GATA4

Summary Top Help

Gene Description:

GATA binding protein 4

Synonyms:

ASD2, GATA4, VSD1, Gata-4, Gata4

Orthologs:

Human GATA4 (protein-coding), Mouse Gata4 (protein-coding), Rat Gata4 (protein-coding)

Sources

Gene Overview from Genome Browser Top Help

(Human) GRCh37 - chr8:11534468..11617511 (834 kb) View in Genome Browser

(Mouse) NCBIM37 - chr14:63817752..63890529 (72.78 kb) View in Genome Browser

(Rat) RGSC3.4 - chr15:42472793..42519569 (46.78 kb) View in Genome Browser

HaemAtlas Expression from HaemAtlas Top Help

HaemAtlas Expression Table for GATA4:

Beta Cell Expression from Beta Cell Gene Atlas Top Help

Cell Types Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Human					Mouse			Rat
ductal cells	exocrine pancreas	pancreatic islets	primary beta cells	Pancreatic Islets MPSS	beta cell line	pancreatic islets	whole pancreas	alpha cell	beta cell line	pancreatic islets	primary beta cells	whole pancreas

Expression Legend

Tissue Expression from GNF Gene Atlas Top Help

Tissues Showing Expression: Available

Users should be aware that the scale represents a rank within an experiment rather than a normalized expression signal.

Expression Legend

Interactions Top Help

Interactions Table for GATA4:

Cross-Reference to Pathways and GO Terms Top Help

View all

KEGG Network: None available

Biocarta: 3

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Gene Ontology: 59

RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977
RNA polymerase II transcription factor binding transcription factor activity	GO:0001076
In utero embryonic development	GO:0001701
Gastrulation with mouth forming second	GO:0001702
Endoderm formation	GO:0001706
Heart looping	GO:0001947
Heart morphogenesis	GO:0003007
Atrioventricular valve morphogenesis	GO:0003181
Endocardial cushion development	GO:0003197
Cardiac ventricle morphogenesis	GO:0003208
Cardiac right ventricle morphogenesis	GO:0003215
Ventricular cardiac muscle tissue development	GO:0003229
Ventricular septum development	GO:0003281
Atrial septum primum morphogenesis	GO:0003289
Atrial septum secundum morphogenesis	GO:0003290
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Sequence-specific DNA binding transcription factor activity	GO:0003700
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	GO:0003705
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Regulation of transcription, DNA-dependent	GO:0006355
Transcription from RNA polymerase II promoter	GO:0006366
Cell-cell signaling	GO:0007267
Spermatogenesis	GO:0007283
Endoderm development	GO:0007492
Blood coagulation	GO:0007596
Transcription factor binding	GO:0008134
Zinc ion binding	GO:0008270
Male gonad development	GO:0008584
Positive regulation vascular endothelial growth factor production	GO:0010575
Signal transduction involved in regulation of gene expression	GO:0023019
Positive regulation of BMP signaling pathway	GO:0030513
Response to retinoic acid	GO:0032526
Activating transcription factor binding	GO:0033613
Embryonic heart tube anterior/posterior pattern specification	GO:0035054
Response to drug	GO:0042493
Sequence-specific DNA binding	GO:0043565
Response to estrogen stimulus	GO:0043627
Transcription regulatory region DNA binding	GO:0044212
Positive regulation of angiogenesis	GO:0045766
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Metal ion binding	GO:0046872
Embryonic digestive tract morphogenesis	GO:0048557
Embryonic foregut morphogenesis	GO:0048617
Positive regulation of cardioblast differentiation	GO:0051891
Cardiac muscle cell differentiation	GO:0055007
Sertoli cell differentiation	GO:0060008
Positive regulation of cardiac muscle cell proliferation	GO:0060045
Canonical Wnt receptor signaling pathway	GO:0060070
SMAD protein signal transduction	GO:0060395
Atrial septum morphogenesis	GO:0060413
Lung lobe formation	GO:0060464
Intestinal epithelial cell differentiation	GO:0060575
Cellular response to follicle-stimulating hormone stimulus	GO:0071372
Epithelial cell fate commitment	GO:0072148
Seminiferous tubule development	GO:0072520

KEGG Network: None available

Biocarta: 3
ALK in cardiac myocytes	Human
Hop Pathway in Cardiac Development	Human	Mouse
NFAT and Hypertrophy of the heart (Transcription in the broken heart)	Human	Mouse

Reactome: None available

NCI-Nature Pathway Interaction Database: 1

Notch-mediated HES/HEY network

Gene Ontology: 59
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977
RNA polymerase II transcription factor binding transcription factor activity	GO:0001076
In utero embryonic development	GO:0001701
Gastrulation with mouth forming second	GO:0001702
Endoderm formation	GO:0001706
Heart looping	GO:0001947
Heart morphogenesis	GO:0003007
Atrioventricular valve morphogenesis	GO:0003181
Endocardial cushion development	GO:0003197
Cardiac ventricle morphogenesis	GO:0003208
Cardiac right ventricle morphogenesis	GO:0003215
Ventricular cardiac muscle tissue development	GO:0003229
Ventricular septum development	GO:0003281
Atrial septum primum morphogenesis	GO:0003289
Atrial septum secundum morphogenesis	GO:0003290
DNA binding	GO:0003677
Chromatin binding	GO:0003682
Sequence-specific DNA binding transcription factor activity	GO:0003700
Sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	GO:0003705
Protein binding	GO:0005515
Nucleus	GO:0005634
Nucleoplasm	GO:0005654
Regulation of transcription, DNA-dependent	GO:0006355
Transcription from RNA polymerase II promoter	GO:0006366
Cell-cell signaling	GO:0007267
Spermatogenesis	GO:0007283
Endoderm development	GO:0007492
Blood coagulation	GO:0007596
Transcription factor binding	GO:0008134
Zinc ion binding	GO:0008270
Male gonad development	GO:0008584
Positive regulation vascular endothelial growth factor production	GO:0010575
Signal transduction involved in regulation of gene expression	GO:0023019
Positive regulation of BMP signaling pathway	GO:0030513
Response to retinoic acid	GO:0032526
Activating transcription factor binding	GO:0033613
Embryonic heart tube anterior/posterior pattern specification	GO:0035054
Response to drug	GO:0042493
Sequence-specific DNA binding	GO:0043565
Response to estrogen stimulus	GO:0043627
Transcription regulatory region DNA binding	GO:0044212
Positive regulation of angiogenesis	GO:0045766
Positive regulation of transcription, DNA-dependent	GO:0045893
Positive regulation of transcription from RNA polymerase II promoter	GO:0045944
Metal ion binding	GO:0046872
Embryonic digestive tract morphogenesis	GO:0048557
Embryonic foregut morphogenesis	GO:0048617
Positive regulation of cardioblast differentiation	GO:0051891
Cardiac muscle cell differentiation	GO:0055007
Sertoli cell differentiation	GO:0060008
Positive regulation of cardiac muscle cell proliferation	GO:0060045
Canonical Wnt receptor signaling pathway	GO:0060070
SMAD protein signal transduction	GO:0060395
Atrial septum morphogenesis	GO:0060413
Lung lobe formation	GO:0060464
Intestinal epithelial cell differentiation	GO:0060575
Cellular response to follicle-stimulating hormone stimulus	GO:0071372
Epithelial cell fate commitment	GO:0072148
Seminiferous tubule development	GO:0072520

