diabetes. 2010
  PubMed ID: 20068138
   
  
• Rfx6 directs islet formation and insulin production in mice and humans.
  Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Eijnden SV, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS
  Nature. 2010
  PubMed ID: 20148032
   
  
• Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.
  Galbo T, Pedersen IL, Fløyel T, Bang-Berthelsen CH, Serup P, Madsen OD, Hald J
  Eur J Histochem. 2010
  PubMed ID: 20558340
   
  
• Relative roles of the different Pax6 domains for pancreatic alpha cell development.
  Dames P, Puff R, Weise M, Parhofer KG, Göke B, Götz M, Graw J, Favor J, Lechner A
  BMC Dev Biol. 2010
  PubMed ID: 20377917
   
  
• Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas.
  Kopinke D, Murtaugh LC
  BMC Dev Biol. 2010
  PubMed ID: 20377894
   
  
• SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells.
  Li S, Francisco AB, Munroe RJ, Schimenti JC, Long Q
  BMC Dev Biol. 2010
  PubMed ID: 20170518
   
  
• Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.
  Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, Ravassard P, Vermot J, Voz ML, Mellitzer G, Gradwohl G
  Development. 2010
  PubMed ID: 20040487
   
  
• Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas.
  Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G
  Dev Biol. 2009
  PubMed ID: 20025861
   
  
• Glucagon Like Peptide-1-Directed Human Embryonic Stem Cells Differentiation Into Insulin-Producing Cells Via Hedgehog, cAMP, and PI3K Pathways.
  Hui H, Tang YG, Zhu L, Khoury N, Hui Z, Wang KY, Perfetti R, Go VL
  Pancreas. 2009
  PubMed ID: 19924023
   
  
• GLP-1 mediates anti-apoptotic effect by phosphorylating bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic [beta]-cells.
  Quoyer J, Longuet C, Broca C, Linck N, Costes S, Varin E, Bockaert J, Bertrand G, Dalle S
  J Biol Chem. 2009
  PubMed ID: 19915011
   
  
• Pancreatic neurogenin 3-expressing cells are unipotent islet precursors.
  Desgraz R, Herrera PL
  Development. 2009
  PubMed ID: 19793886
   
  
• OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas.
  Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A
  Diabetologia. 2009
  PubMed ID: 19882138
   
  
• Mice Deficient for Glucagon Gene-Derived Peptides Display Normoglycemia and Hyperplasia of Islet {alpha}-Cells But Not of Intestinal L-Cells.
  Hayashi Y, Yamamoto M, Mizoguchi H, Watanabe C, Ito R, Yamamoto S, Sun XY, Murata Y
  Mol Endocrinol. 2009
  PubMed ID: 19819987
   
  
• Transcription factor Glis3: a novel critical player in the regulation of pancreatic {beta}-cell development and insulin gene expression.
  Kang HS, Kim YS, Zeruth G, Beak JY, Gerrish K, Kilic G, Sosa-Pineda B, Jensen J, Foley J, Jetten AM
  Mol Cell Biol. 2009
  PubMed ID: 19805515
   
  
• Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice.
  Wu X, Wang L, Schroer S, Choi D, Chen P, Okada H, Woo M
  Diabetologia. 2009
  PubMed ID: 19644667
   
  
• Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.
  Westmoreland JJ, Wang Q, Bouzaffour M, Baker SJ, Sosa-Pineda B
  Dev Biol. 2009
  PubMed ID: 19635472
   
  
• Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.
  Zhang H, Ables ET, Pope CF, Washington MK, Hipkens S, Means AL, Path G, Seufert J, Costa RH, Leiter AB, Magnuson MA, Gannon M
  Mech Dev. 2009
  PubMed ID: 19766716
   
  
• Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) BY NkX2.2 and neurogenin 3.
  Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L
  J Biol Chem. 2009
  PubMed ID: 19759004
   
  
• Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
  Cras-Méneur C, Li L, Kopan R, Permutt MA
  Genes Dev. 2009
  PubMed ID: 19723764
   
  
• Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells.
  Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ
  Cell Metab. 2009
  PubMed ID: 19583950
   
  
• Islet-1 is required for the maturation, proliferation and survival of the endocrine pancreas.
  Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL
  Diabetes. 2009
  PubMed ID: 19502415
   
  
• Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
  Nicolson TJ, Bellomo EA, Wijesekara N, Loder MK, Baldwin JM, Gyulkhandanyan AV, Koshkin V, Tarasov AI, Carzaniga R, Kronenberger K, Taneja TK, da Silva Xavier G, Libert S, Froguel P, Scharfmann R, Stetsyuk V, Ravassard P, Parker H, Gribble FM, Reimann F, Sladek R, Hughes SJ, Johnson PR, Masseboeuf M, Burcelin R, Baldwin SA, Liu M, Lara-Lemus R, Arvan P, Schuit FC, Wheeler MB, Chimienti F, Rutter GA
  Diabetes. 2009
  PubMed ID: 19542200
   
  
• The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice.
  Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA
  J Clin Invest. 2009
  PubMed ID: 19487809
   
  
• Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function.
  Wang S, Jensen JN, Seymour PA, Hsu W, Dor Y, Sander M, Magnuson MA, Serup P, Gu G
  Proc Natl Acad Sci U S A. 2009
  PubMed ID: 19487660
   
  
• Immunohistochemical localization of glucagon and pancreatic polypeptide on rat endocrine pancreas: coexistence in rat islet cells.
  Huang YH, Sun MJ, Jiang M, Fu BY
  Eur J Histochem. 2009
  PubMed ID: 19683981
   
  
• Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and {beta}-Cell Proliferation during Embryogenesis.
  Crawford LA, Guney MA, Oh YA, Deyoung RA, Valenzuela DM, Murphy AJ, Yancopoulos GD, Lyons KM, Brigstock DR, Economides A, Gannon M
  Mol Endocrinol. 2009
  PubMed ID: 19131512
   
  
• Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
  Fujita Y, Wideman RD, Speck M, Asadi A, King DS, Webber TD, Haneda M, Kieffer TJ
  Am J Physiol Endocrinol Metab. 2009
  PubMed ID: 19106249
   
  
• Nutrient-driven incretin secretion into intestinal lymph is different between diabetic Goto-Kakizaki rats and Wistar rats.
  Kindel TL, Yang Q, Yoder SM, Tso P
  Am J Physiol Gastrointest Liver Physiol. 2009
  PubMed ID: 19056762
   
  
• Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.
  Egido EM, Hernández R, Marco J, Silvestre RA
  Regul Pept. 2009
  PubMed ID: 18773927
   
  
• Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice.
  Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL
  Gastroenterology. 2009
  PubMed ID: 19022256
   
  
• Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development.
  Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH
  Genes Dev. 2008
  PubMed ID: 19141476
   
  
• Autoreactive T-cell receptor (Vbeta/D/Jbeta) sequences in diabetes are homologous to insulin, glucagon, the insulin receptor, and the glucagon receptor.
  Root-Bernstein R
  J Mol Recognit. 2008
  PubMed ID: 19051206
   
  
• A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
  Seymour PA, Freude KK, Dubois CL, Shih HP, Patel NA, Sander M
  Dev Biol. 2008
  PubMed ID: 18723011
   
  
• Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes.
  Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ
  J Clin Invest. 2008
  PubMed ID: 18776938
   
  
• Conditional inactivation of Myc impairs development of the exocrine pancreas.
  Nakhai H, Siveke JT, Mendoza-Torres L, Schmid RM
  Development. 2008
  PubMed ID: 18715949
   
  
• Tumour suppressor MENIN is essential for development ofthe pancreatic endocrine cells.
  Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang C
  J Endocrinol. 2008
  PubMed ID: 18772165
   
  
• Glucose and GLP-1 Stimulate cAMP Production via Distinct Adenylyl Cyclases in INS-1E Insulinoma Cells.
  Ramos LS, Zippin JH, Kamenetsky M, Buck J, Levin LR
  J Gen Physiol. 2008
  PubMed ID: 18695009
   
  
• Conditional ablation of Notch signaling in pancreatic development.
  Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM
  Development. 2008
  PubMed ID: 18635610
   
  
• The mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3 null mouse.
  Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC
  Diabetes. 2008
  PubMed ID: 18599526
   
  
• Postnatal expansion of the pancreatic {beta}-cell mass is dependent on survivin.
  Jiang Y, Nishimura W, Devor-Henneman D, Kusewitt D, Wang H, Holloway MP, Dohi T, Sabo E, Robinson ML, Altieri DC, Sharma A, Altura RA
  Diabetes. 2008
  PubMed ID: 18599523
   
  
• Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice.
  Fukuda A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CV, Hoshino M, Chiba T, Uemoto S
  Diabetes. 2008
  PubMed ID: 18591390
   
  
• Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation.
  Jonckheere N, Mayes E, Shih HP, Li B, Lioubinski O, Dai X, Sander M
  Dev Biol. 2008
  PubMed ID: 18452912
   
  
• Identification of transcripts with enriched expression in the developing and adult pancreas.
  Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones S, Marra MA, Helgason CD
  Genome Biol. 2008
  PubMed ID: 18554416
   
  
• Gpr40 is expressed in enteroendocrine cells and mediates FFA stimulation of incretin secretion.
  Edfalk S, Steneberg P, Edlund H
  Diabetes. 2008
  PubMed ID: 18519800
   