Publications from PubMed Top Help

Type 1 Diabetes Publications: 5

Publications: 516

PPARα activation inhibits endothelin-1-induced cardiomyocyte hypertrophy by prevention of NFATc4 binding to GATA-4.
Le K, Li R, Xu S, Wu X, Huang H, Bao Y, Cai Y, Lan T, Moss J, Li C, Zou J, Shen X, Liu P
Arch Biochem Biophys. 2012
PubMed ID: 22198280
ETS-dependent regulation of a distal Gata4 cardiac enhancer.
Schachterle W, Rojas A, Xu SM, Black BL
Dev Biol. 2012
PubMed ID: 22056786
PRC2 directly methylates GATA4 and represses its transcriptional activity.
He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, Wang G, Marquez VE, Orkin SH, Pu WT
Genes Dev. 2012
PubMed ID: 22215809
Myocardial Tbx20 regulates early atrioventricular canal formation and endocardial epithelial-mesenchymal transition via Bmp2.
Cai X, Nomura-Kitabayashi A, Cai W, Yan J, Christoffels VM, Cai CL
Dev Biol. 2011
PubMed ID: 21983003
Novel GATA4 mutations in lone atrial fibrillation.
Jiang JQ, Shen FF, Fang WY, Liu X, Yang YQ
Int J Mol Med. 2011
PubMed ID: 21874226
Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
Warren SA, Terada R, Briggs LE, Cole-Jeffrey CT, Chien WM, Seki T, Weinberg EO, Yang TP, Chin MT, Bungert J, Kasahara H
Mol Cell Biol. 2011
PubMed ID: 21930795
Essential roles of ECAT15-2/Dppa2 in functional lung development.
Nakamura T, Nakagawa M, Ichisaka T, Shiota A, Yamanaka S
Mol Cell Biol. 2011
PubMed ID: 21896782
GATA5 interacts with GATA4 and GATA6 in outflow tract development.
Laforest B, Nemer M
Dev Biol. 2011
PubMed ID: 21839733
Somatic mutations in NKX2–5, GATA4, and HAND1 are not a common cause of tetralogy of Fallot or hypoplastic left heart.
Esposito G, Butler TL, Blue GM, Cole AD, Sholler GF, Kirk EP, Grossfeld P, Perryman BM, Harvey RP, Winlaw DS
Am J Med Genet A. 2011
PubMed ID: 22043484
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
Harris RM, Weiss J, Jameson JL
Endocrinology. 2011
PubMed ID: 21791561
A novel GATA4 mutation responsible for congenital ventricular septal defects.
Wang J, Fang M, Liu XY, Xin YF, Liu ZM, Chen XZ, Wang XZ, Fang WY, Liu X, Yang YQ
Int J Mol Med. 2011
PubMed ID: 21637914
GATA4 specific nonsynonymous single-nucleotide polymorphisms in congenital heart disease patients of Mysore, India.
Dinesh SM, Lingaiah K, Savitha MR, Krishnamurthy B, Narayanappa D, Ramachandra NB
Genet Test Mol Biomarkers. 2011
PubMed ID: 21631294
Conserved GC-boxes, E-box and GATA motif are essential for GATA-4 gene expression in P19CL6 cells.
Ishibashi T, Yokura Y, Ohashi K, Yamamoto H, Maeda M
Biochem Biophys Res Commun. 2011
PubMed ID: 21878320
Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues.
Azhikina T, Kozlova A, Skvortsov T, Sverdlov E
Cancer Genet. 2011
PubMed ID: 22018271
Noncompaction of the left ventricular myocardium in a boy with a novel chromosome 8p23.1 deletion.
Blinder JJ, Martinez HR, Craigen WJ, Belmont J, Pignatelli RH, Jefferies JL
Am J Med Genet A. 2011
PubMed ID: 21834050
Ebstein anomaly: Genetic heterogeneity and association with microdeletions 1p36 and 8p23.1.
Digilio MC, Bernardini L, Lepri F, Giuffrida MG, Guida V, Baban A, Versacci P, Capolino R, Torres B, De Luca A, Novelli A, Marino B, Dallapiccola B
Am J Med Genet A. 2011
PubMed ID: 21815254
Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.
Salisch S, Klar M, Thurisch B, Bungert J, Dame C
J Cell Mol Med. 2011
PubMed ID: 21029371
Redundant and dosage sensitive requirements for Fgf3 and Fgf10 in cardiovascular development.
Urness LD, Bleyl SB, Wright TJ, Moon AM, Mansour SL
Dev Biol. 2011
PubMed ID: 21664901
Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development.
del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21768366
GATA-4 transcription factor regulates hepatic hepcidin expression.
Island ML, Fatih N, Leroyer P, Brissot P, Loreal O
Biochem J. 2011
PubMed ID: 21609320
GATA transcription factors regulate LHβ gene expression.
Lo A, Zheng W, Gong Y, Crochet JR, Halvorson LM
J Mol Endocrinol. 2011
PubMed ID: 21571865
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo.
van Berlo JH, Elrod JW, Aronow BJ, Pu WT, Molkentin JD
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21746915
Loss of Gata5 in mice leads to bicuspid aortic valve.
Laforest B, Andelfinger G, Nemer M
J Clin Invest. 2011
PubMed ID: 21633169
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.
Fernández-Miranda G, Trakala M, Martín J, Escobar B, González A, Ghyselinck NB, Ortega S, Cañamero M, Pérez de Castro I, Malumbres M
Development. 2011
PubMed ID: 21613325
GATA4 regulates estrogen receptor-alpha-mediated osteoblast transcription.
Miranda-Carboni GA, Guemes M, Bailey S, Anaya E, Corselli M, Peault B, Krum SA
Mol Endocrinol. 2011
PubMed ID: 21566084
Involvement of a novel GATA4 mutation in atrial septal defects.
Liu XY, Wang J, Zheng JH, Bai K, Liu ZM, Wang XZ, Liu X, Fang WY, Yang YQ
Int J Mol Med. 2011
PubMed ID: 21373748
miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors.
Crippa S, Cassano M, Messina G, Galli D, Galvez BG, Curk T, Altomare C, Ronzoni F, Toelen J, Gijsbers R, Debyser Z, Janssens S, Zupan B, Zaza A, Cossu G, Sampaolesi M
J Cell Biol. 2011
PubMed ID: 21708977
Investigation of somatic NKX2-5, GATA4 and HAND1 mutations in patients with tetralogy of Fallot.
Wang J, Lu Y, Chen H, Yin M, Yu T, Fu Q
Pathology. 2011
PubMed ID: 21519287
PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.
Chinchilla A, Daimi H, Lozano-Velasco E, Dominguez JN, Caballero R, Delpón E, Tamargo J, Cinca J, Hove-Madsen L, Aranega AE, Franco D
Circ Cardiovasc Genet. 2011
PubMed ID: 21511879
Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome.
Bagheri-Fam S, Argentaro A, Svingen T, Combes AN, Sinclair AH, Koopman P, Harley VR
Hum Mol Genet. 2011
PubMed ID: 21427128
Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.
Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG
Dev Biol. 2011
PubMed ID: 21385577
Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway.
Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, Kubota M, Noda M, Ogawa S, Shirato H, Sato M, Suzuki-Migishima R, Hino T, Satoh Y, Kitagawa M, Takeuchi T
Development. 2011
PubMed ID: 21447557
Search of somatic GATA4 and NKX2.5 gene mutations in sporadic septal heart defects.
Salazar M, Consoli F, Villegas V, Caicedo V, Maddaloni V, Daniele P, Caianiello G, Pachón S, Nuñez F, Limongelli G, Pacileo G, Marino B, Bernal JE, De Luca A, Dallapiccola B
Eur J Med Genet. 2011
PubMed ID: 21276881
GATA4 deficiency impairs ovarian function in adult mice.
Kyrönlahti A, Vetter M, Euler R, Bielinska M, Jay PY, Anttonen M, Heikinheimo M, Wilson DB
Biol Reprod. 2011
PubMed ID: 21248289
A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas.
Agnihotri S, Wolf A, Munoz DM, Smith CJ, Gajadhar A, Restrepo A, Clarke ID, Fuller GN, Kesari S, Dirks PB, McGlade CJ, Stanford WL, Aldape K, Mischel PS, Hawkins C, Guha A
J Exp Med. 2011
PubMed ID: 21464220
Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis.
del Monte G, Casanova JC, Guadix JA, MacGrogan D, Burch JB, Pérez-Pomares JM, de la Pompa JL
Circ Res. 2011
PubMed ID: 21311046
GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice.
Beuling E, Baffour-Awuah NY, Stapleton KA, Aronson BE, Noah TK, Shroyer NF, Duncan SA, Fleet JC, Krasinski SD
Gastroenterology. 2011
PubMed ID: 21262227
Two distinct origins for Leydig cell progenitors in the fetal testis.
DeFalco T, Takahashi S, Capel B
Dev Biol. 2011
PubMed ID: 21255566
Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart.
Park AM, Nagase H, Liu L, Vinod Kumar S, Szwergold N, Wong CM, Suzuki YJ
Cardiovasc Res. 2011
PubMed ID: 21084315
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21330551
Hand2 function in second heart field progenitors is essential for cardiogenesis.
Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D
Dev Biol. 2011
PubMed ID: 21185281
Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines.
Ito H, Yoshida K, Murakami M, Hagiwara K, Sasaki N, Kobayashi M, Takagi A, Kojima T, Sobue S, Suzuki M, Tamiya-Koizumi K, Nakamura M, Banno Y, Nozawa Y, Murate T
Biochim Biophys Acta. 2011
PubMed ID: 21184844
Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.
Patankar JV, Chandak PG, Obrowsky S, Pfeifer T, Diwoky C, Uellen A, Sattler W, Stollberger R, Hoefler G, Heinemann A, Battle M, Duncan S, Kratky D, Levak-Frank S
Am J Physiol Endocrinol Metab. 2011
PubMed ID: 21177287
Two regions within the proximal steroidogenic factor 1 promoter drive somatic cell-specific activity in developing gonads of the female mouse.
Gao L, Kim Y, Kim B, Lofgren SM, Schultz-Norton JR, Nardulli AM, Heckert LL, Jorgensen JS
Biol Reprod. 2011
PubMed ID: 20962249
Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation.
Wang Y, Smedberg JL, Cai KQ, Capo-Chichi DC, Xu XX
Dev Dyn. 2011
PubMed ID: 20925113
The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.
Artus J, Piliszek A, Hadjantonakis AK
Dev Biol. 2011
PubMed ID: 21146513
GATA4 regulates Sertoli cell function and fertility in adult male mice.
Kyrönlahti A, Euler R, Bielinska M, Schoeller EL, Moley KH, Toppari J, Heikinheimo M, Wilson DB
Mol Cell Endocrinol. 2011
PubMed ID: 21172404
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs.
Schlesinger J, Schueler M, Grunert M, Fischer JJ, Zhang Q, Krueger T, Lange M, Tönjes M, Dunkel I, Sperling SR
PLoS Genet. 2011
PubMed ID: 21379568
HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development.
Kueh AJ, Dixon MP, Voss AK, Thomas T
Mol Cell Biol. 2011
PubMed ID: 21149574
Loss-of-function mutation in GATA4 causes anomalies of human testicular development.
Lourenço D, Brauner R, Rybczynska M, Nihoul-Fékété C, McElreavey K, Bashamboo A
Proc Natl Acad Sci U S A. 2011
PubMed ID: 21220346
Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.
Kim B, Kim Y, Sakuma R, Hui CC, Rüther U, Jorgensen JS
Dev Biol. 2011
PubMed ID: 20969841
Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.
Oidovsambuu O, Nyamsuren G, Liu S, Göring W, Engel W, Adham IM
PLoS One. 2011
PubMed ID: 21991385
Overexpression of Csx/Nkx2.5 and GATA-4 enhances the efficacy of mesenchymal stem cell transplantation after myocardial infarction.
Gao XR, Tan YZ, Wang HJ
Circ J. 2011
PubMed ID: 21828931
Expression of Foxm1 transcription factor in cardiomyocytes is required for myocardial development.
Bolte C, Zhang Y, Wang IC, Kalin TV, Molkentin JD, Kalinichenko VV
PLoS One. 2011
PubMed ID: 21779394
Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA
PLoS One. 2011
PubMed ID: 21731673
Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility.
Ku PM, Chen LJ, Liang JR, Cheng KC, Li YX, Cheng JT
Cardiovasc Diabetol. 2011
PubMed ID: 21702924
Investigation of association between PFO complicated by cryptogenic stroke and a common variant of the cardiac transcription factor GATA4.
Moradi Marjaneh M, Kirk EP, Posch MG, Ozcelik C, Berger F, Hetzer R, Otway R, Butler TL, Blue GM, Griffiths LR, Fatkin D, Martinson JJ, Winlaw DS, Feneley MP, Harvey RP
PLoS One. 2011
PubMed ID: 21673957
The mammalian class 3 PI3K (PIK3C3) is required for early embryogenesis and cell proliferation.
Zhou X, Takatoh J, Wang F
PLoS One. 2011
PubMed ID: 21283715
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nürnberger A, Schmidt K, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, Garcia-Calero E, Kruse S, Uhr M, Kauck C, Feng G, Milyaev N, Ong CK, Kumar L, Lam M, Semple CA, Gyenesei A, Mundlos S, Radelof U, Lehrach H, Sarmientos P, Reymond A, Davidson DR, Dollé P, Antonarakis SE, Yaspo ML, Martinez S, Baldock RA, Eichele G, Ballabio A
PLoS Biol. 2011
PubMed ID: 21267068
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W
Development. 2011
PubMed ID: 21177343
Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos.
Song L, Zhao M, Wu B, Zhou B, Wang Q, Jiao K
Dev Dyn. 2011
PubMed ID: 21089072
Key roles of endothelin-1 and p38 MAPK in the regulation of atrial stretch response.
Kerkelä R, Ilves M, Pikkarainen S, Tokola H, Ronkainen VP, Majalahti T, Leppäluoto J, Vuolteenaho O, Ruskoaho H
Am J Physiol Regul Integr Comp Physiol. 2011
PubMed ID: 21084678
Ginseng inhibits cardiomyocyte hypertrophy and heart failure via NHE-1 inhibition and attenuation of calcineurin activation.
Guo J, Gan XT, Haist JV, Rajapurohitam V, Zeidan A, Faruq NS, Karmazyn M
Circ Heart Fail. 2011
PubMed ID: 20971938
Cyclin-dependent kinase 9 forms a complex with GATA4 and is involved in the differentiation of mouse ES cells into cardiomyocytes.
Kaichi S, Takaya T, Morimoto T, Sunagawa Y, Kawamura T, Ono K, Shimatsu A, Baba S, Heike T, Nakahata T, Hasegawa K
J Cell Physiol. 2011
PubMed ID: 20665673
Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease.
Peng T, Wang L, Zhou SF, Li X
Genetica. 2010
PubMed ID: 21110066
Pulmonary hypertension-induced GATA4 activation in the right ventricle.
Park AM, Wong CM, Jelinkova L, Liu L, Nagase H, Suzuki YJ
Hypertension. 2010
PubMed ID: 21059997
Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads.
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi K
Endocrinology. 2010
PubMed ID: 20962046
GATA4 mutations in 357 unrelated patients with congenital heart malformation.
Butler TL, Esposito G, Blue GM, Cole AD, Costa MW, Waddell LB, Walizada G, Sholler GF, Kirk EP, Feneley M, Harvey RP, Winlaw DS
Genet Test Mol Biomarkers. 2010
PubMed ID: 20874241
A novel mutation of GATA4 in a familial atrial septal defect.
Chen Y, Mao J, Sun Y, Zhang Q, Cheng HB, Yan WH, Choy KW, Li H
Clin Chim Acta. 2010
PubMed ID: 20659440
An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.
Nadeau M, Georges RO, Laforest B, Yamak A, Lefebvre C, Beauregard J, Paradis P, Bruneau BG, Andelfinger G, Nemer M
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20974940
Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.
Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG, Fan GC
J Mol Cell Cardiol. 2010
PubMed ID: 20708014
Wood smoke exposure and gene promoter methylation are associated with increased risk for COPD in smokers.
Sood A, Petersen H, Blanchette CM, Meek P, Picchi MA, Belinsky SA, Tesfaigzi Y
Am J Respir Crit Care Med. 2010
PubMed ID: 20595226
The transcription factor GATA-6 regulates pathological cardiac hypertrophy.
van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2010
PubMed ID: 20705924
Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer.
Rojas A, Schachterle W, Xu SM, Martín F, Black BL
Dev Biol. 2010
PubMed ID: 20692247
[Determination of GATA-4 in the testis of the mouse].
Yang JZ, Zhao YF, Wang YM, Jing CX, Miao NZ, Ai QY
Zhonghua Nan Ke Xue. 2010
PubMed ID: 21243753
[A novel GATA4 mutation leading to congenital ventricular septal defect].
Yang YQ, Tang YQ, Liu XY, Lin XP, Chen YH
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010
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Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators
Diabetes Care. 2010
PubMed ID: 20628086
Cardiomyocyte differentiation of rat bone marrow multipotent progenitor cells is associated with downregulation of Oct-4 expression.
Lu T, Pelacho B, Hao H, Luo M, Zhu J, Verfaillie CM, Tian J, Liu Z
Tissue Eng Part A. 2010
PubMed ID: 20486789
Vegf regulates embryonic erythroid development through Gata1 modulation.
Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ
Blood. 2010
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Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.
Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA
Dev Cell. 2010
PubMed ID: 20833366
GATA-4 promotes the differentiation of P19 cells into cardiac myocytes.
Hu DL, Chen FK, Liu YQ, Sheng YH, Yang R, Kong XQ, Cao KJ, Gu HT, Qian LM
Int J Mol Med. 2010
PubMed ID: 20664952
A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect.
Chen Y, Han ZQ, Yan WD, Tang CZ, Xie JY, Chen H, Hu DY
J Thorac Cardiovasc Surg. 2010
PubMed ID: 20347099
Nonmuscle myosin II isoform and domain specificity during early mouse development.
Wang A, Ma X, Conti MA, Liu C, Kawamoto S, Adelstein RS
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20679233
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors.
Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D
Cell. 2010
PubMed ID: 20691899
New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle.
De Luca A, Sarkozy A, Ferese R, Consoli F, Lepri F, Dentici ML, Vergara P, De Zorzi A, Versacci P, Digilio MC, Marino B, Dallapiccola B
Clin Genet. 2010
PubMed ID: 20807224
[Novel GATA4 mutations identified in patients with congenital atrial septal defects].
Liu XY, Yang YQ, Ma J, Lin XP, Zheng JH, Bai K, Chen YH
Zhonghua Xin Xue Guan Bing Za Zhi. 2010
PubMed ID: 21055141
Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment.
Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V
Development. 2010
PubMed ID: 20573702
Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism.
Messerschmidt DM, Kemler R
Dev Biol. 2010
PubMed ID: 20435031
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells.
Snyder M, Huang XY, Zhang JJ
J Biol Chem. 2010
PubMed ID: 20522556
Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.
Yoshida T, Gan Q, Franke AS, Ho R, Zhang J, Chen YE, Hayashi M, Majesky MW, Somlyo AV, Owens GK
J Biol Chem. 2010
PubMed ID: 20439457
Chromatin regulation by Brg1 underlies heart muscle development and disease.
Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP
Nature. 2010
PubMed ID: 20596014
Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.
Beuling E, Kerkhof IM, Nicksa GA, Giuffrida MJ, Haywood J, aan de Kerk DJ, Piaseckyj CM, Pu WT, Buchmiller TL, Dawson PA, Krasinski SD
Gut. 2010
PubMed ID: 20581237
Mutations in the cardiac transcription factor GATA4 in patients with lone atrial fibrillation.
Posch MG, Boldt LH, Polotzki M, Richter S, Rolf S, Perrot A, Dietz R, Ozcelik C, Haverkamp W
Eur J Med Genet. 2010
PubMed ID: 20363377
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.
Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Nöthen MM, Cichon S, Batra A, Berner M, Wodarz N, Zimmermann US, Spanagel R, Wiedemann K, Smolka MN, Heinz A, Rietschel M, Mann K
Pharmacogenomics J. 2010
PubMed ID: 20585342
The bHLH transcription factor CHF1/Hey2 regulates susceptibility to apoptosis and heart failure after pressure overload.
Liu Y, Yu M, Wu L, Chin MT
Am J Physiol Heart Circ Physiol. 2010
PubMed ID: 20382855
The transcription factor GATA-4 regulates cytochrome P4502C19 gene expression.
Mwinyi J, Hofmann Y, Pedersen RS, Nekvindová J, Cavaco I, Mkrtchian S, Ingelman-Sundberg M
Life Sci. 2010
PubMed ID: 20206639
[Genetic screening for novel GATA4 mutations associated with congenital atrial septal defect].
Wang J, Li XM, Xin YF, Wang LJ, Xu WJ, Hu DY
Zhonghua Xin Xue Guan Bing Za Zhi. 2010
PubMed ID: 20654103
Myogenic differentiation in atrium-derived adult cardiac pluripotent cells and the transcriptional regulation of GATA4 and myogenin on ANP promoter.
Kamrul Hasan M, Komoike Y, Tsunesumi S, Nakao R, Nagao H, Matsuoka R, Kawaguchi N
Genes Cells. 2010
PubMed ID: 20384792
Ets1 is required for proper migration and differentiation of the cardiac neural crest.
Gao Z, Kim GH, Mackinnon AC, Flagg AE, Bassett B, Earley JU, Svensson EC
Development. 2010
PubMed ID: 20356956
TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction.
Tsika RW, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, Fine DM, Hanft LM, McDonald KS, Molkentin JD, Krenz M, Yang S, Ji J
J Biol Chem. 2010
PubMed ID: 20194497
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.
Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET
Mol Cell. 2010
PubMed ID: 20417598
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Dev Cell. 2010
PubMed ID: 20412781
Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.
Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJ, Englert C, Petry M, Mommersteeg MT, Christoffels VM, Niederreither K, Kispert A
Circ Res. 2010
PubMed ID: 20185795
Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development.
Naillat F, Prunskaite-Hyyryläinen R, Pietilä I, Sormunen R, Jokela T, Shan J, Vainio SJ
Hum Mol Genet. 2010
PubMed ID: 20106871
Zac1 is an essential transcription factor for cardiac morphogenesis.
Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Prall OW, Harvey RP, Fukuda K
Circ Res. 2010
PubMed ID: 20167925
Hydroxysteroid (17beta) dehydrogenase 7 activity is essential for fetal de novo cholesterol synthesis and for neuroectodermal survival and cardiovascular differentiation in early mouse embryos.
Jokela H, Rantakari P, Lamminen T, Strauss L, Ola R, Mutka AL, Gylling H, Miettinen T, Pakarinen P, Sainio K, Poutanen M
Endocrinology. 2010
PubMed ID: 20185768
Cooperation between HNF-1alpha, Cdx2, and GATA-4 in initiating an enterocytic differentiation program in a normal human intestinal epithelial progenitor cell line.
Benoit YD, Paré F, Francoeur C, Jean D, Tremblay E, Boudreau F, Escaffit F, Beaulieu JF
Am J Physiol Gastrointest Liver Physiol. 2010
PubMed ID: 20133952
Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes.
Sunagawa Y, Morimoto T, Takaya T, Kaichi S, Wada H, Kawamura T, Fujita M, Shimatsu A, Kita T, Hasegawa K
J Biol Chem. 2010
PubMed ID: 20081228
Epicardial-myocardial signaling directing coronary vasculogenesis.
Olivey HE, Svensson EC
Circ Res. 2010
PubMed ID: 20299672
[Novel GATA4 mutations identified in patients with congenital heart disease]
Wang J, Hu DY, Li XM, Xin YF, Zhou H, Wang LJ, Wang LM, Xu WJ
Zhonghua Yi Xue Za Zhi. 2010
PubMed ID: 20450724
Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation.
Li P, Pashmforoush M, Sucov HM
Dev Cell. 2010
PubMed ID: 20230754
Methylation of GATA-4 and GATA-5 and development of sporadic gastric carcinomas.
Wen XZ, Akiyama Y, Pan KF, Liu ZJ, Lu ZM, Zhou J, Gu LK, Dong CX, Zhu BD, Ji JF, You WC, Deng DJ
World J Gastroenterol. 2010
PubMed ID: 20222162
An atlas of combinatorial transcriptional regulation in mouse and man.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y
Cell. 2010
PubMed ID: 20211142
Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11.
Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T
Alcohol Clin Exp Res. 2010
PubMed ID: 20201924
New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4.
Mwinyi J, Nekvindová J, Cavaco I, Hofmann Y, Pedersen RS, Landman E, Mkrtchian S, Ingelman-Sundberg M
Drug Metab Dispos. 2010
PubMed ID: 19995889
Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart.
Kratsios P, Catela C, Salimova E, Huth M, Berno V, Rosenthal N, Mourkioti F
Circ Res. 2010
PubMed ID: 20007915
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development.
Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE
Dev Cell. 2010
PubMed ID: 20159597
Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.
Gotic I, Leschnik M, Kolm U, Markovic M, Haubner BJ, Biadasiewicz K, Metzler B, Stewart CL, Foisner R
Circ Res. 2010
PubMed ID: 19926876
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal.
Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K
Genes Dev. 2010
PubMed ID: 20123909
Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.
Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y
Proc Natl Acad Sci U S A. 2010
PubMed ID: 20080709
Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice.
Singh MK, Li Y, Li S, Cobb RM, Zhou D, Lu MM, Epstein JA, Morrisey EE, Gruber PJ
J Biol Chem. 2010
PubMed ID: 19889636
c-kitpos GATA-4 high rat cardiac stem cells foster adult cardiomyocyte survival through IGF-1 paracrine signalling.
Kawaguchi N, Smith AJ, Waring CD, Hasan MK, Miyamoto S, Matsuoka R, Ellison GM
PLoS One. 2010
PubMed ID: 21179204
Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
Ikram MK, Xueling S, Jensen RA, Cotch MF, Hewitt AW, Ikram MA, Wang JJ, Klein R, Klein BE, Breteler MM, Cheung N, Liew G, Mitchell P, Uitterlinden AG, Rivadeneira F, Hofman A, de Jong PT, van Duijn CM, Kao L, Cheng CY, Smith AV, Glazer NL, Lumley T, McKnight B, Psaty BM, Jonasson F, Eiriksdottir G, Aspelund T, Global BPgen Consortium, Harris TB, Launer LJ, Taylor KD, Li X, Iyengar SK, Xi Q, Sivakumaran TA, Mackey DA, Macgregor S, Martin NG, Young TL, Bis JC, Wiggins KL, Heckbert SR, Hammond CJ, Andrew T, Fahy S, Attia J, Holliday EG, Scott RJ, Islam FM, Rotter JI, McAuley AK, Boerwinkle E, Tai ES, Gudnason V, Siscovick DS, Vingerling JR, Wong TY
PLoS Genet. 2010
PubMed ID: 21060863
Multiplex ligation-dependent probe amplification analysis of GATA4 gene copy number variations in patients with isolated congenital heart disease.
Guida V, Lepri F, Vijzelaar R, De Zorzi A, Versacci P, Digilio MC, Marino B, De Luca A, Dallapiccola B
Dis Markers. 2010
PubMed ID: 20592452
GATA4 protects granulosa cell tumors from TRAIL-induced apoptosis.
Kyrönlahti A, Kauppinen M, Lind E, Unkila-Kallio L, Butzow R, Klefström J, Wilson DB, Anttonen M, Heikinheimo M
Endocr Relat Cancer. 2010
PubMed ID: 20554787
Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.
Baur F, Nau K, Sadic D, Allweiss L, Elsässer HP, Gillemans N, de Wit T, Krüger I, Vollmer M, Philipsen S, Suske G
PLoS One. 2010
PubMed ID: 20221402
Aldosterone signaling associates with p300/GATA4 transcriptional pathway during the hypertrophic response of cardiomyocytes.
Yoshida Y, Morimoto T, Takaya T, Kawamura T, Sunagawa Y, Wada H, Fujita M, Shimatsu A, Kita T, Hasegawa K
Circ J. 2010
PubMed ID: 19966502
GATA4 mutations in Chinese patients with congenital cardiac septal defects.
Chen MW, Pang YS, Guo Y, Pan JH, Liu BL, Shen J, Liu TW
Pediatr Cardiol. 2010
PubMed ID: 19915893
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.
Kobayashi S, Volden P, Timm D, Mao K, Xu X, Liang Q
J Biol Chem. 2010
PubMed ID: 19901028
Gata4 directs development of cardiac-inducing endoderm from ES cells.
Holtzinger A, Rosenfeld GE, Evans T
Dev Biol. 2010
PubMed ID: 19850025
Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and beta-catenin expression.
Nagy II, Railo A, Rapila R, Hast T, Sormunen R, Tavi P, Räsänen J, Vainio SJ
Cardiovasc Res. 2010
PubMed ID: 19622544
Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development.
Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM, Cameron VA
Biochim Biophys Acta. 2009
PubMed ID: 19782130
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium
Am J Hum Genet. 2009
PubMed ID: 19913121
Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal.
Munger SC, Aylor DL, Syed HA, Magwene PM, Threadgill DW, Capel B
Genes Dev. 2009
PubMed ID: 19884258
Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism.
Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG
Cardiovasc Res. 2009
PubMed ID: 19546173
An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo.
Rojas A, Schachterle W, Xu SM, Black BL
Dev Dyn. 2009
PubMed ID: 19777593
Selective interaction between Trf3 and Taf3 required for early development and hematopoiesis.
Hart DO, Santra MK, Raha T, Green MR
Dev Dyn. 2009
PubMed ID: 19777587
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo.
Nichols J, Silva J, Roode M, Smith A
Development. 2009
PubMed ID: 19710168
Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads.
Thurisch B, Liang SY, Sarioglu N, Schomburg L, Bungert J, Dame C
J Mol Endocrinol. 2009
PubMed ID: 19491195
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.
Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ
J Clin Invest. 2009
PubMed ID: 19726871
Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects.
Berman SD, West JC, Danielian PS, Caron AM, Stone JR, Lees JA
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19706423
Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects.
Hamanoue H, Rahayuningsih SE, Hirahara Y, Itoh J, Yokoyama U, Mizuguchi T, Saitsu H, Miyake N, Hirahara F, Matsumoto N
Cardiol Young. 2009
PubMed ID: 19678963
VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies.
Pierre M, Yoshimoto M, Huang L, Richardson M, Yoder MC
Exp Hematol. 2009
PubMed ID: 19501129
GATA4 is a regulator of astrocyte cell proliferation and apoptosis in the human and murine central nervous system.
Agnihotri S, Wolf A, Picard D, Hawkins C, Guha A
Oncogene. 2009
PubMed ID: 19543315
GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.
Kodo K, Nishizawa T, Furutani M, Arai S, Yamamura E, Joo K, Takahashi T, Matsuoka R, Yamagishi H
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19666519
Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay.
Munshi NV, McAnally J, Bezprozvannaya S, Berry JM, Richardson JA, Hill JA, Olson EN
Development. 2009
PubMed ID: 19592579
Enhanced expression of transcription factor GATA-4 in inflammatory bowel disease and its possible regulation by TGF-beta1.
Haveri H, Ashorn M, Iltanen S, Wilson DB, Andersson LC, Heikinheimo M
J Clin Immunol. 2009
PubMed ID: 19353247
Cardiac differentiation is driven by NKX2.5 and GATA4 nuclear translocation in tissue-specific mesenchymal stem cells.
Armiñán A, Gandía C, Bartual M, García-Verdugo JM, Lledó E, Mirabet V, Llop M, Barea J, Montero JA, Sepúlveda P
Stem Cells Dev. 2009
PubMed ID: 18983250
GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.
Hellebrekers DM, Lentjes MH, van den Bosch SM, Melotte V, Wouters KA, Daenen KL, Smits KM, Akiyama Y, Yuasa Y, Sanduleanu S, Khalid-de Bakker CA, Jonkers D, Weijenberg MP, Louwagie J, van Criekinge W, Carvalho B, Meijer GA, Baylin SB, Herman JG, de Bruïne AP, van Engeland M
Clin Cancer Res. 2009
PubMed ID: 19509152
Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF).
Yoshimura K, Kitagawa H, Fujiki R, Tanabe M, Takezawa S, Takada I, Yamaoka I, Yonezawa M, Kondo T, Furutani Y, Yagi H, Yoshinaga S, Masuda T, Fukuda T, Yamamoto Y, Ebihara K, Li DY, Matsuoka R, Takeuchi JK, Matsumoto T, Kato S
Proc Natl Acad Sci U S A. 2009
PubMed ID: 19470456
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S
Anal Chem. 2009
PubMed ID: 19413330
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart.
Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT
J Clin Invest. 2009
PubMed ID: 19411759
Lineage-specific biology revealed by a finished genome assembly of the mouse.
Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP, Mouse Genome Sequencing Consortium
PLoS Biol. 2009
PubMed ID: 19468303
[Association between GATA-4 mutations and congenital cardiac septal defects in Han Chinese patients]
Chen MW, Pang YS, Guo Y, Liu BL, Shen J, Song HD, Liu TW
Zhonghua Xin Xue Guan Bing Za Zhi. 2009
PubMed ID: 19781215
A duplication including GATA4 does not co-segregate with congenital heart defects.
Joziasse IC, van der Smagt JJ, Poot M, Hochstenbach R, Nelen MR, van Gijn M, Dooijes D, Mulder BJ, Doevendans PA
Am J Med Genet A. 2009
PubMed ID: 19353638
Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes.
Zaglia T, Dedja A, Candiotto C, Cozzi E, Schiaffino S, Ausoni S
J Mol Cell Cardiol. 2009
PubMed ID: 19162035
MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes.
Ikeda S, He A, Kong SW, Lu J, Bejar R, Bodyak N, Lee KH, Ma Q, Kang PM, Golub TR, Pu WT
Mol Cell Biol. 2009
PubMed ID: 19188439
A negative feedback regulatory loop associates the tyrosine kinase receptor ERBB2 and the transcription factor GATA4 in breast cancer cells.
Hua G, Zhu B, Rosa F, Deblon N, Adélaïde J, Kahn-Perlès B, Birnbaum D, Imbert J
Mol Cancer Res. 2009
PubMed ID: 19276186
DNA binding-dependent and -independent functions of the Hand2 transcription factor during mouse embryogenesis.
Liu N, Barbosa AC, Chapman SL, Bezprozvannaya S, Qi X, Richardson JA, Yanagisawa H, Olson EN
Development. 2009
PubMed ID: 19211672
C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development.
Yang DH, Smith ER, Cai KQ, Xu XX
Dev Dyn. 2009
PubMed ID: 19191218
GATA4 and NKX2.5 gene analysis in Chinese Uygur patients with congenital heart disease.
Zhang WM, Li XF, Ma ZY, Zhang J, Zhou SH, Li T, Shi L, Li ZZ
Chin Med J (Engl). 2009
PubMed ID: 19302747
Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage.
Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D
J Neurosci. 2009
PubMed ID: 19228964
Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.
Maitra M, Schluterman MK, Nichols HA, Richardson JA, Lo CW, Srivastava D, Garg V
Dev Biol. 2009
PubMed ID: 19084512
The effect of human GATA4 gene mutations on the activity of target gonadal promoters.
Bouchard MF, Taniguchi H, Viger RS
J Mol Endocrinol. 2009
PubMed ID: 19008335
WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1.
Liu Z, Li T, Liu Y, Jia Z, Li Y, Zhang C, Chen P, Ma K, Affara N, Zhou C
Biochim Biophys Acta. 2009
PubMed ID: 18851995
Regulation of P450c17 expression in the early embryo depends on GATA factors.
Shi Y, Schonemann MD, Mellon SH
Endocrinology. 2009
PubMed ID: 18832096
Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.
Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H
J Cell Biol. 2009
PubMed ID: 19153222
Conserved usage of alternative 5' untranslated exons of the GATA4 gene.
Mazaud Guittot S, Bouchard MF, Robert-Grenon JP, Robert C, Goodyer CG, Silversides DW, Viger RS
PLoS One. 2009
PubMed ID: 20041118
The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.