  
• Signals from the neural crest regulate beta-cell mass in the pancreas.
  Nekrep N, Wang J, Miyatsuka T, German MS
  Development. 2008
  PubMed ID: 18506029
   
  
• Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation.
  Wang S, Hecksher-Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, Serup P, Gu G
  Dev Biol. 2008
  PubMed ID: 18394599
   
  
• Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions.
  Koma Y, Furuno T, Hagiyama M, Hamaguchi K, Nakanishi M, Masuda M, Hirota S, Yokozaki H, Ito A
  Gastroenterology. 2008
  PubMed ID: 18471525
   
  
• Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells.
  Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA
  Dev Biol. 2008
  PubMed ID: 18294628
   
  
• Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
  Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA
  Mol Cell Biol. 2008
  PubMed ID: 18227155
   
  
• Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
  Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A
  Dev Biol. 2008
  PubMed ID: 18199433
   
  
• pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.
  Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV
  Dev Biol. 2008
  PubMed ID: 18155690
   
  
• Expression of Groucho/TLE proteins during pancreas development.
  Hoffman BG, Zavaglia B, Beach M, Helgason CD
  BMC Dev Biol. 2008
  PubMed ID: 18778483
   
  
• Gene expression profiling of a mouse model of pancreatic islet dysmorphogenesis.
  Wilding Crawford L, Tweedie Ables E, Oh YA, Boone B, Levy S, Gannon M
  PLoS ONE. 2008
  PubMed ID: 18297134
   
  
• The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas.
  Hamblet NS, Shi W, Vinik AI, Taylor-Fishwick DA
  Pancreas. 2008
  PubMed ID: 18192873
   
  
• Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum.
  Wang Q, Elghazi L, Martin S, Martins I, Srinivasan RS, Geng X, Sleeman M, Collombat P, Houghton J, Sosa-Pineda B
  Dev Dyn. 2008
  PubMed ID: 18058910
   
  
• Expression of HNF-4alpha (MODY1), HNF-1beta (MODY5), and HNF-1alpha (MODY3) proteins in the developing mouse pancreas.
  Nammo T, Yamagata K, Tanaka T, Kodama T, Sladek FM, Fukui K, Katsube F, Sato Y, Miyagawa J, Shimomura I
  Gene Expr Patterns. 2008
  PubMed ID: 17996499
   
  
• Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells.
  Chao CS, Loomis ZL, Lee JE, Sussel L
  Dev Biol. 2007
  PubMed ID: 17988662
   
  
• Pancreatic innervation in mouse development and beta-cell regeneration.
  Burris RE, Hebrok M
  Neuroscience. 2007
  PubMed ID: 18006238
   
  
• Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon.
  Salehi A, Qader SS, Grapengiesser E, Hellman B
  Regul Pept. 2007
  PubMed ID: 17628719
   
  
• MicroRNA expression is required for pancreatic islet cell genesis in the mouse.
  Lynn FC, Skewes-Cox P, Kosaka Y, McManus MT, Harfe BD, German MS
  Diabetes. 2007
  PubMed ID: 17804764
   
  
• Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression.
  Gosmain Y, Avril I, Mamin A, Philippe J
  J Biol Chem. 2007
  PubMed ID: 17901057
   
  
• MicroRNA profiling of developing and regenerating pancreas reveal post-transcriptional regulation of neurogenin3.
  Joglekar MV, Parekh VS, Mehta S, Bhonde RR, Hardikar AA
  Dev Biol. 2007
  PubMed ID: 17936263
   
  
• Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse.
  Wang S, Zhang J, Zhao A, Hipkens S, Magnuson MA, Gu G
  Mech Dev. 2007
  PubMed ID: 17928203
   
  
• Association of fasting glucagon and proinsulin concentrations with insulin resistance.
  Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K, Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators
  Diabetologia. 2007
  PubMed ID: 17846745
   
  
• A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice.
  Wideman RD, Covey SD, Webb GC, Drucker DJ, Kieffer TJ
  Diabetes. 2007
  PubMed ID: 17698597
   
  
• Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
  Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ
  Genes Dev. 2007
  PubMed ID: 17938243
   
  
• Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets.
  Goto Y, Nomura M, Tanaka K, Kondo A, Morinaga H, Okabe T, Yanase T, Nawata H, Takayanagi R, Li E
  Dev Dyn. 2007
  PubMed ID: 17849440
   
  
• GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion.
  Cani PD, Holst JJ, Drucker DJ, Delzenne NM, Thorens B, Burcelin R, Knauf C
  Mol Cell Endocrinol. 2007
  PubMed ID: 17681422
   
  
• Endocrine regulation of energy metabolism by the skeleton.
  Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G
  Cell. 2007
  PubMed ID: 17693256
   
  
• Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.
  Strom A, Bonal C, Ashery-Padan R, Hashimoto N, Campos ML, Trumpp A, Noda T, Kido Y, Real FX, Thorel F, Herrera PL
  Development. 2007
  PubMed ID: 17596282
   
  
• Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis.
  Marzioni M, Alpini G, Saccomanno S, Candelaresi C, Venter J, Rychlicki C, Fava G, Francis H, Trozzi L, Glaser S, Benedetti A
  Gastroenterology. 2007
  PubMed ID: 17631146
   
  
• The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
  Nelson SB, Schaffer AE, Sander M
  Development. 2007
  PubMed ID: 17537793
   
  
• A role of FRK in regulation of embryonal pancreatic beta cell formation.
  Akerblom B, Annerén C, Welsh M
  Mol Cell Endocrinol. 2007
  PubMed ID: 17416457
   
  
• TGF-beta isoform signaling regulates secondary transition and mesenchymal-induced endocrine development in the embryonic mouse pancreas.
  Tulachan SS, Tei E, Hembree M, Crisera C, Prasadan K, Koizumi M, Shah S, Guo P, Bottinger E, Gittes GK
  Dev Biol. 2007
  PubMed ID: 17418116
   
  
• Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells.
  Fujiwara K, Maekawa F, Dezaki K, Nakata M, Yashiro T, Yada T
  Endocrinology. 2007
  PubMed ID: 17289853
   
  
• Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.
  Collombat P, Hecksher-Sørensen J, Krull J, Berger J, Riedel D, Herrera PL, Serup P, Mansouri A
  J Clin Invest. 2007
  PubMed ID: 17404619
   
  
• Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.
  Kedees MH, Guz Y, Vuguin PM, Vargas C, Cui L, Steiner DF, Charron MJ, Teitelman G
  Dev Dyn. 2007
  PubMed ID: 17366624
   
  
• A novel element regulates expression of the proximal human proglucagon promoter in islet cells.
  Tsai B, Yue S, Irwin DM
  Gen Comp Endocrinol. 2007
  PubMed ID: 17324423
   
  
• MafB is required for islet beta cell maturation.
  Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17360442
   
  
• BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
  Goulley J, Dahl U, Baeza N, Mishina Y, Edlund H
  Cell Metab. 2007
  PubMed ID: 17339028
   
  
• Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
  Doyle MJ, Loomis ZL, Sussel L
  Development. 2007
  PubMed ID: 17202186
   
  
• Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas.
  Rukstalis JM, Habener JF
  Gene Expr Patterns. 2007
  PubMed ID: 17185046
   
  
• Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells.
  Vieira E, Salehi A, Gylfe E
  Diabetologia. 2007
  PubMed ID: 17136393
   
  
• Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells.
  Svensson P, Williams C, Lundeberg J, Rydén P, Bergqvist I, Edlund H
  BMC Dev Biol. 2007
  PubMed ID: 18036209
   
  
• Wnt/beta-catenin signaling is required for development of the exocrine pancreas.
  Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM
  BMC Dev Biol. 2007
  PubMed ID: 17222338
   
  
• FGFR3 is a negative regulator of the expansion of pancreatic epithelial cells.
  Arnaud-Dabernat S, Kritzik M, Kayali AG, Zhang YQ, Liu G, Ungles C, Sarvetnick N
  Diabetes. 2007
  PubMed ID: 17192470
   
  
• Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1.
  Liu MJ, Shin S, Li N, Shigihara T, Lee YS, Yoon JW, Jun HS
  Mol Ther. 2007
  PubMed ID: 17164779
   
  
• Activin A decreases glucagon and arx gene expression in alpha-cell lines.
  Mamin A, Philippe J
  Mol Endocrinol. 2007
  PubMed ID: 16988001
   
  
• FoxO1 is required for the regulation of preproglucagon gene expression by insulin in pancreatic alphaTC1-9 cells.
  McKinnon CM, Ravier MA, Rutter GA
  J Biol Chem. 2006
  PubMed ID: 17062568
   
  
• Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.
  Zhang X, Rowan S, Yue Y, Heaney S, Pan Y, Brendolan A, Selleri L, Maas RL
  Dev Biol. 2006
  PubMed ID: 17049510
   
  
• PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.
  Zhang W, Feng D, Li Y, Iida K, McGrath B, Cavener DR
  Cell Metab. 2006
  PubMed ID: 17141632
   
  
• Glucocorticoid signalling affects pancreatic development through both direct and indirect effects.
  Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B
  Diabetologia. 2006
  PubMed ID: 17001468
   