Karafin MS, Cummings CT, Fu B, Iacobuzio-Donahue CA
Int J Clin Exp Pathol. 2009
PubMed ID: 19918328
Loss of GATA4 and GATA6 expression specifies ovarian cancer histological subtypes and precedes neoplastic transformation of ovarian surface epithelia.
Cai KQ, Caslini C, Capo-chichi CD, Slater C, Smith ER, Wu H, Klein-Szanto AJ, Godwin AK, Xu XX
PLoS One. 2009
PubMed ID: 19649254
Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex.
Manuylov NL, Tevosian SG
ScientificWorldJournal. 2009
PubMed ID: 19578715
MYC is a metastasis gene for non-small-cell lung cancer.
Rapp UR, Korn C, Ceteci F, Karreman C, Luetkenhaus K, Serafin V, Zanucco E, Castro I, Potapenko T
PLoS One. 2009
PubMed ID: 19551151
NKX2-5 regulates the expression of beta-catenin and GATA4 in ventricular myocytes.
Riazi AM, Takeuchi JK, Hornberger LK, Zaidi SH, Amini F, Coles J, Bruneau BG, Van Arsdell GS
PLoS One. 2009
PubMed ID: 19479054
Relation of Cardiotrophin-1 (CT-1) and cardiac transcription factor GATA4 expression in rat's cardiac myocytes hypertrophy and apoptosis.
He-nan Z, Yan W, Miao-na J, Cai-hua Z, Shen L, Yu-jie J
Pathol Res Pract. 2009
PubMed ID: 19327894
Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos.
Hirasawa R, Sasaki H
Gene Expr Patterns. 2009
PubMed ID: 18814855
Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.
Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bösl MR, Fässler R, Lickert H, Klein R
Genes Dev. 2008
PubMed ID: 19056886
Essential role of developmentally activated hypoxia-inducible factor 1alpha for cardiac morphogenesis and function.
Krishnan J, Ahuja P, Bodenmann S, Knapik D, Perriard E, Krek W, Perriard JC
Circ Res. 2008
PubMed ID: 18849322
[The expression of GATA-4 and Nkx2.5 gene in the transformation of Rattus mesenchymal stem cells into cardiomyocytes]
Wu CX, Zhang EY, Yang SY, Ma JY, An Q, Shi YK
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008
PubMed ID: 19253817
Ovarian development in mice requires the GATA4-FOG2 transcription complex.
Manuylov NL, Smagulova FO, Leach L, Tevosian SG
Development. 2008
PubMed ID: 18927154
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.
Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS
J Clin Invest. 2008
PubMed ID: 18830417
GATA4 is essential for jejunal function in mice.
Battle MA, Bondow BJ, Iverson MA, Adams SJ, Jandacek RJ, Tso P, Duncan SA
Gastroenterology. 2008
PubMed ID: 18812176
Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity.
Ma Q, Zhou B, Pu WT
Dev Biol. 2008
PubMed ID: 18775691
GATA-4 regulates Bcl-2 expression in ovarian granulosa cell tumors.
Kyrönlahti A, Rämö M, Tamminen M, Unkila-Kallio L, Butzow R, Leminen A, Nemer M, Rahman N, Huhtaniemi I, Heikinheimo M, Anttonen M
Endocrinology. 2008
PubMed ID: 18653721
Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis.
Cai KQ, Capo-Chichi CD, Rula ME, Yang DH, Xu XX
Dev Dyn. 2008
PubMed ID: 18816845
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.
Beuling E, Bosse T, aan de Kerk DJ, Piaseckyj CM, Fujiwara Y, Katz SG, Orkin SH, Grand RJ, Krasinski SD
Dev Biol. 2008
PubMed ID: 18692040
Serdin1/Lrrc10 is dispensable for mouse development.
Manuylov NL, Manuylova E, Avdoshina V, Tevosian S
Genesis. 2008
PubMed ID: 18781631
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst.
Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis AK
Development. 2008
PubMed ID: 18725515
GATA4 is a direct transcriptional activator of cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium.
Rojas A, Kong SW, Agarwal P, Gilliss B, Pu WT, Black BL
Mol Cell Biol. 2008
PubMed ID: 18591257
Crucial role of vHNF1 in vertebrate hepatic specification.
Lokmane L, Haumaitre C, Garcia-Villalba P, Anselme I, Schneider-Maunoury S, Cereghini S
Development. 2008
PubMed ID: 18635606
GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling.
Huang Y, Wright CD, Kobayashi S, Healy CL, Elgethun M, Cypher A, Liang Q, O'Connell TD
Am J Physiol Heart Circ Physiol. 2008
PubMed ID: 18552157
GATA4 mutations in 486 Chinese patients with congenital heart disease.
Zhang W, Li X, Shen A, Jiao W, Guan X, Li Z
Eur J Med Genet. 2008
PubMed ID: 18672102
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.
Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT
Nature. 2008
PubMed ID: 18568026
A myocardial lineage derives from Tbx18 epicardial cells.
Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM
Nature. 2008
PubMed ID: 18480752
Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.
Maretto S, Müller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ
Dev Biol. 2008
PubMed ID: 18448090
Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9.
Ohguchi H, Tanaka T, Uchida A, Magoori K, Kudo H, Kim I, Daigo K, Sakakibara I, Okamura M, Harigae H, Sasaki T, Osborne TF, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J
Mol Cell Biol. 2008
PubMed ID: 18426912
Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation.
Georges R, Nemer G, Morin M, Lefebvre C, Nemer M
Mol Cell Biol. 2008
PubMed ID: 18391012
Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice.
Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA
Dev Biol. 2008
PubMed ID: 18400219
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.
Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K
Cell Stem Cell. 2008
PubMed ID: 18462699
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice.
Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL
Proc Natl Acad Sci U S A. 2008
PubMed ID: 18448675
Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells.
Su D, Gudas LJ
Exp Hematol. 2008
PubMed ID: 18439490
Positive regulation of steroidogenic acute regulatory protein gene expression through the interaction between Dlx and GATA-4 for testicular steroidogenesis.
Nishida H, Miyagawa S, Vieux-Rochas M, Morini M, Ogino Y, Suzuki K, Nakagata N, Choi HS, Levi G, Yamada G
Endocrinology. 2008
PubMed ID: 18276760
Identification of downstream genetic pathways of Tbx1 in the second heart field.
Liao J, Aggarwal VS, Nowotschin S, Bondarev A, Lipner S, Morrow BE
Dev Biol. 2008
PubMed ID: 18328475
Identification of p300-targeted acetylated residues in GATA4 during hypertrophic responses in cardiac myocytes.
Takaya T, Kawamura T, Morimoto T, Ono K, Kita T, Shimatsu A, Hasegawa K
J Biol Chem. 2008
PubMed ID: 18252717
Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells.
Pilon N, Raiwet D, Viger RS, Silversides DW
Dev Dyn. 2008
PubMed ID: 18351674
GUDMAP: the genitourinary developmental molecular anatomy project.
McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project
J Am Soc Nephrol. 2008
PubMed ID: 18287559
GATA factors and androgen receptor collaborate to transcriptionally activate the Rhox5 homeobox gene in Sertoli cells.
Bhardwaj A, Rao MK, Kaur R, Buttigieg MR, Wilkinson MF
Mol Cell Biol. 2008
PubMed ID: 18212046
Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis.
Yin Z, Jones GN, Towns WH, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS
Circulation. 2008
PubMed ID: 18316483
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats.
Morimoto T, Sunagawa Y, Kawamura T, Takaya T, Wada H, Nagasawa A, Komeda M, Fujita M, Shimatsu A, Kita T, Hasegawa K
J Clin Invest. 2008
PubMed ID: 18292809
GATA-4 and GATA-6 expression in human ovarian surface epithelial carcinoma.
McEachin MD, Xu XX, Santoianni RA, Lawson D, Cotsonis G, Cohen C
Appl Immunohistochem Mol Morphol. 2008
PubMed ID: 18227727
SRG3, a core component of mouse SWI/SNF complex, is essential for extra-embryonic vascular development.
Han D, Jeon S, Sohn DH, Lee C, Ahn S, Kim WK, Chung H, Seong RH
Dev Biol. 2008
PubMed ID: 18206867
Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis.
Stankunas K, Hang CT, Tsun ZY, Chen H, Lee NV, Wu JI, Shang C, Bayle JH, Shou W, Iruela-Arispe ML, Chang CP
Dev Cell. 2008
PubMed ID: 18267097
Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects.
Posch MG, Perrot A, Schmitt K, Mittelhaus S, Esenwein EM, Stiller B, Geier C, Dietz R, Gessner R, Ozcelik C, Berger F
Am J Med Genet A. 2008
PubMed ID: 18076106
Investigation Between the S377G3 GATA-4 Polymorphism and Migraine.
Sherin C, Francesca F, Karl P, Brendan T, Ron H, Lyn G
Open Neurol J. 2008
PubMed ID: 19018306
GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development.
Smagulova FO, Manuylov NL, Leach LL, Tevosian SG
BMC Dev Biol. 2008
PubMed ID: 18577233
A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation.
Miyamoto Y, Taniguchi H, Hamel F, Silversides DW, Viger RS
BMC Mol Biol. 2008
PubMed ID: 18445271
Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa.
Haveri H, Westerholm-Ormio M, Lindfors K, Mäki M, Savilahti E, Andersson LC, Heikinheimo M
BMC Gastroenterol. 2008
PubMed ID: 18405344
Specific GATA-binding elements in the GnRH promoter are required for gene expression pulse activity: role of GATA-4 and GATA-5 in this intermittent process.
Leclerc GM, Bose SK, Boockfor FR
Neuroendocrinology. 2008
PubMed ID: 18259093
Mash1 is required for neuroendocrine cell development in the glandular stomach.
Kokubu H, Ohtsuka T, Kageyama R
Genes Cells. 2008
PubMed ID: 18173746
Identification of a chromosome 8p locus for early-onset coronary heart disease in a French Canadian population.
Engert JC, Lemire M, Faith J, Brisson D, Fujiwara TM, Roslin NM, Brewer CG, Montpetit A, Darmond-Zwaig C, Renaud Y, Doré C, Bailey SD, Verner A, Tremblay G, St-Pierre J, Bétard C, Platko J, Rioux JD, Morgan K, Hudson TJ, Gaudet D
Eur J Hum Genet. 2008
PubMed ID: 17805225
Induction of Id2 expression by cardiac transcription factors GATA4 and Nkx2.5.
Lim JY, Kim WH, Kim J, Park SI
J Cell Biochem. 2008
PubMed ID: 17559079
GATA4 sequence variants in patients with congenital heart disease.
Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E
J Med Genet. 2007
PubMed ID: 18055909
Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis.
Ijpenberg A, Pérez-Pomares JM, Guadix JA, Carmona R, Portillo-Sánchez V, Macías D, Hohenstein P, Miles CM, Hastie ND, Muñoz-Chápuli R
Dev Biol. 2007
PubMed ID: 18028902
Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester.
O'Shaughnessy PJ, Baker PJ, Monteiro A, Cassie S, Bhattacharya S, Fowler PA
J Clin Endocrinol Metab. 2007
PubMed ID: 17848411
Spectrum of heart disease associated with murine and human GATA4 mutation.
Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT
J Mol Cell Cardiol. 2007
PubMed ID: 17643447
Distinct roles of Wnt/beta-catenin and Bmp signaling during early cardiogenesis.
Klaus A, Saga Y, Taketo MM, Tzahor E, Birchmeier W
Proc Natl Acad Sci U S A. 2007
PubMed ID: 18000065
The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration.
Margagliotti S, Clotman F, Pierreux CE, Beaudry JB, Jacquemin P, Rousseau GG, Lemaigre FP
Dev Biol. 2007
PubMed ID: 17936262
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart.
Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Cromblehol TM, Molkentin JD
J Clin Invest. 2007
PubMed ID: 17975667
Isolation of cardiac cells from E8.5 yolk sac by ALCAM (CD166) expression.
Murakami Y, Hirata H, Miyamoto Y, Nagahashi A, Sawa Y, Jakt M, Asahara T, Kawamata S
Mech Dev. 2007
PubMed ID: 17964124
Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types.
Fu B, Guo M, Wang S, Campagna D, Luo M, Herman JG, Iacobuzio-Donahue CA
Cancer Biol Ther. 2007
PubMed ID: 17912029
Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.
Hatch EP, Noyes CA, Wang X, Wright TJ, Mansour SL
Development. 2007
PubMed ID: 17855431
Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.
Bouma GJ, Washburn LL, Albrecht KH, Eicher EM
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17848526
Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A
J Biol Chem. 2007
PubMed ID: 17584735
Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles.
Philips AS, Kwok JC, Chong BH
J Biol Chem. 2007
PubMed ID: 17548362
Myocardial smad4 is essential for cardiogenesis in mouse embryos.
Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K
Circ Res. 2007
PubMed ID: 17585069
Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.
Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM
Mol Cell Biol. 2007
PubMed ID: 17526730
Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury.
Kobayashi S, Mao K, Zheng H, Wang X, Patterson C, O'Connell TD, Liang Q
J Biol Chem. 2007
PubMed ID: 17525155
The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models.
Manuylov NL, Fujiwara Y, Adameyko II, Poulat F, Tevosian SG
Dev Biol. 2007
PubMed ID: 17540364
Effect of cell-based intercellular delivery of transcription factor GATA4 on ischemic cardiomyopathy.
Bian J, Popovic ZB, Benejam C, Kiedrowski M, Rodriguez LL, Penn MS
Circ Res. 2007
PubMed ID: 17495229
An alternative transcript of the FOG-2 gene encodes a FOG-2 isoform lacking the FOG repression motif.
Dale RM, Remo BF, Svensson EC
Biochem Biophys Res Commun. 2007
PubMed ID: 17445768
Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice.
Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S
Genes Cells. 2007
PubMed ID: 17573777
Transcription factors Csx/Nkx2.5 and GATA4 distinctly regulate expression of Ca2+ channels in neonatal rat heart.
Wang Y, Morishima M, Zheng M, Uchino T, Mannen K, Takahashi A, Nakaya Y, Komuro I, Ono K
J Mol Cell Cardiol. 2007
PubMed ID: 17498735
Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8.
Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, Ohguchi H, Okamura M, Kudo H, Daigo K, Maejima T, Kojima N, Sakakibara I, Jiang S, Hasegawa G, Kim I, Osborne TF, Naito M, Gonzalez FJ, Hamakubo T, Kodama T, Sakai J
Mol Cell Biol. 2007
PubMed ID: 17403900
Cooperation between GATA4 and TGF-beta signaling regulates intestinal epithelial gene expression.
Belaguli NS, Zhang M, Rigi M, Aftab M, Berger DH
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17290010
Oct-4, Rex-1, and Gata-4 expression in human MSC increase the differentiation efficiency but not hTERT expression.
Roche S, Richard MJ, Favrot MC
J Cell Biochem. 2007
PubMed ID: 17211834
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.
Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Srivastava D, Nakagawa O, Olson EN
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17468400
Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.
Hoogaars WM, Engel A, Brons JF, Verkerk AO, de Lange FJ, Wong LY, Bakker ML, Clout DE, Wakker V, Barnett P, Ravesloot JH, Moorman AF, Verheijck EE, Christoffels VM
Genes Dev. 2007
PubMed ID: 17473172
Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development.
Bosse T, Fialkovich JJ, Piaseckyj CM, Beuling E, Broekman H, Grand RJ, Montgomery RK, Krasinski SD
Am J Physiol Gastrointest Liver Physiol. 2007
PubMed ID: 17272516
Disabled-2 is an epithelial surface positioning gene.
Yang DH, Cai KQ, Roland IH, Smith ER, Xu XX
J Biol Chem. 2007
PubMed ID: 17339320
Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.
Schluterman MK, Krysiak AE, Kathiriya IS, Abate N, Chandalia M, Srivastava D, Garg V
Am J Med Genet A. 2007
PubMed ID: 17352393
Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor.
Ramakrishna S, Kim IM, Petrovic V, Malin D, Wang IC, Kalin TV, Meliton L, Zhao YY, Ackerson T, Qin Y, Malik AB, Costa RH, Kalinichenko VV
Dev Dyn. 2007
PubMed ID: 17366632
FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.
Flagg AE, Earley JU, Svensson EC
Dev Biol. 2007
PubMed ID: 17274974
Follicle-stimulating hormone-induced activation of Gata4 contributes in the up-regulation of Cyp19 expression in rat granulosa cells.
Kwintkiewicz J, Cai Z, Stocco C
Mol Endocrinol. 2007
PubMed ID: 17227882
Gata4 is necessary for normal pulmonary lobar development.
Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR
Am J Respir Cell Mol Biol. 2007
PubMed ID: 17142311
CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression.
Koibuchi N, Chin MT
Circ Res. 2007
PubMed ID: 17332425
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.
Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M
Circ Res. 2007
PubMed ID: 17303760
Maternal microRNAs are essential for mouse zygotic development.
Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA
Genes Dev. 2007
PubMed ID: 17369397
Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells.
Liu Y, Asakura M, Inoue H, Nakamura T, Sano M, Niu Z, Chen M, Schwartz RJ, Schneider MD
Proc Natl Acad Sci U S A. 2007
PubMed ID: 17360443
Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells.
Kaji K, Nichols J, Hendrich B
Development. 2007
PubMed ID: 17287250
Single-cell-derived mesenchymal stem cells overexpressing Csx/Nkx2.5 and GATA4 undergo the stochastic cardiomyogenic fate and behave like transient amplifying cells.
Yamada Y, Sakurada K, Takeda Y, Gojo S, Umezawa A
Exp Cell Res. 2007
PubMed ID: 17208226
Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects.
Jay PY, Bielinska M, Erlich JM, Mannisto S, Pu WT, Heikinheimo M, Wilson DB
Dev Biol. 2007
PubMed ID: 17069789
WT1-mediated gene regulation in early urogenital ridge development.
Klattig J, Sierig R, Kruspe D, Makki MS, Englert C
Sex Dev. 2007
PubMed ID: 18391535
Combined haploinsufficiency of SF-1 and GATA4 does not reveal a genetic interaction in mouse gonadal development.
Pelusi C, Zhao L, Stallings NR, Parker KL
Sex Dev. 2007
PubMed ID: 18391526
Extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells.
Shimosato D, Shiki M, Niwa H
BMC Dev Biol. 2007
PubMed ID: 17605826
Mutations in the 3'-untranslated region of GATA4 as molecular hotspots for congenital heart disease (CHD).
Reamon-Buettner SM, Cho SH, Borlak J
BMC Med Genet. 2007
PubMed ID: 17592645
Development of the mammalian liver and ventral pancreas is dependent on GATA4.
Watt AJ, Zhao R, Li J, Duncan SA
BMC Dev Biol. 2007
PubMed ID: 17451603
GATA-4 is required for sex steroidogenic cell development in the fetal mouse.
Bielinska M, Seehra A, Toppari J, Heikinheimo M, Wilson DB
Dev Dyn. 2007
PubMed ID: 17096405
The proximal Gata4 promoter directs reporter gene expression to sertoli cells during mouse gonadal development.
Mazaud Guittot S, Tétu A, Legault E, Pilon N, Silversides DW, Viger RS
Biol Reprod. 2007
PubMed ID: 17021344
Nuclear receptor NR5A2 is required for proper primitive streak morphogenesis.
Labelle-Dumais C, Jacob-Wagner M, Paré JF, Bélanger L, Dufort D
Dev Dyn. 2006
PubMed ID: 17075876
Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine.
Bosse T, Piaseckyj CM, Burghard E, Fialkovich JJ, Rajagopal S, Pu WT, Krasinski SD
Mol Cell Biol. 2006
PubMed ID: 16940177
Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart.
Risebro CA, Smart N, Dupays L, Breckenridge R, Mohun TJ, Riley PR
Development. 2006
PubMed ID: 17050624
Hypermethylation of the GATA gene family in esophageal cancer.
Guo M, House MG, Akiyama Y, Qi Y, Capagna D, Harmon J, Baylin SB, Brock MV, Herman JG
Int J Cancer. 2006
PubMed ID: 16823849
GATA-4 incompletely substitutes for GATA-1 in promoting both primitive and definitive erythropoiesis in vivo.
Hosoya-Ohmura S, Mochizuki N, Suzuki M, Ohneda O, Ohneda K, Yamamoto M
J Biol Chem. 2006
PubMed ID: 16945928
Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis.
Karamboulas C, Dakubo GD, Liu J, De Repentigny Y, Yutzey K, Wallace VA, Kothary R, Skerjanc IS
J Cell Sci. 2006
PubMed ID: 17003108
Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis.
Wakana K, Akiyama Y, Aso T, Yuasa Y
Cancer Lett. 2006
PubMed ID: 16337738
Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure.
Bisping E, Ikeda S, Kong SW, Tarnavski O, Bodyak N, McMullen JR, Rajagopal S, Son JK, Ma Q, Springer Z, Kang PM, Izumo S, Pu WT
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16983087
Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis.
Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG
Dev Biol. 2006
PubMed ID: 16870172
Development of heart valves requires Gata4 expression in endothelial-derived cells.
Rivera-Feliciano J, Lee KH, Kong SW, Rajagopal S, Ma Q, Springer Z, Izumo S, Tabin CJ, Pu WT
Development. 2006
PubMed ID: 16914500
Histone modifications silence the GATA transcription factor genes in ovarian cancer.
Caslini C, Capo-chichi CD, Roland IH, Nicolas E, Yeung AT, Xu XX
Oncogene. 2006
PubMed ID: 16607277
A threshold of GATA4 and GATA6 expression is required for cardiovascular development.
Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN
Proc Natl Acad Sci U S A. 2006
PubMed ID: 16847256
The mouse gcd2 mutation causes primordial germ cell depletion.
Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC
Mech Dev. 2006
PubMed ID: 16822657
Transcriptional activation of the steroidogenic acute regulatory protein (StAR) gene: GATA-4 and CCAAT/enhancer-binding protein beta confer synergistic responsiveness in hormone-treated rat granulosa and HEK293 cell models.
Silverman E, Yivgi-Ohana N, Sher N, Bell M, Eimerl S, Orly J
Mol Cell Endocrinol. 2006
PubMed ID: 16682116
p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins.
Ding B, Liu CJ, Huang Y, Yu J, Kong W, Lengyel P
J Biol Chem. 2006
PubMed ID: 16556596
p204 is required for the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes: its expression is activated by the cardiac Gata4, Nkx2.5, and Tbx5 proteins.
Ding B, Liu CJ, Huang Y, Hickey RP, Yu J, Kong W, Lengyel P
J Biol Chem. 2006
PubMed ID: 16556595
Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.
Goldman DC, Hackenmiller R, Nakayama T, Sopory S, Wong C, Kulessa H, Christian JL
Development. 2006
PubMed ID: 16624858
Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4.
Xiang F, Sakata Y, Cui L, Youngblood JM, Nakagami H, Liao JK, Liao R, Chin MT
Am J Physiol Heart Circ Physiol. 2006
PubMed ID: 16603706
Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.
Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki K, Kanno J, Saga Y
Development. 2006
PubMed ID: 16554359
Wnt2 is a direct downstream target of GATA6 during early cardiogenesis.
Alexandrovich A, Arno M, Patient RK, Shah AM, Pizzey JA, Brewer AC
Mech Dev. 2006
PubMed ID: 16621466
Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling.
Spencer-Dene B, Sala FG, Bellusci S, Gschmeissner S, Stamp G, Dickson C
Gastroenterology. 2006
PubMed ID: 16618415
Two novel missense mutations of GATA4 gene in Chinese patients with sporadic congenital heart defects.
Tang ZH, Xia L, Chang W, Li H, Shen F, Liu JY, Wang Q, Liu MG
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006
PubMed ID: 16604480
The TGF beta activated kinase TAK1 regulates vascular development in vivo.
Jadrich JL, O'Connor MB, Coucouvanis E
Development. 2006
PubMed ID: 16556914
PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains.
Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, Noda T
Development. 2006
PubMed ID: 16510507
Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability.
Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD
Circ Res. 2006
PubMed ID: 16514068
In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4.
Mao C, Tai WC, Bai Y, Poizat C, Lee AS
J Biol Chem. 2006
PubMed ID: 16452489
GATA-4 gene organization and analysis of its promoter.
Ohara Y, Atarashi T, Ishibashi T, Ohashi-Kobayashi A, Maeda M
Biol Pharm Bull. 2006
PubMed ID: 16508137
A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot.
Nemer G, Fadlalah F, Usta J, Nemer M, Dbaibo G, Obeid M, Bitar F
Hum Mutat. 2006
PubMed ID: 16470721
Crucial transcription factors in endoderm and embryonic gut development are expressed in gut-like structures from mouse ES cells.
Matsuura R, Kogo H, Ogaeri T, Miwa T, Kuwahara M, Kanai Y, Nakagawa T, Kuroiwa A, Fujimoto T, Torihashi S
Stem Cells. 2006
PubMed ID: 16210401
The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.
Mattiske D, Kume T, Hogan BL
Dev Biol. 2006
PubMed ID: 16412416
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart.
Koshiba-Takeuchi K, Takeuchi JK, Arruda EP, Kathiriya IS, Mo R, Hui CC, Srivastava D, Bruneau BG
Nat Genet. 2006
PubMed ID: 16380715
Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.
Bort R, Signore M, Tremblay K, Martinez Barbera JP, Zaret KS
Dev Biol. 2006
PubMed ID: 16364283
DNA sequence and analysis of human chromosome 8.
Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L, Engels R, Glöckner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES
Nature. 2006
PubMed ID: 16421571
Screening of 99 Danish patients with congenital heart disease for GATA4 mutations.
Zhang L, Tümer Z, Jacobsen JR, Andersen PS, Tommerup N, Larsen LA
Genet Test. 2006
PubMed ID: 17253934
Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors.
Ema M, Takahashi S, Rossant J
Blood. 2006
PubMed ID: 16166582
GATA4-mediated cardiac hypertrophy induced by d-myo-inositol 1,4,5-tris-phosphate.
Zhu Z, Zhu S, Liu D, Yu Z, Yang Y, van der Giet M, Tepel M
Biochem Biophys Res Commun. 2005
PubMed ID: 16259952
Odd-skipped related 1 (Odd 1) is an essential regulator of heart and urogenital development.
Wang Q, Lan Y, Cho ES, Maltby KM, Jiang R
Dev Biol. 2005
PubMed ID: 16223478
Transcriptome analysis of human gastric cancer.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS
Mamm Genome. 2005
PubMed ID: 16341674
Mammalian E4 is required for cardiac development and maintenance of the nervous system.
Kaneko-Oshikawa C, Nakagawa T, Yamada M, Yoshikawa H, Matsumoto M, Yada M, Hatakeyama S, Nakayama K, Nakayama KI
Mol Cell Biol. 2005
PubMed ID: 16314518
High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors.
Anttonen M, Unkila-Kallio L, Leminen A, Butzow R, Heikinheimo M
J Clin Endocrinol Metab. 2005
PubMed ID: 16159935
Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4.
Wang J, Paradis P, Aries A, Komati H, Lefebvre C, Wang H, Nemer M
Mol Cell Biol. 2005
PubMed ID: 16260600
Apical membrane and junctional complex formation during simple epithelial cell differentiation of F9 cells.
Komiya S, Shimizu M, Ikenouchi J, Yonemura S, Matsui T, Fukunaga Y, Liu H, Endo F, Tsukita S, Nagafuchi A
Genes Cells. 2005
PubMed ID: 16236135
Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells.
Capo-Chichi CD, Rula ME, Smedberg JL, Vanderveer L, Parmacek MS, Morrisey EE, Godwin AK, Xu XX
Dev Biol. 2005
PubMed ID: 16162334
Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts.
Fischer A, Klattig J, Kneitz B, Diez H, Maier M, Holtmann B, Englert C, Gessler M
Mol Cell Biol. 2005
PubMed ID: 16199874
The zinc finger-only protein Zfp260 is a novel cardiac regulator and a nuclear effector of alpha1-adrenergic signaling.
Debrus S, Rahbani L, Marttila M, Delorme B, Paradis P, Nemer M
Mol Cell Biol. 2005
PubMed ID: 16166646
GATA-4:FOG interactions regulate gastric epithelial development in the mouse.
Jacobsen CM, Mannisto S, Porter-Tinge S, Genova E, Parviainen H, Heikinheimo M, Adameyko II, Tevosian SG, Wilson DB
Dev Dyn. 2005
PubMed ID: 16127717
Generation of a conditionally null allele of the laminin alpha1 gene.
Alpy F, Jivkov I, Sorokin L, Klein A, Arnold C, Huss Y, Kedinger M, Simon-Assmann P, Lefebvre O
Genesis. 2005
PubMed ID: 16100707
Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets.
Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ
J Biol Chem. 2005
PubMed ID: 15929941
Antisense transcription in the mammalian transcriptome.
Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, Ravasi T, Pang KC, Hallinan J, Mattick J, Hume DA, Lipovich L, Batalov S, Engström PG, Mizuno Y, Faghihi MA, Sandelin A, Chalk AM, Mottagui-Tabar S, Liang Z, Lenhard B, Wahlestedt C, RIKEN Genome Exploration Research Group, Genome Science Group (Genome Network Project Core Group), FANTOM Consortium
Science. 2005
PubMed ID: 16141073
The transcriptional landscape of the mammalian genome.
Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schönbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science. 2005
PubMed ID: 16141072
Transcription factors GATA-4 and GATA-6, and their potential downstream effectors in ovarian germ cell tumors.
Mannisto S, Butzow R, Salonen J, Leminen A, Heikinheimo O, Heikinheimo M
Tumour Biol. 2005
PubMed ID: 16110260
GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis.
Brewer AC, Alexandrovich A, Mjaatvedt CH, Shah AM, Patient RK, Pizzey JA
Stem Cells Dev. 2005
PubMed ID: 16137232
Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element.
Rojas A, De Val S, Heidt AB, Xu SM, Bristow J, Black BL
Development. 2005
PubMed ID: 15987774
GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts.
Wang L, Tanaka S, Ramirez F
Matrix Biol. 2005
PubMed ID: 15982862
Irx3 is differentially up-regulated in female gonads during sex determination.
Jorgensen JS, Gao L
Gene Expr Patterns. 2005
PubMed ID: 15963769
Foxl2 is required for commitment to ovary differentiation.
Ottolenghi C, Omari S, Garcia-Ortiz JE, Uda M, Crisponi L, Forabosco A, Pilia G, Schlessinger D
Hum Mol Genet. 2005
PubMed ID: 15944199
Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh.
Briegel KJ, Baldwin HS, Epstein JA, Joyner AL
Development. 2005
PubMed ID: 15958514
Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells.
Bouma GJ, Albrecht KH, Washburn LL, Recknagel AK, Churchill GA, Eicher EM
Development. 2005
PubMed ID: 15944188
Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis.
Raverot G, Weiss J, Park SY, Hurley L, Jameson JL
Dev Biol. 2005
PubMed ID: 15893302
Morphogenesis of the right ventricle requires myocardial expression of Gata4.
Zeisberg EM, Ma Q, Juraszek AL, Moses K, Schwartz RJ, Izumo S, Pu WT
J Clin Invest. 2005
PubMed ID: 15902305
Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2.
Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Bürger A, Ericson J, Kispert A
Development. 2005
PubMed ID: 15901664
Expression and regulation of mouse SERDIN1, a highly conserved cardiac-specific leucine-rich repeat protein.
Adameyko II, Mudry RE, Houston-Cummings NR, Veselov AP, Gregorio CC, Tevosian SG
Dev Dyn. 2005
PubMed ID: 15830381
Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes.
Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, Morisaki T, Heike T, Nakahata T, Kita T, Hasegawa K
J Biol Chem. 2005
PubMed ID: 15764815
Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect.
Hirayama-Yamada K, Kamisago M, Akimoto K, Aotsuka H, Nakamura Y, Tomita H, Furutani M, Imamura S, Takao A, Nakazawa M, Matsuoka R
Am J Med Genet A. 2005
PubMed ID: 15810002
Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation.
Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP
Development. 2005
PubMed ID: 15843414
Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development.
Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG
Development. 2005
PubMed ID: 15843409
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.
Cai CL, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Li X, Rosenfeld MG, Chen J, Evans S
Development. 2005
PubMed ID: 15843407
A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad.
Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, Shimada K, Morohashi K
Genes Cells. 2005
PubMed ID: 15836771
COUP-TFII is essential for radial and anteroposterior patterning of the stomach.
Takamoto N, You LR, Moses K, Chiang C, Zimmer WE, Schwartz RJ, DeMayo FJ, Tsai MJ, Tsai SY
Development. 2005
PubMed ID: 15829524
GATA6 is essential for embryonic development of the liver but dispensable for early heart formation.
Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA
Mol Cell Biol. 2005
PubMed ID: 15767668
Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation.
Makita T, Duncan SA, Sucov HM
Dev Biol. 2005
PubMed ID: 15766748
Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells.
Escaffit F, Boudreau F, Beaulieu JF
J Cell Physiol. 2005
PubMed ID: 15389642
CSX/Nkx2.5 modulates differentiation of skeletal myoblasts and promotes differentiation into neuronal cells in vitro.
Riazi AM, Lee H, Hsu C, Van Arsdell G
J Biol Chem. 2005
PubMed ID: 15653675
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway.
Wang X, Merritt AJ, Seyfried J, Guo C, Papadakis ES, Finegan KG, Kayahara M, Dixon J, Boot-Handford RP, Cartwright EJ, Mayer U, Tournier C
Mol Cell Biol. 2005
PubMed ID: 15601854
Mouse brain organization revealed through direct genome-scale TF expression analysis.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q
Science. 2004
PubMed ID: 15618518
The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells.
van der Sluis M, Melis MH, Jonckheere N, Ducourouble MP, Büller HA, Renes I, Einerhand AW, Van Seuningen I
Biochem Biophys Res Commun. 2004
PubMed ID: 15541382
Hypermethylation of the GATA genes in lung cancer.
Guo M, Akiyama Y, House MG, Hooker CM, Heath E, Gabrielson E, Yang SC, Han Y, Baylin SB, Herman JG, Brock MV
Clin Cancer Res. 2004
PubMed ID: 15585625
Sox7 plays crucial roles in parietal endoderm differentiation in F9 embryonal carcinoma cells through regulating Gata-4 and Gata-6 expression.
Futaki S, Hayashi Y, Emoto T, Weber CN, Sekiguchi K
Mol Cell Biol. 2004
PubMed ID: 15542856
Jumonji represses atrial natriuretic factor gene expression by inhibiting transcriptional activities of cardiac transcription factors.
Kim TG, Chen J, Sadoshima J, Lee Y
Mol Cell Biol. 2004
PubMed ID: 15542826