  
• Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function.
  Brissova M, Shostak A, Shiota M, Wiebe PO, Poffenberger G, Kantz J, Chen Z, Carr C, Jerome WG, Chen J, Baldwin HS, Nicholson W, Bader DM, Jetton T, Gannon M, Powers AC
  Diabetes. 2006
  PubMed ID: 17065333
   
  
• p27 Regulates the transition of beta-cells from quiescence to proliferation.
  Georgia S, Bhushan A
  Diabetes. 2006
  PubMed ID: 17065330
   
  
• Analysis of pancreatic endocrine development in GDF11-deficient mice.
  Dichmann DS, Yassin H, Serup P
  Dev Dyn. 2006
  PubMed ID: 16964608
   
  
• Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression.
  Boyer DF, Fujitani Y, Gannon M, Powers AC, Stein RW, Wright CV
  Dev Biol. 2006
  PubMed ID: 16962573
   
  
• Gata6 is an important regulator of mouse pancreas development.
  Decker K, Goldman DC, Grasch CL, Sussel L
  Dev Biol. 2006
  PubMed ID: 16887115
   
  
• p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors.
  Georgia S, Soliz R, Li M, Zhang P, Bhushan A
  Dev Biol. 2006
  PubMed ID: 16899237
   
  
• Conditional inactivation of the murine serum response factor in the pancreas leads to severe pancreatitis.
  Miralles F, Hebrard S, Lamotte L, Durel B, Gilgenkrantz H, Li Z, Daegelen D, Tuil D, Joshi RL
  Lab Invest. 2006
  PubMed ID: 16894357
   
  
• Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.
  Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA
  Gene Expr Patterns. 2006
  PubMed ID: 16750430
   
  
• Glucagon-like peptide 1 activates protein kinase C through Ca2+-dependent activation of phospholipase C in insulin-secreting cells.
  Suzuki Y, Zhang H, Saito N, Kojima I, Urano T, Mogami H
  J Biol Chem. 2006
  PubMed ID: 16870611
   
  
• The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3.
  Xu Y, Wang S, Zhang J, Zhao A, Stanger BZ, Gu G
  Dev Biol. 2006
  PubMed ID: 16920096
   
  
• The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
  Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C
  Genes Dev. 2006
  PubMed ID: 16951258
   
  
• Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
  Vuguin PM, Kedees MH, Cui L, Guz Y, Gelling RW, Nejathaim M, Charron MJ, Teitelman G
  Endocrinology. 2006
  PubMed ID: 16627579
   
  
• The FoxM1 transcription factor is required to maintain pancreatic beta-cell mass.
  Zhang H, Ackermann AM, Gusarova GA, Lowe D, Feng X, Kopsombut UG, Costa RH, Gannon M
  Mol Endocrinol. 2006
  PubMed ID: 16556734
   
  
• Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagon-like peptide-1.
  Li LX, MacDonald PE, Ahn DS, Oudit GY, Backx PH, Brubaker PL
  Endocrinology. 2006
  PubMed ID: 16574789
   
  
• Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin.
  List JF, He H, Habener JF
  Regul Pept. 2006
  PubMed ID: 16631262
   
  
• A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
  Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A
  Dev Biol. 2006
  PubMed ID: 16580660
   
  
• Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes.
  Stiles BL, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H
  Mol Cell Biol. 2006
  PubMed ID: 16537919
   
  
• IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
  Mellitzer G, Bonné S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, Nielsen FC, Ferrer J, Gradwohl G, Heimberg H
  EMBO J. 2006
  PubMed ID: 16511571
   
  
• MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
  Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R
  Diabetes. 2006
  PubMed ID: 16443760
   
  
• Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.
  Smart NG, Apelqvist AA, Gu X, Harmon EB, Topper JN, MacDonald RJ, Kim SK
  PLoS Biol. 2006
  PubMed ID: 16435884
   
  
• Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation.
  Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV
  Genes Dev. 2006
  PubMed ID: 16418487
   
  
• Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas.
  Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K
  Cell Metab. 2006
  PubMed ID: 16399505
   
  
• Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.
  De León DD, Crutchlow MF, Ham JY, Stoffers DA
  Int J Biochem Cell Biol. 2006
  PubMed ID: 16202636
   
  
• Endodermal expression of Nkx6 genes depends differentially on Pdx1.
  Pedersen JK, Nelson SB, Jorgensen MC, Henseleit KD, Fujitani Y, Wright CV, Sander M, Serup P, Beta Cell Biology Consortium
  Dev Biol. 2005
  PubMed ID: 16297379
   
  
• Altered Glut-2 accumulation and beta-cell function in mice lacking the exocrine-specific transcription factor, Mist1.
  Fazio EN, Everest M, Colman R, Wang R, Pin CL
  J Endocrinol. 2005
  PubMed ID: 16423820
   
  
• Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation.
  Akpinar P, Kuwajima S, Krützfeldt J, Stoffel M
  Cell Metab. 2005
  PubMed ID: 16330324
   
  
• The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
  Wilson ME, Yang KY, Kalousova A, Lau J, Kosaka Y, Lynn FC, Wang J, Mrejen C, Episkopou V, Clevers HC, German MS
  Diabetes. 2005
  PubMed ID: 16306355
   
  
• Biologic actions and therapeutic potential of the proglucagon-derived peptides.
  Drucker DJ
  Nat Clin Pract Endocrinol Metab. 2005
  PubMed ID: 16929363
   
  
• Beta-catenin is essential for pancreatic acinar but not islet development.
  Murtaugh LC, Law AC, Dor Y, Melton DA
  Development. 2005
  PubMed ID: 16192304
   
  
• Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.
  Papadopoulou S, Edlund H
  Diabetes. 2005
  PubMed ID: 16186384
   
  
• Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells.
  Diao J, Asghar Z, Chan CB, Wheeler MB
  J Biol Chem. 2005
  PubMed ID: 16027126
   
  
• Pancreas-specific deletion of beta-catenin reveals Wnt-dependent and Wnt-independent functions during development.
  Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A
  Curr Biol. 2005
  PubMed ID: 16169491
   
  
• Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.
  Koizumi M, Doi R, Fujimoto K, Ito D, Toyoda E, Mori T, Kami K, Kawaguchi Y, Gittes GK, Imamura M
  Surgery. 2005
  PubMed ID: 16153418
   
  
• Synergistic endocrine induction by GLP-1 and TGF-beta in the developing pancreas.
  Tei E, Mehta S, Tulachan SS, Yew H, Hembree M, Preuett B, Snyder CL, Yamataka A, Miyano T, Gittes GK
  Pancreas. 2005
  PubMed ID: 16025000
   
  
• Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight.
  Schou JH, Pilgaard K, Vilsbøll T, Jensen CB, Deacon CF, Holst JJ, Vølund A, Madsbad S, Vaag AA
  J Clin Endocrinol Metab. 2005
  PubMed ID: 15899957
   
  
• NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas.
  Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M
  Development. 2005
  PubMed ID: 15944193
   
  
• The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas.
  Collombat P, Hecksher-Sørensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A
  Development. 2005
  PubMed ID: 15930104
   
  
• Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
  Li L, El-Kholy W, Rhodes CJ, Brubaker PL
  Diabetologia. 2005
  PubMed ID: 15902400
   
  
• Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets.
  Rosanas-Urgell A, Marfany G, Garcia-Fernàndez J
  Mol Cell Endocrinol. 2005
  PubMed ID: 15888377
   
  
• GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.
  Hansotia T, Drucker DJ
  Regul Pept. 2005
  PubMed ID: 15780432
   
  
• [Expression of Nestin, CK19, insulin, glucagon and somatostatin in embryonic pancreas]
  Yan KM, Li AD, Yang HJ, Mei Y, Zhou HY
  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005
  PubMed ID: 16736556
   
  
• Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs.
  D'Amico E, Hui H, Khoury N, Di Mario U, Perfetti R
  J Mol Endocrinol. 2005
  PubMed ID: 15821104
   
  
• Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.
  Chu K, Tsai MJ
  Diabetes. 2005
  PubMed ID: 15793245
   
  
• Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments.
  Asayesh A, Alanentalo T, Khoo NK, Ahlgren U
  Dev Dyn. 2005
  PubMed ID: 15739225
   
  
• Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
  Perez SE, Cano DA, Dao-Pick T, Rougier JP, Werb Z, Hebrok M
  Diabetes. 2005
  PubMed ID: 15734845
   
  
• The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression.
  Ritz-Laser B, Mamin A, Brun T, Avril I, Schwitzgebel VM, Philippe J
  Mol Endocrinol. 2005
  PubMed ID: 15539431
   
  
• Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription.
  Schinner S, Barthel A, Dellas C, Grzeskowiak R, Sharma SK, Oetjen E, Blume R, Knepel W
  J Biol Chem. 2005
  PubMed ID: 15590659
   
  
• Foxa2 is required for the differentiation of pancreatic alpha-cells.
  Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH
  Dev Biol. 2005
  PubMed ID: 15680365
   
  
• Diabetes outfoxed by GLP-1?
  Holz GG, Chepurny OG
  Sci STKE. 2005
  PubMed ID: 15671479
   
  
• Wnt5 signaling in vertebrate pancreas development.
  Kim HJ, Schleiffarth JR, Jessurun J, Sumanas S, Petryk A, Lin S, Ekker SC
  BMC Biol. 2005
  PubMed ID: 16246260
   