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.
Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH
Dev Biol. 2004
PubMed ID: 15531365
SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.
Wang J, Feng XH, Schwartz RJ
J Biol Chem. 2004
PubMed ID: 15337742
Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.
Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, Adamson SL, Henkelman RM, Wrana JL, Rossant J, Bruneau BG
Nature. 2004
PubMed ID: 15525990
Transcription factors GATA-4 and GATA-6 in human adrenocortical tumors.
Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M
Endocr Res. 2004
PubMed ID: 15666845
Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development.
Bouma GJ, Hart GT, Washburn LL, Recknagel AK, Eicher EM
Gene Expr Patterns. 2004
PubMed ID: 15533830
GATA4 is a dosage-sensitive regulator of cardiac morphogenesis.
Pu WT, Ishiwata T, Juraszek AL, Ma Q, Izumo S
Dev Biol. 2004
PubMed ID: 15464586
In vivo and in vitro inhibition of cyp19 gene expression by prostaglandin F2alpha in murine luteal cells: implication of GATA-4.
Stocco C
Endocrinology. 2004
PubMed ID: 15271885
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J, MGC Project Team
Genome Res. 2004
PubMed ID: 15489334
Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice.
Conti MA, Even-Ram S, Liu C, Yamada KM, Adelstein RS
J Biol Chem. 2004
PubMed ID: 15292239
Adrenocortical tumorigenesis in transgenic mice expressing the inhibin alpha-subunit promoter/simian virus 40 T-antigen transgene: relationship between ectopic expression of luteinizing hormone receptor and transcription factor GATA-4.
Rahman NA, Kiiveri S, Rivero-Müller A, Levallet J, Vierre S, Kero J, Wilson DB, Heikinheimo M, Huhtaniemi I
Mol Endocrinol. 2004
PubMed ID: 15256532
Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4.
van Wering HM, Bosse T, Musters A, de Jong E, de Jong N, Hogen Esch CE, Boudreau F, Swain GP, Dowling LN, Montgomery RK, Grand RJ, Krasinski SD
Am J Physiol Gastrointest Liver Physiol. 2004
PubMed ID: 15178553
FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes.
Hirai M, Ono K, Morimoto T, Kawamura T, Wada H, Kita T, Hasegawa K
J Biol Chem. 2004
PubMed ID: 15220332
Foxh1 is essential for development of the anterior heart field.
von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL
Dev Cell. 2004
PubMed ID: 15363409
GATA4 is essential for formation of the proepicardium and regulates cardiogenesis.
Watt AJ, Battle MA, Li J, Duncan SA
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15310850
SOX7 and GATA-4 are competitive activators of Fgf-3 transcription.
Murakami A, Shen H, Ishida S, Dickson C
J Biol Chem. 2004
PubMed ID: 15082719
A novel GATA4 mutation completely segregated with atrial septal defect in a large Japanese family.
Okubo A, Miyoshi O, Baba K, Takagi M, Tsukamoto K, Kinoshita A, Yoshiura K, Kishino T, Ohta T, Niikawa N, Matsumoto N
J Med Genet. 2004
PubMed ID: 15235040
One tissue, two fates: molecular genetic events that underlie testis versus ovary development.
Brennan J, Capel B
Nat Rev Genet. 2004
PubMed ID: 15211353
The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation.
Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M
Mol Cell Biol. 2004
PubMed ID: 15199142
Mitogen-activated protein kinases p38 and ERK 1/2 mediate the wall stress-induced activation of GATA-4 binding in adult heart.
Tenhunen O, Sármán B, Kerkelä R, Szokodi I, Papp L, Tóth M, Ruskoaho H
J Biol Chem. 2004
PubMed ID: 15051723
Ablation of the CLP-1 gene leads to down-regulation of the HAND1 gene and abnormality of the left ventricle of the heart and fetal death.
Huang F, Wagner M, Siddiqui MA
Mech Dev. 2004
PubMed ID: 15172687
Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality.
Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, Concordet JP, Paulin D, Li Z, Daegelen D
Mol Cell Biol. 2004
PubMed ID: 15169892
Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.
Lincoln J, Alfieri CM, Yutzey KE
Dev Dyn. 2004
PubMed ID: 15162503
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expre
Su K, Li X, Edberg JC, Wu J, Ferguson P, Kimberly RP
J Immunol. 2004
PubMed ID: 15153544
Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity.
Aries A, Paradis P, Lefebvre C, Schwartz RJ, Nemer M
Proc Natl Acad Sci U S A. 2004
PubMed ID: 15100413
GATA-4 and GATA-6 modulate tissue-specific transcription of the human gene for P450c17 by direct interaction with Sp1.
Flück CE, Miller WL
Mol Endocrinol. 2004
PubMed ID: 14988427
Differential expression and function of Tbx5 and Tbx20 in cardiac development.
Plageman TF, Yutzey KE
J Biol Chem. 2004
PubMed ID: 14978031
High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.
Kwitek AE, Gullings-Handley J, Yu J, Carlos DC, Orlebeke K, Nie J, Eckert J, Lemke A, Andrae JW, Bromberg S, Pasko D, Chen D, Scheetz TE, Casavant TL, Soares MB, Sheffield VC, Tonellato PJ, Jacob HJ
Genome Res. 2004
PubMed ID: 15060019
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Worley KC, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, Birney E, Mongin E, Ureta-Vidal A, Woodwark C, Zdobnov E, Bork P, Suyama M, Torrents D, Alexandersson M, Trask BJ, Young JM, Huang H, Wang H, Xing H, Daniels S, Gietzen D, Schmidt J, Stevens K, Vitt U, Wingrove J, Camara F, Mar Albà M, Abril JF, Guigo R, Smit A, Dubchak I, Rubin EM, Couronne O, Poliakov A, Hübner N, Ganten D, Goesele C, Hummel O, Kreitler T, Lee YA, Monti J, Schulz H, Zimdahl H, Himmelbauer H, Lehrach H, Jacob HJ, Bromberg S, Gullings-Handley J, Jensen-Seaman MI, Kwitek AE, Lazar J, Pasko D, Tonellato PJ, Twigger S, Ponting CP, Duarte JM, Rice S, Goodstadt L, Beatson SA, Emes RD, Winter EE, Webber C, Brandt P, Nyakatura G, Adetobi M, Chiaromonte F, Elnitski L, Eswara P, Hardison RC, Hou M, Kolbe D, Makova K, Miller W, Nekrutenko A, Riemer C, Schwartz S, Taylor J, Yang S, Zhang Y, Lindpaintner K, Andrews TD, Caccamo M, Clamp M, Clarke L, Curwen V, Durbin R, Eyras E, Searle SM, Cooper GM, Batzoglou S, Brudno M, Sidow A, Stone EA, Venter JC, Payseur BA, Bourque G, López-Otín C, Puente XS, Chakrabarti K, Chatterji S, Dewey C, Pachter L, Bray N, Yap VB, Caspi A, Tesler G, Pevzner PA, Haussler D, Roskin KM, Baertsch R, Clawson H, Furey TS, Hinrichs AS, Karolchik D, Kent WJ, Rosenbloom KR, Trumbower H, Weirauch M, Cooper DN, Stenson PD, Ma B, Brent M, Arumugam M, Shteynberg D, Copley RR, Taylor MS, Riethman H, Mudunuri U, Peterson J, Guyer M, Felsenfeld A, Old S, Mockrin S, Collins F, Rat Genome Sequencing Project Consortium
Nature. 2004
PubMed ID: 15057822
Maspin plays an essential role in early embryonic development.
Gao F, Shi HY, Daughty C, Cella N, Zhang M
Development. 2004
PubMed ID: 14985257
Differential requirement for steroidogenic factor-1 gene dosage in adrenal development versus endocrine function.
Bland ML, Fowkes RC, Ingraham HA
Mol Endocrinol. 2004
PubMed ID: 14726490
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer.
Brown CO, Chi X, Garcia-Gras E, Shirai M, Feng XH, Schwartz RJ
J Biol Chem. 2004
PubMed ID: 14662776
Regulation of human microsomal epoxide hydrolase gene (EPHX1) expression by the transcription factor GATA-4.
Zhu QS, Qian B, Levy D
Biochim Biophys Acta. 2004
PubMed ID: 14984931
Development gone awry: congenital heart disease.
Gruber PJ, Epstein JA
Circ Res. 2004
PubMed ID: 14976138
In vivo and in vitro constant expression of GATA-4 in mouse postnatal Sertoli cells.
Imai T, Kawai Y, Tadokoro Y, Yamamoto M, Nishimune Y, Yomogida K
Mol Cell Endocrinol. 2004
PubMed ID: 15062549
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.
Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS
Development. 2004
PubMed ID: 14736744
Hepatic erythropoietin gene regulation by GATA-4.
Dame C, Sola MC, Lim KC, Leach KM, Fandrey J, Ma Y, Knöpfle G, Engel JD, Bungert J
J Biol Chem. 2004
PubMed ID: 14583613
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S
Nat Genet. 2004
PubMed ID: 14702039
Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.
Martin CM, Meeson AP, Robertson SM, Hawke TJ, Richardson JA, Bates S, Goetsch SC, Gallardo TD, Garry DJ
Dev Biol. 2004
PubMed ID: 14697368
Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains.
Rodriguez M, Yu X, Chen J, Songyang Z
J Biol Chem. 2003
PubMed ID: 14578343
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer.
Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB
Mol Cell Biol. 2003
PubMed ID: 14612389
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development.
Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14614148
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Zambrowicz BP, Abuin A, Ramirez-Solis R, Richter LJ, Piggott J, BeltrandelRio H, Buxton EC, Edwards J, Finch RA, Friddle CJ, Gupta A, Hansen G, Hu Y, Huang W, Jaing C, Key BW, Kipp P, Kohlhauff B, Ma ZQ, Markesich D, Payne R, Potter DG, Qian N, Shaw J, Schrick J, Shi ZZ, Sparks MJ, Van Sligtenhorst I, Vogel P, Walke W, Xu N, Zhu Q, Person C, Sands AT
Proc Natl Acad Sci U S A. 2003
PubMed ID: 14610273
Early stage-specific inhibitions of cardiomyocyte differentiation and expression of Csx/Nkx-2.5 and GATA-4 by phosphatidylinositol 3-kinase inhibitor LY294002.
Naito AT, Tominaga A, Oyamada M, Oyamada Y, Shiraishi I, Monzen K, Komuro I, Takamatsu T
Exp Cell Res. 2003
PubMed ID: 14597408
A mutated form of steroidogenic factor 1 (SF-1 G35E) that causes sex reversal in humans fails to synergize with transcription factor GATA-4.
Tremblay JJ, Viger RS
J Biol Chem. 2003
PubMed ID: 12907682
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.
Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D, McDonald LP, Niederreither K, Dolle P, Bruneau BG, Zorn AM, Harvey RP
Dev Biol. 2003
PubMed ID: 14550786
Dynamics of ovarian development in the FORKO immature mouse: structural and functional implications for ovarian reserve.
Balla A, Danilovich N, Yang Y, Sairam MR
Biol Reprod. 2003
PubMed ID: 12801993
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Umans L, Vermeire L, Francis A, Chang H, Huylebroeck D, Zwijsen A
Genesis. 2003
PubMed ID: 14502571
Mouse strain susceptibility to gonadectomy-induced adrenocortical tumor formation correlates with the expression of GATA-4 and luteinizing hormone receptor.
Bielinska M, Parviainen H, Porter-Tinge SB, Kiiveri S, Genova E, Rahman N, Huhtaniemi IT, Muglia LJ, Heikinheimo M, Wilson DB
Endocrinology. 2003
PubMed ID: 12933687
The different cardiac expression of the type 2 iodothyronine deiodinase gene between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors.
Dentice M, Morisco C, Vitale M, Rossi G, Fenzi G, Salvatore D
Mol Endocrinol. 2003
PubMed ID: 12775767
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.
Garg V, Kathiriya IS, Barnes R, Schluterman MK, King IN, Butler CA, Rothrock CR, Eapen RS, Hirayama-Yamada K, Joo K, Matsuoka R, Cohen JC, Srivastava D
Nature. 2003
PubMed ID: 12845333
GATA-4 is a nuclear mediator of mechanical stretch-activated hypertrophic program.
Pikkarainen S, Tokola H, Majalahti-Palviainen T, Kerkela R, Hautala N, Bhalla SS, Charron F, Nemer M, Vuolteenaho O, Ruskoaho H
J Biol Chem. 2003
PubMed ID: 12704188
Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells.
Tremblay JJ, Viger RS
J Biol Chem. 2003
PubMed ID: 12670947
Intracellular calcium plays an essential role in cardiac development.
Porter GA, Makuck RF, Rivkees SA
Dev Dyn. 2003
PubMed ID: 12761855
High-level activation by a duodenum-specific enhancer requires functional GATA binding sites.
Dusing MR, Florence EA, Wiginton DA
Am J Physiol Gastrointest Liver Physiol. 2003
PubMed ID: 12571085
Na+/Ca2+ exchanger-deficient mice have disorganized myofibrils and swollen mitochondria in cardiomyocytes.
Wakimoto K, Fujimura H, Iwamoto T, Oka T, Kobayashi K, Kita S, Kudoh S, Kuro-o M, Nabeshima Y, Shigekawa M, Imai Y, Komuro I
Comp Biochem Physiol B Biochem Mol Biol. 2003
PubMed ID: 12781968
Angiomotin regulates visceral endoderm movements during mouse embryogenesis.
Shimono A, Behringer RR
Curr Biol. 2003
PubMed ID: 12676095
FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression.
Anttonen M, Ketola I, Parviainen H, Pusa AK, Heikinheimo M
Biol Reprod. 2003
PubMed ID: 12606418
Dax1 regulates testis cord organization during gonadal differentiation.
Meeks JJ, Crawford SE, Russell TA, Morohashi K, Weiss J, Jameson JL
Development. 2003
PubMed ID: 12538527
Retinoid X receptor alpha represses GATA-4-mediated transcription via a retinoid-dependent interaction with the cardiac-enriched repressor FOG-2.
Clabby ML, Robison TA, Quigley HF, Wilson DB, Kelly DP
J Biol Chem. 2003
PubMed ID: 12480945
Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.
Nemer G, Nemer M
Dev Biol. 2003
PubMed ID: 12606287
Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.
Ishikawa TO, Tamai Y, Li Q, Oshima M, Taketo MM
Dev Biol. 2003
PubMed ID: 12645927
Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.
Chang DF, Belaguli NS, Iyer D, Roberts WB, Wu SP, Dong XR, Marx JG, Moore MS, Beckerle MC, Majesky MW, Schwartz RJ
Dev Cell. 2003
PubMed ID: 12530967
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Mammalian Gene Collection Program Team
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12477932
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y, FANTOM Consortium, RIKEN Genome Exploration Research Group Phase I & II Team
Nature. 2002
PubMed ID: 12466851
A differential screen for putative targets of the bHLH transcription factor Hand1 in cardiac morphogenesis.
Smart N, Hill AA, Cross JC, Riley PR
Mech Dev. 2002
PubMed ID: 14516662
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis.
Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G
Mech Dev. 2002
PubMed ID: 12464436
Transcription factors GATA-4 and GATA-6 during mouse and human adrenocortical development.
Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M
Endocr Res. 2002
PubMed ID: 12530677
Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis.
Yang DH, Smith ER, Roland IH, Sheng Z, He J, Martin WD, Hamilton TC, Lambeth JD, Xu XX
Dev Biol. 2002
PubMed ID: 12413896
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
Tevosian SG, Albrecht KH, Crispino JD, Fujiwara Y, Eicher EM, Orkin SH
Development. 2002
PubMed ID: 12223418
Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.
Ketola I, Anttonen M, Vaskivuo T, Tapanainen JS, Toppari J, Heikinheimo M
Eur J Endocrinol. 2002
PubMed ID: 12213678
Cooperative interaction between GATA5 and NF-ATc regulates endothelial-endocardial differentiation of cardiogenic cells.
Nemer G, Nemer M
Development. 2002
PubMed ID: 12163407
Hepatocyte nuclear factor-1 alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene.
Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG
J Biol Chem. 2002
PubMed ID: 12060663
The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation.
Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC
Proc Natl Acad Sci U S A. 2002
PubMed ID: 12149478
Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.
Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo MM, Kemler R
Dev Cell. 2002
PubMed ID: 12194849
Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue.
Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M
Endocrinology. 2002
PubMed ID: 12130579
The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism.
Dai YS, Cserjesi P, Markham BE, Molkentin JD
J Biol Chem. 2002
PubMed ID: 11994297
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.
Mural RJ, Adams MD, Myers EW, Smith HO, Miklos GL, Wides R, Halpern A, Li PW, Sutton GG, Nadeau J, Salzberg SL, Holt RA, Kodira CD, Lu F, Chen L, Deng Z, Evangelista CC, Gan W, Heiman TJ, Li J, Li Z, Merkulov GV, Milshina NV, Naik AK, Qi R, Shue BC, Wang A, Wang J, Wang X, Yan X, Ye J, Yooseph S, Zhao Q, Zheng L, Zhu SC, Biddick K, Bolanos R, Delcher AL, Dew IM, Fasulo D, Flanigan MJ, Huson DH, Kravitz SA, Miller JR, Mobarry CM, Reinert K, Remington KA, Zhang Q, Zheng XH, Nusskern DR, Lai Z, Lei Y, Zhong W, Yao A, Guan P, Ji RR, Gu Z, Wang ZY, Zhong F, Xiao C, Chiang CC, Yandell M, Wortman JR, Amanatides PG, Hladun SL, Pratts EC, Johnson JE, Dodson KL, Woodford KJ, Evans CA, Gropman B, Rusch DB, Venter E, Wang M, Smith TJ, Houck JT, Tompkins DE, Haynes C, Jacob D, Chin SH, Allen DR, Dahlke CE, Sanders R, Li K, Liu X, Levitsky AA, Majoros WH, Chen Q, Xia AC, Lopez JR, Donnelly MT, Newman MH, Glodek A, Kraft CL, Nodell M, Ali F, An HJ, Baldwin-Pitts D, Beeson KY, Cai S, Carnes M, Carver A, Caulk PM, Center A, Chen YH, Cheng ML, Coyne MD, Crowder M, Danaher S, Davenport LB, Desilets R, Dietz SM, Doup L, Dullaghan P, Ferriera S, Fosler CR, Gire HC, Gluecksmann A, Gocayne JD, Gray J, Hart B, Haynes J, Hoover J, Howland T, Ibegwam C, Jalali M, Johns D, Kline L, Ma DS, MacCawley S, Magoon A, Mann F, May D, McIntosh TC, Mehta S, Moy L, Moy MC, Murphy BJ, Murphy SD, Nelson KA, Nuri Z, Parker KA, Prudhomme AC, Puri VN, Qureshi H, Raley JC, Reardon MS, Regier MA, Rogers YH, Romblad DL, Schutz J, Scott JL, Scott R, Sitter CD, Smallwood M, Sprague AC, Stewart E, Strong RV, Suh E, Sylvester K, Thomas R, Tint NN, Tsonis C, Wang G, Wang G, Williams MS, Williams SM, Windsor SM, Wolfe K, Wu MM, Zaveri J, Chaturvedi K, Gabrielian AE, Ke Z, Sun J, Subramanian G, Venter JC, Pfannkoch CM, Barnstead M, Stephenson LD
Science. 2002
PubMed ID: 12040188
Depletion of definitive gut endoderm in Sox17-null mutant mice.
Kanai-Azuma M, Kanai Y, Gad JM, Tajima Y, Taya C, Kurohmaru M, Sanai Y, Yonekawa H, Yazaki K, Tam PP, Hayashi Y
Development. 2002
PubMed ID: 11973269
Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.
Kerkelä R, Pikkarainen S, Majalahti-Palviainen T, Tokola H, Ruskoaho H
J Biol Chem. 2002
PubMed ID: 11827958
Differentiation of embryonic stem cells is induced by GATA factors.
Fujikura J, Yamato E, Yonemura S, Hosoda K, Masui S, Nakao K, Miyazaki Ji J, Niwa H
Genes Dev. 2002
PubMed ID: 11937486
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
Wei L, Imanaka-Yoshida K, Wang L, Zhan S, Schneider MD, DeMayo FJ, Schwartz RJ
Development. 2002
PubMed ID: 11923206
Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy.
Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S
J Biol Chem. 2002
PubMed ID: 11739382
Mouse Pop1 is required for muscle regeneration in adult skeletal muscle.
Andrée B, Fleige A, Arnold HH, Brand T
Mol Cell Biol. 2002
PubMed ID: 11839816
Roles of protein kinase C and alpha-tocopherol in regulation of signal transduction for GATA-4 phosphorylation in HL-1 cardiac muscle cells.
Clément SA, Tan CC, Guo J, Kitta K, Suzuki YJ
Free Radic Biol Med. 2002
PubMed ID: 11841924
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4.
Cirillo LA, Lin FR, Cuesta I, Friedman D, Jarnik M, Zaret KS
Mol Cell. 2002
PubMed ID: 11864602
Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.
Crawford SE, Qi C, Misra P, Stellmach V, Rao MS, Engel JD, Zhu Y, Reddy JK
J Biol Chem. 2002
PubMed ID: 11724781
Direct left ventricular wall stretch activates GATA4 binding in perfused rat heart: involvement of autocrine/paracrine pathways.
Hautala N, Tenhunen O, Szokodi I, Ruskoaho H
Pflugers Arch. 2002
PubMed ID: 11810204
Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium.
Jacobsen CM, Narita N, Bielinska M, Syder AJ, Gordon JI, Wilson DB
Dev Biol. 2002
PubMed ID: 11784093
The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes.
Liang Q, Wiese RJ, Bueno OF, Dai YS, Markham BE, Molkentin JD
Mol Cell Biol. 2001
PubMed ID: 11585926
p300 Functions as a coactivator of transcription factor GATA-4.
Dai YS, Markham BE
J Biol Chem. 2001
PubMed ID: 11481322
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.
Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG
Cell. 2001
PubMed ID: 11572777
The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo.
Liang Q, De Windt LJ, Witt SA, Kimball TR, Markham BE, Molkentin JD
J Biol Chem. 2001
PubMed ID: 11356841
Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.
Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D
Nature. 2001
PubMed ID: 11298452
Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors.
Crispino JD, Lodish MB, Thurberg BL, Litovsky SH, Collins T, Molkentin JD, Orkin SH
Genes Dev. 2001
PubMed ID: 11297508
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse.
Niederreither K, Vermot J, Messaddeq N, Schuhbaur B, Chambon P, Dollé P
Development. 2001
PubMed ID: 11245568
BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development.
Dauvillier S, Ott MO, Renard JP, Legouy E
Mech Dev. 2001
PubMed ID: 11231080
Functional annotation of a full-length mouse cDNA collection.
Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y, RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature. 2001
PubMed ID: 11217851
Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.
Morin S, Paradis P, Aries A, Nemer M
Mol Cell Biol. 2001
PubMed ID: 11158291
Functional analyses of three Csx/Nkx-2.5 mutations that cause human congenital heart disease.
Zhu W, Shiojima I, Hiroi Y, Zou Y, Akazawa H, Mizukami M, Toko H, Yazaki Y, Nagai R, Komuro I
J Biol Chem. 2000
PubMed ID: 10948187
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Shibata K, Itoh M, Aizawa K, Nagaoka S, Sasaki N, Carninci P, Konno H, Akiyama J, Nishi K, Kitsunai T, Tashiro H, Itoh M, Sumi N, Ishii Y, Nakamura S, Hazama M, Nishine T, Harada A, Yamamoto R, Matsumoto H, Sakaguchi S, Ikegami T, Kashiwagi K, Fujiwake S, Inoue K, Togawa Y
Genome Res. 2000
PubMed ID: 11076861
Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.
Raymond CS, Murphy MW, O'Sullivan MG, Bardwell VJ, Zarkower D
Genes Dev. 2000
PubMed ID: 11040213
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Carninci P, Shibata Y, Hayatsu N, Sugahara Y, Shibata K, Itoh M, Konno H, Okazaki Y, Muramatsu M, Hayashizaki Y
Genome Res. 2000
PubMed ID: 11042159
Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators.
Belaguli NS, Sepulveda JL, Nigam V, Charron F, Nemer M, Schwartz RJ
Mol Cell Biol. 2000
PubMed ID: 11003651
Staging of the commitment of murine cardiac cell progenitors.
Auda-Boucher G, Bernard B, Fontaine-Pérus J, Rouaud T, Mericksay M, Gardahaut MF
Dev Biol. 2000
PubMed ID: 10964476
Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.
Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP
Dev Biol. 2000
PubMed ID: 10926756
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray.
Tanaka TS, Jaradat SA, Lim MK, Kargul GJ, Wang X, Grahovac MJ, Pantano S, Sano Y, Piao Y, Nagaraja R, Doi H, Wood WH, Becker KG, Ko MS
Proc Natl Acad Sci U S A. 2000
PubMed ID: 10922068
A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2.
Svensson EC, Huggins GS, Lin H, Clendenin C, Jiang F, Tufts R, Dardik FB, Leiden JM
Nat Genet. 2000
PubMed ID: 10888889
FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium.
Tevosian SG, Deconinck AE, Tanaka M, Schinke M, Litovsky SH, Izumo S, Fujiwara Y, Orkin SH
Cell. 2000
PubMed ID: 10892744
GATA-dependent recruitment of MEF2 proteins to target promoters.
Morin S, Charron F, Robitaille L, Nemer M
EMBO J. 2000
PubMed ID: 10790371
BMP type II receptor is required for gastrulation and early development of mouse embryos.
Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, Miyazono K
Dev Biol. 2000
PubMed ID: 10772805
A minimal critical region of the 8p22-23 amplicon in esophageal adenocarcinomas defined using sequence tagged site-amplification mapping and quantitative polymerase chain reaction includes the GATA-4 gene.
Lin L, Aggarwal S, Glover TW, Orringer MB, Hanash S, Beer DG
Cancer Res. 2000
PubMed ID: 10728696
Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation.
Coffinier C, Thépot D, Babinet C, Yaniv M, Barra J
Development. 1999
PubMed ID: 10518495
Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a direct interaction with the nuclear receptor SF-1.
Tremblay JJ, Viger RS
Mol Endocrinol. 1999
PubMed ID: 10446911
MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube.
Saga Y, Miyagawa-Tomita S, Takagi A, Kitajima S, Miyazaki J, Inoue T
Development. 1999
PubMed ID: 10393122
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis.
Komada M, Soriano P
Genes Dev. 1999
PubMed ID: 10364163
A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart.
Xavier-Neto J, Neville CM, Shapiro MD, Houghton L, Wang GF, Nikovits W, Stockdale FE, Rosenthal N
Development. 1999
PubMed ID: 10331979
Cooperative interaction between GATA-4 and GATA-6 regulates myocardial gene expression.
Charron F, Paradis P, Bronchain O, Nemer G, Nemer M
Mol Cell Biol. 1999
PubMed ID: 10330176
Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects.
Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk MM, Zwijsen A
Development. 1999
PubMed ID: 10079226
Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis.
Ketola I, Rahman N, Toppari J, Bielinska M, Porter-Tinge SB, Tapanainen JS, Huhtaniemi IT, Wilson DB, Heikinheimo M
Endocrinology. 1999
PubMed ID: 10067876
The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development.
Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S
Development. 1999
PubMed ID: 10021345
Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes.
Svensson EC, Tufts RL, Polk CE, Leiden JM
Proc Natl Acad Sci U S A. 1999
PubMed ID: 9927675
Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes.
Xu C, Liguori G, Persico MG, Adamson ED
Development. 1999
PubMed ID: 9876177
Identification of the in vivo casein kinase II phosphorylation site within the homeodomain of the cardiac tisue-specifying homeobox gene product Csx/Nkx2.5.
Kasahara H, Izumo S
Mol Cell Biol. 1999
PubMed ID: 9858576
Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer.
Lien CL, Wu C, Mercer B, Webb R, Richardson JA, Olson EN
Development. 1999
PubMed ID: 9834187
High-efficiency full-length cDNA cloning.
Carninci P, Hayashizaki Y
Methods Enzymol. 1999
PubMed ID: 10349636
Myocyte enhancer factor 2C and Nkx2-5 up-regulate each other's expression and initiate cardiomyogenesis in P19 cells.
Skerjanc IS, Petropoulos H, Ridgeway AG, Wilton S
J Biol Chem. 1998
PubMed ID: 9857019
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.
Roebroek AJ, Umans L, Pauli IG, Robertson EJ, van Leuven F, Van de Ven WJ, Constam DB
Development. 1998
PubMed ID: 9811571
GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo.
Morrisey EE, Tang Z, Sigrist K, Lu MM, Jiang F, Ip HS, Parmacek MS
Genes Dev. 1998
PubMed ID: 9832509
Combinatorial cis-acting elements control tissue-specific activation of the cardiac troponin I gene in vitro and in vivo.
Di Lisi R, Millino C, Calabria E, Altruda F, Schiaffino S, Ausoni S
J Biol Chem. 1998
PubMed ID: 9738004
The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis.
Dufort D, Schwartz L, Harpal K, Rossant J
Development. 1998
PubMed ID: 9671576
Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.
Viger RS, Mertineit C, Trasler JM, Nemer M
Development. 1998
PubMed ID: 9636081
The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression.
Lee Y, Shioi T, Kasahara H, Jobe SM, Wiese RJ, Markham BE, Izumo S
Mol Cell Biol. 1998
PubMed ID: 9584153
Expression of GATA-4 in migrating gonadotropin-releasing neurons of the developing mouse.
Lawson MA, Mellon PL
Mol Cell Endocrinol. 1998
PubMed ID: 9722184
Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation.
Gao X, Sedgwick T, Shi YB, Evans T
Mol Cell Biol. 1998
PubMed ID: 9566909
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.
Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN
Cell. 1998
PubMed ID: 9568714
Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.
Dragatsis I, Efstratiadis A, Zeitlin S
Development. 1998
PubMed ID: 9502734
The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis.
Riley P, Anson-Cartwright L, Cross JC
Nat Genet. 1998
PubMed ID: 9500551
Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development.
Tanaka M, Kasahara H, Bartunkova S, Schinke M, Komuro I, Inagaki H, Lee Y, Lyons GE, Izumo S
Dev Genet. 1998
PubMed ID: 9621431
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.
Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, Mak TW
Genes Dev. 1998
PubMed ID: 9420335
Cardiomyocyte differentiation by GATA-4-deficient embryonic stem cells.
Narita N, Bielinska M, Wilson DB
Development. 1997
PubMed ID: 9367431
The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors.
Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M
EMBO J. 1997
PubMed ID: 9312027
Wild-type endoderm abrogates the ventral developmental defects associated with GATA-4 deficiency in the mouse.
Narita N, Bielinska M, Wilson DB
Dev Biol. 1997
PubMed ID: 9299119
Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary.
Heikinheimo M, Ermolaeva M, Bielinska M, Rahman NA, Narita N, Huhtaniemi IT, Tapanainen JS, Wilson DB
Endocrinology. 1997
PubMed ID: 9231805
Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload.
Herzig TC, Jobe SM, Aoki H, Molkentin JD, Cowley AW, Izumo S, Markham BE
Proc Natl Acad Sci U S A. 1997
PubMed ID: 9207128
Induction of yolk sac endoderm in GATA-4-deficient embryoid bodies by retinoic acid.
Bielinska M, Wilson DB
Mech Dev. 1997
PubMed ID: 9256344
Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND.
Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN
Nat Genet. 1997
PubMed ID: 9171826
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis.
Molkentin JD, Lin Q, Duncan SA, Olson EN
Genes Dev. 1997
PubMed ID: 9136933
GATA4 transcription factor is required for ventral morphogenesis and heart tube formation.
Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM
Genes Dev. 1997
PubMed ID: 9136932
The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.
Deussing J, Roth W, Rommerskirch W, Wiederanders B, von Figura K, Peters C
Mamm Genome. 1997
PubMed ID: 9096102
GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily.
Morrisey EE, Ip HS, Tang Z, Parmacek MS
J Biol Chem. 1997
PubMed ID: 9079680
GATA-5: a transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development.
Morrisey EE, Ip HS, Tang Z, Lu MM, Parmacek MS
Dev Biol. 1997
PubMed ID: 9119112
Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos.
Duncan SA, Nagy A, Chan W
Development. 1997
PubMed ID: 9053305
The gene for transcription factor GATA-6 resides on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle.
Narita N, Heikinheimo M, Bielinska M, White RA, Wilson DB
Genomics. 1996
PubMed ID: 8812463
Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus.
McGrew MJ, Bogdanova N, Hasegawa K, Hughes SH, Kitsis RN, Rosenthal N
Mol Cell Biol. 1996
PubMed ID: 8754853
GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm.
Morrisey EE, Ip HS, Lu MM, Parmacek MS
Dev Biol. 1996
PubMed ID: 8660897
Chromosomal assignment of four testis-expressed mouse genes from a new family of transmembrane proteins (ADAMs) involved in cell-cell adhesion and fusion.
Cho C, Primakoff P, White JM, Myles DG
Genomics. 1996
PubMed ID: 8786143
Assignment of the human GATA4 gene to 8p23.1-->p22 using fluorescence in situ hybridization analysis.
Huang WY, Heng HH, Liew CC
Cytogenet Cell Genet. 1996
PubMed ID: 8978781
Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro.
Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, Wilson DB
Development. 1995
PubMed ID: 8582296
Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins.
Yamagata T, Nishida J, Sakai R, Tanaka T, Honda H, Hirano N, Mano H, Yazaki Y, Hirai H
Mol Cell Biol. 1995
PubMed ID: 7791790
The mouse Gata4 transcription factor maps to chromosome 14.
Sebastiani G, Grépin C, Nemer M, Malo D
Mamm Genome. 1995
PubMed ID: 7647471
Assignment of the transcription factor GATA4 gene to human chromosome 8 and mouse chromosome 14: Gata4 is a candidate gene for Ds (disorganization).
White RA, Dowler LL, Pasztor LM, Gatson LL, Adkison LR, Angeloni SV, Wilson DB
Genomics. 1995
PubMed ID: 7665171
Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA.
Huang WY, Cukerman E, Liew CC
Gene. 1995
PubMed ID: 7721094
Regulation of J6 gene expression by transcription factor GATA-4.
Bielinska M, Wilson DB
Biochem J. 1995
PubMed ID: 7717974
GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut.
Laverriere AC, MacNeill C, Mueller C, Poelmann RE, Burch JB, Evans T
J Biol Chem. 1994
PubMed ID: 8083222
Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development.
Heikinheimo M, Scandrett JM, Wilson DB
Dev Biol. 1994
PubMed ID: 8045339
Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene.
Molkentin JD, Kalvakolanu DV, Markham BE
Mol Cell Biol. 1994
PubMed ID: 8007990
Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes.
Tamura S, Wang XH, Maeda M, Futai M
Proc Natl Acad Sci U S A. 1994
PubMed ID: 8183957
Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes.
Tamura S, Wang XH, Maeda M, Futai M
Proc Natl Acad Sci U S A. 1993
PubMed ID: 8248184
Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.
Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB
Mol Cell Biol. 1993
PubMed ID: 8455608
An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes.
Evans T, Reitman M, Felsenfeld G
Proc Natl Acad Sci U S A. 1988
PubMed ID: 3413070