  
• Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
  Flock G, Cao X, Drucker DJ
  Endocrinology. 2005
  PubMed ID: 15471960
   
  
• Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
  Ma X, Zhang Y, Gromada J, Sewing S, Berggren PO, Buschard K, Salehi A, Vikman J, Rorsman P, Eliasson L
  Mol Endocrinol. 2005
  PubMed ID: 15459251
   
  
• Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.
  Baggio LL, Kim JG, Drucker DJ
  Diabetes. 2004
  PubMed ID: 15561912
   
  
• GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development.
  Harmon EB, Apelqvist AA, Smart NG, Gu X, Osborne DH, Kim SK
  Development. 2004
  PubMed ID: 15548585
   
  
• Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.
  Baggio LL, Drucker DJ
  Best Pract Res Clin Endocrinol Metab. 2004
  PubMed ID: 15533774
   
  
• Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice.
  Mellitzer G, Martín M, Sidhoum-Jenny M, Orvain C, Barths J, Seymour PA, Sander M, Gradwohl G
  Mol Endocrinol. 2004
  PubMed ID: 15297605
   
  
• Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
  Lamotte L, Jackerott M, Bucchini D, Jami J, Joshi RL, Deltour L
  Transgenic Res. 2004
  PubMed ID: 15587270
   
  
• Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.
  Georgia S, Bhushan A
  J Clin Invest. 2004
  PubMed ID: 15467835
   
  
• Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM.
  Ma D, Shield JP, Dean W, Leclerc I, Knauf C, Burcelin R R, Rutter GA, Kelsey G
  J Clin Invest. 2004
  PubMed ID: 15286800
   
  
• Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells.
  Zhang YQ, Cleary MM, Si Y, Liu G, Eto Y, Kritzik M, Dabernat S, Kayali AG, Sarvetnick N
  Diabetes. 2004
  PubMed ID: 15277382
   
  
• Altered proglucagon processing in an alpha-cell line derived from prohormone convertase 2 null mouse islets.
  Webb GC, Dey A, Wang J, Stein J, Milewski M, Steiner DF
  J Biol Chem. 2004
  PubMed ID: 15143067
   
  
• Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization.
  Cano DA, Murcia NS, Pazour GJ, Hebrok M
  Development. 2004
  PubMed ID: 15226261
   
  
• Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans.
  Dalle S, Longuet C, Costes S, Broca C, Faruque O, Fontés G, Hani EH, Bataille D
  J Biol Chem. 2004
  PubMed ID: 14988413
   
  
• Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
  Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, Degerman E, Ahrén B, Holst LS
  J Biol Chem. 2004
  PubMed ID: 14736883
   
  
• Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development.
  Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L
  Proc Natl Acad Sci U S A. 2004
  PubMed ID: 14970313
   
  
• Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.
  Zaiko M, Estreicher A, Ritz-Laser B, Herrera P, Favor J, Meda P, Philippe J
  Eur J Endocrinol. 2004
  PubMed ID: 15012626
   
  
• The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation.
  Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B
  Dev Biol. 2004
  PubMed ID: 14729487
   
  
• The role of GLP-1 in the regulation of islet cell mass.
  Bulotta A, Farilla L, Hui H, Perfetti R
  Cell Biochem Biophys. 2004
  PubMed ID: 15289644
   
  
• Conversion of biliary system to pancreatic tissue in Hes1-deficient mice.
  Sumazaki R, Shiojiri N, Isoyama S, Masu M, Keino-Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A
  Nat Genet. 2004
  PubMed ID: 14702043
   
  
• Global expression analysis of gene regulatory pathways during endocrine pancreatic development.
  Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA
  Development. 2004
  PubMed ID: 14660441
   
  
• Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
  Maestro MA, Boj SF, Luco RF, Pierreux CE, Cabedo J, Servitja JM, German MS, Rousseau GG, Lemaigre FP, Ferrer J
  Hum Mol Genet. 2003
  PubMed ID: 14570708
   
  
• Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
  Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R
  Endocrinology. 2003
  PubMed ID: 12960095
   
  
• Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy.
  Mundinger TO, Mei Q, Figlewicz DP, Lernmark A, Taborsky GJ
  Am J Physiol Endocrinol Metab. 2003
  PubMed ID: 12876072
   
  
• Opposing actions of Arx and Pax4 in endocrine pancreas development.
  Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P
  Genes Dev. 2003
  PubMed ID: 14561778
   
  
• Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas.
  Yoshida T, Tokunaga A, Nakao K, Okano H
  Differentiation. 2003
  PubMed ID: 14641329
   
  
• Combined activities of hedgehog signaling inhibitors regulate pancreas development.
  Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M
  Development. 2003
  PubMed ID: 12917290
   
  
• Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.
  Vincent M, Guz Y, Rozenberg M, Webb G, Furuta M, Steiner D, Teitelman G
  Endocrinology. 2003
  PubMed ID: 12933680
   
  
• Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
  Hald J, Hjorth JP, German MS, Madsen OD, Serup P, Jensen J
  Dev Biol. 2003
  PubMed ID: 12921743
   
  
• Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number.
  Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M
  Oncogene. 2003
  PubMed ID: 12917627
   
  
• Expression of Sox transcription factors in the developing mouse pancreas.
  Lioubinski O, Müller M, Wegner M, Sander M
  Dev Dyn. 2003
  PubMed ID: 12815626
   
  
• Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway.
  Hui H, Nourparvar A, Zhao X, Perfetti R
  Endocrinology. 2003
  PubMed ID: 12639928
   
  
• Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis.
  Drucker DJ
  Mol Endocrinol. 2003
  PubMed ID: 12554744
   
  
• cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.
  Gomez E, Pritchard C, Herbert TP
  J Biol Chem. 2002
  PubMed ID: 12364324
   
  
• Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.
  Bulotta A, Hui H, Anastasi E, Bertolotto C, Boros LG, Di Mario U, Perfetti R
  J Mol Endocrinol. 2002
  PubMed ID: 12459036
   
  
• ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture.
  Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y, Otonkoski T
  Endocrinology. 2002
  PubMed ID: 12399441
   
  
• Pax-2 activates the proglucagon gene promoter but is not essential for proglucagon gene expression or development of proglucagon-producing cell lineages in the murine pancreas or intestine.
  Flock G, Drucker DJ
  Mol Endocrinol. 2002
  PubMed ID: 12351699
   
  
• Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance.
  Kido Y, Nakae J, Hribal ML, Xuan S, Efstratiadis A, Accili D
  J Biol Chem. 2002
  PubMed ID: 12101187
   
  
• Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism.
  Light PE, Manning Fox JE, Riedel MJ, Wheeler MB
  Mol Endocrinol. 2002
  PubMed ID: 12198249
   
  
• Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression.
  Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJ
  Biochem J. 2002
  PubMed ID: 12000309
   
  
• Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
  Zhu X, Zhou A, Dey A, Norrbom C, Carroll R, Zhang C, Laurent V, Lindberg I, Ugleholdt R, Holst JJ, Steiner DF
  Proc Natl Acad Sci U S A. 2002
  PubMed ID: 12145326
   
  
• Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.
  Nammo T, Yamagata K, Hamaoka R, Zhu Q, Akiyama TE, Gonzalez FJ, Miyagawa J, Matsuzawa Y
  Diabetologia. 2002
  PubMed ID: 12189445
   
  
• Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
  Wilson ME, Kalamaras JA, German MS
  Mech Dev. 2002
  PubMed ID: 12049785
   
  
• Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.
  Hussain MA, Miller CP, Habener JF
  J Biol Chem. 2002
  PubMed ID: 11834725
   
  
• Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus.
  Kim SK, Selleri L, Lee JS, Zhang AY, Gu X, Jacobs Y, Cleary ML
  Nat Genet. 2002
  PubMed ID: 11912494
   
  
• Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.
  Duvillié B, Currie C, Chrones T, Bucchini D, Jami J, Joshi RL, Hill DJ
  Endocrinology. 2002
  PubMed ID: 11897712
   
  
• Persistent expression of Hlxb9 in the pancreatic epithelium impairs pancreatic development.
  Li H, Edlund H
  Dev Biol. 2001
  PubMed ID: 11784060
   
  
• The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.
  Allen-Jennings AE, Hartman MG, Kociba GJ, Hai T
  J Biol Chem. 2001
  PubMed ID: 11371557
   
  
• Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice.
  Furuta M, Zhou A, Webb G, Carroll R, Ravazzola M, Orci L, Steiner DF
  J Biol Chem. 2001
  PubMed ID: 11356850
   
  
• Translational control is required for the unfolded protein response and in vivo glucose homeostasis.
  Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ
  Mol Cell. 2001
  PubMed ID: 11430820
   
  
• Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
  Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M
  Development. 2000
  PubMed ID: 11076772
   
  
• Regulation of pancreas development by hedgehog signaling.
  Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA
  Development. 2000
  PubMed ID: 11044404
   
  
• Glucagon receptors on human islet cells contribute to glucose competence of insulin release.
  Huypens P, Ling Z, Pipeleers D, Schuit F
  Diabetologia. 2000
  PubMed ID: 10990079
   
  
• Activin receptor patterning of foregut organogenesis.
  Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA
  Genes Dev. 2000
  PubMed ID: 10921901
   
  
• Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
  Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS
  Development. 2000
  PubMed ID: 10903178
   
  
• Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function.
  Gannon M, Ray MK, Van Zee K, Rausa F, Costa RH, Wright CV
  Development. 2000
  PubMed ID: 10851133
   
  
• Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.
  Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP
  Mol Cell Biol. 2000
  PubMed ID: 10825208
   
  
• Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors.
  Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilainen S, Lehtonen E, Keski-Oja J, Otonkoski T
  Development. 2000
  PubMed ID: 10821760
   
  
• Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: implications for lineage selection.
  Maldonado TS, Kadison AS, Crisera CA, Grau JB, Alkasab SL, Longaker MT, Gittes GK
  J Gastrointest Surg. 2000
  PubMed ID: 10769089
   
  
• neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas.
  Gradwohl G, Dierich A, LeMeur M, Guillemot F
  Proc Natl Acad Sci U S A. 2000
  PubMed ID: 10677506
   
  
• Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.
  Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P
  Diabetes. 2000
  PubMed ID: 10868931
   
  
• Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.
  Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH
  Nat Genet. 1999
  PubMed ID: 10471502
   
  
• Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9.
  Li H, Arber S, Jessell TM, Edlund H
  Nat Genet. 1999
  PubMed ID: 10471501
   
  
• Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.
  Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF
  Nat Genet. 1999
  PubMed ID: 10471495
   
  
• Differential mRNA display analysis of two related but functionally distinct rat insulinoma (RIN) cell lines: identification of CD24 and its expression in the developing pancreas.
  Cram DS, McIntosh A, Oxbrow L, Johnston AM, DeAizpurua HJ
  Differentiation. 1999
  PubMed ID: 10365441
   
  
• Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells.
  Jiang FX, Cram DS, DeAizpurua HJ, Harrison LC
  Diabetes. 1999
  PubMed ID: 10102687
   
  
• Molecular cloning of a pancreatic islet-specific glucose-6-phosphatase catalytic subunit-related protein.
  Arden SD, Zahn T, Steegers S, Webb S, Bergman B, O'Brien RM, Hutton JC
  Diabetes. 1999
  PubMed ID: 10078553
   
  
• Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo.
  Kaestner KH, Katz J, Liu Y, Drucker DJ, Schütz G
  Genes Dev. 1999
  PubMed ID: 10049364
   
  
• Neural cell adhesion molecule (N-CAM) is required for cell type segregation and normal ultrastructure in pancreatic islets.
  Esni F, Täljedal IB, Perl AK, Cremer H, Christofori G, Semb H
  J Cell Biol. 1999
  PubMed ID: 9922458
   
  
• Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.
  Seufert J, Kieffer TJ, Habener JF
  Proc Natl Acad Sci U S A. 1999
  PubMed ID: 9892692
   
  
• Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin.
  Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P
  Dev Genet. 1999
  PubMed ID: 10079507
   
  
• The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.
  Krapp A, Knöfler M, Ledermann B, Bürki K, Berney C, Zoerkler N, Hagenbüchle O, Wellauer PK
  Genes Dev. 1998
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• Histidine availability alters glucagon gene expression in murine alphaTC6 cells.
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• Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
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  Development. 1998
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• Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
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  Genes Dev. 1997
  PubMed ID: 9224716
   
  
• The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas.
  Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P
  Nature. 1997
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• Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells.
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• Cadherins regulate aggregation of pancreatic beta-cells in vivo.
  Dahl U, Sjødin A, Semb H
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• Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line.
  Lü F, Jin T, Drucker DJ
  Endocrinology. 1996
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• PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells.
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• The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice.
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• Developmental biology of the pancreas.
  Slack JM
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• Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny.
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Publications: 271

• Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.
  Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV
  Genes Dev. 2011
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• Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.
  Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, Barzilai N, Oren R, Fishman S
  J Hepatol. 2011
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• Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling.
  Miller LJ, Chen Q, Lam PC, Pinon DI, Sexton PM, Abagyan R, Dong M
  J Biol Chem. 2011
  PubMed ID: 21454562
   
  
• Glucagon-like peptide 1 and the brain: central actions-central sources?
  Trapp S, Hisadome K
  Auton Neurosci. 2011
  PubMed ID: 20951098
   
  
• Growth-limiting role of endothelial cells in endoderm development.
  Sand FW, Hörnblad A, Johansson JK, Lorén C, Edsbagge J, Ståhlberg A, Magenheim J, Ilovich O, Mishani E, Dor Y, Ahlgren U, Semb H
  Dev Biol. 2011
  PubMed ID: 21281624
   
  
• Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway.
  Shi X, Li X, Wang Y, Zhang K, Zhou F, Chan L, Li D, Guan X
  Am J Physiol Endocrinol Metab. 2011
  PubMed ID: 21177288
   
  
• A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1.
  Patterson JT, Ottaway N, Gelfanov VM, Smiley DL, Perez-Tilve D, Pfluger PT, Tschöp MH, Dimarchi RD
  ACS Chem Biol. 2011
  PubMed ID: 20939591
   
  
• ANTIAPOPTOTIC EFFECTS OF GLP-1 IN MURINE HL-1 CARDIOMYOCYTES.
  Ravassa S, Zudaire A, Carr RD, Diez J
  Am J Physiol Heart Circ Physiol. 2011
  PubMed ID: 21278133
   
  
• Conformational and molecular interaction studies of glucagon-like peptide-2 with its N-terminal extracellular receptor domain.
  Venneti KC, Hewage CM
  FEBS Lett. 2011
  PubMed ID: 21167157
   