Model Organism Phenotype Links from MGI Top Help

Model Organism Phenotype Links

External Links Top Help

	Human	Mouse	Rat
Entrez Gene	2626	14463	54254
EnsEMBL Gene(s)	ENSG00000136574	ENSMUSG00000021944	ENSRNOG00000010708
Unigene	Hs.243987	Mm.247669	Rn.26251
Homologene	GATA4	Gata4	Gata4
OMIM	600576	N/A	N/A
GeneCards	GATA4	N/A	N/A
Beta Cell Genomics	DT.306804 DT.452800 DT.97840387	DT.110768372 DT.530169	N/A
Reactome	N/A	N/A	N/A
Plasma Peptide Atlas	N/A	N/A	N/A
WikiGenes	2626	14463	54254

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Interactor	Interactor	Sources	Classification	Pubmed IDs
GATA4	CDK9	BioGRID	empirical	20081228
GATA4	CRIP2	HPRD	empirical	12530967
GATA4	NKX2-5	HPRD, IntAct, MIPS, BioGRID	empirical	9312027 10948187 12845333 9584153
GATA4	ZFPM1	Reactome	predicted	9927674 9230307
GATA4	EP300	HPRD, MINT, BioGRID	empirical	11481322 18252717 20081228
GATA4	EZH1	BioGRID	empirical	22215809
GATA4	ZFPM2	HPRD, BioGRID, Reactome	empirical	9927675 11297508 18252717 9927674 9230307
GATA4	SUZ12	BioGRID	empirical	22215809
GATA4	FOS	HPRD	empirical	9207128
GATA4	NR5A1	HPRD	empirical	10446911
GATA4	HDAC2	BioGRID	empirical	20833366
GATA4	ID1	BioGRID	empirical	16556596
GATA4	ID2	BioGRID	empirical	16556596
GATA4	ID3	BioGRID	empirical	16556596
GATA4	JARID2	HPRD, IntAct, BioGRID	empirical	15542826 22215809
GATA4	SMAD1	BioGRID	empirical	14662776
GATA4	SMAD2	BioGRID	empirical	14662776
GATA4	SMAD3	BioGRID	empirical	14662776
GATA4	SMAD4	BioGRID	empirical	14662776
GATA4	MEF2C	HPRD	empirical	10790371
GATA4	NFATC4	HPRD	empirical	9568714
GATA4	KLF13	MINT	empirical	17053787
GATA4	PPARA	BioGRID	empirical	11724781
GATA4	MED1	HPRD, BioGRID	empirical	11724781 20211142
GATA4	MAPK1	BioGRID	empirical	11585926
GATA4	MAPK3	HPRD	empirical	11585926
GATA4	ACTB	BioGRID	empirical	20081228
GATA4	ALX4	BioGRID	empirical	20211142
GATA4	SMARCA4	BioGRID	empirical	15525990
GATA4	SMARCD3	BioGRID	empirical	15525990
GATA4	SP1	BioGRID	empirical	14988427 21184844
GATA4	SRF	HPRD, BioGRID	empirical	11003651 11158291 12530967
GATA4	TBX5	HPRD, IntAct, BioGRID	empirical	12845333
GATA4	ZBTB3	BioGRID	empirical	20211142
GATA4	PIAS1	HPRD	empirical	15337742
GATA4	CCNT1	BioGRID	empirical	20081228
GATA4	HAND2	HPRD, BioGRID	empirical	11994297
GATA4	MDC1	BioGRID	empirical	14578343