  
• Insulin and glucagon regulate pancreatic α-cell proliferation.
  Liu Z, Kim W, Chen Z, Shin YK, Carlson OD, Fiori JL, Xin L, Napora JK, Short R, Odetunde JO, Lao Q, Egan JM
  PLoS One. 2011
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• A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
  Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
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• Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.
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• Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?
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• GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.
  Griffioen KJ, Wan R, Okun E, Wang X, Lovett-Barr MR, Li Y, Mughal MR, Mendelowitz D, Mattson MP
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• Role of glucocorticoids in tuning hindbrain stress integration.
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• Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate.
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• Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program.
  Jablonski KA, McAteer JB, de Bakker PI, Franks PW, Pollin TI, Hanson RL, Saxena R, Fowler S, Shuldiner AR, Knowler WC, Altshuler D, Florez JC, Diabetes Prevention Program Research Group
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• Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
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• Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus.
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• Generation of mice with a conditional null allele for Wntless.
  Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA
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• Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.
  Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira S, Aoki J, Arai H, Yamaguchi T, Itabe H
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• Impaired pancreatic development in Hif2-alpha deficient mice.
  Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F
  Biochem Biophys Res Commun. 2010
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• Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats.
  Yoder SM, Yang Q, Kindel TL, Tso P
  Am J Physiol Gastrointest Liver Physiol. 2010
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• Glucagon-like peptide 1 prevents reactive oxygen species-induced endothelial cell senescence through the activation of protein kinase A.
  Oeseburg H, de Boer RA, Buikema H, van der Harst P, van Gilst WH, Silljé HH
  Arterioscler Thromb Vasc Biol. 2010
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• Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice.
  Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM
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• Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival.
  Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, Gradwohl G
  J Clin Invest. 2010
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• Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of ß-cell regeneration.
  Kilimnik G, Kim A, Steiner DF, Friedman TC, Hara M
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• The role of maternal gut hormones in normal pregnancy: fasting plasma active glucagon-like peptide 1 level is a negative predictor of fetal abdomen circumference and maternal weight change.
  Valsamakis G, Margeli A, Vitoratos N, Boutsiadis A, Sakkas EG, Papadimitriou G, Al-Daghri NM, Botsis D, Kumar S, Papassotiriou I, Creatsas G, Mastorakos G
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• [Expression of glucagon in gestational and diet-induced hyperlipidemic gestational rats]
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• Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor.
  Ban K, Kim KH, Cho CK, Sauvé M, Diamandis EP, Backx PH, Drucker DJ, Husain M
  Endocrinology. 2010
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• Amelioration of hyperglycemia by intestinal overexpression of glucagon-like peptide-1 in mice.
  Liu MJ, Han J, Lee YS, Park MS, Shin S, Jun HS
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• Neonatal intramuscular injection of plasmid encoding glucagon-like peptide-1 affects anxiety behaviour and expression of the hippocampal glucocorticoid receptor in adolescent rats.
  Fan H, Wang L, Guo F, Wei S, Zhao R
  J Biosci. 2010
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• The quantity of meal fat influences the profile of postprandial hormones as well as hunger sensation in healthy elderly people.
  Di Francesco V, Barazzoni R, Bissoli L, Fantin F, Rizzotti P, Residori L, Antonioli A, Graziani MS, Zanetti M, Bosello O, Guarnieri G, Zamboni M
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• Signaling and biological effects of glucagon-like peptide 1 on the differentiation of mesenchymal stem cells from human bone marrow.
  Sanz C, Vázquez P, Blázquez C, Barrio PA, Alvarez Mdel M, Blázquez E
  Am J Physiol Endocrinol Metab. 2010
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• Expecting to eat: glucagon-like peptide-1 and the anticipation of meals.
  Williams DL
  Endocrinology. 2010
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• Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men.
  Carr RD, Larsen MO, Jelic K, Lindgren O, Vikman J, Holst JJ, Deacon CF, Ahrén B
  J Clin Endocrinol Metab. 2010
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• Reduced plasma levels of glucagon-like peptide-1 in elderly men are associated with impaired glucose tolerance but not with coronary heart disease.
  Nathanson D, Zethelius B, Berne C, Holst JJ, Sjöholm A, Nyström T
  Diabetologia. 2010
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• Meal-anticipatory glucagon-like peptide-1 secretion in rats.
  Vahl TP, Drazen DL, Seeley RJ, D'Alessio DA, Woods SC
  Endocrinology. 2010
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• Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion.
  Beglinger S, Drewe J, Schirra J, Göke B, D'Amato M, Beglinger C
  J Clin Endocrinol Metab. 2010
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• Elevated circulating levels of an incretin hormone, glucagon-like peptide-1, are associated with metabolic components in high-risk patients with cardiovascular disease.
  Yamaoka-Tojo M, Tojo T, Takahira N, Matsunaga A, Aoyama N, Masuda T, Izumi T
  Cardiovasc Diabetol. 2010
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• Increased postprandial response of glucagon-like peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency.
  Hornum M, Pedersen JF, Larsen S, Olsen O, Holst JJ, Knop FK
  Pancreatology. 2010
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• Role of glucagon-like peptide- 1 in vascular endothelial dysfunction.
  Goyal S, Kumar S, Bijjem KV, Singh M
  Indian J Exp Biol. 2010
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• Neonatal intramuscular injection of plasmid DNA encoding GLP-1 reduces serum insulin level and modifies skeletal muscle myosin heavy chain composition in adult rats.
  Wang L, Guo F, Wei S, Zhao R
  Physiol Res. 2010
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• Intact glucagon-like peptide-1 levels are not decreased in Japanese patients with type 2 diabetes.
  Lee S, Yabe D, Nohtomi K, Takada M, Morita R, Seino Y, Hirano T
  Endocr J. 2010
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• Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects.
  Freeland KR, Wilson C, Wolever TM
  Br J Nutr. 2010
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• Integrative predictive model of coronary artery calcification in atherosclerosis.
  McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF
  Circulation. 2009
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• The rho guanosine 5'-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucagon-like peptide-1 secretion in the intestinal endocrine L cell.
  Lim GE, Xu M, Sun J, Jin T, Brubaker PL
  Endocrinology. 2009
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• Ingestion of diet soda before a glucose load augments glucagon-like peptide-1 secretion.
  Brown RJ, Walter M, Rother KI
  Diabetes Care. 2009
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• Comparable effects of moderate intensity exercise on changes in anorectic gut hormone levels and energy intake to high intensity exercise.
  Ueda SY, Yoshikawa T, Katsura Y, Usui T, Fujimoto S
  J Endocrinol. 2009
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• Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons.
  Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM
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• Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery.
  Onoue S, Yamamoto K, Kawabata Y, Hirose M, Mizumoto T, Yamada S
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• Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways.
  Iwai T, Hayashi Y, Narita S, Kasuya Y, Jin K, Tsugane M, Oka J
  Behav Brain Res. 2009
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• Cdc42-mediated tubulogenesis controls cell specification.
  Kesavan G, Sand FW, Greiner TU, Johansson JK, Kobberup S, Wu X, Brakebusch C, Semb H
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• Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
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• GLP-1 secretion is enhanced directly in the ileum but indirectly in the duodenum by a newly identified potent stimulator, zein hydrolysate, in rats.
  Hira T, Mochida T, Miyashita K, Hara H
  Am J Physiol Gastrointest Liver Physiol. 2009
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• Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation.
  Dozier KC, Cureton EL, Kwan RO, Curran B, Sadjadi J, Victorino GP
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• Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women.
  Brennan IM, Feltrin KL, Nair NS, Hausken T, Little TJ, Gentilcore D, Wishart JM, Jones KL, Horowitz M, Feinle-Bisset C
  Am J Physiol Gastrointest Liver Physiol. 2009
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• Glucagon-like peptide-1 secretion in bulimia nervosa.
  Brambilla F, Monteleone P, Maj M
  Psychiatry Res. 2009
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• Stimulation of incretin secretion by dietary lipid: is it dose dependent?
  Yoder SM, Yang Q, Kindel TL, Tso P
  Am J Physiol Gastrointest Liver Physiol. 2009
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• Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.
  Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH
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• The relationship between glucagon-like peptide 2 and feeding intolerance in preterm infants.
  Ozer EA, Holst JJ, Duman N, Kumral A, Ozkan H
  J Trop Pediatr. 2009
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• Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.
  Matsui K, Oda T, Nishizawa E, Sano R, Yamamoto H, Fukuda S, Sasase T, Miyajima K, Ueda N, Ishii Y, Ohta T, Matsushita M
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• Sox17 regulates organ lineage segregation of ventral foregut progenitor cells.
  Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM
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• The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.
  Jacobo SM, Guerra ML, Jarrard RE, Przybyla JA, Liu G, Watts VJ, Hockerman GH
  J Pharmacol Exp Ther. 2009
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• The effects of two different hypocaloric diets on glucagon-like peptide 1 in obese adults, relation with insulin response after weight loss.
  de Luis DA, Sagrado MG, Conde R, Aller R, Izaola O
  J Diabetes Complications. 2009
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• An appraisal of intermediate filament expression in adult and developing pancreas: vimentin is expressed in alpha cells of rat and mouse embryos.
  Di Bella A, Regoli M, Nicoletti C, Ermini L, Fonzi L, Bertelli E
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• Lineage-specific biology revealed by a finished genome assembly of the mouse.
  Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
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• Circadian rhythms of GIP and GLP1 in glucose-tolerant and in type 2 diabetic patients after biliopancreatic diversion.
  Mingrone G, Nolfe G, Gissey GC, Iaconelli A, Leccesi L, Guidone C, Nanni G, Holst JJ
  Diabetologia. 2009
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• Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress.
  Zhang R, Packard BA, Tauchi M, D'Alessio DA, Herman JP
  Proc Natl Acad Sci U S A. 2009
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• MFng is dispensable for mouse pancreas development and function.
  Svensson P, Bergqvist I, Norlin S, Edlund H
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• Glucagon-like peptide-2 relaxes mouse stomach through vasoactive intestinal peptide release.
  Amato A, Baldassano S, Serio R, Mulè F
  Am J Physiol Gastrointest Liver Physiol. 2009
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• Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
  Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK
  Endocr Relat Cancer. 2009
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• Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.
  Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S
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• Amyloidogenicity and aggregate cytotoxicity of human glucagon-like peptide-1 (hGLP-1).
  Poon S, Birkett NR, Fowler SB, Luisi BF, Dobson CM, Zurdo J
  Protein Pept Lett. 2009
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• Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.
  Chung WK, Patki A, Matsuoka N, Boyer BB, Liu N, Musani SK, Goropashnaya AV, Tan PL, Katsanis N, Johnson SB, Gregersen PK, Allison DB, Leibel RL, Tiwari HK
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• Aquaporin 2 expression increased by glucagon in normal rat inner medullary collecting ducts.
  Yano Y, Cesar KR, Araujo M, Rodrigues AC, Andrade LC, Magaldi AJ
  Am J Physiol Renal Physiol. 2009
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• Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2.
  Ivory CP, Wallace LE, McCafferty DM, Sigalet DL
  Am J Physiol Gastrointest Liver Physiol. 2008
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• Enteral nutrients potentiate the intestinotrophic action of glucagon-like peptide-2 in association with increased insulin-like growth factor-I responses in rats.
  Liu X, Murali SG, Holst JJ, Ney DM
  Am J Physiol Regul Integr Comp Physiol. 2008
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• Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42).
  Qin Z, Sun Z, Huang J, Hu Y, Wu Z, Mei B
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• Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure.
  Knauf C, Cani PD, Ait-Belgnaoui A, Benani A, Dray C, Cabou C, Colom A, Uldry M, Rastrelli S, Sabatier E, Godet N, Waget A, Pénicaud L, Valet P, Burcelin R
  Endocrinology. 2008
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• Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans.
  Bharucha AE, Charkoudian N, Andrews CN, Camilleri M, Sletten D, Zinsmeister AR, Low PA
  Am J Physiol Regul Integr Comp Physiol. 2008
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• Appetite-related gut peptides, ghrelin, PYY, and GLP-1 in obese women with and without binge eating disorder (BED).
  Geliebter A, Hashim SA, Gluck ME
  Physiol Behav. 2008
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• Measuring the effect of a study meal on portal concentrations of glucagon-like peptide 1 (GLP-1) in non diabetic and diabetic patients with liver cirrhosis: transjugular intrahepatic portosystemic stent shunt (TIPSS) as a new method for metabolic measurem
  Raddatz D, Nolte W, Rossbach C, Leonhardt U, Buchwald A, Scholz KH, Ramadori G
  Exp Clin Endocrinol Diabetes. 2008
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• Characteristics of GLP-1 and exendins action upon glucose transport and metabolism in type 2 diabetic rat skeletal muscle.
  Arnés L, González N, Tornero-Esteban P, Sancho V, Acitores A, Valverde I, Delgado E, Villanueva-Peñacarrillo ML
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• Expression patterns of epiplakin1 in pancreas, pancreatic cancer and regenerating pancreas.
  Yoshida T, Shiraki N, Baba H, Goto M, Fujiwara S, Kume K, Kume S
  Genes Cells. 2008
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• Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP.
  Harney JA, Rodgers RL
  Am J Physiol Endocrinol Metab. 2008
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• Modulation of taste sensitivity by GLP-1 signaling.
  Shin YK, Martin B, Golden E, Dotson CD, Maudsley S, Kim W, Jang HJ, Mattson MP, Drucker DJ, Egan JM, Munger SD
  J Neurochem. 2008
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• Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
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  Mol Biotechnol. 2008
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• GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome.
  Hellström PM, Näslund E, Edholm T, Schmidt PT, Kristensen J, Theodorsson E, Holst JJ, Efendic S
  Neurogastroenterol Motil. 2008
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• Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study.
  Laakso M, Zilinskaite J, Hansen T, Boesgaard TW, Vänttinen M, Stancáková A, Jansson PA, Pellmé F, Holst JJ, Kuulasmaa T, Hribal ML, Sesti G, Stefan N, Fritsche A, Häring H, Pedersen O, Smith U, EUGENE2 Consortium
  Diabetologia. 2008
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• Altered expression of glucagon-like peptide-1 and dipeptidyl peptidase IV in patients with HCV-related glucose intolerance.
  Itou M, Kawaguchi T, Taniguchi E, Sumie S, Oriishi T, Mitsuyama K, Tsuruta O, Ueno T, Sata M
  J Gastroenterol Hepatol. 2008
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• Dissociation of heterotrimeric g proteins in cells.
  Lambert NA
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• Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.
  Lynn FC, Sanchez L, Gomis R, German MS, Gasa R
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• GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise.
  Chanoine JP, Mackelvie KJ, Barr SI, Wong AC, Meneilly GS, Elahi DH
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• Glucagon-like peptide-1 attenuates tumour necrosis factor-alpha-mediated induction of plasmogen activator inhibitor-1 expression.
  Liu H, Hu Y, Simpson RW, Dear AE
  J Endocrinol. 2008
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• Mash1 is required for neuroendocrine cell development in the glandular stomach.
  Kokubu H, Ohtsuka T, Kageyama R
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• Expression of glucagon-like peptide-1 in the taste buds of rat circumvallate papillae.
  Feng XH, Liu XM, Zhou LH, Wang J, Liu GD
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• Influence of BMI and gender on postprandial hormone responses.
  Carroll JF, Kaiser KA, Franks SF, Deere C, Caffrey JL
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• Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
  Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, Bernier M, Mosinger B, Margolskee RF, Egan JM
  Proc Natl Acad Sci U S A. 2007
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• Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate.
  López-Díaz L, Jain RN, Keeley TM, VanDussen KL, Brunkan CS, Gumucio DL, Samuelson LC
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• Recovery from diabetes in mice by beta cell regeneration.
  Nir T, Melton DA, Dor Y
  J Clin Invest. 2007
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• Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans.
  Meier JJ, Holst JJ, Schmidt WE, Nauck MA
  Am J Physiol Endocrinol Metab. 2007
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• GLP-1 amplifies insulin signaling by up-regulation of IRbeta, IRS-1 and Glut4 in 3T3-L1 adipocytes.
  Gao H, Wang X, Zhang Z, Yang Y, Yang J, Li X, Ning G
  Endocrine. 2007
  PubMed ID: 17992607
   
  
• Role of glial cell-line derived neurotropic factor family receptor alpha2 in the actions of the glucagon-like peptides on the murine intestine.
  McDonagh SC, Lee J, Izzo A, Brubaker PL
  Am J Physiol Gastrointest Liver Physiol. 2007
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• Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons.
  Ma X, Bruning J, Ashcroft FM
  J Neurosci. 2007
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• Safety and adverse effects associated with GLP-1 analogues.
  Stephens JW, Bain SC
  Expert Opin Drug Saf. 2007
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• Sox9 coordinates a transcriptional network in pancreatic progenitor cells.
  Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17563382
   
  
• Glucagon-like peptide-1 accelerates the onset of insulin action on glucose disappearance in mice.
  Thomaseth K, Pavan A, Pacini G, Ahrén B
  Am J Physiol Endocrinol Metab. 2007
  PubMed ID: 17311896
   
  
• Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation.
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  Dev Biol. 2007
  PubMed ID: 17400205
   
  
• Nitrergic contribution to gastric relaxation induced by glucagon-like peptide-1 (GLP-1) in healthy adults.
  Andrews CN, Bharucha AE, Camilleri M, Low PA, Seide B, Burton D, Baxter K, Zinsmeister AR
  Am J Physiol Gastrointest Liver Physiol. 2007
  PubMed ID: 17290009
   
  
• FGF10 signaling controls stomach morphogenesis.
  Nyeng P, Norgaard GA, Kobberup S, Jensen J
  Dev Biol. 2007
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• SOX9 is required for maintenance of the pancreatic progenitor cell pool.
  Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M
  Proc Natl Acad Sci U S A. 2007
  PubMed ID: 17267606
   
  
• Absolute correlation between lag time and growth rate in the spontaneous formation of several amyloid-like aggregates and fibrils.
  Fändrich M
  J Mol Biol. 2007
  PubMed ID: 17141269
   
  
• Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia.
  Porcellati F, Pampanelli S, Rossetti P, Busciantella Ricci N, Marzotti S, Lucidi P, Santeusanio F, Bolli GB, Fanelli CG
  Diabetologia. 2007
  PubMed ID: 17160672
   
  
• WT1-mediated gene regulation in early urogenital ridge development.
  Klattig J, Sierig R, Kruspe D, Makki MS, Englert C
  Sex Dev. 2007
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• Glucagon-like peptide-2 in umbilical cord blood from mature infants.
  Bodé S, Hartmann B, Holst JJ, Greisen G
  Neonatology. 2007
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• Origin and characteristics of glycogen cells in the developing murine placenta.
  Coan PM, Conroy N, Burton GJ, Ferguson-Smith AC
  Dev Dyn. 2006
  PubMed ID: 17039549
   
  
• Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY?
  Beglinger C, Degen L
  Physiol Behav. 2006
  PubMed ID: 16828127
   
  
• Glucagon suppression of ghrelin secretion is exerted at hypothalamus-pituitary level.
  Arafat AM, Perschel FH, Otto B, Weickert MO, Rochlitz H, Schöfl C, Spranger J, Möhlig M, Pfeiffer AF
  J Clin Endocrinol Metab. 2006
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• Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
  Dowal L, Provitera P, Scarlata S
  J Biol Chem. 2006
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• Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice.
  Asayesh A, Sharpe J, Watson RP, Hecksher-Sørensen J, Hastie ND, Hill RE, Ahlgren U
  Genes Dev. 2006
  PubMed ID: 16912273
   
  
• The normal phenotype of Pmm1-deficient mice suggests that Pmm1 is not essential for normal mouse development.
  Cromphout K, Vleugels W, Heykants L, Schollen E, Keldermans L, Sciot R, D'Hooge R, De Deyn PP, von Figura K, Hartmann D, Körner C, Matthijs G
  Mol Cell Biol. 2006
  PubMed ID: 16847318
   
  
• Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.
  Lotfi S, Li Z, Sun J, Zuo Y, Lam PP, Kang Y, Rahimi M, Islam D, Wang P, Gaisano HY, Jin T
  Endocrinology. 2006
  PubMed ID: 16644915
   
  
• Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men.
  Feltrin KL, Patterson M, Ghatei MA, Bloom SR, Meyer JH, Horowitz M, Feinle-Bisset C
  Peptides. 2006
  PubMed ID: 16563563
   
  
• Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.
  Kilic G, Wang J, Sosa-Pineda B
  Dev Dyn. 2006
  PubMed ID: 16518820
   
  
• Chromosome 2 locus Nidd5 has a potent effect on adiposity in the TSOD mouse.
  Mizutani S, Gomi H, Hirayama I, Izumi T
  Mamm Genome. 2006
  PubMed ID: 16688528
   
  
• Stabilization of beta-catenin impacts pancreas growth.
  Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M
  Development. 2006
  PubMed ID: 16611688
   
  
• BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
  Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T
  PLoS Biol. 2006
  PubMed ID: 16602821
   
  
• Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin.
  Adachi T, Tanaka T, Takemoto K, Koshimizu TA, Hirasawa A, Tsujimoto G
  Biochem Biophys Res Commun. 2006
  PubMed ID: 16356474
   
  
• Glucagon-like peptide 2 stimulates glucagon secretion, enhances lipid absorption, and inhibits gastric acid secretion in humans.
  Meier JJ, Nauck MA, Pott A, Heinze K, Goetze O, Bulut K, Schmidt WE, Gallwitz B, Holst JJ
  Gastroenterology. 2006
  PubMed ID: 16401467
   
  
• Glucagon secretion in relation to insulin sensitivity in healthy subjects.
  Ahrén B
  Diabetologia. 2006
  PubMed ID: 16362283
   
  
• Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development.
  Alanentalo T, Chatonnet F, Karlen M, Sulniute R, Ericson J, Andersson E, Ahlgren U
  Gene Expr Patterns. 2006
  PubMed ID: 16326147
   
  
• Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.
  Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R
  J Clin Invest. 2005
  PubMed ID: 16322793
   
  
• Antisense transcription in the mammalian transcriptome.
  Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
  Science. 2005
  PubMed ID: 16141073
   
  
• The transcriptional landscape of the mammalian genome.
  Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
  Science. 2005
  PubMed ID: 16141072
   
  
• Role of recombinant human glicentin in the normal human jejunum: an in vitro study.
  Tomita R, Igarashi S, Tanjoh K, Fujisaki S
  Hepatogastroenterology. 2005
  PubMed ID: 16201096
   
  
• Alpha cell function in health and disease: influence of glucagon-like peptide-1.
  Dunning BE, Foley JE, Ahrén B
  Diabetologia. 2005
  PubMed ID: 16132964
   
  
• Glucagon inhibits ghrelin secretion in humans.
  Arafat MA, Otto B, Rochlitz H, Tschöp M, Bähr V, Möhlig M, Diederich S, Spranger J, Pfeiffer AF
  Eur J Endocrinol. 2005
  PubMed ID: 16131602
   
  
• Impact of glucagon response on postprandial hyperglycemia in men with impaired glucose tolerance and type 2 diabetes mellitus.
  Henkel E, Menschikowski M, Koehler C, Leonhardt W, Hanefeld M
  Metabolism. 2005
  PubMed ID: 16125528
   
  
• Direct regulation of intestinal fate by Notch.
  Stanger BZ, Datar R, Murtaugh LC, Melton DA
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 16107537
   
  
• Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice.
  Martín M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dollé P, Gradwohl G
  Dev Biol. 2005
  PubMed ID: 16026781
   
  
• Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects.
  Meier JJ, Kemmeries G, Holst JJ, Nauck MA
  Diabetes. 2005
  PubMed ID: 15983224
   
  
• Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes.
  Gautier JF, Fetita S, Sobngwi E, Salaün-Martin C
  Diabetes Metab. 2005
  PubMed ID: 16142014
   
  
• Transiently truncated and differentially regulated expression of midkine during mouse embryogenesis.
  Chen Q, Yuan Y, Lin S, Chang Y, Zhuo X, Wei W, Tao P, Ruan L, Li Q, Li Z
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15823575
   
  
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
  Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK
  Nature. 2005
  PubMed ID: 15815621
   
  
• Decreased glucagon-like peptide 1 release after weight loss in overweight/obese subjects.
  Adam TC, Jocken J, Westerterp-Plantenga MS
  Obes Res. 2005
  PubMed ID: 15897480
   
  
• Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.
  Katsuma S, Hirasawa A, Tsujimoto G
  Biochem Biophys Res Commun. 2005
  PubMed ID: 15721318
   
  
• Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
  González N, Acitores A, Sancho V, Valverde I, Villanueva-Peñacarrillo ML
  Regul Pept. 2005
  PubMed ID: 15664668
   
  
• Lack of TCF2/vHNF1 in mice leads to pancreas agenesis.
  Haumaitre C, Barbacci E, Jenny M, Ott MO, Gradwohl G, Cereghini S
  Proc Natl Acad Sci U S A. 2005
  PubMed ID: 15668393
   
  
• Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.
  Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM
  Diabetes. 2005
  PubMed ID: 15616022
   
  
• The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.
  Lachey JL, D'Alessio DA, Rinaman L, Elmquist JK, Drucker DJ, Seeley RJ
  Endocrinology. 2005
  PubMed ID: 15459118
   
  
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
  Genome Res. 2004
  PubMed ID: 15489334
   
  
• Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal.
  Acuna-Goycolea C, van den Pol A
  J Neurosci. 2004
  PubMed ID: 15371515
   
  
• Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.
  Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM
  Diabetologia. 2004
  PubMed ID: 15365617
   
  
• Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
  Baggio LL, Huang Q, Brown TJ, Drucker DJ
  Gastroenterology. 2004
  PubMed ID: 15300587
   
  
• Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach.
  Lippl F, Kircher F, Erdmann J, Allescher HD, Schusdziarra V
  Regul Pept. 2004
  PubMed ID: 15093702
   
  
• Orlistat augments postprandial increases in glucagon-like peptide 1 in obese type 2 diabetic patients.
  Damci T, Yalin S, Balci H, Osar Z, Korugan U, Ozyazar M, Ilkova H
  Diabetes Care. 2004
  PubMed ID: 15111524
   
  
• High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
  Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
  Genome Res. 2004
  PubMed ID: 15060019
   
  
• The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.
  Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB, Madsen OD, Serup P
  Dev Biol. 2004
  PubMed ID: 15031110
   
  
• Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
  Meier JJ, Nauck MA, Kranz D, Holst JJ, Deacon CF, Gaeckler D, Schmidt WE, Gallwitz B
  Diabetes. 2004
  PubMed ID: 14988249
   
  
• Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis.
  Ishikawa A, Namikawa T
  Genes Genet Syst. 2004
  PubMed ID: 15056934
   
  
• Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion.
  Lugari R, Dei Cas A, Ugolotti D, Barilli AL, Camellini C, Ganzerla GC, Luciani A, Salerni B, Mittenperger F, Nodari S, Gnudi A, Zandomeneghi R
  Horm Metab Res. 2004
  PubMed ID: 15002062
   
  
• Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.
  Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS
  Development. 2004
  PubMed ID: 14736744
   
  
• Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.
  Yoshitomi H, Zaret KS
  Development. 2004
  PubMed ID: 14736742
   
  
• Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas.
  Esni F, Stoffers DA, Takeuchi T, Leach SD
  Mech Dev. 2004
  PubMed ID: 14706696
   
  
• FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development.
  Norgaard GA, Jensen JN, Jensen J
  Dev Biol. 2003
  PubMed ID: 14651921
   
  
• Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.
  Brubaker PL, Anini Y
  Can J Physiol Pharmacol. 2003
  PubMed ID: 14719035
   
  
• Clinical significance of GLP-2 in short-bowel syndrome.
  Jeppesen PB
  J Nutr. 2003
  PubMed ID: 14608103
   
  
• Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants.
  Tadokoro R, Shimizu T, Hosaka A, Kaneko N, Satoh Y, Yamashiro Y
  Acta Paediatr. 2003
  PubMed ID: 14632334
   
  
• Oxyntomodulin suppresses appetite and reduces food intake in humans.
  Cohen MA, Ellis SM, Le Roux CW, Batterham RL, Park A, Patterson M, Frost GS, Ghatei MA, Bloom SR
  J Clin Endocrinol Metab. 2003
  PubMed ID: 14557443
   
  
• Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine.
  Johnston KL, Clifford MN, Morgan LM
  Am J Clin Nutr. 2003
  PubMed ID: 14522730
   
  
• Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
  Hart A, Papadopoulou S, Edlund H
  Dev Dyn. 2003
  PubMed ID: 14517990
   
  
• Glucagon-like peptide-2 receptor activation in the rat intestinal mucosa.
  Walsh NA, Yusta B, DaCambra MP, Anini Y, Drucker DJ, Brubaker PL
  Endocrinology. 2003
  PubMed ID: 12960094
   
  
• Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1 (GLP-1) in healthy volunteers.
  Meier S, Hücking K, Ritzel R, Holst JJ, Schmiegel WH, Nauck MA
  Horm Metab Res. 2003
  PubMed ID: 14517773
   
  
• The daily rhythm in plasma glucagon concentrations in the rat is modulated by the biological clock and by feeding behavior.
  Ruiter M, La Fleur SE, van Heijningen C, van der Vliet J, Kalsbeek A, Buijs RM
  Diabetes. 2003
  PubMed ID: 12829637
   
  
• Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.
  Anini Y, Brubaker PL
  Endocrinology. 2003
  PubMed ID: 12810581
   
  
• Cell signalling of the GLP-1 action in rat liver.
  Redondo A, Trigo MV, Acitores A, Valverde I, Villanueva-Peñacarrillo ML
  Mol Cell Endocrinol. 2003
  PubMed ID: 12850280
   
  
• Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas.
  Jiang Y, Liu MT, Gershon MD
  Dev Biol. 2003
  PubMed ID: 12798294
   
  
• Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes.
  Gradilone SA, García F, Huebert RC, Tietz PS, Larocca MC, Kierbel A, Carreras FI, Larusso NF, Marinelli RA
  Hepatology. 2003
  PubMed ID: 12774023
   
  
• Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy.
  Cameron HL, Yang PC, Perdue MH
  Am J Physiol Gastrointest Liver Physiol. 2003
  PubMed ID: 12736145
   
  
• Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells.
  Suzuki A, Nakauchi H, Taniguchi H
  Proc Natl Acad Sci U S A. 2003
  PubMed ID: 12702762
   
  
• Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine.
  Okada S, Misaka T, Matsumoto I, Watanabe H, Abe K
  FEBS Lett. 2003
  PubMed ID: 12681500
   
  
• Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas.
  Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P
  Dev Dyn. 2003
  PubMed ID: 12666204
   
  
• Insulin and glucagon regulation of glutathione S-transferase expression in primary cultured rat hepatocytes.
  Kim SK, Woodcroft KJ, Novak RF
  J Pharmacol Exp Ther. 2003
  PubMed ID: 12649389
   
  
• Glucagon and regulation of glucose metabolism.
  Jiang G, Zhang BB
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